{"id":92820,"date":"2023-08-25T07:00:00","date_gmt":"2023-08-25T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023082507000092820"},"modified":"2023-08-25T16:53:15","modified_gmt":"2023-08-25T08:53:15","slug":"%e6%9d%a5%e5%87%af%e5%8c%bb%e8%8d%af%e5%8f%91%e5%b8%832023%e5%b9%b4%e4%b8%ad%e6%9c%9f%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023082507000092820","title":{"rendered":"\u6765\u51ef\u533b\u836f\u53d1\u5e032023\u5e74\u4e2d\u671f\u4e1a\u7ee9"},"content":{"rendered":"<p class=\"prntac\"><b>AKT<\/b><b>\u6291\u5236\u5242<\/b><b>Afuresertib<\/b><b>\u4e34\u5e8a\u6709\u529b\u63a8\u8fdb<\/b>&nbsp;<b>\u81ea\u4e3b\u521b\u65b0\u539a\u79ef\u8584\u53d1<\/b><\/p>\n<ul type=\"disc\">\n<li>&nbsp;<i>\u5375\u5de2\u764c\u5173\u952e<\/i><i>II<\/i><i>\u671f\uff1a<\/i><i>Afuresertib(LAE002)<\/i><i>\u9488\u5bf9\u5375\u5de2\u764c\u5173\u952e<\/i><i>II<\/i><i>\u671f\u60a3\u8005\u5b8c\u6210\u5168\u90e8\u5165\u7ec4\uff0c\u9884\u8ba1\u5c06\u4e8e\u56db\u5b63\u5ea6\u672b\u83b7\u9876\u7ebf\u6570\u636e<\/i><\/li>\n<li>&nbsp;<i>\u4e73\u817a\u764c<\/i><i>Ib\/III<\/i><i>\u671f\uff1a<\/i><i>Afuresertib<\/i><i>\uff0b\u6c1f\u7ef4\u53f8\u7fa4\u6cbb\u7597<\/i><i>HR+\/HER2-<\/i><i>\u4e73\u817a\u764c<\/i><i>Ib<\/i><i>\u671f\u8bd5\u9a8c\u7684\u7814\u7a76\u7ed3\u679c\u5c06\u4e8e\u4eca\u5e74\u56db\u5b63\u5ea6\u516c\u5e03\u3002\u6b63\u4e0e\u76d1\u7ba1\u673a\u6784\u8ba8\u8bba\u542f\u52a8<\/i><i>III<\/i><i>\u671f\u5173\u952e\u8bd5\u9a8c<\/i><\/li>\n<li>&nbsp;<i>\u9996\u4e2a\u81ea\u7814\u6297\u4f53\uff1a<\/i><i>LAE102<\/i><i>\u4eca\u5e74<\/i>&nbsp;<i>5<\/i><i>\u6708\u83b7<\/i><i>FDA<\/i><i>\u7684<\/i><i>IND<\/i><i>\u6279\u51c6\uff0c\u5c06\u63a2\u7d22\u5728\u764c\u75c7\u3001\u80a5\u80d6\u548c\u4ee3\u8c22\u75be\u75c5\u3001\u80ba\u52a8\u8109\u9ad8\u538b\u7b49\u9002\u5e94\u75c7<\/i><\/li>\n<li>&nbsp;<i>\u6301\u7eed\u6295\u5165\u7814\u53d1\uff1a\u622a\u81f3<\/i><i>2023<\/i><i>\u5e74<\/i><i>6<\/i><i>\u6708<\/i><i>30<\/i><i>\u65e5\uff0c\u516c\u53f8\u7684\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u4e3a<\/i><i>8.37<\/i><i>\u4ebf\u5143\u4eba\u6c11\u5e01\uff0c\u4e0a\u534a\u5e74\u7814\u53d1\u6295\u5165\u8fbe<\/i><i>1.02<\/i><i>\u4ebf\u5143\u4eba\u6c11\u5e01<\/i><\/li>\n<\/ul>\n<p><p><span class=\"legendSpanClass\">\u4e2d\u56fd\u4e0a\u6d77\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u6c83\u4f26<\/span><span