{"id":87951,"date":"2022-12-14T21:30:00","date_gmt":"2022-12-14T14:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121421300087951"},"modified":"2022-12-15T22:14:06","modified_gmt":"2022-12-15T14:14:06","slug":"%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e7%bd%95%e8%a7%81%e7%9a%ae%e8%82%a4%e7%97%85%e9%9d%b6%e5%90%91%e7%94%9f%e7%89%a9%e5%88%b6%e5%89%82%e5%9c%a3%e5%88%a9%e5%8d%93r%e5%9c%a8","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121421300087951","title":{"rendered":"\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7f55\u89c1\u76ae\u80a4\u75c5\u9776\u5411\u751f\u7269\u5236\u5242\u5723\u5229\u5353(R)\u5728\u534e\u83b7\u6279"},"content":{"rendered":"<p><p><b><span id=\"spanHghlt2571\">\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6cdb<\/span>\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\u53d1\u4f5c <\/b><\/p>\n<p><b><span id=\"spanHghltd2e5\">\u5168\u7403<\/span>\u540c\u6b65\u83b7\u6279\uff0c\u96f6\u65f6\u5dee\u60e0\u53ca\u4e2d\u56fd\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\u60a3\u8005<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5723\u5229\u5353<sup>&reg;<\/sup>\uff08\u4f69\u7d22\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u662f\u540c<span id=\"spanHghlt5f6f\">\u7c7b\u9996\u4e2a<\/span>\u963b\u65ad\u767d\u4ecb\u7d20-36\u53d7\u4f53 (IL-36R)\u6fc0\u6d3b\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u6291\u5236IL-36\u7684\u4fe1\u53f7\u4f20\u5bfc\uff0c\u4e5f\u662f<span id=\"spanHghlt4415\">\u56fd\u5185\u9996\u4e2a<\/span>\u83b7\u6279\u4e13\u95e8\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\uff08GPP\uff09\u53d1\u4f5c\u7684\u6cbb\u7597\u836f\u7269\uff1b<\/li>\n<li>Effisayil<sup>TM<\/sup> 1 II\u671f\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u7ecf\u5723\u5229\u5353<sup>&reg;<\/sup>\u6cbb\u75971\u5468\u540e\uff0c54.3%\u7684\u60a3\u8005\u8fbe\u5230\u76ae\u80a4\u65e0\u53ef\u89c1\u8113\u75b1\uff1b42.9%\u7684\u60a3\u8005\u53ef\u8fbe\u5230\u76ae\u80a4\u75c7\u72b6\u6e05\u9664\u6216\u51e0\u4e4e\u6e05\u9664\uff1b<\/li>\n<li>\u5723\u5229\u5353<sup>&reg;<\/sup>\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u8d44\u683c\uff0c\u4e14\u5b9e\u73b0\u4e86\u5168\u7403\u540c\u6b65\u7814\u53d1\u3001\u540c\u6b65\u6ce8\u518c\u3001\u540c\u6b65\u83b7\u6279\u3002<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2022\u5e7412\u670814\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4eca\u65e5\u5ba3\u5e03\uff0c<b>\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u6279\u51c6\u516c\u53f8\u7f55\u89c1\u76ae\u80a4\u75c5\u521b\u65b0\u836f\u5723\u5229\u5353<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u901a\u7528\u540d\uff1a\u4f69\u7d22\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\uff08<\/b><b>Generalized Pustular