{"id":8304,"date":"2020-11-06T17:06:00","date_gmt":"2020-11-06T10:06:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/202011061706008304"},"modified":"2020-11-07T00:31:46","modified_gmt":"2020-11-06T16:31:46","slug":"%e5%8d%ab%e6%9d%90%e4%b8%8e%e5%85%a8%e7%90%83%e9%80%82%e5%ba%94%e6%80%a7%e7%a0%94%e7%a9%b6%e8%81%94%e7%9b%9f%e5%8f%8a%e5%ae%89%e8%bf%9b%e5%ae%a3%e5%b8%83%e5%9b%bd%e9%99%85covid-19%e8%af%95%e9%aa%8c","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/202011061706008304","title":{"rendered":"\u536b\u6750\u4e0e\u5168\u7403\u9002\u5e94\u6027\u7814\u7a76\u8054\u76df\u53ca\u5b89\u8fdb\u5ba3\u5e03\u56fd\u9645COVID-19\u8bd5\u9a8c\u5165\u7ec4\u9996\u4f8b\u60a3\u8005"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">\u5b89\u8fdb\u548c\u536b\u6750\u8ba1\u5212\u53c2\u4e0eREMAP-COVID\uff08\u4e00\u9879\u68c0\u9a8cCOVID-19\u4f4f\u9662\u60a3\u8005\u7684\u591a\u79cd\u6cbb\u7597\u5e72\u9884\u63aa\u65bd\u7684\u9002\u5e94\u6027\u8bd5\u9a8c\uff09\u7684\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u7814\u7a76<\/span><\/p>\n<p><span class=\"xn-subheadline\">\u9884\u8ba1\u5728REMAP\u7f51\u7edc\u5185\u7684\u591a\u4e2a\u56fd\u9645\u8bd5\u9a8c\u4e2d\u5fc3\u5bf9\u5b89\u8fdb\u7684\u963f\u666e\u65af\u7279\u548c\u536b\u6750\u7684\u4f9d\u7acb\u6258\u4f26\u8fdb\u884c\u8bc4\u4ef7<\/span><\/p>\n<p>\u4e1c\u4eac2020\u5e7411\u67086\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; <span id=\"spanHghltdb76\">\u5168\u7403\u9002<\/span>\u5e94\u6027\u7814\u7a76\u8054\u76df\uff08GCAR\uff09\u643a\u624b\u5b89\u8fdb\u548c\u536b\u6750\uff0c\u8fd1\u65e5\u6b63\u5f0f\u5ba3\u5e03REMAP-COVID\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u7814\u7a76\u5165\u7ec4\u9996\u4f8b\u60a3\u8005\uff0c\u8fd9\u662fREMAP-CAP\uff08\u4e00\u9879\u9488\u5bf9\u793e\u533a\u83b7\u5f97\u6027\u80ba\u708e\u7684\u968f\u673a\u3001\u5d4c\u5165\u5f0f\u3001\u591a\u56e0\u7d20\u3001\u81ea\u9002\u5e94\u5e73\u53f0\u8bd5\u9a8c\uff09\u7684\u4e00\u9879\u5b50\u7814\u7a76\uff0c\u65e8\u5728\u68c0\u9a8cCOVID-19\u4f4f\u9662\u60a3\u8005\u7684\u591a\u79cd\u6cbb\u7597\u5e72\u9884\u63aa\u65bd\uff0c\u76ee\u524d\u6b63\u5728\u8bc4\u4ef7\u5b89\u8fdb\u7684\u963f\u666e\u65af\u7279\u548c\u536b\u6750\u7684\u8bd5\u9a8c\u6027\u836f\u7269\u4f9d\u7acb\u6258\u4f26\u662f\u5426\u53ef\u4ee5\u4f5c\u4e3a\u6cbb\u7597\u836f\u7269\u3002<\/p>\n<p>REMAP-CAP\u7684\u8bbe\u8ba1\u76ee\u6807\u662f\u5728\u975e\u5927\u6d41\u884c\u75c5\u53ca\u5927\u6d41\u884c\u75c5\u73af\u5883\u4e0b\u5bfb\u627e\u9488\u5bf9\u91cd\u75c7\u80ba\u708e\u7684\u6700\u4f73\u6cbb\u7597\u65b9\u6848\u30022020\u5e742\u6708\uff0c\u5728COVID-19\u66b4\u53d1\u521d\u671f\u65f6\uff0cREMAP-CAP