{"id":98694,"date":"2023-11-22T11:34:00","date_gmt":"2023-11-22T04:34:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023112211340098694"},"modified":"2023-11-22T22:22:54","modified_gmt":"2023-11-22T14:22:54","slug":"diabetes-care%e5%8f%91%e8%a1%a8%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e7%8e%9b%e4%bb%95%e5%ba%a6%e8%82%bd-ibi362-%e5%9c%a8%e4%b8%ad%e5%9b%bd2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e5%8f%97%e8%af%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023112211340098694","title":{"rendered":"Diabetes Care\u53d1\u8868\u4fe1\u8fbe\u751f\u7269\u739b\u4ed5\u5ea6\u80bd (IBI362) \u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u5168\u6587"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e7411\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u91cd\u6fc0\u52a8\u5242\u739b\u4ed5\u5ea6\u80bd\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI362\uff09\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u5168\u6587\u8fd1\u65e5\u5728\u56fd\u9645\u6743\u5a01\u7cd6\u5c3f\u75c5\u671f\u520a<a href=\"https:\/\/diabetesjournals.org\/care\/article\/doi\/10.2337\/dc23-1287\/153858\/Efficacy-and-Safety-of-Mazdutide-in-Chinese\" rel=\"nofollow noopener\" target=\"_blank\"><em>Diabetes Care<\/em><\/a>\u5728\u7ebf\u53d1\u8868\u3002<\/p>\n<p><strong>\u672c\u6587\u901a\u8baf\u4f5c\u8005\u53ca\u672c\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u65e5\u53cb\u597d\u533b\u9662\u5185\u5206\u6ccc\u79d1\u6768\u6587\u82f1\u6559\u6388<\/strong>\u8868\u793a\uff1a&#8221;\u76ee\u524d\uff0c\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4ecd\u5b58\u5728\u8840\u7cd6\u603b\u4f53\u8fbe\u6807\u7387\u504f\u4f4e\uff0c\u4e14\u60a3\u8005\u5f80\u5f80\u5408\u5e76\u591a\u79cd\u5fc3\u8840\u7ba1\u4ee3\u8c22\u98ce\u9669\u56e0\u7d20\uff0c\u5982\u80a5\u80d6\uff0c\u9ad8\u8102\u8840\u75c7\uff0c\u51a0\u5fc3\u75c5\uff0c\u8102\u80aa\u809d\uff0c\u75db\u98ce\u7b49\u60c5\u51b5\uff0c\u8fd9\u65e2\u589e\u52a0\u4e86\u60a3\u8005\u7684\u75be\u75c5\u8d1f\u62c5\uff0c\u4e5f\u7ed9\u4e34\u5e8a\u6cbb\u7597\u589e\u52a0\u4e86\u96be\u5ea6\u548c\u590d\u6742\u6027\u3002\u4e34\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u80fd\u6709\u7597\u6548\u786e\u5207\uff0c\u5b89\u5168\u6027\u597d\uff0c\u7ed9\u836f\u4fbf\u6377\uff0c\u4f4e\u8840\u7cd6\u98ce\u9669\u4f4e\uff0c\u4e14\u80fd\u517c\u5177\u51cf\u91cd\u4f5c\u7528\u3001\u5b9e\u73b0\u5fc3\u8840\u7ba1\u4ee3\u8c22\u591a\u91cd\u83b7\u76ca\u7684\u521b\u65b0\u836f\u7269\u3002\u5728\u6b64\u9879II\u671f\u7814\u7a76\u4e2d\uff0c\u65b0\u4e00\u4ee3GLP-1R\/GCGR\u53cc\u91cd\u6fc0\u52a8\u5242\u739b\u4ed5\u5ea6\u80bd\u4e0d\u4ec5\u5c55\u73b0\u51fa\u660e\u786e\u7684\u964d\u7cd6\u7597\u6548\uff0c\u4e14\u5728\u540c\u65f6\u964d\u4f4eHbA1c\u4e0e\u4f53\u91cd\u53cc\u9879\u6307\u6807\u4e0a\u5c55\u793a\u51fa\u4f18\u4e8eGLP-1\u5355\u9776\u836f\u7269\u5ea6\u62c9\u7cd6\u80bd\u7684\u6f5c\u8d28\uff0c\u6709\u671b\