{"id":97501,"date":"2023-11-14T05:40:00","date_gmt":"2023-11-13T22:40:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023111405400097501"},"modified":"2023-11-14T22:03:16","modified_gmt":"2023-11-14T14:03:16","slug":"%e8%85%be%e7%9b%9b%e5%8d%9a%e8%8d%af%e5%9c%a82023%e5%b9%b4%e7%be%8e%e5%9b%bd%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a%ef%bc%88aasld%ef%bc%89%e4%b8%8a%e5%8f%91%e5%b8%83","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023111405400097501","title":{"rendered":"\u817e\u76db\u535a\u836f\u57282023\u5e74\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\uff08AASLD\uff09\u4e0a\u53d1\u5e03\u6700\u65b0\u6570\u636e\uff0c\u5f3a\u8c03\u5728\u5b9e\u73b0HBV\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u9762\u7684\u8fdb\u5c55"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Logo-532.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p><i>\u76f4\u63a5\u8bc1\u636e\u663e\u793a\uff0c<\/i><i>BRII-179\u8bf1\u5bfc\u7684\u529f\u80fd\u6027\u6297\u4f53\u5e94\u7b54\u6709\u52a9\u4e8e\u63d0\u9ad8\u548c\u7ef4\u6301HBsAg\u6e05\u9664\u7387<\/i><\/p>\n<p><i>\u5728\u5229\u7528<\/i><i>BRII-179\u5bcc\u96c6\u5177\u6709\u5185\u5728\u4f53\u6db2\u514d\u75ab\u5e94\u7b54\u7684\u60a3\u8005\u4ee5\u63d0\u9ad8HBsAg\u6e05\u9664\u7387\u6216HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u65b9\u9762\u83b7\u5f97\u65b0\u7684\u6d1e\u5bdf<\/i><\/p>\n<p><i>\u65b0\u6570\u636e\u652f\u6301\u8fdb\u5165\u540e\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u8fd9\u4e9b\u6570\u636e\u6709\u671b\u4e3a\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u6cbb\u6108\u6027\u7597\u6cd5\u63d0\u4f9b\u4f9d\u636e<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u5317\u4eac\u7f8e\u56fd\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c6<\/span><span class=\"legendSpanClass\">2023\u5e7411\u670814\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;<a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow noopener\">\u817e\u76db\u535a\u836f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08&quot;\u817e\u76db\u535a\u836f&quot;\u6216&quot;\u516c\u53f8&quot;\uff0c\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u9488\u5bf9\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\u4ee5\u53ca\u91cd\u5927\u516c\u5171\u536b\u751f\u6027\u75be\u75c5\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u7684\u8de8\u56fd\u4f01\u4e1a\uff0c\u4eca\u65e5\u5728\u9a6c\u8428\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f\u4e3e\u884c\u7684\u7f8e\u56fd\u809d\u75c5\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\uff08AASLD\uff09\u4e0a\u5206\u4eab\u4e86\u4e09\u5f20\u58c1\u62a5\uff0c\u5176\u4e2d\u4e24\u5f20\u58c1\u62a5\u4e3a\u6700\u65b0\u7a81\u7834