{"id":87612,"date":"2022-12-12T11:57:00","date_gmt":"2022-12-12T04:57:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121211570087612"},"modified":"2022-12-12T22:13:58","modified_gmt":"2022-12-12T14:13:58","slug":"camizestrant%e4%b8%8e%e8%8a%99%e4%bb%95%e5%be%97%e7%9b%b8%e6%af%94%e6%98%be%e8%91%97%e5%bb%b6%e7%bc%93%e6%99%9a%e6%9c%9fer%e9%98%b3%e6%80%a7%e4%b9%b3%e8%85%ba%e7%99%8c%e6%82%a3%e8%80%85%e7%96%be","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022121211570087612","title":{"rendered":"Camizestrant\u4e0e\u8299\u4ed5\u5f97\u76f8\u6bd4\u663e\u8457\u5ef6\u7f13\u665a\u671fER\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\uff0c\u5ef6\u957f\u81f3\u5c113.5\u4e2a\u6708\u60a3\u8005\u83b7\u76ca"},"content":{"rendered":"

SABCS 2022\u4f1a\u8bae\u516c\u5e03\u7684SERENA-2 II\u671f\u8bd5\u9a8c\u7ed3\u679c\u663e\u793aCamizestrant\u4f5c\u4e3a\u65b0\u4e00\u4ee3\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53\u4e0b\u8c03\u5242\u5728\u5185\u5206\u6ccc\u6cbb\u7597\u4e2d\u7684\u6f5c\u529b<\/p>\n

\u4e0a\u6d77<\/span>2022\u5e7412\u670812\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — SERENA-2 II\u671f\u8bd5\u9a8c\u7684\u8be6\u7ec6\u7ed3\u679c\u663e\u793a\uff0c\u963f\u65af\u5229\u5eb7\u7684\u65b0\u4e00\u4ee3\u53e3\u670d\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53\u4e0b\u8c03\u5242(ngSERD) Camizestrant 75mg\u548c150mg\u4e24\u79cd\u5242\u91cf\uff0c\u4e0e\u8299\u4ed5\u5f97\uff08\u901a\u7528\u540d\uff1a\u6c1f\u7ef4\u53f8\u7fa4\uff09500mg\u5242\u91cf\u76f8\u6bd4\uff0c\u5728\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u5185\u5206\u6ccc\u6cbb\u7597\u7684\u7edd\u7ecf\u540e\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u65f6\uff0c\u5728\u6539\u5584\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09\u65b9\u9762\u5747\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u3002\u76f8\u5173\u7ed3\u679c\u57282022\u5e74\u5723\u5b89\u4e1c\u5c3c\u5965\u4e73\u817a\u764c\u7814\u8ba8\u4f1a\uff08SABCS\uff09\u4e0a\u4ee5\u53e3\u5934\u62a5\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u3002<\/p>\n

\u5728\u603b\u4eba\u7fa4\u4e2d\uff0c\u4e0e\u76ee\u524dSERD\u7684\u6807\u51c6\u6cbb\u7597\u6c1f\u7ef4\u53f8\u7fa4\u76f8\u6bd4\uff0cCamizestrant 75mg\u5242\u91cf\u53ef\u663e\u8457\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u966942%\uff08\u57fa\u4e8e\u98ce\u9669\u6bd4[HR]0.58\uff0c90%\u7f6e\u4fe1\u533a\u95f4[CI]0.41-0. 81\uff1bp=0.0124\uff1b\u4e2d\u4f4dPFS\u4e3a7.2\u4e2a\u6708\uff1a3.7\u4e2a\u6708\uff09\uff0cCamizestrant 150mg\u5242\u91cf\u53ef\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u966933%\uff08HR 0.67\uff0c90% CI 0.48-0.92\uff1bp=0.0161\uff1b\u4e2d\u4f4dPFS\u4e3a7.7\uff1a3.7\u4e2a\u6708\uff09\u3002<\/p>\n

