{"id":83107,"date":"2022-11-03T12:03:00","date_gmt":"2022-11-03T05:03:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022110312030083107"},"modified":"2022-11-03T22:13:07","modified_gmt":"2022-11-03T14:13:07","slug":"%e7%bb%bf%e5%8f%b6%e5%88%b6%e8%8d%af%e6%8a%97%e6%8a%91%e9%83%811%e7%b1%bb%e5%88%9b%e6%96%b0%e8%8d%af%e8%8b%a5%e6%ac%a3%e6%9e%97%e8%8e%b7%e6%89%b9%e4%b8%8a%e5%b8%82","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022110312030083107","title":{"rendered":"\u7eff\u53f6\u5236\u836f\u6297\u6291\u90c11\u7c7b\u521b\u65b0\u836f\u82e5\u6b23\u6797\u00ae\u83b7\u6279\u4e0a\u5e02"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2022\u5e7411\u67083\u65e5<\/span> <span>\/\u7f8e\u901a\u793e\/ 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&reg;<\/sup>\u7684\u4f5c\u7528\u673a\u5236\u7814\u7a76\u7ed3\u679c\u5df2\u5728\u300aFrontiers in Pharmacology\u300b\u4e0a\u53d1\u8868<sup>[10,11]<\/sup>\uff0cII\u671f\u4e34\u5e8a\u7ed3\u679c\u5df2\u5728\u300aInternational Journal of Neuropsychopharmacology\u300b\u4e0a\u53d1\u8868<sup>[12]<\/sup>\u3001\u5e76\u5728\u4e2d\u534e\u533b\u5b66\u4f1a\u7b2c\u5341\u4e5d\u6b21\u5168\u56fd\u7cbe\u795e\u533b\u5b66\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u5e03\uff0cIII\u671f\u4e34\u5e8a\u7ed3\u679c\u57282022\u5e74\u7f8e\u56fd\u7cbe\u795e\u75c5\u5b66\u534f\u4f1a\uff08American Psychiatric Association, APA\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u3002\u4e34\u5e8a\u524d\u4f5c\u7528\u673a\u5236\u7814\u7a76\u8bc1\u660e\u5176\u4e3a5-\u7f9f\u8272\u80fa\uff085-HT\uff09\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08NE\uff09\u548c\u591a\u5df4\u80fa\uff08DA\uff09\u4e09\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNDRI\uff09\u30025-HT\u3001NE\u548cDA\u80fd\u795e\u7ecf\u7cfb\u7edf\u5728\u6291\u90c1\u75c7\u7684\u53d1\u75c5\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272<sup>[13]<\/sup>\u3002\u4e0e\u73b0\u6709\u7684\u9009\u62e9\u60275-HT\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SSRI\uff09\u30015-HT\/NE\u53cc\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNRI\uff09\u76f8\u6bd4\uff0cSNDRI\u589e\u52a0\u4e86\u5bf9DA\u7684\u5e72\u9884\uff0c\u53ef\u5b9e\u73b0\u6cbb\u7597\u4f5c\u7528\u76f8\u4e92\u534f\u540c\uff0c\u66f4\u5168\u9762\u5730\u7f13\u89e3\u6291\u90c1\u75c7\u60a3\u8005\u4e0d\u540c\u7ef4\u5ea6\u7684\u75c7\u72b6\uff0c\u540c\u65f6\u62ee\u62975-HT\u6c34\u5e73\u589e\u52a0\u5e26\u6765\u7684DA\u80fd\u4e0b\u964d\u6240\u5f15\u8d77\u7684\u526f\u4f5c\u7528<sup>[14]<\/sup>\u3002<\/p>\n<p>\u82e5\u6b23\u6797<sup>&reg;<\/sup>\u6b64\u6b21\u83b7\u6279\u57fa\u4e8e\u5176\u5728\u4e2d\u56fd\u5b8c\u6210\u7684\u516d\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2dIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u8bc4\u4f30\u8be5\u836f\u7269\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8be5\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u82e5\u6b23\u6797<sup>&reg;<\/sup>\u6cbb\u75978\u5468\u672b\u7684\u8499\u54e5\u9a6c\u5229-\u827e\u65af\u4f2f\u683c\u6291\u90c1\u91cf\u8868\uff08MADRS\uff09\u603b\u5206\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u