{"id":88765,"date":"2023-01-11T20:17:00","date_gmt":"2023-01-11T13:17:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2023011120170088765"},"modified":"2023-01-11T22:11:22","modified_gmt":"2023-01-11T14:11:22","slug":"%e4%ba%8c%e5%8d%81%e5%b9%b4%e9%87%8d%e5%a4%a7%e7%aa%81%e7%a0%b4-%e8%82%ba%e7%99%8c%e9%9d%b6%e5%90%91%e8%8d%af%e7%89%a9%e7%90%a5%e7%8f%80%e9%85%b8%e8%8e%ab%e5%8d%9a%e8%b5%9b%e6%9b%bf%e5%b0%bc%e8%83%b6","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2023011120170088765","title":{"rendered":"\u4e8c\u5341\u5e74\u91cd\u5927\u7a81\u7834 \u80ba\u764c\u9776\u5411\u836f\u7269\u7425\u73c0\u9178\u83ab\u535a\u8d5b\u66ff\u5c3c\u80f6\u56ca\u4e2d\u56fd\u83b7\u6279"},"content":{"rendered":"<p><p>&#8211;&nbsp; <i>\u6b66\u7530\u653b\u514b\u4e8c\u5341\u5e74\u4e34\u5e8a\u96be\u9898\uff0c\u5e26\u6765\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u6279\u4e13\u4e3a<\/i><i>EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7814\u53d1\u7684\u53e3\u670d\u9776\u5411\u836f\u7269\uff0c\u5f00\u521b\u9776\u5411\u6cbb\u7597\u65b0\u7eaa\u5143<\/i><\/p>\n<p>&#8211;&nbsp; <i>\u83ab\u535a\u8d5b\u66ff\u5c3c\u83b7\u5f97<\/i><i>CDE\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\uff0c\u901a\u8fc7\u5168\u7403\u540c\u6b65\u5f00\u53d1\u3001\u540c\u6b65\u9012\u4ea4\u52a0\u901f\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005<\/i><\/p>\n<p>&#8211;&nbsp; <i>\u9488\u5bf9\u94c2\u7c7b\u5316\u7597\u8fdb\u5c55\u60a3\u8005\uff0c\u83ab\u535a\u8d5b\u66ff\u5c3c\u6cbb\u7597\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<\/i><i>mPFS\uff09\u5ef6\u957f\u52307.3\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff0920.2\u4e2a\u6708\uff0c\u5e2e\u52a9\u60a3\u8005\u5b9e\u73b0\u751f\u5b58\u7a81\u7834\uff0c\u586b\u8865\u4e34\u5e8a\u6cbb\u7597\u7a7a\u767d<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e741\u670811\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u6b66\u7530\u4e2d\u56fd\u4eca\u65e5\u5ba3\u5e03\uff0c\u65d7\u4e0b\u80ba\u764c\u521b\u65b0\u6cbb\u7597\u836f\u7269\u7425\u73c0\u9178\u83ab\u535a\u8d5b\u66ff\u5c3c\u80f6\u56ca\uff0c\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;\u83ab\u535a\u8d5b\u66ff\u5c3c&quot;\uff09\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u6b63\u5f0f\u8fdb\u5165\u4e2d\u56fd\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u4e4b\u540e\u8fdb\u5c55\u4e14\u643a\u5e26\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff0920\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002<sup>[1][2]<\/sup>\u83ab\u535a\u8d5b\u66ff\u5c3c\u662f\u5168\u7403\u9996\u6b3e<sup>[3]<\/sup>\u4e5f\u662f\u76ee\u524d<sup>[4]<\/sup>\u552f\u4e00<sup>[5]<\/sup>\u83b7\u6279\u7684\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\uff08EGFR exon20 Insertion+\uff09\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u53e3\u670d\u9776\u5411\u836f\u7269\uff0c\u5176\u83b7\u6279\u6807\u5fd7\u7740EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u53f2\u4e0a\u4e8c\u5341\u5e74\u6765<sup>[6]<\/sup>\u7684\u91cd\u5927\u7a81\u7834\uff0c\u5ba3\u544a\u9488\u5bf9\u8fd9\u4e00\u75be\u75c5\u7684\u6cbb\u7597\u5728\u4e2d\u56fd\u6b63\u5f0f\u8fdb\u5165\u9776\u5411\u6cbb\u7597\u65b0\u7eaa\u5143\u3002<\/p>\n<p>\u80ba\u764c\u4f4d\u5c45\u4e2d\u56fd\u6076\u6027\u80bf\u7624\u53d1\u75c5\u7387\u53ca\u6b7b\u4ea1\u7387\u9996\u4f4d<sup>[7]<\/sup>\uff0c\u5176\u4e2d\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u662f\u80ba\u764c\u6700\u5e38\u89c1\u7684\u7c7b\u578b<sup>[8]<\/sup>\u3002EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u53d1\u751f\u7387\u7ea6\u5360\u4e2d\u56fd\u6240\u6709NSCLC\u76842.3%<sup>[9]<\/sup>\uff0c\u662fEGFR\u7b2c\u4e09\u5927\u7a81\u53d8\u3002\u5bf9\u6bd4\u5e38\u89c1EGFR\u7a81\u53d8\uff0cEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u751f\u5b58\u9884\u540e\u66f4\u5dee\uff0c5\u5e74\u751f\u5b58\u7387\u4ec5\u4e3a8%<sup>[10]<\/sup>\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u9488\u5bf9\u8fd