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\u5173\u4e8e<\/b>CREDIT\u7cfb\u5217\u5173\u952e\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76<\/b><\/p>\n

CREDIT-1\u7814\u7a76\u662f\u4e00\u9879\u8bc4\u4f30\u4e2d\u56fd\u975e\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u5408\u5e76\u9ad8\u5371\/\u6781\u9ad8\u5371\u5fc3\u8840\u7ba1\u98ce\u9669\uff09\u60a3\u8005\u5e94\u7528\u6258\u83b1\u897f\u5355\u6297\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04289285\uff09\u3002\u7b2c48\u5468\u65f6\uff0c\u6258\u83b1\u897f\u5355\u6297450 mg Q4W\u7ec4\u548c600 mg Q6W\u7ec4\u7684LDL-C\u6c34\u5e73\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u767e\u5206\u6bd4\u53d8\u5316\u4e0e\u76f8\u5e94\u5b89\u6170\u5242\u7ec4\u7684\u5dee\u503c\u5206\u522b\u4e3a\u221265.04%\uff0897.5% CI\uff1a\u221270.22%, \u221259.86%\uff09\uff0c\u221257.31%\uff0897.5% CI\uff1a\u221263.95%, \u221250.68%\uff09\uff0cP\u503c\u5747<0.0001\u3002\u4e24\u7ec4LDL-C\u6c34\u5e73\u8f83\u57fa\u7ebf\u4e0b\u964d50%\u53ca\u4ee5\u4e0a\u7684\u60a3\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a87.8%\u548c71.8%\uff0c\u76f8\u5e94\u7684\u5b89\u6170\u5242\u7ec4\u5206\u522b\u4e3a1.0%\u548c2.0%\uff0c\u4e0e\u76f8\u5e94\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\u7684P\u503c\u5747<0.0001\u3002<\/p>\n

CREDIT-2\u7814\u7a76\u662f\u4e00\u9879\u8bc4\u4f30\u4e2d\u56fd\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u53d7\u8bd5\u8005\u5e94\u7528\u6258\u83b1\u897f\u5355\u6297\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167III\u671f\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04179669\uff09\u3002\u7b2c12\u5468\u65f6\uff0c\u6258\u83b1\u897f\u5355\u6297150 mg Q2W\u7ec4\u548c450 mg Q4W\u7ec4\u7684LDL-C\u6c34\u5e73\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u767e\u5206\u6bd4\u53d8\u5316\u4e0e\u76f8\u5e94\u5b89\u6170\u5242\u7ec4\u7684\u5dee\u503c\u5206\u522b\u4e3a\u221257.37%\uff0897.5% CI\uff1a\u221269.21%\uff0c\u221245.54%\uff09\u548c\u221261.90%\uff0897.5% CI\uff1a\u221273.40%\uff0c\u221250.41%\uff09\uff0cP\u503c\u5747<0.0001\u3002\u4e24\u7ec4LDL-C\u6c34\u5e73\u8f83\u57fa\u7ebf\u4e0b\u964d50%\u53ca\u4ee5\u4e0a\u7684\u60a3\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a59.6%\u548c75.0%\uff0c\u76f8\u5e94\u7684\u5b89\u6170\u5242\u7ec4\u5747\u4e3a0\uff0c\u4e0e\u76f8\u5e94\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\u7684P\u503c\u5747<0.0001\u3002<\/p>\n

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\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7www.linkedin.com\/company\/innovent-biologics\/\u3002 <\/p>\n

\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

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\u53c2\u8003\u6587\u732e<\/p>\n