\u8fc5\u901f\u8f6c\u5411\u5927\u6d41\u884c\u6a21\u5f0f\uff08REMAP-COVID\u5b50\u7814\u7a76\uff09\uff0c\u6309\u7167\u5176\u521d\u8877\uff0c\u7eb3\u5165\u66f4\u591a\u4e13\u95e8\u9488\u5bf9COVID-19\u7684\u6f5c\u5728\u6cbb\u7597\u65b9\u6848\uff0c\u5e76\u5c06\u62db\u52df\u5bf9\u8c61\u6269\u5c55\u81f3COVID-19\u60a3\u8005\u3002\u672c\u8bd5\u9a8c\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5e73\u53f0\u7814\u7a76\uff0c\u5bf9\u4e0d\u540c\u901a\u8def\u6216\u4f5c\u7528\u673a\u5236\u7684\u6cbb\u7597\u65b9\u6cd5\u8fdb\u884c\u68c0\u9a8c\u3002<\/p>\n<p>\u8be5\u8bd5\u9a8c\u6b63\u5728UPMC\uff08\u5339\u5179\u5821\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\uff09\u536b\u751f\u7cfb\u7edf\u7684\u591a\u5bb6\u533b\u9662\u4ee5\u53ca\u7f8e\u56fd\u768420\u591a\u5bb6\u533b\u9662\u8fdb\u884c\u3002\u968f\u540e\u5c06\u5728\u6574\u4e2a\u8bd5\u9a8c\u7f51\u7edc\u4e2d\u589e\u52a0\u5176\u4ed6\u5168\u7403\u7814\u7a76\u4e2d\u5fc3\u3002\u5339\u5179\u5821\u5927\u5b66\u662f\u7f8e\u56fd\u533a\u57df\u534f\u8c03\u4e2d\u5fc3\u3002<\/p>\n<p>\u201c\u4e0e\u751f\u7269\u5236\u836f\u884c\u4e1a\u5408\u4f5c\u6709\u5229\u4e8e\u9ad8\u6548\u68c0\u9a8c\u5df2\u6709\u7684\u9776\u5411\u836f\u7269\uff0c\u5bf9\u4e8e\u4e86\u89e3COVID-19\u60a3\u8005\u7684\u6cbb\u7597\u6a21\u5f0f\u81f3\u5173\u91cd\u8981\u3002\u201dDerek Angus\uff0cMD.\uff0cMPH\uff0cFRCP\uff0c\u7f8e\u56fdREMAP\u4e3b\u8981\u7814\u7a76\u8005\u548cUPMC\u536b\u751f\u7cfb\u7edf\u9996\u5e2d\u533b\u7597\u4fdd\u5065\u521b\u65b0\u5b98\u8c08\u5230\uff0c\u201c\u4eca\u5929\u7684\u516c\u544a\u6807\u5fd7\u7740\u751f\u7269\u5236\u836f\u884c\u4e1a\u3001\u79d1\u5b66\u754c\u548c\u5b66\u672f\u754c\u643a\u624b\u5408\u4f5c\u7684\u4e00\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u65e8\u5728\u805a\u4f17\u5bb6\u4e4b\u529b\u5171\u540c\u8bc4\u4f30\u9488\u5bf9COVID-19\u4f4f\u9662\u60a3\u8005\u7684\u6709\u524d\u666f\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u201d<\/p>\n<p>\u5b89\u8fdb\u7684\u963f\u666e\u65af\u7279\u662f\u4e00\u79cd\u53e3\u670d\u836f\u7269\uff0c\u53ef\u6291\u5236PDE4\uff08\u78f7\u9178\u4e8c\u916f\u91764\uff0c\u4e00\u79cd\u5728\u4eba\u4f53\u708e\u75c7\u7ec6\u80de\u4e2d\u53d1\u73b0\u7684\u9176\uff09\u7684\u6d3b\u6027\u3002\u963f\u666e\u65af\u7279\u53ef\u901a\u8fc7\u6291\u5236PDE4\uff0c\u8c03\u8282\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u5176\u4ed6\u4ecb\u8d28\u7684\u4ea7\u751f\uff0c\u56e0\u6b64\u53ef\u80fd\u6709\u52a9\u4e8e\u6291\u5236COVID-19\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0e\u708e\u75c7\u53cd\u5e94\u76f8\u5173\u7684\u75c7\u72b6\u3001\u4f53\u5f81\u53ca\u80ba\u90e8\u5f81\u8c61\u3002\u963f\u666e\u65af\u7279\u53e3\u670