{"id":84174,"date":"2022-11-07T19:18:00","date_gmt":"2022-11-07T12:18:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022110719180084174"},"modified":"2022-11-07T23:21:09","modified_gmt":"2022-11-07T15:21:09","slug":"%e5%85%b7%e6%9c%89%e9%87%8c%e7%a8%8b%e7%a2%91%e6%84%8f%e4%b9%89%e7%9a%84empa-kidney%e8%af%95%e9%aa%8c%e8%a1%a8%e6%98%8e%ef%bc%8c%e5%9c%a8%e6%85%a2%e6%80%a7%e8%82%be%e8%84%8f%e7%97%85%e6%82%a3%e8%80%85","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022110719180084174","title":{"rendered":"\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u7684EMPA-KIDNEY\u8bd5\u9a8c\u8868\u660e\uff0c\u5728\u6162\u6027\u80be\u810f\u75c5\u60a3\u8005\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u6069\u683c\u5217\u51c0\u663e\u8457\u964d\u4f4e\u60a3\u8005\u80be\u810f\u75be\u75c5\u8fdb\u5c55\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7684\u98ce\u9669\u8fbe28%"},"content":{"rendered":"<ul type=\"disc\">\n<li>EMPA-KIDNEY \u662f\u8fc4\u4eca\u4e3a\u6b62\u9488\u5bf9\u6162\u6027\u80be\u75c5\u7684\u6700\u5927\u548c\u6700\u5e7f\u6cdb\u7684 SGLT2 \u6291\u5236\u5242\u8bd5\u9a8c\uff0c\u4e3a\u4e34\u5e8a\u4e2d\u5e38\u89c1\u7684\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u8bc1\u636e<sup>[1],[2]<\/sup><\/li>\n<li>III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8fd8\u8868\u660e\uff0c\u56e0\u4efb\u4f55\u539f\u56e0\u800c\u4f4f\u9662\u6cbb\u7597\u7684\u98ce\u9669\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u964d\u4f4e\uff0814\uff05\uff09<sup>[1]<\/sup><sup>,[<\/sup><sup>2]<\/sup>\uff0c\u6709\u671b\u7f13\u89e3\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u5e76\u51cf\u8f7b\u533b\u7597\u8d1f\u62c5<sup>[3]<\/sup><\/li>\n<\/ul>\n<p id=\"temp_ReleaseStart\"><span class=\"legendSpanClass\">\u82f1\u56fd\u725b\u6d25\u3001\u5fb7\u56fd\u6bb7\u683c\u7ff0\u3001\u7f8e\u56fd\u5370\u7b2c\u5b89\u7eb3\u6ce2\u5229\u65af\u548c\u91cc\u5947\u83f2\u5c14\u5fb7<\/span><span class=\"legendSpanClass\">2022\u5e7411\u67087\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; EMPA-KIDNEY III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\uff0c\u5176\u5bf9\u60a3\u6709\u6162\u6027\u80be\u75c5 (CKD) \u7684\u6210\u5e74\u60a3\u8005\u6709\u80be\u810f\u548c\u5fc3\u8840\u7ba1\u65b9\u9762\u7684\u663e\u8457\u76ca\u5904\uff0c\u8fbe\u5230\u4e86\u5176\u4e3b\u8981\u7ec8\u70b9<sup>[1]<\/sup><sup>,[<\/sup><sup>2]<\/sup>\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u670d\u7528\u6069\u683c\u5217\u51c0\u540e\uff0c\u80be\u810f\u75be\u75c5\u8fdb\u5c55\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7684\u98ce\u9669\u663e\u8457\u964d\u4f4e28%\uff08HR\uff1b0.72\uff1b95% CI 0.64 &#8211; 0.82\uff1bP&lt;0.000001\uff09<sup>[1]<\/sup><sup>,[<\/sup><sup>2]<\/sup>\u3002\u725b\u6d25\u5927\u5b66\u533b\u5b66\u7814\u7a76\u59d4\u5458\u4f1a\u4eba\u53e3\u5065\u5eb7\u7814\u7a76\u5ba4 (MRC PHRU) \u5728\u7f8e\u56fd\u80be\u810f\u75c5\u5b66\u4f1a (ASN) \u7684 2022 \u80be\u810f\u5468\u671f\u95f4\u516c\u5e03\u4e86\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u5ba4\u8bbe\u8ba1\u3001\u5b9e\u65bd\u548c\u5206\u6790\u4e86EMPA-KIDNEY\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u5f97\u5230\u4e86\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548c\u793c\u6765\u516c\u53f8\uff08NYSE:LLY\uff09\u7684\u8d44\u91d1\u652f\u6301\u3002 \u8be5\u7ed3\u679c\u4e5f\u540c\u6b65\u53d1\u8868\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a<sup>[2]<\/sup>\u3002<\/p>\n<p class=\"prntaj\">EMPA-KIDNEY\u7814\u7a76\u9996\u6b21\u8bc1\u660e\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u6069\u683c\u5217\u51c0\u53ef\u4f7fCKD\u60a3\u8005\u5168\u56e0\u4f4f\u9662\u7684\u53d1\u751f\u98ce\u9669\u663e\u8457\u964d\u4f4e\uff0814%\uff09\uff08HR\uff1b0.86\uff1b95%CI 0.78 &#8211; 0.95\uff1bP=0.0025\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u9884\u5148\u89c4\u5b9a\u7684\u786e\u8bc1\u6027\u7ec8\u70b9<sup>[1]<\/sup><sup>,[<\/sup><sup>2]<\/sup>\u3002CKD\u662f\u5bfc\u81f4\u5168\u7403\u60a3\u8005\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5e76\u4f7f\u60a3\u8005\u7684\u4f4f\u9662\u98ce\u9669\u589e\u52a0\u4e00\u500d<sup>[4],[5]<\/sup>\u3002\u5728\u7f8e\u56fd\uff0cCKD\u60a3\u8005\u7684\u4f4f\u9662\u8d39\u7528\u5360\u603b\u533b\u7597\u8d39\u7528\u768435%-55%<sup>[6]<\/sup>\u3002&nbsp;<\/p>\n<p class=\"prntaj\">\u8be5\u8bd5\u9a8c\u603b\u4f53\u5b89\u5168\u6027\u6570\u636e\u4e0e\u4e4b\u524d\u7684\u7814\u7a76\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\uff0c\u8bc1\u5b9e\u4e86\u6069\u683c\u5217\u51c0\u5df2\u786e\u7acb\u7684\u5b89\u5168\u6027\u3002<\/p>\n<p class=\"prntaj\">\u201c\u6211\u4eec\u8feb\u5207\u5730\u9700\u8981\u7ecf\u8bc1\u5b9e\u53ef\u4ee5\u5ef6\u7f13CKD\u8fdb\u5c55\u81f3\u900f\u6790\u6216\u79fb\u690d\u7684\u65b0\u7597\u6cd5\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u4f34\u6216\u4e0d\u4f34\u7cd6\u5c3f\u75c5\u7684\u6210\u5e74\u60a3\u8005\uff0c\u65e0\u8bba\u5176\u80be\u529f\u80fd\u5982\u4f55\uff0c\u6069\u683c\u5217\u51c0\u5747\u53ef\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\u3002\u201d\u725b\u6d25\u4eba\u53e3\u5065\u5eb7\u8bca\u6240\u79d1\u5b66\u5bb6\u3001\u540d\u8a89\u987e\u95ee\u80be\u75c5\u5b66\u5bb6\u3001EMPA-KIDNEY\u8054\u5408\u9996\u5e2d\u7814\u7a76\u5458\u3001\u526f\u6559\u6388William Herrington\u8bf4\u9053\u3002\u201c\u901a\u8fc7\u964d\u4f4e\u80be\u810f\u75be\u75c5\u8fdb\u5c55\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7684\u98ce\u9669\uff0c\u6069\u683c\u5217\u51c0\u53ef\u80fd\u5bf9\u5168\u7403\u533b\u7597\u7cfb\u7edf\u4ea7\u751f\u79ef\u6781\u5f71\u54cd\u3002\u201d<\/p>\n<p class=\"prntaj\">\u201cEMPA-KIDNEY\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u5305\u542b\u4e86\u6bd4\u4ee5\u5f80\u66f4\u5e7f\u6cdb\u7684\u60a3\u8005\u7fa4\u3002\u201d\u8054\u5408\u9996\u5e2d\u7814\u7a76\u5458Richard Haynes\u6559\u6388\u8bf4\u3002\u201c\u4e4b\u524d\u7684SGLT2\u6291\u5236\u5242\u8bd5\u9a8c\u66f4\u4fa7\u91cd\u4e8e\u7279\u5b9a\u7684CKD\u60a3\u8005\uff0c\u4f8b\u5982\u5408\u5e76\u7cd6\u5c3f\u75c5\u6216\u86cb\u767d\u5c3f\u8f83\u9ad8\u7684\u60a3\u8005\u3002\u4eca\u5929\u5728\u5e7f\u6cdbCKD\u60a3\u8005\u4e2d\u7684\u79ef\u6781\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u836f\u7269\u6709\u671b\u6539\u5584\u66f4\u591aCKD\u60a3\u8005\u7684\u6cbb\u7597\u524d\u666f\u5e76\u907f\u514d\u60a3\u8005\u8fdb\u5c55\u81f3\u900f\u6790\u3002\u201d<\/p>\n<p