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border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prnvab prnpl2 prnpr2 prnsbtb0 prnrbrb0 prnsbbb0 prnsblb0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[1] Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K. A., McGowan, S. J., Burrack, A. L., Wang, D., Dong, Q., Lu, A., Sano, T., O&#8217;Kelly, R. D., McGuckian, C. A., Kato, J. I., Bank, M. P., Wade, E. A., \u2026 Niedernhofer, L. J. (2021). An aged immune system drives senescence and ageing of solid organs. Nature, 594(7861), 100\u2013105. <a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03547-7\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1038\/s41586-021-03547-7<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u82cf\u5dde2023\u5e7411\u670820\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 2023\u5e7411\u670820\u65e5\uff0c\u82cf\u5dde\u535a\u817e\u751f\u7269\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u535a\u817e\u751f\u7269\uff09\u5ba3\u5e03\u4e0e\u963f\u601d\u79d1\u529b\uff08\u82cf\u5dde\uff09\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u963f\u601d\u79d1\u529b\uff09\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u52a8NK\u7ec6\u80de\u7684\u5f00\u53d1\u4e0e\u751f\u4ea7\uff0c\u52a9\u529b\u57fa\u56e0\u4e0e\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684\u53d1\u5c55\u548c\u521b\u65b0\uff0c\u52a0\u5febNK\u7ec6\u80de\u5728\u9632\u764c\u7f8e\u5bb9\u6297\u8870\u9886\u57df\u7684\u5e94\u7528\u3002 \u535a\u817e\u751f\u7269\u81f4\u529b\u4e8e\u63d0\u4f9b\u7aef\u5230\u7aef\u7684\u57fa\u56e0\u4e0e\u7ec6\u80de\u6cbb\u7597CDMO\u670d\u52a1\uff0c\u8986\u76d6\u8d28\u7c92\u3001\u7ec6\u80de\u6cbb\u7597\u3001\u57fa\u56e0\u6cbb\u7597\u3001\u6eb6\u7624\u75c5\u6bd2\u3001\u6838\u9178\u6cbb\u7597\u53ca\u6d3b\u83cc\u7597\u6cd5\u7b49\u9886\u57df\uff0c\u76ee\u524d\u5df2\u6210\u529f\u5e2e\u52a9\u5ba2\u6237\u5b8c\u6210\u591a\u4e2a\u57fa\u56e0\u4e0e\u7ec6\u80de\u6cbb\u7597\u836f\u7269\u7684CMC\u548c\u5168\u7403\u7533\u62a5\u670d\u52a1\u3002\u963f\u601d\u79d1\u529b\u4e13\u6ce8\u4e8e\u7a81\u7834\u6027\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7814\u53d1\u4e0e\u751f\u4ea7\uff0c\u4e3b\u8981\u805a\u7126NK\/CAR-NK\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u836f\u7269\u9886\u57df\uff0c\u5e76\u642d\u5efa\u4e86\u5b8c\u5584\u7684\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u751f\u4ea7\u4f53\u7cfb\uff0c\u5177\u6709\u901a\u7528\u578bCAR-NK\u3001\u5f02\u4f53NK\/CAR-NK\u548cmRNA-LNP\u4e09\u5927\u6280\u672f\u5e73\u53f0\u3002\u636e\u534f\u8bae\uff0c\u535a\u817e\u751f\u7269\u5c06\u4e3a\u963f\u601d\u79d1\u529bNK\u7ec6\u80de\u9879\u76ee\u63d0\u4f9b\u5f00\u53d1\u4e0e\u751f\u4ea7\u53ca\u4e2d\u56fd\u7533\u62a5\u670d\u52a1\uff0c\u652f\u6301\u5176\u5728\u9632\u764c\u6297\u8870\u7f8e\u5bb9\u7b49\u9886\u57df\u7684\u5e94\u7528\u3002 \u963f\u601d\u79d1\u529b\u521b\u59cb\u4eba\u517c\u8463\u4e8b\u957f\u674e\u534e\u987a\u535a\u58eb\u8868\u793a\uff1a&quot;CAR-NK\u7ec6\u80de\u7597\u6cd5\u5728\u6297\u764c\u65b9\u9762\u5177\u6709\u6f5c\u529b\u3002\u8fd9\u79cd\u7597\u6cd5\u901a\u8fc7\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u4fee\u9970NK\u7ec6\u80de\uff0c\u4f7f\u5176\u80fd\u591f\u66f4\u597d\u5730\u8bc6\u522b\u548c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u540c\u65f6\u964d\u4f4e\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u4f24\u5bb3\u3002\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u9886\u57df\uff0cCAR-NK\u7ec6\u80de\u7597\u6cd5\u5177\u6709\u4f18\u52bf\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u5728\u6297\u8870\u65b9\u9762\uff0c\u5355\u5242\u91cf20\u4ebf\u5e74\u8f7b\u5065\u5eb7\u7ec6\u80de\u53ef\u4ee5\u964d\u4f4e\u5faa\u73af\u4e2d\u8870\u8001\u7ec6\u80de\u9ad8\u8fbe80%-100%[1]&nbsp;\uff0c\u4e14\u6301\u7eed\u6548\u7387\u8d85\u8fc73\u4e2a\u6708\u523018\u4e2a\u6708\u4e4b\u4e45\u3002\u963f\u601d\u79d1\u529b\u5728NK\u9886\u57df\u5177\u6709\u6df1\u539a\u79ef\u6dc0\u548c\u5de5\u827a\u4f18\u52bf\uff0c\u6211\u4eec\u6253\u9020\u4e86Ascle-NK\u5e73\u53f0\u57f9\u517b\u51fa\u5353\u8d8a\u8d85\u80fd\u7684NK\u7ec6\u80de\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u535a\u817e\u751f\u7269\u5728\u57fa\u56e0\u4e0e\u7ec6\u80de\u6cbb\u7597\u836f\u7269\u7684\u7814\u53d1\u3001\u751f\u4ea7\u4ee5\u53ca\u9879\u76ee\u7533\u62a5\u65b9\u9762\u53d6\u5f97\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u6210\u5c31\u3002\u6211\u76f8\u4fe1\u51ed\u501f\u5176\u4e30\u5bcc\u7684\u7ecf\u9a8c\u548c\u4e13\u4e1a\u6280\u672f\uff0c\u535a\u817e\u751f\u7269\u80fd\u591f\u4e3a\u963f\u601d\u79d1\u529b\u63a8\u52a8NK\u7ec6\u80de\u5728\u6297\u8870\u7f8e\u5bb9\u9632\u764c\u7b49\u9886\u57df\u7684\u5e94\u7528\u63d0\u4f9b\u91cd\u8981\u652f\u6301\u3002&quot; 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[1] Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K. A., McGowan, S. J., Burrack, A. L., Wang, D., Dong, Q., Lu, A., Sano, T., O&#8217;Kelly, R. D., McGuckian, C. A., Kato, J. I.,&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2023112013120098244\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":98247,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-98244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/98244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=98244"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/98244\/revisions"}],"predecessor-version":[{"id":98246,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/98244\/revisions\/98246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/98247"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=98244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=98244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=98244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}