{"id":92659,"date":"2023-08-24T08:22:00","date_gmt":"2023-08-24T01:22:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023082408220092659"},"modified":"2023-08-24T17:02:42","modified_gmt":"2023-08-24T09:02:42","slug":"%e5%ba%b7%e5%ae%81%e6%9d%b0%e7%91%9e%e5%85%ac%e5%b8%832023%e5%b9%b4%e5%ba%a6%e4%b8%8a%e5%8d%8a%e5%b9%b4%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023082408220092659","title":{"rendered":"\u5eb7\u5b81\u6770\u745e\u516c\u5e032023\u5e74\u5ea6\u4e0a\u534a\u5e74\u4e1a\u7ee9"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e748\u670824\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a9966.HK\uff09\u516c\u5e03\u4e862023\u5e74\u5ea6\u4e0a\u534a\u5e74\u4e1a\u7ee9\u548c\u6700\u65b0\u8fdb\u5c55\u3002<\/p>\n<p><b>\u8d22\u52a1\u6982\u89c8<\/b><\/p>\n<ul 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type=\"disc\">\n<li>2023\u5e745\u6708\uff0c\u5173\u4e8eKN046\u8054\u5408\u542b\u94c2\u5316\u7597\u6cbb\u7597\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08&quot;NSCLC&quot;\uff09\u60a3\u8005\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u63ed\u76f2\uff0c\u72ec\u7acb\u6570\u636e\u76d1\u5bdf\u59d4\u5458\u4f1a\u5efa\u8bae\u7814\u7a76\u7ee7\u7eed\u8fdb\u884c\u5e76\u8fdb\u4e00\u6b65\u6536\u96c6\u540e\u7eed\u7684\u968f\u8bbf\u603b\u751f\u5b58\u671f\uff08&quot;OS&quot;\uff09\u6570\u636e\uff0c\u76f4\u81f3\u6700\u7ec8OS\u5206\u6790\u3002<\/li>\n<li>2023\u5e746\u6708\uff0cKN046\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u80bf\u7624\uff08\u5c24\u5176\u662f\u9f3b\u54bd\u764c\uff09\u7684\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0c\u5728\u7ebf\u53d1\u8868\u4e8e\u56fd\u9645\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u534f\u4f1a\uff08Society for Immunotherapy of Cancer, 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3mg\/kg\u548c5mg\/kg\u6cbb\u7597\u65e2\u5f80\u94c2\u7c7b\u5316\u7597\u5931\u8d25\u6216\u4e0d\u8010\u53d7\u7684\u9cde\u72b6\u548c\u975e\u9cde\u72b6\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u5177\u6709\u826f\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/li>\n<\/ul>\n<p><b>2023\u5e74\u9884\u671f\u91cc\u7a0b\u7891<\/b><\/p>\n<ul type=\"disc\">\n<li>KN046\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80f0\u817a\u764c\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u8bfb\u51fa\u3002<\/li>\n<li>KN046\u8054\u5408\u963f\u6614\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u5168\u90e8\u60a3\u8005\u5165\u7ec4\u53ca\u90e8\u5206\u6570\u636e\u8bfb\u51fa\u3002<\/li>\n<li>KN046\u8054\u5408\u963f\u6614\u66ff\u5c3c\u6cbb\u7597PD-(L)1\u7ecf\u6cbb\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5b8c\u6210\u5927\u90e8\u5206\u60a3\u8005\u5165\u7ec4\u3002<\/li>\n<li>KN046\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u5c06\u5728ESMO\u5927\u4f1a\u516c\u5e03\u6570\u636e\u3002<\/li>\n<li>KN046\u7528\u4e8e\u65e2\u5f80EGFR-TKI(s)\u6cbb\u7597\u5931\u8d25\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC) \u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u5c06\u5728ESMO\u5927\u4f1a\u516c\u5e03\u66f4\u65b0\u6570\u636e\u3002<\/li>\n<li>KN046\u8054\u5408\u963f\u6614\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6570\u636e\u5c06\u5728ESMO\u5927\u4f1a\u9996\u6b21\u