{"id":93394,"date":"2023-08-31T10:10:00","date_gmt":"2023-08-31T03:10:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023083110100093394"},"modified":"2023-08-31T21:17:00","modified_gmt":"2023-08-31T13:17:00","slug":"sirnaomics%e5%ae%a3%e5%b8%83rnai%e7%96%97%e6%b3%95%e4%ba%a7%e5%93%81stp707-%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e5%a4%9a%e7%a7%8d%e5%ae%9e%e4%bd%93%e7%98%a4%e7%9a%84i%e6%9c%9f%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023083110100093394","title":{"rendered":"Sirnaomics\u5ba3\u5e03RNAi\u7597\u6cd5\u4ea7\u54c1STP707 \u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u6210\u529f"},"content":{"rendered":"<ul type=\"disc\">\n<li><i>\u516d\u4e2a\u961f\u5217\u5171<\/i><i>50<\/i><i>\u540d\u665a\u671f\u764c\u75c7\u60a3\u8005\u6bcf\u6708\u56db\u6b21\u91c7\u7528\u5242\u91cf\u722c\u5761\u65b9\u5f0f\u9759\u8109\u8f93\u6ce8<\/i><i>STP707<\/i><\/li>\n<li><i>\u6240\u6709\u7ec4\u522b\u5747\u663e\u793a\u51fa\u8f83\u5f3a\u7684\u5b89\u5168\u6027\uff0c\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u5242\u91cf\u7ec4\u51fa\u73b0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u53d7\u6cbb\u7597\u60a3\u8005\u663e\u793a\u51fa\u4ee4\u4eba\u632f\u594b\u7684\u7597\u6548\uff0c<\/i><i>74%<\/i><i>\u8bc4\u4f30\u53d7\u8bd5\u8005\u5b9e\u73b0\u75be\u75c5\u7a33\u5b9a\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u4e34\u5e8a\u7814\u7a76\u65f6\u95f4\u7ea6\u4e3a<\/i><i>77<\/i><i>\u5929<\/i><\/li>\n<\/ul>\n<p><p><span class=\"legendSpanClass\">\u9999\u6e2f\u3001\u9a6c\u91cc\u5170\u5dde\u5fb7\u56fd\u57ce\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e748\u670831\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;<b>Sirnaomics Ltd. <\/b>\uff08&quot;\u672c\u516c\u53f8&quot;\uff0c\u80a1\u4efd\u4ee3\u53f7\uff1a2257.HK\uff0c\u8fde\u540c\u5176\u9644\u5c5e\u516c\u53f8\uff0c\u7edf\u79f0&quot;\u672c\u96c6\u56e2&quot;\u6216&quot;Sirnaomics&quot;\uff09\uff0c\u4e00\u5bb6\u884c\u4e1a\u9886\u5148\u7684\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1RNAi\u7597\u6cd5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Sirnaomics \u516c\u5e03STP707\u7528\u4ee5\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624&nbsp;I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u6240\u6709\u5242\u91cf\u961f\u5217\u7ed9\u836f\uff0c\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u9488\u5bf9\u60a3\u6709\u5404\u7c7b\u665a\u671f\u5b9e\u4f53\u7624\u4e14\u5bf9\u6807\u51c6\u7597\u6cd5\u65e0\u53cd\u5e94\u7684\u60a3\u8005\u3002\u7ea674%\u7684\u53ef\u8bc4\u4f30\u60a3\u8005\u5448\u73b0\u51fa\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u6709\u6570\u540d\u60a3\u8005\u4f9d\u636e\u5b9e\u4f53\u7624\u6548\u5e94\u8bc4\u4ef7\u6807\u51c6\u5224\u5b9a\u4e3a\u80bf\u7624\u8d1f\u8377\u91cf\u51cf\u8f7b\u3002<\/p>\n<p><b>Sirnaomics<\/b><b>\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001\u6267\u884c\u8463\u4e8b\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u9646\u9633\u535a\u58eb<\/b>\u8868\u793a\uff1a&quot;\u8fd9\u662f&nbsp;RNAi \u764c\u75c7\u7597\u6cd5\u9886\u57df\u9996\u6b21\u6709&nbsp;I \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc1\u660e\u8be5\u7597\u6cd5\u5bf9\u8f6c\u79fb\u6027\u80bf\u7624\u5177\u6709\u5f88\u597d\u7684\u4e34\u5e8a\u6cbb\u7597\u6f5c\u529b\u3002\u6211\u4eec\u89c2\u5bdf\u5230\u60a3\u8005\u5728\u63a5\u53d7&nbsp;STP707 \u6cbb\u7597\u540e\u75be\u75c5\u7a33\u5b9a\uff0c\u751a\u81f3\u5176\u4e2d\u4e00\u4e9b\u60a3\u8005\u80bf\u7624\u4f53\u79ef\u7f29\u5c0f\u3002\u8fd9\u9879&nbsp;I \u671f\u7bee\u5f0f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u9f13\u52b1\u6211\u4eec\u8fdb\u884c\u6f5c\u5728\u7684\u5355\u836f\u7814\u7a76\u6216\u63a2\u7d22\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u836f\u7269\u8054\u5408\u7814\u7a76\u7684\u53ef\u80fd\u6027\u3002&quot;<\/p>\n<p>\u672c\u6b21\u7bee\u5f0f\u7814\u7a76\u603b\u5171\u62db\u52df\u4e8650\u540d\u80f0\u817a\u764c\u3001\u809d\u764c\u3001\u7ed3\u80a0\u764c\u53ca\u9ed1\u8272\u7d20\u7624\u7b49\u665a\u671f\u80bf\u7624\u60a3\u8005\uff0c\u5e76\u5bf9\u5148\u524d\u63a5\u53d7\u5df2\u4e0a\u5e02\u80bf\u7624\u836f\u7269\u7597\u6cd5\u540e\u4ecd\u7136\u51fa\u73b0\u75c5\u60c5\u6076\u5316\u3002\u6839\u636e\u521d\u6b65\u7597\u6548\u89c2\u5bdf\uff0c74%\u7684\u8bc4\u4f30\u53d7\u8bd5\u8005\u5b9e\u73b0\u75be\u75c5\u7a33\u5b9a\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u6709\u6570\u540d\u60a3\u8005\u7684\u80bf\u7624\u8d1f\u8377\u91cf\u51cf\u8f7b\u3002<\/p>\n<p>\u672c\u9879\u4e34\u5e8a\u7814\u7a76\u4e8e\u7f8e\u56fd\u591a\u5bb6\u9886\u5148\u80bf\u7624\u4e34\u5e8a\u673a\u6784\u53c2\u4e0e\uff0c\u5176\u4e2d\u5305\u62ec\u6885\u5965\u80bf\u7624\u8bca\u6240\uff08Mayo Clinic Oncology\uff09\u3001\u8036\u9c81\u5927\u5b66\u764c\u75c7\u4e2d\u5fc3\uff08Yale Cancer Center\uff09\u3001\u5948\u65af\u7279\u80bf\u7624\u6cbb\u7597\u4e2d\u5fc3\uff08Next Oncology\uff09\u3001\u57c3\u9ed8\u91cc\u764c\u75c7\u4e2d\u5fc3\uff08Emory Cancer Center\uff09\u548c\u5357\u52a0\u5dde\u5927\u5b66\u6d69\u683c\u533b\u9662\uff08University of <span class=\"xn-location\">Southern California<\/span>\/Hoag\uff09\u7b49\u3002\u8fd9\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u722c\u5761\u548c\u5242\u91cf\u6269\u5c55\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86STP707\u901a\u8fc7\u9759\u8109\u7ed9\u836f\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5171\u670950\u540d\u53d7\u8bd5\u8005\u53d7\u6ce83 \u6beb\u514b\u30016 \u6beb\u514b\u300112 \u6beb\u514b\u300124 \u6beb\u514b&nbsp;\u548c48 \u6beb\u514b\u4e0d\u540c\u5242\u91cf\u7684STP707\u8fdb\u884c\u6cbb\u7597\u3002\u53d7\u8bd5\u8005\u6bcf\u5468\u7528\u836f\u4e00\u6b21\uff0c\u5728\u4e3a\u671f28\u5929\u7684\u6cbb\u7597\u5468\u671f\u4e2d\u5171\u7528\u836f4\u6b21\u3002\u5982\u672a\u51fa\u73b0\u80bf\u7624\u6076\u5316\u60c5\u51b5\uff0c\u672a\u6765\u53d7\u8bd5\u8005\u5c06\u7ee7\u7eed\u53c2\u52a0\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5176\u6b21\u8981\u7ec8\u70b9\u662f\u786e\u5b9aSTP707\u7684\u836f\u4ee3\u836f\u52a8\u3001\u751f\u7269\u6807\u8bb0\u7269\u5e76\u89c2\u5bdf\u521d\