9\u4e00\u75be\u75c5\u7684\u6cbb\u7597\u4f9d\u8d56\u5316\u7597\u4e3a\u4e3b\uff0c\u7f3a\u4e4f\u6709\u6548\u9776\u5411\u6cbb\u7597\u65b9\u6848\u3002\u6839\u636e\u4e00\u9879\u771f\u5b9e\u4e16\u754c\u6570\u636e\u663e\u793a\uff0c\u5728\u7f3a\u4e4f\u9488\u5bf9\u6027\u6709\u6548\u6cbb\u7597\u60c5\u51b5\u4e0b\uff0c\u665a\u671fEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u60a3\u8005\u4e8c\u7ebf\u53ca\u540e\u7ebf\u6cbb\u7597\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4f4e\u4e8e10%\uff0cPFS\u4ec5\u4e3a3.7\u4e2a\u6708\uff0cOS\u4ec5\u4e3a13.6\u4e2a\u6708<sup>[11]<\/sup>\u3002<\/p>\n<p>\u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u83b7\u6279\u6253\u7834\u8fd9\u4e00\u6cbb\u7597\u56f0\u5883\uff0c\u586b\u8865\u4e86\u4e34\u5e8a\u7684\u6cbb\u7597\u7a7a\u767d\uff0c\u4e3aEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5e26\u6765\u751f\u5b58\u5e0c\u671b\u3002\u6b64\u6b21\u83b7\u6279\u662f\u57fa\u4e8e1\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7ed3\u679c\uff0c\u7814\u7a76\u5728\u5168\u7403\u8303\u56f4\u5185\u7eb3\u5165114\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u94c2\u7c7b\u5316\u7597\u7684\u60a3\u8005\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u7ecf\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\uff0c\u60a3\u8005\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523028%\uff0c\u7814\u7a76\u8005\uff08INV\uff09\u8bc4\u4f30\u7684ORR\u8fbe\u523035%\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9ad8\u8fbe78%\uff0cIRC\u8bc4\u4f30\u7684\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08mDoR\uff09\u5ef6\u957f\u81f315.8\u4e2a\u6708\u3002<\/li>\n<li>\u60a3\u8005\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u63d0\u9ad8\u52307.3\u4e2a\u6708\uff0c\u60a3\u8005\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09\u7a81\u7834\u81f320.2\u4e2a\u6708<sup>[12]<\/sup>\u3002<\/li>\n<\/ul>\n<p>\u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u6210\u529f\u5f97\u76ca\u4e8e\u5728\u836f\u7269\u7ed3\u6784\u4e0a\u7684\u521b\u65b0\u3002EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u4f53\u5f62\u6210\u7684\u7a7a\u95f4\u4f4d\u963b\u5bfc\u81f4\u836f\u7269\u7ed3\u5408\u53e3\u888b\u53d8\u5c0f\uff0c\u4e14\u8be5\u7a81\u53d8\u540c\u91ce\u751f\u578bEGFR\u7ed3\u6784\u9ad8\u5ea6\u76f8\u4f3c\uff0c\u56e0\u6b64\u4f7f\u5f97\u4f20\u7edfEGFR\u9776\u5411\u836f\u7269\u7ed3\u5408\u53d7\u963b\uff0c\u5bf9\u4e8e\u7814\u53d1\u65b0\u836f\u7684\u9009\u62e9\u6027\u548c\u4eb2\u548c\u529b\u6709\u975e\u5e38\u9ad8\u7684\u8981\u6c42\u3002\u83ab\u535a\u8d5b\u66ff\u5c3c\u4e13\u95e8\u9488\u5bf9EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u8bbe\u8ba1\uff0c\u5176\u521b\u65b0\u7684\u5f02\u4e19\u916f\u7ed3\u6784\u5f62\u6210\u67d4\u6027\u5355\u73af\u6838\u5fc3\uff0c\u53ef\u4ee5\u66f4\u6709\u6548\u5730\u4e0eEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u6709\u6548\u7ed3\u5408<sup>[13]<\/sup>\uff0c\u5177\u6709\u7cbe\u51c6\u9009\u62e9\u548c\u9ad8\u5ea6\u4eb2\u548c\u7684\u4f18\u52bf\uff0c\u4ece\u800c\u653b\u514b\u8fd9\u4e00\u4e34\u5e8a\u96be\u9898\u3002<\/p>\n<p>\u6b66\u7530\u5236\u836f\u5168\u7403\u9ad8\u7ea7\u526f\u603b\u88c1\uff0c\u6b66\u7530\u4e2d\u56fd\u603b\u88c1\u5355\u56fd\u6d2a\u8868\u793a\uff1a&quot;\u5728\u6b66\u7530\u548c\u56fd\u5185\u4e34\u5e8a\u4e13\u5bb6\u7684\u643a\u624b\u5408\u4f5c\u548c\u5171\u540c\u52aa\u529b\u4e0b\uff0c\u6211\u4eec\u975e\u5e38\u5174\u594b\u5730\u4e0e\u5927\u5bb6\u5206\u4eab\u83ab\u535a\u8d5b\u66ff\u5c3c\u4eca\u5929\u5728\u56fd\u5185\u6b63\u5f0f\u83b7\u6279\u7684\u597d\u6d88\u606f\u3002\u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u83b7\u6279\u662f\u8be5\u9776\u70b9\u81ea\u53d1\u73b0\u4e8c\u5341\u5e74\u4ee5\u6765\u7684\u91cd\u5927\u7a81\u7834\uff0c\u5f70\u663e\u4e86\u4e2d\u56fd\u653f\u5e9c\u9f13\u52b1\u548c\u52a0\u901f\u5f15\u8fdb\u521b\u65b0\u836f\u7269\u7684\u51b3\u5fc3\uff0c\u4e3a\u60a3\u8005\u53ca\u5bb6\u5ead\u5e26\u6765\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