{"id":97090,"date":"2023-10-12T13:39:00","date_gmt":"2023-10-12T06:39:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023101213390097090"},"modified":"2023-10-13T17:41:49","modified_gmt":"2023-10-13T09:41:49","slug":"%e7%a7%91%e6%b5%8e%e8%8d%af%e4%b8%9a%e9%9d%b6%e5%90%91gpc3-car-t%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9f%e8%82%9d%e7%bb%86%e8%83%9e%e7%99%8c%ef%bc%9a%e4%b8%a4%e4%be%8b%e9%80%be7%e5%b9%b4","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023101213390097090","title":{"rendered":"\u79d1\u6d4e\u836f\u4e1a\u9776\u5411GPC3 CAR-T\u7ec6\u80de\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\uff1a\u4e24\u4f8b\u903e7\u5e74\u65e0\u75c5\u751f\u5b58"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Logo-526.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e7410\u670812\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; <span id=\"spanHghlt9ef4\">\u79d1\u6d4e\u836f\u4e1a<\/span>\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\uff0c\u4e00\u5bb6\u4e3b\u8981\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u516c\u53f8\uff0c\u5ba3\u5e03\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u9776\u5411GPC3\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u4e24\u4f8b\u957f\u671f\u65e0\u75c5\u751f\u5b58\u6848\u4f8b\u5df2\u5728\u300aCancer Communications\u300b\u6742\u5fd7\u53d1\u8868\u5e76\u88ab\u5f55\u7528\u4e3a\u5f53\u671f\u5c01\u9762\u8bba\u6587\uff0c\u9898\u4e3a\u201cCombined local therapy and CAR-GPC3 T-cell therapy in advanced hepatocellular carcinoma: a proof-of-concept treatment strategy\u201d\u3002\uff08https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cac2.12472\uff09<sup>[1]<\/sup>\u3002<\/p>\n<p><span>\u809d\u764c\u662f\u6211\u56fd\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u53d1\u75c5\u548c\u6b7b\u4ea1\u4eba\u6570\u5747\u5360\u5168\u7403<\/span><span>50%<\/span><span>\u5de6\u53f3\uff0c\u5408\u5e76\u8109\u7ba1\u764c\u6813\u662f\u5f71\u54cd\u809d\u764c\u60a3\u8005\u9884\u540e\u7684\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\uff0c\u5c24\u5176\u662f\u5408\u5e76\u4e0b\u8154\u9759\u8109\u764c\u6813\u7684\u809d\u764c\u60a3\u8005\uff0c\u6cbb\u7597\u9009\u62e9\u76f8\u5bf9\u6709\u9650\uff0c\u603b\u4f53\u9884\u540e\u5dee\u3002\u5373\u4f7f\u7ecf\u5916\u79d1\u5207\u9664\uff0c\u672f\u540e\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e5f\u4ec5\u4e3a<\/span><span>17.8<\/span><span>\u4e2a\u6708<\/span><sup><span>[2]<\/span><\/sup><span>\uff0c\u800c\u63a5\u53d7\u5176\u4ed6\u5c40\u90e8\u6216\u5168\u8eab\u836f\u7269\u6cbb\u7597\u8005\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u5219\u4ec5\u4e3a<\/span><span>5.9~15.4<\/span><span>\u4e2a\u6708<\/span><sup><span>[2-4]<\/span><\/sup><span>\uff0c\u56e0\u6b64\u4e9f\u9700\u65b0\u7684\u6cbb\u7597\u6280\u672f\u548c\u7b56\u7565\u6539\u5584\u6b64\u7c7b\u60a3\u8005\u9884\u540e\u3002<\/span><\/p>\n<p><span>2015<\/span><span>\u5e74<\/span><span>5<\/span><span>\u6708\uff0c\u4e0a\u6d77\u4ec1\u6d4e\u533b\u9662\u80bf\u7624\u4ecb\u5165\u79d1\u8054\u5408\u79d1\u6d4e\u751f\u7269\u533b\u836f\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u5f00\u5c55\u4e86\u5168\u7403\u9996\u4e2a\u9776\u5411<\/span><span>GPC3<\/span><span>\uff08<\/span><span>Glypican-3<\/span><span>\uff09\u86cb\u767d\u7684<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08<\/span><span>HCC<\/span><span>\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08\u90e8\u5206\u6570\u636e\u53d1\u8868\u4e8e<\/span><span><span class=\"xn-person\">Clin Cancer Res<\/span>. 