{"id":87960,"date":"2022-12-15T07:00:00","date_gmt":"2022-12-15T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121507000087960"},"modified":"2022-12-15T22:21:19","modified_gmt":"2022-12-15T14:21:19","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e4%b8%8elg%e5%8c%96%e5%ad%a6%e8%be%be%e6%88%90%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%ef%bc%8c%e5%bc%95%e8%bf%9b%e7%97%9b%e9%a3%8e%e9%a2%86%e5%9f%9f%e5%85%a8%e6%96%b0","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121507000087960","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u4e0eLG\u5316\u5b66\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u5f15\u8fdb\u75db\u98ce\u9886\u57df\u5168\u65b0\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff08XOI\uff09Tigulixostat"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14, \u4e2d\u56fd\u82cf\u5dde\u548c\u97e9\u56fd\u9996\u5c14<\/span><span class=\"legendSpanClass\">2022\u5e7412\u670815\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e0eLG\u5316\u5b66\u65d7\u4e0b\u7684LG\u5316\u5b66\u751f\u547d\u79d1\u5b66\uff08\u4e0b\u79f0\u201cLG\u5316\u5b66\u201d\uff09\uff0c\u5ba3\u5e03\u53cc\u65b9\u5c31\u7531LG\u5316\u5b66\u7814\u53d1\u7684\u4e34\u5e8a\u540e\u671f\u521b\u65b0\u836f\u7269Tigulixostat\uff08LG\u7814\u53d1\u4ee3\u53f7: LC350189, \u4fe1\u8fbe\u751f\u7269\u7814\u53d1\u4ee3\u53f7: IBI350\uff09\u2014\u2014\u4e00\u6b3e\u6cbb\u7597\u75db\u98ce\u60a3\u8005\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u5168\u65b0\u975e\u560c\u5464\u7c7b\u4f3c\u7269\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff08XOI\uff09\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002<\/p>\n<p>\u5728\u4e00\u9879\u4e8e\u7f8e\u56fd\u5b8c\u6210\u76842\u671f\u4e34\u5e8a\u7814\u7a76\uff08CLUE\u7814\u7a76\uff09\u4e2d\uff0cTigulixostat\u5728\u6240\u6709\u5242\u91cf\u7ec4\u5747\u5c55\u73b0\u51fa\u826f\u597d\u7684\u964d\u8840\u5c3f\u9178\u6c34\u5e73\uff08sUA\uff09\u4f5c\u7528\uff0c\u5e76\u4e14\u548c\u5b89\u6170\u5242\u53ca\u975e\u5e03\u53f8\u4ed6\uff08Febuxostat\uff09\u76f8\u6bd4\uff0cTigulixostat\u5728\u6cbb\u75973\u4e2a\u6708\u540e\u6240\u6709\u5242\u91cf\u7ec4\u5747\u8fbe\u5230\u4e86sUA&lt;5mg\/dL\u7684\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9<sup>[1],[2]<\/sup>\u3002LG\u5316\u5b66\u5df2\u4e8e2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u542f\u52a8Tigulixostat\u7684\u56fd\u9645\u591a\u4e2d\u5fc33\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4fe1\u8fbe\u751f\u7269\u5c06\u83b7\u5f97Tigulixostat\u5728\u4e2d\u56fd\u7684\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002LG\u5316\u5b66\u5c06\u83b7\u5f971,000\u4e07\u7f8e\u91d1\u7684\u5408\u4f5c\u9996\u4ed8\u6b3e\uff0c\u5e76\u5c06\u6709\u8d44\u683c\u83b7\u5f97\u603b\u989d\u4e0d\u8d85\u8fc78,550\u4e07\u7f8e\u91d1\u7684\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u57fa\u4e8e\u4e2d\u56fd\u5730\u533a\u5e74\u5ea6\u51c0\u9500\u552e\u989d\u7684\u68af\u5ea6\u7279\u8bb8\u4f7f\u7528\u8d39\u3002<\/p>\n<p>\u9ad8\u5c3f\u9178\u8840\u75c7\u5df2\u6210\u4e3a\u7ee7\u9ad8\u8840\u538b\u3001\u9ad8\u8840\u8102\u3001\u9ad8\u8840\u7cd6\u201c\u4e09\u9ad8\u201d\u4e4b\u540e\u7684\u201c\u7b2c\u56db\u9ad8\u201d\u3002\u4e2d\u56fd\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u75c5\u7387\u7ea613.3% \uff081.87\u4ebf\u4eba\uff09<sup>[3]<\/sup>\