{"id":85864,"date":"2022-11-22T21:10:00","date_gmt":"2022-11-22T14:10:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022112221100085864"},"modified":"2022-11-23T22:16:31","modified_gmt":"2022-11-23T14:16:31","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%b0%86%e4%ba%8e%e7%be%8e%e5%9b%bd%e8%a1%80%e6%b6%b2%e5%ad%a6%e4%bc%9a%ef%bc%88ash%ef%bc%892022%e5%b9%b4%e4%bc%9a%e5%b0%b1alpine%e8%af%95%e9%aa%8c%e4%b8%ad","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022112221100085864","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5c06\u4e8e\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff092022\u5e74\u4f1a\u5c31ALPINE\u8bd5\u9a8c\u4e2d\u767e\u60a6\u6cfd\u00ae\u5bf9\u6bd4\u4ebf\u73c2\u00ae\u53d6\u5f97\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4f18\u6548\u6027\u7ed3\u679c\u8fdb\u884c\u6700\u65b0\u7a81\u7834\u6458\u8981\u7684\u53e3\u5934\u62a5\u544a"},"content":{"rendered":"

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\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n

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\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995 \u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u6709\u5173\u767e\u60a6\u6cfd®<\/sup>\u4e3a CLL \u60a3\u8005\u63d0\u4f9b\u4e34\u5e8a\u83b7\u76ca\u7684\u6f5c\u529b\u3001\u767e\u60a6\u6cfd®<\/sup>\u9488\u5bf9CLL\u6cbb\u7597\u7684\u672a\u6765\u5f00\u53d1\u3001\u836f\u653f\u7533\u62a5\u548c\u6279\u51c6\u3001\u5546\u4e1a\u5316\u548c\u5e02\u573a\u51c6\u5165\u3001\u767e\u60a6\u6cfd®<\/sup>\u6f5c\u5728\u7684\u5546\u4e1a\u673a\u4f1a\u3001\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728 "\u5173\u4e8e\u767e\u6d4e\u795e\u5dde"\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u62b1\u8d1f\u548c\u76ee\u6807\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u7684\u7ed3\u679c\u5b58\u5728\u5b9e\u8d28\u6027\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u653f\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u53ca\u5b9e\u73b0\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u75ab\u60c5\u5bf9\u767e\u6d4e\u795e\u5dde\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u3001\u5546\u4e1a\u5316\u8fd0\u8425\u3001\u751f\u4ea7\u4ee5\u53ca\u5176\u4ed6\u4e1a\u52a1\u5e26\u6765\u7684\u5f71\u54cd\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u62a5\u544a\u7684 10-Q \u8868\u683c\u4e2d"\u98ce\u9669\u56e0\u7d20"\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u7b49\u4fe1\u606f\u3002<\/p>\n

\u4ebf\u73c2®<\/sup>\u662f Pharmacyclics LLC \u548c Janssen Biotech, Inc.\u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n[i] Yao Y, Lin X, Li F, Jin J, Wang H. The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019. Biomed Eng Online. 2022 Jan 11;21(1):4. doi: 10.1186\/s12938-021-00973-6. PMID: 35016695; PMCID: PMC8753864.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c142022\u5e7411\u670822\u65e5 \/\u7f8e\u901a\u793e\/ — \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u5c06\u5728\u7f8e\u56fd\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c64\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u5c31\u5176ALPINE\u8bd5\u9a8c\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7ec8\u671f\u5206\u6790\u7ed3\u679c\u8fdb\u884c\u6700\u65b0\u7a81\u7834\u6458\u8981\u7684\u53e3\u5934\u62a5\u544a\u3002ALPINE\u662f\u4e00\u9879\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u767e\u60a6\u6cfd®\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u5bf9\u6bd4\u4ebf\u73c2®\uff08\u4f0a\u5e03\u66ff\u5c3c\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\uff08R\/R\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u7684\u6548\u679c\u3002\u8be5\u7ed3\u679c\u5c06\u4e8e\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f412\u670813\u65e5\u4e0a\u534810:15\u65f6\uff08\u5317\u4eac\u65f6\u95f412\u670814\u65e5\u51cc\u666800:15\uff09\u5728\u65b0\u5965\u5c14\u826fErnest N. Morial\u4f1a\u8bae\u4e2d\u5fc3E\u5385\u8fdb\u884c\u7684\u6700\u65b0\u7a81\u7834\u6458\u8981\u73af\u8282\u4e0a\u5c55\u793a\u3002 \u5728\u8be5\u8bd5\u9a8c\u6700\u7ec8PFS\u5206\u6790\u4e2d\uff0c\u7ecf\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08IRC\uff09\u548c\u7814\u7a76\u8005\u8bc4\u4f30\uff0c\u767e\u60a6\u6cfd®\u5bf9\u6bd4\u4ebf\u73c2®\u53d6\u5f97\u4e86\u4f18\u6548\u6027\u7ed3\u679c\uff08HR: 0.65 [95% CI\uff0c0.49-0.86]\uff0cP = 0.0024\uff09\u3002\u6839\u636eIRC\u548c\u7814\u7a76\u8005\u7684\u8bc4\u4f30\u7ed3\u679c\uff0c\u5728\u4e3b\u8981\u7684\u9884\u5b9a\u4e49\u4e9a\u7ec4\u4e2d\uff0c\u5305\u62ec\u5728\u4e0d\u540cIGHV\u72b6\u6001\u548c\u643a\u5e26del(17p)\/TP53\u7a81\u53d8\u7684\u60a3\u8005\u4e9a\u7ec4\u4e2d\uff0c\u767e\u60a6\u6cfd®\u5747\u663e\u793a\u51fa\u4e00\u81f4\u7684PFS\u4f18\u6548\u6027\u3002 \u767e\u6d4e\u795e\u5dde\u8840\u6db2\u5b66\u9996\u5e2d\u533b\u5b66\u5b98 Mehrdad Mobasher 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