{"id":87084,"date":"2022-12-02T15:36:00","date_gmt":"2022-12-02T08:36:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022120215360087084"},"modified":"2022-12-02T22:59:23","modified_gmt":"2022-12-02T14:59:23","slug":"%e9%bd%90%e9%b2%81%e5%88%b6%e8%8d%afql1706%e6%b2%bb%e7%96%97%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e7%9a%84ii%e6%9c%9f%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e7%bb%93%e6%9e%9c%e5%85%ac","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022120215360087084","title":{"rendered":"\u9f50\u9c81\u5236\u836fQL1706\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684II\u671f\u7814\u7a76\u6700\u65b0\u7ed3\u679c\u516c\u5e03"},"content":{"rendered":"

\u6d4e\u5357<\/span>2022\u5e7412\u67082\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u9f50\u9c81\u5236\u836f\u662f\u4e2d\u56fd\u9886\u5148\u7684\u5927\u578b\u7efc\u5408\u6027\u73b0\u4ee3\u5236\u836f\u4f01\u4e1a\u4e4b\u4e00\uff0c\u96c6\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u6210\u54c1\u5236\u5242\u53ca\u539f\u6599\u836f\u4e8e\u4e00\u4f53\u30022022\u5e7412\u67082\u65e5\uff0c\u5728\u6b27\u6d32\u80bf\u7624\u533b\u5b66\u5b66\u4f1a(ESMO)2022\u4e9a\u6d32\u5927\u4f1a\u4e0a\uff0c\u9f50\u9c81\u5236\u836f\u4ee5\u58c1\u62a5\u5f62\u5f0f\uff08325P\u3001332P)\u516c\u5e03\u4e86QL1706\u8054\u5408\u5316\u7597+\/-\u8d1d\u4f10\u6cbb\u7597\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n

\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

QL1706\u662f\u4e00\u79cd\u65b0\u578b\u6297PD-1 IgG4\u548c\u6297CTLA-4 IgG1\u7ec4\u5408\u6297\u4f53\uff0c\u53ef\u540c\u65f6\u963b\u65adPD-1\u548cCTLA-4\u4e24\u4e2a\u9776\u70b9\u3002I\u671f\u7814\u7a76\u4e2d\uff0cQL1706\u5728\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5728\u5185\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u7597\u6548\u3002\u672c\u6b21\u62a5\u544a\u7684\u662f\u4e00\u9879QL1706\u8054\u5408\u5316\u7597+\/-\u8d1d\u4f10\u6cbb\u7597\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684II\u671f\u3001\u5f00\u653e\u3001\u5355\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff08NCT05329025\uff09\u3002\u7814\u7a76\u5bf9\u8c61\u4e3a\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u91ce\u751f\u578b\u548c\u7a81\u53d8\u578b\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/p>\n

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\n

\"\u56fe1<\/a>
\u56fe1 \u9776\u75c5\u7076\u81ea\u57fa\u7ebf\u7684\u6700\u4f73\u53d8\u5316\uff08EGFR\u91ce\u751f\u578b\u4eba\u7fa4\uff09<\/span><\/p>\n<\/p><\/div>\n

\u5171\u670931\u4f8bEGFR\u7a81\u53d8\u578b\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5165\u7ec4\uff0c\u5168\u90e8\u60a3\u8005\u4e3a\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08EGFR\uff09\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242+\/-\u8d1d\u4f10\u73e0\u5355\u6297\/\u5b89\u7f57\u66ff\u5c3c\u6cbb\u7597\u4e0d\u8010\u53d7\u6216\u63a5\u53d7\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3002\u60a3\u8005\u63a5\u53d7QL1706 5mg\/kg\u8054\u5408\u5316\u7597\uff08\u57f9\u7f8e\u66f2\u585e\u52a0\u5361\u94c2\uff09\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\uff08Q3W\uff09\u8fdb\u884c4\u4e2a\u5468\u671f\uff0c\u4e4b\u540e\u63a5\u53d7QL1706 5mg\/kg\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u7ef4\u6301\u6cbb\u7597\uff08Q3W\uff09\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u5176\u4ed6\u505c\u836f\u4e8b\u4ef6\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a5.75\u4e2a\u6708\u3002ORR\u4e3a64.5%\uff0820\/31\uff09\uff0cDCR\u4e3a93.5%\uff0829\/31\uff09\u3002PFS\u5c1a\u672a\u8fbe\u5230\uff0c6\u4e2a\u6708\u7684PFS\u7387\u4e3a61.3%\u3002<\/p>\n

\n

\"\u56fe2<\/a>
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\u603b\u4f53\u4e0a\uff0cQL1706\u8054\u5408\u5316\u7597\u663e\u793a\u51fa\u826f\u597d\u3001\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u5176\u5b89\u5168\u8c31\u4e0e\u5316\u7597\u6216\u6297PD-1\u8054\u5408\u6297CTLA-4\u6cbb\u7597\u7684\u62a5\u544a\u4e00\u81f4\u3002<\/p>\n

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<\/div>\n","protected":false},"excerpt":{"rendered":"

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