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type=\"disc\">\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c;<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c;<\/li>\n<li>\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9634\u6027\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09;<\/li>\n<li>\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09;<\/li>\n<li>\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\uff1b<\/li>\n<li>\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002<\/li>\n<\/ul>\n<p><b>\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><b>\uff1a\u4e2d\u56fd\u552f\u4e00\u7b2c\u4e09\u4ee3<\/b><b>BCR-ABL\u6291\u5236\u5242\u9996\u6b21\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55<\/b><\/p>\n<p><b>\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u5965\u96f7\u5df4\u66ff\u5c3c\uff09<\/b>\uff1a\u662f\u4fe1\u8fbe\u751f\u7269\u4e0e\u4e9a\u76db\u533b\u836f\u5171\u540c\u5546\u4e1a\u5316\u63a8\u5e7f\u7684\u521b\u65b0\u53e3\u670d\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u6b64\u6b21\u9996\u6b21\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u533b\u4fdd\u652f\u4ed8\u8303\u56f4\u4e3a&quot;\u9650T315I\u7a81\u53d8\u7684\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08CP\uff09\u6216\u52a0\u901f\u671f\uff08AP\uff09\u7684\u6210\u5e74\u60a3\u8005&quot;\u3002<\/p>\n<p>\u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0cCML\u60a3\u8005\u53ef\u901a\u8fc7\u89c4\u8303\u670d\u836f\uff0c\u83b7\u5f97\u957f\u671f\u7684\u751f\u5b58\u83b7\u76ca\uff0c\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662fCML\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u3002\u5176\u4e2d\uff0c\u4f34\u6709T315I\u7a81\u53d8\u7684CML\u60a3\u8005\u5bf9\u76ee\u524d\u6240\u6709\u4e00\u4ee3\u3001\u4e8c\u4ee3BCR-ABL\u6291\u5236\u5242\u5747\u8010\u836f\uff0c\u957f\u671f\u56f0\u6270\u60a3\u8005\u6cbb\u7597\u3002\u8010\u7acb\u514b<sup>&reg;<\/sup>\u4f5c\u4e3a\u4e2d\u56fd\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u4e5f\u662f\u4f34T315I\u7a81\u53d8CML\u7684\u552f\u4e00\u6cbb\u7597\u836f\u7269\uff0c\u586b\u8865\u4e86\u643aT315I\u7a81\u53d8CML\u60a3\u8005\u6cbb\u7597\u7684\u7a7a\u767d\u3002\u6b64\u6b21\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u5c06\u8fdb\u4e00\u6b65\u63d0\u5347\u8010\u7acb\u514b<sup>&reg;<\/sup>\u7684\u60a3\u8005\u53ef\u53ca\u6027\u548c\u53ef\u8d1f\u62c5\u6027\uff0c\u8ba9\u66f4\u591aCML\u60a3\u8005\u5f97\u4ee5\u5ef6\u7eed\u751f\u547d\u7684\u7cbe\u5f69\u3002<\/p>\n<p><b>\u4e09\u6b3e\u6297\u4f53\u836f\u7269\u65b0\u589e\u9002\u5e94\u75c7\u7eb3\u5165\u56fd\u5bb6\u5e38\u89c4\u533b\u4fdd\u836f\u54c1\u76ee\u5f55<\/b><\/p>\n<p>\u6b64\u5916\uff0c\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff08\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u3001\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff08\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u3001\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff08\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u4e09\u6b3e\u6297\u4f53\u836f\u7269\u65b0\u589e\u591a\u9879\u9002\u5e94\u75c7\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff0c\u5c06\u4f7f\u5f97\u66f4\u5e7f\u6cdb\u7684\u80bf\u7624\u60a3\u8005\u7fa4\u4f53\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u60a3\u8005\u7fa4\u4f53\u83b7\u76ca\u3002\u5177\u4f53\u5305\u62ec\uff1a<\/p>\n<p><b>\u8fbe\u6538\u540c<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5171\u8ba1\u4e03\u9879\u9002\u5e94\u75c7\u83b7\u6279\u5e76\u5747\u5df2\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff08\u542b\u65b0\u589