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id=\"spanHghltb9f3\">\u610f\u5927\u5229\u3001\u82cf\u683c\u5170\u3001<\/span>\u897f\u73ed\u7259\u3001\u745e\u58eb\u548c\u8377\u5170\u83b7\u5f97\u4e86\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u6cbb\u7597WM\u7684\u62a5\u9500\uff0c\u5176\u4ed6\u6b27\u76df\u56fd\u5bb6\u4e5f\u6b63\u5728\u63a8\u8fdb\u5c06\u8be5\u836f\u7269\u7eb3\u5165\u5176\u62a5\u9500\u4f53\u7cfb\u7684\u8fdb\u7a0b\u4e2d\u3002<\/p>\n<p><b>\u5173\u4e8e\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08<\/b><b>CLL<\/b><b>\uff09<\/b><\/p>\n<p>CLL\u662f\u4e00\u79cd\u8fdb\u5c55\u7f13\u6162\u3001\u5371\u53ca\u751f\u547d\u4e14\u65e0\u6cd5\u6cbb\u6108\u7684\u6210\u4eba\u764c\u75c7\uff0c\u662f\u539f\u53d1\u4e8e\u9aa8\u9ad3\u7684\u5f02\u5e38\u767d\u8840\u75c5B\u6dcb\u5df4\u7ec6\u80de\uff08\u4e00\u79cd\u767d\u7ec6\u80de\uff09\u84c4\u79ef\u4e8e\u5916\u5468\u8840\u3001\u9aa8\u9ad3\u548c\u6dcb\u5df4\u7ec4\u7ec7\u7684\u4e00\u79cd\u6210\u719fB\u7ec6\u80de\u6076\u6027\u80bf\u7624<sup>[2],[3],[4]<\/sup>\u3002CLL\u662f\u767d\u8840\u75c5\u6700\u5e38\u89c1\u7684\u7c7b\u578b\u4e4b\u4e00\uff0c\u7ea6\u5360\u767d\u8840\u75c5\u65b0\u53d1\u75c5\u4f8b\u7684\u56db\u5206\u4e4b\u4e00<sup>[5]<\/sup>\u3002\u6b27\u6d32\u5730\u533a\u7684CLL\u53d1\u75c5\u7387\u9884\u4f30\u4e3a\u6bcf\u5e744.92\u4f8b\/10\u4e07\u4eba<sup>[6],[7]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u60a6\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><\/p>\n<p>\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u7814\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cdB\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u7684\u8bbe\u8ba1\u901a\u8fc7\u4f18\u5316\u751f\u7269\u5229\u7528\u5ea6\u3001\u534a\u8870\u671f\u548c\u9009\u62e9\u6027\uff0c\u5b9e\u73b0\u5bf9BTK\u86cb\u767d\u9776\u5411\u3001\u6301\u7eed\u7684\u6291\u5236\u3002\u51ed\u501f\u4e0e\u5176\u4ed6\u83b7\u6279BTK\u6291\u5236\u5242\u5b58\u5728\u5dee\u5f02\u5316\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u5df2\u88ab\u8bc1\u660e\u80fd\u5728\u591a\u4e2a\u75be\u75c5\u76f8\u5173\u7ec4\u7ec7\u4e2d\u6291\u5236\u6076\u6027B\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n<p>\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u5df2\u7ecf\u5f00\u5c55\u4e86\u5e7f\u6cdb\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\uff0c\u76ee\u524d\u5df2\u5728\u5168\u7403\u8d85\u8fc725\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u4e8635\u9879\u8bd5\u9a8c\uff0c\u603b\u5165\u7ec4\u53d7\u8bd5\u8005\u8d85\u8fc74,700\u4eba\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\u5df2\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u548c\u82f1\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u97e9\u56fd\u3001\u745e\u58eb\u548c\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u5728\u5185\u768458\u4e2a\u5e02\u573a\u83b7\u6279\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u9996\u521b\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u53d1\u548c\u533b\u5b66\u4e8b\u52a1\u56e2\u961f\u5df2\u6709\u8d85\u8fc73,500\u4eba\u4e14\u4ecd\u5728\u4e0d\u65ad\u58ee\u5927\u3002\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301100\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u5f00\u5c55\uff0c\u5df2\u62db\u52df\u53d7\u8bd5\u8005\u8d85\u8fc720,000\u4eba\u3002\u516c\u53f8\u5e7f\u6cdb\u7684\u7814\u53d1\u7ba1\u7ebf\u4e3b\u8981\u7531\u5185\u90e8\u56e2\u961f\u7275\u5934\uff0c\u652f\u6301\u8d85\u8fc745\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u516c\u53f8\u6df1\u8015\u4e8e\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u7684\u9776\u5411\u6cbb\u7597\u53ca\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5f00\u53d1\uff0c\u540c\u65f6\u4e13\u6ce8\u4e8e\u5355\u836f\u7597\u6cd5\u548c\u8054\u5408\u7597\u6cd5\u7684\u63a2\u7d22\u3002\u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u81ea\u4e3b\u7814\u53d1\u7684\u4e09\u6b3e\u836f\u7269\u5df2\u83b7\u6279\u4e0a\u5e02\uff1a\u767e\u60a6\u6cfd<b><sup>&reg;<\/sup><\/b>\uff08BTK \u6291\u5236\u5242\uff0c\u5df2\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u3001\u82f1\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u97e9\u56fd\u3001\u745e\u58eb\u53ca\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u83b7\u6279\u4e0a\u5e02\uff09\u3001\u767e\u6cfd\u5b89<b><sup>&reg;<\/sup><\/b>\uff08\u53ef\u6709\u6548\u907f\u514dFc-\u03b3\u53d7\u4f53\u7ed3\u5408\u7684\u6297PD-1\u6297\u4f53\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u53ca\u767e\u6c47\u6cfd<b><sup>&reg;<\/sup><\/b>\uff08PARP\u6291\u5236\u5242\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u8d1f\u8d23\u5bf9\u591a\u6b3e\u7531\u5b89\u8fdb\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u3001EUSA Pharma\u3001\u767e\u5965\u6cf0\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u7684\u5546\u4e1a\u5316\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ecMirati Therapeutics\u3001Seagen\u4ee5\u53caZymeworks\u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c\u66f4\u5927\u7a0b\u5ea6\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002<\/p>\n<p>2021\u5e741\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u5ba3\u5e03\u8fbe\u6210\u5408\u4f5c\uff0c\u6388\u4e88\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5171\u540c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6d4e\u795e\u5dde\u7684\u6297PD-1\u6297\u4f53\u836f\u7269\u767e\u6cfd\u5b89<b><sup>&reg;<\/sup><\/b>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff09\u7684\u6743\u5229\u3002\u57fa\u4e8e\u8fd9\u4e00\u5353\u6709\u6210\u6548\u7684\u5408\u4f5c\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u4e8e2021\u5e7412\u6708\u5ba3\u5e03\u4e86\u5173\u4e8e\u6b63\u57283\u671f\u5f00\u53d1\u7684TIGIT\u6291\u5236\u5242\u6b27\u53f8\u73c0\u5229\u5355\u6297\u8fbe\u6210\u9009\u62e9\u6743\u3001\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002\u8bfa\u534e\u548c\u767e\u6d4e\u795e\u5dde\u8fd8\u7b7e\u8ba2\u4e86\u4e00\u9879\u6218\u7565\u5546\u4e1a\u534f\u8bae\uff0c\u6839\u636e\u8be5\u534f\u8bae\uff0c\u767e\u6d4e\u795e\u5dde\u5c06\u5728\u4e2d\u56fd\u6307\u5b9a\u533a\u57df\u63a8\u5e7f5\u6b3e\u5df2\u83b7\u6279\u7684\u8bfa\u534e\u6297\u80bf\u7624\u836f\u7269\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u6297\u80bf\u7624\u836f\u7269\uff0c\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3001\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u901a\u8fc7\u5f3a\u5927\u7684\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5916\u90e8\u6218\u7565\u5408\u4f5c\uff0c\u6211\u4eec\u4e0d\u65ad\u52a0\u901f\u5f00\u53d1\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u66f4\u591a\u60a3\u8005\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u8fc79,000\u4eba\u7684\u56e2\u961f\uff0c\u5e76\u5728\u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c14\u8bbe\u7acb\u4e86\u4e3b\u8981\u529e\u4e8b\u5904\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.beigene.com.cn\/\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.beigene.com.cn<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u6709\u5173\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u4e3aCLL\u60a3\u8005\u63d0\u4f9b\u4e34\u5e8a\u83b7\u76ca\u7684\u6f5c\u529b\u3001\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u6b27\u76df\u548c\u5176\u4ed6\u5e02\u573a\u7684\u672a\u6765\u5f00\u53d1\u3001\u836f\u653f\u7533\u62a5\u548c\u6279\u51c6\u3001\u5546\u4e1a\u5316\u548c\u5e02\u573a\u51c6\u5165\u3001\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6f5c\u5728\u7684\u5546\u4e1a\u673a\u4f1a\u3001\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728&quot;\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66&quot;\u548c&quot;\u5173\u4e8e\u767e\u6d4e\u795e\u5dde&quot;\u6807\u9898\u4e0b\u63d0\u53ca\u7684\u8ba1\u5212\u3001\u627f\u8bfa\u3001\u62b1\u8d1f\u548c\u76ee\u6807\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u7684\u7ed3\u679c\u5b58\u5728\u5b9e\u8d28\u6027\u5dee\u5f02\u3002\u8fd9\u4e9b\u56e0\u7d20\u5305\u62ec\uff1a\u767e\u6d4e\u795e\u5dde\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u4e0a\u5e02\u5ba1\u6279\uff1b\u836f\u653f\u90e8\u95e8\u7684\u884c\u52a8\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u4e34\u5e8a\u8bd5\u9a8c\u7684\u542f\u52a8\u3001\u65f6\u95f4\u8868\u548c\u8fdb\u5c55\u4ee5\u53ca\u836f\u7269\u4e0a\u5e02\u5ba1\u6279\uff1b\u767e\u6d4e\u795e\u5dde\u7684\u4e0a\u5e02\u836f\u7269\u53ca\u5019\u9009\u836f\u7269\uff08\u5982\u80fd\u83b7\u6279\uff09\u83b7\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u83b7\u5f97\u548c\u7ef4\u62a4\u5bf9\u5176\u836f\u7269\u548c\u6280\u672f\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u767e\u6d4e\u795e\u5dde\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5176\u4ed6\u670d\u52a1\u7684\u60c5\u51b5\uff1b\u767e\u6d4e\u795e\u5dde\u53d6\u5f97\u76d1\u7ba1\u5ba1\u6279\u548c\u5546\u4e1a\u5316\u533b\u836f\u4ea7\u54c1\u7684\u6709\u9650\u7ecf\u9a8c\uff0c\u53ca\u5176\u83b7\u5f97\u8fdb\u4e00\u6b65\u7684\u8425\u8fd0\u8d44\u91d1\u4ee5\u5b8c\u6210\u5019\u9009\u836f\u7269\u5f00\u53d1\u3001\u5546\u4e1a\u5316\u53ca\u5b9e\u73b0\u5e76\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u75ab\u60c5\u5bf9\u767e\u6d4e\u795e\u5dde\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u3001\u5546\u4e1a\u5316\u8fd0\u8425\u3001\u751f\u4ea7\u4ee5\u53ca\u5176\u4ed6\u4e1a\u52a1\u5e26\u6765\u7684\u5f71\u54cd\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u62a5\u544a\u768410-Q\u8868\u683c\u4e2d&quot;\u98ce\u9669\u56e0\u7d20&quot;\u7ae0\u8282\u91cc\u66f4\u5168\u9762\u8ba8\u8bba\u7684\u5404\u7c7b\u98ce\u9669\uff1b\u4ee5\u53ca\u767e\u6d4e\u795e\u5dde\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u4ec5\u53ca\u4e8e\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6d4e\u795e\u5dde\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u8be5\u7b49\u4fe1\u606f\u3002<\/p>\n<p>*\u4ebf\u73c2<sup>&reg;<\/sup>\u662fPharmacyclics LLC\u548cJanssen Biotech, Inc.\u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><\/p>\n[1] BRUKINSA<b><sup>&reg;<\/sup><\/b>&nbsp;(zanubrutinib). Summary of product characteristics; 2022.<br \/>[2] National Cancer Institute. Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Leukemia \u2014Chronic Lymphocytic Leukemia (CLL). Accessed&nbsp;October 4,2021. &nbsp;<a href=\"https:\/\/seer.cancer.gov\/statfacts\/html\/clyl.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/seer.cancer.gov\/statfacts\/html\/clyl.html&nbsp;<\/a><br \/>[3] Aster JC, Freedman&nbsp;A. Non-Hodgkin&nbsp;lymphomas and chronic lymphocytic leukemias. In: Aster JC, Bunn HF (eds.). Pathophysiology of Blood Disorders. 2nd ed.&nbsp;McGraw-Hill Education; 2017:chap<br \/>[4] American Cancer Society. What is chronic lymphocytic leukemia? Updated&nbsp;May 10, 2018. Accessed&nbsp;December 6, 2020.&nbsp;<a href=\"https:\/\/www.cancer.org\/cancer\/chronic-lymphocytic-leukemia\/about\/what-is-cll.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.cancer.org\/cancer\/chronic-lymphocytic-leukemia\/about\/what-is-cll.html<\/a><br \/>[5] Yao Y, Lin X, Li F, Jin J, Wang H. The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019. Biomed Eng Online. 2022 Jan 11;21(1):4. doi: 10.1186\/s12938-021-00973-6. PMID: 35016695; PMCID: PMC8753864.<br \/>[6] Miranda-Filho, A., et al., Epidemiological patterns of leukaemia in 184 countries: a population-based study. The Lancet Haematology, 2018. 5(1): p. e14-e24.<br \/>[7] Sant, M., et al., Incidence of hematologic malignancies in&nbsp;Europe&nbsp;by morphologic subtype: results of the HAEMACARE project. 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*\u4ebf\u73c2&reg;\u662fPharmacyclics LLC\u548cJanssen Biotech, Inc.\u7684\u6ce8\u518c\u5546\u6807\u3002 \u53c2\u8003\u6587\u732e [1] BRUKINSA&reg;&nbsp;(zanubrutinib). Summary of product characteristics;&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022111719000085373\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-85373","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/85373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=85373"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/85373\/revisions"}],"predecessor-version":[{"id":85374,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/85373\/revisions\/85374"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=85373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=85373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=85373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}