{"id":93574,"date":"2023-09-01T11:00:00","date_gmt":"2023-09-01T04:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023090111000093574"},"modified":"2023-09-01T19:44:57","modified_gmt":"2023-09-01T11:44:57","slug":"%e7%92%a7%e8%be%b0%e5%8c%bb%e8%8d%af%e5%ae%a3%e5%b8%83abm-1310%e5%9c%a8%e4%b8%ad%e5%9b%bd%e9%92%88%e5%af%b9%e5%8e%9f%e5%8f%91%e6%80%a7%e6%81%b6%e6%80%a7%e8%84%91%e8%82%bf%e7%98%a4%e7%9a%84i%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023090111000093574","title":{"rendered":"\u74a7\u8fb0\u533b\u836f\u5ba3\u5e03ABM-1310\u5728\u4e2d\u56fd\u9488\u5bf9\u539f\u53d1\u6027\u6076\u6027\u8111\u80bf\u7624\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9996\u4f8b\u75c5\u4eba\u6210\u529f\u7528\u836f"},"content":{"rendered":"

\u5723\u5730\u4e9a\u54e5\u548c\u4e0a\u6d77<\/span>2023\u5e749\u67081\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u74a7\u8fb0\u533b\u836f (ABM Therapeutics\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684BRAF \u6291\u5236\u5242ABM-1310\uff0c\u5728\u9488\u5bf9\u590d\u53d1\u548c\u8010\u836f\u7684\u539f\u53d1\u6027\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u4e8e\u8fd1\u65e5\u5728\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5929\u575b\u533b\u9662\u5b8c\u6210\u4e86\u9996\u4f8b\u60a3\u8005\u7684\u5165\u7ec4\u548c\u6210\u529f\u7ed9\u836f\u3002\u8fd9\u662fABM-1310\u5728\u4e2d\u56fd\u7684\u7b2c\u4e8c\u4e2a\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

ABM-1310\u662f\u74a7\u8fb0\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u4e2a\u53e3\u670d\u7684, \u5177\u6709\u9ad8\u9009\u62e9\u6027\u3001\u9ad8\u6c34\u6eb6\u6027\u3001\u4ee5\u53ca\u9ad8\u8840\u8111\u5c4f\u969c\u6e17\u900f\u6027\u7684\u5c0f\u5206\u5b50BRAF\u6291\u5236\u5242\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u52a8\u7269\u6a21\u578b\u4e2d\u5df2\u663e\u793a\u51fa\u8840\u8111\u5c4f\u969c\u6e17\u900f\u65b9\u9762\u7684\u72ec\u7279\u4f18\u52bf\u3002\u6b64\u524d\uff0cABM-1310\u5df2\u7ecf\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u591a\u5bb6\u4e2d\u5fc3\u5f00\u5c55\u4e86\u9488\u5bf9BRAF V600X\u7a81\u53d8\u665a\u671f\u5b9e\u4f53\u7624\u7684\u4e34\u5e8aI\u671f\u7814\u7a76\uff0c\u663e\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u8010\u53d7\u6027\u548c\u521d\u6b65\u6297\u80bf\u7624\u7597\u6548 \u3002\u90e8\u5206\u7814\u7a76\u7684\u9636\u6bb5\u6027\u6570\u636e\u6c47\u603b\u5df2\u57282023 ASCO\u5e74\u4f1a\u516c\u5f00\u53d1\u8868\uff08https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2023.41.16_suppl.3098\uff09<\/a>\u3002<\/p>\n