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u5408\u5e76\u80a5\u80d6\u60a3\u8005\u5e26\u6765\u989d\u5916\u83b7\u76ca\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u8fd8\u8868\u660e\uff0c\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u53d7\u8bd5\u8005\u63a5\u53d7\u739b\u4ed5\u5ea6\u80bd\u6cbb\u759720\u5468\u540e\u591a\u79cd\u5fc3\u8840\u7ba1\u4ee3\u8c22\u6307\u6807\u83b7\u76ca\u660e\u663e\uff0c\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002\u5f88\u9ad8\u5174\u770b\u5230\u7814\u7a76\u7ed3\u679c\u987a\u5229\u53d1\u8868\u4e8e<em>Diabetes Care<\/em>\uff0c\u6211\u671f\u5f85\u5728\u6b63\u5728\u8fdb\u884c\u7684\u4e24\u9879III\u671f\u7814\u7a76\u4e2d\u739b\u4ed5\u5ea6\u80bd\u53ef\u4ee5\u5c55\u73b0\u51fa\u66f4\u52a0\u60ca\u8273\u7684\u7ed3\u679c\uff0c\u5e76\u65e9\u65e5\u4e3a\u6211\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5e26\u6765\u66f4\u4f18\u7684\u6cbb\u7597\u9009\u62e9\u3002&#8221;<\/p>\n<p><strong>\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u4e34\u5e8a\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb<\/strong>\u8868\u793a\uff1a&#8221;\u739b\u4ed5\u5ea6\u80bd\u662f\u5168\u7403\u5f00\u53d1\u8fdb\u5ea6\u6700\u5feb\u7684GLP-1R\/GCGR\u53cc\u91cd\u6fc0\u52a8\u5242\uff0c\u517c\u5177\u663e\u8457\u964d\u7cd6\u51cf\u91cd\u7597\u6548\u548c\u826f\u597d\u5b89\u5168\u6027\u3002\u5728\u672c\u9879II\u671f\u7814\u7a76\u4e2d\uff0c\u739b\u4ed5\u5ea6\u80bd\u7684\u964d\u7cd6\u3001\u51cf\u91cd\u548c\u5fc3\u8840\u7ba1\u4ee3\u8c22\u7efc\u5408\u83b7\u76ca\u65b9\u9762\u7684\u4f18\u52bf\u5f97\u5230\u5168\u9762\u9a8c\u8bc1\uff0c\u5e76\u518d\u6b21\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u540c\u65f6\u76f8\u8f83\u5ea6\u62c9\u7cd6\u80bd\u7ec4\uff0c\u739b\u4ed5\u5ea6\u80bd4.5 mg\u7ec4\u548c6 mg\u7ec4\u5728\u7b2c20\u5468\u65f6\u7684HbA1c\u6c34\u5e73\u4ecd\u4fdd\u6301\u4e0b\u964d\u8d8b\u52bf\u3002\u6b64\u9879\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u7cd6\u5c3f\u75c5\u9886\u57df\u6743\u5a01\u533b\u5b66\u671f\u520a\u4e0a\uff0c\u4e00\u65b9\u9762\u8bc1\u660e\u4e86\u739b\u4ed5\u5ea6\u80bd\u4f18\u5f02\u7684\u4e34\u5e8a\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u53e6\u4e00\u65b9\u9762\u4e5f\u4f53\u73b0\u4e86\u4e2d\u56fd\u7814\u7a76\u8005\u5353\u8d8a\u7684\u4e34\u5e8a\u7814\u7a76\u6c34\u5e73\u548c\u4fe1\u8fbe\u751f\u7269\u624e\u5b9e\u7684\u7814\u53d1\u80fd\u529b<strong>\u3002<\/strong>\u76ee\u524d\uff0c\u739b\u4ed5\u5ea6\u80bd\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684\u4e24\u9879III\u671f\u6ce8\u518c\u7814\u7a76\uff08DREAMS-1\u548cDREAMS-2\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5c06\u63d0\u4f9b\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u4eba\u7fa4\u4e2d\u7684\u5927\u89c4\u6a21\u6837\u672c\u91cf\u7684\u533b\u5b66\u8bc1\u636e\uff0c\u6211\u4eec\u5e0c\u671b\u8fd9\u6b3e\u9ad8\u8d28\u91cf\u836f\u7269\u65e9\u65e5\u60e0\u53ca\u4e2d\u56fd\u5e7f\u5927\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