class=\"legendSpanClass\">2023\u5e748\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u6765\u51ef\u533b\u836f\uff08\u80a1\u4efd\u4ee3\u7801\uff1a2105.HK\uff09\uff0c\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u533b\u836f\u79d1\u6280\u516c\u53f8\uff0c\u4eca\u5929\u53d1\u5e03\u4e86\u622a\u81f32023\u5e746\u670830\u65e5\u7684\u4e2d\u671f\u4e1a\u7ee9\u516c\u544a\uff0c\u5c55\u793a\u5728\u4e34\u5e8a\u53ca\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u5f00\u53d1\u53ca\u4ea7\u54c1\u7ba1\u7ebf\u6269\u5927\u65b9\u9762\u53d6\u5f97\u7684\u91cd\u5927\u8fdb\u5c55\u3002<\/p>\n<p>\u6765\u51ef\u533b\u836f\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u5415\u5411\u9633\u535a\u58eb\u8868\u793a\uff1a&quot;2023\u4e0a\u534a\u5e74\u5bf9\u6211\u4eec\u6765\u8bf4\u6781\u5177\u91cc\u7a0b\u7891\u610f\u4e49\uff0c\u6765\u51ef\u533b\u836f\u6210\u4e3a\u4e86\u4e00\u5bb6\u4e0a\u5e02\u516c\u53f8\uff0c\u6211\u4eec\u7684\u521b\u65b0\u4ea7\u54c1\u7ba1\u7ebf\u83b7\u5f97\u4e86\u6295\u8d44\u8005\u53ca\u8d44\u672c\u5e02\u573a\u7684\u8ba4\u53ef\u3002<\/p>\n<p>2023\u5e74\u4e0b\u534a\u5e74\u4ee4\u4eba\u671f\u5f85\uff0c\u6765\u51ef\u9884\u8ba1\u5c06\u8fbe\u6210\u66f4\u591a\u7684\u91cc\u7a0b\u7891\u3002\u7279\u522b\u662f\u6211\u4eec\u5c06\u5728\u591a\u4e2a\u91cd\u8981\u5b66\u672f\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e00\u7cfb\u5217\u4e34\u5e8a\u76f8\u5173\u6570\u636e\uff0c\u5305\u62ecAKT\u6291\u5236\u5242Afuresertib\u5728\u6cbb\u7597\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u3001\u524d\u5217\u817a\u764c\u9886\u57df\u7684\u8fdb\u5c55\uff0c\u4ee5\u53ca\u591a\u4e2a\u81ea\u7814\u521b\u65b0\u6297\u4f53\u3002<\/p>\n<p>\u521b\u65b0\u4e3a\u5148\uff0c\u539a\u79ef\u8584\u53d1\u3002\u6211\u4eec\u6df1\u77e5\uff0c\u552f\u6709\u7ee7\u7eed\u8e0f\u5b9e\u5411\u524d\u3001\u575a\u6301\u4e0d\u61c8\uff0c\u65b9\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u5e0c\u671b\uff0c\u4e3a\u5e02\u573a\u521b\u9020\u4ef7\u503c\u3002&quot;<\/p>\n<p><b>\u4e1a\u52a1\u4eae\u70b9<\/b><\/p>\n<p><b>\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8fdb\uff1a<\/b><b>Afuresertib <\/b><b>\uff08<\/b><b>LAE002<\/b><b>\uff09\u6301\u7eed\u53d1\u529b<\/b><\/p>\n<ul type=\"disc\">\n<li><i>Afuresertib(LAE002)<\/i><i>\uff0b\u7d2b\u6749\u9187\u6cbb\u7597<\/i><i>PROC<\/i><i>\uff08<\/i><i>PROFECTOR-II<\/i><i>\uff09\uff0c\u5173\u952e<\/i><i>II<\/i><i>\u671f<br \/><\/i>\u60a3\u8005\u5df2\u5168\u90e8\u5165\u7ec4\uff0c\u9884\u8ba1\u5c06\u4e8e2023\u5e74\u7b2c\u56db\u5b63\u5ea6\u672b\u83b7\u5f97\u9876\u7ebf\u6570\u636e\u3002\u5982\u679c\u9876\u7ebf\u6570\u636e\u7b26\u5408\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u6807\u51c6\uff0c\u6211\u4eec\u5c06\u5206\u522b\u4e0e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u53ca\u4e2d\u56fd\u836f\u76d1\u5c40\u8ba8\u8bba\u5728\u7f8e\u56fd\u53ca\u4e2d\u56fd\u63d0\u4ea4NDA\u7684\u4e8b\u5b9c\u3002<\/li>\n<li><i>Afuresertib<\/i><i>\uff0b\u6c1f\u7ef4\u53f8\u7fa4\u6cbb\u7597<\/i><i>HR+\/HER2-<\/i><i>\u4e73\u817a\u764c<\/i><i>, Ib\/III<\/i><i>\u671f<br \/><\/i>Ib\u671f\u8bd5\u9a8c\u7684\u60a3\u8005\u5165\u7ec4\u5df2\u4e8e2023\u5e744\u6708\u5b8c\u6210\u3002\u8be5\u7814\u7a76\u53d6\u5f97\u4e86\u826f\u597d\u7684\u65e9\u671f\u6210\u679c\uff0c\u7814\u7a76\u7ed3\u679c\u5c06\u4e8e2023\u5e74\u7b2c\u56db\u5b63\u5ea6\u5728\u764c\u75c7\u5b66\u672f\u4f1a\u8bae\u4e0a\u516c\u5e03\u3002\u6211\u4eec\u76ee\u524d\u6b63\u5728\u4e0e\u76d1\u7ba1\u673a\u6784\u8ba8\u8bba\u542f\u52a8III\u671f\u5173\u952e\u8bd5\u9a8c\u3002<\/li>\n<li><i>Afuresertib<\/i><i>\uff0b<\/i><i>LAE001\/<\/i><i>\u6cfc\u5c3c\u677e\u6cbb\u7597<\/i><i>mCRPC,II<\/i><i>\u671f<br \/><\/i>\u5df2\u4e8e2023\u5e743\u6708\u5728\u7f8e\u56fd\u53ca\u97e9\u56fd\u5b8c\u6210\u60a3\u8005\u5165\u7ec4\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0c\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\u60a3\u8005\u6709\u671b\u83b7\u5f97\u826f\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002\u7814\u7a76\u7ed3\u679c\u5c06\u4e8e2023\u5e74ESMO\u4e0a\u516c\u5e03\u3002\u5176\u540e\u7684\u5173\u952e\u8bd5\u9a8c\u8bbe\u8ba1\u5c06\u4e0e\u76d1\u7ba1\u673a\u6784\u8fdb\u884c\u8ba8\u8bba\u3002<\/li>\n<li><i>Afuresertib<\/i><i>\uff0b<\/i><i>LAE005<\/i><i>\uff0b\u767d\u86cb\u767d\u7d2b\u6749\u9187\u6cbb\u7597<\/i><i>TNBC,I<\/i><i>\u671f<br \/><\/i>\u5b8c\u6210\u5242\u91cf\u9012\u589e\u9636\u6bb5\u8bd5\u9a8c\u5e76\u786e\u5b9a\u4e86II\u671f\u63a8\u8350\u5242\u91cf\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u60a3\u8005\u6709\u671b\u83b7\u5f97\u826f\u597d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u8be6\u7ec6\u7ed3\u679c\u5c06\u4e8e2023\u5e74CSCO\u5e74\u4f1a\u4e0a\u8fdb\u884c\u53e3\u5934\u62a5\u544a\u3002<\/li>\n<li><i>Afuresertib<\/i><i>\uff0b\u4fe1\u8fea\u5229\u5355\u6297\uff0b\u7d2b\u6749\u9187\u6cbb\u7597<\/i><i>EC<\/i><i>\u53ca<\/i><i>CC, I<\/i><i>\u671f<br \/><\/i>\u5df2\u5b8c\u6210\u56db\u4e2a\u961f\u5217\u4e2d\u7684\u4e09\u4e2a\u961f\u5217\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\uff0c\u5e76\u5728\u63a5\u53d71-3\u7ebf\u5316\u7597\u548c\/\u6216PD-1\u836f\u7269SOC\u6cbb\u7597\u540e\u7684\u5b50\u5bab\u9888\u764c\uff08<i>CC<\/i><i>\uff09<\/i><span>\u53ca\u5b50\u5bab\u5185\u819c\u764c\uff08EC\uff09\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u79ef\u6781\u7684\u7f13\u89e3\u7387\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u53d1\u73b0\uff1a\u81ea\u4e3b\u521b\u65b0\u539a\u79ef\u8584\u53d1<\/b><\/p>\n<ul type=\"disc\">\n<li><i>LAE102<\/i><i>\u7684<\/i><i>IND<\/i><i>\u6279\u51c6<br \/><\/i>LAE102\u662f\u6211\u4eec\u7684\u9996\u4e2a\u81ea\u4e3b\u7814\u53d1\u6297\u4f53\uff0c\u4e8e2023\u5e745\u6708\u83b7\u5f97FDA\u7684IND\u6279\u51c6\u3002\u6211\u4eec\u5c06\u9996\u5148\u7814\u7a76LAE102\u5728\u764c\u75c7\u9002\u5e94\u75c7\u4e2d\u7684\u5e94\u7528\uff0c\u540e\u671f\u5c06\u63a2\u7d22LAE102\u5728\u80a5\u80d6\u548c\u4ee3\u8c22\u75be\u75c5\u3001\u80ba\u52a8\u8109\u9ad8\u538b\u7b49\u5176\u4ed6\u75be\u75c5\u9002\u5e94\u75c7\u4e2d\u7684\u5e94\u7528\u3002<\/li>\n<li><i>\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269<\/i><i>(PCC)<\/i><i>\u7533\u62a5<br \/><\/i>\u6211\u4eec\u5df2\u63a8\u8fdb\u81ea\u4e3b\u7814\u53d1\u5e73\u53f0\u7684\u4e09\u4e2aPCC\u5019\u9009\u836f\u7269\uff1aLAE111\uff08\u4e00\u79cdLILRB1\u53caLILRB2\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\uff1bLAE113\uff08\u4e00\u79cdTIGIT-PVRIG\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\uff1b\u53caLAE112\uff08\u4e00\u79cdFGFR2b\u5355\u514b\u9686\u6297\u4f53\uff09\u3002<\/li>\n<\/ul>\n<p><b>\u5373\u5c06\u5230\u6765\u7684\u91cc\u7a0b\u7891<\/b><\/p>\n<ul type=\"disc\">\n<li><b>9<\/b><b>\u6708<\/b><b>CSCO 2023<\/b>\uff08\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff0c\u4e2d\u56fd\u53a6\u95e8\uff09&nbsp;\u53e3\u5934\u62a5\u544aAfuresertib\uff0bLAE005\uff0b\u767d\u86cb\u767d\u7d2b\u6749\u9187I\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c<\/li>\n<li><b>10<\/b><b>\u6708<\/b><b>ESMO 2023<\/b>\uff08\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff0c\u897f\u73ed\u7259\u9a6c\u5fb7\u91cc\uff09&nbsp;\u58c1\u62a5\u5f62\u5f0f\u5c55\u793aAfuresertib\uff0bLAE001 I\/II\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c<\/li>\n<li><b>11<\/b><b>\u6708<\/b><b>SITC<\/b>\uff08\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a<b>\u7b2c<\/b><b>38<\/b><b>\u5c4a\u5e74\u4f1a\uff0c<\/b>\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u5730\u4e9a\u54e5\uff09&nbsp;\u58c1\u62a5\u5f62\u5f0f\u5c55\u793aLAE111\/LILRB1\u20132\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u4ee5\u53caLAE113\/TIGIT\/PVRIG\u53cc\u7279\u5f02\u6027\u6297\u4f53<\/li>\n<li><b>\u56db\u5b63\u5ea6<\/b>&nbsp;\u516c\u5e03Afuresertib\uff0b\u6c1f\u7ef4\u53f8\u7fa4Ib\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c<\/li>\n<\/ul>\n<p><b>\u4e0a\u534a\u5e74\u8d22\u52a1\u6458\u8981<\/b><\/p>\n<p>\u622a\u81f32023\u5e746\u670830\u65e5\uff0c\u516c\u53f8\u7684\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u4e3a8.37\u4ebf\u5143\u4eba\u6c11\u5e01\uff0c\u603b\u8d44\u4ea7\u91d1\u989d\u7ea610.63\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u6211\u4eec\u6301\u7eed\u6295\u5165\u7814\u53d1\uff0c\u4e0a\u534a\u5e74\u7814\u53d1\u8d39\u7528\u7ea61.02\u4ebf\u5143\u4eba\u6c11\u5e01\u3002<\/p>\n<p><b>\u5173\u4e8e\u6765\u51ef\u533b\u836f<br \/><\/b>\u80a1\u4efd\u4ee3\u7801\uff1a2105.HK<\/p>\n<p>\u6765\u51ef\u533b\u836f\u6210\u7acb\u4e8e2016\u5e74\uff0c\u662f\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u533b\u836f\u79d1\u6280\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u764c\u75c7\u53ca\u809d\u7ea4\u7ef4\u5316\u60a3\u8005\u5e26\u6765\u65b0\u578b\u7597\u6cd5\u3002<\/p>\n<p>\u622a\u81f32023\u5e746\u670830\u65e5\uff0c\u6211\u4eec\u5df2\u9488\u5bf9Afuresertib (LAE002)\u3001LAE001\u53caLAE005\u542f\u52a8\u516d\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u9879\u5173\u952e\u8bd5\u9a8c\uff0c\u8986\u76d6\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u3001\u524d\u5217\u817a\u764c\u7b49\uff0c\u4ee5\u89e3\u51b3\u764c\u75c7\u9886\u57df\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u4e0a\u8ff0\u516d\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4e09\u9879\u662f\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c(MRCT)\u3002<\/p>\n<p>\u5728\u81ea\u4e3b\u7814\u53d1\u9886\u57df\uff0c\u6765\u51ef\u533b\u836f\u5185\u90e8\u5df2\u53d1\u73b0\u5341\u4e8c\u79cd\u5019\u9009\u836f\u7269\u3002LAE102\u662f\u6211\u4eec\u7684\u9996\u4e2a\u81ea\u4e3b\u7814\u53d1\u6297\u4f53\uff0c\u4e8e2023\u5e745\u6708\u83b7\u5f97FDA\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u6279\u51c6\u3002<\/p>\n<p>2023\u5e746\u670829\u65e5, \u6765\u51ef\u533b\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\uff08&quot;\u9999\u6e2f\u4ea4\u6613\u6240&quot;\uff09\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u4efd\u4ee3\u7801\uff1a2105.HK\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u516c\u53f8\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee <a href=\"http:\/\/www.laekna.com\/\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.laekna.com<\/a><\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6709\u82e5\u5e72\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u8be5\u7b49\u524d\u77bb\u6027\u9648\u8ff0\u5e76\u975e\u5386\u53f2\u4e8b\u5b9e\uff0c\u4e43\u57fa\u4e8e\u6765\u51ef\u533b\u836f\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u548c\u671f\u5f85\u800c\u5bf9\u672a\u6765\u4e8b\u4ef6\u505a\u51fa\u7684\u9884\u6d4b\uff0c\u901a\u5e38\u4f1a\u4f7f\u7528&quot;\u5c06&quot;\u3001&quot;\u53ef\u80fd&quot;\u3001&quot;\u671f\u671b&quot;\u3001&quot;\u76f8\u4fe1&quot;\u3001&quot;\u8ba1\u5212&quot;\u3001&quot;\u9884\u4f30&quot;\u3001&quot;\u9884\u6d4b&quot;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u3002\u5c3d\u7ba1\u672c\u516c\u53f8\u76f8\u4fe1\u6240\u505a\u7684\u9884\u6d4b