d\u5236\u5242\u76ee\u524d\u5df2\u5728\u8d85\u8fc745\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u708e\u6027\u75be\u75c5\uff0c\u5305\u62ec\u4e2d\u91cd\u5ea6\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u3001\u94f6\u5c51\u75c5\u5173\u8282\u708e\u548c\u4e0e\u767d\u585e\u75c5\u5f15\u8d77\u7684\u53e3\u8154\u6e83\u75a1\u3002<\/p>\n<p>\u201c\u5b89\u8fdb\u8ba4\u4e3a\uff0c\u57fa\u4e8e\u5176\u4f5c\u7528\u673a\u5236\uff0c\u963f\u666e\u65af\u7279\u53ef\u80fd\u6709\u52a9\u4e8e\u9884\u9632\u4e2d\u91cd\u5ea6COVID-19\u6210\u4eba\u60a3\u8005\u7684\u547c\u5438\u7a98\u8feb\u3002\u201d\u5b89\u8fdb\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1David M. Reese\u8c08\u5230\uff0c\u201c\u6211\u4eec\u5f88\u8363\u5e78\u52a0\u5165REMAP-COVID\uff0c\u8fd9\u662f\u4e00\u4e2a\u5229\u7528\u5e73\u53f0\u65b9\u6cd5\u7684\u91cd\u8981\u521b\u65b0\u4e3e\u63aa\uff0c\u6709\u53ef\u80fd\u5feb\u901f\u786e\u5b9a\u963f\u666e\u65af\u7279\u662f\u5426\u53ef\u4ee5\u6539\u5584\u4e2d\u91cd\u5ea6COVID-19\u4f4f\u9662\u60a3\u8005\u7684\u5065\u5eb7\u7ed3\u5c40\u3002\u201d<\/p>\n<p>\u4f9d\u7acb\u6258\u4f26\u662f\u536b\u6750\u901a\u8fc7\u5929\u7136\u4ea7\u7269\u6709\u673a\u5408\u6210\u6280\u672f\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u79cd\u8bd5\u9a8c\u6027TLR4\uff08Toll\u6837\u53d7\u4f534\uff09\u62ee\u6297\u5242\u3002\u5b83\u662f\u7c7b\u8102A\u7684\u7ed3\u6784\u7c7b\u4f3c\u7269\uff0c\u7c7b\u8102A\u662f\u7ec6\u83cc\u5185\u6bd2\u7d20\u7684\u6d3b\u6027\u836f\u6548\u6210\u5206\u3002\u572814\u9879\u4e34\u5e8a\u7814\u7a76\uff08\u5305\u62ec\u4e00\u9879\u5728\u91cd\u5ea6\u8d25\u8840\u75c7\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u5927\u578bIII\u671f\u968f\u673a\u8bd5\u9a8c\uff09\u4e2d\uff0c\u5df2\u7ecf\u89c2\u5bdf\u5230\u8be5\u62ee\u6297\u5242\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u9884\u671f\u53ef\u901a\u8fc7\u6291\u5236TLR4\u7684\u6d3b\u5316\u6765\u63a7\u5236COVID-19\u5f15\u8d77\u7684\u708e\u75c7\u548c\u6076\u5316\uff1bTLR4\u662f\u5f15\u8d77\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7684\u5404\u79cd\u7ec6\u80de\u56e0\u5b50\u57fa\u56e0\u8868\u8fbe\u4fe1\u53f7\u4f20\u9012\u7684\u6700\u4e0a\u6e38\u3002<\/p>\n<p>\u201c\u536b\u6750\u5f88\u8363\u5e78\u80fd\u591f\u53c2\u4e0e\u8fd9\u9879\u5f00\u521b\u6027\u7684REMAP-COVID\uff0c\u6211\u4eec\u5e0c\u671b\u8fd9\u9879\u7814\u7a76\u80fd\u591f\u6df1\u5165\u8bc4\u4f30\u4f9d\u7acb\u6258\u4f26\u662f\u5426\u53ef\u4ee5\u6539\u5584\u4e2d\u91cd\u5ea6COVID-19\u60a3\u8005\u7684\u5065\u5eb7\u7ed3\u5c40\u5e76\u4e14\u5f97\u51fa\u6709\u610f\u4e49\u7684\u7ed3\u8bba\u3002\u201d\u536b\u6750\u795e\u7ecf\u75c5\u5b66\u4e1a\u52a1\u7ec4\u9996\u5e2d\u533b\u7597\u5b98Lynn