\u58c1\u62a5\uff0c\u63d0\u4f9b\u4e86\u6162\u6027\u4e59\u578b\u809d\u708e\uff08CHB\uff09\u4e34\u5e8a\u9879\u76ee\u4e2d\u7684\u4e24\u9879\u5904\u4e8e2\u671f\u7814\u53d1\u9636\u6bb5\u7684\u4ea7\u54c1BRII-179\uff08VBI-2601\uff09\u548cBRII-835\uff08VIR-2218\uff09\u7684\u6700\u65b0\u6570\u636e\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u817e\u76db\u535a\u836f\u9996\u5e2d\u533b\u5b66\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a&quot;\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u5728\u809d\u75c5\u5e74\u4f1a\u4e0a\u5206\u4eab\u8fd9\u4e9b\u6570\u636e\u3002\u8fd9\u4e9b\u6570\u636e\u8bc1\u5b9e\u6211\u4eecHBV\u7ba1\u7ebf\u7ec4\u5408\u7684\u591a\u529f\u80fd\u6027\uff0c\u5e76\u5c55\u793a\u4e86\u6211\u4eec\u5728\u5bfb\u627eHBV\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6cd5\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u6d1e\u89c1\u3002HBsAg\u6e05\u9664\u4e0e\u6297\u4f53\u5e94\u7b54\u4e4b\u95f4\u7684\u91cd\u8981\u8054\u7cfb\uff0c\u4e3a\u8fdb\u4e00\u6b65\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7387\u548c\u8bc6\u522b\u6700\u6709\u53ef\u80fd\u5bf9\u6cbb\u6108\u6027\u7597\u6cd5\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u6307\u660e\u4e86\u65b9\u5411\u3002\u6211\u4eec\u7684\u76ee\u6807\u662f\u5728\u5c3d\u53ef\u80fd\u5e7f\u6cdb\u7684\u4eba\u7fa4\u4e2d\u4e3a\u5408\u9002\u7684\u60a3\u8005\u5f00\u53d1\u9002\u5f53\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u540c\u65f6\u8ba9\u60a3\u8005\u907f\u514d\u9009\u62e9\u6602\u8d35\u6216\u8010\u53d7\u6027\u8f83\u5dee\u4e14\u4e0d\u4f1a\u7ed9\u4ed6\u4eec\u5e26\u6765\u83b7\u76ca\u7684\u6cbb\u7597\u9009\u62e9\u3002&quot;<\/p>\n<p>\u5728\u6700\u65b0<a href=\"https:\/\/www.briibio.com\/media\/pjzdkb2t\/1-aasld-poster-brii-179-002.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u7a81\u7834\u58c1\u62a5\u62a5\u544a<\/a>\u4e2d\uff0c\u817e\u76db\u535a\u836f\u516c\u5e03\u4e86BRII-179\u8054\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u6cbb\u7597CHB\u60a3\u8005\u7684\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u548c\u53cc\u76f2\u76842\u671f\u7814\u7a76\u6cbb\u7597\u7ec4\u522b\u5c42\u9762\u63ed\u76f2\u7684\u8fdb\u4e00\u6b65\u6570\u636e\u3002\u62a5\u544a\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5728\u73b0\u6709PEG-IFN\u03b1\u6cbb\u7597\u57fa\u7840\u4e0a\u8054\u5408BRII-179\u603b\u4f53\u4e0a\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u5176\u4e0d\u826f\u4e8b\u4ef6\u4e0e\u65e2\u5f80\u62a5\u9053\u7684PEG-IFN\u03b1\u6cbb\u7597\u548cBRII-179\u7684\u4e0d\u826f\u4e8b\u4ef6\u76f8\u4f3c\u3002<\/li>\n<li>\u5728\u7b2c36\u5468\uff08\u6cbb\u7597\u7ed3\u675f\u540e [EOT] 12\u5468\uff09\uff0c\u4e0e\u5b89\u6170\u5242 + PEG-IFN\u03b1\u7ec4\u76f8\u6bd4\uff0cBRII-179 + PEG-IFN\u03b1\u7ec4\u7684HBsAg\u6e05\u9664\u7387\u66f4\u9ad8\uff08\u5168\u5206\u6790\u96c6 [FAS]\uff1a24.6% vs. 14.0%\uff0c\u7b26\u5408\u65b9\u6848\u96c6 [PPS]\uff1a31.8% vs. 14.9%\uff09\u3002\u5728\u7b2c24\u5468\uff08EOT\uff09\u5df2\u89c2\u5bdf\u5230\u8be5HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u5dee\u5f02\uff0c\u8fd9\u79cd\u5dee\u5f02\u4e00\u76f4\u7ef4\u6301\u5230\u7b2c36\u5468\u3002\u4e34\u5e8a\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u5728\u7b2c24\u5468\uff08EOT\uff09\uff0c\u8054\u5408\u7ed9\u836f\u7ec4\u7684HBsAg\u8840\u6e05\u5b66\u8f6c\u6362\u7387\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242 + PEG-IFN\u03b1\u7ec4\uff08FAS\uff1a15.8% vs. 1.8%\uff0c<i>p=0.0163<\/i>\uff1bPPS\uff1a19.6% vs. 2.0%\uff0c<i>p=0.0058<\/i>\uff09\u3002<\/li>\n<li>\u8054\u5408BRII-179\u53ef\u8bf1\u5bfc\u9488\u5bf9HBsAg\u7684\u7a33\u5065\u7684\u3001\u529f\u80fd\u6027\u7684\u6297\u4f53\u5e94\u7b54\u3002BRII-179 + PEG-IFN\u03b1\u8054\u5408\u7ed9\u836f\u7ec4\u7684\u53d7\u8bd5\u8005\u5728\u7b2c24\u5468\u548c\u7b2c36\u5468\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u4f53\uff08HBsAb\uff09\u5e94\u7b54\u7387\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242 + PEG-IFN\u03b1\u7ec4\uff08\u7b2c24\u5468FAS\uff1a38.6% vs. 14.0%\uff0c<i>p=0.0052<\/i>\uff1bPPS\uff1a39.1% vs. 13.7%\uff0c<i>p=0.0054<\/i>\uff1b\u7b2c36\u5468FAS\uff1a33.3% vs. 12.3%\uff0c<i>p=0.0131<\/i>\uff1bPPS\uff1a34.1% vs. 10.6%\uff0c<i>p=0.0105<\/i>\uff09\u3002\u5728\u7b2c24\u5468\u548c\u7b2c36\u5468\uff0cHBsAb\u6ef4\u5ea6\u4e0eHBsAg\u6e05\u9664\u663e\u8457\u76f8\u5173\uff0cHBsAg\u53cd\u5f39\u76845\u4f8b\u60a3\u8005\u4e2d\u67094\u4f8b\u68c0\u6d4b\u4e0d\u5230\u6297\u4f53\u5e94\u7b54\u3002<\/li>\n<li>\u8fd9\u9879\u6982\u5ff5\u9a8c\u8bc1\u6027\u7814\u7a76\u7684\u6570\u636e\u8868\u660e\uff0c\u8054\u5408BRII-179\u53ef\u8bf1\u5bfc\u529f\u80fd\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u63d0\u9ad8\u63a5\u53d7PEG-IFN\u03b1\u6cbb\u7597\u7684CHB\u60a3\u8005\u7684HBsAg\u6e05\u9664\u7387\u548c\u6e05\u9664\u6301\u7eed\u65f6\u95f4\uff0c\u8fdb\u800c\u63d0\u9ad8CHB\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002<\/li>\n<\/ul>\n<p>\u5728\u7b2c\u4e8c\u5f20\u6700\u65b0<a href=\"https:\/\/www.briibio.com\/media\/qrlnl304\/2-aasld-poster-brii-179-835-001.