\u5408\u7406\uff0c\u4f46\u662f\u57fa\u4e8e\u672a\u6765\u4e8b\u4ef6\u56fa\u6709\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u6d4b\u6709\u91cd\u5927\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u60a8\u5e94\u6ce8\u610f\uff0c\u4f9d\u8d56\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ef\u80fd\u5bfc\u81f4\u5df2\u77e5\u53ca\u672a\u77e5\u7684\u91cd\u5927\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u672c\u65b0\u95fb\u7a3f\u8f7d\u6709\u7684\u6240\u6709\u524d\u77bb\u6027\u9648\u8ff0\u9700\u53c2\u7167\u672c\u90e8\u5206\u6240\u5217\u7684\u63d0\u793a\u58f0\u660e\u3002\u672c\u65b0\u95fb\u7a3f\u6240\u8f7d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u4ee5\u622a\u81f3\u672c\u65b0\u95fb\u7a3f\u505a\u51fa\u5f53\u65e5\u4e3a\u51c6\uff0c\u4e14\u4ec5\u57fa\u4e8e\u5f53\u65e5\u7684\u5047\u8bbe\uff0c\u9664\u6cd5\u5f8b\u6709\u6240\u89c4\u5b9a\u5916\uff0c\u672c\u516c\u53f8\u6982\u4e0d\u627f\u62c5\u4e49\u52a1\u5bf9\u8be5\u7b49\u524d\u77bb\u6027\u9648\u8ff0\u66f4\u65b0\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AKT\u6291\u5236\u5242Afuresertib\u4e34\u5e8a\u6709\u529b\u63a8\u8fdb&nbsp;\u81ea\u4e3b\u521b\u65b0\u539a\u79ef\u8584\u53d1 &nbsp;\u5375\u5de2\u764c\u5173\u952eII\u671f\uff1aAfuresertib(LAE002)\u9488\u5bf9\u5375\u5de2\u764c\u5173\u952eII\u671f\u60a3\u8005\u5b8c\u6210\u5168\u90e8\u5165\u7ec4\uff0c\u9884\u8ba1\u5c06\u4e8e\u56db\u5b63\u5ea6\u672b\u83b7\u9876\u7ebf\u6570\u636e &nbsp;\u4e73\u817a\u764cIb\/III\u671f\uff1aAfuresertib\uff0b\u6c1f\u7ef4\u53f8\u7fa4\u6cbb\u7597HR+\/HER2-\u4e73\u817a\u764cIb\u671f\u8bd5\u9a8c\u7684\u7814\u7a76\u7ed3\u679c\u5c06\u4e8e\u4eca\u5e74\u56db\u5b63\u5ea6\u516c\u5e03\u3002\u6b63\u4e0e\u76d1\u7ba1\u673a\u6784\u8ba8\u8bba\u542f\u52a8III\u671f\u5173\u952e\u8bd5\u9a8c &nbsp;\u9996\u4e2a\u81ea\u7814\u6297\u4f53\uff1aLAE102\u4eca\u5e74&nbsp;5\u6708\u83b7FDA\u7684IND\u6279\u51c6\uff0c\u5c06\u63a2\u7d22\u5728\u764c\u75c7\u3001\u80a5\u80d6\u548c\u4ee3\u8c22\u75be\u75c5\u3001\u80ba\u52a8\u8109\u9ad8\u538b\u7b49\u9002\u5e94\u75c7 &nbsp;\u6301\u7eed\u6295\u5165\u7814\u53d1\uff1a\u622a\u81f32023\u5e746\u670830\u65e5\uff0c\u516c\u53f8\u7684\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u4e3a8.37\u4ebf\u5143\u4eba\u6c11\u5e01\uff0c\u4e0a\u534a\u5e74\u7814\u53d1\u6295\u5165\u8fbe1.02\u4ebf\u5143\u4eba\u6c11\u5e01 \u4e2d\u56fd\u4e0a\u6d77\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u6c83\u4f262023\u5e748\u670825\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u6765\u51ef\u533b\u836f\uff08\u80a1\u4efd\u4ee3\u7801\uff1a2105.HK\uff09\uff0c\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u533b\u836f\u79d1\u6280\u516c\u53f8\uff0c\u4eca\u5929\u53d1\u5e03\u4e86\u622a\u81f32023\u5e746\u670830\u65e5\u7684\u4e2d\u671f\u4e1a\u7ee9\u516c\u544a\uff0c\u5c55\u793a\u5728\u4e34\u5e8a\u53ca\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u5f00\u53d1\u53ca\u4ea7\u54c1\u7ba1\u7ebf\u6269\u5927\u65b9\u9762\u53d6\u5f97\u7684\u91cd\u5927\u8fdb\u5c55\u3002 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2023\u5e74\u4e0b\u534a\u5e74\u4ee4\u4eba\u671f\u5f85\uff0c\u6765\u51ef\u9884\u8ba1\u5c06\u8fbe\u6210\u66f4\u591a\u7684\u91cc\u7a0b\u7891\u3002\u7279\u522b\u662f\u6211\u4eec\u5c06\u5728\u591a\u4e2a\u91cd\u8981\u5b66\u672f\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e00\u7cfb\u5217\u4e34\u5e8a\u76f8\u5173\u6570\u636e\uff0c\u5305\u62ecAKT\u6291\u5236\u5242Afuresertib\u5728\u6cbb\u7597\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u3001\u524d\u5217\u817a\u764c\u9886\u57df\u7684\u8fdb\u5c55\uff0c\u4ee5\u53ca\u591a\u4e2a\u81ea\u7814\u521b\u65b0\u6297\u4f53\u3002 \u521b\u65b0\u4e3a\u5148\uff0c\u539a\u79ef\u8584\u53d1\u3002\u6211\u4eec\u6df1\u77e5\uff0c\u552f\u6709\u7ee7\u7eed\u8e0f\u5b9e\u5411\u524d\u3001\u575a\u6301\u4e0d\u61c8\uff0c\u65b9\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u5e0c\u671b\uff0c\u4e3a\u5e02\u573a\u521b\u9020\u4ef7\u503c\u3002&quot; \u4e1a\u52a1\u4eae\u70b9 \u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8fdb\uff1aAfuresertib \uff08LAE002\uff09\u6301\u7eed\u53d1\u529b Afuresertib(LAE002)\uff0b\u7d2b\u6749\u9187\u6cbb\u7597PROC\uff08PROFECTOR-II\uff09\uff0c\u5173\u952eII\u671f\u60a3\u8005\u5df2\u5168\u90e8\u5165\u7ec4\uff0c\u9884\u8ba1\u5c06\u4e8e2023\u5e74\u7b2c\u56db\u5b63\u5ea6\u672b\u83b7\u5f97\u9876\u7ebf\u6570\u636e\u3002\u5982\u679c\u9876\u7ebf\u6570\u636e\u7b26\u5408\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u6807\u51c6\uff0c\u6211\u4eec\u5c06\u5206\u522b\u4e0e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u53ca\u4e2d\u56fd\u836f\u76d1\u5c40\u8ba8\u8bba\u5728\u7f8e\u56fd\u53ca\u4e2d\u56fd\u63d0\u4ea4NDA\u7684\u4e8b\u5b9c\u3002 Afuresertib\uff0b\u6c1f\u7ef4\u53f8\u7fa4\u6cbb\u7597HR+\/HER2-\u4e73\u817a\u764c, Ib\/III\u671fIb\u671f\u8bd5\u9a8c\u7684\u60a3\u8005\u5165\u7ec4\u5df2\u4e8e2023\u5e744\u6708\u5b8c\u6210\u3002\u8be5\u7814\u7a76\u53d6\u5f97\u4e86\u826f\u597d\u7684\u65e9\u671f\u6210\u679c\uff0c\u7814\u7a76\u7ed3\u679c\u5c06\u4e8e2023\u5e74\u7b2c\u56db\u5b63\u5ea6\u5728\u764c\u75c7\u5b66\u672f\u4f1a\u8bae\u4e0a\u516c\u5e03\u3002\u6211\u4eec\u76ee\u524d\u6b63\u5728\u4e0e\u76d1\u7ba1\u673a\u6784\u8ba8\u8bba\u542f\u52a8III\u671f\u5173\u952e\u8bd5\u9a8c\u3002 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