516c\u5e03\u3002<\/li>\n<li>KN046\u6cbb\u7597\u80f8\u817a\u764c\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u5c06\u5728ESMO\u5927\u4f1a\u516c\u5e03\u6570\u636e\u3002<\/li>\n<\/ul>\n<p><b>KN026<\/b><\/p>\n<p>\u65b0\u4e00\u4ee3HER2\u53cc\u6297\uff0c\u53ef\u4ee5\u540c\u65f6\u7ed3\u5408\u4e24\u79cd\u4e0d\u540c\u7684\u7ecf\u4e34\u5e8a\u9a8c\u8bc1\u7684HER2\u8868\u4f4d\uff0c\u4ece\u800c\u4ea7\u751f\u6f5c\u5728\u7684\u5353\u8d8a\u7597\u6548\u3002\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cKN026\u5bf9\u4e4b\u524d\u91cd\u5ea6\u6cbb\u7597\u7684HER2\u8868\u8fbe\u80bf\u7624\u60a3\u8005\u663e\u793a\u51fa\u826f\u597d\u7684\u521d\u6b65\u7597\u6548\u53ca\u5b89\u5168\u6027\u3002<\/p>\n<p><b>\u4e3b\u8981\u8fdb\u5c55<\/b><\/p>\n<ul type=\"disc\">\n<li>2023\u5e745\u6708\uff0c\u8054\u5408\u6ce8\u5c04\u7528\u591a\u897f\u4ed6\u8d5b\uff08\u767d\u86cb\u767d\u7ed3\u5408\u578b\uff09\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597HER2 \u9633\u6027\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u3002<\/li>\n<li>2023\u5e746\u6708\uff0cKN026\u8054\u5408KN046\u7528\u4e8e\u6cbb\u7597\u4e73\u817a\u764c\u6216GC\/GEJ\u4ee5\u5916\u7684\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027HER2\u9633\u6027\u5b9e\u4f53\u7624\u7684\u2161\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u5728\u76842023\u5e74ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\u5728\u5165\u7ec4\u768426\u4f8b\u4e73\u817a\u764c\u548c\u80c3\u764c\u4e4b\u5916\u7684\u3001HER2\u9633\u6027\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a53.8%\uff0c\u4e2d\u4f4d\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DOR\uff09\u4e3a6.8\u4e2a\u6708\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u4e3a5.6\u4e2a\u6708\uff0c12\u4e2a\u6708\u751f\u5b58\u7387\u4e3a80.4%\u3002<\/li>\n<li>2023\u5e747\u6708\uff0cKN026\u8054\u5408\u6ce8\u5c04\u7528\u591a\u897f\u4ed6\u8d5b\uff08\u767d\u86cb\u767d\u7ed3\u5408\u578b, HB1801\uff09\u4e00\u7ebf\u6cbb\u7597HER2\u9633\u6027\u590d\u53d1\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p><b>2023\u5e74\u9884\u671f\u91cc\u7a0b\u7891<\/b><\/p>\n<ul type=\"disc\">\n<li>\u63a8\u8fdbKN026\u8054\u5408\u5316\u7597\u6cbb\u7597\u4e8c\u7ebf\u53ca\u4ee5\u4e0aHER2 \u9633\u6027\u80c3\u764c\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>\u63a8\u8fdbKN026\u8054\u5408\u5316\u7597\u6cbb\u7597\u4e00\u7ebfHER2\u9633\u6027\u4e73\u817a\u764c\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>KN026\u8054\u5408\u591a\u897f\u4ed6\u8d5b\u4e00\u7ebf\u6cbb\u7597HER2\u9633\u6027\u590d\u53d1\/\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u4e24\u5e74\u968f\u8bbf\u6570\u636e\u5c06\u5728ESMO\u5927\u4f1a\u516c\u5e03\u3002<\/li>\n<li>KN026\u8054\u5408\u591a\u897f\u4ed6\u8d5b\u7528\u4e8eHER2\u9633\u6027\u65e9\u671f\u6216\u5c40\u90e8\u665a\u671f\u4e73\u817a\u764c\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u5c06\u5728ESMO\u5927\u4f1a\u66f4\u65b0\u3002<\/li>\n<\/ul>\n<p><b>JSKN003<\/b><\/p>\n<p>\u4e00\u79cd\u5229\u7528\u5eb7\u5b81\u6770\u745e\u7279\u6709\u7684\u7cd6\u5b9a\u70b9\u5076\u8054\u5e73\u53f0\u7814\u53d1\u7684HER2\u53cc\u6297ADC\uff0c\u8f83\u540c\u7c7b\u836f\u7269\u5177\u6709\u66f4\u597d\u7684\u8840\u6e05\u7a33\u5b9a\u6027\u3001\u66f4\u5f3a\u7684\u65c1\u89c2\u8005\u6740\u4f24\u6548\u5e94\u548c\u540c\u7b49\u7684\u80bf\u7624\u6740\u4f24\u6d3b\u6027\uff0c\u6709\u6548\u5730\u6269\u5927\u4e86\u6cbb\u7597\u7a97\u3002<\/p>\n<p><b>\u4e3b\u8981\u8fdb\u5c55<\/b><\/p>\n<ul