{"id":89088,"date":"2023-02-20T11:40:00","date_gmt":"2023-02-20T04:40:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023022011400089088"},"modified":"2023-02-21T01:47:54","modified_gmt":"2023-02-20T17:47:54","slug":"checkmate-274%e7%a0%94%e7%a9%b6%e4%b8%89%e5%b9%b4%e9%9a%8f%e8%ae%bf%ef%bc%9a%e6%ac%a7%e7%8b%84%e6%b2%83%e8%be%85%e5%8a%a9%e6%b2%bb%e7%96%97%e6%a0%b9%e6%b2%bb%e6%80%a7%e5%88%87%e9%99%a4%e6%9c%af","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023022011400089088","title":{"rendered":"CheckMate -274\u7814\u7a76\u4e09\u5e74\u968f\u8bbf\uff1a\u6b27\u72c4\u6c83\u8f85\u52a9\u6cbb\u7597\u6839\u6cbb\u6027\u5207\u9664\u672f\u540e\u6709\u9ad8\u590d\u53d1\u98ce\u9669\u7684\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\uff0c\u4e34\u5e8a\u751f\u5b58\u83b7\u76ca\u663e\u8457\u6301\u4e45"},"content":{"rendered":"<p><p><i>\u4e2d\u4f4d\u968f\u8bbf\u4e09\u5e74\u6570\u636e\u663e\u793a\uff0c\u6b27\u72c4\u6c83\u8f85\u52a9\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u65e0\u75c5\u751f\u5b58\u671f\u3001\u5c3f\u8def\u5916\u65e0\u590d\u53d1\u751f\u5b58\u671f\u3001\u65e0\u8fdc\u5904\u8f6c\u79fb\u751f\u5b58\u671f\u548c\u65e0\u4e8c\u6b21\u8fdb\u5c55\u751f\u5b58\u671f\u5bf9\u6bd4\u5b89\u6170\u5242\u7ec4\u5747\u83b7\u5f97\u663e\u8457\u6539\u5584<\/i><\/p>\n<p><i>\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u65e0\u75c5\u751f\u5b58\u65f6\u95f4\u4f9d\u7136\u7ef4\u6301\u662f\u5b89\u6170\u5242\u7ec4\u7684\u4e24\u500d\u4ee5\u4e0a\uff1b<\/i>&nbsp;<i>\u80bf\u7624\u7ec6\u80de<\/i><i>PD-L1<\/i><i>\u8868\u8fbe\u2265<\/i><i>1<\/i><i>\uff05\u7684\u60a3\u8005\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u65e0\u75c5\u751f\u5b58\u65f6\u95f4\u7ef4\u6301\u662f\u5b89\u6170\u5242\u7ec4\u7684\u516d\u500d\u4ee5\u4e0a<\/i><\/p>\n<p><i>CheckMate -274<\/i><i>\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\u5df2\u4e8e<\/i><i>2023<\/i><i>\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u751f\u6b96\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7814\u8ba8\u4f1a\u91cd\u78c5\u53e3\u5934\u62a5\u544a\u73af\u8282\u53d1\u8868<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e742\u670820\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u8fd1\u65e5\u516c\u5e03\u4e86III\u671f\u4e34\u5e8a\u7814\u7a76CheckMate -274\u7684\u4e09\u5e74\u968f\u8bbf\u7ed3\u679c\uff1a<i>\u6b27\u72c4\u6c83<\/i>\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff09\u8f85\u52a9\u6cbb\u7597\u6839\u6cbb\u6027\u5207\u9664\u672f\u540e\u4f34\u6709\u9ad8\u590d\u53d1\u98ce\u9669\u7684\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\uff0c\u53ef\u5e26\u6765\u663e\u8457\u6301\u4e45\u7684\u4e34\u5e8a\u751f\u5b58\u83b7\u76ca\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a36.1\u4e2a\u6708\uff08\u6700\u77ed31.6\u4e2a\u6708\uff09\u65f6\uff0c\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e0e\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u8f85\u52a9\u6cbb\u7597\u7ec4\u60a3\u8005\u7684\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u3001\u5c3f\u8def\u5916\u65e0\u590d\u53d1\u751f\u5b58\u671f\uff08NUTRFS\uff09\u3001\u65e0\u8fdc\u