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u662f\u5bfc\u81f4\u75db\u98ce\u75c5\u7684\u5148\u51b3\u6761\u4ef6\uff0c\u5728\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u4e2d\u75db\u98ce\u4eba\u7fa4\u7ea6\u4e3a1550\u4e07\u3002\u6d77\u5185\u5916\u75db\u98ce\u548c\u9ad8\u5c3f\u9178\u8840\u75c7\u4eba\u7fa4\u5de8\u5927\uff0c\u591a\u9879\u6d41\u884c\u75c5\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u4e0e\u75db\u98ce\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80be\u810f\u75be\u75c5\u3001\u4ee3\u8c22\u7efc\u5408\u5f81\u7b49\u75be\u75c5\u7684\u53d1\u751f\u3001\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\u3002\u73b0\u6709\u4e3b\u8981XOI\u6291\u5236\u5242\u975e\u5e03\u53f8\u4ed6\uff08Febuxostat\uff09\u5b58\u5728\u6f5c\u5728\u7684\u5fc3\u8840\u7ba1\u98ce\u9669\u3001\u522b\u560c\u9187\uff08Allopurinol\uff09\u5b58\u5728\u4e9a\u6d32\u4eba\u8d85\u654f\u53cd\u5e94\u53d1\u751f\u7387\u9ad8\u7b49\u660e\u663e\u95ee\u9898\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u76ee\u524d\u4ecd\u5b58\u5728\u7740\u663e\u8457\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u3002<\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u603b\u88c1\u5218\u52c7\u519b\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u4e0eLG\u5316\u5b66\u8fbe\u6210Tigulixostat\u7684\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u5408\u4f5c\u3002\u75db\u98ce\u53ca\u9ad8\u5c3f\u9178\u8840\u75c7\u65e2\u5c5e\u4e8e\u98ce\u6e7f\u75be\u75c5\u53c8\u5c5e\u4e8e\u6162\u6027\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u4e0e\u4fe1\u8fbe\u751f\u7269\u75be\u75c5\u9886\u57df\u7684\u6218\u7565\u5e03\u5c40\u4ee5\u53ca\u6211\u4eec\u73b0\u6709\u7814\u53d1\u7ba1\u7ebf\u3001\u7814\u7a76\u8d44\u6e90\u9ad8\u5ea6\u5951\u5408\u3002\u4f5c\u4e3a\u5168\u7403\u4e3a\u6570\u4e0d\u591a\u9776\u5411XOI\u7684\u65b0\u4e00\u4ee3\u836f\u7269\uff0cTigulixostat\u5728\u4e0e\u975e\u5e03\u53f8\u4ed6\u5728\u4e8c\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u5c55\u793a\u51fa\u6bd4\u975e\u5e03\u53f8\u4ed6\u66f4\u597d\u7684\u7597\u6548\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u663e\u793a\u51faTigulixostat Best-in-Class\uff08\u540c\u7c7b\u6700\u4f18\uff09\u4ea7\u54c1\u7684\u6f5c\u529b\u3002\u57fa\u4e8e\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u548c\u624e\u5b9e\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u6211\u4eec\u5c06\u5feb\u901f\u63a8\u8fdbTigulixostat\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u529b\u4e89\u5c06\u8fd9\u4e00\u5168\u65b0\u7684XOI\u65b0\u4e00\u4ee3\u4ea7\u54c1\u5c3d\u5feb\u5e26\u7ed9\u60a3\u8005\u3002\u201d<\/p>\n<p><b>LG<\/b><b>\u5316\u5b66\u751f\u547d\u79d1\u5b66\u603b\u88c1<\/b><b><span class=\"xn-person\">Jeewoong Son<\/span><\/b><b>\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201cTigulixostat\u6709\u671b\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u6210\u4e3a\u75db\u98ce\u60a3\u8005\u4e34\u5e8a\u6cbb\u7597\u7684\u66f4\u4f18\u9009\u62e9\uff0c\u6211\u4eec\u4e0e\u4fe1\u8fbe\u751f\u7269\u7684\u5408\u4f5c\u5c06\u52a0\u901fTigulixostat\u5728\u5168\u7403\u8303\u56f4\u7684\u7814\u53d1\u548c\u5546\u4e1a\u5316\uff0c\u4e3a\u5168\u7403\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u63d0\u4f9b\u9ad8\u4ef7\u503c\u6cbb\u7597\u65b9\u6848\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u5728\u6253\u9020LG\u