{"id":93665,"date":"2023-09-01T17:30:00","date_gmt":"2023-09-01T10:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023090117300093665"},"modified":"2023-09-02T23:19:44","modified_gmt":"2023-09-02T15:19:44","slug":"%e9%98%bf%e6%96%af%e5%88%a9%e5%ba%b7%e7%a5%9e%e7%bb%8f%e7%ba%a4%e7%bb%b4%e7%98%a4%e7%97%85%e6%b2%bb%e7%96%97%e8%8d%af%e7%89%a9%e7%a7%91%e8%b5%9b%e4%bc%98%e5%9c%a8%e4%b8%ad%e5%9b%bd%e4%b8%8a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023090117300093665","title":{"rendered":"\u963f\u65af\u5229\u5eb7\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u6cbb\u7597\u836f\u7269\u79d1\u8d5b\u4f18\u00ae\u5728\u4e2d\u56fd\u4e0a\u5e02"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e749\u67081\u65e5<\/span> <span>\/\u7f8e\u901a\u793e\/ &#8212; \u4eca\u65e5\uff0c\u963f\u65af\u5229\u5eb7\u5728\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u9886\u57df\u9996\u4e2a\u521b\u65b0\u836f\u7269\u79d1\u8d5b\u4f18<\/span><sup><span>&reg;<\/span><\/sup><span>\uff08\u82f1\u6587\u5546\u54c1\u540d\uff1a<\/span><span>Koselugo\uff0c\u901a\u7528\u540d\uff1a\u786b\u9178\u6c22\u53f8\u7f8e\u66ff\u5c3c\u80f6\u56ca\uff09\u6b63\u5f0f\u4e0a\u5e02\uff0c\u60e0\u53ca3\u5c81\u53ca3\u5c81\u4ee5\u4e0a\u4f34\u6709\u75c7\u72b6\u3001\u65e0\u6cd5\u624b\u672f\u7684\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624\uff08PN\uff09\u7684I\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\uff08NF1\uff09\u513f\u7ae5\u60a3\u8005\u3002<\/span><\/p>\n<p><span>\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\uff08<\/span><span>NF\uff09\u662f\u4e00\u7c7b\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u6027\u75be\u75c5\uff0c\u5728\u5176\u4e09\u79cd\u4e3b\u8981\u5206\u578b\u4e2dNF1\u7ea6\u536098%<sup>[1]<\/sup>\u3002\u4e2d\u56fd\u6682\u65e0NF1\u6d41\u884c\u75c5\u5b66\u6570\u636e\uff0c\u63a8\u7b97\u53d1\u75c5\u7387\u4e3a5\/1,000,000<sup>[2]<\/sup>\u3002\u5176\u4e2d\uff0c\u7ea6\u670930%-50%\u7684NF1\u60a3\u8005\u4f1a\u51fa\u73b0\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624\uff08NF1-PN\uff09<sup>[3-5]<\/sup>\u3002\u4f5c\u4e3a\u7d2f\u53ca\u5168\u8eab\u591a\u7cfb\u7edf\u7684\u6162\u6027\u7efc\u5408\u5f81\uff0cNF1-PN\u4f1a\u9020\u6210\u6bc1\u5bb9\u3001\u75bc\u75db\u3001\u529f\u80fd\u969c\u788d\u3001\u7ec8\u751f\u8ba4\u77e5\u969c\u788d\u7b49<sup>[6-10]<\/sup>\uff0c\u60a3\u513f\u8f83\u4e00\u822c\u4eba\u7fa4\u5f15\u53d1\u6076\u6027\u80bf\u7624\u53ca\u5fc3\u810f\u75be\u75c5\u98ce\u9669\u9ad8\u8fbe13%\uff0c\u751f\u5b58\u5e74\u9650\u5e73\u5747\u51cf\u5c1115\u5e74<sup>[11-14]<\/sup>\u3002<\/span><\/p>\n<p><span>\u5728\u53f8\u7f8e\u66ff\u5c3c\u51fa\u73b0\u524d\uff0c<\/span><span>NF1\u4e3b\u8981\u7684\u6cbb\u7597\u65b9\u6848\u5305\u62ec\u624b\u672f\u5207\u9664\u3001\u5916