{"id":87623,"date":"2022-12-12T10:26:00","date_gmt":"2022-12-12T03:26:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121210260087623"},"modified":"2022-12-12T22:20:21","modified_gmt":"2022-12-12T14:20:21","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e5%8f%a3%e5%a4%b4%e6%8a%a5%e5%91%8a%e8%80%90%e7%ab%8b%e5%85%8br%e6%b5%b7%e5%a4%96%e7%a0%94%e7%a9%b6%e5%9c%a82022-ash%e9%a6%96%e5%8f%91%e6%95%b0%e6%8d%ae%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121210260087623","title":{"rendered":"\u4e9a\u76db\u533b\u836f\u53e3\u5934\u62a5\u544a\u8010\u7acb\u514b(R)\u6d77\u5916\u7814\u7a76\u57282022 ASH\u9996\u53d1\u6570\u636e\uff0c\u5728ponatinib\u5931\u8d25\u60a3\u8005\u4e2d\u7684\u7597\u6548\u6570\u636e\u60ca\u8273"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02<\/span>2022\u5e7412\u670812\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u6628\u65e5\u5728\u7f8e\u56fd\u8def\u6613\u65af\u5b89\u90a3\u5dde\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c64\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology, ASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u516c\u5e03\u4e86\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b®<\/sup>\uff09\u6cbb\u7597\u96be\u6cbb\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u548c\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u7684\u521d\u6b65\u6570\u636e\uff0c\u6b64\u4e3a\u8010\u7acb\u514b®<\/sup>\u6d77\u5916\u4e34\u5e8a\u6570\u636e\u7684\u9996\u6b21\u5c55\u793a\u3002<\/p>\n

\n<\/p><\/div>\n

ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684\u201c\u4e2d\u56fd\u58f0\u97f3\u201d\uff0c\u4e9a\u76db\u533b\u836f\u5728\u4eca\u5e74\u7684ASH\u5e74\u4f1a\u4e0a\uff0c\u5c06\u901a\u8fc74\u9879\u53e3\u5934\u62a5\u544a\u516c\u5e035\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\uff0c\u6b64\u5916\uff0c\u516c\u53f8\u591a\u4e2a\u6838\u5fc3\u54c1\u79cd\u76f8\u5173\u8fdb\u5c55\u8fd8\u83b7\u90094\u9879ASH\u5e74\u4f1a\u58c1\u62a5\u5c55\u793a\uff0c\u5176\u4e2d3\u9879\u4e3a\u72ec\u7acb\u7814\u7a76\u8005\u57fa\u4e8e\u771f\u5b9e\u4e16\u754c\u7684\u7814\u7a76\u3002<\/p>\n

\u672c\u6b21\u4f1a\u8bae\u4e0a\u53e3\u5934\u62a5\u544a\u7684\u8010\u7acb\u514b®<\/sup>\u7f8e\u56fd\u4e34\u5e8a\u6570\u636e\u521d\u6b65\u663e\u793a\uff0c\u8be5\u54c1\u79cd\u5728\u96be\u6cbb\u6027CML\u548cPh+ ALL\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7279\u5f81\uff0c\u5e76\u6709\u6f5c\u529b\u6210\u4e3a\u5bf9\u7b2c\u4e09\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09ponatinib\u6216\u53d8\u6784STAMP\u6291\u5236\u5242asciminib\u8010\u836f\u60a3\u8005\u7684\u633d\u6551\u6027\u6cbb\u7597\u65b9\u6848\u3002\u6570\u636e\u663e\u793a\uff0c\u63a5\u8fd180%\u7684\u5165\u7ec4CML\u60a3\u8005\u6b64\u524d\u81f3\u5c11\u7ecf\u5386\u8fc7\u4e09\u7ebf\u6cbb\u7597\uff0c\u8d85\u8fc750%\u7684\u60a3\u8005\u5165\u7ec4\u524d\u7ecfponatinib\u6cbb\u7597\u5931\u8d25\uff1b\u5373\u4f7f\u662f\u8fd9\u6837\u63a5\u53d7\u8fc7\u91cd\u5ea6\u524d\u671f\u6cbb\u7597\u7684\u96be\u6cbbCML\u60a3\u8005\uff0c\u8010\u7acb\u514b®<\/sup>\u5728CML\u6162\u6027\u671f\uff08-CP\uff09\u60a3\u8005\u4e2d\u7684\u5b8c\u5168\u7ec6\u80de\u5b66\u53cd\u5e94\u7387\uff08CCyR\uff09\u548c\u4e3b\u8981\u5206\u5b50\u5b66\u53cd\u5e94\uff08MMR\uff09\u8fbe\u5230\u4e8677.8%\u548c43.5%\uff1b\u800c\u5728\u7ecfponatinib\u6cbb\u7597\u5931\u8d25\u7684CML-CP\u60a3\u8005\u4e2d\uff0cCCyR\u548cMMR\u9ad8\u8fbe83.3%\u548c42.9%\u3002<\/p>\n