\u5728\u9884\u5148\u6307\u5b9a\u7684ESR1\u7a81\u53d8\u60a3\u8005\u4e9a\u7ec4\u4e2d\uff08\u5360\u8bd5\u9a8c\u4eba\u7fa4\u768436.7%\uff09\uff0c\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u76f8\u6bd4\uff0cCamizestrant 75mg\u5242\u91cf\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u966967%\uff08HR 0.33\uff0c90% CI 0.18-0.58\uff1b\u4e2d\u4f4dPFS\u4e3a6.3\u4e2a\u6708\uff1a2.2\u4e2a\u6708\uff09\uff0c150mg\u5242\u91cf\u964d\u4f4e45%\uff08HR 0.55\uff0c90% CI 0.33-0.89\uff1b\u4e2d\u4f4dPFS\u4e3a9.2\uff1a2.2\u4e2a\u6708\uff09\u3002Camizestrant\u5728\u6ca1\u6709\u68c0\u6d4b\u5230ESR1\u7a81\u53d8\u7684\u60a3\u8005\u4e2d\u4e5f\u6709\u7597\u6548\uff0c75mg\u548c150mg\u5242\u91cf\u6c34\u5e73\u4e0b\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u5206\u522b\u964d\u4f4e22%\u548c24%\uff08HR 0.78\uff0c90%CI 0.50-1.22\u548cHR 0.76\uff0c90%CI 0.48-1.20\uff09\u3002 <\/p>\n

\u5728\u5176\u4ed6\u9884\u5148\u6307\u5b9a\u7684\u4e9a\u7ec4\u4e2d\u4e5f\u89c2\u5bdf\u5230\u6709\u4e34\u5e8a\u610f\u4e49\u7684PFS\u83b7\u76ca\uff0c\u5305\u62ec\u5148\u524d\u63a5\u53d7\u8fc7\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08CDK\uff094\/6\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u3001\u6709\u80ba\u8f6c\u79fb\u548c\/\u6216\u809d\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u6709ER\u9a71\u52a8\u75be\u75c5\u7684\u60a3\u8005\u3002<\/p>\n

\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3Vall d’Hebron\u80bf\u7624\u7814\u7a76\u6240\u548cSERENA-2 II\u671f\u8bd5\u9a8c\u7684\u9996\u5e2d\u7814\u7a76\u5458Mafalda Oliveira\u535a\u58eb\u8868\u793a\uff1a\u201c\u8fd9\u4e9b\u6570\u636e\u53cd\u6620\u51fa\u6211\u4eec\u4e3a\u665a\u671fER\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6f5c\u5728\u6cbb\u7597\u9009\u62e9\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65\u3002\u6839\u636eSERENA-2\u8bd5\u9a8c\u7ed3\u679c\uff0cCamizestrant\u7684\u4e24\u79cd\u5242\u91cf\u90fd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u80fd\u660e\u663e\u6539\u5584\u60a3\u8005\u9884\u540e\uff0c\u4e0e\u76ee\u524d\u7684SERD\u6807\u51c6\u6cbb\u7597\u76f8\u6bd4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u51e0\u4e4e\u7ffb\u4e86\u4e00\u756a\u3002\u201d<\/p>\n

\u963f\u65af\u5229\u5eb7\u9996\u5e2d\u533b\u5b66\u5b98\uff0c\u80bf\u7624\u7814\u53d1\u9996\u5e2d\u5f00\u53d1\u5b98Cristian Massacesi\u8868\u793a\uff1a\u201cCamizestrant\u5728SERENA-2\u8bd5\u9a8c\u4e2d\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u76f8\u6bd4\u8868\u73b0\u51fa\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\uff0c\u8fd9\u8868\u660e\u6211\u4eec\u7684\u65b0\u4e00\u4ee3SERD\u6709\u6f5c\u529b\u4f18\u5316\u665a\u671fER\u9a71\u52a8\u578b\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\uff0c\u65e0\u8bba\u8fd9\u4e9b\u60a3\u8005\u7684ESR1\u7a81\u53d8\u60c5\u51b5\uff0c\u4ee5\u53ca\u4e4b\u524d\u662f\u5426\u4f7f\u7528\u8fc7CDK4\/6\u6291\u5236\u5242\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u4e3a\u5168\u9636\u6bb5\u4e73\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u836f\u7269\uff0c\u671f\u5f85\u6b63\u5728\u8fdb\u884c\u7684Camizestrant III\u671f\u8bd5\u9a8c\uff08\u5305\u62ecSERENA-4\u548cSERENA-6\uff09\u6709\u66f4\u591a\u53d1\u73b0\u3002\u201d<\/p>\n

