{"id":83193,"date":"2022-11-03T20:10:00","date_gmt":"2022-11-03T13:10:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022110320100083193"},"modified":"2022-11-03T22:38:20","modified_gmt":"2022-11-03T14:38:20","slug":"%e4%ba%98%e5%96%9c%e7%94%9f%e7%89%a9%e5%b0%86%e5%9c%a8%e7%ac%ac64%e5%b1%8aash%e5%b9%b4%e4%bc%9a%e4%b8%8a%e9%a6%96%e6%ac%a1%e5%85%ac%e5%b8%83fastcar-t-gc012f%e9%92%88%e5%af%b9%e5%a4%9a%e5%8f%91","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022110320100083193","title":{"rendered":"\u4e98\u559c\u751f\u7269\u5c06\u5728\u7b2c64\u5c4aASH\u5e74\u4f1a\u4e0a\u9996\u6b21\u516c\u5e03FasTCAR-T GC012F\u9488\u5bf9\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u521d\u8bca\u60a3\u8005\u7684\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Logo-437.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"prntac\"><i>BCMA\/CD19<\/i><i>\u53cc\u9776\u70b9<\/i><i>FasTCAR-T GC012F<\/i><i>\u5728\u9488\u5bf9<\/i><i>13<\/i><i>\u540d\u60a3\u8005\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c<\/i><i>\u5c55\u793a\u51fa<\/i><i>100% ORR<\/i><i>\u548c<\/i><i>100% MRD<\/i><i>\u9634\u6027\u7684\u7597\u6548<\/i><\/p>\n<p><p><span class=\"legendSpanClass\">\u4e2d\u56fd\u6c5f\u82cf\u82cf\u5dde\u3001\u4e0a\u6d77\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u8fed\u6208<\/span><span class=\"legendSpanClass\">2022\u5e7411\u67083\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>GC012F\u662f\u4e00\u6b3e\u53cc\u9776\u70b9\u81ea\u4f53CAR-T\u5019\u9009\u4ea7\u54c1\uff0c\u80fd\u540c\u65f6\u9776\u5411B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u548cCD19\u4e24\u4e2a\u6cbb\u7597\u9776\u70b9\u3002\u8be5\u5019\u9009\u4ea7\u54c1\u4f9d\u6258\u4e8e\u516c\u53f8\u4e13\u6709\u7684FasTCAR\u5e73\u53f0\uff0c\u5177\u5907&quot;\u6b21\u65e5\u5b8c\u6210\u751f\u4ea7&quot;\u7684\u4f18\u52bf\u3002<\/p>\n<p>\u622a\u81f32022\u5e747\u670825\u65e5\u4f1a\u8bae\u6458\u8981\u6570\u636e\u622a\u6b62\u65e5\uff0c13\u4f4d\u7b26\u5408\u79fb\u690d\u6761\u4ef6\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u521d\u8bca\u60a3\u8005\u5df2\u63a5\u53d7GC012F\u7ed9\u836f\u3002\u6240\u6709\u60a3\u8005\u5747\u5177\u6709\u4e00\u4e2a\u6216\u591a\u4e2a\u9ad8\u5371\u7279\u5f81\u3002\u5728\u8fdb\u884c\u4e86\u73af\u78f7\u9170\u80fa\u548c\u6c1f\u8fbe\u62c9\u6ee8\u7684\u5316\u7597\u9884\u5904\u7406\u540e\uff0c\u5165\u7ec4\u60a3\u8005\u5206\u522b\u63a5\u53d7\u4e86GC012F\u4e09\u79cd\u4e0d\u540c\u5242\u91cf\u6c34\u5e73\u7684\u5355\u6b21\u8f93\u6ce8\uff1a1&#215;10<sup>5<\/sup>\u7ec6\u80de\/\u5343\u514b\u4f53\u91cd\uff08\u7b2c1\u5242\u91cf\u7ec4\uff09\u30012&#215;10<sup>5<\/sup>\u7ec6\u80de\/\u5343\u514b\u4f53\u91cd\uff08\u7b2c2\u5242\u91cf\u7ec4\uff09\u30013&#215;10<sup>5<\/sup>\u7ec6\u80de\/\u5343\u514b\u4f53\u91cd\uff08\u7b2c3\u5242\u91cf\u7ec4\uff09\u3002<\/p>\n<p>\u672c\u4e34\u5e8a\u8bd5\u9a8c\u5c1a\u5728\u8fdb\u884c\u