{"id":82026,"date":"2022-10-19T19:15:00","date_gmt":"2022-10-19T12:15:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022101919150082026"},"modified":"2022-10-19T22:38:58","modified_gmt":"2022-10-19T14:38:58","slug":"%e4%ba%91%e9%a1%b6%e6%96%b0%e8%80%80%e5%ae%a3%e5%b8%83mrna%e6%96%b0%e5%86%a0%e5%80%99%e9%80%89%e7%96%ab%e8%8b%97%e5%9c%a8%e6%88%90%e4%ba%ba%e5%88%9d%e6%ac%a1%e5%85%8d%e7%96%abii%e6%9c%9f%e8%af%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022101919150082026","title":{"rendered":"\u4e91\u9876\u65b0\u8000\u5ba3\u5e03mRNA\u65b0\u51a0\u5019\u9009\u75ab\u82d7\u5728\u6210\u4eba\u521d\u6b21\u514d\u75abII\u671f\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u79ef\u6781\u9876\u7ebf\u7ed3\u679c\uff0c\u5e76\u6b63\u5728\u6d77\u5916\u63d0\u4ea4\u52a0\u5f3a\u9488\u75ab\u82d7\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff0c\u672c\u5730\u5236\u9020\u5de5\u5382\u5373\u5c06\u6295\u5165\u8fd0\u8425"},"content":{"rendered":"

—<\/i>\u5019\u9009\u75ab\u82d7<\/i> PTX-COVID19-B<\/i>\u4e0e\u8f89\u745e<\/i>\/BioNTech<\/i>\u7684Comirnaty<\/i>®<\/sup>mRNA<\/i>\u75ab\u82d7\u5728\u4e2d\u548c\u6297\u4f53\u6bd4\u5bf9\u4e2d\u8fbe\u5230\u7edf\u8ba1\u5b66\u975e\u52a3\u6548\uff1b<\/i>PTX-COVID19-B<\/i>\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u5b89\u5168\u98ce\u9669\u4fe1\u53f7<\/i> —<\/i><\/p>\n

— <\/i>\u4e91\u9876\u65b0\u8000\u6b63\u5728<\/i>\u63d0<\/i>\u4ea4<\/i>\u7528\u4f5c\u52a0\u5f3a\u9488\u75ab\u82d7\u7684<\/i>III<\/i>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7<\/i> —<\/i><\/p>\n

— \u4e91\u9876\u65b0\u8000\u5b8c\u6210\u4e86\u4e34\u5e8a\u89c4\u6a21\u6280\u672f\u8f6c\u79fb\uff0c\u5728\u6d59\u6c5f\u5609\u5584\u5efa\u8bbe\u7684\u5546\u4e1a\u5316\u89c4\u6a21\u5236\u9020\u5de5\u5382\u5373\u5c06\u6295\u5165\u8fd0\u8425<\/i> —<\/i><\/p>\n

\u4e0a\u6d77<\/span>2022\u5e7410\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4e91\u9876\u65b0\u8000<\/a>\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u592a\u5e02\u573a\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u5408\u4f5c\u4f19\u4f34Providence Therapeutics Holdings Inc.\uff08\u201cProvidence\u201d\uff09\u7684mRNA\u65b0\u51a0\u5019\u9009\u75ab\u82d7PTX-COVID19-B\u5728\u8bc4\u4f30\u5176\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u514d\u75ab\u539f\u6027\u7684II\u671f\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u9876\u7ebf\u7ed3\u679c\u3002\u4e91\u9876\u65b0\u8000\u4e8e2021\u5e74\u4eceProvidence\u83b7\u5f97\u5927\u4e2d\u534e\u533a\u3001\u4e1c\u5357\u4e9a\u548c\u5df4\u57fa\u65af\u5766PTX-COVID19-B\u7684\u76f8\u5e94\u6743\u76ca\uff0c\u540c\u65f6\u8fd8\u5efa\u7acb\u4e86\u5e7f\u6cdb\u7684\u5408\u4f5c\uff0c\u4ee5\u5229\u7528\u8be5\u6280\u672f\u5e73\u53f0\u5728\u5168\u7403\u5f00\u53d1mRNA\u4ea7\u54c1\u3002<\/p>\n

PTX-COVID19-B\u5728\u7b2c\u4e8c\u5242\u808c\u5185\u6ce8\u5c04\u63a5\u79cd\u4e24\u5468\u540e\u89c2\u5bdf\u5230\u7684\u4e2d\u548c\u6297\u4f53\u51e0\u4f55\u5e73\u5747\u6ef4\u5ea6\uff08GMT\uff09\u6bd4\u503c\u65b9\u9762\uff0c\u4e0e\u7f8e\u56fdFDA\u6279\u51c6\u7684mRNA\u75ab\u82d7Comirnaty®<\/sup>\uff08\u7531\u8f89\u745e\u548cBioNTech\u5171\u540c\u7814\u53d1\uff09\u8fbe\u5230\u7edf\u8ba1\u5b66\u975e\u52a3\u6548\u3002\u6b64\u5916\uff0cPTX-COVID19-B\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0eComirnaty®<\/sup>\u76f8\u4f3c\u3002<\/p>\n

\u8fd9\u9879II\u671f\u7814\u7a76\u5728\u52a0\u62ff\u5927\u548c\u5357\u975e\u7684\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u62db\u52df\u4e86565\u540d18\u81f364\u5c81\u7684\u53d7\u8bd5\u8005\u3002374\u540d\u53d7\u8bd5\u8005\u63a5\u79cd\u4e86PTX-COVID19-B\uff0c\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u8010\u53d7\u6027\u4e0eComirnaty®\u76f8\u4f3c\u3002\u4e24\u7ec4\u5728\u63a5\u79cd\u4e86\u7b2c\u4e00\u5242\u548c\u7b2c\u4e8c\u5242\u75ab\u82d7\u540e\u7684\u5f81\u96c6\u6027\u5168\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u603b\u4f53\u53d1\u751f\u7387\u76f8\u4f3c\uff1aPTX-COVID19-B\u5206\u522b\u4e3a71.6%\u548c59.0%\uff0cComirnaty®<\/sup>\u5206\u522b\u4e3a74.2%\u548c62.4%\u3002\u5728\u7b2c\u4e00\u5242\u548c\u7b2c\u4e8c\u5242\u63a5\u79cd\u540e\uff0cPTX-COVID19-B\u7684\u5c40\u90e8\u5f81\u96c6\u6027\u4e0d\u826f\u4e8b\u4ef6\u5206\u522b\u4e3a 62.6% \u548c 53.8%\uff0c Comirnaty®<\/sup> \u5206\u522b\u4e3a 65.1% \u548c 57.1%\u3002\u5728\u7b2c\u4e00\u6b21\u548c\u7b2c\u4e8c\u6b21\u63a5\u79cd\u540e\uff0c PTX-COVID19-B\u5168\u8eab\u6027\u5f81\u96c6\u6027\u4e0d\u826f\u4e8b\u4ef6\u5206\u522b\u4e3a 49.7% \u548c 36.9%\uff0c Comirnaty®<\/sup> \u5206\u522b\u4e3a58.6% \u548c 45.3%\u3002PTX-COVID19-B\u7ec4\u53d7\u8bd5\u8005\u62a5\u544a\u975e\u5f81\u96c6\u6027\u4e0d\u826f\u4e8b\u4ef6\u7684\u6bd4\u4f8b\u4e5f\u4e0eComirnaty®<\/sup>\u7ec4\u76f8\u4f3c\uff0853.7%\u548c52.4%\uff09\u3002\u4e24\u7ec4\u5747\u65e0\u4e0e\u63a5\u79cd\u76f8\u5173\u7684\u975e\u5f81\u96c6\u6027\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u7684\u62a5\u544a\u3002<\/p>\n

\u514d\u75ab\u539f\u6027\u5206\u6790\u8868\u660e\uff0c\u63a5\u79cd\u4e24\u5242PTX-COVID19-B\u75ab\u82d72\u5468\u540e\u4ea7\u751f\u7684\u4e2d\u548c\u6297\u4f53\u6ef4\u5ea6GMT\u4e0eComirnaty®<\/sup>\u76f8\u6bd4\u8fbe\u5230\u7edf\u8ba1\u5b66\u975e\u52a3\u6548\uff080.84\uff0c95%\u53ef\u4fe1\u533a\u95f4\uff1a0.69-1.02\uff09\u3002\u63a5\u79cd\u7b2c2\u52422\u5468\u540e\u7684\u5206\u6790\u4e5f\u8868\u660e\u8840\u6e05\u5e94\u7b54\u7387\u540c\u6837\u5177\u6709\u975e\u52a3\u6548\u3002\u5728\u8840\u6e05\u5b66\u8bc1\u5b9e\u65e0\u65e2\u5f80\u611f\u67d3\u6216\u63a5\u79cd\u75ab\u82d7\u7684\u4eba\u7fa4\u4e2d\u8fdb\u884c\u4e86\u4e00\u9879\u91cd\u8981\u7684\u4e9a\u7ec4\u5206\u6790\uff0cPTX-COVID19-B\u5728\u7b2c\u4e8c\u5242\u75ab\u82d7\u63a5\u79cd\u4e24\u5468\u540e\u8bf1\u5bfc\u7684\u514d\u75ab\u5e94\u7b54\u975e\u52a3\u6548\u4e8eComirnaty®<\/sup>\uff081.23\uff0c95%\u53ef\u4fe1\u533a\u95f4\uff1a0.95-1.58\uff09\u3002<\/p>\n

