{"id":87299,"date":"2022-12-06T17:20:00","date_gmt":"2022-12-06T10:20:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022120617200087299"},"modified":"2022-12-06T22:25:04","modified_gmt":"2022-12-06T14:25:04","slug":"imjudo%e8%81%94%e5%90%88%e8%8b%b1%e9%a3%9e%e5%87%a1%e4%b8%80%e7%ba%bf%e6%b2%bb%e7%96%97%e4%b8%8d%e5%8f%af%e5%88%87%e9%99%a4%e7%9a%84%e8%82%9d%e7%99%8c%e5%9c%a8%e4%b8%ad%e5%9b%bd%e6%b8%af%e5%8f%b0","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022120617200087299","title":{"rendered":"Imjudo\u8054\u5408\u82f1\u98de\u51e1\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u764c\u5728\u4e2d\u56fd\u6e2f\u53f0\u4eba\u7fa4\u4e2d\u8bc1\u5b9e\u4e86\u663e\u8457\u7684\u751f\u5b58\u83b7\u76ca"},"content":{"rendered":"

\u2162\u671f\u4e34\u5e8a\u7814\u7a76HIMALAYA\u7684\u4e9a\u6d32\u4e9a\u7ec4\u4e2d\u56fd\u6e2f\u53f0\u6570\u636e\u663e\u793a\uff0c\u5355\u6b21\u542f\u52a8\u5242\u91cf\u7684Imjudo\u8054\u5408\u82f1\u98de\u51e1\u53ef\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e56%<\/p>\n

\u4e0a\u6d77<\/span>2022\u5e7412\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 2022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u4e9a\u6d32\u5927\u4f1a\/\u5e74\u4f1a\uff08ESMO ASIA<\/span> 2022\uff09\u4e8e12\u67082\u65e5\u6b63\u5f0f\u516c\u5e03\u4e86\u5728\u2162\u671f\u4e34\u5e8a\u7814\u7a76HIMALAYA\u4e2d\uff0c\u963f\u65af\u5229\u5eb7\u516c\u53f8\u7684Imjudo\uff08\u901a\u7528\u540d\uff1atremelimumab\uff09<\/b>\u8054\u5408\u82f1\u98de\u51e1\uff08\u901a\u7528\u540d\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff09<\/b>\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u764c\u7684\u4e9a\u6d32\u4e9a\u7ec4\u5206\u6790\u6570\u636e\u3002\u516c\u5e03\u7684\u6570\u636e\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u5728\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u57fa\u7840\u4e0a\u52a0\u7528\u5355\u6b21\u542f\u52a8\u5242\u91cf\u7684tremelimumab\uff0c\u4e2d\u56fd\u6e2f\u53f0\u5730\u533a\u4eba\u7fa4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09\u8fbe29.4\u4e2a\u6708\uff0c\u4e0e\u6574\u4e2a\u4e9a\u6d32\u4e9a\u7ec4\u7684\u6570\u636e\u57fa\u672c\u4e00\u81f4\uff0c\u8bc1\u5b9e\u4e86\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n

\u91c7\u7528\u521b\u65b0\u5242\u91cf\u548c\u7528\u836f\u65b9\u6848\u7684\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u548ctremelimumab\u7684\u8054\u5408\u6cbb\u7597\u88ab\u79f0\u4e3aSTRIDE<\/b>\u65b9\u6848\uff08<\/b>Single Tremelimumab Regular Interval Durvalumab<\/b>\uff09<\/b>\uff0c\u5305\u62ec\u9996\u6b21\u7ed9\u836f\u4ec5\u5e94\u7528\u4e00\u5242\u6297CTLA-4\u5355\u6297tremelimumab 300mg\u8054\u5408\u6297PD-L1\u5355\u6297\u5ea6\u4f10\u5229\u5c24\u5355\u62971500mg\uff0c\u968f\u540e\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u6bcf\u56db\u5468\u4e00\u6b21\u7ed9\u836f\u3002\u57fa\u4e8e\u2162\u671f\u4e34\u5e8a\u7814\u7a76HIMALAYA\u7684\u7ed3\u679c\uff0c\u8be5\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5df2\u4e8e\u4eca\u5e7410\u6708\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u6700\u5e38\u89c1\u7684\u809d\u764c\u7c7b\u578b\u2014\u2014\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c (HCC) \u7684\u6210\u5e74\u60a3\u8005\u3002<\/p>\n

