{"id":88882,"date":"2023-01-19T19:00:00","date_gmt":"2023-01-19T12:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023011919000088882"},"modified":"2023-01-19T22:53:39","modified_gmt":"2023-01-19T14:53:39","slug":"%e7%99%be%e6%82%a6%e6%b3%bd%ef%bc%88%e6%b3%bd%e5%b8%83%e6%9b%bf%e5%b0%bc%ef%bc%89%e5%9c%a8%e5%a4%a7%e4%b8%8d%e5%88%97%e9%a2%a0%e8%8e%b7%e8%8b%b1%e5%9b%bd%e8%8d%af%e5%93%81%e5%92%8c%e5%81%a5","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023011919000088882","title":{"rendered":"\u767e\u60a6\u6cfd\u00ae\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u5728\u5927\u4e0d\u5217\u98a0\u83b7\u82f1\u56fd\u836f\u54c1\u548c\u5065\u5eb7\u4ea7\u54c1\u7ba1\u7406\u5c40\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u548c\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09"},"content":{"rendered":"

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*\u4ebf\u73c2®<\/sup>\u662fPharmacyclics LLC\u548cJanssen Biotech,Inc.\u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n

References<\/b><\/p>\n[1] Tam CS, Robak T, Ghia P, et al. Zanubrutinib monotherapy for patients with treatment naive chronic lymphocytic leukemia and 17p deletion. Haematologica. 2020;106(9):2354-2363. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33054121<\/a>.<\/p>\n[2] A study of zanubrutinib (BGB-3111) versus ibrutinib in participants with relapsed\/refractory chronic lymphocytic leukemia. ClinicalTrials.gov. Accessed September 25, 2022<\/span>. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03734016<\/a><\/p>\n[3] Opat S, Tedeschi A, Linton K, et al. The MAGNOLIA Trial: Zanubrutinib, a next-generation bruton tyrosine kinase inhibitor, demonstrates safety and efficacy in relapsed\/refractory marginal zone lymphoma. Clin Cancer Res<\/span>. Published online September 15, 2021<\/span>. doi: 10.1158\/1078-0432. CCR-21-1704<\/p>\n[4] National Cancer Institute. Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Leukemia \u2014Chronic Lymphocytic Leukemia (CLL). Accessed December, 2022. https:\/\/seer.cancer.gov\/statfacts\/html\/clyl.html  <\/a><\/p>\n[5] American Cancer Society. What is chronic lymphocytic leukemia? Updated May 10, 2018. Accessed December 8, 2022. https:\/\/www.cancer.org\/cancer\/chronic-lymphocytic-leukemia\/about\/what-is-cll.html  <\/a><\/p>\n[6] Yao Y, Lin X, Li F, Jin J, Wang H. The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019. Biomed Eng Online. 2022 Jan 11;21(1):4. doi:10.1186\/s12938-021-00973-6. PMID: 35016695; PMCID: PMC8753864.<\/p>\n[7] Miranda-Filho, A., et al., Epidemiological patterns of leukaemia in 184 countries: a population-based study. The Lancet Haematology, 2018. 5(1): p. e14-e24.<\/p>\n[8] Sant, M., et al., Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood, 2010. 116(19): p. 3724-34.<\/p>\n[9]  Annals of Oncology, Marginal Zone Lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, January 6, 2020.<\/p>\n[10] Cerhan, J.R. and T.M. Habermann, Epidemiology of Marginal Zone Lymphoma. Ann Lymphoma, 2021.<\/p>\n[11] Smith, A., et al., Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK’s Haematological Malignancy Research Network. Br J Cancer, 2015. 112(9): p. 1575-84.<\/p>\n[12] Maynadie, M., et al., Splenic Marginal Zone Lymphoma: French Registries Population-Based Treatment and Survival Analyses (2002-2014). Blood, 2020. 136.<\/p>\n[13] Leukemia & Lymphoma Society, Marginal Zone Lymphoma. Available at: https:\/\/www.lls.org\/research\/marginal-zone-lymphoma-mzl<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

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*\u4ebf\u73c2®\u662fPharmacyclics LLC\u548cJanssen Biotech,Inc.\u7684\u6ce8\u518c\u5546\u6807\u3002 References [1] Tam CS, Robak T, Ghia P, et al. 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