002&#8221;<\/p>\n<p>\u672c\u6b21\u6587\u7ae0\u53d1\u5e03\u7684\u7814\u7a76\u7ed3\u679c\u6765\u81ea\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04965506\uff09\u3002\u7814\u7a76\u5171\u5165\u7ec4252\u4f8b\u5728\u7ecf\u81f3\u5c113\u4e2a\u6708\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u4f34\u6216\u4e0d\u4f34\u7a33\u5b9a\u5242\u91cf\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u540e\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73 [\u7b5b\u9009\u65f6\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c 7.0-10.5%\uff09] \u7684\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\uff0c\u63091:1:1:1:1\u968f\u673a\u63a5\u53d7\u739b\u4ed5\u5ea6\u80bd 3 mg\u30014.5 mg\u62166 mg\u3001\u5b89\u6170\u5242\u6216\u5ea6\u62c9\u7cd6\u80bd1.5 mg\uff0c\u6bcf\u5468\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f20\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u7b2c20\u5468\u65f6HbA1c\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u3002\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u6b21\u7814\u7a76\u836f\u7269\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\uff08n=250\uff09\u57fa\u7ebf\u5e73\u5747BMI\u4e3a27.4 kg\/m<sup>2<\/sup>\uff0c\u57fa\u7ebf\u5e73\u5747HbA1c \u4e3a8.06%\u3002<\/p>\n<p><strong>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5404\u5242\u91cf\u739b\u4ed5\u5ea6\u80bd\u5747\u53ef\u663e\u8457\u964d\u4f4e<\/strong><strong>HbA1c\u6c34\u5e73\u3002<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u7b2c20\u5468\u65f6\uff0c\u739b\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7ec4HbA1c\u6c34\u5e73\u8f83\u57fa\u7ebf\u53d8\u5316\u7684\u5747\u503c\u5206\u522b\u4e3a-1.41%\u3001-1.67%\u548c-1.55%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u4e3a-1.35%\uff1b\u5b89\u6170\u5242\u7ec4\u4e3a0.03%\u3002\u739b\u4ed5\u5ea6\u80bd\u5404\u5242\u91cf\u7ec4\u7b2c20\u5468\u7684HbA1c\u6c34\u5e73\u5e73\u5747\u964d\u5e45\u5747\u663e\u8457\u5927\u4e8e\u5b89\u6170\u5242\u7ec4\uff08P&lt;0.0001\uff09\u3002<\/li>\n<li>\u540c\u65f6\uff0c\u739b\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7ec4HbA1c\uff1c7.0%\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u5206\u522b\u8fbe54.0%\u300166.7%\u548c73.5%\uff08\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u4e3a60.0%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a17.6%\uff09\uff1bHbA1c&le;6.5%\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u5206\u522b\u8fbe28.0%\u300156.3%\u548c51.0%\uff08\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u4e3a46.0%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a7.8%\uff09\u3002<\/li>\n<li>\u6b64\u5916\uff0c\u5404\u5242\u91cf\u739b\u4ed5\u5ea6\u80bd\u8fd8\u80fd\u663e\u8457\u964d\u4f4e\u7a7a\u8179\u8840\u7cd6\u548c\u9910\u540e2\u5c0f\u65f6\u8840\u7cd6\u6c34\u5e73\u3002<\/li>\n<\/ul>\n<p><strong>\u4f53\u91cd\u65b9\u9762\uff0c\u5404\u5242\u91cf\u739b\u4ed5\u5ea6