5316\u5b66\u5168\u7403\u5316\u751f\u7269\u6280\u672f\u7814\u53d1\u80fd\u529b\u8fdb\u7a0b\u4e2d\u8fbe\u6210\u8fd9\u9879\u91cc\u7a0b\u7891\u5f0f\u7684\u6218\u7565\u5408\u4f5c\uff0c\u4ee5\u5145\u5206\u5f00\u53d1Tigulixostat\u7684\u6f5c\u529b\u3002\u6211\u4eec\u975e\u5e38\u671f\u5f85\u4e0e\u4fe1\u8fbe\u751f\u7269\u7684\u7d27\u5bc6\u5408\u4f5c\uff0c\u57fa\u4e8e\u53cc\u65b9\u5f3a\u5927\u5e7f\u6cdb\u7684\u7814\u53d1\u7ecf\u9a8c\u548c\u7814\u53d1\u5b9e\u529b\uff0c\u52a0\u901fTigulixostat\u7684\u5f00\u53d1\u8fdb\u7a0b\uff0c\u4e3a\u5168\u7403\u75db\u98ce\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u5e0c\u671b\u3002\u201c<\/p>\n<p><b>\u5173\u4e8e<\/b><b>Tigulixostat (LC350189<\/b><b>, IBI350)<\/b><\/p>\n<p>Tigulixostat\u662f\u4e00\u6b3e\u5168\u65b0\u7684\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff08XOI\uff0cxanthine oxidase inhibitor\uff09\uff0c\u901a\u8fc7\u6291\u5236\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6d3b\u6027\uff0c\u963b\u6b62\u6b21\u9ec4\u560c\u5464\u548c\u9ec4\u560c\u5464\u4ee3\u8c22\u4e3a\u5c3f\u9178\uff0c\u4ece\u800c\u51cf\u5c11\u5c3f\u9178\u751f\u6210\u3002Tigulixostat\u7ed3\u6784\u5f02\u4e8e\u5305\u62ec\u560c\u5464\u7c7b\u4f3c\u7269\u522b\u560c\u9187\u5728\u5185\u7684\u5176\u4ed6\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\u3002\u76ee\u524d\uff0cTigulixostat\u5728\u7f8e\u56fd\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u7684\u4e34\u5e8a2\u671f\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u964d\u8840\u6e05\u5c3f\u9178\u6c34\u5e73\uff08sUA\uff09\u4f5c\u7528\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>CLUE<\/b><b>\u7814\u7a76<\/b><\/p>\n<p>CLUE\u7814\u7a76\uff08NCT03934099\uff09\u4e8e2019\u5e746\u6708\u83b7FDA\u6279\u51c6\u5f00\u5c55\uff0c\u662f\u4e00\u9879\u7531LG\u5316\u5b66\u5f00\u5c55\u7684\u5173\u4e8eTigulixostat\u7684\u4e34\u5e8a2\u671f\u7814\u7a76\uff0c\u7814\u7a76\u5728\u7f8e\u56fd42\u4e2a\u8bd5\u9a8c\u4e2d\u5fc3\u5f00\u5c55\uff0c\u5171\u5165\u7ec4\u4e86156\u4f8b\u75db\u98ce\u60a3\u8005\u3002<\/p>\n<p>\u7814\u7a76\u53d7\u8bd5\u8005\u4e3a\u6162\u6027\u75db\u98ce\u60a3\u8005\uff0c\u4e34\u5e8a\u5b9a\u4e49\u4e3a\u9ad8\u5c3f\u9178\u8840\u75c7\u4f34\u6709\u75db\u98ce\u5386\u53f2\u6216\u6709\u75db\u98ce\u75c7\u72b6\uff08\u636eACR\u6807\u51c6\uff09\uff0c\u8840\u6e05\u5c3f\u9178\u6c34\u5e73\u2265 8 mg\/dL, \u226412 mg\/dL\u3002\u6cbb\u7597\u5468\u671f\u4e3a3\u4e2a\u6708\uff0c\u53d7\u8bd5\u8005\u53e3\u670dTigulixostat\uff0850mg,100mg\u548c200mg\uff09\u6216\u5b89\u6170\u5242\uff0c\u4e00\u65e5\u4e00\u6b21\uff0c\u6b64\u5916156\u4f8b\u53d7\u8bd5\u8005\u4e2d13\u4f8b\u5212\u5206\u4e3a\u5bf9\u7167\u7ec4\uff0c\u670d\u752840-80mg\u975e\u5e03\u53f8\u4ed6\uff0c\u4e00\u65e5\u4e00\u6b21\u3002<\/p>\n<p>\u7814\u7a76\u671f\u95f4\uff0c&nbsp;\u5411\u60a3\u8005\u5f00\u51770.6 mg\u79cb\u6c34\u4ed9\u78b1\uff08\u4e00\u65e5\u4e00\u6b21\uff09\u4ee5\u9884\u9632\u6025\u6027\u75db\u98ce\u53d1\u4f5c\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a3\u4e2a\u6708\u540e\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u81f3&lt; 5 mg\/dL\u7684\u8fbe\u6210\u7387\u3002<\/p>\n<p><b>CLUE <\/b><b>\u7814\u7a76\u7684\u7814\u7a76\u7ed3\u679c<\/b><b>:<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5b9e\u9a8c\u7ec4\u4e2d\uff0c\u9996\u8981\u7814\u7a76\u7ec8\u70b93\u4e2a\u6708\u540e\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u81f3&lt; 