5904\u8f6c\u79fb\u751f\u5b58\u671f\uff08DMFS\uff09\u548c\u65e0\u4e8c\u6b21\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS2\uff09\u5747\u663e\u793a\u51fa\u4e86\u6301\u7eed\u7684\u6539\u5584\u3002\u8fd9\u4e9b\u6700\u65b0\u7814\u7a76\u6570\u636e\u5df2\u57282023\u5e742\u670816-18\u65e5\u4e3e\u884c\u76842023\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u751f\u6b96\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u7814\u8ba8\u4f1a\uff08ASCO-GU\uff09\u4e0a\u4ee5\u91cd\u78c5\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u53d1\u8868\u3002<\/p>\n<p>&quot;\u7531\u4e8e\u5fae\u8f6c\u79fb\u7076\u7684\u5b58\u5728\uff0c\u808c\u5c42\u6d78\u6da6\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u5f80\u5f80\u9762\u4e34\u9ad8\u590d\u53d1\u98ce\u9669\uff0c\u5c24\u5176\u662f\u5728\u8180\u80f1\u6216\u80be\u810f\u5207\u9664\u672f\u540e\u7684\u4e09\u5e74\u5185\u3002CheckMate -274\u7814\u7a76\u7684\u4e09\u5e74\u7ed3\u679c\u8868\u660e\uff0c\u968f\u7740\u968f\u8bbf\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u53ef\u7a33\u5b9a\u5730\u964d\u4f4e\u75be\u75c5\u590d\u53d1\u98ce\u9669\u3002&quot;<b>\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662<\/b><b>Tisch<\/b><b>\u80bf\u7624\u7814\u7a76\u6240\u533b\u5b66\u535a\u58eb\u3001\u6ccc\u5c3f\u751f\u6b96\u533b\u5b66\u80bf\u7624\u5b66\u79d1\u4e3b\u4efb\u3001\u8f6c\u5316\u7814\u7a76\u90e8\u95e8\u526f\u4e3b\u4efb\u3001\u8180\u80f1\u764c\u5353\u8d8a\u4e2d\u5fc3\u8054\u5408\u4e3b\u4efb<\/b><b><span class=\"xn-person\">Matthew Galsky<\/span><\/b><b>\u6559\u6388<\/b>\u8868\u793a\uff0c&quot;\u5bf9\u4e8e\u672f\u524d\u63a5\u53d7\u8fc7\u5316\u7597\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u5316\u7597\u7684\u60a3\u8005\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4ecd\u662f\u76ee\u524d\u552f\u4e00\u80fd\u591f\u964d\u4f4e\u672f\u540e\u5c3f\u8def\u4e0a\u76ae\u764c\u590d\u53d1\u98ce\u9669\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u4e5f\u662f\u76ee\u524d\u552f\u4e00\u7684\u836f\u7269\u6cbb\u7597\u65b9\u5f0f\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u53ef\u8c13\u6539\u53d8\u4e86\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\u6a21\u5f0f\u3002&quot;<\/p>\n<p>CheckMate -274\u7814\u7a76\u7684\u4e09\u5e74\u968f\u8bbf\u7ed3\u679c\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff0c\u4e3b\u8981\u7ec8\u70b9\uff09\uff1a\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u7684\u4e2d\u4f4dDFS\u662f\u5bf9\u7167\u7ec4\u4e24\u500d\u4ee5\u4e0a\uff0c\u5206\u522b\u4e3a22.0\u4e2a\u6708\u4e0e10.9\u4e2a\u6708\uff0c\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e29%\uff08\u98ce\u9669\u6bd4[HR] 0.71\uff0c95%\u53ef\u4fe1\u533a\u95f4&nbsp;[CI]\uff1a0.58\u81f30.86\uff09\u3002\u98ce\u9669\u964d\u4f4e\u60c5\u51b5\u4e0e\u521d\u6b65\u5206\u6790\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u4fdd\u6301\u4e00\u81f4\u3002\u5728\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u7684\u4e2d\u4f4dDFS\u662f\u5bf9\u7167\u7ec4\u7684\u516d\u500d\u4ee5\u4e0a\uff0c\u5206\u522b\u4e3a52.6\u4e2a\u6708\u4e0e8.4\u4e2a\u6708\uff08HR 