\u79d1\u6574\u5f62\u7b49<sup>[15]<\/sup>\uff0c\u4f4690% \u7684NF1-PN\u65e0\u6cd5\u901a\u8fc7\u624b\u672f\u6cbb\u7597\u6216\u5b8c\u5168\u5207\u9664\uff0c\u4e14\u590d\u53d1\u7387\u9ad8<sup>[1]<\/sup>\u3002<\/span><\/p>\n<p><b><span>\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e5d\u4eba\u6c11\u533b\u9662\u526f\u9662\u957f\u3001\u6574\u590d\u5916\u79d1\u4e3b\u4efb\u674e\u9752\u5cf0<\/span><\/b><span>\u8868\u793a\uff1a\u201c<\/span><span>I\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u7d2f\u53ca\u5168\u8eab\u591a\u7cfb\u7edf\uff0c\u53ef\u5bfc\u81f4\u75bc\u75db\u3001\u6b8b\u75be\u3001\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u53ca\u6076\u53d8\u3002\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u80fd\u591f\u770b\u5230\u53f8\u7f8e\u66ff\u5c3c\u6b63\u5f0f\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u4f5c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u7684NF1\u9886\u57df\u6cbb\u7597\u836f\u7269\uff0c\u53f8\u7f8e\u66ff\u5c3c\u6709\u671b\u5e2e\u52a9\u66f4\u591a\u60a3\u513f\u8fce\u6765\u66f4\u597d\u7684\u751f\u6d3b\u3002\u201d<\/span><\/p>\n<p><b><span>\u6df1\u5733\u5e02\u6ce1\u6ce1\u5bb6\u56ed\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u5173\u7231\u4e2d\u5fc3\u8d1f\u8d23\u4eba\u738b\u82b3<\/span><\/b><span>\u8868\u793a\uff1a<\/span><span>\u201c\u4f5c\u4e3a\u4e00\u79cd\u7f55\u89c1\u7684\u3001\u8fdb\u884c\u6027\u7684\u9057\u4f20\u6027\u75be\u75c5\uff0cNF1\u56e0\u53cd\u590d\u53d1\u4f5c\u53ca\u4e25\u91cd\u7684\u5e76\u53d1\u75c7\u7ed9\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e26\u6765\u4e86\u6c89\u91cd\u7684\u8eab\u5fc3\u8d1f\u62c5\u3002\u671f\u5f85\u5728\u521b\u65b0\u836f\u7269\u7684\u5e2e\u52a9\u4e0b\uff0cNF1\u60a3\u8005\u53ef\u4ee5\u63a7\u5236\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e0e\u5176\u7167\u62a4\u8005\u5c3d\u65e9\u56de\u5f52\u6b63\u5e38\u751f\u6d3b\u3002\u201d<\/span><\/p>\n<p><b><span>\u963f\u65af\u5229\u5eb7\u5168\u7403\u6267\u884c\u526f\u603b\u88c1\uff0c\u56fd\u9645\u4e1a\u52a1\u53ca\u4e2d\u56fd\u603b\u88c1\u738b\u78ca<\/span><\/b><span>\u8868\u793a\uff1a<\/span><span>\u201c\u6211\u4eec\u6df1\u523b\u6d1e\u6089\u5e76\u7406\u89e3\u4e2d\u56fdNF1\u60a3\u8005\u53ca\u7f55\u89c1\u75c5\u7fa4\u4f53\u6240\u9762\u4e34\u7684\u56f0\u5883\uff0c\u4e5f\u975e\u5e38\u81ea\u8c6a\u80fd\u4e3a\u4e2d\u56fd NF1 \u60a3\u513f\u5e26\u6765\u9996\u4e2a\u836f\u7269\u6cbb\u7597\u65b9\u6848\uff0c\u5e2e\u52a9\u60a3\u8005\u5b9e\u73b0\u6709\u5e0c\u671b\u3001\u9ad8\u8d28\u91cf\u53ca\u6709\u5c0a\u4e25\u7684\u751f\u6d3b\u3002\u963f\u65af\u5229\u5eb7\u51ed\u501f\u9886\u5148\u7684\u79d1\u5b66\u521b\u65b0\u5b9e\u529b\u548c\u5728\u7f55\u89c1\u75c5\u9886\u57df\u7684\u524d\u77bb\u6027\u5e03\u5c40\uff0c\u5c06\u6301\u7eed\u52a0\u901f\u5f15\u5165\u7f55\u89c1\u75c5\u521b\u65b0\u836f\u54c1\uff0c\u534f\u540c\u5404\u65b9\u5408\u4f5c\u4f19\u4f34\u63a8\u52a8\u836f\u7269\u53ef\u53ca\uff0c\u652f\u6301\u5efa\u8bbe\u5065\u5168\u7f55\u89c1\u75c5\u8bca\u7597\u751f\u6001\u4f53\u7cfb\uff0c\u9020\u798f\u4e2d\u56fd\u7f55\u89c1\u75c5\u60a3\u8005\u3002\u201d<\/span><\/p>\n<p><span>\u622a\u81f3\u76ee\u524d\uff0c\u53f8\u7f8e\u66ff\u5c3c\u5df2\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u65e5\u672c\u7b49\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u4f34\u6709\u75c7\u72b6\u3001\u65e0\u6cd5\u624b\u672f\u7684\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624\u7684<\/span><span>I\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u513f\u7ae5\u60a3\u8005\u3002<\/span><\/p>\n<p><b><u><span>\u5173\u4e8e<\/span><\/u><\/b><b><u><span>I\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\uff08NF1\uff09<\/span><\/u><\/b><\/p>\n<p><span>NF1\u662f\u7531NF1\u57fa\u56e0\u6216\u9057\u4f20\u7a81\u53d8\u5f15\u8d77\u7d2f\u53ca\u591a\u7cfb\u7edf\u7684\u9057\u4f20\u6027\u75be\u75c5<sup>[12]<\/sup>\uff0c\u4f34\u968f\u591a\u79cd\u75c7\u72b6\uff0c\u5305\u62ec\u5728\u76ae\u80a4\u5916\u4fa7\u6216\u5185\u90e8\u5f62\u6210\u795e\u7ecf\u7ea4\u7ef4\u7624\u548c\u8272\u7d20\u6c89\u7740\uff08\u725b\u5976\u5496\u5561\u6591\uff09\u7b49\u3002\u5176\u4e2d\uff0c30-50%\u7684NF1\u60a3\u8005\u4f1a\u4f34\u53d1\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624<sup>[11, 12]<\/sup>\u3002\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624\uff08PN\uff09\u53ef\u5f15\u8d77\u6bc1\u5bb9\u3001\u75bc\u75db\u3001\u8fd0\u52a8\u53ca\u547c\u5438\u529f\u80fd\u969c\u788d\u3001\u89c6\u529b\u53d7\u635f\u4ee5\u53ca\u8180\u80f1\u6216\u80a0\u9053\u529f\u80fd\u969c\u788d\u7b49<sup>[2,11,13,16,17]<\/sup>\u3002\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624\u591a\u53d1\u751f\u4e8e\u513f\u7ae5\u65e9\u671f\uff0c\u4e25\u91cd\u7a0b\u5ea6\u5404\u4e0d\u76f8\u540c\uff0c\u9884\u671f\u5bff\u547d\u53ef\u80fd\u4f1a\u51cf\u5c1115\u5e74<sup>[11-14]<\/sup>\u3002<\/span><\/p>\n<p><b><u><span>\u5173\u4e8e\u53f8\u7f8e\u66ff\u5c3c<\/span><\/u><\/b><\/p>\n<p><span>\u53f8\u7f8e\u66ff\u5c3c\u662f\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u7528\u4e8e\u6cbb\u7597<\/span><span>3\u5c81\u53ca3\u5c81\u4ee5\u4e0a\u4f34\u6709\u75c7\u72b6\u3001\u65e0\u6cd5\u624b\u672f\u7684\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624\uff08PN\uff09\u7684I\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\uff08NF1\uff09\u513f\u7ae5\u60a3\u8005\u7684\u836f\u7269\u7597\u6cd5<sup>18<\/sup>\uff0c\u53ef\u963b\u65ad\u53c2\u4e0e\u4fc3\u8fdb\u7ec6\u80de\u751f\u957f\u7684\u7279\u5b9a\u9176\uff08MEK1\u548cMEK2\uff09<sup>[18]<\/sup>\u3002\u5728NF1\u4e2d\uff0c\