4e2d\u3002\u622a\u81f3ASH\u6458\u8981\u6570\u636e\u622a\u6b62\u65e5\uff0c13\u540d\u7597\u6548\u53ef\u8bc4\u4f30\u60a3\u8005\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a5.3\u4e2a\u6708\uff08\u8303\u56f4\uff1a2.3-12.5\u4e2a\u6708\uff09\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u603b\u4f53\u5e94\u7b54\u7387\u9ad8\u8fbe100%<\/li>\n<li>69%\u7684\u60a3\u8005\u53d6\u5f97\u4e86\u4e25\u683c\u610f\u4e49\u4e0a\u7684\u5b8c\u5168\u7f13\u89e3\uff08sCR\uff09\uff1b\u76ee\u524d\uff0c\u8be5\u7814\u7a76\u4ecd\u5728\u5bf9\u60a3\u8005\u8fdb\u884c\u6301\u7eed\u968f\u8bbf\uff0c\u4ee5\u8bc4\u4f30\u4e0d\u65ad\u52a0\u6df1\u7684\u53cd\u5e94<\/li>\n<li>\u6240\u6709\u60a3\u8005\u5747\u8fbe\u5230\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u9634\u6027<\/li>\n<li>\u5728\u7b2c1\u4e2a\u6708\u53ca\u7b2c6\u4e2a\u6708\uff0c\u901a\u8fc7EuroFlow\u65b9\u6cd5\u8fdb\u884cMRD\u7684\u9636\u6bb5\u6027\u68c0\u6d4b\u8bc4\u4f30\uff0c\u6240\u6709\u53ef\u8bc4\u4f30\u60a3\u8005\u5728\u4e24\u4e2a\u65f6\u95f4\u70b9\u5747\u8fbe\u5230MRD\u9634\u6027<\/li>\n<li>\u6240\u6709\u60a3\u8005\u4f53\u5185\u5747\u89c2\u5bdf\u5230CAR-T\u7ec6\u80de\u7684\u5f3a\u52b2\u6269\u589e<\/li>\n<\/ul>\n<p>\u5e76\u4e14\uff0c\u4e34\u5e8a\u6570\u636e\u521d\u6b65\u663e\u793a\u4e86\u4f18\u5f02\u7684\u5b89\u5168\u6027\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u4ec523%\uff083\/13\uff09\u7684\u60a3\u8005\u53d1\u751f\u4e861-2\u7ea7\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09<\/li>\n<li>\u672a\u51fa\u73b03\u7ea7\u53ca\u4ee5\u4e0a\u7684CRS\uff0c\u4e14\u5e76\u672a\u89c2\u5bdf\u5230\u4efb\u4f55\u7ea7\u522b\u7684\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u76f8\u5173\u795e\u7ecf\u6bd2\u6027\u7efc\u5408\u5f81\uff08ICANS\uff09\u7684\u53d1\u751f<\/li>\n<\/ul>\n<p>\u53e3\u5934\u62a5\u544a\u8be6\u60c5\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>\u6458\u8981\u6807\u9898\uff1a<\/b>BCMA\/CD19\u53cc\u9776\u70b9FasTCAR-T\u7ec6\u80de\u7597\u6cd5\uff08GC012F\uff09\u4f5c\u4e3a\u7b26\u5408\u79fb\u690d\u6761\u4ef6\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9ad8\u5371\u521d\u8bca\u60a3\u8005\u4e00\u7ebf\u7597\u6cd5\u76841\u671f\u3001\u5f00\u653e\u6027\u5355\u81c2\u4e34\u5e8a\u7814\u7a76<br \/><b>Abstract title: <\/b><span>Phase I Open-Label Single-Arm Study of BCMA\/CD19 Dual-Targeting FasTCAR-T Cells (GC012F) As First-Line Therapy for Transplant-Eligible Newly Diagnosed High-Risk Multiple Myeloma<br \/><\/span>&nbsp;<\/li>\n<li><b>\u6458\u8981\u7f16\u53f7\uff1a<\/b> 162295<br \/><b>Abstract ID: <\/b><span>162295\n<p><\/span><\/li>\n<li><b>\u73af\u8282\u540d\u79f0\uff1a<\/b><span>704. \u7ec6\u80de\u514d\u75ab\u6cbb\u7597\uff1a\u65e9\u671f\u53ca\u63a2\u7d22\u6027\u7597\u6cd5\uff1aCAR-T\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u540c\u79cd\u5f02\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u7684T\u7ec6\u80de\u7597\u6cd5<br \/><\/span><b>Session Name: <\/b><span>704. Cellular Immunotherapies: Early Phase and Investigational Therapies: CAR T in Multiple Myeloma and T-cell Therapies After Allo-HCT\n<p><\/span><\/li>\n<li><b>\u73af\u8282\u65f6\u95f4\uff1a<\/b><span>2022\u5e7412\u670810\u65e5\uff08\u661f\u671f\u516d\uff09\uff0c\u4e0b\u53484:00-5:30\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/><\/span><b>Session Date: <\/b><span><span class=\"xn-chron\">Saturday, Dec. 10, 2022<\/span> from <span class=\"xn-chron\">4-5:30 p.m. CT<\/span>\n<p><\/span><\/li>\n<li><b>\u62a5\u544a\u65f6\u95f4\uff1a<\/b><span>\u4e0b\u53485:15\uff08\u7f8e\u56fd\u4e2d\u90e8\u65f6\u95f4\uff09<br \/><\/span><b>Presentation Time:<\/b><span> <span class=\"xn-chron\">5:15 p.m. CT<\/span><\/span><span>\n<p><\/span><\/li>\n<li><b>\u62a5\u544a\u5730\u70b9\uff1a<\/b><span>Ernest N. Morial\u4f1a\u8bae\u4e2d\u5fc3, Great Hall A\/D<br \/><\/span><b>Location: <\/b><span>Ernest N. 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id=\"spanHghlt93fa\">\u8bf7\u8bbf\u95eewww.gracellbio.com\/\u5173\u6ce8\u9886\u82f1\u8d26\u53f7@GracellBio<\/span>\u3002<\/p>\n<p><b>\u5173\u4e8e\u524d\u77bb\u6027\u9648\u8ff0\u7684\u8b66\u6212\u6027\u58f0\u660e<\/b><\/p>\n<p>\u8be5\u65b0\u95fb\u7a3f\u4e2d\u9488\u5bf9\u672a\u6765\u9884\u671f\u3001\u8ba1\u5212\u3001\u524d\u666f\u4ee5\u53ca\u5176\u4ed6\u975e\u5386\u53f2\u4e8b\u5b9e\u7684\u58f0\u660e\u53ef\u80fd\u5305\u542b\u6839\u636e\u300a1995 \u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4e0b\u5b9a\u4e49\u7684&quot;\u524d\u77bb\u6027\u58f0\u660e&quot;\u3002\u8fd9\u4e9b\u58f0\u660e\u53ef\u80fd\u4f46\u4e0d\u4e00\u5b9a\u5305\u542b\u4e0b\u5217\u8bcd\u6c47\u4ee5\u53ca\u76f8\u5bf9\u5e94\u7684\u5426\u5b9a\u5f62\u5f0f\u6216\u76f8\u4f3c\u7684\u8bcd\u6c47\uff1a\u76ee\u7684\u4e3a\u3001\u9884\u671f\u3001\u76f8\u4fe1\u3001 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\/><\/b><b><span class=\"xn-person\">Marvin Tang<\/span><br \/><\/b><a href=\"mailto:marvin.tang@gracellbio.com\" target=\"_blank\" rel=\"nofollow noopener\">marvin.tang@gracellbio.com<\/a><\/p>\n<p><b>\u6295\u8d44\u8005\u8054\u7cfb\u4eba<br \/><\/b><b><span class=\"xn-person\">Gracie Tong<\/span><br \/><\/b><a href=\"mailto:gracie.tong@gracellbio.com\" target=\"_blank\" rel=\"nofollow noopener\">gracie.tong@gracellbio.com<\/a><\/p>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>BCMA\/CD19\u53cc\u9776\u70b9FasTCAR-T GC012F\u5728\u9488\u5bf913\u540d\u60a3\u8005\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5c55\u793a\u51fa100% ORR\u548c100% MRD\u9634\u6027\u7684\u7597\u6548 \u4e2d\u56fd\u6c5f\u82cf\u82cf\u5dde\u3001\u4e0a\u6d77\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u8fed\u62082022\u5e7411\u67083\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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