u79c9\u627f\u2018\u4ee5\u60a3\u8005\u4e3a\u5148&#8217;\u7684\u521d\u5fc3\uff0c\u672a\u6765\u6b66\u7530\u5c06\u6301\u7eed\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u521b\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u5e76\u643a\u624b\u5404\u65b9\u5171\u540c\u63d0\u5347\u4e2d\u56fd\u80ba\u764c\u8bca\u7597\u6c34\u5e73\uff0c\u4e3a\u5b9e\u73b0\u2018\u5065\u5eb7\u4e2d\u56fd2030&#8217;\u4e2d\u56fd\u603b\u4f53\u764c\u75c75\u5e74\u751f\u5b58\u7387\u63d0\u9ad815%\u7684\u76ee\u6807\u8d21\u732e\u529b\u91cf\u3002&quot;<\/p>\n<p>\u4f5c\u4e3a\u6b66\u7530\u5168\u7403\u7814\u53d1\u7684\u56db\u5927\u5173\u952e\u533a\u57df\u4e4b\u4e00\uff0c\u4e2d\u56fd\u5728\u5168\u7403\u836f\u7269\u5f00\u53d1\u4e2d\u53d1\u6325\u7740\u4e3b\u529b\u519b\u7684\u4f5c\u7528\u3002\u6b66\u7530\u5168\u7403\u7814\u53d1\u526f\u603b\u88c1\u3001\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u8d1f\u8d23\u4eba\u738b\u7498\u535a\u58eb\u8868\u793a\uff1a&quot;\u83ab\u535a\u8d5b\u66ff\u5c3c\u662f\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u8fdb\u5165\u5168\u7403\u540c\u6b65\u5f00\u53d1\u9636\u6bb5\u4ee5\u6765\u7684\u9996\u4e2a\u521b\u65b0\u6210\u679c\uff0c\u5177\u6709\u7a81\u7834\u6027\u7684\u610f\u4e49\u3002\u4f5c\u4e3a\u6b66\u7530\u5168\u7403\u7814\u53d1\u7684\u91cd\u8981\u5f15\u64ce\u4e4b\u4e00\uff0c\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u59cb\u7ec8\u81f4\u529b\u4e8e\u4e3a\u4e2d\u56fd\u4ee5\u53ca\u4e9a\u6d32\u60a3\u8005\u5e26\u6765\u56fd\u9645\u524d\u6cbf\u7684\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u3002\u5728\u83ab\u535a\u8d5b\u66ff\u5c3c\u5168\u7403\u5173\u952e\u6027\u7814\u7a76\u4e2d\uff0c\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u4e0e\u4e2d\u56fd\u4e13\u5bb6\u7d27\u5bc6\u5408\u4f5c\uff0c\u8ba9\u4e2d\u56fd\u60a3\u8005\u80fd\u5c3d\u5feb\u4e0e\u5168\u7403\u540c\u6b65\u7528\u4e0a\u521b\u65b0\u7684\u6cbb\u7597\u836f\u7269\u3002\u672a\u6765\u6211\u4eec\u4e5f\u5c06\u7ee7\u7eed\u52a0\u5f3a\u5bf9\u4e2d\u56fd\u7814\u53d1\u4f53\u7cfb\u7684\u6295\u5165\uff0c\u643a\u624b\u5404\u65b9\u53d1\u6398\u4e2d\u56fd\u521b\u65b0\u6f5c\u529b\uff0c\u8d4b\u80fd\u5168\u7403\u65b0\u836f\u5f00\u53d1\u3002&quot;<\/p>\n[1] \u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u4e0a\u5e02\u7533\u8bf7\u901a\u8fc7\u56fd\u5bb6\u836f\u76d1\u5c40\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\u9644\u6761\u4ef6\u6279\u51c6<br \/>[2]&nbsp;\u7425\u73c0\u9178\u83ab\u535a\u8d5b\u66ff\u5c3c\u80f6\u56ca\u8bf4\u660e\u4e66<br \/>[3] Mobocertinib: First Approval\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34716908\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34716908<\/a> &nbsp;<br \/>[4]&nbsp;\u622a\u6b62\u81f32023\u5e741\u6708<br \/>[5] <a href=\"https:\/\/www.cancernetwork.com\/view\/mobocertinib-receives-fda-approval-for-previously-treated-nsclc-with-egfr-exon-20-insertion-mutations\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.cancernetwork.com\/view\/mobocertinib-receives-fda-approval-for-previously-treated-nsclc-with-egfr-exon-20-insertion-mutations<\/a><br \/>[6]&nbsp;Hiroyuki Y, et al. Lancet Oncol 2012&nbsp;; 13&nbsp;:e23-31<br \/>[7]&nbsp;<a href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a><br \/>[8] American Cancer Society. What is Non-Small Cell Lung Cancer? <a href=\"https:\/\/www.cancer.org\/cancer\/non-small-cell-lung-cancer\/about\/what-is-non-small-cell-lung-cancer.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.cancer.org\/cancer\/non-small-cell-lung-cancer\/about\/what-is-non-small-cell-lung-cancer.html<\/a> &nbsp;<br \/>[9]&nbsp;Qin Y, et al.Mol Oncol.&nbsp;2020;14(8):1695-1704<br \/>[10] <span class=\"xn-person\">Lyudmila Bazhenova<\/span>, et al.Lung Cancer. 