{"id":85922,"date":"2022-11-22T13:26:00","date_gmt":"2022-11-22T06:26:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022112213260085922"},"modified":"2022-11-23T22:39:09","modified_gmt":"2022-11-23T14:39:09","slug":"%e9%9d%9e%e8%82%bf%e7%98%a4%e9%a2%86%e5%9f%9f%e5%86%8d%e4%b8%8b%e4%b8%80%e5%9f%8e%ef%bc%81%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afeed%e6%8a%91%e5%88%b6%e5%89%82apg-5918%e6%b2%bb%e7%96%97%e8%b4%ab%e8%a1%80","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022112213260085922","title":{"rendered":"\u975e\u80bf\u7624\u9886\u57df\u518d\u4e0b\u4e00\u57ce\uff01\u4e9a\u76db\u533b\u836fEED\u6291\u5236\u5242APG-5918\u6cbb\u7597\u8d2b\u8840\u9002\u5e94\u75c7IND\u83b7CDE\u53d7\u7406"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Ascentage_Pharma_Logo-19.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p><span class=\"legendSpanClass\">\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e02<\/span><span class=\"legendSpanClass\">2022\u5e7411\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;<b> \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u751f\u7269\u533b\u836f\u4f01\u4e1a &#8212; <\/b>\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5728\u7814\u539f\u521b\u65b0\u836f\u80da\u80ce\u5916\u80da\u5c42\u53d1\u80b2\u86cb\u767d\uff08EED\uff09\u6291\u5236\u5242APG-5918\u6cbb\u7597\u8d2b\u8840\u76f8\u5173\u75be\u75c5\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u5c06\u5f00\u542f\u975e\u80bf\u7624\u9886\u57df\u63a2\u7d22\u3002APG-5918\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u4e2d\u56fd\u539f\u7814EED\u6291\u5236\u5242\uff0c\u6b63\u5728\u4e2d\u7f8e\u540c\u6b65\u63a8\u8fdb\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u6216\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30APG-5918\u5728\u6210\u4eba\u5065\u5eb7\u53d7\u8bd5\u8005\u548c\u8d2b\u8840\u53d7\u8bd5\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4ee5\u53ca\u6297\u8d2b\u8840\u7684\u521d\u6b65\u7597\u6548\u3002\u8be5\u7814\u7a76\u5c06\u7eb3\u5165\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u3001\u80be\u6027\u8d2b\u8840\u53ca\u5176\u4ed6\u76f8\u5173\u8d2b\u8840\u7684\u53d7\u8bd5\u8005\u3002<\/p>\n<p>\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u662f\u4e00\u79cd\u5728\u5168\u7403\u5f71\u54cd\u8303\u56f4\u5e7f\u3001\u7d2f\u79ef\u60a3\u75c5\u4eba\u6570\u591a\u4e14\u4e25\u91cd\u5a01\u80c1\u4eba\u7c7b\u5065\u5eb7\u7684\u9057\u4f20\u6027\u8840\u6db2\u75c5\u3002\u5168\u7403\u4eba\u53e3\u76841-5%\u662f\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u57fa\u56e0\u643a\u5e26\u8005\uff0c\u5176\u4e2d\u4e2d\u56fd\u7ea6\u67092.21% (95%CI: 