Psoriasis\uff0c\u7b80\u79f0GPP\uff09\u53d1\u4f5c\u3002<\/b>\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5723\u5229\u5353<sup>&reg;<\/sup>\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u8d44\u683c\uff0c\u4e14\u4e0e\u5168\u7403\u540c\u6b65\u7814\u53d1\u3001\u540c\u6b65\u6ce8\u518c\u3001\u540c\u6b65\u83b7\u6279\uff08\u4ec5\u665a\u4e8e\u7f8e\u56fd\u83b7\u6279\u4e09\u4e2a\u6708\uff09\uff0c\u771f\u6b63\u5b9e\u73b0\u4e86\u96f6\u65f6\u5dee\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005\u3002<\/p>\n<p>\u5723\u5229\u5353<sup>&reg;<\/sup>\u662f<span id=\"spanHghlt16a0\">\u540c\u7c7b\u9996\u4e2a<\/span>\u963b\u65adIL-36\u53d7\u4f53\u6fc0\u6d3b\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u586b\u8865\u4e86\u8be5\u75be\u75c5\u9886\u57df\u957f\u671f\u4ee5\u6765\u5de8\u5927\u7684\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u53ef\u4ee5\u5feb\u901f\u3001\u6709\u6548\u3001\u6301\u4e45\u5730\u6e05\u9664GPP\u53d1\u4f5c\u51fa\u73b0\u7684\u8113\u75b1\u548c\u76ae\u635f\uff0c\u4ece\u800c\u6539\u5584\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u3002<\/p>\n<p><b>\u7cbe\u51c6\u9776\u5411\u521b\u65b0\u673a\u5236\uff0c\u5feb\u901f\u63a7\u5236<\/b><b>GPP\u53d1\u4f5c<\/b><\/p>\n<p>\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\uff08GPP\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u3001\u590d\u53d1\u6027\u6216\u6301\u7eed\u53d1\u4f5c\u7684\u76ae\u80a4\u75be\u75c5<span id=\"spanHghlt6e98\"><sup>[1]<\/sup><\/span><sup><span id=\"spanHghltb78a\">,[2]<\/span><\/sup>\u3002<span id=\"spanHghlt4d9d\">\u5728\u4e2d\u56fd<\/span>\u7ea6100,000\u4eba\u4e2d\u67091~2\u4eba\u60a3GPP<sup><span id=\"spanHghltfbe8\">[3]<\/span><\/sup>\u3002\u4e0e\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u4e0d\u540c\uff0cGPP\u7684\u4e34\u5e8a\u8868\u73b0\u4e3a\u60a3\u8005\u76ae\u80a4\u4f1a\u5e7f\u6cdb\u7206\u53d1\u5145\u6ee1\u8113\u6db2\u7684\u6c34\u6ce1\uff08\u8113\u75b1\uff09\uff0c\u5e76\u6709\u75db\u611f\uff0c\u800c\u4e14\u53ef\u80fd\u4f34\u53d1\u9ad8\u70ed\u7b49\u5168\u8eab\u75c7\u72b6\u3002\u540c\u65f6\uff0cGPP\u53ef\u53cd\u590d\u53d1\u4f5c\uff0c\u4e5f\u53ef\u5448\u6301\u7eed\u6027\u53d1\u75c5, \u5e76\u4f34\u53d1\u809d\u80be\u635f\u5bb3\uff0c\u4e5f\u53ef\u56e0\u7ee7\u53d1\u611f\u67d3\u3001\u5668\u5b98\u529f\u80fd\u8870\u7aed\u800c\u5371\u53ca\u751f\u547d\u3002<\/p>\n<p>\u8fd9\u4e9b\u201c\u53cd\u590d\u65e0\u5e38\u201d\u3001\u201c\u7f20\u7f20\u7ef5\u7ef5\u201d\u7684\u75c5\u75c7\u4e0d\u4ec5\u5f71\u54cd\u7740\u60a3\u8005\u7684\u8eab\u4f53\u5065\u5eb7\uff0c\u4e5f\u7ed9\u60a3\u8005\u5e26\u6765\u4e86\u6c89\u91cd\u7684\u5fc3\u7406\u8d1f\u62c5 &#8212; \u56e0\u5bb9\u8c8c\u635f\u5bb3\u5f80\u5f80\u611f\u5230\u81ea\u5351\u5b64\u72ec\uff0c\u4ee5\u53ca\u5bf9\u590d\u53d1\u7684\u6050\u60e7\u548c\u7126\u8651\u3002\u66fe\u6709\u60a3\u8005\u8868\u793a\uff0cGPP\u53d1\u4f5c\u65f6\u5bfc\u81f4\u7684\u5168\u8eab\u6e83\u70c2\uff0c\u8fde\u6d17\u6fa1\u90fd\u5341\u5206\u75db\u82e6\uff0c\u7b49\u8113\u75b1\u892a\u75c2\u65f6\uff0c\u56e0\u4e3a\u5267\u70c8\u7684\u75d2\uff0c\u53ea\u80fd\u7528\u62f3\u5934\u7838\u8eab\u4e0a\uff0c\u7528\u75db\u76d6\u8fc7\u75d2\uff0c\u4e00\u4e2a\u6b63\u5e38\u7684\u7761\u7720\u90fd\u662f\u5962\u4f88\u3002<\/p>\n<p>\u5723\u5229\u5353<sup>&reg;<\/sup>\u662f\u4e00\u79cd\u9776\u5411\u4f5c\u7528\u4e8eIL-36\u53d7\u4f53\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0cIL-36\u4fe1\u53f7\u901a\u8def\u4e0eGPP\u7684\u53d1\u75c5\u673a\u5236\u5bc6\u5207\u76f8\u5173\uff0cIL-36\u662f\u5bfc\u81f4\u708e\u75c7\u5faa\u73af\u3001\u76ae\u80a4\u708e\u75c7\u3001\u8113\u75b1\u5f62\u6210\u548c\u5f02\u5e38\u7ec4\u7ec7\u91cd\u6784\u7684\u4e3b\u8981\u7ec6\u80de\u56e0\u5b50\u3002\u5723\u5229\u5353<sup>&reg;<\/sup>\u901a\u8fc7\u4e0eIL-36\u53d7\u4f53\u7ed3\u5408\uff0c\u963b\u65adIL-36\u4ea7\u751f\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u4ece\u800c\u6291\u5236GPP\u7684\u708e\u75c7\u4fe1\u53f7\u901a\u8def\uff0c\u5b9e\u73b0\u8113\u75b1\u548c\u76ae\u635f\u7684\u5feb\u901f\u6e05\u9664\u3002\u4eca\u5e743\u6708\u300a\u8113\u75b1\u578b\u94f6\u5c51\u75c5\u8bca\u7597\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6\uff082022\u7248\uff09\u300b\u53d1\u5e03\uff0c\u5c06\u5c1a\u672a\u4e0a\u5e02\u7684\u5723\u5229\u5353<sup>&reg;<\/sup>\u5217\u5165\u63a8\u8350\uff0c\u4ee5\u671f\u5f85\u8fd9\u4e00\u65b0\u836f\u80fd\u591f\u586b\u8865\u76ee\u524d\u836f\u7269\u65e0\u6cd5\u6ee1\u8db3\u7684\u4e34\u5e8a\u6cbb\u7597\u9700\u6c42\u3002<\/p>\n<p><b>\u5168\u7403\u540c\u6b65\u83b7\u6279\uff0c\u96f6\u65f6\u5dee\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005 <\/b><\/p>\n<p>\u5723\u5229\u5353<sup>&reg;<\/sup>\u7684\u83b7\u6279\u662f\u57fa\u4e8e\u5176\u5168\u7403\u5173\u952e\u6027Effisayil<sup>TM<\/sup> 1 II\u671f\u4e34\u5e8a\u7814\u7a76<sup><span id=\"spanHghltd438\">[4]<\/span><\/sup>\u3002\u8be5\u7814\u7a76\u662f<span id=\"spanHghlt5ff1\">\u5168\u7403\u9996\u9879<\/span>\u9488\u5bf9GPP\u53d1\u4f5c\u60a3\u8005\u8fdb\u884c\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff0c\u8986\u76d6\u4e86\u5168\u740312\u4e2a\u56fd\u5bb6\/\u5730\u533a\uff0c\u5305\u62ec\u4e2d\u56fd\u3002\u7814\u7a76\u8868\u660e\uff1a<b>54.3%\u7684\u60a3\u8005\u7ecf\u5723\u5229\u5353<sup>&reg;<\/sup>\u6cbb\u75971\u5468\u4fbf\u8fbe\u5230\u76ae\u80a4\u65e0\u53ef\u89c1\u8113\u75b1\uff1b42.9%\u7684\u60a3\u8005\u7ecf\u5723\u5229\u5353<sup>&reg;<\/sup>\u6cbb\u75971\u5468\u53ef\u8fbe\u5230\u76ae\u80a4\u75c7\u72b6\u6e05\u9664\u6216\u51e0\u4e4e\u6e05\u9664<\/b><sup><span id=\"spanHghlt5ffe\">[4]<\/span><\/sup><b>\u3002<\/b>\u540c\u65f6\u5728\u6574\u4e2a\u7814\u7a76\u4e2d\uff0c\u5723\u5229\u5353<sup>&reg;<\/sup>\u7684\u5b89\u5168\u6027\u6570\u636e\u662f\u53ef\u63a5\u53d7\u7684\uff0c\u60a3\u8005\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u53d1\u70ed\u548c\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u611f\u67d3\u3002<\/p>\n<p><b>\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u534e\u5c71\u533b\u9662\u76ae\u80a4\u79d1\u4e3b\u4efb\u3001<\/b><b>Effisayil<sup>TM<\/sup> 