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silencing\uff08Fc\u6548\u5e94\u6c89\u9ed8\uff09\uff0c\u6d88\u9664\u4e0eFc\u53d7\u4f53\u7ed3\u5408\u7684\u80fd\u529b\u3002\u8fd9\u6837\u7684\u6539\u9020\u4e00\u65b9\u9762\u5b8c\u5168\u53bb\u9664\u4e86ADCC\/ADCP\/CDC\u6548\u5e94\uff0c\u663e\u8457\u51cf\u5c11\u6548\u5e94T\u7ec6\u80de\u8017\u635f\uff0c\u53e6\u4e00\u65b9\u9762\uff0cFc\u6bb5\u6539\u9020\u964d\u4f4eADCR\u6548\u5e94\uff0c\u51cf\u5c11IL-8\u7684\u91ca\u653e\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u514d\u75ab\u7597\u6548\u3002\u6b64\u5916\uff0cADCR\u6548\u5e94\u7684\u964d\u4f4e\u8fd8\u610f\u5473\u7740IL-6\u7684\u91ca\u653e\u51cf\u5c11\uff0c\u4ece\u800c\u51cf\u5c11irAEs\uff0c\u8868\u73b0\u4e3a\u4e34\u5e8a\u6570\u636e\u4e0a\u5b89\u5168\u6027\u7684\u63d0\u5347\u3002<\/p>\n<p><b>2021\u5e748\u67085\u65e5\uff0c\u6d3e\u5b89\u666e\u5229\u5355\u6297\u83b7\u5f97NMPA\u6279\u51c6\u7528\u4e8e\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/b><\/p>\n<p>\u6b64\u5916\uff0c\u6d3e\u5b89\u666e\u5229\u5355\u6297\u6cbb\u7597\u9f3b\u54bd\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u53ca\u80c3\u764c\u7b49\u591a\u4e2a\u7624\u79cd\u7684\u7814\u7a76\u4ea6\u5728\u7a33\u6b65\u63a8\u8fdb\u5f53\u4e2d\uff0c\u8fd9\u4e9b\u7814\u7a76\u6216\u5df2\u5728ASCO\u7b49\u56fd\u9645\u821e\u53f0\u591a\u6b21\u4eae\u76f8\uff0c\u6216\u5df2\u5b8c\u6210\u5165\u7ec4\u7b49\u5f85\u6700\u7ec8\u6570\u636e\u7684\u63ed\u6653\uff0c\u6d3e\u5b89\u666e\u5229\u5355\u6297\u7684\u4e34\u5e8a\u524d\u666f\u503c\u5f97\u671f\u5f85\u3002<\/p>\n<p><b>AK105-302\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u97e9\u5b9d\u60e0\u6559\u6388<\/b>\u8c08\u5230\uff1a&quot;\u6d3e\u5b89\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u9cde\u72b6NSCLC\u53d6\u5f97\u4e86\u4ee4\u4eba\u6b23\u559c\u7684\u7814\u7a76\u6210\u679c\uff0c\u5e76\u7eb3\u5165\u300a2022 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Therapeutics\u4e8e\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u72ec\u5bb6\u8bb8\u53ef\u6743\u3002\u5eb7\u65b9\u751f\u7269\u671f\u671b\u901a\u8fc7\u9ad8\u6548\u53ca\u7a81\u7834\u6027\u7684\u7814\u53d1\u521b\u65b0\u5f00\u53d1\u56fd\u9645\u9996\u521b\u53ca\u540c\u7c7b\u836f\u7269\u6700\u4f73\u7597\u6cd5\u7684\u65b0\u836f\uff0c\u6210\u4e3a\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e\uff1a<br \/>[1] \u4e2d\u534e\u533b\u5b66\u6742\u5fd7.2020.100(46):3659-3673.<br \/>[2] <span class=\"xn-person\">Baohui Han<\/span>, et al. 2022 ESMO IO,59MO.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac2023\u5e741\u670814\u65e5 \/\u7f8e\u901a\u793e\/ 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Therapeutics\u4e8e\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6b27\u6d32\u548c\u65e5\u672c\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u72ec\u5bb6\u8bb8\u53ef\u6743\u3002\u5eb7\u65b9\u751f\u7269\u671f\u671b\u901a\u8fc7\u9ad8\u6548\u53ca\u7a81\u7834\u6027\u7684\u7814\u53d1\u521b\u65b0\u5f00\u53d1\u56fd\u9645\u9996\u521b\u53ca\u540c\u7c7b\u836f\u7269\u6700\u4f73\u7597\u6cd5\u7684\u65b0\u836f\uff0c\u6210\u4e3a\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002 \u53c2\u8003\u6587\u732e\uff1a[1] \u4e2d\u534e\u533b\u5b66\u6742\u5fd7.2020.100(46):3659-3673.[2]&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2023011415160088777\">Read 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