{"id":95163,"date":"2023-09-14T10:23:00","date_gmt":"2023-09-14T03:23:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023091410230095163"},"modified":"2023-09-15T04:35:27","modified_gmt":"2023-09-14T20:35:27","slug":"%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0mdm2-p53%e6%8b%ae%e6%8a%97%e5%89%82brightline-2%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e5%9c%a8%e5%8d%8e%e8%8e%b7%e6%89%b9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023091410230095163","title":{"rendered":"\u52c3\u6797\u683c\u6bb7\u683c\u7ff0MDM2-p53\u62ee\u6297\u5242Brightline-2\u4e34\u5e8a\u8bd5\u9a8c\u5728\u534e\u83b7\u6279"},"content":{"rendered":"<p class=\"prntac\"><span id=\"spanHghlt4584\">brigimadlin<\/span>\uff08BI 907828\uff09\u6709\u671b\u4e3aMDM2\u6269\u589eTP53\u91ce\u751f\u578b\u7684\u80c6\u9053\u817a\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9<\/p>\n<ul type=\"disc\">\n<li><span id=\"spanHghlt7781\">MDM2-p53<\/span>\u62ee\u6297\u5242brigimadlin\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027MDM2\u6269\u589e\uff0cTP53\u91ce\u751f\u578b\u5b9e\u4f53\u7624\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE,NMPA\uff09\u6279\u51c6<\/li>\n<li>MDM2-p53\u62ee\u6297\u5242brigimadlin\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5c24\u5176\u5728\u80c6\u9053\u764c\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4f18\u5f02\u7684\u4e34\u5e8a\u7597\u6548<\/li>\n<li>MDM2-p53\u62ee\u6297\u5242brigimadlin\u6709\u671b\u4e3aMDM2\u6269\u589e\uff0cTP53\u91ce\u751f\u578b\u7684\u80c6\u9053\u817a\u764c\u7b49\u80bf\u7624\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u5f00\u542f\u9776\u5411MDM2-p53\u8f74\u7684\u201c\u6cdb\u7624\u79cd\u201d\u6cbb\u7597\u51b3\u7b56<\/li>\n<\/ul>\n<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e749\u670814\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 2023\u5e749\u670813\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u65d7\u4e0bMDM2-p53\u62ee\u6297\u5242brigimadlin\uff08BI 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class=\"prntac\"><b>\u76f4\u9762\u80c6\u9053\u764c\u6cbb\u7597\u56f0\u5883\uff0c<\/b><b>brigimadlin\u5f00\u53d1\u5168\u65b0\u6cbb\u7597\u7b56\u7565<\/b><\/p>\n<p>\u80c6\u9053\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff08BTC\uff09\u662f\u4e00\u7c7b\u8d77\u6e90\u4e8e\u80c6\u9053\u4e0a\u76ae\u7ec6\u80de\u3001\u6076\u6027\u7a0b\u5ea6\u6781\u9ad8\u7684\u80bf\u7624\u6027\u75be\u75c5\uff1bBTC\u53d1\u75c5\u7387\u8f83\u4f4e\uff0c\u7ea6\u5360\u6d88\u5316\u9053\u6076\u6027\u80bf\u7624\u76843%\uff0c\u662f\u4ec5\u6b21\u4e8e\u809d\u7ec6\u80de\u764c\u7684\u7b2c\u4e8c\u5927\u809d\u80c6\u6076\u6027\u80bf\u7624<sup>[1]<\/sup>\u3002\u7edd\u5927\u591a\u6570BTC\u60a3\u8005\u5728\u660e\u786e\u8bca\u65ad\u65f6\u5df2\u8fdb\u5165\u665a\u671f\u9636\u6bb5\u800c\u65e0\u6cd5\u8fdb\u884c\u624b\u672f\u5e72\u9884\uff0c\u672a\u7ecf\u6cbb\u7597\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e3a3\uff5e6\u4e2a\u6708\