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u7a81\u7834\u58c1\u62a5\u62a5\u544a<\/a>\u4e2d\uff0c\u817e\u76db\u535a\u836f\u5c55\u793a\u4e86BRII-179-001\u548cBRII-179-835-001\u7814\u7a76\u7684\u8f6c\u5316\u7814\u7a76\u6570\u636e\uff0c\u8868\u660e\u4ec5\u5728\u90e8\u5206CHB\u53d7\u8bd5\u8005\u4e2d\u89c2\u5bdf\u5230BRII-179\u53ef\u8bf1\u5bfc\u72ec\u7279\u7684HBsAg\u6297\u4f53\u5e94\u7b54\uff0c\u8fd9\u8bf4\u660e\u4e00\u4e9b\u60a3\u8005\u5bf9HBV\u7684\u5185\u5728\u514d\u75ab\u5e94\u7b54\u53ef\u80fd\u53d7\u5230\u4e86\u66f4\u4e25\u91cd\u7684\u635f\u5bb3\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\uff1a<\/p>\n<ul type=\"disc\">\n<li>BRII-179\u8054\u5408BRII-835\uff08VIR-2218\uff09\u6bcf\u6708\u4e00\u6b21\u7ed9\u836f\uff0c\u8fde\u7eed\u7ed9\u836f9\u4e2a\u6708\u7684\u8010\u53d7\u6027\u603b\u4f53\u826f\u597d\uff0c\u6ca1\u6709\u53d1\u751f2\u7ea7\u4ee5\u4e0a\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002<\/li>\n<li>\u5728\u63a5\u53d7\u6838\u82f7\uff08\u9178\uff09\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\uff08NrtI\uff09\u6cbb\u7597\u7684CHB\u53d7\u8bd5\u8005\u4e2d\uff0cBRII-179\u5355\u836f\u6cbb\u7597\u6216\u8054\u5408BRII-835\u6cbb\u7597\u5747\u53ef\u8bf1\u5bfc\u4ea7\u751f\u663e\u8457\u7684HBV\u7279\u5f02\u6027T\u7ec6\u80de\u5e94\u7b54\uff0c\u800c\u4ec5\u5728\u90e8\u5206CHB\u53d7\u8bd5\u8005\u4e2d\uff0c\u5728\u4e0eBRII-835\u8054\u5408\u63a5\u79cd9\u5242\u540e\uff08\u4e00\u79cdHBV\u9776\u5411siRNA\uff0c\u53ef\u964d\u4f4e\u514d\u75ab\u6291\u5236\u6027\u75c5\u6bd2\u6297\u539f\u5982HBsAg\uff09\uff0c\u5f15\u8d77\u663e\u8457\u7684\u6297HBsAg\u6297\u4f53\u5e94\u7b54\u3002<\/li>\n<li>\u514d\u75ab\u5206\u6790\u8868\u660e\uff0cBRII-179\u53ef\u4ee5\u63d0\u4f9b\u4e00\u4e2a\u72ec\u7279\u7684\u673a\u4f1a\uff0c\u53ef\u4ee5\u5bcc\u96c6\u80fd\u591f\u4ea7\u751f\u5fc5\u8981\u7684\u6297HBsAg\u6297\u4f53\u5e94\u7b54\u7684CHB\u60a3\u8005\uff0c\u5728\u4e00\u4e9b\u60a3\u8005\u4e2d\u5b9e\u73b0\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u540c\u65f6\u907f\u514d\u5176\u4ed6\u60a3\u8005\u63a5\u53d7\u4e0d\u5fc5\u8981\u7684\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p>\u5728\u53e6\u4e00\u4e2a<a href=\"https:\/\/www.briibio.com\/media\/iyshdux0\/3-aasld-poster-vir-2218-pk.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u58c1\u62a5\u62a5\u544a<\/a>\u4e2d\uff0c\u817e\u76db\u535a\u836f\u91cd\u70b9\u4ecb\u7ecd\u4e861b\/2\u671f\u548c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2dBRII-835\uff08VIR-2218\uff09\u5728\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u7684\u591a\u6b21\u7ed9\u836f\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\uff0c\u4ee5\u53ca\u533a\u57df\u6216\u79cd\u65cf\u80cc\u666f\u53ef\u80fd\u5bf9\u836f\u7269PK\u4ea7\u751f\u7684\u5f71\u54cd\u3002\u91cd\u70b9\u5185\u5bb9\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>BRII-835\u5728\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u7684PK\u7279\u6027\u4e0e\u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u7684PK\u7279\u6027\u57fa\u672c\u76f8\u4f3c\u3002\u5242\u91cf\u4e3a50 mg\u548c100 