\u8bd5\u9a8c\u7ed3\u679c\u6458\u8981\uff1a<\/b>SERENA-2<\/b><\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u6709\u6548\u6027\u6307\u6807<\/span><\/p>\n<\/td>\n

\n

Camizestrant (75mg)<\/b><\/span><\/p>\n<\/td>\n

\n

Camizestrant (150mg)<\/b><\/span><\/p>\n<\/td>\n

\n

\u6c1f\u7ef4\u53f8\u7fa4\uff08<\/i><\/b>500mg<\/i><\/b>\uff09<\/i><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u9996\u8981\u7ec8\u70b9<\/i><\/span><\/p>\n<\/td>\n

<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

\u603b\u4eba\u7fa4\uff08<\/span>n<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

74<\/span><\/p>\n<\/td>\n

\n

73<\/span><\/p>\n<\/td>\n

\n

73<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d<\/span>PFS<\/span>\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n

\n

7.2<\/span><\/p>\n<\/td>\n

\n

7.7<\/span><\/p>\n<\/td>\n

\n

3.7<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8c03\u6574<\/span>HR<\/span>\uff08<\/span>90% CI<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

0.58 (0.41-0.81)<\/span><\/p>\n<\/td>\n

\n

0.67 (0.48-0.92)<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

P<\/span>\u503c<\/span><\/p>\n<\/td>\n

\n

0.0124*<\/span><\/p>\n<\/td>\n

\n

0.0161*<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u9884\u5148\u8bbe\u5b9a\u4e9a\u7ec4\u4eba\u7fa4<\/i><\/b><\/span><\/p>\n<\/td>\n

<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\n

\u68c0\u6d4b\u5230\u7684<\/span>ESR1m<\/span>\u4eba\u7fa4<\/span> (n)<\/span><\/p>\n<\/td>\n

\n

22<\/span><\/p>\n<\/td>\n

\n

26<\/span><\/p>\n<\/td>\n

\n

35<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d<\/span>PFS<\/span>\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n

\n

6.3<\/span><\/p>\n<\/td>\n

\n

9.2<\/span><\/p>\n<\/td>\n

\n

2.2<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8c03\u6574<\/span>HR<\/span>\uff08<\/span>90% CI<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

0.33 (0.18-0.58)<\/span><\/p>\n<\/td>\n

\n

0.55 (0.33-0.89)<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u672a\u68c0\u6d4b\u5230\u7684<\/span>ESR1m<\/span>\u4eba\u7fa4<\/span> (n)<\/span><\/p>\n<\/td>\n

\n

51<\/span><\/p>\n<\/td>\n

\n

46<\/span><\/p>\n<\/td>\n

\n

37<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d<\/span>PFS<\/span>\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n

\n

7.2<\/span><\/p>\n<\/td>\n

\n

5.8<\/span><\/p>\n<\/td>\n

\n

7.2<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8c03\u6574<\/span>HR<\/span>\uff08<\/span>90% CI<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

0.78 (0.50-1.22)<\/span><\/p>\n<\/td>\n

\n

0.76 (0.48-1.20)<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e4b\u524d\u63a5\u53d7\u8fc7<\/span>CDK4\/6<\/span>\u6291\u5236\u5242\u6cbb\u7597\u4eba\u7fa4\uff08<\/span>n<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

38<\/span><\/p>\n<\/td>\n

\n

37<\/span><\/p>\n<\/td>\n

\n

37<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d<\/span>PFS<\/span>\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n

\n

5.5<\/span><\/p>\n<\/td>\n

\n

3.8<\/span><\/p>\n<\/td>\n

\n

2.1<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8c03\u6574<\/span>HR<\/span>\uff08<\/span>90% CI<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