\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684ABM-1310\u9488\u5bf9\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6027\u3001 \u5242\u91cf\u9012\u589e\u548c\u6269\u5c55\u7684\u4e34\u5e8a\u7814\u7a76(NCT05892653)\uff0c\u65e8\u5728\u63a2\u7d22ABM-1310\u5728BRAF V600X\u7a81\u53d8\u590d\u53d1\u548c\u8010\u836f\u7684\u539f\u53d1\u6027\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u836f\u7269\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66, \u4ee5\u53ca\u521d\u6b65\u6297\u80bf\u7624\u7597\u6548\uff0c\u4e3aII\u671f\u4e34\u5e8a\u7814\u7a76\u53ca\u540e\u7eed\u7684\u4e34\u5e8a\u7814\u7a76\u786e\u5b9a\u6700\u4f73\u5242\u91cf\u3002\u672c\u9879\u76ee\u7ec4\u957f\u5355\u4f4d\u4e3a\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5929\u575b\u533b\u9662\uff0c\u4e3b\u8981\u7814\u7a76\u8005\u4e3a\u674e\u6587\u658c\u6559\u6388\u3002<\/p>\n

"\u539f\u53d1\u6027\u8111\u80bf\u7624\u6db5\u76d6100\u591a\u79cd\u4e0d\u540c\u7684\u4e9a\u578b\uff0c\u80bf\u7624\u79cd\u643a\u5e26BRAF V600X\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u662f\u5176\u4e2d\u4e00\u4e2a\u5e38\u89c1\u7684\u7fa4\u4f53\u3002\u5c3d\u7ba1\u8fd1\u5e74\u6765\u539f\u53d1\u6027\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u7684\u6cbb\u7597\u624b\u6bb5\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u5bf9\u4e8e\u590d\u53d1\u6216\u8010\u836f\u60a3\u8005\u6765\u8bf4\uff0c\u4ecd\u6709\u5f88\u5927\u7684\u4e34\u5e8a\u9700\u6c42\u672a\u5f97\u5230\u6ee1\u8db3"\uff0c\u74a7\u8fb0\u533b\u836f\u9996\u5e2d\u6267\u884c\u5b98\u9648\u6668\u535a\u58eb\u8bf4\uff0c"\u76ee\u524d\uff0cABM-1310\u6b63\u5728\u4e2d\u7f8e\u4e24\u56fd\u5f00\u5c553\u9879\u4e34\u5e8a\u7814\u7a76\u3002\u74a7\u8fb0\u56e2\u961f\u4f1a\u548c\u7814\u7a76\u4eba\u5458\u4ee5\u53ca\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u4e00\u8d77\uff0c\u81f4\u529b\u4e8e\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u548c\u60a3\u8005\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u5168\u529b\u63a8\u8fdbABM-1310\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u4ee5\u671f\u65e9\u65e5\u4e3a\u60a3\u8005\u548c\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u66f4\u52a0\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002"<\/p>\n

"\u7531\u4e8e\u5927\u591a\u6570\u539f\u53d1\u6076\u6027\u8111\u80bf\u7624\u9884\u540e\u5dee\uff0c\u73b0\u6709\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4e9f\u5f85\u63a2\u7d22\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002" ABM\u9996\u5e2d\u533b\u5b66\u5b98\u6768\u8d5e\u4e1c\u535a\u58eb\u8bf4\uff0c"\u57fa\u4e8e ABM-1310\u7684\u9ad8\u6c34\u6eb6\u6027\u3001\u7ec6\u80de\u548c\u8840\u8111\u5c4f\u969c\u901a\u900f\u6027\u7684\u72ec\u7279\u4f18\u52bf\uff0c\u6211\u4eec\u671f\u5f85ABM-1310\u5c06\u4e3aBRAF V600X \u7a81\u53d8\u9633\u6027\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u80bf\u7624\u60a3\u8005\u63d0\u4f9b\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9"\u3002<\/p>\n