Kramer, M.D., FAAN\u8868\u793a\uff0c\u201c\u4f5c\u4e3a\u6211\u4eec\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\u4f7f\u547d\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u4e00\u76f4\u81f4\u529b\u4e8e\u5728\u5168\u7403\u8303\u56f4\u5185\u4e3a\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u548c\u533b\u7597\u4e13\u4e1a\u4eba\u5458\u5e26\u6765\u6539\u53d8\u3002\u201d<\/p>\n<p>GCAR\u662fREMAP-COVID\u7684\u7f8e\u56fd\u7533\u529e\u65b9\uff0c\u6b63\u5728\u52aa\u529b\u4fc3\u4f7f\u5168\u7403\u591a\u4e2a\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u52a0\u5165REMAP-COVID\u3002<\/p>\n<p>\u201cGCAR\u5f88\u9ad8\u5174\u80fd\u591f\u5229\u7528\u6211\u4eec\u5728\u5b9e\u65bd\u548c\u76d1\u7763\u521b\u65b0\u8bd5\u9a8c\u65b9\u9762\u7684\u4e13\u4e1a\u77e5\u8bc6\uff0c\u4e00\u8d77\u63a8\u8fdb\u8fd9\u9879\u91cd\u8981\u5de5\u4f5c\u3002\u201dGCAR\u9996\u5e2d\u6267\u884c\u5b98Meredith Buxton\u535a\u58eb\u8868\u793a\uff0c\u201c\u6211\u4eec\u81f4\u529b\u4e8e\u4e0e\u5236\u836f\u516c\u53f8\u548cREMAP\u7f51\u7edc\u5bc6\u5207\u5408\u4f5c\uff0c\u901a\u8fc7\u62c5\u4efb\u8fd9\u9879\u91cd\u8981\u521b\u65b0\u5e73\u53f0\u8bd5\u9a8c\u7684\u7f8e\u56fd\u7533\u529e\u65b9\uff0c\u4e3aCOVID-19\u60a3\u8005\u5bfb\u627e\u65b0\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\u3002\u201d<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.eisai.com.cn<\/p>\n<p>https:\/\/www.eisai.co.jp\/index.html<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5b89\u8fdb\u548c\u536b\u6750\u8ba1\u5212\u53c2\u4e0eREMAP-COVID\uff08\u4e00\u9879\u68c0\u9a8cCOVID-19\u4f4f\u9662\u60a3\u8005\u7684\u591a\u79cd\u6cbb\u7597\u5e72\u9884\u63aa\u65bd\u7684\u9002\u5e94\u6027\u8bd5\u9a8c\uff09\u7684\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u7814\u7a76 \u9884\u8ba1\u5728REMAP\u7f51\u7edc\u5185\u7684\u591a\u4e2a\u56fd\u9645\u8bd5\u9a8c\u4e2d\u5fc3\u5bf9\u5b89\u8fdb\u7684\u963f\u666e\u65af\u7279\u548c\u536b\u6750\u7684\u4f9d\u7acb\u6258\u4f26\u8fdb\u884c\u8bc4\u4ef7 \u4e1c\u4eac2020\u5e7411\u67086\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5168\u7403\u9002\u5e94\u6027\u7814\u7a76\u8054\u76df\uff08GCAR\uff09\u643a\u624b\u5b89\u8fdb\u548c\u536b\u6750\uff0c\u8fd1\u65e5\u6b63\u5f0f\u5ba3\u5e03REMAP-COVID\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u7814\u7a76\u5165\u7ec4\u9996\u4f8b\u60a3\u8005\uff0c\u8fd9\u662fREMAP-CAP\uff08\u4e00\u9879\u9488\u5bf9\u793e\u533a\u83b7\u5f97\u6027\u80ba\u708e\u7684\u968f\u673a\u3001\u5d4c\u5165\u5f0f\u3001\u591a\u56e0\u7d20\u3001\u81ea\u9002\u5e94\u5e73\u53f0\u8bd5\u9a8c\uff09\u7684\u4e00\u9879\u5b50\u7814\u7a76\uff0c\u65e8\u5728\u68c0\u9a8cCOVID-19\u4f4f\u9662\u60a3\u8005\u7684\u591a\u79cd\u6cbb\u7597\u5e72\u9884\u63aa\u65bd\uff0c\u76ee\u524d\u6b63\u5728\u8bc4\u4ef7\u5b89\u8fdb\u7684\u963f\u666e\u65af\u7279\u548c\u536b\u6750\u7684\u8bd5\u9a8c\u6027\u836f\u7269\u4f9d\u7acb\u6258\u4f26\u662f\u5426\u53ef\u4ee5\u4f5c\u4e3a\u6cbb\u7597\u836f\u7269\u3002 