5 mg\/dL\u7684\u8fbe\u6210\u7387\uff0c50mg Tigulixostat\u5242\u91cf\u7ec4\u4e3a 47%\uff0816\/34\uff09\uff0c100mg Tigulixostat\u5242\u91cf\u7ec4\u4e3a45% \uff0817\/38\uff09\uff0c200mg Tigulixostat\u5242\u91cf\u7ec4\u4e3a62% \uff0823\/37\uff09\u3002\u4f7f\u7528\u975e\u5e03\u53f8\u4ed6\u7684\u8fbe\u6210\u7387\u4e3a23% \uff083\/13\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a3% \uff081\/34\uff09\u3002<\/li>\n<li>\u5b9e\u9a8c\u7ec4\u4e2d\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b93\u4e2a\u6708\u540e\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u81f3&lt; 6 mg\/dL\u7684\u8fbe\u6210\u7387\uff0c50mg Tigulixostat\u5242\u91cf\u7ec4\u3001100mg Tigulixostat\u5242\u91cf\u7ec4\u548c200mg Tigulixostat\u5242\u91cf\u7ec4\u5206\u522b\u4e3a59%, 63%, 78%\u3002\u4f7f\u7528\u975e\u5e03\u53f8\u4ed6\u8fbe\u6210\u7387\u4e3a54%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a3%\u3002<\/li>\n<li>\u5728\u6cbb\u75972\u5468\u65f6\u95f4\u5185\uff0cTigulixostat\u5728\u6240\u6709\u5242\u91cf\u7ec4\u4e2d\u90fd\u5c55\u73b0\u51fa\u4e86\u5f3a\u5242\u91cf\u76f8\u5173\u7684\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u7684\u6709\u6548\u6027\uff0c\u5e76\u5728\u6574\u4e2a\u6cbb\u7597\u5468\u671f\u5185\u7ef4\u6301\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u3002<\/li>\n<li>\u4e0e\u5b89\u6170\u5242\u7ec4\u5bf9\u6bd4\uff0cTigulixostat\u5728\u6240\u6709\u5242\u91cf\u7ec4\u4e2d\u540c\u6837\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u3002Tigulixostat\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u95f4\u65e0\u6cbb\u7597\u671f\u95f4\u53d1\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TATE\uff09\u603b\u53d1\u751f\u7387\u7684\u663e\u8457\u5dee\u5f02\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e<\/b><b>LG<\/b><b>\u5316\u5b66<\/b>&nbsp;LG\u5316\u5b66\u662f\u5168\u7403\u9886\u5148\u7684\u5316\u5de5\u4f01\u4e1a\uff0c\u5728\u77f3\u6cb9\u5316\u5de5\u3001\u5148\u8fdb\u6750\u6599\u548c\u751f\u547d\u79d1\u5b66\u7b49\u5173\u952e\u9886\u57df\u62e5\u6709\u591a\u5143\u5316\u7684\u4e1a\u52a1\u7ec4\u5408\u3002\u516c\u53f8\u751f\u4ea7\u4ece\u9ad8\u9644\u52a0\u503c\u7684\u77f3\u5316\u4ea7\u54c1\u5230\u53ef\u518d\u751f\u5851\u6599\u7684\u5e7f\u6cdb\u4ea7\u54c1\uff0c\u4e13\u6ce8\u4e8e\u5c16\u7aef\u7535\u5b50\u548c\u7535\u6c60\u6750\u6599\uff0c\u4ee5\u53ca\u836f\u7269\u548c\u75ab\u82d7\uff0c\u4e3a\u5ba2\u6237\u63d0\u4f9b\u5dee\u5f02\u5316\u7684\u89e3\u51b3\u65b9\u6848\u3002LG\u5316\u5b66\u751f\u547d\u79d1\u5b66\u662fLG\u5316\u5b66\u56db\u5927\u4e8b\u4e1a\u4e2d\u5fc3\u4e4b\u4e00\uff0c\u81f4\u529b\u4e8e\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u9500\u552e\u533b\u836f\u4ea7\u54c1\uff0c\u4e13\u6ce8\u4e8e\u514d\u75ab\u3001\u80bf\u7624\u3001\u4ee3\u8c22\uff08\u7cd6\u5c3f\u75c5\u76f8\u5173\uff09\u75be\u75c5\u9886\u57df\uff0c\u4ee5\u6269\u5927\u5168\u7403\u5f71\u54cd\u529b\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.lgchem.