\u6b64\u5916\uff0c\u8010\u7acb\u514b®<\/sup>\u7684\u8010\u53d7\u6027\u826f\u597d\u3002\u8be5\u7814\u7a76\u7684\u5b89\u5168\u6027\u6570\u636e\u4e0e\u5148\u524d\u53d1\u5e03\u7684\u4e2d\u56fd\u60a3\u8005\u6570\u636e\u7c7b\u4f3c\uff0c\u6ca1\u6709\u5728\u7f8e\u56fd\u60a3\u8005\u4e2d\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u98ce\u9669\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u54c1\u79cd\u5728ponatinib\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u4e2d\u5c55\u793a\u4e86\u5f88\u597d\u7684\u8010\u53d7\u6027\uff0c\u8fd9\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u5176\u5b89\u5168\u6027\u4f18\u52bf\u3002<\/p>\n

\u8010\u7acb\u514b®<\/sup>\u662f\u4e9a\u76db\u533b\u836f\u539f\u521b1\u7c7b\u65b0\u836f\uff0c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u4e14\u552f\u4e00\u83b7\u6279\u4e0a\u5e02\u7684\u4f34T315I\u7a81\u53d8\u8010\u836fCML\u6cbb\u7597\u6709\u6548\u836f\u7269\uff0c\u83b7\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u652f\u6301\uff0c\u5728\u5168\u7403\u5c42\u9762\u5177best-in-class\u6f5c\u529b\u3002\u8be5\u54c1\u79cd\u4e8e2021\u5e7411\u6708\u83b7\u6279\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u6253\u7834\u4e86\u4e2d\u56fd\u4f34T315I\u7a81\u53d8\u8010\u836fCML\u60a3\u8005\u957f\u671f\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5883\uff0c\u586b\u8865\u4e86\u56fd\u5185\u4e34\u5e8a\u6cbb\u7597\u3002<\/p>\n

MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09\u767d\u8840\u75c5\u79d1\u7684Elias Jabbour\u535a\u58eb\u8868\u793a\uff1a\u201c\u6b64\u6b21\u53d1\u5e03\u7684\u6570\u636e\u663e\u793a\uff0c\u8010\u7acb\u514b®<\/sup>\u6709\u6f5c\u529b\u6210\u4e3a\u65e2\u5f80\u6cbb\u7597\u5931\u8d25CML\u60a3\u8005\u7684\u633d\u6551\u6027\u6cbb\u7597\u65b9\u6848\u3002\u8010\u7acb\u514b®<\/sup>\u5728\u7814\u7a76\u4e2d\u6240\u663e\u793a\u7684\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u5341\u5206\u91cd\u8981\uff0c\u56e0\u4e3a\u5f88\u591aCML\u60a3\u8005\u5728\u63a5\u53d7\u5176\u5b83BCR-ABL1\u6291\u5236\u5242\u6cbb\u7597\u65f6\uff0c\u4f1a\u51fa\u73b0\u4e0d\u8010\u53d7\uff0c\u751a\u81f3\u6709\u53ef\u80fd\u53d1\u751f\u4e25\u91cd\u7684\u5fc3\u8840\u7ba1\u4e0d\u826f\u53cd\u5e94\u3002\u201c<\/p>\n