e\u4e09\u9879\u9002\u5e94\u75c7\uff09\u7528\u4e8e\u6cbb\u7597\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u809d\u7ec6\u80de\u764c\uff08\u8054\u5408\u963f\u66ff\u5229\u73e0\u5355\u6297\uff09\u3001\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\uff08\u65b0\u589e\uff09\uff0c\u5bab\u9888\u764c\uff08\u65b0\u589e\uff09\u53ca\u4f5c\u4e3a\u65b0\u836f\u9002\u5e94\u75c7\u7684\u809d\u7ec6\u80de\u764c\uff08\u65b0\u589e\uff0c\u8054\u5408\u4fe1\u8fea\u5229\u5355\u6297\uff09\u3002<\/li>\n<\/ul>\n<p><b>\u8fbe\u4f2f\u534e<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u5229\u59a5\u6614\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u672c\u6b21\u65b0\u589e\u521d\u6cbb\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u7ef4\u6301\u6cbb\u7597\u548c\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u4e24\u9879\u9002\u5e94\u75c7\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u8fbe\u4f2f\u534e\u5728\u4e2d\u56fd\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u5728\u5185\u7684\u591a\u9879\u8840\u6db2\u7624\u9002\u5e94\u75c7, \u5e76\u5747\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002<\/li>\n<\/ul>\n<p><b>\u82cf\u7acb\u4fe1<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u963f\u8fbe\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5171\u8ba1\u516b\u9879\u9002\u5e94\u75c7\u83b7\u6279\u5e76\u5747\u5df2\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff08\u542b\u65b0\u589e\u4e24\u9879\u9002\u5e94\u75c7\uff09\u7528\u4e8e\u6cbb\u7597\uff1a\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3001\u94f6\u5c51\u75c5\u3001\u8461\u8404\u819c\u708e\u3001\u591a\u5173\u8282\u578b\u5e7c\u5e74\u7279\u53d1\u6027\u5173\u8282\u708e\u3001\u513f\u7ae5\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u3001\u514b\u7f57\u6069\u75c5\uff08\u65b0\u589e\uff09\u548c\u513f\u7ae5\u514b\u7f57\u6069\u75c5\uff08\u65b0\u589e\uff09\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297<\/b><\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u5546\u54c1\u540d\u4e3a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u5177\u6709\u56fd\u9645\u54c1\u8d28\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684<sup>[ii]<\/sup>\u3002\u76ee\u524d\u6709\u8d85\u8fc7\u4e8c\u5341\u591a\u4e2a\u4e34\u5e8a\u7814\u7a76\uff08\u5176\u4e2d10\u591a\u9879\u662f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff09\u6b63\u5728\u8fdb\u884c\uff0c\u4ee5\u8bc4\u4f30\u4fe1\u8fea\u5229\u5355\u6297\u5728\u5404\u7c7b\u5b9e\u4f53\u80bf\u7624\u548c\u8840\u6db2\u80bf\u7624\u4e0a\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u516d\u9879\u9002\u5e94\u75c7\u5e76\u7eb3\u5165\u4e2d\u56fd\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u3002\u83b7\u6279\u9002\u5e94\u75c7\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u6216\u6c1f\u5c3f\u5627\u5576\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u542b\u6c1f\u5c3f\u5627\u5576\u7c7b\u548c\u94c2\u7c7b\u836f\u7269\u5316\u7597\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\uff0c\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9634\u6027\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u94c2\u7c7b\u5316\u7597\uff0c\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u7528\u4e8e\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff1b<\/li>\n<li>\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p>\u53e6\u5916\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u53ca\u5316\u7597\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\u6cbb\u7597\u5931\u8d25\u7684EGFR\u7a81\u53d8\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u4e2d\