\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u5168\u7403\u4eba\u7fa4\u7684\u6570\u636e\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u63a5\u53d7tremelimumab\u8054\u5408\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8622%\uff08\u57fa\u4e8e0.78\u7684\u98ce\u9669\u6bd4[HR]\uff0c95%\u7f6e\u4fe1\u533a\u95f4[CI] 0.66-0.92 p=0.0035) [1]<\/span><\/sup>\u3002\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u8bc1\u636e\u6742\u5fd7\u300b\u4e0a\u53d1\u8868\u7684\u8fd9\u4e00\u7ed3\u679c\u663e\u793a\u7ea6\u670931%\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u5728\u4e09\u5e74\u540e\u4ecd\u7136\u5b58\u6d3b\uff0c mOS\u8fbe16.4\u4e2a\u6708\uff0c\u800c\u63a5\u53d7\u7d22\u62c9\u975e\u5c3c\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4ec5\u670920%\u5728\u76f8\u540c\u7684\u968f\u8bbf\u671f\u95f4\u5185\u4ecd\u7136\u5b58\u6d3b\uff0cmOS\u4e3a13.8\u4e2a\u6708[2]<\/span><\/sup>\u3002<\/p>\n

\u809d\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u7b2c\u4e09\u5927\u539f\u56e0\uff0c\u4e5f\u662f\u7b2c\u516d\u5927\u6700\u5e38\u89c1\u7684\u764c\u75c7[3],[4]<\/span><\/sup>\u3002\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\uff0c\u6bcf\u5e74\u5927\u7ea6\u6709 8 \u4e07\u4eba\uff0c\u5728\u4e2d\u56fd\u6709 26 \u4e07\u4eba\u60a3\u6709\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c[5]<\/span><\/sup>\uff0c\u665a\u671f\u60a3\u8005 5 \u5e74\u751f\u5b58\u7387\u53ea\u6709 7%[6]<\/span><\/sup>\u3002<\/p>\n

HIMALAYA\u7814\u7a76\u5171\u7eb3\u51651,324\u540d\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u6210\u4eba\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec479\u4f8b\u4e9a\u6d32\uff08\u4e0d\u542b\u65e5\u672c\uff09\u60a3\u8005\uff08STRIDE\u65b9\u6848\u7ec4 156\u4f8b vs \u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u7ec4167\u4f8b vs \u7d22\u62c9\u975e\u5c3c\u5bf9\u7167\u7ec4156\u4f8b\uff09\u3002\u5728HIMALAYA\u7814\u7a76\u4e9a\u6d32\u4e9a\u7ec4\u4e2d\uff0c\u63a5\u53d7STRIDE\u65b9\u6848\u6cbb\u7597\u7684\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8632%\uff08\u57fa\u4e8e0.68\u7684\u98ce\u9669\u6bd4[HR]\uff0c95%\u7f6e\u4fe1\u533a\u95f4[CI] 0.52-0.89)\uff0c\u4e09\u5e74\u751f\u5b58\u7387\u8fbe32.2%\uff0cmOS\u8fbe16.5\u4e2a\u6708\uff0c\u5747\u4e0e\u5168\u7403\u4eba\u7fa4\u6570\u636e\u4e00\u81f4\u3002\u4e9a\u6d32\u4e9a\u7ec4\u4e2d\uff0c\u4e2d\u56fd\u9999\u6e2f\u548c\u53f0\u6e7e\u5730\u533a\u60a3\u8005\u5171\u7eb3\u5165141\u4f8b\uff08STRIDE\u65b9\u6848\u7ec4 56\u4f8b vs \u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u7ec442\u4f8b vs \u7d22\u62c9\u975e\u5c3c\u5bf9\u7167\u7ec443\u4f8b\uff09\uff0c\u63a5\u53d7STRIDE\u65b9\u6848\u6cbb\u7597\u7684\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8656%\uff08\u57fa\u4e8e0.44\u7684\u98ce\u9669\u6bd4[HR]\uff0c95%\u7f6e\u4fe1\u533a\u95f4[CI] 0.26-0.77)\uff0c\u4e09\u5e74\u751f\u5b58\u7387\u8fbe49.2%\uff0cmOS\u8fbe29.4\u4e2a\u6708\uff0c\u4e0e\u6574\u4e2a\u4e9a\u6d32\u4e9a\u7ec4\u7684\u6570\u636e\u57fa\u672c\u4e00\u81f4\u3002\u4e0e\u5168\u7403\u4eba\u7fa4\u76f8\u6bd4\uff0c\u4e9a\u6d32\u4e9a\u7ec4\u4e2d\u60a3\u6709\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u66f4\u9ad8\uff08\u4e9a\u6d32\u4e9a\u7ec4\uff1a62% vs \u5168\u7403\u4eba\u7fa4\uff1a31%\uff09\u3002\u5728\u4e9a\u6d32\u4e9a\u7ec4\u4e0e\u5168\u7403\u4eba\u7fa4\u4e2d\uff0c\u5206\u522b\u670916%\u548c27%\u7684\u60a3\u8005\u60a3\u6709\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08HCV\uff09\uff0c22%\u548c42%\u7684\u60a3\u8005\u4e3a\u975e\u75c5\u6bd2\u75c5\u56e0\u5f15\u8d77\u7684\u809d\u764c\u3002<\/p>\n