class=\"prntaj\">EMPA-KIDNEY\u662f\u8fc4\u4eca\u4e3a\u6b62\u6700\u5927\u548c\u6700\u5e7f\u6cdb\u7684SGLT-2i\u4e13\u6ce8\u4e8eCKD\u9886\u57df\u7684\u8bd5\u9a8c<sup>[7]<\/sup>\u3002\u8fd9\u9879\u7814\u7a76\u5305\u62ec6609\u591a\u540d\u53c2\u4e0e\u8005\uff0c\u6d89\u53ca\u5e7f\u6cdb\u7684\u6f5c\u5728\u75c5\u56e0\uff0c\u5176\u4e2d\u8bb8\u591a\u60a3\u8005\u5408\u5e76\u5fc3\u8840\u7ba1\u3001\u80be\u810f\u6216\u4ee3\u8c22\u75be\u75c5\u3002\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u4e0d\u540cCKD\u4e25\u91cd\u7a0b\u5ea6\u60a3\u8005\u7684\u80be\u810f\u548c\u5fc3\u8840\u7ba1\u7ed3\u5c40<sup>[8]<\/sup>\u3002<\/p>\n<p class=\"prntaj\">\u201c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548c\u793c\u6765\u7684\u7cd6\u5c3f\u75c5\u8054\u76df\u5bf9EMPA-KIDNEY\u518d\u6b21\u4e3a\u6b27\u5510\u9759\u53d6\u5f97\u91cc\u7a0b\u7891\u5f0f\u7684\u6210\u679c\u611f\u5230\u65e0\u6bd4\u81ea\u8c6a\uff0c\u201d\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4eba\u836f\u4e1a\u52a1\u8d1f\u8d23\u4eba\u3001\u8463\u4e8b\u4f1a\u6210\u5458Carinne Brouillon\u8bf4\u9053\u3002\u201cASN\u516c\u5e03\u7684\u6570\u636e\u4e3a\u6211\u4eec\u7684\u4e34\u5e8a\u9879\u76ee\u63d0\u4f9b\u4e86\u5927\u91cf\u8bc1\u636e\uff0c\u8be5\u9879\u76ee\u5305\u62ec\u8d85\u8fc770\u4e07\u540d\u5fc3\u8840\u7ba1\u3001\u80be\u810f\u548c\u4ee3\u8c22\u75be\u75c5\u7684\u6210\u5e74\u60a3\u8005\u3002EMPA- KIDNEY\u52a0\u5f3a\u4e86\u6069\u683c\u5217\u51c0\u5728\u6539\u53d8\u8fd9\u4e9b\u76f8\u4e92\u5173\u8054\u7684\u75be\u75c5\u7684\u7ba1\u7406\u65b9\u5f0f\u65b9\u9762\u7684\u91cd\u8981\u4f5c\u7528\u3002\u201d<\/p>\n<p class=\"prntaj\">\u56e0\u5fc3\u529b\u8870\u7aed\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u6216\u5168\u56e0\u6b7b\u4ea1\u4f4f\u9662\u7684\u5176\u4ed6\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u7684\u51cf\u5c11\u6ca1\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4f46\u5176\u68c0\u9a8c\u80fd\u529b\u53d7\u5230\u89c2\u5bdf\u5230\u7684\u4e8b\u4ef6\u6570\u91cf\u7684\u9650\u5236\u3002\u8fd9\u4e9b\u7ec8\u70b9\u4e8b\u4ef6\u98ce\u9669\u7684\u964d\u4f4e\u4e0e\u5176\u4ed6\u8bd5\u9a8c\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u76f8\u5e94\u7ed3\u679c\u5747\u4e00\u81f4\u3002<\/p>\n<p class=\"prntaj\">\u201cEMPA-KIDNEY \u8bd5\u9a8c\u7ed3\u679c\u5c06\u53d7\u5230 CKD \u60a3\u8005\u548c\u533b\u5b66\u754c\u7684\u6b22\u8fce\u3002\u6211\u4eec\u4e5f\u5bf9\u6cbb\u7597\u4ec5\u4e24\u5e74\u540e\u5373\u89c2\u5bdf\u5230\u4f4f\u9662\u98ce\u9669\u7684\u663e\u8457\u964d\u4f4e\u800c\u5907\u53d7\u9f13\u821e\uff0c\u56e0\u4e3a\u8fd9\u4e00\u53d1\u73b0\u4e0e\u4e4b\u524d\u6069\u683c\u5217\u51c0\u5fc3\u8840\u7ba1\u7ed3\u5c40\u8bd5\u9a8c\u4e2d\u7684\u663e\u8457\u964d\u4f4e\u4e00\u81f4\uff0c\u201d\u793c\u6765\u516c\u53f8\u4ea7\u54c1\u5f00\u53d1\u526f\u603b\u88c1\u3001\u533b\u5b66\u535a\u58ebJeff Emmick\u8bf4\u9053\u3002\u201c\u8054\u76df\u671f\u5f85\u5728\u9002\u5f53\u65f6\u5019\u4e0e\u5168\u7403\u5404\u5730\u7684\u76d1\u7ba1\u673a\u6784\u8ba8\u8bba\u6069\u683c\u5217\u51c0\u7684 CKD\u65b0\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u8bb8\u53ef\u8ba1\u5212\u3002\u201d<\/p>\n<p 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