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u5ba1\u8bc4\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u53e6\u6709\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u7814\u7a76\u7ec8\u70b9\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5355\u836f\u7528\u4e8e\u665a\u671f\/\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e8c\u671f\u4e34\u5e8a\u7814\u7a76\uff1b<\/li>\n<li>\u5355\u836f\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e09\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u5965\u96f7\u5df4\u66ff\u5c3c\uff08<\/b><b>Olverembatinib<\/b><b>\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><b>\uff09<\/b><\/p>\n<p>\u8010\u7acb\u514b<sup>&reg;<\/sup>\u662f\u4e2d\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u7684\u4f34T315I\u7a81\u53d8\u8010\u836f\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6cbb\u7597\u836f\u7269\uff0c\u5bf9BCR-ABL\u4ee5\u53ca\u5305\u62ecT315I\u7a81\u53d8\u5728\u5185\u7684\u591a\u79cdBCR-ABL\u7a81\u53d8\u4f53\u6709\u7a81\u51fa\u6548\u679c\uff0c\u8be5\u54c1\u79cd\u4e3a\u56fd\u5bb6&quot;\u91cd\u5927\u65b0\u836f\u521b\u5236&quot;\u4e13\u9879\u652f\u6301\u54c1\u79cd\uff1b\u83b7NMPA\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u3002<\/p>\n<p>2021\u5e7411\u670825\u65e5\uff0c\u8010\u7acb\u514b<sup>&reg;<\/sup>\u83b7\u6279\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u4efb\u4f55\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u8010\u836f\uff0c\u5e76\u91c7\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bca\u65ad\u4e3a\u4f34\u6709T315I\u7a81\u53d8\u7684CML\u6162\u6027\u671f\uff08CP\uff09\u6216\u52a0\u901f\u671f\uff08AP\uff09\u7684\u6210\u5e74\u60a3\u8005\u3002\u8fd9\u6253\u7834\u4e86\u4e2d\u56fd\u4f34T315I\u7a81\u53d8\u8010\u836fCML\u60a3\u8005\u957f\u671f\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5883\uff0c\u586b\u8865\u4e86\u56fd\u5185\u4e34\u5e8a\u6cbb\u7597\u7a7a\u767d\uff0c\u5177\u6781\u5927\u793e\u4f1a\u4ef7\u503c\u3002<\/p>\n<p>\u4f5c\u4e3a\u5177\u5168\u7403best-in-class\u6f5c\u529b\u7684\u4e2d\u56fd\u539f\u521b\u65b0\u836f\uff0c\u8010\u7acb\u514b<sup>&reg;<\/sup>\u6df1\u53d7\u5168\u7403\u8840\u6db2\u5b66\u754c\u5173\u6ce8\u3002\u8be5\u54c1\u79cd\u7684\u4e34\u5e8a\u8fdb\u5c55\u8fde\u7eed\u4e94\u5e74\u5165\u9009ASH\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u5e76\u8363\u83b72019 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(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u4e49\u52a1;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n<div>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] \u5177\u4f53\u9002\u5e94\u75c7\u8bf7\u53c2\u8003\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u8bf4\u660e\u4e66\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[i] \u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u8bf4\u660e\u4e66<a href=\"http:\/\/www.cde.org.cn\/main\/xxgk\/postmarketpage?acceptidCODE=457d62d01a141c8fca2e536b49f16296\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">www.cde.org.cn\/main\/xxgk\/postmarketpage?acceptidCODE=457d62d01a141c8fca2e536b49f16296<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[ii] Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[iii] Jiang B, Ke X, Zhang Q, et al. Pharmacokinetics and safety of IBI301 versus rituximab in patients with CD20(+) B-cell lymphoma: a multicenter, randomized, double-blind, parallel-controlled study. Sci Rep. 2020;10(1): 11676.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde2023\u5e741\u670818\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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