\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u201c\u4eca\u5e74\uff0c\u4e9a\u76db\u533b\u836f\u9996\u6b21\u516c\u5e03\u7684\u8010\u7acb\u514b®<\/sup>\u6d77\u5916\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u683c\u5916\u4ee4\u4eba\u60ca\u559c\uff01\u6570\u636e\u8868\u660e\u8be5\u54c1\u79cd\u6709\u671b\u514b\u670dponatinib\u548casciminib\u8010\u836f\uff0c\u8fd9\u5145\u5206\u4f53\u73b0\u4e86\u8010\u7acb\u514b®<\/sup>\u8fd9\u4e00\u5177\u6709best-in-class\u6f5c\u529b\u7684\u4e2d\u56fd\u539f\u521b\u836f\u7269\uff0c\u5728\u96be\u6cbb\u6027CML\u548cPh+ ALL\u6cbb\u7597\u9886\u57df\u62e5\u6709\u65e0\u9650\u6f5c\u529b\uff0c\u6709\u671b\u66f4\u8fdb\u4e00\u6b65\u89e3\u51b3\u5168\u7403CML\u548cPh+ ALL\u60a3\u8005\u7684\u4e34\u5e8a\u6025\u9700\u3002<\/p>\n

\u4eca\u5e74\uff0c\u6211\u4eec\u5728ASH\u5e74\u4f1a\u4e0a\u8fdb\u884c\u4e86\u8010\u7acb\u514b®<\/sup>\uff08\u5965\u96f7\u5df4\u66ff\u5c3c\uff09\u548cBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575 \u8fd92\u4e2a\u54c1\u79cd\u76844\u9879\u53e3\u5934\u62a5\u544a\u3002\u8fd9\u662f\u4e9a\u76db\u533b\u836f\u5168\u7403\u521b\u65b0\u80fd\u529b\u7684\u4f53\u73b0\uff0c\u6211\u611f\u5230\u975e\u5e38\u81ea\u8c6a\uff01\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301\u521d\u5fc3\uff0c\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u2019\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u201d<\/p>\n

\u8010\u7acb\u514b®<\/sup>\u57282022 ASH\u5e74\u4f1a\u4e0a\u53e3\u5934\u62a5\u544a\u7684\u7f8e\u56fd\u4e34\u5e8a\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08APG-2575\u4e0e\u8010\u7acb\u514b®<\/sup>\u4e2d\u56fd\u4e34\u5e8a\u7814\u7a76\u7684\u6458\u8981\u8be6\u7ec6\u4fe1\u606f\u53c2\u89c12022 ASH\u5e74\u4f1a\u671f\u95f4\u53d1\u5e03\u7684\u53e6\u5916\u4e24\u7bc7\u65b0\u95fb\u7a3f\uff09<\/p>\n

Olverembatinib (HQP1351) Overcomes Ponatinib Resistance in Patients with Heavily Pretreated\/Refractory Chronic Myeloid Leukemia (CML) and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL)<\/b><\/p>\n

\u5965\u96f7\u5df4\u66ff\u5c3c\uff08<\/b>HQP1351<\/b>\uff09\u53ef\u514b\u670d\u65e2\u5f80\u63a5\u53d7\u8fc7\u6df1\u5ea6\u6cbb\u7597<\/b>\/<\/b>\u96be\u6cbb\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08<\/b>CML<\/b>\uff09\u548c\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<\/b>Ph+ ALL<\/b>\uff09\u60a3\u8005\u5bf9\u4e8e<\/b>Ponatinib<\/b>\u7684\u8010\u836f<\/b><\/p>\n

    \n
  • \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a<\/li>\n
  • \u6458\u8981\u7f16\u53f7\uff1a#162387<\/li>\n
  • \u5206\u4f1a\u573a\uff1a632.\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff1a\u4e34\u5e8a\u53ca\u6d41\u884c\u75c5\u5b66\u8fdb\u5c55\uff1a\u65b0\u578b\u836f\u7269<\/li>\n
  • \u62a5\u544a\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f42022\u5e7412\u670810\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \/\u5317\u4eac\u65f6\u95f42022\u5e7412\u670810\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15<\/li>\n
  • \u6838\u5fc3\u8981\u70b9\uff1a<\/li>\n<\/ul>\n

    – \u5965\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u79cd\u65b0\u578b\u7684\u7b2c\u4e09\u4ee3BCR-ABL1 TKI\uff0c\u5bf9 CML \u548c Ph+ ALL \u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n