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4e3a5%\uff5e10%<sup>[2]<\/sup>\u3002\u76ee\u524d\uff0c\u591a\u79cd\u6cbb\u7597\u624b\u6bb5\u88ab\u8fd0\u7528\u4e8e\u665a\u671fBTC\u60a3\u8005\u7684\u7cfb\u7edf\u6cbb\u7597\u4e2d\uff0c\u4f46\u7597\u6548\u5927\u591a\u6b20\u4f73\uff0c\u5373\u4fbf\u662f\u91c7\u7528\u5409\u897f\u4ed6\u6ee8\u3001\u987a\u94c2\u7b49\u4e00\u7ebf\u6807\u51c6\u7528\u836f\u7684\u665a\u671fBTC\u60a3\u8005\u4e2d\u4f4dOS\u4ecd\u4e0d\u8db310\u4e2a\u6708<sup>[3]<\/sup>\u3002\u867d\u7136\u968f\u7740\u514d\u75ab\u6cbb\u7597\u7684\u8fdb\u5c55\uff0c\u665a\u671fBTC\u7684\u751f\u5b58\u56f0\u5883\u6709\u6240\u6539\u5584\uff0cTOPAZ-1\u7b49\u7814\u7a76\u663e\u793a\u514d\u75ab\u6cbb\u7597\u8054\u5408\u5316\u7597\u80fd\u591f\u6539\u5584BTC\u60a3\u8005\u7684\u603b\u751f\u5b58\uff08OS\uff09\uff0c\u4f46\u603b\u4f53\u800c\u8a00\uff0c\u5176\u751f\u5b58\u83b7\u76ca\u4ecd\u7136\u5341\u5206\u6709\u9650<sup>[4]<\/sup>\uff0c\u6240\u4ee5\u63a2\u7d22\u65b0\u7684\u66f4\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\u5bf9BTC\u7684\u6cbb\u7597\u4ecd\u5341\u5206\u91cd\u8981\u3002<\/p>\n<p>\u968f\u7740\u7cbe\u51c6\u533b\u5b66\u65f6\u4ee3\u7684\u5230\u6765\u4ee5\u53ca\u4ece\u5206\u5b50\u5c42\u9762\u5bf9BTC\u7684\u6df1\u5165\u8ba4\u8bc6\uff0c\u9488\u5bf9\u4e0d\u540c\u4eba\u7fa4\u3001\u4e0d\u540c\u4e9a\u578b\u7684BTC\u60a3\u8005\u9009\u62e9\u7279\u5f02\u6027\u6cbb\u7597\u65b9\u6848\u662f\u672a\u6765\u6cbb\u7597\u65b9\u6cd5\u7684\u5173\u952e\u6240\u5728\u3002\u7ea65%\uff5e8%\u7684BTC\u60a3\u8005\u4e2d\u5b58\u5728MDM2\u6269\u589e\u4e14TP53\u91ce\u751f\u578b\u3002MDM2\u7684\u6269\u589e\u53ef\u80fd\u9a71\u52a8\u80bf\u7624\u53d1\u751f\uff0c\u5e76\u4e14\u5b9e\u9645\u4e0a\uff0c\u4e34\u5e8a\u524d\u4ee5\u53ca\u65b0\u751f\u6210\u7684\u4e34\u5e8a\u6570\u636e\u8868\u660e\u963b\u65adTP53\u91ce\u751f\u578b\u80bf\u7624\u4e2d\u7684MDM2\u53ef\u80fd\u662f\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u3002\u9664\u4e86BTC\u4ee5\u5916\uff0cMDM2\u6269\u589e\u8fd8\u53d1\u751f\u5728\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u3001\u80ba\u817a\u764c\u3001\u8180\u80f1\u5c3f\u8def\u4e0a\u76ae\u764c\u7b49\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\uff0c\u56e0\u6b64brigimadlin\u6216\u80fd\u591f\u6210\u4e3a\u7531MDM2-p53\u8f74\u7a81\u53d8\u9a71\u52a8\u7684\u764c\u75c7\u60a3\u8005\u7684\u6cdb\u7624\u79cd\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<p 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src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_976206_8266112.jpg\" title=\"BI 907828\u7684\u4f5c\u7528\u673a\u5236\" alt=\"BI 907828\u7684\u4f5c\u7528\u673a\u5236\" \/><\/a><br \/><span>BI 