{"id":89609,"date":"2023-07-25T22:41:00","date_gmt":"2023-07-25T15:41:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023072522410089609"},"modified":"2023-07-26T15:24:33","modified_gmt":"2023-07-26T07:24:33","slug":"%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e6%96%b0%e8%8d%afdll3-cd3%e5%8f%8c%e6%8a%97ii%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e5%9c%a8","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023072522410089609","title":{"rendered":"\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5c0f\u7ec6\u80de\u80ba\u764c\u65b0\u836fDLL3\/CD3\u53cc\u6297II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u83b7\u6279"},"content":{"rendered":"<p><p><b>\u672c\u6587\u91cd\u70b9\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0DLL3\/CD3\u53cc\u6297BI 764532\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u548c\u5176\u4ed6\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u795e\u7ecf\u5185\u5206\u6ccc\u764c\u60a3\u8005\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6279\u51c6<\/li>\n<li>\u6b64\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\u57fa\u4e8eBI 764532\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5728\u6240\u6709\u63a5\u53d7\u226590\u03bcg\/kg BI 764532\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u4e86\u80bf\u7624\u7684\u7f29\u5c0f\uff0c\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u4e45<sup>[1]<\/sup><\/li>\n<li>BI 764532\u6709\u671b\u586b\u8865\u4e34\u5e8a\u672a\u5c3d\u4e4b\u9700\uff0c\u4e3a\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e747\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 2023\u5e747\u670824\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5ba3\u5e03\uff0c\u65d7\u4e0bBI 764532\uff08DLL3\/CD3\u53cc\u6297\uff09\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\uff0c\u8be5\u8bd5\u9a8c\u662f\u4e00\u9879\u5728\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u548c\u5176\u4ed6\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u795e\u7ecf\u5185\u5206\u6ccc\u764c\u60a3\u8005\u4e2d\u8bc4\u4ef7\u9759\u8109\u8f93\u6ce8\u7528BI 764532\u7684\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u3001II\u671f\u5242\u91cf\u9009\u62e9\u8bd5\u9a8c\u3002BI 764532\u901a\u8fc7\u5bf9\u8868\u8fbe\u03b4\u68373\uff08DLL3\uff09\u5206\u5b50\u7684\u764c\u75c7\u7ec6\u80de\u8bf1\u5bfc\u514d\u75ab\u4ecb\u5bfc\u6027\u6740\u4f24\uff0c\u4ee5SCLC\u4e3a\u4ee3\u8868\u7684\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624DLL3\u8868\u8fbe\u7387\u9ad8\uff0c\u662fBI 764532\u7684\u91cd\u8981\u6f5c\u5728\u76ee\u6807\u3002\u968f\u7740\u6b64\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6b63\u5f0f\u6279\u590d\uff0c\u6807\u5fd7\u7740\u4e2d\u56fd\u540c\u6b65\u52a0\u5165BI 764532\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0&quot;\u4e2d\u56fd\u5173\u952e\uff08China Key\uff09&quot;\u9879\u76ee&quot;\u518d\u4e0b\u4e00\u57ce&quot;\uff0c\u7ee7\u7eed\u8df5\u884c\u5bf9\u4e2d\u56fd\u60a3\u8005\u7684\u627f\u8bfa\u3002<\/p>\n<p><b>\u5c0f\u7ec6\u80de\u80ba\u764c\u4e34\u5e8a\u672a\u5c3d\u4e4b\u9700<\/b><\/p>\n<p>SCLC\u5360\u80ba\u764c\u768413%~17\uff05<sup>[2]<\/sup>\uff0c\u4e0d\u4ec5\u7ec6\u80de\u5c0f\uff0c\u4e14\u5f62\u6001\u50cf\u71d5\u9ea6\u7c92\uff0c\u6240\u4ee5\u53c8\u53eb\u71d5\u9ea6\u7ec6\u80de\u764c\u3002SCLC\u662f\u4e00\u79cd\u4f4e\u5206\u5316\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\uff0c\u5177\u6709\u6076\u6027\u7a0b\u5ea6\u9ad8\u3001\u589e\u6b96\u5feb\u548c\u8f6c\u79fb\u65e9\u7684\u7279\u70b9\u3002\u6240\u4ee5\u591a\u6570\u60a3\u8005\u786e\u8bca\u7684\u65f6\u5019\u5df2\u7ecf\u6709\u8111\u3001\u809d\u810f\u3001\u9aa8\u3001\u80be\u4e0a\u817a\u7b49\u591a\u5904\u8f6c\u79fb\uff0c\u5c31\u5982\u540c&quot;\u71d5\u9ea6\u7247\u6492\u4e86\u4e00\u8eab&quot;\uff0c\u800c\u4e5f\u6b63\u662f\u8fd9\u4e9b&quot;\u81f4\u547d\u7684\u71d5\u9ea6\u7247&quot;\u5bfc\u81f4SCLC\u9884\u540e\u6781\u5dee\uff0c\u5c3d\u7ba1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08Immune