1.93~2.48)\uff0c\u4e14\u5728\u5357\u65b9\u5730\u533a\u5c24\u4e3a\u591a\u89c1<sup>[1]<\/sup>\u3002\u9488\u5bf9\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u4f20\u7edf\u7597\u6cd5\u4ecd\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u6027\uff0c\u5c24\u5176\u662f\u8f93\u8840\u4f9d\u8d56\u6027\u7684\u60a3\u8005\uff0c\u8eab\u5904\u6cbb\u7597\u65b9\u6848\u532e\u4e4f\u3001\u75be\u75c5\u62a4\u7406\u548c\u8d39\u7528\u8d1f\u62c5\u7b49\u4e25\u5cfb\u5c40\u9762\uff0c\u591a\u91cd\u56e0\u7d20\u7684\u9650\u5236\u4f7f\u60a3\u8005\u7684\u6cbb\u7597\u4f9d\u4ece\u6027\u5dee\uff0c\u751f\u547d\u8d28\u91cf\u4e5f\u666e\u904d\u4e0d\u9ad8\u3002\u636e\u7edf\u8ba1\uff0c3.9%\u7684\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u57fa\u56e0\u60a3\u8005\u5904\u5728\u4f4e\u6536\u5165\u6216\u4e2d\u7b49\u6536\u5165\u7684\u56fd\u5bb6\uff0c\u56e0\u6b64\uff0c\u4ecd\u9700\u5bfb\u627e\u66f4\u597d\u3001\u66f4\u6807\u51c6\u53ca\u6613\u4e8e\u5b9e\u65bd\u7684\u6cbb\u7597\u65b9\u6cd5\u7528\u4e8e\u8d44\u6e90\u7f3a\u4e4f\u7684\u56fd\u5bb6<sup>[2]<\/sup>\u3002<\/p>\n<p>\u80be\u6027\u8d2b\u8840\u6307\u7684\u662f\u5404\u79cd\u80be\u810f\u75be\u75c5\u5bfc\u81f4\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08EPO\uff09\u7edd\u5bf9\u6216\u76f8\u5bf9\u751f\u6210\u4e0d\u8db3\uff0c\u4ee5\u53ca\u5c3f\u6bd2\u75c7\u6bd2\u7d20\u5f71\u54cd\u7ea2\u7ec6\u80de\u751f\u6210\u53ca\u5176\u5bff\u547d\u800c\u53d1\u751f\u7684\u8d2b\u8840\uff0c\u5728\u6162\u6027\u80be\u810f\u75be\u75c5\uff08CKD\uff09\u60a3\u8005\u4e2d\u666e\u904d\u5b58\u5728\uff0c\u5e76\u968f\u7740CKD\u8fdb\u5c55\u800c\u589e\u52a0<sup>[3]<\/sup>\u3002\u9664\u8f93\u8840\u548c\u94c1\u5242\u6cbb\u7597\u5916\uff0c\u6307\u5357\u63a8\u8350\u7684\u6cbb\u7597\u63aa\u65bd\u8fd8\u5305\u62ec\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08ESAs\uff09\u548c\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u812f\u6c28\u9170\u7f9f\u5316\u9176\u6291\u5236\u5242\uff08HIF-PHI\uff09\u7c7b\u836f\u7269\uff0c\u8fd9\u4e24\u79cd\u836f\u7269\u53ef\u660e\u663e\u51cf\u5c11CKD\u60a3\u8005\u7684\u8f93\u8840\u6b21\u6570\u53ca\u51cf\u8f7b\u8d2b\u8840\u76f8\u5173\u75c7\u72b6\uff0c\u4f46\u4ecd\u5b58\u5728\u4e00\u5b9a\u7684\u5b89\u5168\u6027\u987e\u8651\u3002<\/p>\n<p>APG-5918\u662f\u4e9a\u76db\u533b\u836f\u5728\u7814\u5177\u6709\u53e3\u670d\u6d3b\u6027\u3001\u65b0\u578b\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027EED\u86cb\u767d\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u5177\u6709\u9ad8\u5ea6\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u901a\u8fc7\u8c03\u8282\u80bf\u7624\u7ec4\u7ec7\u8868\u89c2\u9057\u4f20\u5b66\u53ca\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5728\u8840\u6db2\u80bf\u7624\u3001\u5b9e\u4f53\u7624\u548c\u975e\u80bf\u7624\u9002\u5e94\u75c7\u4e0a\u5177\u6709\u5e7f\u9614\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002APG-5918\u53ef\u4e0e\u7ec4\u86cb\u767dH3\u7b2c27\u4f4d\u8d56\u6c28\u9178\u4e09\u7532\u57fa\u5316\uff08H3K27me3\uff09\u7ade\u4e89\u7ed3\u5408EED\u86cb\u767d\uff0c\u6291\u5236PRC2\u590d\u5408\u7269\u7684\u7532\u57fa\u8f6c\u79fb\u9176\u6d3b\u6027\uff0c\u89e3\u9664\u5bf9\u8840\u7ea2\u86cb\u767d\u57fa\u56e0\u7684\u8f6c\u5f55\u6291\u5236\uff0c\u4ece\u800c\u5bf9\u8d2b\u8840\u75be\u75c5\u4ea7\u751f\u7597\u6548\u3002<\/p>\n<p