u6b65\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728\u5b8c\u6210\u516d\u4e2a\u5242\u91cf\u961f\u5217\u5242\u91cf\u9650\u5236\u6bd2\u6027\u6240\u9700\u89c2\u5bdf\u671f\u540e\uff0c\u6bcf\u4e2a\u961f\u5217\u5747\u6ca1\u6709\u8868\u73b0\u51fa\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u6570\u636e\u5b89\u5168\u59d4\u5458\u4f1a\u5efa\u8bae\u8fdb\u884c\u5242\u91cf\u722c\u5761\u3002\u66f4\u591a\u4e34\u5e8a\u6570\u636e\u5c06\u5728\u5b8c\u6210\u6240\u6709\u6b63\u5728\u8fdb\u884c\u7684\u6cbb\u7597\u548c\u89c2\u5bdf\u540e\u63ed\u6653\u3002<\/p>\n<p>&quot;\u8fc4\u4eca\u4e3a\u6b62\uff0c\u4e0e\u5176\u4ed6\u521b\u65b0\u80bf\u7624\u6cbb\u7597\u836f\u7269\u76f8\u6bd4\uff0cSTP707\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u5b89\u5168\u6027\u3002\u53d7\u6cbb\u7597\u60a3\u8005\u663e\u793a\u51fa\u4ee4\u4eba\u632f\u594b\u7684\u7597\u6548\uff0c\u7ea674%\u8bc4\u4f30\u53d7\u8bd5\u8005\u5b9e\u73b0\u75be\u75c5\u7a33\u5b9a\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u6709\u6570\u540d\u60a3\u8005\u7684\u80bf\u7624\u8d1f\u8377\u91cf\u51cf\u8f7b\uff0c&quot;<b>Sirnaomics<\/b><b>\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u52a1\u5b98<\/b><b><span class=\"xn-person\">Michael Molyneaux<\/span><\/b><b>\u535a\u58eb<\/b>\u8bf4\u9053\uff0c&quot;\u9700\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u4e2d\u7684\u53d7\u8bd5\u8005\u4e4b\u524d\u63a5\u53d7\u8fc7\u591a\u79cd\u5f62\u5f0f\u7684\u6cbb\u7597\uff0c\u5305\u62ec\u624b\u672f\u3001\u653e\u5c04\u6cbb\u7597\u4ee5\u53ca\u9488\u5bf9\u7279\u5b9a\u80bf\u7624\u7684\u4e00\u7ebf\u548c\u4e8c\u7ebf\u7597\u6cd5\u3002\u6240\u6709\u53d7\u8bd5\u8005\u5728\u4e4b\u524d\u7684\u6cbb\u7597\u65b9\u6848\u4e2d\u90fd\u51fa\u73b0\u4e86\u6076\u5316\uff0c\u56e0\u6b64\u8fd9\u7ec4\u53d7\u8bd5\u8005\u4ee3\u8868\u4e86\u5bf9\u4e4b\u524d\u6240\u6709\u7597\u6cd5\u5747\u65e0\u53cd\u5e94\u7684\u8010\u836f\u80bf\u7624\u7c7b\u578b\u3002\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u5728\u8fd9\u7c7b\u8010\u836f\u80bf\u7624\u7c7b\u578b\u4e2d\uff0c\u6211\u4eec\u770b\u5230\u4e86\u975e\u5e38\u597d\u7684\u5b89\u5168\u6027\u548c\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\uff0c\u6211\u4eec\u671f\u5f85\u7740\u7ee7\u7eed\u8fd9\u9879\u7814\u7a76\u3002&quot;<\/p>\n<p>\u5982\u6b32\u4e86\u89e3\u6709\u5173Sirnaomics\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5176\u4ed6\u76f8\u5173\u4fe1\u606f\uff0c\u8bf7\u6d4f\u89c8<a href=\"http:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"nofollow noopener\">clinicaltrials.gov<\/a>\uff0c\u8bc6\u522b\u7801\uff1aNCT05037149\uff0c\u548c\u516c\u53f8\u7f51\u7ad9&nbsp;<a href=\"http:\/\/www.sirnaomics.