\u80bd\u5747\u53ef\u663e\u8457\u964d\u4f4e\u4f53\u91cd\uff0c\u51cf\u91cd\u964d\u7cd6\u53cc\u8fbe\u6807\u7387\u9ad8\u3002<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u7b2c20\u5468\u65f6\uff0c\u739b\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7ec4\u4f53\u91cd\u8f83\u57fa\u7ebf\u767e\u5206\u6bd4\u53d8\u5316\u7684\u5747\u503c\u5206\u522b\u4e3a-4.12%\u3001-5.31%\u548c-7.11%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u4e3a-2.69 %\uff1b\u5b89\u6170\u5242\u7ec4\u4e3a-1.38%\u3002<\/li>\n<li>\u540c\u65f6\uff0c\u739b\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7ec4\u4f53\u91cd\u8f83\u57fa\u7ebf\u964d\u5e45&ge;5.0%\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u5206\u522b\u8fbe24.0%\u300137.5%\u548c57.1%\uff1b\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u4e3a18.0%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a9.8%\u3002<\/li>\n<li>\u6b64\u5916\uff0c\u739b\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7ec4\u5206\u522b\u670916.0%\u300129.2%\u548c49.0%\u7684\u53d7\u8bd5\u8005\u7b2c20\u5468\u65f6\u4f53\u91cd\u8f83\u57fa\u7ebf\u964d\u5e45&ge;5.0%\u4e14HbA1c\uff1c7.0%\uff0c\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u4e3a12.0%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a0\u3002<\/li>\n<\/ul>\n<p><strong>\u739b\u4ed5\u5ea6\u80bd\u603b\u4f53\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u7814\u7a76\u6cbb\u7597\u671f\u95f4\uff0c\u739b\u4ed5\u5ea6\u80bd\u7ec4\u65e0\u53d7\u8bd5\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u63d0\u524d\u7ec8\u6b62\u7814\u7a76\u836f\u7269\u6cbb\u7597\uff0c\u65e0\u53d7\u8bd5\u8005\u53d1\u751f\u7814\u7a76\u8005\u5224\u5b9a\u4e0e\u739b\u4ed5\u5ea6\u80bd\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u7814\u7a76\u671f\u95f4\u672a\u53d1\u751f\u91cd\u5ea6\u4f4e\u8840\u7cd6\u4e8b\u4ef6\u3002<\/li>\n<li>\u739b\u4ed5\u5ea6\u80bd\u7ec4\u6574\u4f53\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u739b\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u7814\u7a76\u548c\u5176\u4ed6GLP-1\u7c7b\u836f\u7269\u76f8\u4f3c\u3002\u6700\u5e38\u62a5\u544a\u7684\u6cbb\u7597\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u8179\u6cfb\u3001\u98df\u6b32\u51cf\u9000\u3001\u6076\u5fc3\u548c\u5455\u5410\uff0c\u7edd\u5927\u591a\u6570\u4e3a\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u3002<\/li>\n<li>\u7b2c20\u5468\u65f6\uff0c\u739b\u4ed5\u5ea6\u80bd\u5404\u5242\u91cf\u7ec4\u5fc3\u7387\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u589e\u5e45\u4e0e\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u76f8\u5f53\uff0c\u672a\u89c2\u5bdf\u5230\u5fc3\u8840\u7ba1\u98ce\u9669\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/li>\n<\/ul>\n<p>\u540c\u65f6\uff0c\u739b\u4ed5\u5ea6\u80bd\u8fd8\u964d\u4f4e\u8170\u56f4\u3001\u8840\u538b\u3001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\u3001\u7518\u6cb9\u4e09\u916f\u3001\u8f6c\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8c22\u6307\u6807\u3002\u8be6\u7ec6\u6570\u636e\u89c1<em><a