300117\u9879\u6c49\u5bc6\u5c14\u987f\u6291\u90c1\u91cf\u8868\uff08HAM-D17\uff09\u603b\u5206\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u3001MADRS\u6709\u6548\u7387\u53ca\u7f13\u89e3\u7387\u3001HAM-D17\u6709\u6548\u7387\u548c\u7f13\u89e3\u7387\u3001\u6c49\u5bc6\u5c14\u987f\u7126\u8651\u91cf\u8868\uff08HAM-A\uff09\u603b\u5206\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u5747\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u7279\u522b\u5728\u6539\u5584\u5feb\u611f\u7f3a\u5931\u3001\u963b\u6ede\u3001\u8ba4\u77e5\u969c\u788d\u4ee5\u53ca\u75b2\u52b3\u7b49\u65b9\u9762\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5177\u7edf\u8ba1\u5b66\u5dee\u5f02\uff0c\u4e0e\u4f20\u7edf\u6297\u6291\u90c1\u836f\u7269\u76f8\u6bd4\u4f18\u52bf\u660e\u663e\uff1b\u82e5\u6b23\u6797<sup>&reg;<\/sup>\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e0d\u5f15\u53d1\u55dc\u7761\uff0c\u4e0d\u5f71\u54cd\u6027\u529f\u80fd\u3001\u4f53\u91cd\u548c\u8102\u4ee3\u8c22\u3002<\/p>\n<p><b>\u82e5\u6b23\u6797<\/b><b><sup>&reg;<\/sup><\/b><b>\u7814\u53d1\u9879\u76ee\u8d1f\u8d23\u4eba\u3001\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u975e\u4e34\u5e8a\u7814\u7a76\u90e8\u526f\u603b\u88c1\u3001\u65b0\u836f\u53d1\u73b0\u7814\u7a76\u90e8\u8d1f\u8d23\u4eba\u7530\u4eac\u4f1f\u535a\u58eb\u8868\u793a\uff1a<\/b>&quot;\u6291\u90c1\u75c7\u6709\u7740\u590d\u6742\u4e14\u591a\u5143\u7684\u75c7\u72b6\u8868\u73b0\uff0c\u901a\u8fc7\u591a\u9776\u70b9\u7684\u5e72\u9884\u6cbb\u7597\u53ef\u5b9e\u73b0\u66f4\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u82e5\u6b23\u6797<sup>&reg;<\/sup>\u662f\u4e00\u4e2a\u4ece\u57fa\u7840\u7814\u7a76\u5230\u9a8c\u8bc1\u6027\u4e34\u5e8a\u5747\u5f97\u5230\u8bc1\u5b9e\u7684SNDRI\u6297\u6291\u90c1\u836f\u7269\uff0c\u53ef\u5168\u9762\u6539\u5584\u60a3\u8005\u75c7\u72b6\uff0c\u4fc3\u8fdb\u793e\u4f1a\u529f\u80fd\u6062\u590d\uff0c\u4e3a\u60a3\u8005\u65e9\u65e5\u56de\u5f52\u5bb6\u5ead\u3001\u56de\u5f52\u793e\u4f1a\u63d0\u4f9b\u6709\u529b\u652f\u6301\u3002&quot;<\/p>\n<p><b>\u4e2d\u67a2\u795e\u7ecf\u9886\u57df\u4f18\u52bf\u51f8\u663e\uff0c\u670d\u52a1\u60a3\u8005\u672a\u6ee1\u8db3\u9700\u6c42<\/b><\/p>\n<p><b>\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u603b\u88c1\u6768\u8363\u5175\u8868\u793a<\/b>\uff1a&quot;\u6291\u90c1\u75c7\u4f5c\u4e3a\u6211\u56fd\u6700\u4e3a\u666e\u904d\u7684\u7cbe\u795e\u969c\u788d\u4e4b\u4e00\uff0c\u7ed9\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u3001\u4e43\u81f3\u793e\u4f1a\u5e26\u6765\u6c89\u91cd\u7684\u75be\u75c5\u8d1f\u62c5\u3002\u82e5\u6b23\u6797<sup>&reg;<\/sup>\u7684\u83b7\u6279\u4f7f\u6211\u4eec\u500d\u611f\u632f\u594b\uff0c\u516c\u53f8\u5df2\u63d0\u524d\u505a\u597d\u5546\u4e1a\u5316\u51c6\u5907\uff0c\u5e0c\u5180\u501f\u52a9\u6211\u4eec\u5728\u4e2d\u67a2\u795e\u7ecf\u6cbb\u7597\u9886\u57df\u5df2\u79ef\u7d2f\u7684\u4f18\u52bf\uff0c\u5c3d\u5feb\u5c06\u8fd9\u4e00\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u5e26\u7ed9\u60a3\u8005\uff0c\u63d0\u5347\u521b\u65b0\u836f\u7269\u7684\u53ef\u53ca\u6027\u3002&quot;<\/p>\n<p>\u5305\u62ec\u6291\u90c1\u75c7\u5728\u5185\u7684\u4e2d\u67a2\u795e\u7ecf\u6cbb\u7597\u9886\u57df\u662f\u7eff\u53f6\u5236\u836f\u7684\u6838\u5fc3\u6218\u7565\u9886\u57df\u4e4b\u4e00\uff0c\u56f4\u7ed5\u8be5\u75be\u75c5\u9886\u57df\uff0c\u516c\u53f8\u591a\u5e74\u6765\u79ef\u6781\u6784\u5efa\u521b\u65b0\u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\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5b98\u7f51\uff1a<a