>\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cAPG-5918\u53ef\u663e\u8457\u6291\u5236\u4ebaCD34+\u9020\u8840\u5e72\u7ec6\u80de\u7ea2\u7cfb\u5206\u5316\u8fc7\u7a0b\u4e2dH3K27me3\u6c34\u5e73\uff0c\u5242\u91cf\u4f9d\u8d56\u6027\u5730\u4e0a\u8c03\u03b3-\u73e0\u86cb\u767d\u7f16\u7801\u57fa\u56e0\uff08HBG\uff09\u4ee5\u53ca\u03b2-\u73e0\u86cb\u767d\u7f16\u7801\u57fa\u56e0\uff08HBB\uff09\u7684mRNA\u6c34\u5e73\uff0c\u5e76\u4e0a\u8c03\u80ce\u513f\u8840\u7ea2\u86cb\u767d\uff08Fetal hemoglobin\uff0cHbF\uff09\u548c\u603b\u8840\u7ea2\u86cb\u767d\uff08Hemoglobin\uff0cHb\uff09\u7684\u8868\u8fbe\u6c34\u5e73\uff1bAPG-5918\u5355\u836f\u5728\u817a\u560c\u5464\u8bf1\u5bfc\u5927\u9f20\u80be\u6027\u8d2b\u8840\u6a21\u578b\u4e2d\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u6297\u8d2b\u8840\u836f\u6548\u4f5c\u7528\uff0c\u5927\u9f20\u4f53\u91cd\u4ee5\u53ca\u5404\u9879\u8d2b\u8840\u76f8\u5173\u7684\u8840\u5e38\u89c4\u53c2\u6570\u5728\u7ed9\u836f\u540e\u5747\u5f97\u5230\u663e\u8457\u6539\u5584\u3002\u5728\u8f83\u9ad8\u5242\u91cf\u7ec4\u6297\u8d2b\u8840\u6548\u679c\u4e0e\u4e34\u5e8a\u6807\u51c6\u7597\u6cd5EPO\u76f8\u5f53\uff1b\u5e76\u4e14\u5728\u4e2d\u5242\u91cf\u7ec4\u4e0eEPO\u8054\u7528\u540e\uff0c\u4e0e\u5355\u836f\u7ec4\u76f8\u6bd4\u53ef\u8fdb\u4e00\u6b65\u6539\u5584\u5927\u9f20\u7684\u4f53\u91cd\u4ee5\u53ca\u5404\u9879\u8d2b\u8840\u76f8\u5173\u7684\u8840\u5e38\u89c4\u53c2\u6570\uff0c\u81f3\u5b9e\u9a8c\u7ed3\u675f\u65f6\uff0c\u8054\u5408\u7ec4\u7684\u5927\u9f20\u5404\u9879\u8840\u5e38\u89c4\u53c2\u6570\u5747\u5df2\u6062\u590d\u81f3\u5bf9\u7167\u7ec4\u7684\u6c34\u5e73\u3002<\/p>\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u9664APG-5918\u5916\uff0c\u5168\u7403\u5c42\u9762\u67094\u6b3e\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684EED\u6291\u5236\u5242\u3002\u5176\u4e2dFulcrum Therapeutics\u7684FTX-6058\u662f\u76ee\u524d\u552f\u4e00\u5904\u4e8e\u4e34\u5e8aI\u671f\u8bd5\u9a8c\u9636\u6bb5\u9488\u5bf9\u975e\u80bf\u7624\u9002\u5e94\u75c7\uff08\u5982\u9570\u72b6\u7ec6\u80de\u8d2b\u8840\u548c\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\uff09\u7684\u5c0f\u5206\u5b50EED\u6291\u5236\u5242\u3002<\/p>\n<p>\u5e7f\u897f\u533b\u79d1\u5927\u5b66\u5730\u4e2d\u6d77\u8d2b\u8840\u9632\u6cbb\u7814\u7a76\u6240\u526f\u6240\u957f\u3001\u5730\u4e2d\u6d77\u8d2b\u8840\u9632\u6cbb\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u9648\u840d\u6559\u6388\u8868\u793a\uff1a&quot;\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u548c\u80be\u6027\u8d2b\u8840\u60a3\u8005\u90fd\u5b58\u5728\u5de8\u5927\u7684\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002\u4e9a\u76db\u533b\u836f\u5728\u7814\u7684APG-5918\u4ee5\u5168\u65b0\u7684\u4f5c\u7528\u673a\u5236\uff0c\u6709\u671b\u4e3a\u76f8\u5173\u8d2b\u8840\u7684\u6cbb\u7597\u63d0\u4f9b\u4e00\u4e2a\u5d2d\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u6211\u4eec\u671f\u5f85\u901a\u8fc7\u624e\u5b9e\u6709\u6548\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