href=\"https:\/\/diabetesjournals.org\/care\/article\/doi\/10.2337\/dc23-1287\/153858\/Efficacy-and-Safety-of-Mazdutide-in-Chinese\" rel=\"nofollow noopener\" target=\"_blank\">Diabetes Care<\/a><\/em>\u5168\u6587\u3002<\/p>\n<p><strong>\u5173\u4e8e\u7cd6\u5c3f\u75c5<\/strong><\/p>\n<p>\u6211\u56fd\u6210\u4eba\u4e2d\u7cd6\u5c3f\u75c5\u60a3\u75c5\u7387\u4e3a11.6%\u3002\u5e73\u5747\u6bcf10\u4e2a\u6210\u5e74\u4eba\u4e2d\u5c31\u67091\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c\u5176\u4e2d2\u578b\u7cd6\u5c3f\u75c5\u7ea6\u5360\u7cd6\u5c3f\u75c5\u75c5\u4eba\u603b\u6570\u768490%\uff0c\u53d1\u75c5\u4eba\u6570\u8fd8\u5728\u4e0d\u65ad\u589e\u52a0\u3002\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\u4f1a\u5bfc\u81f4\u4e0d\u53ef\u9006\u7684\u5fae\u8840\u7ba1\u548c\u5927\u8840\u7ba1\u5e76\u53d1\u75c7\u5982\u89c6\u529b\u4e0b\u964d\u3001\u5931\u660e\u3001\u80be\u529f\u80fd\u4e0d\u5168\u3001\u5916\u5468\u795e\u7ecf\u75c5\u53d8\u3001\u5fc3\u808c\u6897\u6b7b\u3001\u4e2d\u98ce\u548c\u622a\u80a2\u7b49\u3002\u7cd6\u5c3f\u75c5\u53d1\u75c5\u7387\u9ad8\u3001\u9690\u533f\u6027\u5f3a\u3001\u5e76\u53d1\u75c7\u4e25\u91cd\uff0c\u8fd9\u4e09\u5927\u7279\u5f81\u4e25\u91cd\u5a01\u80c1\u7740\u4eba\u7c7b\u7684\u5065\u5eb7\u3002\u76ee\u524d\u9488\u5bf9\u7cd6\u5c3f\u75c5\u7684\u6cbb\u7597\u65b9\u6848\u8f83\u591a\uff0c\u65b0\u578b\u964d\u7cd6\u7c7b\u836f\u7269\u7684\u5f00\u53d1\u9664\u6709\u6548\u63a7\u5236\u8840\u7cd6\u5916\uff0c\u4e5f\u5728\u63a2\u7d22\u5bf9\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u51cf\u8f7b\u4f53\u91cd\u3001\u964d\u4f4e\u5fc3\u8840\u7ba1\u98ce\u9669\u3001\u4fdd\u62a4\u80be\u810f\u7b49\u65b9\u9762\u7684\u989d\u5916\u83b7\u76ca\u3002<\/p>\n<p><strong>\u5173\u4e8e\u739b\u4ed5\u5ea6\u80bd\uff08<\/strong><strong>IBI362\uff09<\/strong><\/p>\n<p>\u739b\u4ed5\u5ea6\u80bd\uff08IBI362\uff09\u662f\u4fe1\u8fbe\u751f\u7269\u4e0e\u793c\u6765\u5236\u836f\u5171\u540c\u63a8\u8fdb\u7684\u4e00\u6b3e\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08GCGR\uff09\u53cc\u91cd\u6fc0\u52a8\u5242\u3002\u4f5c\u4e3a\u4e00\u79cd\u54fa\u4e73\u52a8\u7269\u80c3\u6ccc\u9178\u8c03\u8282\u7d20\uff08OXM\uff09\u7c7b\u4f3c\u7269\uff0c\u739b\u4ed5\u5ea6\u80bd\u9664\u4e86\u901a\u8fc7\u6fc0\u52a8GLP-1R\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u51cf\u8f7b\u4f53\u91cd\u5916\uff0c\u8fd8\u53ef\u901a\u8fc7\u6fc0\u52a8GCGR\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u589e\u5f3a\u51cf\u91cd\u7597\u6548\uff0c\u540c\u65f6\u6539\u5584\u809d\u810f\u8102\u80aa\u4ee3\u8c22\u3002\u739b\u4ed5\u5ea6\u80bd\u5df2\u5728\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u4f18\u79c0\u7684\u51cf\u91cd\u548c\u964d\u7cd6\u7597\u6548\uff0c\u4ee5\u53ca\u964d\u4f4e\u8170\u56f4\u3001\u8840\u8102\u3001\u8840\u538b\u3001\u8840\u5c3f\u9178\u3001\u809d\u9176\u53ca\u809d\u810