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.lgchem.com<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec35\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u3002\u516c\u53f8\u5df2\u6709&nbsp;8\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT&reg;\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA &reg;\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO &reg;\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA&reg;; \u4f69\u7c73\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE&reg;; \u5965\u96f7\u5df4\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b&reg;; \u96f7\u83ab\u897f\u5c24\u5355\u6297\uff0c\u5546\u54c1\u540d\uff1a\u5e0c\u5189\u62e9&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aCYRAMZA&reg;; \u585e\u666e\u66ff\u5c3c\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c&nbsp;2\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c5\u4e2a\u54c1\u79cd\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670920\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001\u8d5b\u8bfa\u83f2\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n<p>\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7\uff1aInnovent Biologics\u3002<\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u201c\u9884\u671f\u201d\u3001\u201c\u76f8\u4fe1\u201d\u3001\u201c\u9884\u6d4b\u201d\u3001\u201c\u671f\u671b\u201d\u3001\u201c\u6253\u7b97\u201d\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<div>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]&nbsp;LG Chem announces topline results of LC350189 from the Phase 2 Study (Clue Study) promising to be a new treatment alternative with improved efficacy and safety profiles for chronic gout patients (2021)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[2]&nbsp;Terkeltaub, R. (2021) Phase 2 study results from a randomized, double-blind, placebo-controlled, dose-finding study to evaluate efficacy and safety of TIGULIXOSTAT, a novel non-purine selective xanthine oxidase inhibitor, in gout patients with hyperuricemia, ACR Meeting Abstracts.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[3]&nbsp;Guideline for the diagnosis and management of hyperuricemia and gout in China(2019)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14, \u4e2d\u56fd\u82cf\u5dde\u548c\u97e9\u56fd\u9996\u5c142022\u5e7412\u670815\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e0eLG\u5316\u5b66\u65d7\u4e0b\u7684LG\u5316\u5b66\u751f\u547d\u79d1\u5b66\uff08\u4e0b\u79f0\u201cLG\u5316\u5b66\u201d\uff09\uff0c\u5ba3\u5e03\u53cc\u65b9\u5c31\u7531LG\u5316\u5b66\u7814\u53d1\u7684\u4e34\u5e8a\u540e\u671f\u521b\u65b0\u836f\u7269Tigulixostat\uff08LG\u7814\u53d1\u4ee3\u53f7: LC350189, \u4fe1\u8fbe\u751f\u7269\u7814\u53d1\u4ee3\u53f7: IBI350\uff09\u2014\u2014\u4e00\u6b3e\u6cbb\u7597\u75db\u98ce\u60a3\u8005\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u5168\u65b0\u975e\u560c\u5464\u7c7b\u4f3c\u7269\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff08XOI\uff09\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002 \u5728\u4e00\u9879\u4e8e\u7f8e\u56fd\u5b8c\u6210\u76842\u671f\u4e34\u5e8a\u7814\u7a76\uff08CLUE\u7814\u7a76\uff09\u4e2d\uff0cTigulixostat\u5728\u6240\u6709\u5242\u91cf\u7ec4\u5747\u5c55\u73b0\u51fa\u826f\u597d\u7684\u964d\u8840\u5c3f\u9178\u6c34\u5e73\uff08sUA\uff09\u4f5c\u7528\uff0c\u5e76\u4e14\u548c\u5b89\u6170\u5242\u53ca\u975e\u5e03\u53f8\u4ed6\uff08Febuxostat\uff09\u76f8\u6bd4\uff0cTigulixostat\u5728\u6cbb\u75973\u4e2a\u6708\u540e\u6240\u6709\u5242\u91cf\u7ec4\u5747\u8fbe\u5230\u4e86sUA&lt;5mg\/dL\u7684\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9[1],[2]\u3002LG\u5316\u5b66\u5df2\u4e8e2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u542f\u52a8Tigulixostat\u7684\u56fd\u9645\u591a\u4e2d\u5fc33\u671f\u4e34\u5e8a\u7814\u7a76\u3002 \u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4fe1\u8fbe\u751f\u7269\u5c06\u83b7\u5f97Tigulixostat\u5728\u4e2d\u56fd\u7684\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002LG\u5316\u5b66\u5c06\u83b7\u5f971,000\u4e07\u7f8e\u91d1\u7684\u5408\u4f5c\u9996\u4ed8\u6b3e\uff0c\u5e76\u5c06\u6709\u8d44\u683c\u83b7\u5f97\u603b\u989d\u4e0d\u8d85\u8fc78,550\u4e07\u7f8e\u91d1\u7684\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u57fa\u4e8e\u4e2d\u56fd\u5730\u533a\u5e74\u5ea6\u51c0\u9500\u552e\u989d\u7684\u68af\u5ea6\u7279\u8bb8\u4f7f\u7528\u8d39\u3002 \u9ad8\u5c3f\u9178\u8840\u75c7\u5df2\u6210\u4e3a\u7ee7\u9ad8\u8840\u538b\u3001\u9ad8\u8840\u8102\u3001\u9ad8\u8840\u7cd6\u201c\u4e09\u9ad8\u201d\u4e4b\u540e\u7684\u201c\u7b2c\u56db\u9ad8\u201d\u3002\u4e2d\u56fd\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u75c5\u7387\u7ea613.3% \uff081.87\u4ebf\u4eba\uff09[3]\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u662f\u5bfc\u81f4\u75db\u98ce\u75c5\u7684\u5148\u51b3\u6761\u4ef6\uff0c\u5728\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u4e2d\u75db\u98ce\u4eba\u7fa4\u7ea6\u4e3a1550\u4e07\u3002\u6d77\u5185\u5916\u75db\u98ce\u548c\u9ad8\u5c3f\u9178\u8840\u75c7\u4eba\u7fa4\u5de8\u5927\uff0c\u591a\u9879\u6d41\u884c\u75c5\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u4e0e\u75db\u98ce\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80be\u810f\u75be\u75c5\u3001\u4ee3\u8c22\u7efc\u5408\u5f81\u7b49\u75be\u75c5\u7684\u53d1\u751f\u3001\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\u3002\u73b0\u6709\u4e3b\u8981XOI\u6291\u5236\u5242\u975e\u5e03\u53f8\u4ed6\uff08Febuxostat\uff09\u5b58\u5728\u6f5c\u5728\u7684\u5fc3\u8840\u7ba1\u98ce\u9669\u3001\u522b\u560c\u9187\uff08Allopurinol\uff09\u5b58\u5728\u4e9a\u6d32\u4eba\u8d85\u654f\u53cd\u5e94\u53d1\u751f\u7387\u9ad8\u7b49\u660e\u663e\u95ee\u9898\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\u76ee\u524d\u4ecd\u5b58\u5728\u7740\u663e\u8457\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u3002 \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u603b\u88c1\u5218\u52c7\u519b\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u4e0eLG\u5316\u5b66\u8fbe\u6210Tigulixostat\u7684\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u5408\u4f5c\u3002\u75db\u98ce\u53ca\u9ad8\u5c3f\u9178\u8840\u75c7\u65e2\u5c5e\u4e8e\u98ce\u6e7f\u75be\u75c5\u53c8\u5c5e\u4e8e\u6162\u6027\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u4e0e\u4fe1\u8fbe\u751f\u7269\u75be\u75c5\u9886\u57df\u7684\u6218\u7565\u5e03\u5c40\u4ee5\u53ca\u6211\u4eec\u73b0\u6709\u7814\u53d1\u7ba1\u7ebf\u3001\u7814\u7a76\u8d44\u6e90\u9ad8\u5ea6\u5951\u5408\u3002\u4f5c\u4e3a\u5168\u7403\u4e3a\u6570\u4e0d\u591a\u9776\u5411XOI\u7684\u65b0\u4e00\u4ee3\u836f\u7269\uff0cTigulixostat\u5728\u4e0e\u975e\u5e03\u53f8\u4ed6\u5728\u4e8c\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u5c55\u793a\u51fa\u6bd4\u975e\u5e03\u53f8\u4ed6\u66f4\u597d\u7684\u7597\u6548\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u663e\u793a\u51faTigulixostat