2020<sup>[5]<\/sup><\/span><span>\uff09\uff0c<\/span><span>2<\/span><span>\u4f8b\u665a\u671f<\/span><span>HCC<\/span><span>\u60a3\u8005\u5728\u5165\u7ec4\u65f6\u5df2\u5408\u5e76\u4e0b\u8154\u9759\u8109\u764c\u6813\uff0c\u5176\u4e2d<\/span><span>1<\/span><span>\u4f8b\u540c\u65f6\u5408\u5e76\u8179\u819c\u540e\u6dcb\u5df4\u7ed3\u8f6c\u79fb\uff0c\u9884\u671f\u6cbb\u7597\u7ed3\u5c40\u5f88\u4e0d\u4e50\u89c2\u3002\u7136\u800c\uff0c\u4ee4\u4eba\u60ca\u559c\u7684\u662f\uff0c\u6b64<\/span><span>2<\/span><span>\u4f8b\u60a3\u8005\u5728\u7ecf\u5c40\u90e8\u6cbb\u7597\u8054\u5408<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u8f93\u6ce8\u540e\u6548\u679c\u663e\u8457\uff0c\u5728\u957f\u671f\u968f\u8bbf\u671f\u95f4\u5747\u5448\u65e0\u7624\u72b6\u6001\u3002\u65e5\u524d\uff0c\u8fd9\u4e24\u4f4d\u60a3\u8005\u56de\u5230\u4ec1\u6d4e\u533b\u9662\u518d\u6b21\u5b8c\u6210\u590d\u67e5\uff0c\u7ed3\u679c\u663e\u793a\u4ecd\u7136\u65e0\u80bf\u7624\u590d\u53d1\uff0c\u4ec1\u6d4e\u533b\u9662\u7684\u7814\u7a76\u8005\u4e3a\u4e24\u4f4d\u60a3\u8005\u4e3e\u529e\u4e86\u4e00\u573a\u7b80\u77ed\u7684\u5e86\u795d\u4eea\u5f0f\u3002<\/span><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2117\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2245331\/image_5019987_17509421.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_5019987_17509421.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1418\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2245332\/image_5019987_17509468.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_5019987_17509468.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder4544\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2245333\/image_5019987_17509546.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_5019987_17509546.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><span>&nbsp;<\/span><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder6553\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2245334\/image_5019987_17509624.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_5019987_17509624.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><span>\u60a3\u8005<\/span><span>1<\/span><span>\u786e\u8bca<\/span><span>HCC<\/span><span>\u540e\u63a5\u53d7\u4e86<\/span><span>2<\/span><span>\u6b21\u4ecb\u5165\u6cbb\u7597\u548c<\/span><span>1<\/span><span>\u6b21\u5fae\u6ce2\u6d88\u878d\u6cbb\u7597\uff0c\u4f46\u6cbb\u7597\u540e\u80bf\u7624\u51fa\u73b0\u5feb\u901f\u8fdb\u5c55\u4e14\u5e76\u53d1\u4e0b\u8154\u9759\u8109\u764c\u6813\uff0c\u9488\u5bf9\u809d\u5185\u590d\u53d1\u80bf\u7624\u548c\u4e0b\u8154\u9759\u8109\u764c\u6813\u8fdb\u884c\u5c40\u90e8\u6cbb\u7597\uff08\u5fae\u6ce2\u6d88\u878d\u548c\u4f3d\u9a6c\u5200\uff09\u540e\u63a5\u53d7<\/span><span>GPC3 