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\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\u9662\u957f\u6a0a\u5609\u6559\u6388\u8868\u793a\uff1a"HIMALAYA\u7814\u7a76\u4e2d\u56fd\u6e2f\u53f0\u6570\u636e\u7ed3\u679c\u7684\u516c\u5e03\u5bf9\u56fd\u5185\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u6765\u8bf4\u65e0\u7591\u662f\u4e00\u4e2a\u597d\u6d88\u606f\u3002\u9996\u5148\uff0c\u8fd9\u662f\u57fa\u4e8e\u4e2d\u56fd\u6e2f\u53f0\u60a3\u8005\u63a5\u53d7STRIDE\u65b9\u6848\u6cbb\u7597\u7684\u5206\u6790\uff0c\u6570\u636e\u7ed3\u679c\u5bf9\u4e8e\u4e2d\u56fd\u5927\u9646\u60a3\u8005\u5177\u6709\u975e\u5e38\u9ad8\u7684\u53c2\u8003\u4ef7\u503c\u548c\u610f\u4e49\u3002\u540c\u65f6\uff0c\u8fd9\u4e5f\u610f\u5473\u7740STRIDE\u65b9\u6848\u4f5c\u4e3a\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u5f97\u5230\u4e86\u5168\u7403\u4eba\u7fa4\u548c\u4e2d\u56fd\u4eba\u7fa4\u7684\u53cc\u91cd\u9a8c\u8bc1\uff0c\u7597\u6548\u548c\u5b89\u5168\u6027\u5747\u5f97\u5230\u4e86\u5145\u5206\u7684\u8bc1\u5b9e\u3002STRIDE\u65b9\u6848\u4f5c\u4e3a\u8fc4\u4eca\u4e3a\u6b62\u552f\u4e00[*]\u4e00\u4e2a\u83b7\u5f97\u53cc\u514d\u6cbb\u7597\u53d6\u5f97\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u521b\u65b0\u65b9\u6848\uff0c\u4e3a\u4e2d\u56fd\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5c06\u52a9\u529b\u300a"\u5065\u5eb7\u4e2d\u56fd2030"\u89c4\u5212\u7eb2\u8981\u300b\u4f1f\u5927\u76ee\u6807\u7684\u5b9e\u73b0\u3002"<\/p>\n