    – \u8fd9\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u3001\u968f\u673a\u5bf9\u7167\u7684\u4e34\u5e8a\u7814\u7a76\u9996\u6b21\u62a5\u544a\u4e86\u5965\u96f7\u5df4\u66ff\u5c3c\u5728\u4e2d\u56fd\u4ee5\u5916\u7684CML\u548cPh+ ALL\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u7279\u5f81\u3002\u8fd9\u4e9b\u60a3\u8005\u81f3\u5c11\u5bf92\u79cdBCR-ABL1\u6291\u5236\u5242\u8010\u836f\u6216\u4e0d\u8010\u53d7\uff0c\u5176\u4e2d\u5305\u62ecponatinib\u548casciminib\uff1b\u4f46\u643a\u5e26T315I\u7a81\u53d8\u7684\u60a3\u8005\u65e2\u5f80\u6cbb\u7597\u7ebf\u6570\u4e0d\u53d7\u9650\u5236\u3002\u60a3\u8005\u4ee53\uff1a3\uff1a2\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u5230\u5965\u96f7\u5df4\u66ff\u5c3c30\u300140\u621650mg \u7684\u8bd5\u9a8c\u7ec4\u4e2d\uff0c\u91c7\u7528\u9694\u65e5\u7ed9\u836f\uff08QOD\uff09\u7684\u65b9\u5f0f\uff0c28\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002<\/p>\n

    – \u622a\u81f32022\u5e7412\u67085\u65e5\uff0c\u5171\u670951\u4f8b\u60a3\u8005\u5165\u7ec4\uff0c\u5176\u4e2d\u5305\u62ecCML-CP\u60a3\u800538\u4f8b\uff0cCML-AP\u60a3\u8005\u3001CML\u6025\u53d8\u671f\uff08-BP\uff09\u60a3\u8005\u548cPh+ ALL \u60a3\u8005\u517113\u4f8b\u3002\u4ed6\u4eec\u7684\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u4e3a32.4\u5468\uff08\u8303\u56f40-119\u5468\uff09\u300254.9%\uff0828\/51\uff09\u60a3\u8005\u4e3a\u7537\u6027\uff0c\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u5e74\u9f84\u4e3a51\uff0821-79\uff09\u5c81\u3002\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0c\u5206\u522b\u67097\uff0813.7%\uff09\u300114\uff0827.5%\uff09\u548c25\uff0849%\uff09\u4f8b\u60a3\u8005\u66fe\u7ecf\u63a5\u53d7\u8fc72\u30013\u548c\u22654\u7ebf\u6cbb\u7597\uff1b\u5171\u670928\u4f8b\uff0854.9%\uff09\u7684\u60a3\u8005\u66fe\u7ecf\u63a5\u53d7\u8fc7\u7b2c\u4e09\u4ee3TKI ponatinib\u6cbb\u7597\uff0c\u5176\u4e2d\u8010\u836f21\u4f8b\uff0875.0%\uff09\uff0c\u4e0d\u8010\u53d77\u4f8b\uff0825.0%\uff09\uff1b\u5171\u670919\u4f8b\uff0837.3%\uff09\u60a3\u8005\u4f34\u6709T315I \u7a81\u53d8\uff1b\u5171\u670928\u4f8b\uff0854.9%\uff09\u60a3\u8005\u5728\u57fa\u7ebf\u65f6\u6709\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\uff0c\u5176\u4e2d\u9ad8\u8840\u538b\u60a3\u800518\u4f8b\uff0835.3%\uff09\u3002<\/p>\n

    – PK\u5206\u6790\u8868\u660e\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u7684\u8840\u6d46\u66b4\u9732\u91cf\u4ece30\u523050mg QOD\u5448\u5242\u91cf\u6bd4\u4f8b\u589e\u52a0\uff0c\u4e2d\u56fd\u548c\u7f8e\u56fdCML\u60a3\u8005\u7fa4\u4f53\u7684\u8840\u6d46\u66b4\u9732\u91cf\u76f8\u5f53\u3002<\/p>\n

