{"id":90513,"date":"2023-08-03T10:20:00","date_gmt":"2023-08-03T03:20:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023080310200090513"},"modified":"2023-08-03T15:24:31","modified_gmt":"2023-08-03T07:24:31","slug":"%e3%80%902023-esmo%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e4%b8%a4%e9%a1%b9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e5%b0%86%e4%ba%ae%e7%9b%b8%e6%ac%a7%e6%b4%b2%e8%82%bf%e7%98%a4%e5%86%85%e7%a7%91","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023080310200090513","title":{"rendered":"\u30102023 ESMO\u3011\u4e9a\u76db\u533b\u836f\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u5c06\u4eae\u76f8\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5e74\u4f1a\uff0c\u5176\u4e2d\u4e00\u9879\u83b7\u53e3\u5934\u62a5\u544a"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02<\/span>2023\u5e748\u67083\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5c06\u57282023\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e0a\uff0c\u5206\u522b\u4ee5\u5c0f\u578b\u53e3\u5934\u62a5\u544a\uff08mini oral\uff09\u548c\u58c1\u62a5\u7684\u5f62\u5f0f\uff0c\u516c\u5e032\u9879\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff1aBcl-2\/Bcl-xL\u53cc\u9776\u70b9\u6291\u5236\u5242APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u643aEGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6700\u65b0\u4e34\u5e8a\u6570\u636e\uff0c\u4ee5\u53ca\u4e2d\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\u5965\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff1b\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b®<\/sup>\uff09\u5728\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u8010\u836f\u7684\u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n

\n<\/p><\/div>\n

ESMO\u5e74\u4f1a\u662f\u5168\u7403\u6700\u5177\u6743\u5a01\u6027\u548c\u5f71\u54cd\u529b\u7684\u80bf\u7624\u5b66\u672f\u4f1a\u8bae\u4e4b\u4e00\uff0c\u4e3a\u5168\u7403\u4e34\u5e8a\u533b\u751f\u3001\u7814\u7a76\u4eba\u5458\u3001\u60a3\u8005\u7b49\u5c55\u793a\u6700\u65b0\u7684\u524d\u6cbf\u6570\u636e\u4e0e\u7814\u7a76\u6210\u679c\u3002\u672c\u5c4aESMO\u5e74\u4f1a\u5c06\u4e8e\u5f53\u5730\u65f6\u95f410\u670820\u65e5\u81f310\u670824\u65e5\u5728\u897f\u73ed\u7259\u9a6c\u5fb7\u91cc\u4e3e\u529e\u3002<\/p>\n

\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb<\/b>\u8868\u793a\uff1a"\u5f88\u9ad8\u5174\u770b\u5230APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597NSCLC\u60a3\u8005\u7684\u6700\u65b0\u4e34\u5e8a\u6570\u636e\u4e0e\u5965\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7597\u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u7814\u7a76\u8fdb\u5c55\u5165\u90092023 ESMO\u5e74\u4f1a\uff0c\u8fd9\u8fdb\u4e00\u6b65\u4f53\u73b0\u4e86\u516c\u53f8\u7684\u5168\u7403\u521b\u65b0\u4e0e\u4e34\u5e8a\u5f00\u53d1\u5b9e\u529b\uff0c\u4e5f\u518d\u6b21\u5c55\u73b0\u4e86\u4e9a\u76db\u533b\u836f\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u9886\u57df\u5f3a\u52b2\u7684\u6f5c\u529b\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u575a\u5b88\u5168\u7403\u521b\u65b0\u7b56\u7565\uff0c\u8fdb\u4e00\u6b65\u63a8\u52a8\u91cd\u70b9\u54c1\u79cd\u5728\u5168\u7403\u5c42\u9762\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u65e9\u65e5\u60e0\u53ca\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002"<\/p>\n

\u4e9a\u76db\u533b\u836f\u5c06\u5728\u672c\u5c4a<\/b>ESMO<\/b>\u5e74\u4f1a\u5c55\u793a\u7684\u4e24\u9879\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u5305\u62ec\uff1a<\/b><\/p>\n

APG-1252<\/u><\/b><\/p>\n

Updated study results of pelcitoclax (APG-1252) combined with osimertinib in patients (pts) with EGFR-mutant non-small cell lung cancer (NSCLC)
APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u643aEGFR\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u6210\u679c<\/p>\n

    \n
  • \u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u5c0f\u578b\u53e3\u5934\u62a5\u544a<\/li>\n
  • \u6458\u8981\u7f16\u53f7\uff1a<\/b>5586<\/li>\n
  • \u7c7b\u522b\uff1a<\/b>NSCLC\uff0c\u5c40\u90e8\u665a\u671f\uff08NSCLC, locally advanced\uff09<\/li>\n
  • \u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>\u9a6c\u5b87\u7fd4\u535a\u58eb\uff0c\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3<\/li>\n<\/ul>\n

    \u5965\u96f7\u5df4\u66ff\u5c3c<\/u><\/b><\/p>\n

    Antitumor activity of olverembatinib (HQP1351) in patients (pts) with TKI-resistant succinate dehydrogenase- (SDH-) deficient gastrointestinal stromal tumor (GIST)
    \u5965\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5728\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u8010\u836f\u7684\u7425\u73c0\u9178\u8131\u6c22\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u4e2d\u7684\u6297\u80bf\u7624\u6d3b\u6027<\/p>\n

      \n
    • \u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u58c1\u62a5<\/li>\n
    • \u6458\u8981\u7f16\u53f7\uff1a<\/b>5746<\/li>\n
    • \u7c7b\u522b\uff1a<\/b>\u8089\u7624\uff08Sarcoma\uff09<\/li>\n
    • \u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>\u90b1\u6d77\u6ce2\u535a\u58eb\uff0c\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3<\/li>\n<\/ul>\n

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      \u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/u><\/b><\/p>\n

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      \u4e9a\u76db\u533b\u836f\u524d\u77bb\u6027\u58f0\u660e<\/u><\/b><\/p>\n

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