\u963f\u65af\u5229\u5eb7\u4e2d\u56fd\u80bf\u7624\u4e8b\u4e1a\u90e8\u603b\u7ecf\u7406\u9648\u5eb7\u4f1f\u8868\u793a\uff1a"\u8fc7\u53bb\uff0c\u809d\u764c\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u6709\u9650\uff0c\u9884\u540e\u4e5f\u4e0d\u7406\u60f3\u3002\u6b64\u6b21HIMALAYA\u7814\u7a76\u516c\u5e03\u7684\u4e9a\u7ec4\u6570\u636e\u7ed3\u679c\u8868\u660e\uff0c\u76f8\u6bd4\u5168\u7403\u4eba\u7fa4\uff0c\u4e2d\u56fd\u6e2f\u53f0\u5730\u533a\u4eba\u7fa4\u7684\u603b\u751f\u5b58\u671f\u83b7\u76ca\u66f4\u4e3a\u663e\u8457\uff0c\u8fd150%\u7684\u60a3\u8005\u751f\u5b58\u8fbe\u5230\u4e863\u5e74\uff0c\u6b7b\u4ea1\u98ce\u9669\u4e5f\u6709\u66f4\u4e3a\u663e\u8457\u7684\u964d\u4f4e\u3002\u8fd9\u610f\u5473\u7740\u4e2d\u56fd\u809d\u764c\u60a3\u8005\u80fd\u66f4\u597d\u5730\u4ece\u8fd9\u79cd\u6cbb\u7597\u65b9\u6848\u4e2d\u83b7\u76ca\uff0c\u6709\u671b\u5b9e\u73b0\u957f\u671f\u751f\u5b58\u3002\u540c\u65f6\uff0c\u8fd9\u4e5f\u66f4\u52a0\u575a\u5b9a\u4e86\u6211\u4eec\u901a\u8fc7\u6301\u7eed\u4e0d\u65ad\u7684\u7814\u53d1\u521b\u65b0\uff0c\u60e0\u53ca\u9664\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u5375\u5de2\u764c\u3001\u524d\u5217\u817a\u764c\u4ee5\u5916\u66f4\u5e7f\u6cdb\u7684\u80bf\u7624\u60a3\u8005\u7684\u51b3\u5fc3\uff0c\u4ee5\u53ca\u6311\u6218\u6cbb\u7597\u9884\u671f\u5e76\u6539\u53d8\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u6d88\u5316\u9053\u80bf\u7624\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u5c40\u7684\u96c4\u5fc3\u3002\u6211\u4eec\u671f\u5f85\u8fd9\u4e00\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u5728\u4e2d\u56fd\u65e9\u65e5\u83b7\u6279\uff0c\u5c3d\u65e9\u60e0\u53ca\u4e2d\u56fd\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002"<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/b><\/p>\n

    \n
  1. Imfinzi and Imjudo US prescribing information; 2022.<\/li>\n
  2. Abou-Alfa, et al. Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma. NEJM Evid<\/i>. 2022;1-12.<\/li>\n
  3. ASCO. Liver Cancer: View All Pages. Available at: https:\/\/www.cancer.net\/cancer-types\/liver-cancer\/view-all. Accessed October 2022<\/span><\/a>.<\/li>\n
  4. WHO. Liver Cancer Fact Sheet. Available at: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/11-Liver-fact-sheet.pdf<\/a>. Accessed December 2022<\/span>.<\/li>\n
  5. AstraZeneca data on file. Kantar Health. 2021.<\/li>\n
  6. Sayiner M, et al.<\/i> Disease Burden of Hepatocellular Carcinoma: A Global Perspective. Digestive Diseases and Sciences.<\/i> 2019; 64: 910-917.<\/li>\n
  7. WHO. World Cancer Fact Sheet. Available at: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/39-All-cancers-fact-sheet.pdf<\/a>. Accessed December 2022<\/span>.<\/li>\n<\/ol>\n

     <\/p>\n

    \n\n\n\n
    \n

    [*] \u622a\u81f32022\u5e7412\u67085\u65e5<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n","protected":false},"excerpt":{"rendered":"