907828\u7684\u4f5c\u7528\u673a\u5236<\/span><\/p>\n<\/p><\/div>\n<p>\u6b64\u524d\u4e24\u4e2aI\u671f\u7814\u7a76\uff081403-0001,1403-0002\uff09\u63a2\u7d22\u4e86brigimadlin&plusmn;ezabenlimab\uff08BI-754091\uff0cPD-1\u6291\u5236\u5242\uff09\u7684\u521d\u6b65\u7597\u6548\uff0cbrigimadlin\u5728\u9009\u5b9a\u7684TP53\u91ce\u751f\u578b\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u4e2d\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5176\u4e2d6\u4f8b\u665a\u671fBTC\u60a3\u8005\u63a5\u53d7brigimadlin\u5355\u836f\u6cbb\u7597\uff081403-0001\uff09\uff0c4\u4f8bBTC\u60a3\u8005\u63a5\u53d7ezabenlimab\uff08BI-754091\uff09\uff0cPD-1\u6291\u5236\u5242\uff09\u8054\u5408\u6cbb\u7597\uff081403-0002\uff09\uff0c2\/6\u4f8b\u60a3\u8005\uff081403-0001\uff09\u548c3\/4\u4f8b\u60a3\u8005\uff081403-0002\uff09\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff0c2\/6\u4f8b\u60a3\u8005\uff081403-0001\uff09\u548c1\/4\u4f8b\u60a3\u8005\uff081403-0002\uff09\u8fbe\u5230\u75be\u75c5\u7a33\u5b9a\uff08\u6700\u4f73\u7f13\u89e3\uff09<sup>[5]<\/sup>\u3002<\/p>\n<p>\u968f\u7740\u6b64\u6b21Brightline-2\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6b63\u5f0f\u6279\u51c6\uff0cbrigimadlin\u5728\u5305\u62ecBTC\u5728\u5185\u7684\u591a\u79cd\u5b9e\u4f53\u7624\u6cbb\u7597\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c06\u5f97\u5230\u8fdb\u4e00\u6b65\u9a8c\u8bc1\uff0cbrigimadlin\u6216\u80fd\u6210\u4e3aMDM2-p53\u8f74\u7a81\u53d8\u9a71\u52a8\u7684\u764c\u75c7\u60a3\u8005\u7684\u4e00\u79cd\u53ef\u884c\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4e3a\u8fd9\u90e8\u5206\u4eba\u7fa4\u63d0\u4f9b\u66f4\u591a\u7684\u6cbb\u7597\u673a\u4f1a\u3002\u4e0e\u6b64\u540c\u65f6\uff0cbrigimadlin\u4e00\u7ebf\u6cbb\u7597\u53bb\u5206\u5316\u8102\u80aa\u8089\u7624\uff08DDLPS\uff09\u2161\/\u2162\u671f\u5168\u7403\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8cBrightline-1\u8bd5\u9a8c\u6b63\u5728\u79ef\u6781\u5f00\u5c55\u4e2d\uff0c\u6709\u671b\u4e3a\u8fd9\u90e8\u5206\u96be\u6cbb\u3001\u7f55\u89c1\u7624\u79cd\u60a3\u8005\u5e26\u6765\u5168\u65b0\u5e0c\u671b\u3002<\/p>\n<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5927\u4e2d\u534e\u533a\u7814\u53d1\u548c\u533b\u5b66\u90e8\u9ad8\u7ea7\u526f\u603b\u88c1\u5f20\u7ef4\u535a\u58eb\u8868\u793a\uff1a\u201cMDM2-p53\u62ee\u6297\u5242brigimadlin\u662f\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5728\u80bf\u7624\u9886\u57df\u91cd\u70b9\u5e03\u5c40\u7684\u5728\u7814\u4ea7\u54c1\u4e4b\u4e00, 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Key\uff09\u2019\u9879\u76ee\uff0c\u4e0e\u5168\u7403\u2018\u96f6\u65f6\u5dee\u2019\u5f00\u5c55\u7814\u53d1\u8ba1\u5212\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u4e0d\u65ad\u4f18\u5316\u80bf\u7624\u6cbb\u7597\u65b9\u5f0f\uff0c\u52aa\u529b\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\uff0c\u4e3a\u4e2d\u56fd\u4ee5\u53ca\u5168\u7403\u80bf\u7624\u60a3\u8005\u63d0\u4f9b\u66f4\u5b89\u5168\u3001\u9ad8\u6548\u3001\u548c\u7cbe\u51c6\u7684\u521b\u65b0\u7597\u6cd5\u3002\u201c<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u3010\u53c2\u8003\u6587\u732e\u3011\uff1a<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] \u6731\u884c\u4f0d,\u90b1\u9ea6\u8f69,\u674e\u9759.\u665a\u671f\u80c6\u9053\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\u8fdb\u5c55[J].