\u4e91\u9876\u65b0\u8000\u9996\u5e2d\u6267\u884c\u5b98\u7f57\u6c38\u5e86\u8868\u793a\uff1a\u201c\u795d\u8d3a\u6211\u4eec\u7684mRNA\u65b0\u51a0\u5019\u9009\u75ab\u82d7\u5728II\u671f\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u4e86\u4ee4\u4eba\u632f\u594b\u7684\u6570\u636e\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0c\u8fd9\u662f\u7b2c\u4e00\u9879\u76f4\u63a5\u5c06\u5019\u9009\u75ab\u82d7\u4e0e\u5df2\u83b7\u6279mRNA\u75ab\u82d7\u8fdb\u884c\u5934\u5bf9\u5934\u5bf9\u6bd4\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u6211\u4eec\u5c06\u81f4\u529b\u4e8e\u5feb\u901f\u542f\u52a8III\u671f\u8bd5\u9a8c\uff0c\u5e76\u5c3d\u5feb\u5728\u6388\u6743\u5730\u533a\u63a8\u51fa\u6211\u4eec\u7684\u65b0\u51a0\u75ab\u82d7\u3002\u81ea\u4e0eProvidence\u7684\u4ea4\u6613\u5b8c\u6210\u4ee5\u6765\uff0c\u6211\u4eec\u5df2\u7ecf\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\uff0c\u5305\u62ec\u5b8c\u6210\u4e86\u4e34\u5e8a\u89c4\u6a21\u7684\u6280\u672f\u8f6c\u79fb\uff0c\u5728\u6d59\u6c5f\u5609\u5584\u5efa\u8bbe\u7684\u5546\u4e1a\u5316\u89c4\u6a21\u672c\u5730\u5236\u9020\u5de5\u5382\u5373\u5c06\u6295\u5165\u8fd0\u8425\u3002\u6211\u4eec\u671f\u5f85\u5e94\u7528\u8fd9\u4e00\u5148\u8fdb\u7684\u4e14\u7ecf\u8fc7\u4e34\u5e8a\u9a8c\u8bc1\u7684 mRNA\u6280\u672f \u5e73\u53f0\uff0c\u5e76\u5c06\u5176\u4f5c\u4e3a\u4e91\u9876\u65b0\u8000mRNA\u75ab\u82d7\u53ca\u65b0\u836f\u4e1a\u52a1\u7684\u957f\u671f\u589e\u957f\u52a8\u529b\u3002\u201d<\/p>\n

\u4e91\u9876\u65b0\u8000\u6b63\u5728\u63d0\u4ea4\u4e0e\u5408\u4f5c\u4f19\u4f34\u8054\u5408\u5f00\u5c55\u7684 III\u671f\u4e34\u5e8a\u8bd5\u9a8c (IND) \u7533\u8bf7\uff0c\u4ee5\u8bc4\u4f30 PTX-COVID19-B \u4f5c\u4e3a\u52a0\u5f3a\u9488\u7684\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u3002\u672c\u516c\u53f8\u8ba1\u5212\u4e8e 2022 \u5e74\u4e0b\u534a\u5e74\u5728\u4e2d\u56fd\u548c\u5176\u4ed6\u4e91\u9876\u65b0\u8000\u6388\u6743\u533a\u57df\u9488\u5bf9\u5965\u5bc6\u514b\u620e\uff08 Omicron \uff09\u7684\u4e8c\u4ef7\u52a0\u5f3a\u9488\u5019\u9009\u75ab\u82d7EVER-COVID19-M1.2 \u63d0\u4ea4\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u3002<\/p>\n