Checkpoint Inhibitor\uff0cICI\uff09\u7684\u53d1\u5c55\u6539\u5584\u4e86SCLC\u60a3\u8005\u7684\u751f\u5b58\uff0c\u4f46\u5b58\u5728\u5e7f\u6cdb\u75c5\u7076\u7684\u60c5\u51b5\u4e0b\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4ecd\u4e0d\u5bb9\u4e50\u89c2\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u89e3\u51b3SCLC\u8010\u836f\u3001\u590d\u53d1\u95ee\u9898\uff0c\u5c3d\u53ef\u80fd\u5730\u5ef6\u957f\u60a3\u8005\u751f\u5b58\u671f\u6210\u4e3a\u76ee\u524d\u4e34\u5e8a\u5f00\u53d1\u7684\u96be\u70b9\u4e0e\u91cd\u70b9\u3002\u6291\u5236Notch\u4fe1\u53f7\u901a\u8def\u7684\u914d\u4f53DLL3\u5df2\u88ab\u8bc1\u5b9e\u5728\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\u7ec6\u80de\u8868\u9762\u9ad8\u8868\u8fbe\uff0c\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u524d\u666f\u7684\u6cbb\u7597\u9776\u70b9\u3002\u800cBI 764532\u4f5c\u4e3a\u4e00\u79cdDLL3\/CD3\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u901a\u8fc7CD3\u9776\u70b9\u7ed3\u5408T\u7ec6\u80de\u8868\u8fbe\u7684CD3\u540e\u6fc0\u6d3bT\u7ec6\u80de\u5e76\u4f5c\u7528\u4e8e\u8868\u8fbe\u6709DLL3\u5206\u5b50\u7684\u764c\u7ec6\u80de\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u7684\u76ee\u7684\uff0c\u7531\u4e8e\u5305\u62ecSCLC\u5728\u5185\u7684\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624DLL3\u7684\u9ad8\u8868\u8fbe\u7387\uff0cBI 764532\u6216\u80fd\u591f\u8986\u76d6\u5927\u90e8\u5206\u4eba\u7fa4\uff0c\u586b\u8865\u4e34\u5e8a\u672a\u5c3d\u4e4b\u9700\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2671\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2161268\/image_976206_54100725.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_976206_54100725.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><b>\u52a0\u901f\u5168\u7403\u7814\u53d1\u8fdb\u7a0b<\/b><\/p>\n<p>\u4ece\u76ee\u524dBI 764532\u62ab\u9732\u7684\u7814\u7a76\u6570\u636e\u6765\u770b\uff0c\u5728\u6240\u6709\u63a5\u53d7BI 764532\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a18%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a41%\u3002\u5728\u63a5\u53d7\u226590\u03bcg\/kg BI 764532 \u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u603b\u4f53ORR\u4e3a25%\uff0c\u5176\u4e2dSCLC\u53d7\u8bd5\u8005ORR 26%\uff0cepNEC\uff08\u80ba\u5916\u795e\u7ecf\u5185\u5206\u6ccc\u7624\uff09\u53d7\u8bd5\u8005ORR 19%\uff0c\u5927\u7ec6\u80de\u795e\u7ecf\u5185\u5206\u6ccc\u764c\uff08LCNEC\uff09\u53d7\u8bd5\u8005\u7684ORR\u4e3a60%\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u6240\u6709\u63a5\u53d7\u226590\u03bcg\/kg BI 764532\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u4e86\u80bf\u7624\u7684\u7f29\u5c0f\uff0c\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u4e45<sup>[1]<\/sup>\u3002<\/p>\n<p>BI 764532\u5728SCLC\u4e43\u81f3\u795e\u7ecf\u5185\u5206\u6ccc\u7624\u9886\u57df\u5df2\u7ecf\u5c55\u73b0\u51fa\u521d\u6b65\u7684\u6cbb\u7597\u6548\u679c\uff0c\u672a\u6765\u4ecd\u7136\u9700\u8981\u8fdb\u4e00\u6b65\u6df1\u5165\u63a2\u7d22\u548c\u7814\u7a76\uff0c\u4ee5\u66f4\u597d\u5730\u4e86\u89e3\u5176\u6cbb\u7597\u7684\u771f\u6b63\u6f5c\u529b\u3002<b>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4e2d\u56fd\u533b\u5b66\u548c\u7814\u53d1\u8d1f\u8d23\u4eba\u5f20\u7ef4\u535a\u58eb<\/b>\u8868\u793a\uff1a&quot;SCLC\u9884\u540e\u8f83\u5dee\uff0c\u540c\u65f6\u5e38\u89c4\u6cbb\u7597\u65b9\u6cd5\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u56e0\u6b64\uff0c\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u4ee5\u63d0\u9ad8\u60a3\u8005\u751f\u5b58\u7387\u548c\u751f\u6d3b\u8d28\u91cf\u81f3\u5173\u91cd\u8981\u3002\u5728\u6b64\u80cc\u666f\u4e0b\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0BI 