0.49 (0.31-0.75)<\/span><\/p>\n<\/td>\n

\n

0.68 (0.44-1.04)<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5b58\u5728\u80ba\u90e8\u548c<\/span>\/<\/span>\u6216\u809d\u810f\u8f6c\u79fb\u4eba\u7fa4\uff08<\/span>n<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

43<\/span><\/p>\n<\/td>\n

\n

43<\/span><\/p>\n<\/td>\n

\n

43<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d<\/span>PFS<\/span>\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n

\n

7.2<\/span><\/p>\n<\/td>\n

\n

5.6<\/span><\/p>\n<\/td>\n

\n

2.0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8c03\u6574<\/span>HR<\/span>\uff08<\/span>90% CI<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

0.43 (0.28-0.65)<\/span><\/p>\n<\/td>\n

\n

0.55 (0.37-0.82)<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6709<\/span>ER<\/span>\u9a71\u52a8\u75be\u75c5\u8bc1\u636e\u4eba\u7fa4\uff08<\/span>n\uff09<\/span><\/p>\n<\/td>\n

\n

50<\/span><\/p>\n<\/td>\n

\n

53<\/span><\/p>\n<\/td>\n

\n

53<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e2d\u4f4d<\/span>PFS<\/span>\uff08\u6708\uff09<\/span><\/p>\n<\/td>\n

\n

7.4<\/span><\/p>\n<\/td>\n

\n

12.0<\/span><\/p>\n<\/td>\n

\n

3.2<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8c03\u6574<\/span>HR<\/span>\uff08<\/span>90% CI<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

0.53 (0.35-0.79)<\/span><\/p>\n<\/td>\n

\n

0.58 (0.39-0.86)<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

*\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff1bHR\uff0c\u98ce\u9669\u6bd4\uff08\u6839\u636e\u5206\u5c42\u56e0\u7d20[\u5148\u524d\u4f7f\u7528CDK4\/6i\u548c\u5b58\u5728\u80ba\u548c\/\u6216\u809d\u8f6c\u79fb] \u8c03\u6574\uff09\uff1bCI\uff0c\u7f6e\u4fe1\u533a\u95f4\uff1bPFS\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\uff1bESR1m\uff0cESR1\u7a81\u53d8\u3002<\/p>\n

Camizestrant\u7684\u8010\u53d7\u6027\u666e\u904d\u826f\u597d\uff0c\u5176\u5b89\u5168\u6027\u4e0e\u4ee5\u524d\u7684\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u4e00\u81f4\uff0c\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u540e\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u5728Camizestrant 75mg\u3001150mg\u548c300mg\u7ec4\uff0c\u4ee5\u53ca\u6c1f\u7ef4\u53f8\u7fa4\u7ec4\u5149\u76f2\u75c7\uff08\u5206\u522b\u4e3a12.2%\u300124.7%\u300135.0%\u548c0%\uff09\u548c\u5fc3\u52a8\u8fc7\u7f13\uff08\u5206\u522b\u4e3a5.4%\u300126.0%\u300140.0%\u548c0%\uff09\uff0c\u5747\u4e3a1\u62162\u7ea7\u3002\u5728Camizestrant 75mg\u3001150mg\u548c300mg\u7ec4\uff0c\u4ee5\u53ca\u6c1f\u7ef4\u53f8\u7fa4\u7ec4\u5206\u522b\u67091.4%\u30012.7%\u30015.0%\u548c1.4%\u7684\u60a3\u8005\u51fa\u73b03\u7ea7\u6216\u4ee5\u4e0a\u7684TEAEs\uff0c\u5176\u4e2d\u56e0\u6b64\u4e2d\u65ad\u6cbb\u7597\u7684\u53ea\u5728Camizestrant 75mg\u7ec4\u67092\u540d\uff0cCamizestrant 150mg\u548c300mg\u7ec4\uff0c\u4ee5\u53ca\u6c1f\u7ef4\u53f8\u7fa4\u7ec4\u6ca1\u6709\u3002  <\/p>\n

