{"id":90332,"date":"2023-08-01T20:38:00","date_gmt":"2023-08-01T13:38:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023080120380090332"},"modified":"2023-08-02T15:44:14","modified_gmt":"2023-08-02T07:44:14","slug":"%e5%85%a5%e9%80%89%e5%8f%a3%e5%a4%b4%e6%8a%a5%e5%91%8a-%e7%a7%91%e4%bc%a6%e5%8d%9a%e6%b3%b0%e5%b0%86%e4%ba%8eesmo-2023%e5%85%ac%e5%b8%83skb264%ef%bc%88mk-2870-trop2-adc%ef%bc%89%e6%b2%bb%e7%96%97hr","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023080120380090332","title":{"rendered":"\u5165\u9009\u53e3\u5934\u62a5\u544a \u79d1\u4f26\u535a\u6cf0\u5c06\u4e8eESMO 2023\u516c\u5e03SKB264\uff08MK-2870, TROP2-ADC\uff09\u6cbb\u7597HR+\/HER2-\u4e73\u817a\u764c\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c"},"content":{"rendered":"

\u4e2d\u56fd\u6210\u90fd<\/span>2023\u5e748\u67081\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0"\u79d1\u4f26\u535a\u6cf0"\uff0c\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a6990.HK\uff09\u5ba3\u5e03\u5176\u5c06\u4e8e\u5f53\u5730\u65f6\u95f4 2023 \u5e74 10 \u6708 20 \u65e5\u81f3 24 \u65e5\u5728\u897f\u73ed\u7259\u9a6c\u5fb7\u91cc\u4e3e\u884c\u76842023\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u5176\u4e0e\u9ed8\u6c99\u4e1c\u8054\u5408\u5f00\u53d1\u7684\u521b\u65b0TROP2-ADC\uff08SKB264\uff0cMK-2870\uff09\u7528\u4e8e\u7ecf\u6cbb\u7684\u8f6c\u79fb\u6027\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08HR+\uff09\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9634\u6027\uff08HER2-\uff09\u7684\u4e73\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8aI\/II \u671f\u7814\u7a76\u6570\u636e\u3002\u4eca\u5e746\u6708\uff0cSKB264\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027HR+\/HER2-\u7684\u4e73\u817a\u764c\u5df2\u83b7\u5f97\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\u3002<\/p>\n

\u8be5\u53e3\u5934\u62a5\u544a\u7684\u6458\u8981\u6807\u9898\u4e3a"SKB264 (MK-2870) in previously treated hormone receptor-positive (HR+)\/ HER2-negative metastatic breast cancer (mBC): results from a phase I\/II, single-arm, basket trial"\uff0c\u62a5\u544a\u7f16\u53f7\u4e3a380MO\u3002\u6458\u8981\u5177\u4f53\u5185\u5bb9\u9884\u8ba1\u5c06\u4e8e\u5f53\u5730\u65f6\u95f42023\u5e7410\u670816\u65e5\u5728ESMO\u5927\u4f1a\u5b98\u7f51\u4e0a\u516c\u5e03\u3002<\/p>\n

ESMO\u5927\u4f1a\u662f\u6b27\u6d32\u6700\u8d1f\u76db\u540d\u548c\u6700\u5177\u5f71\u54cd\u529b\u7684\u80bf\u7624\u5b66\u4f1a\u8bae\uff0c\u6bcf\u5e74\u6c47\u96c6\u6765\u81ea\u4e16\u754c\u5404\u5730\u7684\u4e34\u5e8a\u533b\u751f\u3001\u7814\u7a76\u4eba\u5458\u3001\u60a3\u8005\u6743\u76ca\u5021\u5bfc\u8005\u3001\u8bb0\u8005\u548c\u533b\u7597\u5065\u5eb7\u884c\u4e1a\u4ee3\u8868\uff0c\u901a\u8fc7\u5206\u4eab\u6700\u524d\u6cbf\u7684\u6570\u636e\uff0c\u4e3a\u80bf\u7624\u5b66\u5bb6\u548c\u5176\u4ed6\u5229\u76ca\u76f8\u5173\u8005\u63d0\u4f9b\u65e0\u4e0e\u4f26\u6bd4\u7684\u4ea4\u6d41\u5e73\u53f0\u548c\u9ad8\u8d28\u91cf\u7684\u6559\u80b2\u673a\u4f1a\u3002<\/p>\n