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.sirnaomics.com<\/a>\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><\/b><b><u>STP707<\/u><\/b><\/p>\n<p>STP707\u7531\u9776\u5411TGF-\u03b21\u548cCOX-2 mRNA\u7684\u4e24\u4e2asiRNA\u5be1\u6838\u82f7\u9178\u7ec4\u6210\uff0c\u5e76\u4e0e\u7ec4\u6c28\u9178-\u8d56\u6c28\u9178\u5171\u805a\u80bd\uff08HKP+H\uff09\u7684\u8f7d\u4f53\u7ed3\u5408\u914d\u5236\u6210\u7eb3\u7c73\u9897\u7c92\u5236\u5242\u3002\u8fd9\u79cd\u7279\u5b9a\u7684\u591a\u80bd\u8f7d\u4f53\u4e0eSTP705\u6240\u7528\u7684\u8f7d\u4f53\u4e0d\u540c\u3002\u6bcf\u4e2a\u5355\u72ec\u7684siRNA\u90fd\u5177\u5907\u6291\u5236\u76f8\u5e94\u9776\u70b9mRNA\u8868\u8fbe\u7684\u80fd\u529b\u3002\u800cSTP707\u53ef\u540c\u65f6\u6291\u5236TGF-\u03b21\u548cCOX-2\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4ea7\u751f\u534f\u540c\u6548\u5e94\uff0c\u51cf\u5c11\u708e\u75c7\u53cd\u5e94\u3002\u4e14TGF-\u03b21\u548cCOX-2\u7684\u8fc7\u5ea6\u8868\u8fbe\u5df2\u88ab\u8bc1\u5b9e\u5728\u80bf\u7624\u5f62\u6210\u4e2d\u8d77\u7740\u5173\u952e\u7684\u8c03\u8282\u4f5c\u7528\u3002\u5728STP707\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u540e\u53ef\u89c2\u5bdf\u5230\u5305\u62ec\u809d\u810f\u3001\u80ba\u548c\u5f02\u79cd\u79fb\u690d\u7624\u7b49\u5668\u5b98\u4e2d\u7684TGF-\u03b21\u548cCOX-2\u57fa\u56e0\u8868\u8fbe\u88ab\u6572\u4f4e\u3002\u6b64\u5916\uff0c\u5728\u591a\u4e2a\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0cSTP707\u663e\u793a\u51fa\u5bf9\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u7c7b\u578b\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728\u5c0f\u9f20\u539f\u4f4d\u809d\u764c\u6a21\u578b\u4e2d\uff0cSTP707\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6297\u4f53\u8054\u7528\uff0c\u5177\u6709\u534f\u540c\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><\/b><b><u>Sirnaomics Ltd. (<\/u><\/b><b><u>\u80a1\u4efd\u4ee3\u53f7<\/u><\/b><b><u>: 2257)<\/u><\/b><\/p>\n<p>Sirnaomics\u662f\u4e00\u5bb6RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u5019\u9009\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u53ca\u4e34\u5e8a\u524d\u9636\u6bb5\uff0c\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1\u521b\u65b0\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5177\u6709\u533b\u7597\u9700\u6c42\u53ca\u5e9e\u5927\u5e02\u573a\u673a\u4f1a\u7684\u9002\u5e94\u75c7\u3002Sirnaomics\u662f\u9996\u5bb6\u4e8e\u4e9a\u6d32\u548c\u7f8e\u56fd\u5747\u62e5\u6709\u91cd\u8981\u5e02\u573a\u5730\u4f4d\u7684\u4e34\u5e8a\u9636\u6bb5RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u51ed\u501f\u5176\u4e13\u6709\u7684\u9012\u9001\u6280\u672f\uff1a\u591a\u80bd\u7eb3\u7c73\u9897\u7c92\u9012\u9001\u5e73\u53f0\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u8054\u7269\u9012\u9001\u5e73\u53f0\uff0c\u672c\u96c6\u56e2\u5df2\u5efa\u7acb\u975e\u5e38\u4e30\u5bcc\u7684\u5019\u9009\u836f\u7269\u7ba1\u7ebf\u3002\u968f\u7740\u516c\u53f8STP705\u548cSTP707\u7684\u4e34\u5e8a\u9879\u76ee\u53d6\u5f97\u591a\u9879\u6210\u529f\uff0cSirnaomics\u76ee\u524d\u5728\u63a8\u8fdb\u80bf\u7624\u6cbb\u7597\u7684RNAi\u836f\u7269\u65b9\u9762\u5904\u4e8e\u56fd\u9645\u9886\u5148\u5730\u4f4d\u3002STP122G\u662f\u9996\u6b3e\u8fdb\u5165\u4e34\u5e8a\u7814\u53d1\u9636\u6bb5\u7684GalAhead&#x2122;\u6280\u672f\u5019\u9009\u836f\u7269\u3002\u968f\u7740Sirnaomics\u4e34\u5e8a\u751f\u4ea7\u8bbe\u65bd\u7684\u5efa\u7acb\uff0c\u672c\u96c6\u56e2\u76ee\u524d\u6b63\u5728\u5b9e\u73b0\u4ece\u751f\u7269\u79d1\u6280\u516c\u53f8\u5411\u751f\u7269\u5236\u836f\u516c\u53f8\u7684\u8dc3\u8fdb\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u516c\u53f8\u8d44\u8baf\uff0c\u53ef\u6d4f\u89c8\uff1a<a href=\"http:\/\/www.sirnaomics.