u6700\u7ec8\u80fd\u591f\u4e3a\u8d2b\u8840\u60a3\u8005\u63d0\u4f9b\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002&quot;<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a&quot;APG-5918\u662f\u56fd\u5185\u9996\u4e2aEED\u6291\u5236\u5242\uff0c\u6781\u5177\u4e34\u5e8a\u5f00\u53d1\u524d\u666f\u4e0e\u4ef7\u503c\uff0c\u5e76\u5728\u76f8\u5173\u7814\u7a76\u4e2d\u5448\u73b0\u2018Best-in-class&#8217;\u6f5c\u529b\u3002\u6211\u4eec\u5c06\u52a0\u901f\u63a8\u8fdbAPG-5918\u5728\u8d2b\u8840\u76f8\u5173\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u4e3a\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002&quot;<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<br \/><\/b>1.&nbsp;&nbsp;&nbsp; Shang, Peng et al. 2017, \u4e2d\u534e\u533b\u5b66\u4f1a\u533b\u5b66\u9057\u4f20\u5b66\u5206\u4f1a\u9057\u4f20\u75c5\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u64b0\u5199\u7ec4 2020<br \/>2.&nbsp;&nbsp;&nbsp; Thalassemia<br \/>3.&nbsp;&nbsp;&nbsp; \u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u80be\u810f\u5185\u79d1\u533b\u5e08\u5206\u4f1a\u80be\u6027\u8d2b\u8840\u6307\u5357\u5de5\u4f5c\u7ec4&nbsp;2021<\/p>\n<p><b>\u5173\u4e8e\u4e9a\u76db\u533b\u836f\uff08<\/b><b>6855.HK\uff09<\/b><\/p>\n<p>\u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u6700\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67099\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5550\u591a\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7528\u4e8e\u6cbb\u7597\u8010\u836f\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\uff09\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9716\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c2\u9879FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u4ee5\u53ca2\u9879FDA\u513f\u7ae5\u7f55\u89c1\u75c5\u8d44\u683c\u8ba4\u8bc1\u3002\u516c\u53f8\u5148\u540e\u627f\u62c5\u591a\u9879\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff0c\u5176\u4e2d&quot;\u91cd\u5927\u65b0\u836f\u521b\u5236&quot;\u4e13\u98795\u9879\uff0c\u5305\u62ec1\u9879&quot;\u4f01\u4e1a\u521b\u65b0\u836f\u7269\u5b75\u5316\u57fa\u5730&quot;\u53ca4\u9879&quot;\u521b\u65b0\u836f\u7269\u7814\u53d1&quot;\uff0c\u53e6\u5916\u627f\u62c5&quot;\u91cd\u5927\u4f20\u67d3\u75c5\u9632\u6cbb&quot;\u4e13\u98791\u9879\u3002<\/p>\n<p>\u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0eUNITY\u3001MD Anderson\u3001\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u4e1c\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u7b49\u9886\u5148\u7684\u751f\u7269\u6280\u672f\u53ca\u533b\u836f\u516c\u53f8\u3001\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u4e30\u5bcc\u7684\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u7ecf\u9a8c\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u540c\u65f6\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6807\u51c6\u6253\u9020\u540e\u671f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u53ca\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c&quot;\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42&quot;\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022022\u5e7411\u670822\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u751f\u7269\u533b\u836f\u4f01\u4e1a &#8212; \u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5728\u7814\u539f\u521b\u65b0\u836f\u80da\u80ce\u5916\u80da\u5c42\u53d1\u80b2\u86cb\u767d\uff08EED\uff09\u6291\u5236\u5242APG-5918\u6cbb\u7597\u8d2b\u8840\u76f8\u5173\u75be\u75c5\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u5c06\u5f00\u542f\u975e\u80bf\u7624\u9886\u57df\u63a2\u7d22\u3002APG-5918\u662f\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u4e2d\u56fd\u539f\u7814EED\u6291\u5236\u5242\uff0c\u6b63\u5728\u4e2d\u7f8e\u540c\u6b65\u63a8\u8fdb\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u6216\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u4e34\u5e8a\u7814\u7a76\u3002 \u8fd9\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30APG-5918\u5728\u6210\u4eba\u5065\u5eb7\u53d7\u8bd5\u8005\u548c\u8d2b\u8840\u53d7\u8bd5\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4ee5\u53ca\u6297\u8d2b\u8840\u7684\u521d\u6b65\u7597\u6548\u3002\u8be5\u7814\u7a76\u5c06\u7eb3\u5165\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u3001\u80be\u6027\u8d2b\u8840\u53ca\u5176\u4ed6\u76f8\u5173\u8d2b\u8840\u7684\u53d7\u8bd5\u8005\u3002 \u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u662f\u4e00\u79cd\u5728\u5168\u7403\u5f71\u54cd\u8303\u56f4\u5e7f\u3001\u7d2f\u79ef\u60a3\u75c5\u4eba\u6570\u591a\u4e14\u4e25\u91cd\u5a01\u80c1\u4eba\u7c7b\u5065\u5eb7\u7684\u9057\u4f20\u6027\u8840\u6db2\u75c5\u3002\u5168\u7403\u4eba\u53e3\u76841-5%\u662f\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u57fa\u56e0\u643a\u5e26\u8005\uff0c\u5176\u4e2d\u4e2d\u56fd\u7ea6\u67092.21% (95%CI: 1.93~2.48)\uff0c\u4e14\u5728\u5357\u65b9\u5730\u533a\u5c24\u4e3a\u591a\u89c1[1]\u3002\u9488\u5bf9\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u4f20\u7edf\u7597\u6cd5\u4ecd\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u6027\uff0c\u5c24\u5176\u662f\u8f93\u8840\u4f9d\u8d56\u6027\u7684\u60a3\u8005\uff0c\u8eab\u5904\u6cbb\u7597\u65b9\u6848\u532e\u4e4f\u3001\u75be\u75c5\u62a4\u7406\u548c\u8d39\u7528\u8d1f\u62c5\u7b49\u4e25\u5cfb\u5c40\u9762\uff0c\u591a\u91cd\u56e0\u7d20\u7684\u9650\u5236\u4f7f\u60a3\u8005\u7684\u6cbb\u7597\u4f9d\u4ece\u6027\u5dee\uff0c\u751f\u547d\u8d28\u91cf\u4e5f\u666e\u904d\u4e0d\u9ad8\u3002\u636e\u7edf\u8ba1\uff0c3.9%\u7684\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u57fa\u56e0\u60a3\u8005\u5904\u5728\u4f4e\u6536\u5165\u6216\u4e2d\u7b49\u6536\u5165\u7684\u56fd\u5bb6\uff0c\u56e0\u6b64\uff0c\u4ecd\u9700\u5bfb\u627e\u66f4\u597d\u3001\u66f4\u6807\u51c6\u53ca\u6613\u4e8e\u5b9e\u65bd\u7684\u6cbb\u7597\u65b9\u6cd5\u7528\u4e8e\u8d44\u6e90\u7f3a\u4e4f\u7684\u56fd\u5bb6[2]\u3002 \u80be\u6027\u8d2b\u8840\u6307\u7684\u662f\u5404\u79cd\u80be\u810f\u75be\u75c5\u5bfc\u81f4\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08EPO\uff09\u7edd\u5bf9\u6216\u76f8\u5bf9\u751f\u6210\u4e0d\u8db3\uff0c\u4ee5\u53ca\u5c3f\u6bd2\u75c7\u6bd2\u7d20\u5f71\u54cd\u7ea2\u7ec6\u80de\u751f\u6210\u53ca\u5176\u5bff\u547d\u800c\u53d1\u751f\u7684\u8d2b\u8840\uff0c\u5728\u6162\u6027\u80be\u810f\u75be\u75c5\uff08CKD\uff09\u60a3\u8005\u4e2d\u666e\u904d\u5b58\u5728\uff0c\u5e76\u968f\u7740CKD\u8fdb\u5c55\u800c\u589e\u52a0[3]\u3002\u9664\u8f93\u8840\u548c\u94c1\u5242\u6cbb\u7597\u5916\uff0c\u6307\u5357\u63a8\u8350\u7684\u6cbb\u7597\u63aa\u65bd\u8fd8\u5305\u62ec\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08ESAs\uff09\u548c\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u812f\u6c28\u9170\u7f9f\u5316\u9176\u6291\u5236\u5242\uff08HIF-PHI\uff09\u7c7b\u836f\u7269\uff0c\u8fd9\u4e24\u79cd\u836f\u7269\u53ef\u660e\u663e\u51cf\u5c11CKD\u60a3\u8005\u7684\u8f93\u8840\u6b21\u6570\u53ca\u51cf\u8f7b\u8d2b\u8840\u76f8\u5173\u75c7\u72b6\uff0c\u4f46\u4ecd\u5b58\u5728\u4e00\u5b9a\u7684\u5b89\u5168\u6027\u987e\u8651\u3002 APG-5918\u662f\u4e9a\u76db\u533b\u836f\u5728\u7814\u5177\u6709\u53e3\u670d\u6d3b\u6027\u3001\u65b0\u578b\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027EED\u86cb\u767d\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u5177\u6709\u9ad8\u5ea6\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u901a\u8fc7\u8c03\u8282\u80bf\u7624\u7ec4\u7ec7\u8868\u89c2\u9057\u4f20\u5b66\u53ca\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5728\u8840\u6db2\u80bf\u7624\u3001\u5b9e\u4f53\u7624\u548c\u975e\u80bf\u7624\u9002\u5e94\u75c7\u4e0a\u5177\u6709\u5e7f\u9614\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002APG-5918\u53ef\u4e0e\u7ec4\u86cb\u767dH3\u7b2c27\u4f4d\u8d56\u6c28\u9178\u4e09\u7532\u57fa\u5316\uff08H3K27me3\uff09\u7ade\u4e89\u7ed3\u5408EED\u86cb\u767d\uff0c\u6291\u5236PRC2\u590d\u5408\u7269\u7684\u7532\u57fa\u8f6c\u79fb\u9176\u6d3b\u6027\uff0c\u89e3\u9664\u5bf9\u8840\u7ea2\u86cb\u767d\u57fa\u56e0\u7684\u8f6c\u5f55\u6291\u5236\uff0c\u4ece\u800c\u5bf9\u8d2b\u8840\u75be\u75c5\u4ea7\u751f\u7597\u6548\u3002 \u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cAPG-5918\u53ef\u663e\u8457\u6291\u5236\u4ebaCD34+\u9020\u8840\u5e72\u7ec6\u80de\u7ea2\u7cfb\u5206\u5316\u8fc7\u7a0b\u4e2dH3K27me3\u6c34\u5e73\uff0c\u5242\u91cf\u4f9d\u8d56\u6027\u5730\u4e0a\u8c03\u03b3-\u73e0\u86cb\u767d\u7f16\u7801\u57fa\u56e0\uff08HBG\uff09\u4ee5\u53ca\u03b2-\u73e0\u86cb\u767d\u7f16\u7801\u57fa\u56e0\uff08HBB\uff09\u7684mRNA\u6c34\u5e73\uff0c\u5e76\u4e0a\u8c03\u80ce\u513f\u8840\u7ea2\u86cb\u767d\uff08Fetal