{"id":93658,"date":"2023-09-01T17:55:00","date_gmt":"2023-09-01T10:55:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023090117550093658"},"modified":"2023-09-02T22:41:39","modified_gmt":"2023-09-02T14:41:39","slug":"%e5%a4%a9%e6%bc%94%e8%8d%af%e4%b8%9a%ef%bc%88adagene-inc-nasdaq%ef%bc%9aadag%ef%bc%89%e5%85%ac%e5%b8%832023%e5%b9%b4%e4%b8%8a%e5%8d%8a%e5%b9%b4%e8%b4%a2%e5%8a%a1%e4%b8%9a%e7%bb%a9%e5%8f%8a%e5%85%ac","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023090117550093658","title":{"rendered":"\u5929\u6f14\u836f\u4e1a\uff08Adagene Inc., NASDAQ\uff1aADAG\uff09\u516c\u5e032023\u5e74\u4e0a\u534a\u5e74\u8d22\u52a1\u4e1a\u7ee9\u53ca\u516c\u53f8\u8fdb\u5c55"},"content":{"rendered":"<p class=\"prntac\"><i>&#8211;<\/i><i>\u6297<\/i><i>CTLA-4<\/i><i>\u5019\u9009\u6297\u4f53\u4ece\u8bbe\u8ba1\u4e0a\u63d0\u5347\u4e86\u6cbb\u7597\u6307\u6570<\/i><i>30<\/i><i>\u500d\u4ee5\u4e0a\uff0c\u81f4\u529b\u4e8e<\/i><i>CTLA-4<\/i><i>\u4ecb\u5bfc\u8c03\u8282\u6027<\/i><i>T<\/i><i>\u7ec6\u80de\uff08<\/i><i>Treg<\/i><i>\uff09\u6e05\u9664\u4ee5\u8fdb\u4e00\u6b65\u63d0\u5347\u60a3\u8005\u7597\u6548\uff0c<\/i>&nbsp;<i>\u5177\u5907\u540c\u7c7b\u6700\u4f73\u6f5c\u529b<\/i><\/p>\n<p class=\"prntac\"><i>&#8211;<\/i><i>\u5b89\u5168\u6297\u4f53<\/i><i>SAFEbody<sup>&reg;<\/sup> ADG126<\/i><i>\u5728<\/i><i>10 mg\/kg<\/i><i>\u5242\u91cf\u4e0b\u6bcf<\/i><i>3<\/i><i>\u5468\u7ed9\u836f\u4e00\u6b21\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\uff0c\u9488\u5bf9\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08<\/i><i>MSS<\/i><i>\uff09\u7ed3\u76f4\u80a0\u764c\uff08<\/i><i>CRC<\/i><i>\uff09\u7684\u5355\u81c2<\/i><i>2<\/i><i>\u671f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u5f3a\u70c8\u7684\u7597\u6548\u4fe1\u53f7<\/i><\/p>\n<p class=\"prntac\"><i>&#8211;<\/i><i>\u6839\u636e<\/i><i>Simon<\/i><i>\u4e24\u9636\u6bb5\u7684<\/i><i>2<\/i><i>\u671f\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u57fa\u4e8e<\/i><i>10 mg\/kg<\/i><i>\u5242\u91cf\u6bcf<\/i><i>3<\/i><i>\u5468\u4e00\u6b21\u7684\u7ed9\u836f\u9891\u7387\uff0c\u5b89\u5168\u6297\u4f53<\/i><i>SAFEbody<sup>&reg;<\/sup> ADG126<\/i><i>\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u9488\u5bf9\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u62d3\u5c55\u961f\u5217<\/i><i>\u6b63\u5728\u5165\u7ec4\u7b2c\u4e8c\u9636\u6bb5\u7684<\/i><i>10<\/i><i>\u4f8b<\/i><i>\u60a3\u8005<\/i><\/p>\n<p class=\"prntac\"><i>&#8211;<\/i><i>\u7f57\u6c0f\u542f\u52a8\u4e86\u5b89\u5168\u6297\u4f53<\/i><i>SAFEbody<sup>&reg;<\/sup>ADG126<\/i><i>\u539f\u521b\u4e09\u8054\u5f3a\u529b\u7597\u6cd5\u809d\u7ec6\u80de\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u968f\u673a<\/i><i><span class=\"xn-money\">1b<\/span>\/2<\/i><i>\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/i><\/p>\n<p class=\"prntac\"><i>-1.288<\/i><i>\u4ebf\u7f8e\u5143\u7684\u73b0\u91d1\u53ef\u652f\u6301\u516c\u53f8\u81f3<\/i><i>2025<\/i><i>\u5e74\u5e95\u7684\u8fd0\u8425\u6d3b\u52a8<\/i><\/p>\n<p><p><span class=\"legendSpanClass\">\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5<\/span><span class=\"legendSpanClass\">2023\u5e749\u67081\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u5929\u6f14\u836f\u4e1a\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;\u516c\u53f8&quot;\u6216&quot;\u5929\u6f14&quot;\uff09\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u4e00\u5bb6\u5e73\u53f0\u9a71\u52a8\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u7597\u6cd5\u3002\u516c\u53f8\u4eca\u65e5\u516c\u5e03\u4e86\u622a\u81f32023\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u8d22\u52a1\u4e1a\u7ee9\u53ca\u6700\u65b0\u4e1a\u52a1\u8fdb\u5c55\u3002<\/p>\n<p>\u5929\u6f14\u9996\u5e2d\u6267\u884c\u5b98\u3001\u8463\u4e8b\u957f\u517c\u7814\u53d1\u603b\u88c1\u7f57\u57f9\u5fd7\u535a\u58eb\u8868\u793a\uff1a&quot;\u76ee\u524d\u6211\u4eec\u81ea\u7814\u7684\u6297CTLA-4\u9879\u76ee\u4e34\u5e8a\u6570\u636e\u8868\u660e\uff0c\u901a\u8fc7\u5408\u9002\u7684\u7ed9\u836f\u65b9\u6848\u53ef\u63d0\u9ad8\u6297CTLA-4\u7597\u6cd5\u6cbb\u7597\u6307\u6570\u5e76\u91ca\u653e\u5176\u4e34\u5e8a\u6f5c\u80fd\uff0c\u4e3a\u4e0ePD-1\u53ca\u4e0e\u5176\u4ed6\u836f\u7269\u7684\u8054\u5408\u6cbb\u7597\u5960\u5b9a\u57fa\u7840\u3002\u5f97\u76ca\u4e8e\u4f18\u5f02\u7684\u5b89\u5168\u6027\u548c\u591a\u6b21\u91cd\u590d\u7ed9\u836f\u65b9\u6848\uff0c\u6211\u4eec\u5728\u6700\u521d\u5165\u7ec4\u7684\u60a3\u8005\u5305\u62ec\u51b7\u80bf\u7624\uff08\u5982\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff09\u60a3\u8005\u548cPD-L1\u4f4e\u8868\u8fbe\u60a3\u8005\u53caPD-1\u8010\u836f\u6027\u70ed\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4e0a\u89c2\u5bdf\u5230\u4e86\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u4e34\u5e8a\u7f13\u89e3\uff0c\u4f53\u73b0\u4e86&nbsp;CTLA-4 \u4ecb\u5bfc\u7684&nbsp;Treg \u6e05\u9664\u5bf9\u4e8e\u7597\u6548\u7ed3\u679c\u81f3\u5173\u91cd\u8981\u3002&quot;<\/p>\n<p>\u7f57\u535a\u58eb\u7ee7\u7eed\u8865\u5145\u9053\uff1a&quot;\u8fd9\u4e9b\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u4f7f\u6211\u4eec\u80fd\u591f\u9996\u6b21\u5728\u665a\u671f\/\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u8fd9\u4e00\u7279\u5b9a\u80bf\u7624\u60a3\u8005\u4e2d\u8bc4\u4f30 ADG126\u8054\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u7597\u6548\uff0c\u8be5\u5355\u81c2\u4e34\u5e8a2\u671f\u8bd5\u9a8c\u91c7\u7528\u4e86Simon\u4e24\u9636\u6bb5\u8bbe\u8ba1\u3002\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u5728\u7b2c\u4e00\u9636\u6bb5\u89c2\u5bdf\u5230\u5f3a\u70c8\u7684\u7597\u6548\u4fe1\u53f7\uff0c \u987a\u5229\u8fdb\u5165\u7b2c\u4e8c\u9636\u6bb5\u7684\u60a3\u8005\u5165\u7ec4\u5de5\u4f5c\uff0c\u7ed9\u836f\u5242\u91cf\u4e3a10 mg\/kg\uff0c\u6bcf3\u5468\u4e00\u6b21\u3002\u6211\u4eec\u5bf9\u7a81\u7834\u6297CTLA-4 \u7597\u6cd5\u7684\u8fb9\u754c\uff0c\u81f4\u529b\u4e8e\u63d0\u9ad8\u764c\u75c7\u6cbb\u7597\u7684\u80fd\u529b\u5145\u6ee1\u4fe1\u5fc3\u3002&quot;<\/p>\n<p><b>\u6297<\/b><b>CTLA-4<\/b><b>\u9879\u76ee\u4eae\u70b9<\/b><\/p>\n<ul type=\"disc\">\n<li><b><i><span id=\"spanHghlte672\"><span class=\"xn-money\">1b<\/span><\/span>\/2<\/i><\/b><b><i>\u671f\u6570\u636e\u8868\u660e\uff0c\u9776\u5411\u72ec\u7279\u8868\u4f4d\u7684\u6297<\/i><\/b><b><i>CTLA-4<\/i><\/b><b><i>\u975e\u63a9\u853d\u578b\u65b0\u8868\u4f4d\u6297\u4f53<\/i><\/b><b><i>NEObody&#x2122; ADG116<\/i><\/b><b><i>\u5728\u5355\u4e00\u7597\u6cd5\u4ee5\u53ca\u4e0e\u6297<\/i><\/b><b><i>PD-1<\/i><\/b><b><i>\u7684\u8054\u5408\u7597\u6cd5\u4e2d\u5747\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u4e34\u5e8a\u7f13\u89e3\u3002<\/i><\/b><\/li>\n<\/ul>\n<ul type=\"disc\">\n<li style=\"list-style-type: none\">&nbsp;<\/li>\n<ul