    – \u5b89\u5168\u6027\uff1a\u5965\u96f7\u5df4\u66ff\u5c3c\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c34\u4f8b\u60a3\u8005\u7ecf\u5386\u4e86\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff08TRAE\uff09\uff0c\u5176\u53d1\u751f\u7387\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u5927\u591a\u6570\u975e\u8840\u6db2\u5b66TRAE\u4e3a 1\/2\u7ea7\uff1b\u5e38\u89c1\u76843\/4\u7ea7\u8840\u6db2\u5b66TRAE\u5305\u62ec\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0818.9%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0816.2%\uff09\u548c\u767d\u8840\u7403\u51cf\u5c11\u75c7\uff0813.5%\uff09\u3002\u5171\u57286\u4f8b\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e868\u9879\u4e0e\u5965\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08SAE\uff09\uff0c\u5747\u672a\u56e0\u6b64\u6c38\u4e45\u505c\u7528\u5965\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7597\u3002<\/p>\n

    – \u521d\u6b65\u7597\u6548\uff1a\u5965\u96f7\u5df4\u66ff\u5c3c\u5728CML\u548cPh+ ALL\u60a3\u8005\u4e2d\u5177\u6709\u5f3a\u6548\u7684\u6297\u767d\u8840\u75c5\u6d3b\u6027\u3002\u572823\u4f8b\u7597\u6548\u53ef\u8bc4\u4f30\u7684CML-CP\u60a3\u8005\u4e2d\uff0c14\/18\u4f8b\uff0877.8%\uff09\u83b7\u5f97CCyR\uff1b10\/23\uff0843.5%\uff09\u7684\u60a3\u8005\u83b7\u5f97MMR\u3002\u5965\u96f7\u5df4\u66ff\u5c3c\u5bf9T315I\u7a81\u53d8\u7684\u60a3\u8005\uff0887.5%\uff0cCCyR\uff1b55.6%, MMR\uff09\u548c\u4e0d\u4f34\u6709T315I\u7a81\u53d8\u7684\u60a3\u8005\uff0870.0%\uff0cCCyR\uff1b35.7%\uff0cMMR\uff09\u90fd\u6709\u6548\uff0c\u5176\u6709\u6548\u6027\u5e76\u672a\u56e0\u5148\u524d\u4f7f\u7528\u8fc7ponatinib\u6216asciminib\u800c\u53d7\u5230\u5f71\u54cd\u3002\u4f7f\u7528\u8fc7ponatinib\u7684\u60a3\u8005\u4e2d\u670910\/12\u4f8b\uff0883.3%\uff09\u83b7\u5f97CCyR\uff0c6\/14\u4f8b\uff0842.9%\uff09\u83b7\u5f97\u4e86MMR\u3002\u7279\u522b\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5373\u4f7f\u662f\u5bf9ponatinib\u8010\u836f\u7684\u60a3\u8005\uff0c\u4e5f\u67097\/9\u4f8b\uff0877.8%\uff09\u83b7\u5f97CCyR\uff0c5\/10\u4f8b\uff0850.0%\uff09\u83b7\u5f97MMR\u3002\u4f7f\u7528\u8fc7asciminib\u7684\u60a3\u8005\u4e2d\uff0c\u4e5f\u67091\u4f8b\u83b7\u5f97CCyR\u548cMMR\u3002\u57287\u4f8b\u53ef\u8bc4\u4f30\u7597\u6548\u7684\u8fdb\u5c55\u671fPh+\u767d\u8840\u75c5\u60a3\u8005\uff08\u5305\u62ecCML-AP, CML-BP\u4ee5\u53caPh+ALL\uff09\u4e2d\uff0c\u67092\u4f8b\u60a3\u8005\u8fbe\u5230CCyR\u548cMMR\uff0c\u8fd9\u4e24\u4f8b\u60a3\u8005\u5747\u4e3aponatinib\u8010\u836f\u60a3\u8005\uff0c\u4e14\u90fd\u4e0d\u4f34\u6709T315I\u7a81\u53d8\uff0c\u5176\u4e2d1\u4f8bPh+ ALL\u60a3\u8005\u4ec5\u7ecf\u8fc71\u4e2a\u5468\u671f\u5965\u96f7\u5df4\u66ff\u5c3c\u7684\u6cbb\u7597\uff0c\u5c31\u83b7\u5f97\u4e86CCyR\u3002<\/p>\n

    – \u7ed3\u8bba\uff1a\u5965\u96f7\u5df4\u66ff\u5c3c\u5728\u96be\u6cbb\u6027CML\u548cPh+ ALL\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u6709\u6548\u6027\u548c\u8010\u53d7\u6027\u3002\u5373\u4f7f\u5728ponatinib\u6216asciminib\u8010\u836f\u6216\u6709T315I \u7a81\u53d8\u7684\u60a3\u8005\u4e2d\uff0c\u5176\u4e5f\u663e\u793a\u51fa\u5f88\u5f3a\u7684\u7597\u6548\u3002\u8be5\u7814\u7a76\u8bc1\u5b9e\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u662fCML\u548cPh+ ALL\u60a3\u8005\u7684\u4e00\u79cd\u6f5c\u5728\u6cbb\u7597\u9009\u62e9\uff0c\u5305\u62ec\u90a3\u4e9bponatinib\u6cbb\u7597\u5931\u8d25\u6216T315I\u7a81\u53d8\u7684\u60a3\u8005\u3002<\/p>\n

    \u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/u><\/b><\/p>\n

    \u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n

    \u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67099\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5550\u591a\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7528\u4e8e\u6cbb\u7597\u8010\u836f\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\uff09\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9716\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c2\u9879FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u4ee5\u53ca2\u9879FDA\u513f\u7ae5\u7f55\u89c1\u75c5\u8d44\u683c\u8ba4\u8bc1\u3002\u516c\u53f8\u5148\u540e\u627f\u62c5\u591a\u9879\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff0c\u5176\u4e2d\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u98795\u9879\uff0c\u5305\u62ec1\u9879\u201c\u4f01\u4e1a\u521b\u65b0\u836f\u7269\u5b75\u5316\u57fa\u5730\u201d\u53ca4\u9879\u201c\u521b\u65b0\u836f\u7269\u7814\u53d1\u201d\uff0c\u53e6\u5916\u627f\u62c5\u201c\u91cd\u5927\u4f20\u67d3\u75c5\u9632\u6cbb\u201d\u4e13\u98791\u9879\u3002<\/p>\n

    \u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0eUNITY\u3001MD Anderson\u3001\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u4e1c\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u7b49\u9886\u5148\u7684\u751f\u7269\u6280\u672f\u53ca\u533b\u836f\u516c\u53f8\u3001\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u4e30\u5bcc\u7684\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u7ecf\u9a8c\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u540c\u65f6\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6807\u51c6\u6253\u9020\u540e\u671f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u53ca\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c\u201c\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u201d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

    \u524d\u77bb\u6027\u58f0\u660e<\/u><\/b><\/p>\n

    \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n

    <\/div>\n","protected":false},"excerpt":{"rendered":"