764532\u7684\u521d\u6b65\u7597\u6548\u7ed9\u4e88\u4e86\u6211\u4eec\u5e0c\u671b\u3002\u6b64\u6b21BI 764532 II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5f0f\u6279\u51c6\uff0c\u6807\u5fd7\u7740\u2018\u4e2d\u56fd\u5173\u952e&#8217;\u65e9\u671f\u7814\u53d1\u9879\u76ee\u6301\u7eed\u63a8\u8fdb\u548c\u63a5\u8f68\u5168\u7403\u3002\u672a\u6765\uff0c\u901a\u8fc7\u6301\u7eed\u7684\u52aa\u529b\u548c\u6295\u5165\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u6709\u671b\u4e3a\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u4ee5\u521b\u65b0\u4e4b\u529b\u52a9\u63a8\u76f8\u5173\u533b\u5b66\u9886\u57df\u8fdb\u4e00\u6b65\u53d1\u5c55\u3002&quot;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]&nbsp;<b><a href=\"https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2023.41.16_suppl.8502\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">First-in-human dose-escalation trial of BI 764532, a delta-like ligand 3 (DLL3)\/CD3 IgG-like T-cell engager in patients (pts) with DLL3-positive (DLL3+) small-cell lung cancer (SCLC) and neuroendocrine carcinoma (NEC).<\/a> <br \/><\/b>Martin Wermke,Enriqueta Felip,Yasutoshi Kuboki,Daniel Morgensztern,Cyrus Sayehli,Miguel F. Sanmamed,Edurne Arriola,Zohra Oum&#8217;Hamed,Eric Song,Matus Studeny, andValentina Gambardella<br \/>Journal of Clinical Oncology202341:16_suppl,8502-8502<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]&nbsp;Oronsky B, Reid TR, Oronsky A, et al. What&#8217;s New in SCLC? A Review[J]. Neoplasia, 2017, 19(10):842-847.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u6587\u91cd\u70b9\uff1a \u52c3\u6797\u683c\u6bb7\u683c\u7ff0DLL3\/CD3\u53cc\u6297BI 764532\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\uff08ES-SCLC\uff09\u548c\u5176\u4ed6\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u795e\u7ecf\u5185\u5206\u6ccc\u764c\u60a3\u8005\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6279\u51c6 \u6b64\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279\u57fa\u4e8eBI 764532\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5728\u6240\u6709\u63a5\u53d7\u226590\u03bcg\/kg BI 764532\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u4e86\u80bf\u7624\u7684\u7f29\u5c0f\uff0c\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u4e45[1] BI 764532\u6709\u671b\u586b\u8865\u4e34\u5e8a\u672a\u5c3d\u4e4b\u9700\uff0c\u4e3a\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9 \u4e0a\u6d772023\u5e747\u670825\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 2023\u5e747\u670824\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5ba3\u5e03\uff0c\u65d7\u4e0bBI 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764532\u7684\u91cd\u8981\u6f5c\u5728\u76ee\u6807\u3002\u968f\u7740\u6b64\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6b63\u5f0f\u6279\u590d\uff0c\u6807\u5fd7\u7740\u4e2d\u56fd\u540c\u6b65\u52a0\u5165BI 764532\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0&quot;\u4e2d\u56fd\u5173\u952e\uff08China Key\uff09&quot;\u9879\u76ee&quot;\u518d\u4e0b\u4e00\u57ce&quot;\uff0c\u7ee7\u7eed\u8df5\u884c\u5bf9\u4e2d\u56fd\u60a3\u8005\u7684\u627f\u8bfa\u3002 \u5c0f\u7ec6\u80de\u80ba\u764c\u4e34\u5e8a\u672a\u5c3d\u4e4b\u9700 