type=\"disc\">\n<li>ADG116\u5355\u4e00\u7597\u6cd5\u5728\u6700\u9ad8\u5242\u91cf\u8fbe\u5230<span id=\"spanHghlt5ac6\">15 mg\/kg<\/span>\uff08N=59\uff09\u7684\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/li>\n<li>\u5728\u9488\u5bf9\u7ecf\u8fc7\u5927\u91cf\u9884\u6cbb\u7597\u7684\u80bf\u7624\u60a3\u8005\u7684\u6cbb\u7597\u4e2d\uff0cADG116\u5355\u4e00\u7597\u6cd5\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523013%\uff083\/23\u53ef\u8bc4\u4f30\uff09\uff0c\u5176\u4e2d\uff0c<i>\u80be\u7ec6\u80de\u764c<\/i>\uff08RCC\uff09\u60a3\u8005\u4e0e\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff08MSI-H\uff09\u578b\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u89c2\u5bdf\u5230\u786e\u8ba4\u7684\u90e8\u5206\u7f13\u89e3\uff08PR\uff09<i>\uff0c<\/i>\u5361\u6ce2\u897f\u6c0f\u8089\u7624\u60a3\u8005\u89c2\u5bdf\u5230\u521d\u6b65\u7f13\u89e3\u3002<\/li>\n<li>\u4e0e\u6297PD-1\u7597\u6cd5\uff08N=22\uff09\u7684\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5728\u5242\u91cf\u6c34\u5e73\u4e3a3 mg\/kg\u4e14\u6bcf6\u5468\u7ed9\u836f\u4e00\u6b21\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u4e2d\uff0cADG116\u5c55\u73b0\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u4e0e\u4ee4\u4eba\u9f13\u821e\u7684\u6709\u6548\u6027\u3002\u6b63\u5728\u8fdb\u884c\u7684\u8054\u5408\u6cbb\u7597\u961f\u5217\u4e2d\u89c2\u5bdf\u5230\u4e34\u5e8a\u7f13\u89e3\uff0c\u5176\u4e2d\uff0c\u4e00\u4f4d\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u60a3\u8005\u5728\u5242\u91cf\u6c34\u5e73\u4e3a3 mg\/kg\uff08\u6700\u521d\u6bcf3\u5468\u7ed9\u836f\uff0c\u7136\u540e\u6bcf6\u5468\u7ed9\u836f\uff09\u7684ADG116\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u6301\u7eed\u8d85\u8fc7\u4e00\u5e74\u7684\u6301\u4e45\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff08ORR = 20%\uff1b1\/5\u53ef\u8bc4\u4f30\uff09\u3002<\/li>\n<li>\u6b64\u5916\uff0c\u4e00\u4f4d\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5728ADG116\uff08\u5242\u91cf\u6c34\u5e73\u4e3a<span id=\"spanHghlt4ca4\">3 mg\/kg<\/span>\uff0c\u6bcf6\u5468\u7ed9\u836f\uff09\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u521d\u6b65\u90e8\u5206\u7f13\u89e3\u3002<\/li>\n<li>ADG116\u5df2\u89c2\u5bdf\u5230\u4e34\u5e8a\u7597\u6548\uff0c\u5e76\u51c6\u5907\u5728\u5408\u7406\u914d\u5907\u8d44\u6e90\u540e\u8fdb\u5165\u968f\u673a2\u671f\u8bd5\u9a8c\uff0c\u5176\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u5242\u91cf\u6269\u5c55\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30ADG116\u4e0e\u6297PD-1\u836f\u7269\u8054\u5408\u6cbb\u7597\u7684\u7597\u6548\u3002<\/li>\n<\/ul>\n<\/ul>\n<ul type=\"disc\">\n<li><b><i>\u6765\u81ea\u9ad8\u5242\u91cf\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u7684<\/i><\/b><b><i>ADG126 <span class=\"xn-money\">1b<\/span>\/2<\/i><\/b><b><i>\u671f\u4e34\u5e8a\u6570\u636e\u8868\u660e\uff0c\u4e0e<\/i><\/b><b><i>ADG116<\/i><\/b><b><i>\u9776\u5411\u540c\u4e00\u72ec\u7279\u8868\u4f4d\u7684\u7cbe\u51c6\u63a9\u853d\u578b\u6297<\/i><\/b><b><i>CTLA-4<\/i><\/b><b><i>\u5b89\u5168\u6297\u4f53<\/i><\/b><b><i>SAFEbody&reg; ADG126<\/i><\/b><b><i>\u5728\u5355\u4e00\u6cbb\u7597\u4e0e\u8054\u5408\u7597\u6cd5\u4e2d\u5747\u5c55\u73b0\u51fa\u4ee4\u4eba\u4fe1\u670d\u7684\u5b89\u5168\u6027\u4e0e\u826f\u597d\u7684\u6709\u6548\u6027\uff1a<\/i><\/b><\/li>\n<\/ul>\n<ul type=\"disc\">\n<li style=\"list-style-type: none\">&nbsp;<\/li>\n<ul type=\"disc\">\n<li>2023\u5e74\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0c\u5728\u9488\u5bf9\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u6700\u9ad8\u5242\u91cf\u4e3a20 mg\/kg\u4e14\u6bcf\u4e09\u5468\u91cd\u590d\u7ed9\u836f\u7684\u5355\u4e00\u7597\u6cd5\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u4e2d\uff0cADG126\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u4e0e3\u7ea7\u6216\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08N=30\uff09\u3002<\/li>\n<li>\u5728\u4e0e\u6297PD-1\u836f\u7269\u8054\u5408\u7597\u6cd5\uff08N=31\uff09\u4e2d\uff0c\u5305\u62ec\u6bcf3\u5468\u62166\u5468\u4ee510 mg\/kg\u7684\u5242\u91cf\u6c34\u5e73\u91cd\u590d\u7ed9\u836f\u8d85\u8fc74\u4e2a\u5468\u671f\uff0cADG126\u4e5f\u8868\u73b0\u51fa\u4e0e\u6297PD-1\u836f\u7269\u53cc\u8054\u7684\u540c\u7c7b\u6700\u4f73\u7684\u5b89\u5168\u6027\uff0c\u672a\u6765\u6709\u671b\u4e0e\u5176\u4ed6\u836f\u7269\u4e09\u8054\u4f7f\u7528\u3002<\/li>\n<li>\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0cADG126\uff08\u5242\u91cf\u6c34\u5e7310 mg\/kg\uff09\u5728\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u6709\u6548\u6027\uff0c\u5305\u62ec\u5728\u809b\u95e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u548c\u9634\u830e\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e24\u4f8b\u786e\u8ba4\u7684\u90e8\u5206\u7f13\u89e3\uff0c\u4ee5\u53ca\u5728\u51b7\u80bf\u7624\uff08\u5305\u62ec\u809d\u8f6c\u79fb\u7684\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff09\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u660e\u663e\u80bf\u7624\u840e\u7f29\uff08\u9776\u75c5\u7076\u7f29\u5c0f\u226520% \uff09\u548c\u6301\u7eed\u75c5\u60c5\u7a33\u5b9a\u3002<\/li>\n<li>\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0c\u53e6\u4e00\u4f8b\u786e\u8ba4\u90e8\u5206\u7f13\u89e3\u6765\u81ea\u4e00\u4f4d\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\uff0c\u8be5\u60a3\u8005\u63a5\u53d7\u4e86\u5242\u91cf\u6c34\u5e73\u4e3a10 mg\/kg\u7684ADG126\u4e0e\u6297PD-1\u6291\u5236\u5242\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\u3002<\/li>\n<li>\u5728\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u5e74\u4f1a\u4e4b\u540e\uff0c\u63a5\u53d7ADG126\uff08\u5242\u91cf\u6c34\u5e7310 mg\/kg\uff09\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u5242\u91cf\u62d3\u5c55\u961f\u5217\uff0c\u5728\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5916\uff0c\u53c8\u89c2\u5bdf\u5230\u53e6\u4e24\u4f8b\u786e\u8ba4\u7684\u4e34\u5e8a\u7f13\u89e3\u3002<\/li>\n<ul type=\"disc\">\n<li>\u4e00\u4f8b\u786e\u8ba4\u90e8\u5206\u7f13\u89e3\u6765\u81ea\u4e00\u4f4d\u5bab\u9888\u764c\u60a3\u8005\uff0c\u8be5\u60a3\u8005\u5728\u65e2\u5f80\u4e24\u7ebf\u6cbb\u7597\uff08\u5305\u542b9\u4e2a\u5468\u671f\u7684\u5e15\u535a\u5229\u73e0\u5355\u6297\u5355\u4e00\u6cbb\u7597\uff09\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u7b26\u5408PD-1\u8010\u836f\u6807\u51c6\u3002<\/li>\n<li>\u4e00\u4f4d\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u89c2\u5bdf\u5230\u786e\u8ba4\u90e8\u5206\u7f13\u89e3\u4ee5\u53ca\u9776\u75c5\u7076\u5b8c\u5168\u840e\u7f29\u3002\u60a3\u8005\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\uff0cCPS\u8bc4\u5206\u8f83\u4f4e\u3002<\/li>\n<\/ul>\n<li>\u5728\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u9636\u6bb5\u63a5\u53d7\u5242\u91cf\u6c34\u5e73\u4e3a10 