Best-in-Class\uff08\u540c\u7c7b\u6700\u4f18\uff09\u4ea7\u54c1\u7684\u6f5c\u529b\u3002\u57fa\u4e8e\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u548c\u624e\u5b9e\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u6211\u4eec\u5c06\u5feb\u901f\u63a8\u8fdbTigulixostat\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u529b\u4e89\u5c06\u8fd9\u4e00\u5168\u65b0\u7684XOI\u65b0\u4e00\u4ee3\u4ea7\u54c1\u5c3d\u5feb\u5e26\u7ed9\u60a3\u8005\u3002\u201d LG\u5316\u5b66\u751f\u547d\u79d1\u5b66\u603b\u88c1Jeewoong Son\u535a\u58eb\u8868\u793a\uff1a\u201cTigulixostat\u6709\u671b\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u6210\u4e3a\u75db\u98ce\u60a3\u8005\u4e34\u5e8a\u6cbb\u7597\u7684\u66f4\u4f18\u9009\u62e9\uff0c\u6211\u4eec\u4e0e\u4fe1\u8fbe\u751f\u7269\u7684\u5408\u4f5c\u5c06\u52a0\u901fTigulixostat\u5728\u5168\u7403\u8303\u56f4\u7684\u7814\u53d1\u548c\u5546\u4e1a\u5316\uff0c\u4e3a\u5168\u7403\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u63d0\u4f9b\u9ad8\u4ef7\u503c\u6cbb\u7597\u65b9\u6848\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u5728\u6253\u9020LG\u5316\u5b66\u5168\u7403\u5316\u751f\u7269\u6280\u672f\u7814\u53d1\u80fd\u529b\u8fdb\u7a0b\u4e2d\u8fbe\u6210\u8fd9\u9879\u91cc\u7a0b\u7891\u5f0f\u7684\u6218\u7565\u5408\u4f5c\uff0c\u4ee5\u5145\u5206\u5f00\u53d1Tigulixostat\u7684\u6f5c\u529b\u3002\u6211\u4eec\u975e\u5e38\u671f\u5f85\u4e0e\u4fe1\u8fbe\u751f\u7269\u7684\u7d27\u5bc6\u5408\u4f5c\uff0c\u57fa\u4e8e\u53cc\u65b9\u5f3a\u5927\u5e7f\u6cdb\u7684\u7814\u53d1\u7ecf\u9a8c\u548c\u7814\u53d1\u5b9e\u529b\uff0c\u52a0\u901fTigulixostat\u7684\u5f00\u53d1\u8fdb\u7a0b\uff0c\u4e3a\u5168\u7403\u75db\u98ce\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u5e0c\u671b\u3002\u201c \u5173\u4e8eTigulixostat (LC350189, IBI350) Tigulixostat\u662f\u4e00\u6b3e\u5168\u65b0\u7684\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff08XOI\uff0cxanthine oxidase inhibitor\uff09\uff0c\u901a\u8fc7\u6291\u5236\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6d3b\u6027\uff0c\u963b\u6b62\u6b21\u9ec4\u560c\u5464\u548c\u9ec4\u560c\u5464\u4ee3\u8c22\u4e3a\u5c3f\u9178\uff0c\u4ece\u800c\u51cf\u5c11\u5c3f\u9178\u751f\u6210\u3002Tigulixostat\u7ed3\u6784\u5f02\u4e8e\u5305\u62ec\u560c\u5464\u7c7b\u4f3c\u7269\u522b\u560c\u9187\u5728\u5185\u7684\u5176\u4ed6\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\u3002\u76ee\u524d\uff0cTigulixostat\u5728\u7f8e\u56fd\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u7684\u4e34\u5e8a2\u671f\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u964d\u8840\u6e05\u5c3f\u9178\u6c34\u5e73\uff08sUA\uff09\u4f5c\u7528\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002 \u5173\u4e8eCLUE\u7814\u7a76 CLUE\u7814\u7a76\uff08NCT03934099\uff09\u4e8e2019\u5e746\u6708\u83b7FDA\u6279\u51c6\u5f00\u5c55\uff0c\u662f\u4e00\u9879\u7531LG\u5316\u5b66\u5f00\u5c55\u7684\u5173\u4e8eTigulixostat\u7684\u4e34\u5e8a2\u671f\u7814\u7a76\uff0c\u7814\u7a76\u5728\u7f8e\u56fd42\u4e2a\u8bd5\u9a8c\u4e2d\u5fc3\u5f00\u5c55\uff0c\u5171\u5165\u7ec4\u4e86156\u4f8b\u75db\u98ce\u60a3\u8005\u3002 \u7814\u7a76\u53d7\u8bd5\u8005\u4e3a\u6162\u6027\u75db\u98ce\u60a3\u8005\uff0c\u4e34\u5e8a\u5b9a\u4e49\u4e3a\u9ad8\u5c3f\u9178\u8840\u75c7\u4f34\u6709\u75db\u98ce\u5386\u53f2\u6216\u6709\u75db\u98ce\u75c7\u72b6\uff08\u636eACR\u6807\u51c6\uff09\uff0c\u8840\u6e05\u5c3f\u9178\u6c34\u5e73\u2265 8 mg\/dL, \u226412 