\u963f\u65af\u5229\u5eb7\u4e3a\u8bc4\u4f30Camizestrant\u6cbb\u7597\u665a\u671f\u4e73\u817a\u764c\u5236\u5b9a\u4e86\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u3002SERENA-6 III\u671f\u8bd5\u9a8c\u9488\u5bf9\u4f7f\u7528\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u53ef\u68c0\u6d4b\u7684ESR1\u7a81\u53d8\u7684HR\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u8bc4\u4f30Camizestrant\u4e0eCDK4\/6\u6291\u5236\u5242\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u7684\u60c5\u51b5\uff0cSERENA-4 III\u671f\u8bd5\u9a8c\u8bc4\u4f30Camizestrant\u8054\u5408palbociclib\uff08CDK4\/6\u6291\u5236\u5242\uff09\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597HR\u9633\u6027\u3001\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u60c5\u51b5\u3002SERENA-6\u8bd5\u9a8c\u8003\u5bdf\u7684\u9002\u5e94\u75c7\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u5feb\u901f\u901a\u9053\u6307\u5b9a\u3002<\/p>\n

 <\/p>\n

\u5173\u4e8e\u6fc0\u7d20\u53d7\u4f53\uff08<\/b>HR<\/b>\uff09\u9633\u6027\u4e73\u817a\u764c<\/b><\/p>\n

\u4e73\u817a\u764c\u662f\u6700\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u4e5f\u662f\u5168\u4e16\u754c\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00[1]<\/sup>\u30022020\u5e74\u6709\u8d85\u8fc7200\u4e07\u4eba\u88ab\u8bca\u65ad\u4e3a\u4e73\u817a\u764c\uff0c\u5168\u7403\u6709\u8fd168.5\u4e07\u4eba\u56e0\u6b64\u6b7b\u4ea1[1]<\/sup>\u3002<\/p>\n

HR\u9633\u6027\u4e73\u817a\u764c\uff08\u8868\u8fbe\u96cc\u6fc0\u7d20\u6216\u5b55\u6fc0\u7d20\u53d7\u4f53\uff0c\u6216\u4e24\u8005\u517c\u6709\uff09\uff0c\u662f\u6700\u5e38\u89c1\u7684\u4e73\u817a\u764c\u4e9a\u578b\uff0c\u5927\u7ea670%\u7684\u4e73\u817a\u764c\u88ab\u8ba4\u4e3a\u662fHR\u9633\u6027\uff0cHER2\u4f4e\u8868\u8fbe\u6216\u9634\u6027[2]<\/sup>\u3002<\/p>\n

HR\u9633\u6027\u4e73\u817a\u764c\u7ec6\u80de\u7684\u751f\u957f\u901a\u5e38\u7531\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\u9a71\u52a8[<\/sup>3]<\/sup>\uff0c\u9488\u5bf9ER\u9a71\u52a8\u75be\u75c5\u7684\u5185\u5206\u6ccc\u7597\u6cd5\u88ab\u5e7f\u6cdb\u7528\u4f5c\u665a\u671f\u4e73\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u901a\u5e38\u4e0e\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08CDK\uff094\/6\u6291\u5236\u5242\u8054\u5408[<\/sup>4<\/sup>\uff0c<\/sup>5]<\/sup>\u3002\u7136\u800c\uff0c\u8bb8\u591a\u665a\u671f\u75be\u75c5\u60a3\u8005\u5bf9CDK4\/6\u6291\u5236\u5242\u548c\u76ee\u524d\u5185\u5206\u6ccc\u7597\u6cd5\u4ea7\u751f\u8010\u836f\u6027[<\/sup>5]<\/sup>\u3002 \u4e00\u65e6\u53d1\u751f\u8fd9\u79cd\u60c5\u51b5\uff0c\u6cbb\u7597\u9009\u62e9\u5c31\u5f88\u6709\u9650[<\/sup>5]<\/sup>\uff0c\u5316\u7597\u662f\u76ee\u524d\u6807\u51c6\u7597\u6cd5[<\/sup>6]<\/sup>\uff0c\u4f46\u751f\u5b58\u7387\u5f88\u4f4e\uff0c\u9884\u4f30\u4ec530%\u7684\u60a3\u8005\u5728\u8bca\u65ad\u540e\u80fd\u5b58\u6d3b\u8d85\u8fc7\u4e94\u5e74[<\/sup>2]<\/sup>\u3002<\/p>\n