mg\/kg\u4e14\u6bcf3\u5468\u7ed9\u836f\u7684ADG126\u4e0e\u6297PD-1\u8054\u5408\u6cbb\u7597\u7684\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\uff0c\u89c2\u5bdf\u523040%\u7684\u603b\u7f13\u89e3\u7387\uff084\/10\uff09\uff0c\u4ee5\u53ca10%\u76843\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u6982\u7387\uff0c\u672a\u89c2\u5bdf\u52303\u7ea7\u4ee5\u4e0a\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e5f\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u5728\u6bcf6\u546810 mg\/kg\u548c\u6bcf3\u54686 mg\/kg\u7684\u7ed9\u836f\u9891\u7387\u548c\u5242\u91cf\u4e0b\u540c\u6837\u4e5f\u89c2\u5bdf\u5230\u4e86\u4e34\u5e8a\u7597\u6548\u3002<\/li>\n<li>\u9488\u5bf9\u65e0\u809d\u8f6c\u79fb\u7684\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u665a\u671f\u7ed3\u76f4\u80a0\u764c\u7684\u5242\u91cf\u6269\u5c55\u961f\u5217\u91c7\u7528\u4e86\u4e24\u7ec4\u7ed9\u836f\u65b9\u6848\uff1a\u5206\u522b\u662fADG126\uff0c10 mg\/kg\uff0c\u6bcf6\u5468\u7ed9\u836f\uff0810\u540d\u60a3\u8005\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u53caADG126 10 mg\/kg\uff0c\u6bcf3\u5468\u7ed9\u836f\uff0813\u540d\u60a3\u8005\uff09\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u3002\u57fa\u4e8e10 mg\/kg\u5242\u91cf\u6c34\u5e73\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\u7684\u7ed9\u836f\u9891\u7387\u4e0b\u89c2\u5bdf\u5230\u66f4\u6709\u529b\u7684\u7597\u6548\u4fe1\u53f7\uff0c\u6839\u636eSimon\u4e24\u9636\u6bb5\u7684\u4e8c\u671f\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u516c\u53f8\u9700\u8981\u5728\u8be5\u7ed9\u836f\u65b9\u6848\u4e0b\u7ee7\u7eed\u62db\u52df10\u4f8b\u60a3\u8005\uff0c\u5176\u521d\u6b65\u6709\u6548\u6027\u6570\u636e\u8bc4\u4f30\u53ca\u7edf\u8ba1\u5206\u6790\u9884\u8ba1\u5c06\u4e8e2023\u5e74\u5e95\u62162024\u5e74\u521d\u516c\u5e03\u3002<\/li>\n<\/ul>\n<\/ul>\n<p><b><u>\u5176\u5b83\u6700\u65b0\u52a8\u6001<\/u><\/b><\/p>\n<ul type=\"disc\">\n<li><b><i>\u7f57\u6c0f\uff1a<\/i><\/b> \u6839\u636e<a href=\"\/Users\/ying_wu\/AppData\/Local\/Microsoft\/Windows\/INetCache\/Content.Outlook\/66JIWTMR\/2022%E5%B9%B412%E6%9C%88%E7%AD%BE%E8%AE%A2%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E5%90%88%E4%BD%9C%E5%8D%8F%E8%AE%AE\" target=\"_blank\" rel=\"nofollow noopener\">2022\u5e7412\u6708\u7b7e\u8ba2\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5408\u4f5c\u534f\u8bae<\/a>\uff0c\u7f57\u6c0f\u542f\u52a8\u4e86\u4e00\u9879\u8de8\u56fd1b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5bf9\u7167\u7f57\u6c0f\u7684\u963f\u66ff\u5229\u73e0\u5355\u6297\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u8bc4\u4f30ADG126\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u4e4b\u4e09\u8054\u514d\u75ab\u7597\u6cd5\u5728\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u3002\u8be5\u968f\u673a\u8bd5\u9a8c\u76ee\u524d\u5df2\u542f\u52a8\u60a3\u8005\u5165\u7ec4\u5de5\u4f5c\uff0c\u8ba1\u5212\u7eb3\u5165\u591a\u8fbe60\u540d\u60a3\u8005\uff0c\u5229\u7528\u7f57\u6c0f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5f00\u53d1\u5e73\u53f0MORPHEUS\u9879\u76ee\u7684\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\u7f51\u7edc\u3002\u7f57\u6c0f\u6b63\u8d5e\u52a9\u5e76\u5f00\u5c55\u8be5\u8bd5\u9a8c\uff0c\u5929\u6f14\u5c06\u4fdd\u7559\u5bf9ADG126\u7684\u5168\u7403\u5f00\u53d1\u4e0e\u5546\u54c1\u5316\u6743\u5229\u3002<\/li>\n<li><b><i>Exelixis<\/i><\/b><b><i>\uff1a<\/i><\/b>\u6839\u636e\u53cc\u65b9\u4e3a\u5f00\u53d1\u539f\u521b\u63a9\u853d\u578b\u6297\u4f53\u5076\u8054\u836f\u7269\u800c\u8fbe\u6210\u7684\u6280\u672f\u6388\u6743\u534f\u8bae\uff0c2023\u5e746\u6708\uff0c\u5929\u6f14\u5728\u7b2c\u4e8c\u4e2a\u5408\u4f5c\u9879\u76ee\u4e2d\u6210\u529f\u7b5b\u9009\u5230\u76ee\u6807\u5b89\u5168\u6297\u4f53SAFEbody&reg;\u5019\u9009\u836f\u7269\uff0c\u5e76\u83b7\u5f97\u4e00\u7b14\u6765\u81eaExelixis\u7684300\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/li>\n<li><b><i>\u8d5b\u8bfa\u83f2<\/i><\/b><b>\uff1a<\/b>\u5929\u6f14\u4e0e\u8d5b\u8bfa\u83f2\u5ef6\u7eed\u53cc\u65b9\u4e8e2022\u5e743\u6708\u8fbe\u6210\u7684\u5408\u4f5c\uff0c\u5f00\u53d1\u53cc\u7279\u5f02\u6027\u548c\u5355\u514b\u9686SAFEbody&reg;\u5019\u9009\u6297\u4f53\uff0c\u5229\u7528\u5929\u6f14\u7684\u6280\u672f\u5236\u5907\u7684\u4e34\u5e8a\u524d\u5019\u9009\u6297\u4f53\uff0c\u7531\u8d5b\u8bfa\u83f2\u8fdb\u884c\u5f00\u53d1\u548c\u5546\u54c1\u5316\u3002<\/li>\n<li><b><i>ADC Therapeutics <\/i><\/b><b><i>\uff08<\/i><\/b><b><i>ADCT<\/i><\/b><b><i>\uff09\uff1a<\/i><\/b>\u622a\u81f3\u672c\u516c\u544a\u53d1\u5e03\u4e4b\u65e5\uff0cADCT\u4e0e\u5929\u6f14\u4e8e2019\u5e744\u6708\u7b7e\u8ba2\u7684\u751f\u7269\u6750\u6599\u8f6c\u79fb\u4e0e\u5408\u4f5c\u534f\u8bae\u5df2\u7ecf\u5230\u671f\uff0cADCT\u9009\u62e9\u4e0d\u884c\u4f7f\u5176\u5bf9\u76f8\u5173\u8bb8\u53ef\u534f\u8bae\u7684\u9009\u62e9\u6743\u3002\u672a\u6765\uff0c\u53cc\u65b9\u5c06\u4fdd\u6301\u5f00\u653e\u6001\u5ea6\uff0c\u7ee7\u7eed\u63a2\u7d22\u5728\u521b\u65b0\u6297\u4f53\u7597\u6cd5\u7684\u53d1\u73b0\u548c\u5f00\u53d1\u65b9\u9762\u7684\u5408\u4f5c\u673a\u4f1a\u3002<\/li>\n<li><b><i>ADG153<\/i><\/b><b><i>\uff08\u6297<\/i><\/b><b><i>CD47 IgG1<\/i><\/b><b><i>\u5b89\u5168\u6297\u4f53<\/i><\/b><b><i>SAFEbody&reg;<\/i><\/b><b><i>\uff09\uff1a<\/i><\/b>\u5929\u6f14\u5728\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0cADG153\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u540c\u7c7b\u6700\u4f73\u6f5c\u529b\uff0cADG153\u662f\u4e00\u79cdIgG1\u4e9a\u578b\u5019\u9009\u6297\u4f53\uff0c\u91c7\u7528\u5b89\u5168\u6297\u4f53SAFEbody&reg;\u7cbe\u51c6\u63a9\u853d\u6280\u672f\u4f18\u5316\u5176\u5b89\u5168\u6027\uff0c\u6b63\u5904\u4e8e\u65b0\u836f\u7533\u8bf7\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u3002\u8be5<a href=\"\/Users\/ying_wu\/AppData\/Local\/Microsoft\/Windows\/INetCache\/Content.Outlook\/66JIWTMR\/poster%20presentation\" target=\"_blank\" rel=\"nofollow noopener\">\u6d77\u62a5\u5c55\u793a<\/a>\u603b\u7ed3\u4e86\u76f8\u5173\u6570\u636e\uff0c\u8868\u660eADG153\u5728\u5b9e\u4f53\u7624\u6a21\u578b\u4e2d\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e14\u4f18\u5148\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4e0eCD47\u9776\u70b9\u7ed3\u5408\uff0c\u56e0\u800c\u5177\u5907\u51fa\u4f17\u7684\u5b89\u5168\u6027\u3002ADG153\u5177\u6709\u5f88\u5f3a\u7684\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff08ADCC\uff09\u548c\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u541e\u566c\u4f5c\u7528\uff08ADCP\uff09\uff0c\u65e8\u5728\u5145\u5206\u91ca\u653e\u6297 CD47 \u6cbb\u7597\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u6076\u6027\u80bf\u7624\u7684\u6f5c\u529b\u3002<\/li>\n<li><b><i>\u8463\u4e8b\u4f1a\u6700\u65b0\u52a8\u6001\uff1a<\/i><\/b>\u4eca\u5e748\u6708\uff0c\u5929\u6f14\u4efb\u547d\u6731\u529b\u535a\u58eb\u4e3a\u8463\u4e8b\u4f1a\u6210\u5458\u3002\u6731\u535a\u58eb\u81ea2020\u5e74\u8d77\u62c5\u4efb\u91d1\u65af\u745e\u53ca\u4f20\u5947\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08Legend Biotech\uff09\u8463\u4e8b\uff0c\u76ee\u524d\u662f\u91d1\u65af\u745e\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08Genscript Biotech Corporation\uff09\u7684\u9996\u5e2d\u6218\u7565\u5b98\uff0c\u5176\u5728\u4f01\u4e1a\u6218\u7565\u3001\u6218\u7565\u5408\u4f5c\u53ca\u8054\u76df\u7ba1\u7406\u65b9\u9762\u62e5\u6709\u7740\u4e30\u5bcc\u7684\u7ecf\u9a8c\uff0c\u5c24\u5176\u5728\u4f20\u5947\u751f\u7269\uff08\u91d1\u65af\u745e\u7684\u5b50\u516c\u53f8\uff09\u548c\u8de8\u56fd\u836f\u4f01\u6218\u7565\u5408\u4f5c\u8c08\u5224\u7684\u65e9\u671f\u9636\u6bb5\u53d1\u6325\u4e86\u5173\u952e\u4f5c\u7528\u3002<br \/>\u6b64\u5916\uff0c\u675c\u65b9\u52c7\u535a\u58eb\uff0c<span id=\"spanHghltcf00\">2020\u5e74<\/span>\u8d77\u4efb\u5929\u6f14\u9996\u5e2d\u6280\u672f\u5b98\uff0c\u56e0\u4e2a\u4eba\u539f\u56e0\u9000\u51fa\u8463\u4e8b\u4f1a\u3002\u540c\u65f6\uff0c\u516c\u53f8\u4efb\u547d\u5929\u6f14\u521b\u59cb\u56e2\u961f\u6210\u5458\uff0c\u751f\u7269\u4fe1\u606f\u79d1\u6280\u9ad8\u7ea7\u526f\u603b\u88c1\u674e\u8273\u62c5\u4efb\u8463\u4e8b\u4e00\u804c\u3002<br \/>\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\uff0c\u5929\u6f14\u516c\u5e03\u4e86\u8463\u4e8b\u4f1a\u7684\u6700\u65b0\u52a8\u6001\uff1aMervyn Turner\u535a\u58eb\uff0c\u9ed8\u6c99\u4e1c\u7814\u7a76\u5b9e\u9a8c\u5ba4\uff08Merck research Laboratories\uff09\u524d\u5168\u7403\u8bb8\u53ef\u548c\u5916\u90e8\u7814\u7a76\u90e8\u95e8\u8d1f\u8d23\u4eba\uff0c\u88ab\u4efb\u547d\u4e3a\u8463\u4e8b\uff1b\u738b\u96e8\u6fdb\u63a5\u66ff\u5b59\u4e50\u975e\u62c5\u4efb\u7531\u6cdb\u5927\u897f\u6d0b\u6295\u8d44\u96c6\u56e2\u65b0\u52a0\u5761\u529e\u4e8b\u5904\uff08General Atlantic Singapore AI Pte. Ltd\uff09\u6307\u5b9a\u7684\u8463\u4e8b\uff1b\u5218\u6bd3\u6587\u56e0\u9996\u6b21\u4efb\u671f\u5c4a\u6ee1\uff0c\u8f9e\u53bb\u8463\u4e8b\u4f1a\u53ca\u5ba1\u8ba1\u59d4\u5458\u4f1a\u6210\u5458\u804c\u52a1\u3002<\/li>\n<li><b><i>\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\uff1a<\/i><\/b>\u4eca\u5e743\u6708\uff0c<a href=\"\/Users\/ying_wu\/AppData\/Local\/Microsoft\/Windows\/INetCache\/Content.Outlook\/66JIWTMR\/Professor%20Aur%C3%A9lien%20Marabelle,%20MD,%20PhD\" target=\"_blank\" rel=\"nofollow noopener\">\u533b\u5b66\u535a\u58ebAur&eacute;lien Marabelle\u6559\u6388<\/a>\u88ab\u4efb\u547d\u4e3a\u516c\u53f8\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\u6210\u5458\u3002Marabelle\u6559\u6388\u662f\u6cd5\u56fdGustave Roussy\u764c\u75c7\u4e2d\u5fc3\u836f\u7269\u5f00\u53d1\u90e8\uff08DITEP\uff09\u7684\u533b\u5b66\u79d1\u5b66\u5bb6\uff0c\u4e5f\u662f\u80bf\u7624\u5b66\u548c\u514d\u75ab\u5b66\u9886\u57df\u7684\u4e13\u5bb6\u3002\u4ed6\u5728\u80bf\u7624\u7279\u5f02\u6027\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u6e05\u9664\u65b9\u9762\u62e5\u6709\u6df1\u523b\u89c1\u89e3\uff0c\u5f00\u521b\u6027\u5730\u5f15\u5165\u80bf\u7624\u5185\u800c\u975e\u7cfb\u7edf\u7ed9\u836f\u6297CTLA-4\u7597\u6cd5\uff0c\u4ece\u800c\u514b\u670d\u6297CTLA-4\u7597\u6cd5\u5242\u91cf\u4f9d\u8d56\u6027\u6bd2\u6027\u95ee\u9898\u3002<\/li>\n<\/ul>\n<p><b>\u8d22\u52a1<\/b><b>\u4eae\u70b9<\/b><\/p>\n<p><u>\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269<\/u><br \/>\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u72692022\u5e7412\u670831\u65e5\u7ea614,380\u4e07\u7f8e\u5143\uff0c2023\u5e746\u670830\u65e5\u7ea612,880\u4e07\u7f8e\u5143\u3002<\/p>\n<p>\u622a\u81f32023\u5e746\u670830\u65e5\uff0c\u516c\u53f8\u4ece\u4e2d\u56fd\u5883\u5185\u5404\u5546\u4e1a\u94f6\u884c\u83b7\u5f97\u7684\u4eba\u6c11\u5e01\u8d37\u6b3e\u75312022\u5e7412\u670831\u65e5\u76842,780\u4e07\u7f8e\u5143\u51cf\u5c11\u81f32023\u5e746\u670830\u65e5\u76842,490\u4e07\u7f8e\u5143\u3002\u4ece\u8d37\u6b3e\u4e2d\u6240\u83b7\u5f97\u8d44\u91d1\u4e3b\u8981\u7528\u6765\u652f\u4ed8\u516c\u53f8\u5728\u4e2d\u56fd\u5883\u5185\u4ea7\u751f\u7684\u7814\u53d1\u8d39\u7528\uff0c\u5305\u62ec\u5728\u4e34\u5e8a\u53ca\u4e34\u5e8a\u524d\u7814\u53d1\u9879\u76ee\u4e2d\u4ea7\u751f\u7684CMC\u8d39\u7528\u3002<\/p>\n<p><u>\u51c0\u6536\u5165<\/u><br \/>\u51c0\u6536\u5165\u540c\u6bd4\u589e\u957f\u4e86\u7ea6341%\u3002\u51c0\u6536\u5165\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u7684390\u4e07\u7f8e\u5143\u589e\u52a0\u52302023\u5e746\u670830\u65e51,730\u4e07\u7f8e\u5143\u3002\u8be5\u589e\u957f\u5305\u542b\u4e86\u56e0\u516c\u53f8\u5c65\u884c\u4e86\u4e0e\u8d5b\u8bfa\u83f2\u548cExelixis\u6240\u5206\u522b\u7b7e\u8ba2\u7684\u6280\u672f\u5408\u4f5c\u548c\u6388\u6743\u534f\u8bae\u4e2d\u7684\u5c65\u7ea6\u4e49\u52a1\u800c\u786e\u8ba4\u7684\u6536\u5165\u3002\u51c0\u6536\u5165\u4e5f\u5305\u542b\u4e86\u4e8e2023\u5e746\u6708\u4eceExelixis\u6536\u5230\u7684300\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/p>\n<p><u>\u7814\u53d1\u8d39\u7528<\/u><\/p>\n<p>\u7814\u53d1\u8d39\u7528\u540c\u6bd4\u4e0b\u964d\u4e86\u7ea653%\u3002\u7814\u53d1\u8d39\u7528\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u76844,510\u4e07\u7f8e\u5143\u4e0b\u964d\u52302023\u5e746\u670830\u65e5\u76842,130\u4e07\u7f8e\u5143\u3002\u8be5\u4e0b\u964d\u6e90\u4e8e\u4e34\u5e8a\u524d\u9879\u76ee\u652f\u51fa\u7684\u51cf\u5c11\u548cADG106\u76f8\u5173\u7684\u4e34\u5e8a\u9879\u76ee\u7684\u9010\u6e10\u6536\u5c3e\uff0c\u4e0e\u9488\u5bf9\u6297CTLA-4\u7597\u6cd5\u589e\u52a0\u7684\u6295\u5165\u6240\u62b5\u6d88\u3002\u516c\u53f8\u91cd\u70b9\u53d1\u5c55\u4f18\u8d28\u4e34\u5e8a\u9879\u76ee\uff0c\u5e76\u91c7\u53d6\u4e86\u5305\u62ec\u51cf\u5c11\u4eba\u5458\u6210\u672c\u5728\u5185\u7684\u4e00\u7cfb\u5217\u6210\u672c\u63a7\u5236\u63aa\u65bd\u3002<\/p>\n<p><u>\u7ba1\u7406\u8d39\u7528<\/u><br \/>\u7ba1\u7406\u8d39\u7528\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u7684680\u4e07\u7f8e\u5143\u51cf\u5c11\u52302023\u5e746\u670830\u65e5\u7684450\u4e07\u7f8e\u5143\u3002\u7ba1\u7406\u8d39\u7528\u7684\u51cf\u5c11\u4e3b\u8981\u662f\u7531\u4e8e\u6210\u672c\u63a7\u5236\u5e26\u6765\u7684\u4eba\u5de5\u53ca\u529e\u516c\u6210\u672c\u7684\u51cf\u5c11\u3002<\/p>\n<p><u>\u5176\u4ed6\u8425\u4e1a\u6536\u5165<\/u><br \/>\u5176\u4ed6\u8425\u4e1a\u6536\u51652023\u5e746\u670830\u65e5\u7ea6340\u4e07\u7f8e\u5143\u3002\u5176\u4ed6\u8425\u4e1a\u6536\u5165\u5305\u542b\u4e86\u4ece\u4e00\u5bb6\u5408\u540c\u5236\u9020\u5546\u5904\u83b7\u5f97\u7684\uff0c\u9488\u5bf9\u516c\u53f8\u5728\u4e00\u4efd\u4e34\u5e8a\u524d\u9879\u76ee\u5916\u5305\u534f\u8bae\u4e2d\u4ea7\u751f\u7684\u635f\u5931\u7684\u4e00\u6b21\u6027\u8865\u507f\u6b3e\u3002<\/p>\n<p><u>\u51c0\u4e8f\u635f<\/u><br \/>\u51c0\u4e8f\u635f\u76f8\u8f83\u4e8e2022\u5e74\u540c\u671f\u76844,760\u4e07\u7f8e\u5143\u51cf\u5c11\u52302023\u5e746\u670830\u65e5\u7684410\u4e07\u7f8e\u5143\u3002<\/p>\n<p><u>\u6d41\u901a\u5728\u5916\u666e\u901a\u80a1<\/u><br \/>\u622a\u6b62\u81f32023\u5e746\u670830\u65e5\uff0c\u516c\u53f8\u6d41\u901a\u5728\u5916\u7684\u666e\u901a\u80a1\u4e3a54,793,339\u80a1\u3002\u6bcf\u4e00\u80a1\u7f8e\u56fd\u5b58\u6258\u80a1\u7968(ADS)\u53ef\u6362\u7b97\u4e3a1.25\u80a1\u666e\u901a\u80a1\u3002<\/p>\n<p><u>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219<\/u><u>\uff08<\/u><u>Non-GAAP\uff09<\/u><u>\u4e0b\u7684<\/u><u>\u4e8f\u635f<\/u><br \/>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5b9a\u4e49\u4e3a\u8be5\u671f\u95f4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5254\u9664\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u3002\u8be5\u91d1\u989d\u4ece2022\u5e74\u540c\u671f\u7684\u51c0\u4e8f\u635f4,190\u4e07\u7f8e\u5143\uff0c\u4e0b\u964d\u81f32023\u5e746\u670830\u65e5\u768410\u4e07\u7f8e\u5143\u3002\u8bf7\u53c2\u9605\u672c\u65b0\u95fb\u7a3f\u4e2d\u9898\u4e3a&quot;\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868&quot;\u90e8\u5206\u4e86\u89e3\u8be6\u60c5\u3002<\/p>\n<p>\u5929\u6f14\u836f\u4e1a\u4f7f\u7528Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u7528\u4e8e\u8bc4\u4f30\u672c\u516c\u53f8\u7684\u7ecf\u8425\u6210\u679c\uff0c\u4ee5\u53ca\u8d22\u52a1\u548c\u7ecf\u8425\u51b3\u7b56\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u6709\u52a9\u4e8e\u8bc6\u522b\u672c\u516c\u53f8\u4e1a\u52a1\u7684\u57fa\u672c\u8d8b\u52bf\uff0c\u800c\u8fd9\u4e9b\u8d8b\u52bf\u53ef\u80fd\u56e0\u672c\u516c\u53f8\u8ba1\u5165\u672c\u671f\u95f4\u4e8f\u635f\u7684\u67d0\u4e9b\u8d39\u7528\u7684\u5f71\u54cd\u800c\u626d\u66f2\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u63d0\u4f9b\u4e86\u6709\u5173\u5176\u7ecf\u8425\u6210\u679c\u7684\u6709\u7528\u4fe1\u606f\uff0c\u6574\u4f53\u63d0\u5347\u4e86\u5bf9\u5176\u8fc7\u53bb\u4e1a\u7ee9\u548c\u672a\u6765\u524d\u666f\u7684\u5168\u9762\u4e86\u89e3\uff0c\u5e76\u4f7f\u7ba1\u7406\u5c42\u5728\u8d22\u52a1\u548c\u8fd0\u8425\u51b3\u7b56\u4e2d\u4f7f\u7528\u7684\u5173\u952e\u6307\u6807\u66f4\u5177\u53ef\u89c1\u6027\u3002<\/p>\n<p>\u5bf9\u4e8e\u672c\u671f\u95f4\u7684Non-GAAP\u8d22\u52a1\u6307\u6807\u7684\u8861\u91cf\uff0c\u5929\u6f14\u836f\u4e1a\u4f7f\u7528\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u4e0d\u5e94\u5355\u72ec\u88ab\u8003\u8651\uff0c\u4e5f\u4e0d\u5e94\u88ab\u89c6\u4e3a\u8be5\u671f\u95f4\u8425\u4e1a\u5229\u6da6\u3001\u51c0\u4e8f\u635f\u6216\u4efb\u4f55\u5176\u4ed6\u4e1a\u7ee9\u8861\u91cf\u6307\u6807\u7684\u66ff\u4ee3\u54c1\uff0c\u6216\u4f5c\u4e3a\u5176\u7ecf\u8425\u4e1a\u7ee9\u7684\u8861\u91cf\u6307\u6807\u3002\u516c\u53f8\u9f13\u52b1\u6295\u8d44\u8005\u5ba1\u9605\u8be5\u671f\u95f4\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u5e76\u5ba1\u9605\u6700\u76f4\u63a5\u53ef\u6bd4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u8d22\u52a1\u6307\u6807\u7684\u8c03\u6574\u8fc7\u7a0b\u3002\u6b64\u5904\u6240\u5217\u671f\u95f4\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u53ef\u80fd\u65e0\u6cd5\u4e0e\u5176\u4ed6\u516c\u53f8\u63d0\u4f9b\u7684\u7c7b\u4f3c\u540d\u79f0\u7684\u8d22\u52a1\u6307\u6807\u76f8\u6bd4\u8f83\u3002\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u4f1a\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u8ba1\u7b97\u7c7b\u4f3c\u7684\u8d22\u52a1\u6307\u6807\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5b83\u4eec\u4f5c\u4e3a\u516c\u53f8\u53ef\u6bd4\u6570\u636e\u7684\u6709\u7528\u6027\u3002\u5929\u6f14\u836f\u4e1a\u9f13\u52b1\u6295\u8d44\u8005\u548c\u5176\u4ed6\u4eba\u5168\u9762\u5ba1\u9605\u672c\u516c\u53f8\u7684\u8d22\u52a1\u4fe1\u606f\uff0c\u800c\u4e0d\u662f\u4ec5\u4ec5\u5173\u6ce8\u4e8e\u5355\u4e00\u7684\u8d22\u52a1\u6307\u6807\u3002<\/p>\n<p>\u672c\u671f\u95f4\u8ba1\u7b97\u7684\u51c0\u5229\u6da6\u6307\u6807\u4e0bNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u4e0d\u5305\u62ec\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u3002\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u662f\u5411\u5458\u5de5\u6388\u4e88\u80a1\u7968\u6fc0\u52b1\u6240\u4ea7\u751f\u7684\u975e\u73b0\u91d1\u8d39\u7528\u3002\u6211\u4eec\u8ba4\u4e3a\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u7684\u8c03\u6574\u4fe1\u606f\u80fd\u5bf9\u7ba1\u7406\u5c42\u548c\u6295\u8d44\u4eba\u5728\u8fdb\u884c\u516c\u53f8\u8fd0\u8425\u8868\u73b0\u7684\u540c\u671f\u6bd4\u8f83\u4ee5\u53ca\u540c\u4e1a\u6bd4\u8f83\u65f6\u6709\u6240\u52a9\u76ca\u3002\u5176\u539f\u56e0\u6709\uff1a\uff08i\uff09\u5728\u67d0\u7279\u5b9a\u671f\u95f4\u5185\u7684\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u4e0e\u516c\u53f8\u7684\u8fd0\u8425\u8868\u73b0\u672a\u5fc5\u76f4\u63a5\u76f8\u5173\uff1b\uff08ii\uff09\u56e0\u516c\u53f8\u6388\u4e88\u65b0\u7684\u80a1\u6743\u6fc0\u52b1\u8ba1\u5212\u7684\u65f6\u95f4\u5b89\u6392\uff0c\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u5728\u4e0d\u540c\u671f\u95f4\u5185\u53ef\u80fd\u4f1a\u53d1\u751f\u8f83\u5927\u53d8\u5316\uff1b\u4ee5\u53ca\uff0c\uff08iii\uff09\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u91c7\u53d6\u4e0d\u540c\u7684\u80a1\u6743\u6fc0\u52b1\u5f62\u5f0f\u6216\u8005\u4f7f\u7528\u4e0d\u540c\u7684\u4f30\u503c\u65b9\u6cd5\u3002<\/p>\n<p>\u8bf7\u53c2\u9605\u672c\u516c\u544a\u7ed3\u5c3e\u7684 &quot;\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868&quot;\uff0c\u83b7\u53d6\u672c\u671f\u95f4Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u7684\u5b8c\u6574\u7684\u8c03\u6574\u8fc7\u7a0b\u3002<\/p>\n<p><b>\u5173\u4e8e\u5929\u6f14\u836f\u4e1a<\/b><\/p>\n<p>\u5929\u6f14\u836f\u4e1a\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u5e73\u53f0\u9a71\u52a8\u5e76\u62e5\u6709\u81ea\u4e3b\u5e73\u53f0\u4ea7\u51fa\u7684\u4e34\u5e8a\u4ea7\u54c1\u5f00\u53d1\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\u501f\u529b\u4e8e\u8ba1\u7b97\u751f\u7269\u5b66\u4e0e\u4eba\u5de5\u667a\u80fd\uff0c\u51ed\u501f\u5176\u5168\u7403\u9996\u521b\u7684\u4e09\u4f53\u5e73\u53f0\u6280\u672f\uff08\u65b0\u8868\u4f4d\u6297\u4f53NEObody&#x2122;\uff0c\u5b89\u5168\u6297\u4f53SAFEbody&reg;\u53ca\u5f3a\u529b\u6297\u4f53POWERbody&#x2122;\uff09\uff0c\u5929\u6f14\u836f\u4e1a\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u4e8e\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u72ec\u7279\u539f\u521b\u7684\u6297\u4f53\u4ea7\u54c1\u7ebf\uff0c\u4ee5\u89e3\u51b3\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u4e2a\u5168\u7403\u77e5\u540d\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5e76\u4ee5\u5176\u591a\u79cd\u539f\u521b\u524d\u6cbf\u79d1\u6280\u4e3a\u5408\u4f5c\u4f19\u4f34\u7684\u65b0\u836f\u7814\u53d1\u8d4b\u80fd\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1a&nbsp;<u><a href=\"https:\/\/investor.adagene.