[1] Huo Y, Li Y, Zhang P, et al. Efficacy and Safety of Tafolecimab in Chinese Patients With Non-Familial Hypercholesterolemia (CREDIT-1): A 48-Week Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial. Circulation. 2022;146(Suppl_1):10111.
<\/sup>[2] Zhou Y, Chai M, He Y, et al. Efficacy and Safety of Tafolecimab in Chinese Patients with Heterozygous Familial Hypercholesterolemia (CREDIT-2): A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial. ACC. 2022;1188-005\/5.
<\/sup>[3] Chai M, He Y, Zhao W, et al. Efficacy and safety of tafolecimab in Chinese patients with heterozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled phase 3 trial (CREDIT-2). BMC Med. 2023;21(1):77. Published 2023 Feb 28.
<\/sup>[4] Qi L, Liu D, Qu Y, et al. Tafolecimab in Chinese Patients With Hypercholesterolemia (CREDIT-4). JACC: Asia<\/span>. 2023<\/sup><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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\u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u7684\u970d\u52c7\u6559\u6388\u8868\u793a\uff1a"PCSK9\u6291\u5236\u5242\u662f\u4e00\u79cd\u65b0\u578b\u964d\u80c6\u56fa\u9187\u836f\u7269\uff0c\u80fd\u5f3a\u6548\u964d\u4f4eLDL-C\u6c34\u5e73\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\u6258\u83b1\u897f\u5355\u6297\u5728\u591a\u4e2a\u6ce8\u518cIII\u671f\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u964d\u8102\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u4e0e\u56fd\u5185\u5df2\u4e0a\u5e02PCSK9\u5355\u6297\u76f8\u6bd4\uff0c\u5177\u6709\u66f4\u957f\u7684\u7ed9\u836f\u95f4\u9694\u3002\u5c3d\u7ba1\u76ee\u524d\u4e34\u5e8a\u4e0a\u5df2\u6709\u591a\u79cd\u964d\u8102\u836f\u7269\uff0c\u4f46\u4e2d\u56fd\u60a3\u8005\u8840\u8102\u6574\u4f53\u8fbe\u6807\u60c5\u51b5\u5e76\u4e0d\u5c3d\u5982\u4eba\u610f\uff0c\u76f8\u4fe1\u6258\u83b1\u897f\u5355\u6297\u80fd\u4e3a\u5e7f\u5927\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u53ca\u6df7\u5408\u578b\u8840\u8102\u5f02\u5e38\u60a3\u8005\u63d0\u4f9b\u66f4\u53ef\u53ca\u548c\u4f18\u8d28\u7684\u6cbb\u7597\u9009\u62e9\u3002" \u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5b89\u8d1e\u533b\u9662\u7684\u5468\u7389\u6770\u6559\u6388\u8868\u793a\uff1a"\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u60a3\u8005\u53d1\u75c5\u5e74\u9f84\u65e9\uff0c\u5fc3\u8840\u7ba1\u98ce\u9669\u6781\u9ad8\uff0c\u5371\u5bb3\u5de8\u5927\u3002\u5373\u4f7f\u7ecf\u4e2d\u9ad8\u5242\u91cf\u4ed6\u6c40\u7c7b\u836f\u7269\u548c\u4f9d\u6298\u9ea6\u5e03\u8054\u5408\u6cbb\u7597\uff0c\u60a3\u8005\u7684\u8840\u8102\u8fbe\u6807\u7387\u4ecd\u6781\u4f4e\uff0c\u4e9f\u9700\u5f3a\u6548\u4e14\u5b89\u5168\u7684\u964d\u8102\u836f\u7269\u3002CREDIT-2\u662f\u5728\u56fd\u5185\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u4eba\u7fa4\u4e2d\u5f00\u5c55\u7684\u9996\u4e2a\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u5927\u578b\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u7ed3\u679c\u5145\u5206\u8bc1\u660e\u4e86\u6258\u83b1\u897f\u5355\u6297\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u6258\u83b1\u897f\u5355\u6297\u6210\u529f\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\uff0c\u52bf\u5fc5\u60e0\u53ca\u4e2d\u56fd\u6742\u5408\u5b50\u578b\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u60a3\u8005\u3002" 