    \u2162\u671f\u4e34\u5e8a\u7814\u7a76HIMALAYA\u7684\u4e9a\u6d32\u4e9a\u7ec4\u4e2d\u56fd\u6e2f\u53f0\u6570\u636e\u663e\u793a\uff0c\u5355\u6b21\u542f\u52a8\u5242\u91cf\u7684Imjudo\u8054\u5408\u82f1\u98de\u51e1\u53ef\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e56% \u4e0a\u6d772022\u5e7412\u67086\u65e5 \/\u7f8e\u901a\u793e\/ — 2022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u4e9a\u6d32\u5927\u4f1a\/\u5e74\u4f1a\uff08ESMO ASIA 2022\uff09\u4e8e12\u67082\u65e5\u6b63\u5f0f\u516c\u5e03\u4e86\u5728\u2162\u671f\u4e34\u5e8a\u7814\u7a76HIMALAYA\u4e2d\uff0c\u963f\u65af\u5229\u5eb7\u516c\u53f8\u7684Imjudo\uff08\u901a\u7528\u540d\uff1atremelimumab\uff09\u8054\u5408\u82f1\u98de\u51e1\uff08\u901a\u7528\u540d\uff1a\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff09\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u764c\u7684\u4e9a\u6d32\u4e9a\u7ec4\u5206\u6790\u6570\u636e\u3002\u516c\u5e03\u7684\u6570\u636e\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u5728\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u57fa\u7840\u4e0a\u52a0\u7528\u5355\u6b21\u542f\u52a8\u5242\u91cf\u7684tremelimumab\uff0c\u4e2d\u56fd\u6e2f\u53f0\u5730\u533a\u4eba\u7fa4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09\u8fbe29.4\u4e2a\u6708\uff0c\u4e0e\u6574\u4e2a\u4e9a\u6d32\u4e9a\u7ec4\u7684\u6570\u636e\u57fa\u672c\u4e00\u81f4\uff0c\u8bc1\u5b9e\u4e86\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u751f\u5b58\u83b7\u76ca\u3002 \u91c7\u7528\u521b\u65b0\u5242\u91cf\u548c\u7528\u836f\u65b9\u6848\u7684\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u548ctremelimumab\u7684\u8054\u5408\u6cbb\u7597\u88ab\u79f0\u4e3aSTRIDE\u65b9\u6848\uff08Single Tremelimumab Regular Interval Durvalumab\uff09\uff0c\u5305\u62ec\u9996\u6b21\u7ed9\u836f\u4ec5\u5e94\u7528\u4e00\u5242\u6297CTLA-4\u5355\u6297tremelimumab 300mg\u8054\u5408\u6297PD-L1\u5355\u6297\u5ea6\u4f10\u5229\u5c24\u5355\u62971500mg\uff0c\u968f\u540e\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u6bcf\u56db\u5468\u4e00\u6b21\u7ed9\u836f\u3002\u57fa\u4e8e\u2162\u671f\u4e34\u5e8a\u7814\u7a76HIMALAYA\u7684\u7ed3\u679c\uff0c\u8be5\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5df2\u4e8e\u4eca\u5e7410\u6708\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u6700\u5e38\u89c1\u7684\u809d\u764c\u7c7b\u578b\u2014\u2014\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c (HCC) \u7684\u6210\u5e74\u60a3\u8005\u3002 \u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u5168\u7403\u4eba\u7fa4\u7684\u6570\u636e\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u63a5\u53d7tremelimumab\u8054\u5408\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8622%\uff08\u57fa\u4e8e0.78\u7684\u98ce\u9669\u6bd4[HR]\uff0c95%\u7f6e\u4fe1\u533a\u95f4[CI] 0.66-0.92 p=0.0035) [1]\u3002\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u8bc1\u636e\u6742\u5fd7\u300b\u4e0a\u53d1\u8868\u7684\u8fd9\u4e00\u7ed3\u679c\u663e\u793a\u7ea6\u670931%\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u5728\u4e09\u5e74\u540e\u4ecd\u7136\u5b58\u6d3b\uff0c mOS\u8fbe16.4\u4e2a\u6708\uff0c\u800c\u63a5\u53d7\u7d22\u62c9\u975e\u5c3c\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4ec5\u670920%\u5728\u76f8\u540c\u7684\u968f\u8bbf\u671f\u95f4\u5185\u4ecd\u7136\u5b58\u6d3b\uff0cmOS\u4e3a13.8\u4e2a\u6708[2]\u3002 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\u53c2\u8003\u6587\u732e\uff1a Imfinzi and Imjudo US prescribing information; 2022.… Read 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