REMAP-CAP\u7684\u8bbe\u8ba1\u76ee\u6807\u662f\u5728\u975e\u5927\u6d41\u884c\u75c5\u53ca\u5927\u6d41\u884c\u75c5\u73af\u5883\u4e0b\u5bfb\u627e\u9488\u5bf9\u91cd\u75c7\u80ba\u708e\u7684\u6700\u4f73\u6cbb\u7597\u65b9\u6848\u30022020\u5e742\u6708\uff0c\u5728COVID-19\u66b4\u53d1\u521d\u671f\u65f6\uff0cREMAP-CAP\u8fc5\u901f\u8f6c\u5411\u5927\u6d41\u884c\u6a21\u5f0f\uff08REMAP-COVID\u5b50\u7814\u7a76\uff09\uff0c\u6309\u7167\u5176\u521d\u8877\uff0c\u7eb3\u5165\u66f4\u591a\u4e13\u95e8\u9488\u5bf9COVID-19\u7684\u6f5c\u5728\u6cbb\u7597\u65b9\u6848\uff0c\u5e76\u5c06\u62db\u52df\u5bf9\u8c61\u6269\u5c55\u81f3COVID-19\u60a3\u8005\u3002\u672c\u8bd5\u9a8c\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5e73\u53f0\u7814\u7a76\uff0c\u5bf9\u4e0d\u540c\u901a\u8def\u6216\u4f5c\u7528\u673a\u5236\u7684\u6cbb\u7597\u65b9\u6cd5\u8fdb\u884c\u68c0\u9a8c\u3002 \u8be5\u8bd5\u9a8c\u6b63\u5728UPMC\uff08\u5339\u5179\u5821\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\uff09\u536b\u751f\u7cfb\u7edf\u7684\u591a\u5bb6\u533b\u9662\u4ee5\u53ca\u7f8e\u56fd\u768420\u591a\u5bb6\u533b\u9662\u8fdb\u884c\u3002\u968f\u540e\u5c06\u5728\u6574\u4e2a\u8bd5\u9a8c\u7f51\u7edc\u4e2d\u589e\u52a0\u5176\u4ed6\u5168\u7403\u7814\u7a76\u4e2d\u5fc3\u3002\u5339\u5179\u5821\u5927\u5b66\u662f\u7f8e\u56fd\u533a\u57df\u534f\u8c03\u4e2d\u5fc3\u3002 \u201c\u4e0e\u751f\u7269\u5236\u836f\u884c\u4e1a\u5408\u4f5c\u6709\u5229\u4e8e\u9ad8\u6548\u68c0\u9a8c\u5df2\u6709\u7684\u9776\u5411\u836f\u7269\uff0c\u5bf9\u4e8e\u4e86\u89e3COVID-19\u60a3\u8005\u7684\u6cbb\u7597\u6a21\u5f0f\u81f3\u5173\u91cd\u8981\u3002\u201dDerek Angus\uff0cMD.\uff0cMPH\uff0cFRCP\uff0c\u7f8e\u56fdREMAP\u4e3b\u8981\u7814\u7a76\u8005\u548cUPMC\u536b\u751f\u7cfb\u7edf\u9996\u5e2d\u533b\u7597\u4fdd\u5065\u521b\u65b0\u5b98\u8c08\u5230\uff0c\u201c\u4eca\u5929\u7684\u516c\u544a\u6807\u5fd7\u7740\u751f\u7269\u5236\u836f\u884c\u4e1a\u3001\u79d1\u5b66\u754c\u548c\u5b66\u672f\u754c\u643a\u624b\u5408\u4f5c\u7684\u4e00\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u65e8\u5728\u805a\u4f17\u5bb6\u4e4b\u529b\u5171\u540c\u8bc4\u4f30\u9488\u5bf9COVID-19\u4f4f\u9662\u60a3\u8005\u7684\u6709\u524d\u666f\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u201d \u5b89\u8fdb\u7684\u963f\u666e\u65af\u7279\u662f\u4e00\u79cd\u53e3\u670d\u836f\u7269\uff0c\u53ef\u6291\u5236PDE4\uff08\u78f7\u9178\u4e8c\u916f\u91764\uff0c\u4e00\u79cd\u5728\u4eba\u4f53\u708e\u75c7\u7ec6\u80de\u4e2d\u53d1\u73b0\u7684\u9176\uff09\u7684\u6d3b\u6027\u3002\u963f\u666e\u65af\u7279\u53ef\u901a\u8fc7\u6291\u5236PDE4\uff0c\u8c03\u8282\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u5176\u4ed6\u4ecb\u8d28\u7684\u4ea7\u751f\uff0c\u56e0\u6b64\u53ef\u80fd\u6709\u52a9\u4e8e\u6291\u5236COVID-19\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u4e0e\u708e\u75c7\u53cd\u5e94\u76f8\u5173\u7684\u75c7\u72b6\u3001\u4f53\u5f81\u53ca\u80ba\u90e8\u5f81\u8c61\u3002\u963f\u666e\u65af\u7279\u53e3\u670d\u5236\u5242\u76ee\u524d\u5df2\u5728\u8d85\u8fc745\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u708e\u6027\u75be\u75c5\uff0c\u5305\u62ec\u4e2d\u91cd\u5ea6\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u3001\u94f6\u5c51\u75c5\u5173\u8282\u708e\u548c\u4e0e\u767d\u585e\u75c5\u5f15\u8d77\u7684\u53e3\u8154\u6e83\u75a1\u3002 \u201c\u5b89\u8fdb\u8ba4\u4e3a\uff0c\u57fa\u4e8e\u5176\u4f5c\u7528\u673a\u5236\uff0c\u963f\u666e\u65af\u7279\u53ef\u80fd\u6709\u52a9\u4e8e\u9884\u9632\u4e2d\u91cd\u5ea6COVID-19\u6210\u4eba\u60a3\u8005\u7684\u547c\u5438\u7a98\u8feb\u3002\u201d\u5b89\u8fdb\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1David M. Reese\u8c08\u5230\uff0c\u201c\u6211\u4eec\u5f88\u8363\u5e78\u52a0\u5165REMAP-COVID\uff0c\u8fd9\u662f\u4e00\u4e2a\u5229\u7528\u5e73\u53f0\u65b9\u6cd5\u7684\u91cd\u8981\u521b\u65b0\u4e3e\u63aa\uff0c\u6709\u53ef\u80fd\u5feb\u901f\u786e\u5b9a\u963f\u666e\u65af\u7279\u662f\u5426\u53ef\u4ee5\u6539\u5584\u4e2d\u91cd\u5ea6COVID-19\u4f4f\u9662\u60a3\u8005\u7684\u5065\u5eb7\u7ed3\u5c40\u3002\u201d \u4f9d\u7acb\u6258\u4f26\u662f\u536b\u6750\u901a\u8fc7\u5929\u7136\u4ea7\u7269\u6709\u673a\u5408\u6210\u6280\u672f\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u79cd\u8bd5\u9a8c\u6027TLR4\uff08Toll\u6837\u53d7\u4f534\uff09\u62ee\u6297\u5242\u3002\u5b83\u662f\u7c7b\u8102A\u7684\u7ed3\u6784\u7c7b\u4f3c\u7269\uff0c\u7c7b\u8102A\u662f\u7ec6\u83cc\u5185\u6bd2\u7d20\u7684\u6d3b\u6027\u836f\u6548\u6210\u5206\u3002\u572814\u9879\u4e34\u5e8a\u7814\u7a76\uff08\u5305\u62ec\u4e00\u9879\u5728\u91cd\u5ea6\u8d25\u8840\u75c7\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u5927\u578bIII\u671f\u968f\u673a\u8bd5\u9a8c\uff09\u4e2d\uff0c\u5df2\u7ecf\u89c2\u5bdf\u5230\u8be5\u62ee\u6297\u5242\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u9884\u671f\u53ef\u901a\u8fc7\u6291\u5236TLR4\u7684\u6d3b\u5316\u6765\u63a7\u5236COVID-19\u5f15\u8d77\u7684\u708e\u75c7\u548c\u6076\u5316\uff1bTLR4\u662f\u5f15\u8d77\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7684\u5404\u79cd\u7ec6\u80de\u56e0\u5b50\u57fa\u56e0\u8868\u8fbe\u4fe1\u53f7\u4f20\u9012\u7684\u6700\u4e0a\u6e38\u3002 \u201c\u536b\u6750\u5f88\u8363\u5e78\u80fd\u591f\u53c2\u4e0e\u8fd9\u9879\u5f00\u521b\u6027\u7684REMAP-COVID\uff0c\u6211\u4eec\u5e0c\u671b\u8fd9\u9879\u7814\u7a76\u80fd\u591f\u6df1\u5165\u8bc4\u4f30\u4f9d\u7acb\u6258\u4f26\u662f\u5426\u53ef\u4ee5\u6539\u5584\u4e2d\u91cd\u5ea6COVID-19\u60a3\u8005\u7684\u5065\u5eb7\u7ed3\u5c40\u5e76\u4e14\u5f97\u51fa\u6709\u610f\u4e49\u7684\u7ed3\u8bba\u3002\u201d\u536b\u6750\u795e\u7ecf\u75c5\u5b66\u4e1a\u52a1\u7ec4\u9996\u5e2d\u533b\u7597\u5b98Lynn Kramer, M.D., FAAN\u8868\u793a\uff0c\u201c\u4f5c\u4e3a\u6211\u4eec\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\u4f7f\u547d\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u4e00\u76f4\u81f4\u529b\u4e8e\u5728\u5168\u7403\u8303\u56f4\u5185\u4e3a\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u548c\u533b\u7597\u4e13\u4e1a\u4eba\u5458\u5e26\u6765\u6539\u53d8\u3002\u201d GCAR\u662fREMAP-COVID\u7684\u7f8e\u56fd\u7533\u529e\u65b9\uff0c\u6b63\u5728\u52aa\u529b\u4fc3\u4f7f\u5168\u7403\u591a\u4e2a\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u52a0\u5165REMAP-COVID\u3002 \u201cGCAR\u5f88\u9ad8\u5174\u80fd\u591f\u5229\u7528\u6211\u4eec\u5728\u5b9e\u65bd\u548c\u76d1\u7763\u521b\u65b0\u8bd5\u9a8c\u65b9\u9762\u7684\u4e13\u4e1a\u77e5\u8bc6\uff0c\u4e00\u8d77\u63a8\u8fdb\u8fd9\u9879\u91cd\u8981\u5de5\u4f5c\u3002\u201dGCAR\u9996\u5e2d\u6267\u884c\u5b98Meredith Buxton\u535a\u58eb\u8868\u793a\uff0c\u201c\u6211\u4eec\u81f4\u529b\u4e8e\u4e0e\u5236\u836f\u516c\u53f8\u548cREMAP\u7f51\u7edc\u5bc6\u5207\u5408\u4f5c\uff0c\u901a\u8fc7\u62c5\u4efb\u8fd9\u9879\u91cd\u8981\u521b\u65b0\u5e73\u53f0\u8bd5\u9a8c\u7684\u7f8e\u56fd\u7533\u529e\u65b9\uff0c\u4e3aCOVID-19\u60a3\u8005\u5bfb\u627e\u65b0\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\u3002\u201d \u76f8\u5173\u94fe\u63a5 : http:\/\/www.eisai.com.cn https:\/\/www.eisai.co.jp\/index.html&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/202011061706008304\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-8304","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/8304","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=8304"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/8304\/revisions"}],"predecessor-version":[{"id":8305,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/8304\/revisions\/8305"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=8304"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=8304"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=8304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}