\u4e34\u5e8a\u5916\u79d1\u6742\u5fd7,2022,30(11):1098-1100.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]\u7504\u81ea\u529b,\u6c88\u54f2\u6c11,\u5b59\u57f9\u9f99.\u80c6\u9053\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u5c55\u671b[J].\u4e2d\u56fd\u514d\u75ab\u5b66\u6742\u5fd7,2021,37(22):2766-2770.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]\u7f57\u594e,\u5b59\u822a,\u5434\u4f20\u65b0.\u80c6\u9053\u764c\u514d\u75ab\u7597\u6cd5\u7684\u73b0\u72b6\u53ca\u5c55\u671b[J].\u4e34\u5e8a\u809d\u80c6\u75c5\u6742\u5fd7,2019,35(12):2837-2840.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[4]Oh et al. NEJM Evid 2022; <a href=\"https:\/\/doi.org\/10.1056\/EVIDoa2200015\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1056\/EVIDoa2200015<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[5]Goyal L, Harding J J, Ueno M, et al. A phase IIa\/IIb, open-label trial of BI 907828, an MDM2\u2013p53 antagonist, in patients with locally advanced\/metastatic biliary tract carcinoma or pancreatic ductal adenocarcinoma: Brightline-2[J]. Journal of Clinical Oncology 41, no. 16_suppl (June 01, 2023) TPS4179-TPS4179.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>brigimadlin\uff08BI 907828\uff09\u6709\u671b\u4e3aMDM2\u6269\u589eTP53\u91ce\u751f\u578b\u7684\u80c6\u9053\u817a\u764c\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9 MDM2-p53\u62ee\u6297\u5242brigimadlin\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027MDM2\u6269\u589e\uff0cTP53\u91ce\u751f\u578b\u5b9e\u4f53\u7624\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE,NMPA\uff09\u6279\u51c6 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Key\uff09\u2019\u9879\u76ee\uff0c\u4e0e\u5168\u7403\u2018\u96f6\u65f6\u5dee\u2019\u5f00\u5c55\u7814\u53d1\u8ba1\u5212\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u4e0d\u65ad\u4f18\u5316\u80bf\u7624\u6cbb\u7597\u65b9\u5f0f\uff0c\u52aa\u529b\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\uff0c\u4e3a\u4e2d\u56fd\u4ee5\u53ca\u5168\u7403\u80bf\u7624\u60a3\u8005\u63d0\u4f9b\u66f4\u5b89\u5168\u3001\u9ad8\u6548\u3001\u548c\u7cbe\u51c6\u7684\u521b\u65b0\u7597\u6cd5\u3002\u201c \u3010\u53c2\u8003\u6587\u732e\u3011\uff1a [1] \u6731\u884c\u4f0d,\u90b1\u9ea6\u8f69,\u674e\u9759.\u665a\u671f\u80c6\u9053\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\u8fdb\u5c55[J].\u4e34\u5e8a\u5916\u79d1\u6742\u5fd7,2022,30(11):1098-1100. [2]\u7504\u81ea\u529b,\u6c88\u54f2\u6c11,\u5b59\u57f9\u9f99.\u80c6\u9053\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u5c55\u671b[J].\u4e2d\u56fd\u514d\u75ab\u5b66\u6742\u5fd7,2021,37(22):2766-2770. [3]\u7f57\u594e,\u5b59\u822a,\u5434\u4f20\u65b0.\u80c6\u9053\u764c\u514d\u75ab\u7597\u6cd5\u7684\u73b0\u72b6\u53ca\u5c55\u671b[J].\u4e34\u5e8a\u809d\u80c6\u75c5\u6742\u5fd7,2019,35(12):2837-2840. [4]Oh et al. NEJM Evid 2022; https:\/\/doi.org\/10.1056\/EVIDoa2200015 [5]Goyal L, Harding J J, Ueno M, et al. 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