CAR-T<\/span><span>\u7ec6\u80de\u6cbb\u7597\uff0c\u534a\u5e74\u540e<\/span><span>AFP<\/span><span>\u964d\u81f3\u6b63\u5e38\u6c34\u5e73\uff0c\u5f71\u50cf\u5b66\u590d\u67e5\u672a\u89c1\u660e\u663e\u6d3b\u6027\u80bf\u7624\uff0c\u8fc4\u4eca\u65e0\u7624\u751f\u5b58\u5df2\u8d85\u8fc7<\/span><span>8<\/span><span>\u5e74\uff08<\/span><span>2015.07-2023.08<\/span><span>\uff09\u3002\u60a3\u8005<\/span><span>2<\/span><span>\u809d\u764c\u5207\u9664\u672f\u540e\u809d\u5185\u80bf\u7624\u590d\u53d1\uff0c\u53cd\u590d\u591a\u6b21\u8fdb\u884c<\/span><span>TACE<\/span><span>\u548c\u5fae\u6ce2\u6d88\u878d\u540e\u4f9d\u7136\u65e0\u6cd5\u6709\u6548\u63a7\u5236\u80bf\u7624\u8fdb\u5c55\uff0c\u51fa\u73b0\u591a\u53d1\u809d\u5185\u80bf\u7624\u590d\u53d1\uff08\u5927\u4e8e<\/span><span>6<\/span><span>\u679a\uff09\uff0c\u5e76\u5148\u540e\u53d1\u751f\u8179\u819c\u540e\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u548c\u4e0b\u8154\u9759\u8109\u764c\u6813\u3002\u901a\u8fc7\u5c40\u90e8\u6cbb\u7597\uff08\u5fae\u6ce2\u6d88\u878d\u548c\u4f3d\u9a6c\u5200\uff09\u63a7\u5236\u809d\u5185\u80bf\u7624\u3001\u4e0b\u8154\u9759\u8109\u764c\u6813\u53ca\u8179\u819c\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7624\uff0c\u540c\u65f6\u8054\u5408<\/span><span>GPC3 CAR-T<\/span><span>\u7ec6\u80de\u6cbb\u7597\uff0c\u76ee\u524d\u8be5\u60a3\u8005\u65e0\u7624\u751f\u5b58\u5df2\u8d85\u8fc7<\/span><span>7<\/span><span>\u5e74\uff08<\/span><span>2016.07-2023.08<\/span><span>\uff09\u3002\u6b64\u5916\uff0c\u8be5\u60a3\u8005\u5728<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u8f93\u6ce8\u671f\u95f4\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u5305\u62ec\u53d1\u70ed\u3001\u4e4f\u529b\u3001\u4e00\u8fc7\u6027\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u548c<\/span><span>1<\/span><span>\u7ea7<\/span><span>CRS<\/span><span>\u3002<\/span><\/p>\n<p><span>\u968f\u8bbf\u671f\u95f4\uff0c\u4e24\u4f8b\u60a3\u8005\u9664\u53e3\u670d\u6297\u4e59\u809d\u75c5\u6bd2\u836f\u7269\uff0c\u672a\u884c\u5176\u4ed6\u4efb\u4f55\u6297\u80bf\u7624\u6cbb\u7597\u3002<\/span><\/p>\n<p><span>\u672c\u7814\u7a76\u7275\u5934\u8005\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u4ec1\u6d4e\u533b\u9662\u80bf\u7624\u4ecb\u5165\u79d1\u4e3b\u4efb\u7fdf\u535a\u6559\u6388\u8868\u793a\uff1a\u201c\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u4e00\u76f4\u662f\u533b\u5b66\u754c\u7684\u96be\u9898\uff0c\u5c24\u5176\u662f\u5bf9\u4e8e\u4f34\u6709\u4e0b\u8154\u9759\u8109\u764c\u6813\u7684\u60a3\u8005\uff0c\u9884\u540e\u66f4\u52a0\u4e0d\u5bb9\u4e50\u89c2\u3002\u672c\u6848\u4f8b\u62a5\u9053\u4e2d\uff0c\u4e24\u4f8b\u60a3\u8005\u901a\u8fc7\u5c40\u90e8\u6cbb\u7597\u8054\u5408\u9776\u5411<\/span><span>GPC3<\/span><span>\u7684<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u6cbb\u7597\u800c\u8fbe\u5230\u957f\u671f\u65e0\u7624\u751f\u5b58\uff0c\u4e3a\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u653e\u773c\u5168\u7403\uff0c\u5c3d\u7ba1\u79d1\u5b66\u5bb6\u4eec\u5728\u5b9e\u4f53\u7624<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u503e\u6ce8\u4e86\u5927\u91cf\u5fc3\u8840\uff0c\u4f46\u662f\u53d7\u9650\u4e8e\u5b9e\u4f53\u7624\u56fa\u6709\u7684\u7269\u7406\u5c4f\u969c\u548c\u514d\u75ab\u5c4f\u969c\u3001\u80bf\u7624\u7ec6\u80de\u7684\u5f02\u8d28\u6027\u3001\u6297\u539f\u7684\u7279\u5f02\u6027\u4ee5\u53ca<\/span><span>CAR-T<\/span><span>\u6cbb\u7597\u53ef\u80fd\u5e26\u