mg\/dL\u3002\u6cbb\u7597\u5468\u671f\u4e3a3\u4e2a\u6708\uff0c\u53d7\u8bd5\u8005\u53e3\u670dTigulixostat\uff0850mg,100mg\u548c200mg\uff09\u6216\u5b89\u6170\u5242\uff0c\u4e00\u65e5\u4e00\u6b21\uff0c\u6b64\u5916156\u4f8b\u53d7\u8bd5\u8005\u4e2d13\u4f8b\u5212\u5206\u4e3a\u5bf9\u7167\u7ec4\uff0c\u670d\u752840-80mg\u975e\u5e03\u53f8\u4ed6\uff0c\u4e00\u65e5\u4e00\u6b21\u3002 \u7814\u7a76\u671f\u95f4\uff0c&nbsp;\u5411\u60a3\u8005\u5f00\u51770.6 mg\u79cb\u6c34\u4ed9\u78b1\uff08\u4e00\u65e5\u4e00\u6b21\uff09\u4ee5\u9884\u9632\u6025\u6027\u75db\u98ce\u53d1\u4f5c\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a3\u4e2a\u6708\u540e\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u81f3&lt; 5 mg\/dL\u7684\u8fbe\u6210\u7387\u3002 CLUE \u7814\u7a76\u7684\u7814\u7a76\u7ed3\u679c: \u5b9e\u9a8c\u7ec4\u4e2d\uff0c\u9996\u8981\u7814\u7a76\u7ec8\u70b93\u4e2a\u6708\u540e\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u81f3&lt; 5 mg\/dL\u7684\u8fbe\u6210\u7387\uff0c50mg Tigulixostat\u5242\u91cf\u7ec4\u4e3a 47%\uff0816\/34\uff09\uff0c100mg Tigulixostat\u5242\u91cf\u7ec4\u4e3a45% \uff0817\/38\uff09\uff0c200mg Tigulixostat\u5242\u91cf\u7ec4\u4e3a62% \uff0823\/37\uff09\u3002\u4f7f\u7528\u975e\u5e03\u53f8\u4ed6\u7684\u8fbe\u6210\u7387\u4e3a23% \uff083\/13\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a3% \uff081\/34\uff09\u3002 \u5b9e\u9a8c\u7ec4\u4e2d\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b93\u4e2a\u6708\u540e\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u81f3&lt; 6 mg\/dL\u7684\u8fbe\u6210\u7387\uff0c50mg Tigulixostat\u5242\u91cf\u7ec4\u3001100mg Tigulixostat\u5242\u91cf\u7ec4\u548c200mg Tigulixostat\u5242\u91cf\u7ec4\u5206\u522b\u4e3a59%, 63%, 78%\u3002\u4f7f\u7528\u975e\u5e03\u53f8\u4ed6\u8fbe\u6210\u7387\u4e3a54%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a3%\u3002 \u5728\u6cbb\u75972\u5468\u65f6\u95f4\u5185\uff0cTigulixostat\u5728\u6240\u6709\u5242\u91cf\u7ec4\u4e2d\u90fd\u5c55\u73b0\u51fa\u4e86\u5f3a\u5242\u91cf\u76f8\u5173\u7684\u964d\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u7684\u6709\u6548\u6027\uff0c\u5e76\u5728\u6574\u4e2a\u6cbb\u7597\u5468\u671f\u5185\u7ef4\u6301\u8840\u6e05\u5c3f\u9178\uff08sUA\uff09\u6c34\u5e73\u3002 \u4e0e\u5b89\u6170\u5242\u7ec4\u5bf9\u6bd4\uff0cTigulixostat\u5728\u6240\u6709\u5242\u91cf\u7ec4\u4e2d\u540c\u6837\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u3002Tigulixostat\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u95f4\u65e0\u6cbb\u7597\u671f\u95f4\u53d1\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TATE\uff09\u603b\u53d1\u751f\u7387\u7684\u663e\u8457\u5dee\u5f02\u3002&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022121507000087960\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":0,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-87960","post","type-post","status-publish","format-standard","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/87960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=87960"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/87960\/revisions"}],"predecessor-version":[{"id":87961,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/87960\/revisions\/87961"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=87960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=87960"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=87960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}