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\u5173\u4e8e\u9ad8\u80c6\u56fa\u9187\u8840\u75c7 \u8fd1\u5e74\u6765\u4e2d\u56fd\u4eba\u7fa4\u7684\u8840\u8102\u6c34\u5e73\u9010\u6b65\u5347\u9ad8\uff0c\u8840\u8102\u5f02\u5e38\u60a3\u75c5\u7387\u660e\u663e\u589e\u52a0\u3002\u4e2d\u56fd\u6210\u4eba\u8840\u8102\u5f02\u5e38\u603b\u4f53\u60a3\u75c5\u7387\u9ad8\u8fbe40.4%\u3002\u4eba\u7fa4\u8840\u6e05\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u5347\u9ad8\u5c06\u5bfc\u81f42010~2030\u5e74\u671f\u95f4\u6211\u56fd\u5fc3\u8840\u7ba1\u75c5\u4e8b\u4ef6\u7ea6\u589e\u52a0920\u4e07\u3002\u4ee5LDL-C\u6216TC\u5347\u9ad8\u4e3a\u7279\u70b9\u7684\u8840\u8102\u5f02\u5e38\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\u91cd\u8981\u7684\u72ec\u7acb\u5371\u9669\u56e0\u7d20\u3002 \u5f53\u524d\uff0c\u5728\u4e2d\u56fd\uff0c\u9ad8\u8840\u8102\u7684\u6cbb\u7597\u60c5\u51b5\u4e0d\u5bb9\u4e50\u89c2\u3002\u6839\u636e2020\u5e74\u4e2d\u56fd\u5fc3\u8840\u7ba1\u5065\u5eb7\u4e0e\u75be\u75c5\u62a5\u544a\uff0c\u73b0\u9636\u6bb5\u6211\u56fd\u6210\u5e74\u4eba\u8840\u8102\u5f02\u5e38\u8bca\u65ad\u7387\u3001\u6cbb\u7597\u7387\u548c\u63a7\u5236\u7387\u603b\u4f53\u4ecd\u5904\u4e8e\u8f83\u4f4e\u6c34\u5e73\u3002\u8840\u8102\u5f02\u5e38\u60a3\u8005LDL-C\u6cbb\u7597\u8fbe\u6807\u7387\u66f4\u662f\u4e0d\u5c3d\u7406\u60f3\u3002\u76ee\u524d\u7684\u964d\u8102\u6cbb\u7597\u4e0d\u80fd\u6ee1\u8db3\u9ad8\u8840\u8102\u9886\u57df\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u6297PCSK9\u5355\u514b\u9686\u6297\u4f53\u4f5c\u7528\u673a\u5236\u4e0d\u540c\u4e8e\u73b0\u6709\u7684\u964d\u8102\u836f\u7269\uff0c\u80fd\u6709\u6548\u964d\u4f4eLDL-C\u6c34\u5e73\uff0c\u6709\u671b\u4e3a\u4e2d\u56fd\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u60a3\u8005\u63d0\u4f9b\u66f4\u4f18\u7684\u6cbb\u7597\u9009\u62e9\u3002 \u5173\u4e8eCREDIT\u7cfb\u5217\u5173\u952e\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76 CREDIT-1\u7814\u7a76\u662f\u4e00\u9879\u8bc4\u4f30\u4e2d\u56fd\u975e\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u5408\u5e76\u9ad8\u5371\/\u6781\u9ad8\u5371\u5fc3\u8840\u7ba1\u98ce\u9669\uff09\u60a3\u8005\u5e94\u7528\u6258\u83b1\u897f\u5355\u6297\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08ClinicalTrials.gov, NCT04289285\uff09\u3002\u7b2c48\u5468\u65f6\uff0c\u6258\u83b1\u897f\u5355\u6297450 mg Q4W\u7ec4\u548c600 mg Q6W\u7ec4\u7684LDL-C\u6c34\u5e73\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u767e\u5206\u6bd4\u53d8\u5316\u4e0e\u76f8\u5e94\u5b89\u6170\u5242\u7ec4\u7684\u5dee\u503c\u5206\u522b\u4e3a\u221265.04%\uff0897.5% CI\uff1a\u221270.22%, \u221259.86%\uff09\uff0c\u221257.31%\uff0897.5% CI\uff1a\u221263.95%, 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