mg\u65f6\uff0c\u89c2\u5bdf\u5230\u5168\u8eab\u66b4\u9732\u91cf\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u589e\u52a0\u3002\u56db\u5468\u540e\u7b2c2\u6b21\u7ed9\u836f\u540e\uff0c\u8840\u6d46\u4e2d\u65e0\u660e\u663e\u84c4\u79ef\u3002<\/li>\n<li>\u4e9a\u592a\u5730\u533a\u548c\u4e2d\u56fd\u5927\u9646\u5165\u7ec4\u60a3\u8005\u7684PK\u7279\u5f81\u76f8\u4f3c\uff0c\u8868\u660e\u6765\u81ea\u4e2d\u56fd\u5927\u9646\u7684\u4e2d\u56fd\u60a3\u8005\u7684\u79cd\u65cf\u80cc\u666f\u672a\u4ea7\u751f\u663e\u8457\u5f71\u54cd\uff0c\u8fd9\u53ef\u4ee5\u652f\u6301\u4e2d\u56fd\u5927\u9646\u53c2\u4e0e\u672a\u6765\u5168\u7403\u8bd5\u9a8c\uff0c\u4ee5\u8fdb\u4e00\u6b65\u8bc4\u4f30BRII-835\u3002<\/li>\n<\/ul>\n<p>\u4f5c\u4e3a\u817e\u76db\u535a\u836f\u5f00\u53d1HBV\u529f\u80fd\u6027\u6cbb\u6108\u72ec\u7279\u65b9\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u4e0e\u5176\u5408\u4f5c\u4f19\u4f34\u6b63\u5728\u8fdb\u884c\u591a\u9879\u4e34\u5e8a2\u671f\u7814\u7a76\uff0c\u5305\u62ecBRII-835\u548cBRII-179\u8054\u5408\u7528\u836f\u3001BRII-179\u548cPEG-IFN\u237a\u8054\u5408\u7528\u836f\u3001BRII-835\u3001BRII-877\uff08VIR-3434\uff09\u8054\u5408\u6216\u4e0d\u8054\u5408PEG-IFN\u237a\u3002\u6b64\u5916\uff0cVir Biotechnology, Inc.\uff08&quot;Vir&quot;\uff09\u8fd8\u5728\u7814\u7a76VIR-2218\u548c\/\u6216VIR-3434\u7528\u4e8e\u6cbb\u7597HBV\/HDV\u5408\u5e76\u611f\u67d3\u3002<\/p>\n<p><b>\u5173\u4e8e\u4e59\u578b\u809d\u708e<br \/><\/b>\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u80c1\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6570\u8d85\u8fc72.9\u4ebf\u3002<sup>1<\/sup>\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u810f\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7ea6\u670982\u4e07\u4eba\u6b7b\u4e8e\u6162\u6027HBV\u611f\u67d3\u7684\u5e76\u53d1\u75c7\u3002<sup>1<\/sup>\u4e2d\u56fd\u6162\u6027HBV\u611f\u67d3\u4eba\u6570\u8fbe8,700\u4e07\uff0c\u975e\u5e38\u503c\u5f97\u5173\u6ce8\u3002<sup>2<\/sup><\/p>\n<p><b>\u5173\u4e8e<\/b><b>BRII-179<br \/><\/b>BRII-179\uff08VBI-2601\uff09\u662f\u4e00\u79cd\u57fa\u4e8e\u91cd\u7ec4\u86cb\u767d\u8d28\u7684\u65b0\u578bHBV \u514d\u75ab\u6cbb\u7597\u5019\u9009\u836f\u7269\uff0c\u53ef\u8868\u8fbePre-S1\u3001Pre-S2\u548cS HBV\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8bf1\u5bfc\u589e\u5f3a\u548c\u5e7f\u6cdb\u7684B\u7ec6\u80de\u548cT\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\u3002\u4f5c\u4e3a\u6cbb\u7597\u6162\u6027HBV\u611f\u67d3\u7684\u6f5c\u5728\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\u7684\u4e00\u90e8\u5206\uff0c\u817e\u76db\u535a\u836f\u6b63\u5728\u5f00\u5c55BRII-179\u4e0eBRII-835\uff08VIR-2218\uff09\u8054\u5408\u7528\u836f\uff0c\u53caBRII-179\u4e0ePEG-IFN\u03b1\u8054\u5408\u7528\u836f\u7684\u4e24\u98792\u671f\u7814\u7a76\u3002<\/p>\n<p>\u817e\u76db\u535a\u836f\u4e8e2018\u5e7412\u6708\u4eceVBI Vaccines, Inc.