\u4f4d\u4e8e\u6d59\u6c5f\u5609\u5584\uff0c\u5360\u5730\u9762\u79ef85\u4ea9\u3001\u6709\u7740\u76f8\u5f53\u6295\u8d44\u89c4\u6a21\u548c\u5148\u8fdb\u8bbe\u65bd\u7684mRNA\u75ab\u82d7\u5236\u9020\u5de5\u5382\u5373\u5c06\u6295\u5165\u8fd0\u8425\uff0c\u8fd9\u5c06\u4f7f\u4e91\u9876\u65b0\u8000\u80fd\u591f\u66f4\u597d\u5730\u5b9e\u73b0mRNA\u6280\u672f\u5e73\u53f0\u7684\u672c\u571f\u5316\u7814\u53d1\u3001\u751f\u4ea7\u4ee5\u53ca\u9ad8\u6548\u7684\u5546\u4e1a\u5316\u8fd0\u8425\uff0c\u7acb\u8db3\u4e2d\u56fd\uff0c\u653e\u773c\u4e9a\u6d32\u5e02\u573a\u5bf9mRNA\u75ab\u82d7\u53ca\u521b\u65b0\u836f\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u3002<\/p>\n

\u5173\u4e8e<\/b>II<\/b>\u671f\u7814\u7a76<\/b>PRO-CL-002<\/b><\/p>\n

PRO-CL-002\uff08ClinicalTrials.gov\u7f16\u53f7 NCT05175742\uff09\u662f\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u968f\u673a\u3001\u53cc\u6a21\u62df\u3001\u89c2\u5bdf\u8005\u76f2\u7684II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4ef740\u03bcg PTX-COVID19-B\u76f8\u6bd4Comirnaty®<\/sup>\u572818\u81f364\u5c81\u5065\u5eb7\u3001SARS-CoV-2\u8840\u6e05\u9634\u6027\u6210\u4eba\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u514d\u75ab\u539f\u6027\u3002\u53d7\u8bd5\u8005\u4ee52:1\u7684\u6bd4\u4f8b\u88ab\u968f\u673a\u5206\u914d\u63a5\u79cd\u4e24\u5242PTX-COVID19-B\uff08\u4e24\u5242\u95f4\u96944\u5468[\u8ba1\u5212n=350]\uff09\u6216Comirnaty®<\/sup>\uff08\u4e24\u5242\u95f4\u96943\u5468[\u8ba1\u5212n=175]\uff09\u3002\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4ef7PTX-COVID19-B\u5728\u7b2c\u4e8c\u5242\u63a5\u79cd\u56db\u5468\u540e\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u514d\u75ab\u539f\u6027\u7ec8\u70b9\u5728\u7b2c\u4e8c\u5242\u63a5\u79cd\u4e24\u5468\u540e\u8fdb\u884c\u68c0\u6d4b\uff0c\u5305\u62ecPTX-COVID19-B\u4e0eComirnaty®<\/sup>\u76f8\u6bd4\u7684\u4e2d\u548c\u6297\u4f53\u51e0\u4f55\u5e73\u5747\u6ef4\u5ea6\uff08GMT\uff09\u6bd4\u503c\u4ee5\u53ca\u8840\u6e05\u8f6c\u6362\u7387\u6bd4\u8f83\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u7684\u6700\u7ec8\u5206\u6790\u5c06\u5305\u62ec\u6240\u6709\u53d7\u8bd5\u8005\u5728\u7b2c\u4e00\u5242\u63a5\u79cd\u540e12\u4e2a\u6708\u7684\u968f\u8bbf\uff0c\u4ee5\u8bc4\u4f30\u5019\u9009\u75ab\u82d7\u7684\u5b89\u5168\u6027\u548c\u514d\u75ab\u5e94\u7b54\u6301\u4e45\u6027\u3002<\/p>\n

\u5173\u4e8e<\/b>PTX-COVID19-B<\/b><\/p>\n

PTX-COVID19-B\u662f\u4e00\u6b3emRNA\u5019\u9009\u75ab\u82d7\uff0c\u53ef\u8bf1\u5bfc\u4ea7\u751f\u9488\u5bf9SARS-CoV-2\u523a\u7a81\u86cb\u767d\u7684\u5f3a\u6548\u4e2d\u548c\u6297\u4f53\uff0c\u4ece\u800c\u52a0\u5f3a\u5bf9\u65b0\u51a0\u80ba\u708eCOVID-19\u7684\u514d\u75ab\u4fdd\u62a4\u3002PTX-COVID19-B\u9488\u5bf9 SARS-CoV-2\u7684\u539f\u59cb\u6bd2\u682a\uff0c\u5e76\u53ef\u4e3a\u6b63\u5728\u5f00\u53d1\u7684\u9488\u5bf9\u5f53\u524d\u53ca\u4eca\u540e\u7684SARS-CoV-2\u53d8\u5f02\u6bd2\u682a\u548c\u548c\u5176\u4ed6\u03b2-\u51a0\u72b6\u75c5\u6bd2\u7684\u591a\u4ef7\u75ab\u82d7\u505a\u597d\u51c6\u5907\u3002<\/p>\n