\u4f18\u5316\u5185\u5206\u6ccc\u6cbb\u7597\uff0c\u514b\u670dER\u9a71\u52a8\u75be\u75c5\u60a3\u8005\u5728\u6240\u6709\u6cbb\u7597\u9636\u6bb5\u7684\u8010\u836f\u6027\uff0c\u4ee5\u53ca\u4e3a\u4e0d\u518d\u6709ER\u9a71\u52a8\u75be\u75c5\u7684\u60a3\u8005\u786e\u5b9a\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u662f\u4e73\u817a\u764c\u7814\u7a76\u7684\u79ef\u6781\u91cd\u70b9\u9886\u57df\u3002<\/p>\n

\u5173\u4e8e<\/b>SERENA-2<\/b>\u8bd5\u9a8c<\/b><\/p>\n

SERENA-2\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5e73\u884c\u7ec4\u3001\u591a\u4e2d\u5fc3 II \u671f\u8bd5\u9a8c\uff0c\u8bc4\u4f30Camizestrant\u7684\u51e0\u4e2a\u5242\u91cf\u6c34\u5e73\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u76f8\u6bd4\u5728\u665a\u671fER\u9633\u6027\u3001HER2\u9634\u6027\u4e73\u817a\u764c\u4e2d\u7684\u6548\u679c\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u8bc4\u4f30Camizestrant\uff0875mg\uff09\u4e0e \u6c1f\u7ef4\u53f8\u7fa4\uff08500mg\uff09\u3001 Camizestrant\uff08150mg\uff09\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09\uff0c\u5176\u4e2dPFS\u7684\u5b9a\u4e49\u4e3a\u5b9e\u4f53\u7624 (RECIST) \u7248\u672c 1.1\u53cd\u5e94\u8bc4\u4f30\u6807\u51c6\u5b9a\u4e49\u7684 PFS\u3002240\u540d\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7Camizestrant\u6216\u6c1f\u7ef4\u53f8\u7fa4\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec24\u5468\u7684\u5b89\u5168\u6027\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u4e34\u5e8a\u53d7\u76ca\u7387 (CBR)\u3002<\/p>\n

\u5173\u4e8e<\/b>Camizestrant<\/b><\/p>\n

Camizestrant\u662f\u4e00\u79cd\u6709\u6548\u7684\u65b0\u4e00\u4ee3\u53e3\u670dSERD\u548c\u5b8c\u5168ER\u03b1\u62ee\u6297\u5242\uff0c\u5df2\u5728\u4e00\u7cfb\u5217\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u6297\u764c\u6d3b\u6027\uff0c\u5305\u62ec\u90a3\u4e9b\u5177\u6709ER\u6fc0\u6d3b\u7a81\u53d8\u7684\u6a21\u578b\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u5f00\u5c55\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\uff0c\u8bc4\u4f30Camizestrant\u4f5c\u4e3a\u5355\u836f\u6216\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u5408\u4f7f\u7528\u65f6\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4ee5\u5e94\u5bf9HR\u9633\u6027\u4e73\u817a\u764c\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002<\/p>\n

\u9664\u4e86SERENA-2\u8bd5\u9a8c\u548c\u6b63\u5728\u8fdb\u884c\u7684SERENA-4\u548cSERENA-6\u8bd5\u9a8c\u5916\uff0cSERENA-1I\u671f\u8bd5\u9a8c\u8868\u660e\uff0c\u5f53\u5355\u72ec\u4f7f\u7528\u6216\u4e0eCDK4\/6\u6291\u5236\u5242\u54cc\u67cf\u897f\u5229\u8054\u5408\u4f7f\u7528\u65f6\uff0cCamizestrant\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002SERENA-1\u8bd5\u9a8c\u4e2d\u6b63\u5728\u63a2\u7d22\u4e0e\u5176\u4ed6\u7ec4\u5408\u7684\u7814\u7a76\u3002<\/p>\n