6765\u7684\u8bf8\u591a\u98ce\u9669\u7b49\u56e0\u7d20\uff0c\u5b9e\u4f53\u7624<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u6cbb\u7597\u4ecd\u7136\u4e3e\u6b65\u7ef4\u8270\u3001\u9762\u4e34\u8bf8\u591a\u56f0\u5883\u548c\u6311\u6218\u3002\u201d<\/span><\/p>\n<p><span>\u79d1\u6d4e\u836f\u4e1a\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001\u9996\u5e2d\u6267\u884c\u5b98\u3001\u9996\u5e2d\u79d1\u5b66\u5b98\u674e\u5b97\u6d77\u535a\u58eb\u8868\u793a\uff1a\u201c\u4f5c\u4e3a\u4e00\u5bb6\u4ee5\u6cbb\u6108\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e3a\u4f7f\u547d\u7684\u4f01\u4e1a\uff0c\u6211\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e<\/span><span>CAR-T<\/span><span>\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u5404\u79cd\u521b\u65b0\u5c1d\u8bd5\uff0c\u5982\u6b64\u524d\u62a5\u9053\u7684\u5168\u7403\u9996\u4e2a\u91c7\u7528\u5c0f\u5206\u5b50\u836f\u7269\u4e0e<\/span><span>GPC3 CAR-T<\/span><span>\u8054\u5408\u6cbb\u7597\u665a\u671f\u809d\u764c\u5e76\u8fbe\u5230\u6301\u7eed\u5b8c\u5168\u7f13\u89e3\u7684\u75c5\u4f8b<\/span><sup><span>[6]<\/span><\/sup><span>\u3002\u6b64\u6b21\u62a5\u9053\u7684\u4e24\u4f8b\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u5728\u63a5\u53d7\u5c40\u90e8\u6cbb\u7597\u548c\u9776\u5411<\/span><span>GPC3 CAR-T<\/span><span>\u7ec6\u80de\u8f93\u6ce8\u540e\uff0c\u5747\u5b9e\u73b0\u4e86\u4e03\u5e74\u4ee5\u4e0a\u7684\u6301\u7eed\u65e0\u75c5\u751f\u5b58\uff0c\u8bc1\u660e\u4e86<\/span><span>CAR-T<\/span><span>\u901a\u8fc7\u4e00\u4e9b\u521b\u65b0\u6027\u6cbb\u7597\u7b56\u7565\u6709\u53ef\u80fd\u6210\u4e3a\u6cbb\u6108\u5b9e\u4f53\u7624\u7684\u624b\u6bb5\u3002<\/span><span>\u201d<\/span><\/p>\n<p><b><span>\u5173\u4e8e\u79d1\u6d4e\u836f\u4e1a<\/span><\/b><\/p>\n<p><span>\u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a<\/span><span>2171.HK<\/span><span>\uff09\u662f\u4e00\u5bb6\u5728\u4e2d\u56fd\u53ca\u7f8e\u56fd\u62e5\u6709\u4e1a\u52a1\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e3b\u8981\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u7597\u6cd5\u3002\u6211\u4eec\u5efa\u7acb\u4e86\u4ece\u9776\u70b9\u53d1\u73b0\u3001\u521b\u65b0\u578b<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u7814\u5236\u3001\u4e34\u5e8a\u8bd5\u9a8c\u5230\u5546\u4e1a\u89c4\u6a21\u751f\u4ea7\u7684<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u7814\u7a76\u4e0e\u5f00\u53d1\u5e73\u53f0\u3002\u6211\u4eec\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u65b0\u6280\u672f\u4ee5\u53ca\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4ee5\u89e3\u51b3<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u7597\u6cd5\u7684\u91cd\u5927\u6311\u6218\uff0c\u6bd4\u5982\u63d0\u9ad8\u5b89\u5168\u6027\uff0c\u63d0\u9ad8\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u7597\u6548\u548c\u964d\u4f4e\u6cbb\u7597\u6210\u672c\u3002\u6211\u4eec\u7684\u4f7f\u547d\u662f\u6210\u4e3a\u80fd\u4e3a\u5168\u7403\u764c\u75c7\u60a3\u8005\u5e26\u6765\u521b\u65b0\u548c\u5dee\u5f02\u5316\u7684\u7ec6\u80de\u7597\u6cd5\uff0c\u5e76\u4f7f\u764c\u75c7\u53ef\u6cbb\u6108\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u9886\u5bfc\u8005\u3002<\/span><\/p>\n<p><b><span>\u524d\u77bb\u6027\u58f0\u660e<\/span><\/b><\/p>\n<p