2021; 162:154-161<br \/>[11]&nbsp;Sai-Hong Ignatius Ou, et al. 2021ASCO. Abstract#9098<br \/>[12]&nbsp;&nbsp;Caicun Zhou, PhD, MD; <span class=\"xn-person\">Suresh S. Ramalingam<\/span>, MD , et al. JAMA Oncology, Treatment Outcomes and Safety of Mobocertinib in Platinum-Pretreated Patients With EGFR Exon 20 Insertion\u2013PositiveMetastatic, Non\u2013Small Cell Lung Cancer, A Phase 1\/2 Open-label Nonrandomized Clinical Tria<br \/>[13]&nbsp;Francois Gonzalvez, <span class=\"xn-person\">Sylvie Vincent<\/span>, <span class=\"xn-person\">Theresa E. Baker<\/span> , et al. Mobocertinib(TAK 788)&nbsp;: a targeted inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer<\/p>\n<p><b>\u5173\u4e8e\u6b66\u7530\u5236\u836f<\/b><\/p>\n<p>\u6b66\u7530\u5236\u836f\uff08<a href=\"https:\/\/www.takeda.com\/investors\/\" target=\"_blank\" rel=\"nofollow noopener\">\u4e1c\u4eac\u8bc1\u5238\u4ea4\u6613\u6240\u80a1\u7968\u4ee3\u7801\uff1a4502<\/a>\uff09\uff08\u7ebd\u7ea6\u8bc1\u5238\u4ea4\u6613\u6240\u80a1\u7968\u4ee3\u7801\uff1aTAK\uff09\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u3001\u4ee5\u4ef7\u503c\u89c2\u4e3a\u57fa\u7840\u3001\u4ee5\u7814\u53d1\u4e3a\u9a71\u52a8\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u6b66\u7530\u81f4\u529b\u4e8e\u5c06\u79d1\u5b66\u7814\u53d1\u6210\u679c\u8f6c\u5316\u4e3a\u9ad8\u5ea6\u521b\u65b0\u836f\u54c1\uff0c\u4e3a\u60a3\u8005\u7684\u5065\u5eb7\u751f\u6d3b\u548c\u7f8e\u597d\u672a\u6765\u4fdd\u9a7e\u62a4\u822a\u3002\u6b66\u7530\u4e13\u6ce8\u4e8e\u56db\u5927\u6cbb\u7597\u9886\u57df\u7684\u836f\u7269\u7814\u53d1\uff1a\u80bf\u7624\u3001\u6d88\u5316\u3001\u795e\u7ecf\u79d1\u5b66\u53ca\u7f55\u89c1\u75c5\u9886\u57df\uff0c\u5e76\u9488\u5bf9\u8840\u6db2\u5236\u54c1\u53ca\u75ab\u82d7\u9886\u57df\u8fdb\u884c\u4e13\u9879\u7814\u53d1\u6295\u5165\u3002\u6211\u4eec\u59cb\u7ec8\u4e13\u6ce8\u4e8e\u9ad8\u5ea6\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\uff0c\u901a\u8fc7\u5f00\u62d3\u5168\u65b0\u6cbb\u7597\u65b9\u6848\u3001\u589e\u5f3a\u5408\u4f5c\u7814\u53d1\u5f15\u64ce\u5b9e\u529b\uff0c\u6253\u9020\u4e00\u6761\u7a33\u5065\u4e14\u5f62\u5f0f\u591a\u6837\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u52a9\u529b\u6539\u5584\u4eba\u4eec\u7684\u751f\u6d3b\u3002\u6211\u4eec\u7684\u5458\u5de5\u904d\u5e03\u4e8e\u5927\u7ea680\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\uff0c\u4e0e\u5f53\u5730\u533b\u7597\u5065\u5eb7\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u5065\u5eb7\u798f\u97f3\u3002<\/p>\n<p>\u6b66\u7530\u4e8e1994\u5e74\u8fdb\u5165\u4e2d\u56fd\uff0c\u6b66\u7530\u4e2d\u56fd\u603b\u90e8\u4f4d\u4e8e\u4e0a\u6d77\uff0c\u5728\u4e2d\u56fd\u5927\u9646\u7684\u4e3b\u8981\u4e1a\u52a1\u4e2d\u5fc3\u4f4d\u4e8e\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u5929\u6d25\u3001\u5e7f\u5dde\u3001\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u7b49\u57ce\u5e02\u548c\u5730\u533a\uff0c\u5e76\u5728\u5168\u56fd\u5404\u4e3b\u8981\u57ce\u5e02\u8bbe\u6709\u529e\u4e8b\u5904\uff0c\u76ee\u524d\u5728\u4e2d\u56fd\u62e5\u6709\u8d85\u8fc72000\u540d\u5458\u5de5\u3002\u968f\u7740\u4e2d\u56fd\u7ecf\u6d4e\u7684\u53d1\u5c55\u548c\u5bf9\u533b\u7597\u4fdd\u5065\u9700\u6c42\u7684\u4e0d\u65ad\u589e\u957f\uff0c\u4e2d\u56fd\u5df2\u7ecf\u6210\u4e3a\u6b66\u7530\u5168\u7403\u6700\u91cd\u8981\u7684\u65b0\u5174\u5e02\u573a\u4e4b\u4e00\u3002<\/p>\n<p>\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u8bbf\u95ee<a href=\"https:\/\/www.takeda.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.takeda.com<\/a><\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u7a3f\u4ef6\u53ca\u4e0e\u4e4b\u76f8\u5173\u7684\u6240\u5206\u53d1\u7684\u4efb\u4f55\u8d44\u6599\u53ef\u80fd\u542b\u6709\u4e0e\u6b66\u7530\u672a\u6765\u4e1a\u52a1\u3001\u672a\u6765\u72b6\u51b5\u548c\u8fd0\u8425\u4e1a\u7ee9\u6709\u5173\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3001\u770b\u6cd5\u6216\u610f\u89c1\uff0c\u5305\u62ec\u6b66\u7530\u7684\u9884\u4f30\u3001\u9884\u6d4b\u3001\u76ee\u6807\u548c\u8ba1\u5212\u3002\u524d\u77bb\u6027\u9648\u8ff0\u5e38\u5e38\u5305\u542b\u4f46\u4e0d\u9650\u4e8e\u4e0b\u5217\u63aa\u8f9e\uff0c\u4f8b\u5982&quot;\u76ee\u6807&quot;\u3001&quot;\u8ba1\u5212&quot;\u3001&quot;\u8ba4\u4e3a&quot;\u3001&quot;\u5e0c\u671b&quot;\u3001&quot;\u7ee7\u7eed&quot;\u3001&quot;\u9884\u8ba1&quot;\u3001&quot;\u65e8\u5728&quot;\u3001&quot;\u6253\u7b97&quot;\u3001&quot;\u786e\u4fdd&quot;\u3001&quot;\u5c06&quot;\u3001&quot;\u53ef\u80fd&quot;\u3001&quot;\u5e94&quot;\u3001&quot;\u4f1a&quot;\u3001&quot;\u6216\u8bb8&quot;\u3001&quot;\u9884\u671f&quot;\u3001&quot;\u4f30\u8ba1&quot;\u3001&quot;\u9884\u6d4b&quot;\u6216\u7c7b\u4f3c\u8868\u8ff0\u6216\u5176\u5426\u5b9a\u5f62\u5f0f\u3002<\/p>\n<p>\u672c\u6587\u4e2d\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u57fa\u4e8e\u6b66\u7530\u622a\u81f3\u53d1\u5e03\u65e5\u671f\u7684\u4f30\u8ba1\u548c\u5047\u8bbe\u3002\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u5e76\u975e\u662f\u6b66\u7530\u6216\u5176\u7ba1\u7406\u5c42\u5bf9\u672a\u6765\u4e1a\u7ee9\u6240\u505a\u7684\u4efb\u4f55\u4fdd\u8bc1\uff0c\u5e76\u6d89\u53ca\u5df2\u77e5\u548c\u672a\u77e5\u7684\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u548c\u5176\u4ed6\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u6b66\u7530\u5168\u7403\u4e1a\u52a1\u6240\u9762\u4e34\u7684\u7ecf\u6d4e\u5f62\u52bf\uff0c\u5305\u62ec\u65e5\u672c\u548c\u7f8e\u56fd\u7684\u5b8f\u89c2\u7ecf\u6d4e\u73af\u5883\uff1b\u7ade\u4e89\u538b\u529b\u548c\u53d1\u5c55\u60c5\u51b5\uff1b\u9002\u7528\u6cd5\u5f8b\u6cd5\u89c4\u7684\u53d8\u52a8\uff1b\u4ea7\u54c1\u5f00\u53d1\u9879\u76ee\u7684\u6210\u529f\u6216\u5931\u8d25\uff1b\u76d1\u7ba1\u5f53\u5c40\u7684\u51b3\u7b56\u6216\u505a\u51fa\u51b3\u7b56\u7684\u65f6\u673a\uff1b\u5229\u7387\u548c\u6c47\u7387\u6ce2\u52a8\uff1b\u6709\u5173\u5df2\u552e\u4ea7\u54c1\u6216\u5019\u9009\u4ea7\u54c1\u5b89\u5168\u6216\u529f\u6548\u7684\u7d22\u8d54\u6216\u7591\u95ee\uff1b\u5df2\u6536\u8d2d\u516c\u53f8\u7684\u5408\u5e76\u540e\u6574\u5408\u52aa\u529b\u7684\u65f6\u673a\u548c\u5f71\u54cd\uff1b\u4ee5\u53ca\u80fd\u5426\u5265\u79bb\u5bf9\u6b66\u7530\u8fd0\u8425\u975e\u6838\u5fc3\u7684\u8d44\u4ea7\u548c\u4efb\u4f55\u6b64\u7c7b\u5265\u79bb\u7684\u65f6\u673a\uff0c\u6240\u6709\u8fd9\u4e9b\u90fd\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6b66\u7530\u7684\u5b9e\u9645\u4e1a\u7ee9\u3001\u8868\u73b0\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u4e0e\u6b64\u7c7b\u524d\u77bb\u6027\u9648\u8ff0\u6240\u63cf\u8ff0\u6216\u6697\u6307\u7684\u4efb\u4f55\u672a\u6765\u4e1a\u7ee9\u3001\u8868\u73b0\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u53d1\u751f\u91cd\u5927\u504f\u5dee\u3002<\/p>\n<p>\u5173\u4e8e\u4ee5\u4e0a\u53ca\u53ef\u80fd\u5f71\u54cd\u6b66\u7530\u7ed3\u679c\u3001\u4e1a\u7ee9\u3001\u6210\u5c31\u6216\u8d22\u52a1\u72b6\u51b5\u7684\u5176\u4ed6\u56e0\u7d20\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u53c2\u9605\u6b66\u7530\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u63d0\u4ea4\u7684Form 20-F\u6700\u65b0\u5e74\u62a5&quot;\u7b2c3\u9879. \u5173\u952e\u4fe1\u606f\u2014D. \u98ce\u9669\u56e0\u7d20&quot;\u548c\u5176\u4ed6\u62a5\u544a\uff0c\u5177\u4f53\u8bf7\u67e5\u9605\u6b66\u7530\u7f51\u7ad9https:\/\/www.takeda.com\/investors\/reports\/sec-filings\/\u6216www.sec.gov\u3002\u6b66\u7530\u7684\u672a\u6765\u7ed3\u679c\u3001\u4e1a\u7ee9\u6210\u5c31\u6216\u8d22\u52a1\u5730\u4f4d\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u6240\u8a00\u4f20\u6216\u610f\u4f1a\u7684\u5185\u5bb9\u6709\u5b9e\u8d28\u6027\u5dee\u8ddd\u3002\u6536\u5230\u8fd9\u4e00\u65b0\u95fb\u7a3f\u7684\u4e2a\u4eba\u4e0d\u5e94\u5bf9\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u5bc4\u4e88\u4e0d\u9002\u5207\u7684\u4f9d\u8d56\u3002\u6b66\u7530\u6ca1\u6709\u4e49\u52a1\u66f4\u65b0\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u6216\u516c\u53f8\u53ef\u80fd\u53d1\u5e03\u7684\u4efb\u4f55\u5176\u4ed6\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u9664\u975e\u662f\u6cd5\u5f8b\u6216\u8bc1\u5238\u4ea4\u6613\u89c4\u5219\u6240\u8981\u6c42\u3002\u5386\u53f2\u4e1a\u7ee9\u5e76\u4e0d\u80fd\u4ee3\u8868\u672a\u6765\u4e1