u8fd9\u4e9b\u9176\u8fc7\u5ea6\u6d3b\u8dc3\uff0c\u5bfc\u81f4\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624\u4ee5\u4e0d\u53d7\u63a7\u5236\u7684\u65b9\u5f0f\u751f\u957f\u3002\u901a\u8fc7\u963b\u65ad\u7279\u5b9a\u9176\uff0c\u53f8\u7f8e\u66ff\u5c3c\u53ef\u51cf\u7f13\u75c5\u60c5<sup>18<\/sup>\u3002\u53f8\u7f8e\u66ff\u5c3c\u5df2\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u65e5\u672c\u3001\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\uff0c\u5e76\u5728\u5168\u4e16\u754c\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u88ab\u8ba4\u5b9a\u4e3a\u201c\u5b64\u513f\u836f\u201d\u3002<\/span><\/p>\n<p><b><u><span>\u5173\u4e8e\u963f\u65af\u5229\u5eb7<\/span><\/u><\/b><\/p>\n<p><span>\u963f\u65af\u5229\u5eb7\uff08<\/span><span>LSE\/STO\/<\/span><span>Nasdaq: AZN<\/span><span>\uff09\u662f\u4e00\u5bb6\u79d1\u5b66\u81f3\u4e0a\u7684\u5168\u7403\u6027\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u53ca\u8425\u9500\u5904\u65b9\u7c7b\u836f\u54c1\uff0c\u91cd\u70b9\u5173\u6ce8\u80bf\u7624\u3001\u5305\u62ec\u5fc3\u8840\u7ba1\u80be\u810f\u53ca\u4ee3\u8c22\u3001\u547c\u5438\u53ca\u514d\u75ab\u3001\u75ab\u82d7\u53ca\u611f\u67d3\u5728\u5185\u7684\u751f\u7269\u5236\u836f\u4ee5\u53ca\u7f55\u89c1\u75c5\u7b49\u9886\u57df\u3002\u963f\u65af\u5229\u5eb7\u5168\u7403\u603b\u90e8\u4f4d\u4e8e\u82f1\u56fd\u5251\u6865\uff0c\u4e1a\u52a1\u904d\u5e03\u4e16\u754c<\/span><span>100<\/span><span>\u591a\u4e2a\u56fd\u5bb6\uff0c\u521b\u65b0\u836f\u7269\u60e0\u53ca\u5168\u7403\u6570\u767e\u4e07\u60a3\u8005\u3002\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<\/span><a href=\"http:\/\/www.astrazeneca.com\/\" target=\"_blank\" rel=\"nofollow noopener\"><span>www.astrazeneca.com<\/span><\/a><span>\u3002<\/span><\/p>\n<p><b><u><span>\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u4e2d\u56fd<\/span><\/u><\/b><\/p>\n<p><span>\u963f\u65af\u5229\u5eb7\u81ea<\/span><span> 1993 \u5e74\u8fdb\u5165\u4e2d\u56fd\u4ee5\u6765\uff0c\u4e13\u6ce8\u4e2d\u56fd\u60a3\u8005\u9700\u6c42\u6700\u8feb\u5207\u7684\u6cbb\u7597\u9886\u57df\uff0c\u5305\u62ec\u80bf\u7624\u3001\u5fc3\u8840\u7ba1\u3001\u80be\u810f\u3001\u4ee3\u8c22\u3001\u547c\u5438\u3001\u6d88\u5316\u3001\u7f55\u89c1\u75c5\u3001\u75ab\u82d7\u6297\u4f53\u53ca\u81ea\u4f53\u514d\u75ab\u7b49\uff0c\u5df2\u5c06\u8fd1 40 \u79cd\u521b\u65b0\u836f\u7269\u5e26\u5230\u4e2d\u56fd\u3002\u963f\u65af\u5229\u5eb7\u4e2d\u56fd\u603b\u90e8\u53ca\u5168\u7403\u7814\u53d1\u4e2d\u56fd\u4e2d\u5fc3\u4f4d\u4e8e\u4e0a\u6d77\uff0c\u5e76\u5728\u65e0\u9521\u3001\u6cf0\u5dde\u3001\u9752\u5c9b\u5206\u522b\u5efa\u7acb\u5168\u7403\u751f\u4ea7\u4f9b\u5e94\u57fa\u5730\uff0c\u5df2\u5411\u7ea6 80 \u4e2a\u5168\u7403\u5e02\u573a\u8f93\u9001\u4f18\u8d28\u836f\u54c1\u3002\u8fd1\u5e74\u6765\uff0c\u516c\u53f8\u5206\u522b\u5728\u5317\u4eac\u3001\u5e7f\u5dde\u3001\u676d\u5dde\u3001\u6210\u90fd\u3001\u9752\u5c9b\u8bbe\u7acb\u533a\u57df\u603b\u90e8\u3002\u963f\u65af\u5229\u5eb7\u8fd8\u643a\u624b\u5408\u4f5c\u4f19\u4f34\uff0c\u901a\u8fc7\u6253\u9020\u5305\u62ec\u4e2d\u56fd\u667a\u6167\u5065\u5eb7\u521b\u65b0\u4e2d\u5fc3\uff08CCiC\uff09\u3001\u56fd\u9645\u751f\u547d\u79d1\u5b66\u521b\u65b0\u56ed\uff08iCampus\uff09\u3001\u963f\u65af\u5229\u5eb7\u4e2d\u91d1\u533b\u7597\u4ea7\u4e1a\u57fa\u91d1\u5728\u5185\u7684\u521b\u65b0\u201c\u4e09\u9a7e\u9a6c\u8f66\u201d\uff0c\u6784\u5efa\u591a\u5143\u5316\u7684\u56fd\u9645\u521b\u65b0\u5065\u5eb7\u751f\u6001\u5708\uff0c\u5171\u540c\u4fc3\u8fdb\u533a\u57df\u7ecf\u6d4e\u4ee5\u53ca\u5927\u5065\u5eb7\u884c\u4e1a\u7684\u957f\u8db3\u53d1\u5c55\u3002\u4eca\u5929\uff0c\u4e2d\u56fd\u5df2\u7ecf\u53d1\u5c55\u6210\u4e3a\u963f\u65af\u5229\u5eb7\u5168\u7403\u7b2c\u4e8c\u5927\u5e02\u573a\u3002<\/span><\/p>\n<p><b><span>\u53c2\u8003\u6587\u732e<\/span><\/b><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[1] <\/sup>\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a,\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u8bca\u7597\u89c4\u8303\uff082021\u5e74\u7248\uff09[J]. 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[2] <\/sup>Gross A M, Wolters P L, Dombi E, et al. New England Journal of Medicine, 2020, 382(15): 1430-1442. doi: 10.1056\/NEJMoa1912735.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[3] <\/sup>I \u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u591a\u5b66\u79d1\u8bca\u7597\u6307\u5357\uff082023 \u7248\uff09[J], 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[4] <\/sup>ERN GENTURIS tumour surveillance guidelines for individuals with neurofibromatosis type 1.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[5] <\/sup>I\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u4e34\u5e8a\u8bca\u7597\u4e13\u5bb6\u5171\u8bc6 (2021).<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[6] <\/sup>Buono FD, et al. J Pain Res. 2019 Aug 22;122555 2561.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[7] <\/sup>Bellampalli SS, et al. Pain. 2019 May;160(5)1007 1018.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[8] <\/sup>Hirbe AC, et al . Lancet Neurol. 2014 Aug;13(8)834 43.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[9] <\/sup>Blakeley JO et al. Neuro Oncol. 2016;18(5)624 638.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[10]&nbsp;<\/sup>Yang X, et al. Childs Nerv Syst. 2022 May 17.&nbsp;<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[11]&nbsp;<\/sup>Hirbe AC, Gutmann DH. Neurofibromatosis type 1: a multidisciplinary approach to care. Lancet Neurol. 