\u5173\u4e8e<\/b>SKB264<\/b>\uff08<\/b>MK-2870<\/b>\uff09<\/b><\/p>\n

SKB264\u662f\u7531\u79d1\u4f26\u535a\u6cf0\u4eab\u8a89\u56fd\u9645\u7684ADC\u7814\u53d1\u5e73\u53f0\u2014OptiDC\u7814\u53d1\u7684\u5177\u6709\u4ee3\u8868\u6027\u7684\u9776\u5411TROP2\u7684\u521b\u65b0ADC\uff0c\u91c7\u7528\u4e13\u6709\u6bd2\u7d20-\u8fde\u63a5\u5b50\u7b56\u7565\uff08Kthiol\u8bbe\u8ba1\u7b56\u7565\uff09\uff0c\u8be5\u7b56\u7565\u901a\u8fc7\u5c06\u65b0\u578b\u4e0d\u53ef\u9006\u7684\u6297\u4f53\u5076\u8054\u6280\u672f\u3001pH \u654f\u611f\u6bd2\u7d20\u91ca\u653e\u673a\u5236\u548c\u5747\u5300\u52a0\u8f7dDAR 7.4 \u7684\u4e2d\u7b49\u6d3b\u6027\u6bd2\u7d20\uff08\u65b0\u578b\u62d3\u6251\u5f02\u6784\u9176I\u6291\u5236\u5242\uff09\u76f8\u7ed3\u5408\uff0c\u5b9e\u73b0\u4e86ADC\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u4f18\u5316\u5e73\u8861[1]<\/sup>\u3002<\/p>\n

\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

SKB264\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff093\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\uff0c\u5206\u522b\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e09\u9634\u4e73\u817a\u764c\uff08TNBC\uff09\u3001EGFR-TKI\u6cbb\u7597\u5931\u8d25\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08HR+\uff09\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9634\u6027\uff08HER2-\uff09\u7684\u4e73\u817a\u764c\u3002<\/p>\n

\u57fa\u4e8e\u521d\u6b65\u4e34\u5e8a\u6570\u636e\uff0cSKB264\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u9488\u5bf9\u591a\u4e2a\u7624\u79cd\u7684\u5355\u836f\/\u8054\u7528\u7684II\u671f\u548cIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u56fd\u5185\uff0cSKB264\u5355\u836f\u6cbb\u7597\u81f3\u5c11\u7ecf\u4e8c\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684III\u671f\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u987a\u5229\uff0c\u6709\u671b\u6210\u4e3a\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u56fd\u4ea7TROP2-ADC \u3002SKB264\u5355\u836f\u7528\u4e8eTKI\u8010\u836fEGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005III\u671f\u4e34\u5e8a\u7814\u7a76\u6b63\u5feb\u901f\u63a8\u8fdb\u4e2d\u3002\u591a\u9879\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08KEYTRUDA®<\/sup>\uff0c\u6297PD-1\u5355\u6297\uff09\u6216KL-A167\uff08\u79d1\u4f26\u535a\u6cf0\u6297PD-L1\u5355\u6297\uff09II\u671f\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u5f00\u5c55\u3002\u5728\u56fd\u5916\uff0c\u79d1\u4f26\u535a\u6cf0\u5df2\u6709\u507f\u72ec\u5bb6\u8bb8\u53ef\u9ed8\u6c99\u4e1c\u5728\u4e2d\u56fd\u4ee5\u5916\uff08\u4e2d\u56fd\u5305\u62ec\u4e2d\u56fd\u5927\u9646\uff0c\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\uff09\u533a\u57df\u8303\u56f4\u5185\u7814\u53d1\u3001\u751f\u4ea7\u4e0e\u5546\u4e1a\u5316SKB264\uff08MK-2870\uff09\uff0c\u6d77\u5916\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u6cd5\u56fd\u3001\u6bd4\u5229\u65f6\u548c\u6ce2\u5170\u6709\u5e8f\u5f00\u5c55\u6216\u51c6\u5907\u5f00\u5c55\u4e2d\u3002\u591a\u9879\u5168\u7403\u591a\u4e2d\u5fc3\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76\u5728\u7b79\u5907\u4e2d\u3002<\/p>\n