a\u7ee9\uff0c\u800c\u4e14\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6b66\u7530\u4e1a\u7ee9\u5e76\u4e0d\u80fd\u6307\u4ee3\uff0c\u4e5f\u5e76\u975e\u662f\u6b66\u7530\u672a\u6765\u4e1a\u7ee9\u7684\u9884\u4f30\u3001\u9884\u6d4b\u6216\u63a8\u6d4b\u3002<\/p>\n<p><b>\u533b\u5b66\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u5305\u542b\u7684\u836f\u54c1\u4fe1\u606f\u53ef\u80fd\u5e76\u975e\u5728\u6240\u6709\u56fd\u5bb6\/\u5730\u533a\u9002\u7528\uff0c\u6216\u5728\u4e0d\u540c\u7684\u56fd\u5bb6\/\u5730\u533a\u53ef\u80fd\u9002\u7528\u4e0d\u540c\u7684\u5546\u6807\u3001\u9002\u5e94\u75c7\u6216\u60a3\u8005\u4f7f\u7528\u5242\u91cf\u3002\u672c\u6587\u65e8\u5728\u4f20\u9012\u533b\u836f\u524d\u6cbf\u4fe1\u606f\uff0c\u4e0d\u6784\u6210\u5bf9\u4efb\u4f55\u836f\u7269\u6216\u8bca\u7597\u65b9\u6848\u7684\u63a8\u8350\u6216\u63a8\u5e7f\u3002\u5982\u60a8\u60f3\u4e86\u89e3\u66f4\u591a\u75be\u75c5\u77e5\u8bc6\u6216\u836f\u54c1\u3001\u8bca\u7597\u76f8\u5173\u4fe1\u606f\uff0c\u8bf7\u54a8\u8be2\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u3002<\/p>\n<p>\u5ba1\u6279\u7f16\u53f7\uff1aC-ANPROM\/CN\/EXK\/0004<\/p>\n<p>\u5ba1\u6279\u65e5\u671f\uff1a2022\u5e7412\u6708<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211;&nbsp; \u6b66\u7530\u653b\u514b\u4e8c\u5341\u5e74\u4e34\u5e8a\u96be\u9898\uff0c\u5e26\u6765\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u6279\u4e13\u4e3aEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7814\u53d1\u7684\u53e3\u670d\u9776\u5411\u836f\u7269\uff0c\u5f00\u521b\u9776\u5411\u6cbb\u7597\u65b0\u7eaa\u5143 &#8211;&nbsp; \u83ab\u535a\u8d5b\u66ff\u5c3c\u83b7\u5f97CDE\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\uff0c\u901a\u8fc7\u5168\u7403\u540c\u6b65\u5f00\u53d1\u3001\u540c\u6b65\u9012\u4ea4\u52a0\u901f\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005 &#8211;&nbsp; \u9488\u5bf9\u94c2\u7c7b\u5316\u7597\u8fdb\u5c55\u60a3\u8005\uff0c\u83ab\u535a\u8d5b\u66ff\u5c3c\u6cbb\u7597\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u5ef6\u957f\u52307.3\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff0920.2\u4e2a\u6708\uff0c\u5e2e\u52a9\u60a3\u8005\u5b9e\u73b0\u751f\u5b58\u7a81\u7834\uff0c\u586b\u8865\u4e34\u5e8a\u6cbb\u7597\u7a7a\u767d \u4e0a\u6d772023\u5e741\u670811\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u6b66\u7530\u4e2d\u56fd\u4eca\u65e5\u5ba3\u5e03\uff0c\u65d7\u4e0b\u80ba\u764c\u521b\u65b0\u6cbb\u7597\u836f\u7269\u7425\u73c0\u9178\u83ab\u535a\u8d5b\u66ff\u5c3c\u80f6\u56ca\uff0c\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;\u83ab\u535a\u8d5b\u66ff\u5c3c&quot;\uff09\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u6b63\u5f0f\u8fdb\u5165\u4e2d\u56fd\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u542b\u94c2\u5316\u7597\u671f\u95f4\u6216\u4e4b\u540e\u8fdb\u5c55\u4e14\u643a\u5e26\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff0920\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002[1][2]\u83ab\u535a\u8d5b\u66ff\u5c3c\u662f\u5168\u7403\u9996\u6b3e[3]\u4e5f\u662f\u76ee\u524d[4]\u552f\u4e00[5]\u83b7\u6279\u7684\u6cbb\u7597EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\uff08EGFR exon20 Insertion+\uff09\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u53e3\u670d\u9776\u5411\u836f\u7269\uff0c\u5176\u83b7\u6279\u6807\u5fd7\u7740EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u53f2\u4e0a\u4e8c\u5341\u5e74\u6765[6]\u7684\u91cd\u5927\u7a81\u7834\uff0c\u5ba3\u544a\u9488\u5bf9\u8fd9\u4e00\u75be\u75c5\u7684\u6cbb\u7597\u5728\u4e2d\u56fd\u6b63\u5f0f\u8fdb\u5165\u9776\u5411\u6cbb\u7597\u65b0\u7eaa\u5143\u3002 \u80ba\u764c\u4f4d\u5c45\u4e2d\u56fd\u6076\u6027\u80bf\u7624\u53d1\u75c5\u7387\u53ca\u6b7b\u4ea1\u7387\u9996\u4f4d[7]\uff0c\u5176\u4e2d\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u662f\u80ba\u764c\u6700\u5e38\u89c1\u7684\u7c7b\u578b[8]\u3002EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u53d1\u751f\u7387\u7ea6\u5360\u4e2d\u56fd\u6240\u6709NSCLC\u76842.3%[9]\uff0c\u662fEGFR\u7b2c\u4e09\u5927\u7a81\u53d8\u3002\u5bf9\u6bd4\u5e38\u89c1EGFR\u7a81\u53d8\uff0cEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u751f\u5b58\u9884\u540e\u66f4\u5dee\uff0c5\u5e74\u751f\u5b58\u7387\u4ec5\u4e3a8%[10]\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u9488\u5bf9\u8fd9\u4e00\u75be\u75c5\u7684\u6cbb\u7597\u4f9d\u8d56\u5316\u7597\u4e3a\u4e3b\uff0c\u7f3a\u4e4f\u6709\u6548\u9776\u5411\u6cbb\u7597\u65b9\u6848\u3002\u6839\u636e\u4e00\u9879\u771f\u5b9e\u4e16\u754c\u6570\u636e\u663e\u793a\uff0c\u5728\u7f3a\u4e4f\u9488\u5bf9\u6027\u6709\u6548\u6cbb\u7597\u60c5\u51b5\u4e0b\uff0c\u665a\u671fEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u60a3\u8005\u4e8c\u7ebf\u53ca\u540e\u7ebf\u6cbb\u7597\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4f4e\u4e8e10%\uff0cPFS\u4ec5\u4e3a3.7\u4e2a\u6708\uff0cOS\u4ec5\u4e3a13.6\u4e2a\u6708[11]\u3002 \u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u83b7\u6279\u6253\u7834\u8fd9\u4e00\u6cbb\u7597\u56f0\u5883\uff0c\u586b\u8865\u4e86\u4e34\u5e8a\u7684\u6cbb\u7597\u7a7a\u767d\uff0c\u4e3aEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5e26\u6765\u751f\u5b58\u5e0c\u671b\u3002\u6b64\u6b21\u83b7\u6279\u662f\u57fa\u4e8e1\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7ed3\u679c\uff0c\u7814\u7a76\u5728\u5168\u7403\u8303\u56f4\u5185\u7eb3\u5165114\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u94c2\u7c7b\u5316\u7597\u7684\u60a3\u8005\uff1a \u7ecf\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\uff0c\u60a3\u8005\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523028%\uff0c\u7814\u7a76\u8005\uff08INV\uff09\u8bc4\u4f30\u7684ORR\u8fbe\u523035%\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9ad8\u8fbe78%\uff0cIRC\u8bc4\u4f30\u7684\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08mDoR\uff09\u5ef6\u957f\u81f315.8\u4e2a\u6708\u3002 \u60a3\u8005\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u63d0\u9ad8\u52307.3\u4e2a\u6708\uff0c\u60a3\u8005\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09\u7a81\u7834\u81f320.2\u4e2a\u6708[12]\u3002 \u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u6210\u529f\u5f97\u76ca\u4e8e\u5728\u836f\u7269\u7ed3\u6784\u4e0a\u7684\u521b\u65b0\u3002EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u4f53\u5f62\u6210\u7684\u7a7a\u95f4\u4f4d\u963b\u5bfc\u81f4\u836f\u7269\u7ed3\u5408\u53e3\u888b\u53d8\u5c0f\uff0c\u4e14\u8be5\u7a81\u53d8\u540c\u91ce\u751f\u578bEGFR\u7ed3\u6784\u9ad8\u5ea6\u76f8\u4f3c\uff0c\u56e0\u6b64\u4f7f\u5f97\u4f20\u7edfEGFR\u9776\u5411\u836f\u7269\u7ed3\u5408\u53d7\u963b\uff0c\u5bf9\u4e8e\u7814\u53d1\u65b0\u836f\u7684\u9009\u62e9\u6027\u548c\u4eb2\u548c\u529b\u6709\u975e\u5e38\u9ad8\u7684\u8981\u6c42\u3002\u83ab\u535a\u8d5b\u66ff\u5c3c\u4e13\u95e8\u9488\u5bf9EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u8bbe\u8ba1\uff0c\u5176\u521b\u65b0\u7684\u5f02\u4e19\u916f\u7ed3\u6784\u5f62\u6210\u67d4\u6027\u5355\u73af\u6838\u5fc3\uff0c\u53ef\u4ee5\u66f4\u6709\u6548\u5730\u4e0eEGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u6709\u6548\u7ed3\u5408[13]\uff0c\u5177\u6709\u7cbe\u51c6\u9009\u62e9\u548c\u9ad8\u5ea6\u4eb2\u548c\u7684\u4f18\u52bf\uff0c\u4ece\u800c\u653b\u514b\u8fd9\u4e00\u4e34\u5e8a\u96be\u9898\u3002 \u6b66\u7530\u5236\u836f\u5168\u7403\u9ad8\u7ea7\u526f\u603b\u88c1\uff0c\u6b66\u7530\u4e2d\u56fd\u603b\u88c1\u5355\u56fd\u6d2a\u8868\u793a\uff1a&quot;\u5728\u6b66\u7530\u548c\u56fd\u5185\u4e34\u5e8a\u4e13\u5bb6\u7684\u643a\u624b\u5408\u4f5c\u548c\u5171\u540c\u52aa\u529b\u4e0b\uff0c\u6211\u4eec\u975e\u5e38\u5174\u594b\u5730\u4e0e\u5927\u5bb6\u5206\u4eab\u83ab\u535a\u8d5b\u66ff\u5c3c\u4eca\u5929\u5728\u56fd\u5185\u6b63\u5f0f\u83b7\u6279\u7684\u597d\u6d88\u606f\u3002\u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u83b7\u6279\u662f\u8be5\u9776\u70b9\u81ea\u53d1\u73b0\u4e8c\u5341\u5e74\u4ee5\u6765\u7684\u91cd\u5927\u7a81\u7834\uff0c\u5f70