\uff08&quot;VBI&quot;\uff09\u5f15\u8fdb\u4e86BRII-179\uff0c\u83b7\u5f97\u4e86\u5728\u5305\u62ec\u4e2d\u56fd\u5927\u9646\uff0c\u9999\u6e2f\uff0c\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\u7684\u5546\u4e1a\u5316\u6743\u76ca\u3002\u516c\u53f8\u8fd8\u81ea2023\u5e747\u6708\u8d77\uff0c\u5c06BRII-179\u7684\u72ec\u5bb6\u8bb8\u53ef\u6269\u5c55\u81f3\u5168\u7403\u5e02\u573a\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>BRII-835<br \/><\/b>BRII-835\uff08VIR-2218\uff09\u662f\u4e00\u79cd\u7ecf\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\u7684\u9776\u5411HBV\u7684siRNA\u7814\u7a76\u6027\u836f\u7269\uff0c\u5177\u6709\u5bf9HBV\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u548c\u8bf1\u5bfc\u6709\u6548\u514d\u75ab\u5e94\u7b54\u7684\u6f5c\u529b\u3002\u5b83\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684\u91c7\u7528\u589e\u5f3a\u578b\u7a33\u5b9a\u5316\u5b66+\uff08ESC+\uff09\u6280\u672f\u7684siRNA\uff0c\u53ef\u589e\u5f3a\u7a33\u5b9a\u6027\u5e76\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u8131\u9776\u6548\u5e94\uff0c\u4ece\u800c\u53ef\u63d0\u5347\u6cbb\u7597\u6548\u529b\u3002\u817e\u76db\u535a\u836f\u4e8e2020\u5e74\u4eceVir Biotechnology, Inc.\uff08&quot;Vir&quot;\uff09\u83b7\u5f97\u4e86\u5728\u5927\u4e2d\u534e\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316BRII-835\u7684\u4e13\u6709\u6743\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b> BRII-877<br \/><\/b>BRII-877\uff08VIR-3434\uff09\u662f\u4e00\u79cd\u76ae\u4e0b\u6ce8\u5c04\u7684\u7814\u7a76\u6027HBV\u4e2d\u548c\u5355\u514b\u9686\u6297\u4f53\uff0c\u65e8\u5728\u963b\u65ad\u6240\u670910\u79cd\u57fa\u56e0\u578b\u7684HBV\u8fdb\u5165\u809d\u7ec6\u80de\uff0c\u5e76\u964d\u4f4e\u8840\u6db2\u4e2d\u75c5\u6bd2\u9897\u7c92\u548c\u4e9a\u75c5\u6bd2\u9897\u7c92\u7684\u6c34\u5e73\u3002BRII-877\uff08VIR-3434\uff09\u7ed3\u5408\u4e86Xencor\u7684Xtend &#x2122;\u548c\u5176\u4ed6Fc\u6280\u672f\uff0c\u901a\u8fc7\u8fd9\u4e9b\u6539\u9020\u6709\u5e0c\u671b\u5728\u611f\u67d3\u60a3\u8005\u4e2d\u4f5c\u4e3a\u9488\u5bf9HBV\u7684T\u7ec6\u80de\u75ab\u82d7\uff0c\u5e76\u5177\u6709\u5ef6\u957f\u7684\u534a\u8870\u671f\u3002\u817e\u76db\u535a\u836f\u4e8e2022\u5e74\u4eceVir Biotechnology, Inc.\uff08&quot;Vir&quot;\uff09\u83b7\u5f97\u4e86BRII-877\u5728\u5927\u4e2d\u534e\u533a\u7684\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u76ca\u3002<\/p>\n<p><b>\u5173\u4e8e\u817e\u76db\u535a\u836f<br \/><\/b>\u817e\u76db\u535a\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u9488\u5bf9\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6ee1\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3001\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4ee5\u53ca\u7ed9\u60a3\u8005\u5e26\u6765\u4e25\u91cd\u793e\u4f1a\u6b67\u89c6\u7684\u91cd\u5927\u516c\u5171\u536b\u751f\u6311\u6218\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u3002\u516c\u53f8\u4e13\u6ce8\u4e8e\u611f\u67d3\u6027\u75be\u75c5\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u6b63\u5728\u63a8\u8fdb\u4e00\u6761\u6db5\u76d6\u591a\u79cd\u72ec\u7279\u5019\u9009\u836f\u7269\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5e76\u901a\u8fc7\u9886\u5148\u7684\u9879\u76ee\u5f00\u53d1\u9488\u5bf9\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u65b0\u578b\u529f\u80fd\u6027\u6cbb\u6108\u65b9\u6848\uff0c\u548c\u9488\u5bf9\u4ea7\u540e\u6291\u90c1\u75c7\uff08PPD\uff09\u4ee5\u53ca\u91cd\u5ea6\u6291\u90c1\u75c7\uff08MDD\uff09\u7684\u9996\u521b\u6cbb\u7597\u65b9\u6848\u3002\u5728\u5bcc\u6709\u8fdc\u89c1\u5353\u8bc6\u548c\u7ecf\u9a8c\u4e30\u5bcc\u7684\u9886\u5bfc\u56e2\u961f\u5e26\u9886\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u4e8e\u7f57\u5229-\u8fbe\u52d2\u59c6\u3001\u65e7\u91d1\u5c71\u6e7e\u533a\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u672f\u4e2d\u5fc3\u5f00\u5c55\u4e1a\u52a1\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.briibio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.briibio.com<\/a>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>1&nbsp;World Health Organization. (<span class=\"xn-chron\">June 2022<\/span>). <i>Hepatitis B.<\/i> World Health Organization. Retrieved from <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b<\/a><br \/>2&nbsp;World Health Organization. <i>Hepatitis.<\/i> World Health Organization. Retrieved from <a href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a>.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u76f4\u63a5\u8bc1\u636e\u663e\u793a\uff0cBRII-179\u8bf1\u5bfc\u7684\u529f\u80fd\u6027\u6297\u4f53\u5e94\u7b54\u6709\u52a9\u4e8e\u63d0\u9ad8\u548c\u7ef4\u6301HBsAg\u6e05\u9664\u7387 \u5728\u5229\u7528BRII-179\u5bcc\u96c6\u5177\u6709\u5185\u5728\u4f53\u6db2\u514d\u75ab\u5e94\u7b54\u7684\u60a3\u8005\u4ee5\u63d0\u9ad8HBsAg\u6e05\u9664\u7387\u6216HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u65b9\u9762\u83b7\u5f97\u65b0\u7684\u6d1e\u5bdf \u65b0\u6570\u636e\u652f\u6301\u8fdb\u5165\u540e\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u8fd9\u4e9b\u6570\u636e\u6709\u671b\u4e3a\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u6cbb\u6108\u6027\u7597\u6cd5\u63d0\u4f9b\u4f9d\u636e \u5317\u4eac\u7f8e\u56fd\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u8fbe\u52d2\u59c62023\u5e7411\u670814\u65e5 \/\u7f8e\u901a\u793e\/ 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