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/investor.adagene.com&nbsp;<\/a><\/u>\u5e76\u5173\u6ce8\u5929\u6f14\u836f\u4e1a<u><a href=\"https:\/\/t.prnasia.com\/t\/qgUNymgw\" target=\"_blank\" rel=\"nofollow noopener\">\u5fae\u4fe1<\/a><\/u>\u3001<u><a href=\"https:\/\/t.prnasia.com\/t\/QuTV1aBS\" target=\"_blank\" rel=\"nofollow noopener\">\u9886\u82f1<\/a><\/u>\u53ca<u><a href=\"https:\/\/t.prnasia.com\/t\/9qfrA1Nr\" target=\"_blank\" rel=\"nofollow noopener\">\u63a8\u7279<\/a><\/u>\u5b98\u65b9\u5e10\u53f7\u3002<\/p>\n<p>SAFEbody<sup>&reg;<\/sup> \u4e3a\u5929\u6f14\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b27\u76df\u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n<p><b>\u5b89\u5168\u6e2f\u58f0\u660e<\/b>&nbsp;<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u5173\u4e8e\u4e34\u5e8a\u6570\u636e\u5bf9\u60a3\u8005\u7684\u6f5c\u5728\u5f71\u54cd\u7684\u9648\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u7684\u63a8\u8fdb\u548c\u9884\u671f\u7684\u4e34\u5e8a\u524d\u6d3b\u52a8\u3001\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u4ee5\u53ca\u5176\u5019\u9009\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5929\u6f14\u836f\u4e1a\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u793a\u7684\u7ed3\u679c\u5b58\u5728\u91cd\u5927\u5dee\u5f02\uff1b\u5176\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u76d1\u7ba1\u6279\u51c6\uff1b\u76f8\u5173\u76d1\u7ba1\u673a\u6784\u5c31\u5929\u6f14\u836f\u4e1a\u5019\u9009\u836f\u7269\u7684\u76d1\u7ba1\u6279\u51c6\u505a\u51fa\u51b3\u5b9a\u7684\u5185\u5bb9\u548c\u65f6\u95f4\uff1b\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u5019\u9009\u836f\u7269\u53d6\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u6280\u672f\u548c\u836f\u7269\u83b7\u5f97\u548c\u7ef4\u6301\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u5236\u9020\u548c\u5176\u4ed6\u670d\u52a1\uff1b\u5929\u6f14\u836f\u4e1a\u6709\u9650\u7684\u7ecf\u8425\u5386\u53f2\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u83b7\u5f97\u989d\u5916\u8fd0\u8425\u8d44\u91d1\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u5728\u5176\u73b0\u6709\u6218\u7565\u4f19\u4f34\u5173\u7cfb\u6216\u5408\u4f5c\u4e4b\u5916\u7b7e\u8ba2\u989d\u5916\u5408\u4f5c\u534f\u8bae\u7684\u80fd\u529b\uff0c\u4ee5\u53caCOVID-19 \u6d41\u884c\u5bf9\u5929\u6f14\u836f\u4e1a\u4e34\u5e8a\u5f00\u53d1\u3001\u5546\u4e1a\u548c\u5176\u4ed6\u8fd0\u8425\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u63d0\u4ea4\u7ed9\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u768420-F\u5f62\u5f0f\u76842022\u5e74\u7684\u5e74\u5ea6\u62a5\u544a\u4e2d&quot;\u98ce\u9669\u56e0\u7d20&quot;\u90e8\u5206\u66f4\u5145\u5206\u8ba8\u8bba\u7684\u90a3\u4e9b\u98ce\u9669\u3002\u6240\u6709\u524d\u77bb\u6027\u9648\u8ff0\u5747\u57fa\u4e8e\u5929\u6f14\u836f\u4e1a\u5f53\u524d\u53ef\u83b7\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u4f9d\u7167\u6cd5\u5f8b\u4e4b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u836f\u4e1a\u4e0d\u627f\u62c5\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u5f00\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u7684\u4e49\u52a1\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prnpr2 prnpl2 prnvab prntac prnsbtb1 prnrbrb1 prnsbbb1 prnsblb1\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d22\u52a1\u62a5\u8868<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"4\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prnpr2 prnpl2 prnvab prntal prnsbtb1 prnrbrb1 prnsbbb1 prnsblb1\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u672a\u7ecf\u5ba1\u8ba1\u7684\u5408\u5e76\u8d44\u4ea7\u8d1f\u503a\u8868\uff08\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"4\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u622a\u6b62\u81f32022\u5e74<br \/>12\u670831\u65e5<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u622a\u6b62\u81f32023\u5e74<br \/>6\u670830\u65e5<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">US$<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">US$<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8d44\u4ea7<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u6d41\u52a8\u8d44\u4ea7:<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">143,758,678<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">128,759,962<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u6536\u5173\u8054\u65b9\u6b3e\u9879<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">619,432<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">393,969<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u6d41\u52a8\u8d44\u4ea7\u548c\u9884\u4ed8\u8d26\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">4,937,323<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">3,524,688<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u6d41\u52a8\u8d44\u4ea7\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>149,315,433<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>132,678,619<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u56fa\u5b9a\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2,782,963<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2,222,200<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4f7f\u7528\u6743\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">191,877<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">292,523<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52a8\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">109,572<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">108,922<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8d44\u4ea7\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>152,399,845<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>135,302,264<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">&nbsp;<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8d1f\u503a\u548c\u80a1\u4e1c\u6743\u76ca<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u6d41\u52a8\u8d1f\u503a:<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u8d26\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">3,666,124<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">4,483,776<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5408\u540c\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">15,107,276<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">812,916<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