><span>\u672c\u65b0\u95fb\u7a3f\u4e2d\u6240\u6709\u4e0d\u5c5e\u4e8e\u5386\u53f2\u4e8b\u5b9e\u6216\u4e0e\u5f53\u524d\u4e8b\u5b9e\u6216\u5f53\u524d\u6761\u4ef6\u65e0\u5173\u7684\u9648\u8ff0\u90fd\u662f\u524d\u77bb\u6027\u9648\u8ff0\u3002\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u8868\u8fbe\u4e86\u672c\u96c6\u56e2\u622a\u81f3\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\u5bf9\u672a\u6765\u4e8b\u4ef6\u7684\u5f53\u524d\u89c2\u70b9\u3001\u9884\u6d4b\u3001\u4fe1\u5ff5\u548c\u9884\u671f\u3002\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u662f\u57fa\u4e8e\u672c\u96c6\u56e2\u65e0\u6cd5\u63a7\u5236\u7684\u4e00\u4e9b\u5047\u8bbe\u548c\u56e0\u7d20\u3002\u56e0\u6b64\uff0c\u5b83\u4eec\u53d7\u5230\u91cd\u5927\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u4e8b\u4ef6\u6216\u7ed3\u679c\u53ef\u80fd\u4e0e\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\uff0c\u672c\u65b0\u95fb\u7a3f\u4e2d\u8ba8\u8bba\u7684\u524d\u77bb\u6027\u4e8b\u4ef6\u53ef\u80fd\u4e0d\u4f1a\u53d1\u751f\u3002\u8fd9\u4e9b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u6211\u4eec\u6700\u8fd1\u7684\u5e74\u5ea6\u62a5\u544a\u548c\u4e2d\u671f\u62a5\u544a\u4ee5\u53ca\u5728\u6211\u4eec\u516c\u53f8\u7f51\u7ad9<a href=\"https:\/\/www.carsgen.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.carsgen.com<\/a><\/span><span>&nbsp;<\/span><span>\u4e0a\u53d1\u5e03\u7684\u5176\u4ed6\u516c\u544a\u548c\u62a5\u544a\u4e2d\u300c\u4e3b\u8981\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u300d\u6807\u9898\u4e0b\u7684\u8be6\u7ec6\u5185\u5bb9\u3002\u5bf9\u4e8e\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u4efb\u4f55\u9884\u6d4b\u3001\u76ee\u6807\u3001\u4f30\u8ba1\u6216\u9884\u6d4b\u7684\u5b9e\u73b0\u6216\u5408\u7406\u6027\uff0c\u6211\u4eec\u4e0d\u4f5c\u4efb\u4f55\u9648\u8ff0\u6216\u4fdd\u8bc1\uff0c\u4e5f\u4e0d\u5e94\u4f9d\u8d56\u8fd9\u4e9b\u9884\u6d4b\u3002<\/span><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u53c2\u8003\u6587\u732e<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">1. Shi Y, et. al. <i>Cancer Commun (Lond)<\/i>. 2023 Jul 21.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2. Kokudo T, et. al. Hepatology. 2017 Aug;66(2):510-517.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">3. Lou J, et. al. BMC Cancer. 2019 Jul 5;19(1):668.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">4. Rim CH, et. al. Int J Radiat Biol. 2020 Jun;96(6):759-766.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">5. Shi DH, et al. Clin Cancer Res. 2020 ;26(15):3979-3989.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">6. Sun H, et. al. Front Immunol. 2022 Aug 17;13:963031.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p><b><span>\u8054\u7cfb\u79d1\u6d4e\u836f\u4e1a<br \/><\/span><\/b><span>\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<\/span><a href=\"https:\/\/www.carsgen.com\/\" target=\"_blank\" rel=\"nofollow noopener\"><span>https:\/\/www.carsgen.com\/<\/span><\/a><br \/><span>\u516c\u5171\u5173\u7cfb\uff1a<a href=\"mailto:PR@carsgen.com\" target=\"_blank\" rel=\"nofollow noopener\">PR@carsgen.com<\/a><\/span><span>&nbsp;<br \/><\/span><span>\u6295\u8d44\u8005\u5173\u7cfb\uff1a<a href=\"mailto:IR@carsgen.com\" target=\"_blank\" rel=\"nofollow