0.52\uff0c95% CI\uff1a0.37\u81f30.72\uff09\uff0c\u75be\u75c5\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e48%\u3002<\/li>\n<li>\u5c3f\u8def\u5916\u65e0\u590d\u53d1\u751f\u5b58\u671f\uff08NUTRFS\uff0c\u6b21\u8981\u7ec8\u70b9\uff09\uff1a\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u7684\u4e2d\u4f4dNUTRFS\uff08\u5373\u60a3\u8005\u5728\u8180\u80f1\u3001\u8f93\u5c3f\u7ba1\u6216\u80be\u76c2\u5916\u65e0\u75be\u75c5\u590d\u53d1\u7684\u751f\u5b58\u65f6\u95f4\uff09\u4e3a25.9\u4e2a\u6708\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a13.7\u4e2a\u6708\uff08HR 0.72\uff0c95% CI\uff1a0.59\u81f30.88\uff09\u3002\u5728\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u4e0e\u5bf9\u7167\u7ec4\u7684\u4e2d\u4f4dNUTRFS\u5206\u522b\u4e3a52.6\u4e2a\u6708\u548c8.4\u4e2a\u6708\uff08HR 0.53\uff0c95% CI\uff1a0.38\u81f30.74\uff09\u3002<\/li>\n<li>\u65e0\u8fdc\u5904\u8f6c\u79fb\u751f\u5b58\u671f\uff08DMFS\uff0c\u63a2\u7d22\u6027\u7ec8\u70b9\uff09\uff1a\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u7684\u4e2d\u4f4dDMFS\uff08\u5373\u60a3\u8005\u7684\u764c\u75c7\u672a\u4ece\u539f\u53d1\u80bf\u7624\u6269\u6563\u81f3\u8fdc\u5904\u5668\u5b98\u6216\u6dcb\u5df4\u7ed3\u7684\u751f\u5b58\u65f6\u95f4\uff09\u4e3a47.1\u4e2a\u6708\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a28.7\u4e2a\u6708\uff08HR 0.74\uff0c95% &nbsp;CI\uff1a0.60\u81f30.92\uff09\u3002\u5728\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u7684\u4e2d\u4f4dDMFS\u5c1a\u672a\u8fbe\u5230\uff0c\u5bf9\u7167\u7ec4\u4e3a20.7\u4e2a\u6708\uff08HR 0.58\uff0c95% CI\uff1a0.40\u81f30.84\uff09\u3002<\/li>\n<li>\u65e0\u4e8c\u6b21\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS2\uff0c\u63a2\u7d22\u6027\u7ec8\u70b9\uff09\uff1a\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u7684\u4e2d\u4f4dPFS2\uff08\u5373\u968f\u673a\u5316\u81f3\u4e0b\u4e00\u7ebf\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u65f6\u95f4\uff09\u4e3a61.2\u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a47.1\u4e2a\u6708\uff08HR 0.79\uff0c95% CI\uff1a0.63\u81f30.98\uff09\u3002\u5728\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u7684\u4e2d\u4f4dPFS2\u5c1a\u672a\u8fbe\u5230\uff0c\u5bf9\u7167\u7ec4\u4e3a39.4\u4e2a\u6708\uff08HR 0.54\uff0c95% &nbsp;CI\uff1a0.37\u81f30.79\uff09\u3002<\/li>\n<li>\u5b89\u5168\u6027\uff1a<i>\u6b27\u72c4\u6c83<\/i>\u7ec4\u548c\u5bf9\u7167\u7ec4\u60a3\u8005\u53d1\u751f3-4\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u7684\u6bd4\u4f8b\u5206\u522b\u4e3a18.2%\u548c7.2%\uff0c\u4e0e\u521d\u6b65\u5206\u6790\u7ed3\u679c\u4fdd\u6301\u4e00\u81f4\u3002<\/li>\n<\/ul>\n<p>&quot;\u6211\u4eec\u4e00\u76f4\u5728\u52aa\u529b\u4e3a\u60a3\u8005\u63d0\u4f9b\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4ee5\u5e2e\u52a9\u4ed6\u4eec\u9884\u9632\u75be\u75c5\u590d\u53d1\uff0c\u6539\u5584\u957f\u671f\u6cbb\u7597\u6548\u679c\u3002\u4e3a\u6b64\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u59cb\u5df2\u5c06\u591a\u4e2a\u7624\u79cd\u7684\u65e9\u671f\u6cbb\u7597\u4f5c\u4e3a\u91cd\u8981\u7814\u7a76\u65b9\u5411\uff0c\u5176\u4e2d\u5c31\u5305\u62ec\u5c3f\u8def\u4e0a\u76ae\u764c\u7b49\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u96be\u6cbb\u6027\u764c\u75c7\u3002&quot;<b>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u751f\u6b96\u6ccc\u5c3f\u80bf\u7624\u5f00\u53d1\u9879\u76ee\u8d1f\u8d23\u4eba\u3001\u533b\u5b66\u535a\u58eb<\/b><b><span