f\u8102\u80aa\u542b\u91cf\uff0c\u4ee5\u53ca\u6539\u5584\u80f0\u5c9b\u7d20\u654f\u611f\u6027\uff0c\u5e26\u6765\u591a\u91cd\u4ee3\u8c22\u83b7\u76ca\u3002\u76ee\u524d\uff0c\u739b\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\uff08GLORY-1\uff09\u53d7\u8bd5\u8005\u548c2\u578b\u7cd6\u5c3f\u75c5\uff08DREAMS-1\u548cDREAMS-2\uff09\u53d7\u8bd5\u8005\u4e2d\u7684\u4e09\u9879III\u671f\u6ce8\u518c\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\uff1b\u739b\u4ed5\u5ea6\u80bd9 mg\u5728\u4e2d\u56fd\u80a5\u80d6\u53d7\u8bd5\u8005\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\u4e8e2023\u5e74\u5e95\u542f\u52a8\u3002<\/p>\n<p><strong>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/strong><\/p>\n<p>&#8220;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&#8221;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u5df2\u670910\u4e2a\u4ea7\u54c1\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u4eec\u5206\u522b\u662f\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff09\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff09\uff0c\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff09\uff0c\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u8fbe\u4f2f\u5766<sup>&reg;<\/sup>\uff09\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<sup>&reg;<\/sup>\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u62e9<sup>&reg;<\/sup>\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u80f6\u56ca\uff08\u777f\u59a5<sup>&reg;<\/sup>\uff09\uff0c\u4f0a\u57fa\u5965\u4ed1\u8d5b\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u82cf<sup>&reg;<\/sup>\uff09\u548c\u6258\u83b1\u897f\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u4e50<sup>&reg;<\/sup>\uff09\u3002\u76ee\u524d\uff0c\u540c\u65f6\u8fd8\u67097\u4e2a\u65b0\u836f\u5206\u5b50\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670919\u4e2a\u65b0\u836f\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u516c\u53f8\u5df2\u4e0e\u793c\u6765\u3001\u7f57\u6c0f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson 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href=\"https:\/\/www.innoventbio.com\/\" rel=\"nofollow noopener\" target=\"_blank\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7<a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" rel=\"nofollow noopener\" target=\"_blank\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p>\u58f0\u660e\uff1a<em>\u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1<\/em><em>\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002<\/em><\/p>\n<p><strong>\u524d\u77bb\u6027\u58f0\u660e<\/strong><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528&#8221;\u9884\u671f&#8221;\u3001&#8221;\u76f8\u4fe1&#8221;\u3001&#8221;\u9884\u6d4b&#8221;\u3001&#8221;\u671f\u671b&#8221;\u3001&#8221;\u6253\u7b97&#8221;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde2023\u5e7411\u670822\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u91cd\u6fc0\u52a8\u5242\u739b\u4ed5\u5ea6\u80bd\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI362\uff09\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u5168\u6587\u8fd1\u65e5\u5728\u56fd\u9645\u6743\u5a01\u7cd6\u5c3f\u75c5\u671f\u520aDiabetes