noopener\">IR@carsgen.com<\/a><\/span><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772023\u5e7410\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\uff0c\u4e00\u5bb6\u4e3b\u8981\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u516c\u53f8\uff0c\u5ba3\u5e03\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u9776\u5411GPC3\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u4e24\u4f8b\u957f\u671f\u65e0\u75c5\u751f\u5b58\u6848\u4f8b\u5df2\u5728\u300aCancer Communications\u300b\u6742\u5fd7\u53d1\u8868\u5e76\u88ab\u5f55\u7528\u4e3a\u5f53\u671f\u5c01\u9762\u8bba\u6587\uff0c\u9898\u4e3a\u201cCombined local therapy and CAR-GPC3 T-cell therapy in advanced hepatocellular carcinoma: a proof-of-concept treatment strategy\u201d\u3002\uff08https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cac2.12472\uff09[1]\u3002 \u809d\u764c\u662f\u6211\u56fd\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u53d1\u75c5\u548c\u6b7b\u4ea1\u4eba\u6570\u5747\u5360\u5168\u740350%\u5de6\u53f3\uff0c\u5408\u5e76\u8109\u7ba1\u764c\u6813\u662f\u5f71\u54cd\u809d\u764c\u60a3\u8005\u9884\u540e\u7684\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\uff0c\u5c24\u5176\u662f\u5408\u5e76\u4e0b\u8154\u9759\u8109\u764c\u6813\u7684\u809d\u764c\u60a3\u8005\uff0c\u6cbb\u7597\u9009\u62e9\u76f8\u5bf9\u6709\u9650\uff0c\u603b\u4f53\u9884\u540e\u5dee\u3002\u5373\u4f7f\u7ecf\u5916\u79d1\u5207\u9664\uff0c\u672f\u540e\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e5f\u4ec5\u4e3a17.8\u4e2a\u6708[2]\uff0c\u800c\u63a5\u53d7\u5176\u4ed6\u5c40\u90e8\u6216\u5168\u8eab\u836f\u7269\u6cbb\u7597\u8005\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u5219\u4ec5\u4e3a5.9~15.4\u4e2a\u6708[2-4]\uff0c\u56e0\u6b64\u4e9f\u9700\u65b0\u7684\u6cbb\u7597\u6280\u672f\u548c\u7b56\u7565\u6539\u5584\u6b64\u7c7b\u60a3\u8005\u9884\u540e\u3002 2015\u5e745\u6708\uff0c\u4e0a\u6d77\u4ec1\u6d4e\u533b\u9662\u80bf\u7624\u4ecb\u5165\u79d1\u8054\u5408\u79d1\u6d4e\u751f\u7269\u533b\u836f\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u5f00\u5c55\u4e86\u5168\u7403\u9996\u4e2a\u9776\u5411GPC3\uff08Glypican-3\uff09\u86cb\u767d\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08\u90e8\u5206\u6570\u636e\u53d1\u8868\u4e8eClin Cancer Res. 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\u53c2\u8003\u6587\u732e 1. Shi Y, et. al. Cancer Commun (Lond). 2023 Jul 21. 2. Kokudo T, et.&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2023101213390097090\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":97097,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-97090","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/97090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=97090"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/97090\/revisions"}],"predecessor-version":[{"id":97096,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/97090\/revisions\/97096"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/97097"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=97090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=97090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=97090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}