hemoglobin\uff0cHbF\uff09\u548c\u603b\u8840\u7ea2\u86cb\u767d\uff08Hemoglobin\uff0cHb\uff09\u7684\u8868\u8fbe\u6c34\u5e73\uff1bAPG-5918\u5355\u836f\u5728\u817a\u560c\u5464\u8bf1\u5bfc\u5927\u9f20\u80be\u6027\u8d2b\u8840\u6a21\u578b\u4e2d\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u6297\u8d2b\u8840\u836f\u6548\u4f5c\u7528\uff0c\u5927\u9f20\u4f53\u91cd\u4ee5\u53ca\u5404\u9879\u8d2b\u8840\u76f8\u5173\u7684\u8840\u5e38\u89c4\u53c2\u6570\u5728\u7ed9\u836f\u540e\u5747\u5f97\u5230\u663e\u8457\u6539\u5584\u3002\u5728\u8f83\u9ad8\u5242\u91cf\u7ec4\u6297\u8d2b\u8840\u6548\u679c\u4e0e\u4e34\u5e8a\u6807\u51c6\u7597\u6cd5EPO\u76f8\u5f53\uff1b\u5e76\u4e14\u5728\u4e2d\u5242\u91cf\u7ec4\u4e0eEPO\u8054\u7528\u540e\uff0c\u4e0e\u5355\u836f\u7ec4\u76f8\u6bd4\u53ef\u8fdb\u4e00\u6b65\u6539\u5584\u5927\u9f20\u7684\u4f53\u91cd\u4ee5\u53ca\u5404\u9879\u8d2b\u8840\u76f8\u5173\u7684\u8840\u5e38\u89c4\u53c2\u6570\uff0c\u81f3\u5b9e\u9a8c\u7ed3\u675f\u65f6\uff0c\u8054\u5408\u7ec4\u7684\u5927\u9f20\u5404\u9879\u8840\u5e38\u89c4\u53c2\u6570\u5747\u5df2\u6062\u590d\u81f3\u5bf9\u7167\u7ec4\u7684\u6c34\u5e73\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u9664APG-5918\u5916\uff0c\u5168\u7403\u5c42\u9762\u67094\u6b3e\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684EED\u6291\u5236\u5242\u3002\u5176\u4e2dFulcrum Therapeutics\u7684FTX-6058\u662f\u76ee\u524d\u552f\u4e00\u5904\u4e8e\u4e34\u5e8aI\u671f\u8bd5\u9a8c\u9636\u6bb5\u9488\u5bf9\u975e\u80bf\u7624\u9002\u5e94\u75c7\uff08\u5982\u9570\u72b6\u7ec6\u80de\u8d2b\u8840\u548c\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\uff09\u7684\u5c0f\u5206\u5b50EED\u6291\u5236\u5242\u3002 \u5e7f\u897f\u533b\u79d1\u5927\u5b66\u5730\u4e2d\u6d77\u8d2b\u8840\u9632\u6cbb\u7814\u7a76\u6240\u526f\u6240\u957f\u3001\u5730\u4e2d\u6d77\u8d2b\u8840\u9632\u6cbb\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u9648\u840d\u6559\u6388\u8868\u793a\uff1a&quot;\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u548c\u80be\u6027\u8d2b\u8840\u60a3\u8005\u90fd\u5b58\u5728\u5de8\u5927\u7684\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002\u4e9a\u76db\u533b\u836f\u5728\u7814\u7684APG-5918\u4ee5\u5168\u65b0\u7684\u4f5c\u7528\u673a\u5236\uff0c\u6709\u671b\u4e3a\u76f8\u5173\u8d2b\u8840\u7684\u6cbb\u7597\u63d0\u4f9b\u4e00\u4e2a\u5d2d\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u6211\u4eec\u671f\u5f85\u901a\u8fc7\u624e\u5b9e\u6709\u6548\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u6700\u7ec8\u80fd\u591f\u4e3a\u8d2b\u8840\u60a3\u8005\u63d0\u4f9b\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002&quot; \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a&quot;APG-5918\u662f\u56fd\u5185\u9996\u4e2aEED\u6291\u5236\u5242\uff0c\u6781\u5177\u4e34\u5e8a\u5f00\u53d1\u524d\u666f\u4e0e\u4ef7\u503c\uff0c\u5e76\u5728\u76f8\u5173\u7814\u7a76\u4e2d\u5448\u73b0\u2018Best-in-class&#8217;\u6f5c\u529b\u3002\u6211\u4eec\u5c06\u52a0\u901f\u63a8\u8fdbAPG-5918\u5728\u8d2b\u8840\u76f8\u5173\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u4e3a\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002&quot; \u53c2\u8003\u6587\u732e1.&nbsp;&nbsp;&nbsp; Shang, Peng et al. 2017, \u4e2d\u534e\u533b\u5b66\u4f1a\u533b\u5b66\u9057\u4f20\u5b66\u5206\u4f1a\u9057\u4f20\u75c5\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u64b0\u5199\u7ec4 20202.