SCLC\u5360\u80ba\u764c\u768413%~17\uff05[2]\uff0c\u4e0d\u4ec5\u7ec6\u80de\u5c0f\uff0c\u4e14\u5f62\u6001\u50cf\u71d5\u9ea6\u7c92\uff0c\u6240\u4ee5\u53c8\u53eb\u71d5\u9ea6\u7ec6\u80de\u764c\u3002SCLC\u662f\u4e00\u79cd\u4f4e\u5206\u5316\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\uff0c\u5177\u6709\u6076\u6027\u7a0b\u5ea6\u9ad8\u3001\u589e\u6b96\u5feb\u548c\u8f6c\u79fb\u65e9\u7684\u7279\u70b9\u3002\u6240\u4ee5\u591a\u6570\u60a3\u8005\u786e\u8bca\u7684\u65f6\u5019\u5df2\u7ecf\u6709\u8111\u3001\u809d\u810f\u3001\u9aa8\u3001\u80be\u4e0a\u817a\u7b49\u591a\u5904\u8f6c\u79fb\uff0c\u5c31\u5982\u540c&quot;\u71d5\u9ea6\u7247\u6492\u4e86\u4e00\u8eab&quot;\uff0c\u800c\u4e5f\u6b63\u662f\u8fd9\u4e9b&quot;\u81f4\u547d\u7684\u71d5\u9ea6\u7247&quot;\u5bfc\u81f4SCLC\u9884\u540e\u6781\u5dee\uff0c\u5c3d\u7ba1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08Immune Checkpoint Inhibitor\uff0cICI\uff09\u7684\u53d1\u5c55\u6539\u5584\u4e86SCLC\u60a3\u8005\u7684\u751f\u5b58\uff0c\u4f46\u5b58\u5728\u5e7f\u6cdb\u75c5\u7076\u7684\u60c5\u51b5\u4e0b\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4ecd\u4e0d\u5bb9\u4e50\u89c2\u3002 \u56e0\u6b64\uff0c\u89e3\u51b3SCLC\u8010\u836f\u3001\u590d\u53d1\u95ee\u9898\uff0c\u5c3d\u53ef\u80fd\u5730\u5ef6\u957f\u60a3\u8005\u751f\u5b58\u671f\u6210\u4e3a\u76ee\u524d\u4e34\u5e8a\u5f00\u53d1\u7684\u96be\u70b9\u4e0e\u91cd\u70b9\u3002\u6291\u5236Notch\u4fe1\u53f7\u901a\u8def\u7684\u914d\u4f53DLL3\u5df2\u88ab\u8bc1\u5b9e\u5728\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\u7ec6\u80de\u8868\u9762\u9ad8\u8868\u8fbe\uff0c\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u524d\u666f\u7684\u6cbb\u7597\u9776\u70b9\u3002\u800cBI 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\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u603b\u4f53ORR\u4e3a25%\uff0c\u5176\u4e2dSCLC\u53d7\u8bd5\u8005ORR 26%\uff0cepNEC\uff08\u80ba\u5916\u795e\u7ecf\u5185\u5206\u6ccc\u7624\uff09\u53d7\u8bd5\u8005ORR 19%\uff0c\u5927\u7ec6\u80de\u795e\u7ecf\u5185\u5206\u6ccc\u764c\uff08LCNEC\uff09\u53d7\u8bd5\u8005\u7684ORR\u4e3a60%\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u6240\u6709\u63a5\u53d7\u226590\u03bcg\/kg BI 764532\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u4e86\u80bf\u7624\u7684\u7f29\u5c0f\uff0c\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u4e45[1]\u3002 BI 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II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5f0f\u6279\u51c6\uff0c\u6807\u5fd7\u7740\u2018\u4e2d\u56fd\u5173\u952e&#8217;\u65e9\u671f\u7814\u53d1\u9879\u76ee\u6301\u7eed\u63a8\u8fdb\u548c\u63a5\u8f68\u5168\u7403\u3002\u672a\u6765\uff0c\u901a\u8fc7\u6301\u7eed\u7684\u52aa\u529b\u548c\u6295\u5165\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u6709\u671b\u4e3a\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u4ee5\u521b\u65b0\u4e4b\u529b\u52a9\u63a8\u76f8\u5173\u533b\u5b66\u9886\u57df\u8fdb\u4e00\u6b65\u53d1\u5c55\u3002&quot; [1]&nbsp;First-in-human dose-escalation trial of BI 764532, a delta-like ligand 3 (DLL3)\/CD3 IgG-like T-cell&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2023072522410089609\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":89612,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-89609","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/89609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=89609"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/89609\/revisions"}],"predecessor-version":[{"id":89611,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/89609\/revisions\/89611"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/89612"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=89609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=89609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=89609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}