\u76ee\u524d\uff0c\u74a7\u8fb0\u533b\u836f\u6b63\u5728\u8fdb\u884cB+\u8f6e\u878d\u8d44\u3002\u516c\u53f8\u671f\u5f85\u7740\u80fd\u4ece\u4e0d\u540c\u5c42\u9762\u548c\u7ef4\u5ea6\u540c\u56fd\u9645\u5236\u836f\u516c\u53f8\u3001\u56fd\u5185\u5916\u751f\u7269\u5236\u836f\u516c\u53f8\u4ee5\u53ca\u8bc1\u5238\u548c\u57fa\u91d1\u5f00\u5c55\u5e7f\u6cdb\u7684\u5408\u4f5c\uff0c\u529b\u4e89\u65e9\u65e5\u9020\u798f\u4e8e\u5168\u7403\u60a3\u8005\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5723\u5730\u4e9a\u54e5\u548c\u4e0a\u6d772023\u5e749\u67081\u65e5 \/\u7f8e\u901a\u793e\/ — \u74a7\u8fb0\u533b\u836f (ABM Therapeutics\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684BRAF \u6291\u5236\u5242ABM-1310\uff0c\u5728\u9488\u5bf9\u590d\u53d1\u548c\u8010\u836f\u7684\u539f\u53d1\u6027\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u4e8e\u8fd1\u65e5\u5728\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5929\u575b\u533b\u9662\u5b8c\u6210\u4e86\u9996\u4f8b\u60a3\u8005\u7684\u5165\u7ec4\u548c\u6210\u529f\u7ed9\u836f\u3002\u8fd9\u662fABM-1310\u5728\u4e2d\u56fd\u7684\u7b2c\u4e8c\u4e2a\u4e34\u5e8a\u7814\u7a76\u3002 ABM-1310\u662f\u74a7\u8fb0\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u4e2a\u53e3\u670d\u7684, \u5177\u6709\u9ad8\u9009\u62e9\u6027\u3001\u9ad8\u6c34\u6eb6\u6027\u3001\u4ee5\u53ca\u9ad8\u8840\u8111\u5c4f\u969c\u6e17\u900f\u6027\u7684\u5c0f\u5206\u5b50BRAF\u6291\u5236\u5242\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u52a8\u7269\u6a21\u578b\u4e2d\u5df2\u663e\u793a\u51fa\u8840\u8111\u5c4f\u969c\u6e17\u900f\u65b9\u9762\u7684\u72ec\u7279\u4f18\u52bf\u3002\u6b64\u524d\uff0cABM-1310\u5df2\u7ecf\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u591a\u5bb6\u4e2d\u5fc3\u5f00\u5c55\u4e86\u9488\u5bf9BRAF V600X\u7a81\u53d8\u665a\u671f\u5b9e\u4f53\u7624\u7684\u4e34\u5e8aI\u671f\u7814\u7a76\uff0c\u663e\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u8010\u53d7\u6027\u548c\u521d\u6b65\u6297\u80bf\u7624\u7597\u6548 \u3002\u90e8\u5206\u7814\u7a76\u7684\u9636\u6bb5\u6027\u6570\u636e\u6c47\u603b\u5df2\u57282023 ASCO\u5e74\u4f1a\u516c\u5f00\u53d1\u8868\uff08https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2023.41.16_suppl.3098\uff09\u3002 \u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684ABM-1310\u9488\u5bf9\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6027\u3001 \u5242\u91cf\u9012\u589e\u548c\u6269\u5c55\u7684\u4e34\u5e8a\u7814\u7a76(NCT05892653)\uff0c\u65e8\u5728\u63a2\u7d22ABM-1310\u5728BRAF V600X\u7a81\u53d8\u590d\u53d1\u548c\u8010\u836f\u7684\u539f\u53d1\u6027\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u836f\u7269\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66, \u4ee5\u53ca\u521d\u6b65\u6297\u80bf\u7624\u7597\u6548\uff0c\u4e3aII\u671f\u4e34\u5e8a\u7814\u7a76\u53ca\u540e\u7eed\u7684\u4e34\u5e8a\u7814\u7a76\u786e\u5b9a\u6700\u4f73\u5242\u91cf\u3002\u672c\u9879\u76ee\u7ec4\u957f\u5355\u4f4d\u4e3a\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5929\u575b\u533b\u9662\uff0c\u4e3b\u8981\u7814\u7a76\u8005\u4e3a\u674e\u6587\u658c\u6559\u6388\u3002 "\u539f\u53d1\u6027\u8111\u80bf\u7624\u6db5\u76d6100\u591a\u79cd\u4e0d\u540c\u7684\u4e9a\u578b\uff0c\u80bf\u7624\u79cd\u643a\u5e26BRAF