type=\"disc\">\n<li>2023\u5e743\u6708\uff0cJSKN003\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u7684\u4e2d\u56fd\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<\/li>\n<\/ul>\n<p><b>2023\u5e74\u9884\u671f\u91cc\u7a0b\u7891<\/b><\/p>\n<ul type=\"disc\">\n<li>\u542f\u52a8\u76f8\u5173\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>\u5728CSCO\u5c55\u793aJSKN003\u6fb3\u5927\u5229\u4e9a\u2160\u671f\u4e34\u5e8a\u6570\u636e\u3002<\/li>\n<li>\u5728SABCS\u5e74\u4f1a\u5c55\u793aJSKN003\u6fb3\u5927\u5229\u4e9a\u2160\u671f\u548c\u4e2d\u56fd\u2160\u671f\u4e34\u5e8a\u6570\u636e<\/li>\n<\/ul>\n<p><b>KN035\uff08\u6069\u6c83\u5229\u5355\u6297\uff0c\u6069\u7ef4\u8fbe&reg;\uff09<\/b><\/p>\n<p>\u4e00\u79cd\u521b\u65b0\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u662f\u5168\u7403\u9996\u4e2a\u53ca\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684\u76ae\u4e0b\u6ce8\u5c04PD-L1\u6291\u5236\u5242\uff0c\u4e5f\u662f\u4e2d\u56fd\u7b2c\u4e00\u4e2a\u9488\u5bf9\u8de8\u7624\u79cd\u9002\u5e94\u75c7\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\u3001\u9996\u4e2a\u56fd\u4ea7PD-L1\u836f\u7269\u3002\u5177\u6709\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u3001\u4fbf\u5229\u6027\u3001\u4f9d\u4ece\u6027\u53ca\u8f83\u4f4e\u533b\u7597\u6210\u672c\u7b49\u4f18\u52bf\u3002KN035\u76ee\u524d\u6b63\u5728\u4e2d\u56fd\u8fdb\u884c\u80c6\u9053\u764c\u7684\u2162\u671f\u5173\u952e\u6027\u8bd5\u9a8c\uff0c\u5728\u7f8e\u56fd\u5f00\u5c55\u672a\u5206\u5316\u591a\u5f62\u6027\u8089\u7624\u53ca\u6076\u6027\u7ea4\u7ef4\u7ec4\u7ec7\u7ec6\u80de\u7624\u7684\u5173\u952e\u6027\u8bd5\u9a8c\u3002<\/p>\n<p><b>\u4e3b\u8981\u8fdb\u5c55<\/b><\/p>\n<ul type=\"disc\">\n<li>\u622a\u81f32023\u5e746\u6708\uff0cKN035\u5b9e\u73b0\u4ea7\u54c1\u6536\u5165117.02\u767e\u4e07\u5143\u4eba\u6c11\u5e01\uff0c\u540c\u6bd4\u589e\u957f118.87%\u3002<\/li>\n<\/ul>\n<p><b>KN052<\/b><\/p>\n<p>\u5eb7\u5b81\u6770\u745e\u81ea\u4e3b\u7814\u53d1\u7684PD-L1\/OX40\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u80fd\u540c\u65f6\u7ed3\u5408PD-L1\u4e0eOX40\uff0c\u901a\u8fc7\u963b\u65adPD-L1\/PD-1\u901a\u8def\u6709\u6548\u9006\u8f6c\u80bf\u7624\u8bf1\u5bfc\u7684\u514d\u75ab\u6291\u5236\uff0c\u5e76\u901a\u8fc7\u6fc0\u52a8OX40\u4fc3\u8fdb\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<p><b>\u4e3b\u8981\u8fdb\u5c55<\/b><\/p>\n<ul type=\"disc\">\n<li>2023\u5e742\u6708\uff0c\u4e0e\u65af\u5fae\uff08\u4e0a\u6d77\uff09\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;\u65af\u5fae\u751f\u7269&quot;\uff09\u5efa\u7acb\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u91cd\u70b9\u5f00\u5c55\u80bf\u7624\u9886\u57df\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\uff08KN052\uff09\u53camRNA\u75ab\u82d7\u836f\u7269\u7684\u4e34\u5e8a\u7814\u53d1\u5408\u4f5c\u3002<\/li>\n<li>2023\u5e744\u6708\uff0cKN052\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u57282023\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a\uff08AACR 2023\uff09Late-Breaking 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