2014;13:834-43. doi: 10.1016\/S1474-4422(14)70063-8.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[12]&nbsp;<\/sup>National Institute of Neurological Disorders and Stroke. Neurofibromatosis Fact Sheet. Available at: \u201cWhat is NF1?\u201d Available at: <a href=\"http:\/\/www.ninds.nih.gov\/disorders\/patient-caregiver-education\/fact-sheets\/neurofibromatosis-fact-sheet\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">www.ninds.nih.gov\/disorders\/patient-caregiver-education\/fact-sheets\/neurofibromatosis-fact-sheet<\/a>. Last accessed: August 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[13]&nbsp;<\/sup>NHS. Neurofibromatosis Type 1, Symptoms. Available at <a href=\"https:\/\/www.nhs.uk\/conditions\/neurofibromatosis-type-1\/symptoms.%20Accessed%20August%202023\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.nhs.uk\/conditions\/neurofibromatosis-type-1\/symptoms. Accessed August 2023<\/a>.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[14]&nbsp;<\/sup>Evans DGR, Ingham SL. Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors. Appl Clin Genet. 2013;6:53-61.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[15]&nbsp;<\/sup>EClinicalMedicine.2023 Jan 13;56:101818. doi: 10.1016\/j.eclinm.2022.101818. eCollection 2023 Feb.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[16]&nbsp;<\/sup>Dombi E, Baldwin A, Marcus LJ, et al. Activity of selumetinib in neurofibromatosis type 1-related plexiform neurofibromas. N Engl J Med. 2016;375:2550-2560. doi: 10.1056\/NEJMoa1605943.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[17]&nbsp;<\/sup>Mayo Clinic. Neurofibromatosis. Available at: <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/neurofibromatosis\/symptoms-causes\/syc-20350490\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.mayoclinic.org\/diseases-conditions\/neurofibromatosis\/symptoms-causes\/syc-20350490<\/a>. Accessed July 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[18]&nbsp;<\/sup>Koselugo (selumetinib) Chinese prescribing information; 2023.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p><span>&nbsp;<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772023\u5e749\u67081\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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\u53c2\u8003\u6587\u732e [1] \u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a,\u513f\u7ae5\u53ca\u9752\u5c11\u5e74\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u8bca\u7597\u89c4\u8303\uff082021\u5e74\u7248\uff09[J]. 2021. [2] Gross A M, Wolters P L, Dombi E, et al. New England Journal of Medicine, 2020, 382(15): 1430-1442. doi: 10.1056\/NEJMoa1912735. 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