\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u4e73\u817a\u764c\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n

\u968f\u7740\u5bf9\u4e73\u817a\u764c\u751f\u7269\u5b66\u7684\u65e5\u76ca\u4e86\u89e3\uff0c\u963f\u65af\u5229\u5eb7\u5f00\u59cb\u6311\u6218\u548c\u91cd\u65b0\u5b9a\u4e49\u4e73\u817a\u764c\u7684\u5206\u7c7b\u53ca\u4e34\u5e8a\u6cbb\u7597\u6a21\u5f0f\uff0c\u4ee5\u63d0\u4f9b\u7ed9\u60a3\u8005\u6240\u9700\u7684\u66f4\u4e3a\u7cbe\u51c6\u800c\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002\u963f\u65af\u5229\u5eb7\u96c4\u5fc3\u52c3\u52c3\uff0c\u5e0c\u671b\u6709\u671d\u4e00\u65e5\u53ef\u4ee5\u6d88\u9664\u4e73\u817a\u764c\u8fd9\u4e00\u81f4\u6b7b\u75c5\u56e0\u3002<\/p>\n

\u963f\u65af\u5229\u5eb7\u7814\u53d1\u4e86\u4e00\u7cfb\u5217\u5df2\u83b7\u6279\u6216\u6709\u671b\u83b7\u6279\u7684\u836f\u7269\uff0c\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5e94\u5bf9\u4e73\u817a\u764c\u80bf\u7624\u5fae\u73af\u5883\u7684\u751f\u7269\u591a\u6837\u6027\u3002<\/p>\n

\u51ed\u501f\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff08trastuzumab deruxtecan\uff09\uff0c\u4e00\u79cd\u9776\u5411HER2\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff0c\u963f\u65af\u5229\u5eb7\u548c\u7b2c\u4e00\u4e09\u5171\u7684\u76ee\u6807\u662f\u6539\u5584\u5148\u524d\u6cbb\u7597\u7684HER2\u9633\u6027\u548cHER2\u4f4e\u8868\u8fbe\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u7ed3\u679c\uff0c\u5e76\u6b63\u5728\u63a2\u7d22\u5176\u5728\u66f4\u65e9\u7ebf\u7684\u6cbb\u7597\u548c\u65b0\u578b\u4e73\u817a\u764c\u4e2d\u7684\u6f5c\u529b\u3002<\/p>\n

\u5728HR\u9633\u6027\u4e73\u817a\u764c\u4e2d\uff0c\u963f\u65af\u5229\u5eb7\u7ee7\u7eed\u6301\u7eed\u57fa\u77f3\u836f\u7269\u6c1f\u7ef4\u53f8\u7fa4\u548c\u6208\u820d\u745e\u6797\u6539\u5584\u9884\u540e\uff0c\u5e76\u65e8\u5728\u901a\u8fc7ngSERD Camizestrant\u548c\u6f5c\u5728\u65b0\u836fAKT\u6fc0\u9176\u6291\u5236\u5242Capivasertib\u91cd\u5851HR\u9633\u6027\u4e73\u817a\u764c\u6cbb\u7597\u3002\u540c\u65f6\uff0c\u963f\u65af\u5229\u5eb7\u4e0e\u7b2c\u4e00\u4e09\u5171\u5408\u4f5c\uff0c\u63a2\u7d22 TROP2\u9776\u5411ADC datopotamab deruxtecan\u7684\u6f5c\u5728\u6548\u679c\u3002<\/p>\n