class=\"xn-person\">Dana Walker<\/span><\/b>\u8868\u793a\uff0c&quot;CheckMate -274\u7814\u7a76\u968f\u8bbf\u7ed3\u679c\u5c55\u73b0\u51fa\u7684\u6301\u4e45\u83b7\u76ca\u4ee4\u4eba\u6b23\u559c\uff0c\u8fd9\u4e5f\u6fc0\u52b1\u6211\u4eec\u7ee7\u7eed\u63a8\u52a8\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u7684\u5404\u9879\u65e9\u671f\u764c\u75c7\u7684\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u6316\u6398\u8fd9\u4e9b\u7814\u7a76\u6539\u53d8\u60a3\u8005\u7ed3\u5c40\u7684\u6f5c\u529b\u3002\u6211\u4eec\u5c06\u5bc6\u5207\u5173\u6ce8CheckMate -274\u7814\u7a76\u4e2d\u5176\u4ed6\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u7684\u7ed3\u679c\uff0c\u5305\u62ec\u76ee\u524d\u4ecd\u672a\u63ed\u76f2\u7684\u603b\u751f\u5b58\u671f\u7ed3\u679c\u3002&quot;<\/p>\n<p>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u611f\u8c22\u6240\u6709\u53c2\u4e0eCheckMate 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&quot;\u7531\u4e8e\u5fae\u8f6c\u79fb\u7076\u7684\u5b58\u5728\uff0c\u808c\u5c42\u6d78\u6da6\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u5f80\u5f80\u9762\u4e34\u9ad8\u590d\u53d1\u98ce\u9669\uff0c\u5c24\u5176\u662f\u5728\u8180\u80f1\u6216\u80be\u810f\u5207\u9664\u672f\u540e\u7684\u4e09\u5e74\u5185\u3002CheckMate -274\u7814\u7a76\u7684\u4e09\u5e74\u7ed3\u679c\u8868\u660e\uff0c\u968f\u7740\u968f\u8bbf\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u53ef\u7a33\u5b9a\u5730\u964d\u4f4e\u75be\u75c5\u590d\u53d1\u98ce\u9669\u3002&quot;\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662Tisch\u80bf\u7624\u7814\u7a76\u6240\u533b\u5b66\u535a\u58eb\u3001\u6ccc\u5c3f\u751f\u6b96\u533b\u5b66\u80bf\u7624\u5b66\u79d1\u4e3b\u4efb\u3001\u8f6c\u5316\u7814\u7a76\u90e8\u95e8\u526f\u4e3b\u4efb\u3001\u8180\u80f1\u764c\u5353\u8d8a\u4e2d\u5fc3\u8054\u5408\u4e3b\u4efbMatthew Galsky\u6559\u6388\u8868\u793a\uff0c&quot;\u5bf9\u4e8e\u672f\u524d\u63a5\u53d7\u8fc7\u5316\u7597\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u5316\u7597\u7684\u60a3\u8005\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4ecd\u662f\u76ee\u524d\u552f\u4e00\u80fd\u591f\u964d\u4f4e\u672f\u540e\u5c3f\u8def\u4e0a\u76ae\u764c\u590d\u53d1\u98ce\u9669\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u4e5f\u662f\u76ee\u524d\u552f\u4e00\u7684\u836f\u7269\u6cbb\u7597\u65b9\u5f0f\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u53ef\u8c13\u6539\u53d8\u4e86\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\u6a21\u5f0f\u3002&quot; CheckMate -274\u7814\u7a76\u7684\u4e09\u5e74\u968f\u8bbf\u7ed3\u679c\u5982\u4e0b\uff1a \u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff0c\u4e3b\u8981\u7ec8\u70b9\uff09\uff1a\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u4e2d\u4f4dDFS\u662f\u5bf9\u7167\u7ec4\u4e24\u500d\u4ee5\u4e0a\uff0c\u5206\u522b\u4e3a22.0\u4e2a\u6708\u4e0e10.9\u4e2a\u6708\uff0c\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e29%\uff08\u98ce\u9669\u6bd4[HR] 