href=\"https:\/\/www.who.int\/zh\/news-room\/fact-sheets\/detail\/depression\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.who.int\/zh\/news-room\/fact-sheets\/detail\/depression<\/a><br \/>2.&nbsp; CMHS\u4e2d\u56fd\u7cbe\u795e\u536b\u751f\u8c03\u67e5<br \/>3.&nbsp; \u4e2d\u56fd\u6291\u90c1\u969c\u788d\u9632\u6cbb\u6307\u5357\uff08\u7b2c\u4e8c\u7248\uff09:47<br \/>4.&nbsp; Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006 Nov;163(11):1905-17<br \/>5.&nbsp; Nierenberg AA, Husain MM, Trivedi MH, et al. Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report. Psychol Med. 2010 Jan;40(1):41-50<br \/>6.&nbsp; \u8096\u4e50, \u4e30\u96f7, \u6731\u96ea\u6cc9, \u7b49. \u4e2d\u56fd\u6291\u90c1\u75c7\u60a3\u8005\u6025\u6027\u671f\u6cbb\u7597\u540e\u6b8b\u7559\u75c7\u72b6\u7684\u73b0\u51b5\u8c03\u67e5 [J] . \u4e2d\u534e\u7cbe\u795e\u79d1\u6742\u5fd7,2017,50 (03): 175-181<br \/>7.&nbsp; Judd LL, Akiskal HS, Maser JD, et al. Major depressive disorder: a prospective study of residual subthreshold depressive symptoms as predictor of rapid relapse. J Affect Disord. 1998 Sep;50(2-3):97-108<br \/>8.&nbsp; Carvalho AF, Sharma MS, Brunoni AR, et al. The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature. Psychother Psychosom. 2016;85(5):270-88<br \/>9.&nbsp; Zhu Y, Wu Z, Sie O, et al. Causes of drug discontinuation in patients with major depressive disorder in <span class=\"xn-location\">China<\/span>. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jan 10;96:109755<br \/>10.&nbsp; Zhu H, Wang W, Sha C, et al. Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor. Front Pharmacol. 2021 Sep 14;12:741794.<br \/>11.&nbsp; Meng P, Li C, Duan S, et al. Epigenetic Mechanism of 5-HT\/NE\/DA Triple Reuptake Inhibitor on Adult Depression Susceptibility in Early Stress Mice. Front Pharmacol. 2022 Mar 17;13:848251.<br \/>12.&nbsp; Mi W, Yang F, Li H, et al. Efficacy, Safety, and Tolerability of Ansofaxine (LY03005) Extended-Release Tablet for Major Depressive Disorder: A Randomized, Double-Blind, Placebo \u2013Controlled, Dose-Finding, Phase 2 Clinical Trial. International Journal of Neuropsychopharmacology. 2022,25(3):252-260.<br \/>13.&nbsp; \u7cbe\u795e\u969c\u788d\u8bca\u7597\u89c4\u8303 (2020\u5e74\u7248):155.<br \/>14.&nbsp; Murugaiah A. M. J. Med. 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\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5b98\u7f51\uff1ahttps:\/\/www.who.int\/zh\/news-room\/fact-sheets\/detail\/depression2.&nbsp; CMHS\u4e2d\u56fd\u7cbe\u795e\u536b\u751f\u8c03\u67e53.&nbsp; \u4e2d\u56fd\u6291\u90c1\u969c\u788d\u9632\u6cbb\u6307\u5357\uff08\u7b2c\u4e8c\u7248\uff09:474.&nbsp; Rush AJ, Trivedi MH, Wisniewski SR, et al. 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