1 II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u56fd\u9996\u5e2d\u7814\u7a76\u8005\u5f90\u91d1\u534e\u6559\u6388<\/b>\u8868\u793a\uff1a\u201c\u4f5c\u4e3a\u540c\u7c7b\u9996\u4e2a\u963b\u65adIL-36\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u5723\u5229\u5353&reg;\u7684\u83b7\u6279\u5728\u6211\u56fd\u4e43\u81f3\u5168\u7403GPP\u8bca\u7597\u53d1\u5c55\u5386\u7a0b\u4e2d\u5177\u6709\u7a81\u7834\u6027\u610f\u4e49\u3002\u5bf9\u4e8eGPP\u53d1\u4f5c\u60a3\u8005\u6765\u8bf4\uff0c\u6700\u4e3b\u8981\u7684\u8bc9\u6c42\u5c31\u662f\u63a7\u5236\u4e25\u91cd\u7684\u76ae\u80a4\u8113\u75b1\u548c\u5168\u8eab\u75c7\u72b6\uff0c\u5723\u5229\u5353<sup>&reg;<\/sup>\u80fd\u5e2e\u52a9GPP\u60a3\u8005\u5feb\u901f\u63a7\u5236\u76ae\u80a4\u8113\u75b1\uff0c\u4ee5\u52a9\u60a3\u8005\u5c3d\u5feb\u6446\u8131\u96be\u4ee5\u5fcd\u53d7\u7684\u76ae\u635f\u548c\u75db\u75d2\uff0c\u6781\u5927\u5730\u6539\u5584\u8fd9\u7c7b\u7f55\u89c1\u76ae\u80a4\u75c5\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u4e3a\u533b\u60a3\u5e26\u6765\u4e86\u5bf9\u6297\u75be\u75c5\u7684\u521b\u65b0\u2018\u5229\u5668\u2019\u3002\u201d<\/p>\n<p><b>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5927\u4e2d\u534e\u533a\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u8d1f\u8d23\u4eba\u8463\u535a\u6587<\/b>\u8868\u793a\uff1a\u201c\u7f55\u89c1\u76ae\u80a4\u75c5\u521b\u65b0\u836f\u5723\u5229\u5353<sup>&reg;<\/sup>\u662f\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u540c\u6b65\u7814\u53d1\u548c\u6ce8\u518c\u7684\u521b\u65b0\u4ea7\u54c1\uff0c\u5f97\u76ca\u4e8e\u4e2d\u56fd\u653f\u5e9c\u9f13\u52b1\u521b\u65b0\u548c\u65b0\u836f\u52a0\u901f\u5ba1\u8bc4\u5ba1\u6279\u653f\u7b56\u7684\u63a8\u8fdb\uff0c\u6211\u4eec\u975e\u5e38\u9a84\u50b2\u53ef\u4ee5\u5c06\u8fd9\u4e00\u521b\u65b0\u836f\u7269\u2018\u96f6\u65f6\u5dee\u2019\u5e26\u5230\u4e2d\u56fd\u3002\u611f\u8c22\u79ef\u6781\u53c2\u4e0e\u5723\u5229\u5353<sup>&reg;<\/sup>\u56fd\u9645\u4e34\u5e8a\u7814\u7a76\u7684\u4e2d\u56fd\u7814\u7a76\u8005\u53ca\u60a3\u8005\uff0c\u4e3a\u5168\u7403\u7814\u7a76\u8d21\u732e\u4e86\u2018\u4e2d\u56fd\u529b\u91cf\u2019\u3002\u672a\u6765\uff0c\u6211\u4eec\u8fd8\u5c06\u79ef\u6781\u4e0e\u4e1a\u754c\u5404\u65b9\u643a\u624b\uff0c\u63d0\u4f9b\u9664\u4e86\u521b\u65b0\u4ea7\u54c1\u4e4b\u5916\u7684\u66f4\u591a\u60a3\u8005\u670d\u52a1\uff0c\u5171\u540c\u63a8\u8fdbGPP\u60a3\u8005\u8bca\u7597\u751f\u6001\u7cfb\u7edf\u7684\u5efa\u8bbe\uff0c\u52a9\u529b\u60a3\u8005\u56de\u5f52\u5065\u5eb7\u548c\u9ad8\u8d28\u91cf\u7684\u751f\u6d3b\u3002\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\u53d1\u4f5c 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