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\u5173\u4e8e\u6208\u5229\u6614\u66ff\u5c3c<\/b><\/p>\n

\u6208\u5229\u6614\u66ff\u5c3c\u662fT\u7ec6\u80de\u6dcb\u5df4\u7624\u9886\u57df\u5168\u7403\u9996\u4e2a\u4e14\u8fc4\u4eca\u4e3a\u6b62\u552f\u4e00\u5904\u4e8e\u5168\u7403\u6ce8\u518c\u4e34\u5e8a\u9636\u6bb5\u7684\u9ad8\u9009\u62e9\u6027JAK1\u6291\u5236\u5242\uff0c\u9996\u4e2a\u9002\u5e94\u75c7\u4e3a\u590d\u53d1\/\u96be\u6cbb\u6027\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08r\/r PTCL\uff09\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u97e9\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u7b49\u56fd\u5bb6\u5f00\u5c55\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002\u622a\u81f32023\u5e748\u670831\u65e5\uff0c\u56fd\u9645\u591a\u4e2d\u5fc3\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff08JACKPOT8 \u7684B\u90e8\u5206\uff09\u4e2d\uff0c\u6208\u5229\u6614\u66ff\u5c3c\u5355\u836f\u663e\u793a\u51fa\u5f3a\u6548\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe44.3%\uff0c\u4e14\u5176\u4e2d\u4e00\u534a\u4ee5\u4e0a\u80bf\u7624\u7f13\u89e3\u7684\u53d7\u8bd5\u8005\u8fbe\u5230\u4e86\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff0cCR\u7387\u8fbe23.9%\u3002\u6700\u957f\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u8fbe\u523018 \u4e2a\u6708\u3002\u6208\u5229\u6614\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597r\/r PTCL\uff0c\u4e8e2022\u5e742\u6708\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u201c\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\u201d\uff08Fast Track Designation\uff09\uff0c\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u4e8e2023\u5e749\u6708\u83b7\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u30022023\u5e74\u6208\u5229\u6614\u66ff\u5c3c\u7814\u7a76\u6210\u679c\u76f8\u7ee7\u5728\u56fd\u9645\u9876\u520a\u53d1\u8868\uff1a\u5168\u7403I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08JACKPOT8\u7684A\u90e8\u5206\uff09\u520a\u4e8e\u300a\u80bf\u7624\u5b66\u5e74\u9274\u300b\uff08Annals of Oncology\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a51.8\uff09\uff0cJACKPOT8\u7814\u7a76\u7684B\u90e8\u5206\u520a\u4e8e\u300a\u67f3\u53f6\u5200·\u80bf\u7624\u5b66\u300b\uff08Lancet Oncology\uff0c\u5f71\u54cd\u56e0\u5b5054.4\uff09\u3002<\/p>\n

\u5173\u4e8e<\/b>DZD8586<\/span><\/b><\/p>\n

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\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u6982\u4e0d\u627f\u62c5\uff08a\uff09\u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u4e49\u52a1\uff1b\u53ca\uff08b\uff09\u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n

\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u8054\u7cfb<\/p>\n

\u6295\u8d44\u8005\u5173\u7cfb\uff1air@dizalpharma.com <\/a>
\u5546\u52a1\u5408\u4f5c\uff1abd@dizalpharma.com <\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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exon20ins\uff09\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u2014\u2014\u72ec\u7acb\u5f71\u50cf\u8bc4\u4f30\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636eRECIST 1.1\u8bc4\u4f30\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe61%\uff0c\u4e14\u5728\u591a\u79cdEGFR exon20ins\u7a81\u53d8\u4e9a\u578b\u4e2d\u5747\u89c2\u5bdf\u5230\u660e\u786e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u8212\u6c83\u54f2®\u5728 EGFR\u654f\u611f\u7a81\u53d8\u3001T790M\u7a81\u53d8\u3001\u5176\u4ed6EGFR\u7a81\u53d8\u4e9a\u578b\uff08\u5982G719X\u3001L861Q\u7b49\uff09\u548c HER2 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u4e5f\u89c2\u5bdf\u5230\u521d\u6b65\u7597\u6548\u3002\u8212\u6c83\u54f2®\u7684\u8f6c\u5316\u79d1\u5b66\u7814\u7a76\u6210\u679c\uff0c\u4e8e2022\u5e744\u6708\u8363\u767b\u56fd\u9645\u9876\u7ea7\u671f\u520aCancer Discovery\uff08\u5f71\u54cd\u56e0\u5b50\uff1a39.397\uff09\u3002 \u5173\u4e8e\u6208\u5229\u6614\u66ff\u5c3c \u6208\u5229\u6614\u66ff\u5c3c\u662fT\u7ec6\u80de\u6dcb\u5df4\u7624\u9886\u57df\u5168\u7403\u9996\u4e2a\u4e14\u8fc4\u4eca\u4e3a\u6b62\u552f\u4e00\u5904\u4e8e\u5168\u7403\u6ce8\u518c\u4e34\u5e8a\u9636\u6bb5\u7684\u9ad8\u9009\u62e9\u6027JAK1\u6291\u5236\u5242\uff0c\u9996\u4e2a\u9002\u5e94\u75c7\u4e3a\u590d\u53d1\/\u96be\u6cbb\u6027\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08r\/r PTCL\uff09\uff0c\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u97e9\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u7b49\u56fd\u5bb6\u5f00\u5c55\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002\u622a\u81f32023\u5e748\u670831\u65e5\uff0c\u56fd\u9645\u591a\u4e2d\u5fc3\u5173\u952e\u6027\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff08JACKPOT8 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