u5173\u8054\u65b9\u6b3e\u9879<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">19,323,337<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">17,216,032<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u9884\u63d0\u53ca\u5176\u4ed6\u6d41\u52a8\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">3,212,809<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2,834,565<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u6240\u5f97\u7a0e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">1,895,063<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u77ed\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">10,768,745<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">8,995,544<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5185\u5230\u671f\u7684\u957f\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2,850,128<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2,594,868<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5185\u5230\u671f\u7684\u79df\u8d41\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">151,983<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">158,859<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u6d41\u52a8\u8d1f\u503a\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>55,080,402<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>38,991,623<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u957f\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">14,146,541<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">13,348,003<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u79df\u8d41\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">53,834<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">141,431<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52a8\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">28,718<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">27,679<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8d1f\u503a\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>69,309,495<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>52,508,736<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">&nbsp;<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u80a1\u4e1c\u6743\u76ca:<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">5,497<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">5,556<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e93\u5b58\u80a1<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(4)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(4)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u8d44\u672c\u516c\u79ef<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">342,739,268<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">346,958,523<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u7efc\u5408\u4e8f\u635f<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(849,305)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,256,635)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7d2f\u8ba1\u4e8f\u635f<\/span><\/p>\n<\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(258,805,106)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(262,913,912)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>83,090,350<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>82,793,528<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8d1f\u503a\u548c\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>152,399,845<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>135,302,264<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen7\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u672a\u7ecf\u5ba1\u8ba1\u7684\u5408\u5e76\u5229\u6da6\u8868 <\/b>\uff08\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"3\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen5\" colspan=\"3\" rowspan=\"1\" nowrap>\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u622a\u81f3<\/span><\/b><b><span class=\"prnews_span\">6<\/span><\/b><b><span class=\"prnews_span\">\u670830\u65e5<\/span><\/b><b><span class=\"prnews_span\">\u7684<\/span><\/b><b><span class=\"prnews_span\">6\u4e2a\u6708<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen12\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2022<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen12\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen12\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2023<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u6536\u5165<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6280\u672f\u8bb8\u53ef\u5408\u4f5c<\/span><span class=\"prnews_span\">\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,923,174<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">17,295,745<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8d39\u7528<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7814\u53d1\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(45,148,357)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(21,289,434)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7ba1\u7406\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(6,848,925)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4,470,520)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8d39\u7528<\/span><\/b><b><span class=\"prnews_span\">\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(51,997,282)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(25,759,954)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u8425\u4e1a\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,415,230<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u8425\u4e1a\u4e8f\u635f<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(48,074,108)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(5,048,979)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">14,931<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,918,971<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(211,434)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(573,507)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">430,671<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,702,660<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6c47\u5151\u635f\u76ca<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">756,085<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,620,415<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u7a0e\u524d\u4e8f\u635f<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,083,855)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(1,795,670)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6240\u5f97\u7a0e\