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1. World Health Organization. International Agency for Research on Cancer. All cancers fact sheet. Available at: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/39-All-cancers-fact-sheet.pdf.<\/a> Accessed November 2022<\/span>.
2. American Cancer Society. What is Lung Cancer? Available at: https:\/\/www.cancer.org\/cancer\/lung-cancer\/about\/what-is.html.<\/a> Accessed November 2022<\/span>.
3. Knight SB, et al. Progress and prospects of early detection in lung cancer. Open Biol. 2017;7(9): 170070.
4. Keedy VL, et al. American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients with Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy. J Clin Oncol. 2011:29;2121-27.
5. Zhang Y, et al. The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis. Oncotarget. 2016;7(48).
6. Szumera-Cie\u0107kiewicz A, et al.\u202fEGFR Mutation Testing on Cytological and Histological Samples in 11. Non-Small Cell Lung Cancer: a Polish, Single Institution. Study and Systematic Review of European Incidence.\u202fInt J Clin Exp Pathol. 2013:6;2800-12.\u202f
7. Uchikawa E, et al. Structural basis of the activation of c-MET receptor. Nat Commun<\/span>. 2021;12(4074).
8. Wang Q, et al. MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer. Journal of Hematology & Oncology. 2019;63.
9. Vuong HG, et al. Clinicopathological implications of MET exon 14 mutations in non-small cell lung cancer \u2013 A systematic review and meta-analysis. Lung Cancer 2018; 123: 76-82. doi: 10.1016\/j.lungcan.2018.07.006.
10. Soria JC, et al. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(2):113-125. doi:10.1056\/NEJMoa1713137.
11. Mok TS, et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N Engl J Med. 2017;376(7):629-640. doi:10.1056\/NEJMoa1612674.
12. Hartmaier R, et al. Tumor genomics in patients (pts) with advanced epidermal growth factor receptor mutant (EGFRm) non-small cell lung cancer (NSCLC) whose disease has progressed on first-line (1L) osimertinib therapy in the Phase II ORCHARD study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; Abstract nr LB078 \/ 3.
13. Piotrowska, et al.  MET amplification (amp) as a resistance mechanism to osimertinib. Journal of Clinical Oncology 2017 35:15_suppl, 9020-9020 
14. Hartmaier, et al. Detection of MET-mediated EGFR tyrosine kinase inhibitor (TKI) resistance in advanced non-small cell lung cancer (NSCLC): biomarker analysis of the TATTON study. Cancer Res (2019) 79 (13_Supplement): 4897.doi: 10.1158\/1538-7445.AM2019-4897.
15. Coleman N, et al. Beyond epidermal growth factor receptor: MET amplification as a general resistance driver to targeted therapy in oncogene-driven non-small-cell lung cancer. ESMO Open. 2019;6(6)<\/p>\n

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 <\/p>\n

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\u53c2\u8003\u8d44\u6599 1. World Health Organization. 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