\u5173\u4e8e\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/b><\/p>\n

\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0"\u79d1\u4f26\u535a\u6cf0"\uff09\u662f\u79d1\u4f26\u836f\u4e1a\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u751f\u7269\u6280\u672f\u836f\u7269\u53ca\u521b\u65b0\u5c0f\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u3001\u751f\u4ea7\u3001\u5546\u4e1a\u5316\u53ca\u56fd\u9645\u5408\u4f5c\u3002\u516c\u53f8\u56f4\u7ed5\u5168\u7403\u548c\u4e2d\u56fd\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u91cd\u70b9\u5e03\u5c40\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u708e\u75c7\u548c\u4ee3\u8c22\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\uff0c\u5efa\u8bbe\u56fd\u9645\u5316\u836f\u7269\u7814\u53d1\u4e0e\u4ea7\u4e1a\u5316\u5e73\u53f0\uff0c\u81f4\u529b\u4e8e\u6210\u4e3a\u5728\u521b\u65b0\u9886\u57df\u56fd\u9645\u9886\u5148\u7684\u4f01\u4e1a\u3002\u5728\u751f\u7269\u6280\u672f\u836f\u7269\u9886\u57df\uff0c\u5305\u62ecADC\u3001\u5355\u6297\u3001\u53cc\u6297\u3001\u65b0\u9776\u70b9\u521b\u65b0\u5c0f\u5206\u5b50\u836f\u7269\u7684\u70ed\u70b9\u6280\u672f\u7b49\uff0c\u5747\u5df2\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\u3002\u5df2\u6210\u529f\u6784\u5efa\u4eab\u8a89\u56fd\u9645\u7684ADC\u7814\u53d1\u5e73\u53f0OptiDC\uff0c\u5df2\u67094\u6b3eADC\u5904\u4e8e\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff08\u5176\u4e2d2\u4e2aADC\u9879\u76ee\u5206\u522b\u5904\u4e8e\u6ce8\u518c\u6027III\u671f\u6216NDA \u9636\u6bb5\uff09\uff0c\u591a\u6b3e\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u9636\u6bb5\u3002\u516c\u53f8\u76ee\u524d\u62e5\u670933\u4e2a\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u708e\u75c7\u3001\u4ee3\u8c22\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u9879\u76ee\uff0c14\u4e2a\u9879\u76ee\u6b63\u5728\u63a8\u8fdb\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u591a\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e3a\u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5728\u5305\u62ec\u4e2d\u56fd\u548c\u6b27\u7f8e\u7b49\u591a\u4e2a\u56fd\u5bb6\u540c\u6b65\u5f00\u5c55\u3002\u66f4\u591a\u8baf\u606f\uff0c\u656c\u8bf7\u6d4f\u89c8http:\/\/kelun-biotech.com\/<\/a>\u3002<\/p>\n

\u53c2\u8003\u8d44\u6599:<\/p>\n[1] Cheng Yezhe, et al. Preclinical profiles of SKB264, a novel anti-TROP2 antibody conjugated to topoisomerase inhibitor, demonstrated promising antitumor efficacy compared to IMMU-132. Frontiers in Oncology, Vol 12, 2022<\/p>\n

\u524d\u77bb\u6027\u9648\u8ff0<\/i><\/b><\/p>\n

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