0.71\uff0c95%\u53ef\u4fe1\u533a\u95f4&nbsp;[CI]\uff1a0.58\u81f30.86\uff09\u3002\u98ce\u9669\u964d\u4f4e\u60c5\u51b5\u4e0e\u521d\u6b65\u5206\u6790\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u4fdd\u6301\u4e00\u81f4\u3002\u5728\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u4e2d\u4f4dDFS\u662f\u5bf9\u7167\u7ec4\u7684\u516d\u500d\u4ee5\u4e0a\uff0c\u5206\u522b\u4e3a52.6\u4e2a\u6708\u4e0e8.4\u4e2a\u6708\uff08HR 0.52\uff0c95% CI\uff1a0.37\u81f30.72\uff09\uff0c\u75be\u75c5\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e48%\u3002 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\u65e0\u8fdc\u5904\u8f6c\u79fb\u751f\u5b58\u671f\uff08DMFS\uff0c\u63a2\u7d22\u6027\u7ec8\u70b9\uff09\uff1a\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u4e2d\u4f4dDMFS\uff08\u5373\u60a3\u8005\u7684\u764c\u75c7\u672a\u4ece\u539f\u53d1\u80bf\u7624\u6269\u6563\u81f3\u8fdc\u5904\u5668\u5b98\u6216\u6dcb\u5df4\u7ed3\u7684\u751f\u5b58\u65f6\u95f4\uff09\u4e3a47.1\u4e2a\u6708\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a28.7\u4e2a\u6708\uff08HR 0.74\uff0c95% &nbsp;CI\uff1a0.60\u81f30.92\uff09\u3002\u5728\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u4e2d\u4f4dDMFS\u5c1a\u672a\u8fbe\u5230\uff0c\u5bf9\u7167\u7ec4\u4e3a20.7\u4e2a\u6708\uff08HR 0.58\uff0c95% CI\uff1a0.40\u81f30.84\uff09\u3002 \u65e0\u4e8c\u6b21\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS2\uff0c\u63a2\u7d22\u6027\u7ec8\u70b9\uff09\uff1a\u5728\u6240\u6709\u968f\u673a\u4eba\u7fa4\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u4e2d\u4f4dPFS2\uff08\u5373\u968f\u673a\u5316\u81f3\u4e0b\u4e00\u7ebf\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u65f6\u95f4\uff09\u4e3a61.2\u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a47.1\u4e2a\u6708\uff08HR 0.79\uff0c95% CI\uff1a0.63\u81f30.98\uff09\u3002\u5728\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u22651%\u7684\u60a3\u8005\u4e2d\uff0c\u6b27\u72c4\u6c83\u7ec4\u7684\u4e2d\u4f4dPFS2\u5c1a\u672a\u8fbe\u5230\uff0c\u5bf9\u7167\u7ec4\u4e3a39.4\u4e2a\u6708\uff08HR 0.54\uff0c95% &nbsp;CI\uff1a0.37\u81f30.79\uff09\u3002 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&quot;\u6211\u4eec\u4e00\u76f4\u5728\u52aa\u529b\u4e3a\u60a3\u8005\u63d0\u4f9b\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4ee5\u5e2e\u52a9\u4ed6\u4eec\u9884\u9632\u75be\u75c5\u590d\u53d1\uff0c\u6539\u5584\u957f\u671f\u6cbb\u7597\u6548\u679c\u3002\u4e3a\u6b64\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u59cb\u5df2\u5c06\u591a\u4e2a\u7624\u79cd\u7684\u65e9\u671f\u6cbb\u7597\u4f5c\u4e3a\u91cd\u8981\u7814\u7a76\u65b9\u5411\uff0c\u5176\u4e2d\u5c31\u5305\u62ec\u5c3f\u8def\u4e0a\u76ae\u764c\u7b49\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u96be\u6cbb\u6027\u764c\u75c7\u3002&quot;\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u751f\u6b96\u6ccc\u5c3f\u80bf\u7624\u5f00\u53d1\u9879\u76ee\u8d1f\u8d23\u4eba\u3001\u533b\u5b66\u535a\u58ebDana Walker\u8868\u793a\uff0c&quot;CheckMate 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