PARP\u6291\u5236\u5242\u5965\u62c9\u5e15\u5229\u662f\u4e00\u79cd\u9776\u5411\u6cbb\u7597\u9009\u62e9\uff0c\u5df2\u5728\u9057\u4f20\u6027BRCA\u7a81\u53d8\u7684HER2\u9634\u6027\u65e9\u671f\u548c\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u963f\u65af\u5229\u5eb7\u548c\u9ed8\u6c99\u4e1c\u6301\u7eed\u63a2\u7d22\u5965\u62c9\u5e15\u5229\u5728BRCA\u9057\u4f20\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u6548\u679c\uff0c\u540c\u65f6\u6b63\u5bfb\u6c42\u65b0\u7684\u5951\u673a\u4f7f\u8fd9\u7c7b\u60a3\u8005\u5728\u75be\u75c5\u66f4\u65e9\u671f\u63a5\u53d7\u6cbb\u7597\u3002<\/p>\n

\u4e3a\u4e86\u6ee1\u8db3\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u5bf9\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u7684\u8feb\u5207\u9700\u6c42\uff0c\u963f\u65af\u5229\u5eb7\u6b63\u5728\u8bc4\u4f30datopotamab deruxtecan\u5355\u72ec\u4f7f\u7528\u548c\u4e0e\u514d\u75ab\u7597\u6cd5durvalumab\u8054\u5408\u4f7f\u7528\u7684\u6f5c\u529b\uff0c\u8bc4\u4f30capivasertib\u4e0e\u5316\u7597\u8054\u5408\u4f7f\u7528\uff0c\u4ee5\u53cadurvalumab\u4e0e\u5176\u4ed6\u80bf\u7624\u836f\u7269\uff0c\u5305\u62ec\u5965\u62c9\u5e15\u5229\u548c\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u4f7f\u7528\u7684\u6548\u679c\u3002<\/p>\n

\u5173\u4e8e\u963f\u65af\u5229\u5eb7\u5728\u80bf\u7624\u9886\u57df\u7684\u7814\u7a76<\/b><\/p>\n

\u963f\u65af\u5229\u5eb7\u6b63\u5f15\u9886\u7740\u80bf\u7624\u9886\u57df\u7684\u4e00\u573a\u9769\u547d\uff0c\u81f4\u529b\u63d0\u4f9b\u591a\u5143\u5316\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u79d1\u5b66\u63a2\u7d22\u80bf\u7624\u9886\u57df\u7684\u590d\u6742\u6027\uff0c\u53d1\u73b0\u3001\u7814\u53d1\u5e76\u5411\u60a3\u8005\u63d0\u4f9b\u6539\u53d8\u751f\u547d\u7684\u836f\u7269\u3002<\/p>\n

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\u5173\u4e8e\u963f\u65af\u5229\u5eb7<\/b><\/p>\n

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\u58f0\u660e<\/b><\/p>\n

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1. Sung H, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin.<\/i> 2021; 10.3322\/caac.21660.<\/span><\/p>\n<\/td>\n<\/tr>\n

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2. National Cancer Institute. Surveillance, Epidemiology and End Results Cancer Stat Facts: Female Breast Cancer Subtypes. Available at:\u202fhttps:\/\/seer.cancer.gov\/statfacts\/html\/breast-subtypes.html<\/a>. Accessed December 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n

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3. Scabia V, et al. Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor. Nat Commun.<\/i> 2022; 10.1038\/s41467-022-30898-0.<\/span><\/p>\n<\/td>\n<\/tr>\n

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4. Lin M, et al. Comparative Overall Survival of CDK4\/6 Inhibitors Plus Endocrine Therapy vs. Endocrine Therapy Alone for Hormone receptor-positive, HER2-negative metastatic breast cancer. J Cancer.<\/i> 2020; 10.7150\/jca.48944.<\/span><\/p>\n<\/td>\n<\/tr>\n

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5. Lloyd M R, et al. Mechanisms of Resistance to CDK4\/6 Blockade in Advanced Hormone Receptor-positive, HER2-negative Breast Cancer and Emerging Therapeutic Opportunities. Clin Cancer Res.<\/i> 2022; 28(5):821-30.<\/span><\/p>\n<\/td>\n<\/tr>\n

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6. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology (NCCN Guidelines). Available at: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1419.<\/a> Accessed December 2022.  <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

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