V600X\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u662f\u5176\u4e2d\u4e00\u4e2a\u5e38\u89c1\u7684\u7fa4\u4f53\u3002\u5c3d\u7ba1\u8fd1\u5e74\u6765\u539f\u53d1\u6027\u6076\u6027\u8111\u80bf\u7624\u60a3\u8005\u7684\u6cbb\u7597\u624b\u6bb5\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u5bf9\u4e8e\u590d\u53d1\u6216\u8010\u836f\u60a3\u8005\u6765\u8bf4\uff0c\u4ecd\u6709\u5f88\u5927\u7684\u4e34\u5e8a\u9700\u6c42\u672a\u5f97\u5230\u6ee1\u8db3"\uff0c\u74a7\u8fb0\u533b\u836f\u9996\u5e2d\u6267\u884c\u5b98\u9648\u6668\u535a\u58eb\u8bf4\uff0c"\u76ee\u524d\uff0cABM-1310\u6b63\u5728\u4e2d\u7f8e\u4e24\u56fd\u5f00\u5c553\u9879\u4e34\u5e8a\u7814\u7a76\u3002\u74a7\u8fb0\u56e2\u961f\u4f1a\u548c\u7814\u7a76\u4eba\u5458\u4ee5\u53ca\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u4e00\u8d77\uff0c\u81f4\u529b\u4e8e\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u548c\u60a3\u8005\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u5168\u529b\u63a8\u8fdbABM-1310\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u4ee5\u671f\u65e9\u65e5\u4e3a\u60a3\u8005\u548c\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u66f4\u52a0\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002" "\u7531\u4e8e\u5927\u591a\u6570\u539f\u53d1\u6076\u6027\u8111\u80bf\u7624\u9884\u540e\u5dee\uff0c\u73b0\u6709\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4e9f\u5f85\u63a2\u7d22\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002" ABM\u9996\u5e2d\u533b\u5b66\u5b98\u6768\u8d5e\u4e1c\u535a\u58eb\u8bf4\uff0c"\u57fa\u4e8e ABM-1310\u7684\u9ad8\u6c34\u6eb6\u6027\u3001\u7ec6\u80de\u548c\u8840\u8111\u5c4f\u969c\u901a\u900f\u6027\u7684\u72ec\u7279\u4f18\u52bf\uff0c\u6211\u4eec\u671f\u5f85ABM-1310\u5c06\u4e3aBRAF V600X \u7a81\u53d8\u9633\u6027\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u80bf\u7624\u60a3\u8005\u63d0\u4f9b\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9"\u3002 \u76ee\u524d\uff0c\u74a7\u8fb0\u533b\u836f\u6b63\u5728\u8fdb\u884cB+\u8f6e\u878d\u8d44\u3002\u516c\u53f8\u671f\u5f85\u7740\u80fd\u4ece\u4e0d\u540c\u5c42\u9762\u548c\u7ef4\u5ea6\u540c\u56fd\u9645\u5236\u836f\u516c\u53f8\u3001\u56fd\u5185\u5916\u751f\u7269\u5236\u836f\u516c\u53f8\u4ee5\u53ca\u8bc1\u5238\u548c\u57fa\u91d1\u5f00\u5c55\u5e7f\u6cdb\u7684\u5408\u4f5c\uff0c\u529b\u4e89\u65e9\u65e5\u9020\u798f\u4e8e\u5168\u7403\u60a3\u8005\u3002… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-93574","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/93574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=93574"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/93574\/revisions"}],"predecessor-version":[{"id":93575,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/93574\/revisions\/93575"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=93574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=93574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=93574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}