Care\u5728\u7ebf\u53d1\u8868\u3002 \u672c\u6587\u901a\u8baf\u4f5c\u8005\u53ca\u672c\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u65e5\u53cb\u597d\u533b\u9662\u5185\u5206\u6ccc\u79d1\u6768\u6587\u82f1\u6559\u6388\u8868\u793a\uff1a&#8221;\u76ee\u524d\uff0c\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4ecd\u5b58\u5728\u8840\u7cd6\u603b\u4f53\u8fbe\u6807\u7387\u504f\u4f4e\uff0c\u4e14\u60a3\u8005\u5f80\u5f80\u5408\u5e76\u591a\u79cd\u5fc3\u8840\u7ba1\u4ee3\u8c22\u98ce\u9669\u56e0\u7d20\uff0c\u5982\u80a5\u80d6\uff0c\u9ad8\u8102\u8840\u75c7\uff0c\u51a0\u5fc3\u75c5\uff0c\u8102\u80aa\u809d\uff0c\u75db\u98ce\u7b49\u60c5\u51b5\uff0c\u8fd9\u65e2\u589e\u52a0\u4e86\u60a3\u8005\u7684\u75be\u75c5\u8d1f\u62c5\uff0c\u4e5f\u7ed9\u4e34\u5e8a\u6cbb\u7597\u589e\u52a0\u4e86\u96be\u5ea6\u548c\u590d\u6742\u6027\u3002\u4e34\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u80fd\u6709\u7597\u6548\u786e\u5207\uff0c\u5b89\u5168\u6027\u597d\uff0c\u7ed9\u836f\u4fbf\u6377\uff0c\u4f4e\u8840\u7cd6\u98ce\u9669\u4f4e\uff0c\u4e14\u80fd\u517c\u5177\u51cf\u91cd\u4f5c\u7528\u3001\u5b9e\u73b0\u5fc3\u8840\u7ba1\u4ee3\u8c22\u591a\u91cd\u83b7\u76ca\u7684\u521b\u65b0\u836f\u7269\u3002\u5728\u6b64\u9879II\u671f\u7814\u7a76\u4e2d\uff0c\u65b0\u4e00\u4ee3GLP-1R\/GCGR\u53cc\u91cd\u6fc0\u52a8\u5242\u739b\u4ed5\u5ea6\u80bd\u4e0d\u4ec5\u5c55\u73b0\u51fa\u660e\u786e\u7684\u964d\u7cd6\u7597\u6548\uff0c\u4e14\u5728\u540c\u65f6\u964d\u4f4eHbA1c\u4e0e\u4f53\u91cd\u53cc\u9879\u6307\u6807\u4e0a\u5c55\u793a\u51fa\u4f18\u4e8eGLP-1\u5355\u9776\u836f\u7269\u5ea6\u62c9\u7cd6\u80bd\u7684\u6f5c\u8d28\uff0c\u6709\u671b\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u5408\u5e76\u80a5\u80d6\u60a3\u8005\u5e26\u6765\u989d\u5916\u83b7\u76ca\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u8fd8\u8868\u660e\uff0c\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u53d7\u8bd5\u8005\u63a5\u53d7\u739b\u4ed5\u5ea6\u80bd\u6cbb\u759720\u5468\u540e\u591a\u79cd\u5fc3\u8840\u7ba1\u4ee3\u8c22\u6307\u6807\u83b7\u76ca\u660e\u663e\uff0c\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002\u5f88\u9ad8\u5174\u770b\u5230\u7814\u7a76\u7ed3\u679c\u987a\u5229\u53d1\u8868\u4e8eDiabetes Care\uff0c\u6211\u671f\u5f85\u5728\u6b63\u5728\u8fdb\u884c\u7684\u4e24\u9879III\u671f\u7814\u7a76\u4e2d\u739b\u4ed5\u5ea6\u80bd\u53ef\u4ee5\u5c55\u73b0\u51fa\u66f4\u52a0\u60ca\u8273\u7684\u7ed3\u679c\uff0c\u5e76\u65e9\u65e5\u4e3a\u6211\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5e26\u6765\u66f4\u4f18\u7684\u6cbb\u7597\u9009\u62e9\u3002&#8221; 