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(558,944)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(2,313,136)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u51c0\u4e8f\u635f<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(4,108,806)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u5176\u4ed6\u7efc\u5408\u6536\u76ca<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5916\u5e01\u62a5\u8868\u6298\u7b97\u5dee\u5f02<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">284,148<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(407,330)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u7efc\u5408\u4e8f\u635f\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen13\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,358,651)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen13\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(4,516,136)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u51c0\u4e8f\u635f<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(4,108,806)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u5f52\u5c5e\u4e8e\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen13\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen13\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(4,108,806)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u7528\u4e8e\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u635f\u5931\u7684\u52a0\u6743\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6570<\/span><\/b><b><span class=\"prnews_span\">:<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.87)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.08)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.87)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.08)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen7\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08<\/b><b>GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"3\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen5\" colspan=\"3\" rowspan=\"1\" nowrap>\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u622a\u81f3<\/span><\/b><b><span class=\"prnews_span\">6<\/span><\/b><b><span class=\"prnews_span\">\u670830\u65e5<\/span><\/b><b><span class=\"prnews_span\">\u7684<\/span><\/b><b><span class=\"prnews_span\">6\u4e2a\u6708<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">2022\u5e74<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">2023\u5e74<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">US$<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen16\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">US$<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u5f52\u5c5e\u4e8e\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(4,108,806)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8c03\u6574:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u6743\u6fc0\u52b1\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,725,868<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,030,214<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen13\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(41,916,931)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen13\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(78,592)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7528\u4e8e\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u635f\u5931\u7684\u52a0\u6743\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6570\uff1a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.77)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.00)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.77)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.00)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp; &nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211;\u6297CTLA-4\u5019\u9009\u6297\u4f53\u4ece\u8bbe\u8ba1\u4e0a\u63d0\u5347\u4e86\u6cbb\u7597\u6307\u657030\u500d\u4ee5\u4e0a\uff0c\u81f4\u529b\u4e8eCTLA-4\u4ecb\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u6e05\u9664\u4ee5\u8fdb\u4e00\u6b65\u63d0\u5347\u60a3\u8005\u7597\u6548\uff0c&nbsp;\u5177\u5907\u540c\u7c7b\u6700\u4f73\u6f5c\u529b &#8211;\u5b89\u5168\u6297\u4f53SAFEbody&reg; ADG126\u572810 mg\/kg\u5242\u91cf\u4e0b\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\uff0c\u9488\u5bf9\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u5355\u81c22\u671f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u5f3a\u70c8\u7684\u7597\u6548\u4fe1\u53f7 &#8211;\u6839\u636eSimon\u4e24\u9636\u6bb5\u76842\u671f\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u57fa\u4e8e10 mg\/kg\u5242\u91cf\u6bcf3\u5468\u4e00\u6b21\u7684\u7ed9\u836f\u9891\u7387\uff0c\u5b89\u5168\u6297\u4f53SAFEbody&reg; ADG126\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u9488\u5bf9\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u62d3\u5c55\u961f\u5217\u6b63\u5728\u5165\u7ec4\u7b2c\u4e8c\u9636\u6bb5\u768410\u4f8b\u60a3\u8005 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\u7597\u6cd5\u7684\u8fb9\u754c\uff0c\u81f4\u529b\u4e8e\u63d0\u9ad8\u764c\u75c7\u6cbb\u7597\u7684\u80fd\u529b\u5145\u6ee1\u4fe1\u5fc3\u3002&quot; \u6297CTLA-4\u9879\u76ee\u4eae\u70b9 1b\/2\u671f\u6570\u636e\u8868\u660e\uff0c\u9776\u5411\u72ec\u7279\u8868\u4f4d\u7684\u6297CTLA-4\u975e\u63a9\u853d\u578b\u65b0\u8868\u4f4d\u6297\u4f53NEObody&#x2122; ADG116\u5728\u5355\u4e00\u7597\u6cd5\u4ee5\u53ca\u4e0e\u6297PD-1\u7684\u8054\u5408\u7597\u6cd5\u4e2d\u5747\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u4e34\u5e8a\u7f13\u89e3\u3002 &nbsp; ADG116\u5355\u4e00\u7597\u6cd5\u5728\u6700\u9ad8\u5242\u91cf\u8fbe\u523015 mg\/kg\uff08N=59\uff09\u7684\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002 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mg\/kg\u4e14\u6bcf6\u5468\u7ed9\u836f\u4e00\u6b21\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u4e2d\uff0cADG116\u5c55\u73b0\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u4e0e\u4ee4\u4eba\u9f13\u821e\u7684\u6709\u6548\u6027\u3002\u6b63\u5728\u8fdb\u884c\u7684\u8054\u5408\u6cbb\u7597\u961f\u5217\u4e2d\u89c2\u5bdf\u5230\u4e34\u5e8a\u7f13\u89e3\uff0c\u5176\u4e2d\uff0c\u4e00\u4f4d\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u60a3\u8005\u5728\u5242\u91cf\u6c34\u5e73\u4e3a3 mg\/kg\uff08\u6700\u521d\u6bcf3\u5468\u7ed9\u836f\uff0c\u7136\u540e\u6bcf6\u5468\u7ed9\u836f\uff09\u7684ADG116\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u6301\u7eed\u8d85\u8fc7\u4e00\u5e74\u7684\u6301\u4e45\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff08ORR = 20%\uff1b1\/5\u53ef\u8bc4\u4f30\uff09\u3002 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