\u663e\u4e86\u4e2d\u56fd\u653f\u5e9c\u9f13\u52b1\u548c\u52a0\u901f\u5f15\u8fdb\u521b\u65b0\u836f\u7269\u7684\u51b3\u5fc3\uff0c\u4e3a\u60a3\u8005\u53ca\u5bb6\u5ead\u5e26\u6765\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u79c9\u627f\u2018\u4ee5\u60a3\u8005\u4e3a\u5148&#8217;\u7684\u521d\u5fc3\uff0c\u672a\u6765\u6b66\u7530\u5c06\u6301\u7eed\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u521b\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u5e76\u643a\u624b\u5404\u65b9\u5171\u540c\u63d0\u5347\u4e2d\u56fd\u80ba\u764c\u8bca\u7597\u6c34\u5e73\uff0c\u4e3a\u5b9e\u73b0\u2018\u5065\u5eb7\u4e2d\u56fd2030&#8217;\u4e2d\u56fd\u603b\u4f53\u764c\u75c75\u5e74\u751f\u5b58\u7387\u63d0\u9ad815%\u7684\u76ee\u6807\u8d21\u732e\u529b\u91cf\u3002&quot; \u4f5c\u4e3a\u6b66\u7530\u5168\u7403\u7814\u53d1\u7684\u56db\u5927\u5173\u952e\u533a\u57df\u4e4b\u4e00\uff0c\u4e2d\u56fd\u5728\u5168\u7403\u836f\u7269\u5f00\u53d1\u4e2d\u53d1\u6325\u7740\u4e3b\u529b\u519b\u7684\u4f5c\u7528\u3002\u6b66\u7530\u5168\u7403\u7814\u53d1\u526f\u603b\u88c1\u3001\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u8d1f\u8d23\u4eba\u738b\u7498\u535a\u58eb\u8868\u793a\uff1a&quot;\u83ab\u535a\u8d5b\u66ff\u5c3c\u662f\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u8fdb\u5165\u5168\u7403\u540c\u6b65\u5f00\u53d1\u9636\u6bb5\u4ee5\u6765\u7684\u9996\u4e2a\u521b\u65b0\u6210\u679c\uff0c\u5177\u6709\u7a81\u7834\u6027\u7684\u610f\u4e49\u3002\u4f5c\u4e3a\u6b66\u7530\u5168\u7403\u7814\u53d1\u7684\u91cd\u8981\u5f15\u64ce\u4e4b\u4e00\uff0c\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u59cb\u7ec8\u81f4\u529b\u4e8e\u4e3a\u4e2d\u56fd\u4ee5\u53ca\u4e9a\u6d32\u60a3\u8005\u5e26\u6765\u56fd\u9645\u524d\u6cbf\u7684\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u3002\u5728\u83ab\u535a\u8d5b\u66ff\u5c3c\u5168\u7403\u5173\u952e\u6027\u7814\u7a76\u4e2d\uff0c\u6b66\u7530\u4e9a\u592a\u7814\u53d1\u4e0e\u4e2d\u56fd\u4e13\u5bb6\u7d27\u5bc6\u5408\u4f5c\uff0c\u8ba9\u4e2d\u56fd\u60a3\u8005\u80fd\u5c3d\u5feb\u4e0e\u5168\u7403\u540c\u6b65\u7528\u4e0a\u521b\u65b0\u7684\u6cbb\u7597\u836f\u7269\u3002\u672a\u6765\u6211\u4eec\u4e5f\u5c06\u7ee7\u7eed\u52a0\u5f3a\u5bf9\u4e2d\u56fd\u7814\u53d1\u4f53\u7cfb\u7684\u6295\u5165\uff0c\u643a\u624b\u5404\u65b9\u53d1\u6398\u4e2d\u56fd\u521b\u65b0\u6f5c\u529b\uff0c\u8d4b\u80fd\u5168\u7403\u65b0\u836f\u5f00\u53d1\u3002&quot; [1] \u83ab\u535a\u8d5b\u66ff\u5c3c\u7684\u4e0a\u5e02\u7533\u8bf7\u901a\u8fc7\u56fd\u5bb6\u836f\u76d1\u5c40\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\u9644\u6761\u4ef6\u6279\u51c6[2]&nbsp;\u7425\u73c0\u9178\u83ab\u535a\u8d5b\u66ff\u5c3c\u80f6\u56ca\u8bf4\u660e\u4e66[3] Mobocertinib: First Approval\uff1ahttps:\/\/pubmed.ncbi.nlm.nih.gov\/34716908 &nbsp;[4]&nbsp;\u622a\u6b62\u81f32023\u5e741\u6708[5] https:\/\/www.cancernetwork.com\/view\/mobocertinib-receives-fda-approval-for-previously-treated-nsclc-with-egfr-exon-20-insertion-mutations[6]&nbsp;Hiroyuki Y, et al. Lancet Oncol 2012&nbsp;; 13&nbsp;:e23-31[7]&nbsp;https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf[8] American Cancer Society. What is Non-Small Cell Lung Cancer? https:\/\/www.cancer.org\/cancer\/non-small-cell-lung-cancer\/about\/what-is-non-small-cell-lung-cancer.html &nbsp;[9]&nbsp;Qin Y,&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2023011120170088765\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-88765","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/88765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=88765"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/88765\/revisions"}],"predecessor-version":[{"id":88766,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/88765\/revisions\/88766"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=88765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=88765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=88765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}