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.sirnaomics.com<\/a>\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u516d\u4e2a\u961f\u5217\u517150\u540d\u665a\u671f\u764c\u75c7\u60a3\u8005\u6bcf\u6708\u56db\u6b21\u91c7\u7528\u5242\u91cf\u722c\u5761\u65b9\u5f0f\u9759\u8109\u8f93\u6ce8STP707 \u6240\u6709\u7ec4\u522b\u5747\u663e\u793a\u51fa\u8f83\u5f3a\u7684\u5b89\u5168\u6027\uff0c\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u5242\u91cf\u7ec4\u51fa\u73b0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u53d7\u6cbb\u7597\u60a3\u8005\u663e\u793a\u51fa\u4ee4\u4eba\u632f\u594b\u7684\u7597\u6548\uff0c74%\u8bc4\u4f30\u53d7\u8bd5\u8005\u5b9e\u73b0\u75be\u75c5\u7a33\u5b9a\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u4e34\u5e8a\u7814\u7a76\u65f6\u95f4\u7ea6\u4e3a77\u5929 \u9999\u6e2f\u3001\u9a6c\u91cc\u5170\u5dde\u5fb7\u56fd\u57ce\u548c\u4e2d\u56fd\u82cf\u5dde2023\u5e748\u670831\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;Sirnaomics Ltd. \uff08&quot;\u672c\u516c\u53f8&quot;\uff0c\u80a1\u4efd\u4ee3\u53f7\uff1a2257.HK\uff0c\u8fde\u540c\u5176\u9644\u5c5e\u516c\u53f8\uff0c\u7edf\u79f0&quot;\u672c\u96c6\u56e2&quot;\u6216&quot;Sirnaomics&quot;\uff09\uff0c\u4e00\u5bb6\u884c\u4e1a\u9886\u5148\u7684\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1RNAi\u7597\u6cd5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Sirnaomics \u516c\u5e03STP707\u7528\u4ee5\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624&nbsp;I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u6240\u6709\u5242\u91cf\u961f\u5217\u7ed9\u836f\uff0c\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u9488\u5bf9\u60a3\u6709\u5404\u7c7b\u665a\u671f\u5b9e\u4f53\u7624\u4e14\u5bf9\u6807\u51c6\u7597\u6cd5\u65e0\u53cd\u5e94\u7684\u60a3\u8005\u3002\u7ea674%\u7684\u53ef\u8bc4\u4f30\u60a3\u8005\u5448\u73b0\u51fa\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u6709\u6570\u540d\u60a3\u8005\u4f9d\u636e\u5b9e\u4f53\u7624\u6548\u5e94\u8bc4\u4ef7\u6807\u51c6\u5224\u5b9a\u4e3a\u80bf\u7624\u8d1f\u8377\u91cf\u51cf\u8f7b\u3002 Sirnaomics\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001\u6267\u884c\u8463\u4e8b\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u9646\u9633\u535a\u58eb\u8868\u793a\uff1a&quot;\u8fd9\u662f&nbsp;RNAi \u764c\u75c7\u7597\u6cd5\u9886\u57df\u9996\u6b21\u6709&nbsp;I \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc1\u660e\u8be5\u7597\u6cd5\u5bf9\u8f6c\u79fb\u6027\u80bf\u7624\u5177\u6709\u5f88\u597d\u7684\u4e34\u5e8a\u6cbb\u7597\u6f5c\u529b\u3002\u6211\u4eec\u89c2\u5bdf\u5230\u60a3\u8005\u5728\u63a5\u53d7&nbsp;STP707 \u6cbb\u7597\u540e\u75be\u75c5\u7a33\u5b9a\uff0c\u751a\u81f3\u5176\u4e2d\u4e00\u4e9b\u60a3\u8005\u80bf\u7624\u4f53\u79ef\u7f29\u5c0f\u3002\u8fd9\u9879&nbsp;I \u671f\u7bee\u5f0f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u9f13\u52b1\u6211\u4eec\u8fdb\u884c\u6f5c\u5728\u7684\u5355\u836f\u7814\u7a76\u6216\u63a2\u7d22\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u836f\u7269\u8054\u5408\u7814\u7a76\u7684\u53ef\u80fd\u6027\u3002&quot; \u672c\u6b21\u7bee\u5f0f\u7814\u7a76\u603b\u5171\u62db\u52df\u4e8650\u540d\u80f0\u817a\u764c\u3001\u809d\u764c\u3001\u7ed3\u80a0\u764c\u53ca\u9ed1\u8272\u7d20\u7624\u7b49\u665a\u671f\u80bf\u7624\u60a3\u8005\uff0c\u5e76\u5bf9\u5148\u524d\u63a5\u53d7\u5df2\u4e0a\u5e02\u80bf\u7624\u836f\u7269\u7597\u6cd5\u540e\u4ecd\u7136\u51fa\u73b0\u75c5\u60c5\u6076\u5316\u3002\u6839\u636e\u521d\u6b65\u7597\u6548\u89c2\u5bdf\uff0c74%\u7684\u8bc4\u4f30\u53d7\u8bd5\u8005\u5b9e\u73b0\u75be\u75c5\u7a33\u5b9a\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u6709\u6570\u540d\u60a3\u8005\u7684\u80bf\u7624\u8d1f\u8377\u91cf\u51cf\u8f7b\u3002 \u672c\u9879\u4e34\u5e8a\u7814\u7a76\u4e8e\u7f8e\u56fd\u591a\u5bb6\u9886\u5148\u80bf\u7624\u4e34\u5e8a\u673a\u6784\u53c2\u4e0e\uff0c\u5176\u4e2d\u5305\u62ec\u6885\u5965\u80bf\u7624\u8bca\u6240\uff08Mayo Clinic Oncology\uff09\u3001\u8036\u9c81\u5927\u5b66\u764c\u75c7\u4e2d\u5fc3\uff08Yale Cancer Center\uff09\u3001\u5948\u65af\u7279\u80bf\u7624\u6cbb\u7597\u4e2d\u5fc3\uff08Next Oncology\uff09\u3001\u57c3\u9ed8\u91cc\u764c\u75c7\u4e2d\u5fc3\uff08Emory Cancer Center\uff09\u548c\u5357\u52a0\u5dde\u5927\u5b66\u6d69\u683c\u533b\u9662\uff08University of Southern California\/Hoag\uff09\u7b49\u3002\u8fd9\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u722c\u5761\u548c\u5242\u91cf\u6269\u5c55\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86STP707\u901a\u8fc7\u9759\u8109\u7ed9\u836f\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5171\u670950\u540d\u53d7\u8bd5\u8005\u53d7\u6ce83 \u6beb\u514b\u30016 \u6beb\u514b\u300112 \u6beb\u514b\u300124 \u6beb\u514b&nbsp;\u548c48 \u6beb\u514b\u4e0d\u540c\u5242\u91cf\u7684STP707\u8fdb\u884c\u6cbb\u7597\u3002\u53d7\u8bd5\u8005\u6bcf\u5468\u7528\u836f\u4e00\u6b21\uff0c\u5728\u4e3a\u671f28\u5929\u7684\u6cbb\u7597\u5468\u671f\u4e2d\u5171\u7528\u836f4\u6b21\u3002\u5982\u672a\u51fa\u73b0\u80bf\u7624\u6076\u5316\u60c5\u51b5\uff0c\u672a\u6765\u53d7\u8bd5\u8005\u5c06\u7ee7\u7eed\u53c2\u52a0\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5176\u6b21\u8981\u7ec8\u70b9\u662f\u786e\u5b9aSTP707\u7684\u836f\u4ee3\u836f\u52a8\u3001\u751f\u7269\u6807\u8bb0\u7269\u5e76\u89c2\u5bdf\u521d\u6b65\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728\u5b8c\u6210\u516d\u4e2a\u5242\u91cf\u961f\u5217\u5242\u91cf\u9650\u5236\u6bd2\u6027\u6240\u9700\u89c2\u5bdf\u671f\u540e\uff0c\u6bcf\u4e2a\u961f\u5217\u5747\u6ca1\u6709\u8868\u73b0\u51fa\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u6570\u636e\u5b89\u5168\u59d4\u5458\u4f1a\u5efa\u8bae\u8fdb\u884c\u5242\u91cf\u722c\u5761\u3002\u66f4\u591a\u4e34\u5e8a\u6570\u636e\u5c06\u5728\u5b8c\u6210\u6240\u6709\u6b63\u5728\u8fdb\u884c\u7684\u6cbb\u7597\u548c\u89c2\u5bdf\u540e\u63ed\u6653\u3002 &quot;\u8fc4\u4eca\u4e3a\u6b62\uff0c\u4e0e\u5176\u4ed6\u521b\u65b0\u80bf\u7624\u6cbb\u7597\u836f\u7269\u76f8\u6bd4\uff0cSTP707\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u5b89\u5168\u6027\u3002\u53d7\u6cbb\u7597\u60a3\u8005\u663e\u793a\u51fa\u4ee4\u4eba\u632f\u594b\u7684\u7597\u6548\uff0c\u7ea674%\u8bc4\u4f30\u53d7\u8bd5\u8005\u5b9e\u73b0\u75be\u75c5\u7a33\u5b9a\u7684\u6700\u4f73\u53cd\u5e94\uff0c\u6709\u6570\u540d\u60a3\u8005\u7684\u80bf\u7624\u8d1f\u8377\u91cf\u51cf\u8f7b\uff0c&quot;Sirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u52a1\u5b98Michael Molyneaux\u535a\u58eb\u8bf4\u9053\uff0c&quot;\u9700\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u4e2d\u7684\u53d7\u8bd5\u8005\u4e4b\u524d\u63a5\u53d7\u8fc7\u591a\u79cd\u5f62\u5f0f\u7684\u6cbb\u7597\uff0c\u5305\u62ec\u624b\u672f\u3001\u653e\u5c04\u6cbb\u7597\u4ee5\u53ca\u9488\u5bf9\u7279\u5b9a\u80bf\u7624\u7684\u4e00\u7ebf\u548c\u4e8c\u7ebf\u7597\u6cd5\u3002\u6240\u6709\u53d7\u8bd5\u8005\u5728\u4e4b\u524d\u7684\u6cbb\u7597\u65b9\u6848\u4e2d\u90fd\u51fa\u73b0\u4e86\u6076\u5316\uff0c\u56e0\u6b64\u8fd9\u7ec4\u53d7\u8bd5\u8005\u4ee3\u8868\u4e86\u5bf9\u4e4b\u524d\u6240\u6709\u7597\u6cd5\u5747\u65e0\u53cd\u5e94\u7684\u8010\u836f\u80bf\u7624\u7c7b\u578b\u3002\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u5728\u8fd9\u7c7b\u8010\u836f\u80bf\u7624\u7c7b\u578b\u4e2d\uff0c\u6211\u4eec\u770b\u5230\u4e86\u975e\u5e38\u597d\u7684\u5b89\u5168\u6027\u548c\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\uff0c\u6211\u4eec\u671f\u5f85\u7740\u7ee7\u7eed\u8fd9\u9879\u7814\u7a76\u3002&quot; \u5982\u6b32\u4e86\u89e3\u6709\u5173Sirnaomics\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5176\u4ed6\u76f8\u5173\u4fe1\u606f\uff0c\u8bf7\u6d4f\u89c8clinicaltrials.gov\uff0c\u8bc6\u522b\u7801\uff1aNCT05037149\uff0c\u548c\u516c\u53f8\u7f51\u7ad9&nbsp;www.sirnaomics.com\u3002 \u5173\u4e8eSTP707 STP707\u7531\u9776\u5411TGF-\u03b21\u548cCOX-2 mRNA\u7684\u4e24\u4e2asiRNA\u5be1\u6838\u82f7\u9178\u7ec4\u6210\uff0c\u5e76\u4e0e\u7ec4\u6c28\u9178-\u8d56\u6c28\u9178\u5171\u805a\u80bd\uff08HKP+H\uff09\u7684\u8f7d\u4f53\u7ed3\u5408\u914d\u5236\u6210\u7eb3\u7c73\u9897\u7c92\u5236\u5242\u3002\u8fd9\u79cd\u7279\u5b9a\u7684\u591a\u80bd\u8f7d\u4f53\u4e0eSTP705\u6240\u7528\u7684\u8f7d\u4f53\u4e0d\u540c\u3002\u6bcf\u4e2a\u5355\u72ec\u7684siRNA\u90fd\u5177\u5907\u6291\u5236\u76f8\u5e94\u9776\u70b9mRNA\u8868\u8fbe\u7684\u80fd\u529b\u3002\u800cSTP707\u53ef\u540c\u65f6\u6291\u5236TGF-\u03b21\u548cCOX-2\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4ea7\u751f\u534f\u540c\u6548\u5e94\uff0c\u51cf\u5c11\u708e\u75c7\u53cd\u5e94\u3002\u4e14TGF-\u03b21\u548cCOX-2\u7684\u8fc7\u5ea6\u8868\u8fbe\u5df2\u88ab\u8bc1\u5b9e\u5728\u80bf\u7624\u5f62\u6210\u4e2d\u8d77\u7740\u5173\u952e\u7684\u8c03\u8282\u4f5c\u7528\u3002\u5728STP707\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u540e\u53ef\u89c2\u5bdf\u5230\u5305\u62ec\u809d\u810f\u3001\u80ba\u548c\u5f02\u79cd\u79fb\u690d\u7624\u7b49\u