    \u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022022\u5e7412\u670812\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u6628\u65e5\u5728\u7f8e\u56fd\u8def\u6613\u65af\u5b89\u90a3\u5dde\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c64\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology, ASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u516c\u5e03\u4e86\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b®\uff09\u6cbb\u7597\u96be\u6cbb\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u548c\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u7684\u521d\u6b65\u6570\u636e\uff0c\u6b64\u4e3a\u8010\u7acb\u514b®\u6d77\u5916\u4e34\u5e8a\u6570\u636e\u7684\u9996\u6b21\u5c55\u793a\u3002 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ALL\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7279\u5f81\uff0c\u5e76\u6709\u6f5c\u529b\u6210\u4e3a\u5bf9\u7b2c\u4e09\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09ponatinib\u6216\u53d8\u6784STAMP\u6291\u5236\u5242asciminib\u8010\u836f\u60a3\u8005\u7684\u633d\u6551\u6027\u6cbb\u7597\u65b9\u6848\u3002\u6570\u636e\u663e\u793a\uff0c\u63a5\u8fd180%\u7684\u5165\u7ec4CML\u60a3\u8005\u6b64\u524d\u81f3\u5c11\u7ecf\u5386\u8fc7\u4e09\u7ebf\u6cbb\u7597\uff0c\u8d85\u8fc750%\u7684\u60a3\u8005\u5165\u7ec4\u524d\u7ecfponatinib\u6cbb\u7597\u5931\u8d25\uff1b\u5373\u4f7f\u662f\u8fd9\u6837\u63a5\u53d7\u8fc7\u91cd\u5ea6\u524d\u671f\u6cbb\u7597\u7684\u96be\u6cbbCML\u60a3\u8005\uff0c\u8010\u7acb\u514b®\u5728CML\u6162\u6027\u671f\uff08-CP\uff09\u60a3\u8005\u4e2d\u7684\u5b8c\u5168\u7ec6\u80de\u5b66\u53cd\u5e94\u7387\uff08CCyR\uff09\u548c\u4e3b\u8981\u5206\u5b50\u5b66\u53cd\u5e94\uff08MMR\uff09\u8fbe\u5230\u4e8677.8%\u548c43.5%\uff1b\u800c\u5728\u7ecfponatinib\u6cbb\u7597\u5931\u8d25\u7684CML-CP\u60a3\u8005\u4e2d\uff0cCCyR\u548cMMR\u9ad8\u8fbe83.3%\u548c42.9%\u3002 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\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u201c\u4eca\u5e74\uff0c\u4e9a\u76db\u533b\u836f\u9996\u6b21\u516c\u5e03\u7684\u8010\u7acb\u514b®\u6d77\u5916\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u683c\u5916\u4ee4\u4eba\u60ca\u559c\uff01\u6570\u636e\u8868\u660e\u8be5\u54c1\u79cd\u6709\u671b\u514b\u670dponatinib\u548casciminib\u8010\u836f\uff0c\u8fd9\u5145\u5206\u4f53\u73b0\u4e86\u8010\u7acb\u514b®\u8fd9\u4e00\u5177\u6709best-in-class\u6f5c\u529b\u7684\u4e2d\u56fd\u539f\u521b\u836f\u7269\uff0c\u5728\u96be\u6cbb\u6027CML\u548cPh+ ALL\u6cbb\u7597\u9886\u57df\u62e5\u6709\u65e0\u9650\u6f5c\u529b\uff0c\u6709\u671b\u66f4\u8fdb\u4e00\u6b65\u89e3\u51b3\u5168\u7403CML\u548cPh+ ALL\u60a3\u8005\u7684\u4e34\u5e8a\u6025\u9700\u3002 \u4eca\u5e74\uff0c\u6211\u4eec\u5728ASH\u5e74\u4f1a\u4e0a\u8fdb\u884c\u4e86\u8010\u7acb\u514b®\uff08\u5965\u96f7\u5df4\u66ff\u5c3c\uff09\u548cBcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575 \u8fd92\u4e2a\u54c1\u79cd\u76844\u9879\u53e3\u5934\u62a5\u544a\u3002\u8fd9\u662f\u4e9a\u76db\u533b\u836f\u5168\u7403\u521b\u65b0\u80fd\u529b\u7684\u4f53\u73b0\uff0c\u6211\u611f\u5230\u975e\u5e38\u81ea\u8c6a\uff01\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301\u521d\u5fc3\uff0c\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u2019\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u201d \u8010\u7acb\u514b®\u57282022 ASH\u5e74\u4f1a\u4e0a\u53e3\u5934\u62a5\u544a\u7684\u7f8e\u56fd\u4e34\u5e8a\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08APG-2575\u4e0e\u8010\u7acb\u514b®\u4e2d\u56fd\u4e34\u5e8a\u7814\u7a76\u7684\u6458\u8981\u8be6\u7ec6\u4fe1\u606f\u53c2\u89c12022 ASH\u5e74\u4f1a\u671f\u95f4\u53d1\u5e03\u7684\u53e6\u5916\u4e24\u7bc7\u65b0\u95fb\u7a3f\uff09 Olverembatinib (HQP1351) Overcomes Ponatinib Resistance in Patients with Heavily Pretreated\/Refractory Chronic Myeloid Leukemia (CML) and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) \u5965\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u53ef\u514b\u670d\u65e2\u5f80\u63a5\u53d7\u8fc7\u6df1\u5ea6\u6cbb\u7597\/\u96be\u6cbb\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u548c\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u5bf9\u4e8ePonatinib\u7684\u8010\u836f \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a \u6458\u8981\u7f16\u53f7\uff1a#162387 \u5206\u4f1a\u573a\uff1a632.\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff1a\u4e34\u5e8a\u53ca\u6d41\u884c\u75c5\u5b66\u8fdb\u5c55\uff1a\u65b0\u578b\u836f\u7269 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