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mg\u7ec4\u5728\u7b2c20\u5468\u65f6\u7684HbA1c\u6c34\u5e73\u4ecd\u4fdd\u6301\u4e0b\u964d\u8d8b\u52bf\u3002\u6b64\u9879\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u7cd6\u5c3f\u75c5\u9886\u57df\u6743\u5a01\u533b\u5b66\u671f\u520a\u4e0a\uff0c\u4e00\u65b9\u9762\u8bc1\u660e\u4e86\u739b\u4ed5\u5ea6\u80bd\u4f18\u5f02\u7684\u4e34\u5e8a\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u53e6\u4e00\u65b9\u9762\u4e5f\u4f53\u73b0\u4e86\u4e2d\u56fd\u7814\u7a76\u8005\u5353\u8d8a\u7684\u4e34\u5e8a\u7814\u7a76\u6c34\u5e73\u548c\u4fe1\u8fbe\u751f\u7269\u624e\u5b9e\u7684\u7814\u53d1\u80fd\u529b\u3002\u76ee\u524d\uff0c\u739b\u4ed5\u5ea6\u80bd\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8bd5\u8005\u4e2d\u7684\u4e24\u9879III\u671f\u6ce8\u518c\u7814\u7a76\uff08DREAMS-1\u548cDREAMS-2\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5c06\u63d0\u4f9b\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u4eba\u7fa4\u4e2d\u7684\u5927\u89c4\u6a21\u6837\u672c\u91cf\u7684\u533b\u5b66\u8bc1\u636e\uff0c\u6211\u4eec\u5e0c\u671b\u8fd9\u6b3e\u9ad8\u8d28\u91cf\u836f\u7269\u65e9\u65e5\u60e0\u53ca\u4e2d\u56fd\u5e7f\u5927\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3002&#8221; 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mg\uff0c\u6bcf\u5468\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f20\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u4e3a\u7b2c20\u5468\u65f6HbA1c\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u3002\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u6b21\u7814\u7a76\u836f\u7269\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\uff08n=250\uff09\u57fa\u7ebf\u5e73\u5747BMI\u4e3a27.4 kg\/m2\uff0c\u57fa\u7ebf\u5e73\u5747HbA1c \u4e3a8.06%\u3002 \u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5404\u5242\u91cf\u739b\u4ed5\u5ea6\u80bd\u5747\u53ef\u663e\u8457\u964d\u4f4eHbA1c\u6c34\u5e73\u3002 \u7b2c20\u5468\u65f6\uff0c\u739b\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 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\u6b64\u5916\uff0c\u739b\u4ed5\u5ea6\u80bd3 mg\u30014.5 mg\u548c6 mg\u7ec4\u5206\u522b\u670916.0%\u300129.2%\u548c49.0%\u7684\u53d7\u8bd5\u8005\u7b2c20\u5468\u65f6\u4f53\u91cd\u8f83\u57fa\u7ebf\u964d\u5e45&ge;5.0%\u4e14HbA1c\uff1c7.0%\uff0c\u5ea6\u62c9\u7cd6\u80bd\u7ec4\u4e3a12.0%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a0\u3002 \u739b\u4ed5\u5ea6\u80bd\u603b\u4f53\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002 \u7814\u7a76\u6cbb\u7597\u671f\u95f4\uff0c\u739b\u4ed5\u5ea6\u80bd\u7ec4\u65e0\u53d7\u8bd5\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u63d0\u524d\u7ec8\u6b62\u7814\u7a76\u836f\u7269\u6cbb\u7597\uff0c\u65e0\u53d7\u8bd5\u8005\u53d1\u751f\u7814\u7a76\u8005\u5224\u5b9a\u4e0e\u739b\u4ed5\u5ea6\u80bd\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u7814\u7a76\u671f\u95f4\u672a\u53d1\u751f\u91cd\u5ea6\u4f4e\u8840\u7cd6\u4e8b\u4ef6\u3002 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