&nbsp;&nbsp;&nbsp; Thalassemia3.&nbsp;&nbsp;&nbsp; \u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u80be\u810f\u5185\u79d1\u533b\u5e08\u5206\u4f1a\u80be\u6027\u8d2b\u8840\u6307\u5357\u5de5\u4f5c\u7ec4&nbsp;2021 \u5173\u4e8e\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09 \u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002 \u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u6700\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67099\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216 MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5550\u591a\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7528\u4e8e\u6cbb\u7597\u8010\u836f\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\uff09\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9716\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c2\u9879FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u4ee5\u53ca2\u9879FDA\u513f\u7ae5\u7f55\u89c1\u75c5\u8d44\u683c\u8ba4\u8bc1\u3002\u516c\u53f8\u5148\u540e\u627f\u62c5\u591a\u9879\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff0c\u5176\u4e2d&quot;\u91cd\u5927\u65b0\u836f\u521b\u5236&quot;\u4e13\u98795\u9879\uff0c\u5305\u62ec1\u9879&quot;\u4f01\u4e1a\u521b\u65b0\u836f\u7269\u5b75\u5316\u57fa\u5730&quot;\u53ca4\u9879&quot;\u521b\u65b0\u836f\u7269\u7814\u53d1&quot;\uff0c\u53e6\u5916\u627f\u62c5&quot;\u91cd\u5927\u4f20\u67d3\u75c5\u9632\u6cbb&quot;\u4e13\u98791\u9879\u3002 \u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0eUNITY\u3001MD Anderson\u3001\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u4e1c\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u7b49\u9886\u5148\u7684\u751f\u7269\u6280\u672f\u53ca\u533b\u836f\u516c\u53f8\u3001\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u4e30\u5bcc\u7684\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u7ecf\u9a8c\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u540c\u65f6\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6807\u51c6\u6253\u9020\u540e\u671f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u53ca\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c&quot;\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42&quot;\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u58f0\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022112213260085922\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-85922","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/85922","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=85922"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/85922\/revisions"}],"predecessor-version":[{"id":85924,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/85922\/revisions\/85924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=85922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=85922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=85922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}