5668\u5b98\u4e2d\u7684TGF-\u03b21\u548cCOX-2\u57fa\u56e0\u8868\u8fbe\u88ab\u6572\u4f4e\u3002\u6b64\u5916\uff0c\u5728\u591a\u4e2a\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0cSTP707\u663e\u793a\u51fa\u5bf9\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u7c7b\u578b\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728\u5c0f\u9f20\u539f\u4f4d\u809d\u764c\u6a21\u578b\u4e2d\uff0cSTP707\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6297\u4f53\u8054\u7528\uff0c\u5177\u6709\u534f\u540c\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u5173\u4e8eSirnaomics Ltd. (\u80a1\u4efd\u4ee3\u53f7: 2257) Sirnaomics\u662f\u4e00\u5bb6RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u5019\u9009\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u53ca\u4e34\u5e8a\u524d\u9636\u6bb5\uff0c\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1\u521b\u65b0\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5177\u6709\u533b\u7597\u9700\u6c42\u53ca\u5e9e\u5927\u5e02\u573a\u673a\u4f1a\u7684\u9002\u5e94\u75c7\u3002Sirnaomics\u662f\u9996\u5bb6\u4e8e\u4e9a\u6d32\u548c\u7f8e\u56fd\u5747\u62e5\u6709\u91cd\u8981\u5e02\u573a\u5730\u4f4d\u7684\u4e34\u5e8a\u9636\u6bb5RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u51ed\u501f\u5176\u4e13\u6709\u7684\u9012\u9001\u6280\u672f\uff1a\u591a\u80bd\u7eb3\u7c73\u9897\u7c92\u9012\u9001\u5e73\u53f0\u548c\u7b2c\u4e8c\u4ee3GalNAc\u5076\u8054\u7269\u9012\u9001\u5e73\u53f0\uff0c\u672c\u96c6\u56e2\u5df2\u5efa\u7acb\u975e\u5e38\u4e30\u5bcc\u7684\u5019\u9009\u836f\u7269\u7ba1\u7ebf\u3002\u968f\u7740\u516c\u53f8STP705\u548cSTP707\u7684\u4e34\u5e8a\u9879\u76ee\u53d6\u5f97\u591a\u9879\u6210\u529f\uff0cSirnaomics\u76ee\u524d\u5728\u63a8\u8fdb\u80bf\u7624\u6cbb\u7597\u7684RNAi\u836f\u7269\u65b9\u9762\u5904\u4e8e\u56fd\u9645\u9886\u5148\u5730\u4f4d\u3002STP122G\u662f\u9996\u6b3e\u8fdb\u5165\u4e34\u5e8a\u7814\u53d1\u9636\u6bb5\u7684GalAhead&#x2122;\u6280\u672f\u5019\u9009\u836f\u7269\u3002\u968f\u7740Sirnaomics\u4e34\u5e8a\u751f\u4ea7\u8bbe\u65bd\u7684\u5efa\u7acb\uff0c\u672c\u96c6\u56e2\u76ee\u524d\u6b63\u5728\u5b9e\u73b0\u4ece\u751f\u7269\u79d1\u6280\u516c\u53f8\u5411\u751f\u7269\u5236\u836f\u516c\u53f8\u7684\u8dc3\u8fdb\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u516c\u53f8\u8d44\u8baf\uff0c\u53ef\u6d4f\u89c8\uff1awww.sirnaomics.com\u3002 &nbsp;&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2023083110100093394\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-93394","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/93394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=93394"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/93394\/revisions"}],"predecessor-version":[{"id":93395,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/93394\/revisions\/93395"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=93394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=93394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=93394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}