2021\u5e749\u6708\uff0c\u4e91\u9876\u65b0\u8000\u4e0eProvidence Therapeutics Holdings Inc.\uff08\u201cProvidence\u201d\uff09\u7b7e\u8ba2\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u4ee5\u5171\u540c\u63a8\u8fdbmRNA\u75ab\u82d7\u53ca\u7597\u6cd5\u7684\u7814\u53d1\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u4e91\u9876\u65b0\u8000\u62e5\u6709\u5728\u5927\u4e2d\u534e\u533a\u3001\u6587\u83b1\u3001\u67ec\u57d4\u5be8\u3001\u5370\u5ea6\u5c3c\u897f\u4e9a\u3001\u8001\u631d\u3001\u9a6c\u6765\u897f\u4e9a\u3001\u7f05\u7538\u3001\u5df4\u57fa\u65af\u5766\u3001\u83f2\u5f8b\u5bbe\u3001\u65b0\u52a0\u5761\u3001\u6cf0\u56fd\u3001\u4e1c\u5e1d\u6c76\u548c\u8d8a\u5357\u83b7\u5f97Providence\u7684mRNA\u5019\u9009\u75ab\u82d7\u7684\u6743\u5229\u3002\u4e91\u9876\u65b0\u8000\u8fd8\u4e0eProvidence\u8fbe\u6210\u4e86\u4e00\u9879\u5168\u7403\u5408\u4f5c\uff0c\u6839\u636e\u5408\u4f5c\u534f\u8bae\uff0c\u5728\u5b8c\u5168\u6280\u672f\u8f6c\u8ba9\u76f8\u5173\u6761\u6b3e\u7684\u652f\u6301\u4e0b\uff0c\u4e91\u9876\u65b0\u8000\u80fd\u591f\u5229\u7528Providence\u7684mRNA\u5e73\u53f0\u7814\u53d1\u4ea7\u54c1\uff0c\u4ee5\u5728\u5e7f\u6cdb\u7684\u5176\u4ed6\u9884\u9632\u548c\u6cbb\u7597\u9886\u57df\u8fdb\u884c\u836f\u7269\u53d1\u73b0\u3002<\/p>\n

\u5173\u4e8e\u4e91\u9876\u65b0\u8000<\/b><\/p>\n

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\u524d\u77bb\u6027\u58f0\u660e\uff1a<\/p>\n

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—\u5019\u9009\u75ab\u82d7 PTX-COVID19-B\u4e0e\u8f89\u745e\/BioNTech\u7684Comirnaty®mRNA\u75ab\u82d7\u5728\u4e2d\u548c\u6297\u4f53\u6bd4\u5bf9\u4e2d\u8fbe\u5230\u7edf\u8ba1\u5b66\u975e\u52a3\u6548\uff1bPTX-COVID19-B\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u5b89\u5168\u98ce\u9669\u4fe1\u53f7 — — \u4e91\u9876\u65b0\u8000\u6b63\u5728\u63d0\u4ea4\u7528\u4f5c\u52a0\u5f3a\u9488\u75ab\u82d7\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7 — — \u4e91\u9876\u65b0\u8000\u5b8c\u6210\u4e86\u4e34\u5e8a\u89c4\u6a21\u6280\u672f\u8f6c\u79fb\uff0c\u5728\u6d59\u6c5f\u5609\u5584\u5efa\u8bbe\u7684\u5546\u4e1a\u5316\u89c4\u6a21\u5236\u9020\u5de5\u5382\u5373\u5c06\u6295\u5165\u8fd0\u8425 — \u4e0a\u6d772022\u5e7410\u670819\u65e5 \/\u7f8e\u901a\u793e\/ — \u4e91\u9876\u65b0\u8000\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u592a\u5e02\u573a\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u5408\u4f5c\u4f19\u4f34Providence Therapeutics Holdings Inc.\uff08\u201cProvidence\u201d\uff09\u7684mRNA\u65b0\u51a0\u5019\u9009\u75ab\u82d7PTX-COVID19-B\u5728\u8bc4\u4f30\u5176\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u514d\u75ab\u539f\u6027\u7684II\u671f\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u9876\u7ebf\u7ed3\u679c\u3002\u4e91\u9876\u65b0\u8000\u4e8e2021\u5e74\u4eceProvidence\u83b7\u5f97\u5927\u4e2d\u534e\u533a\u3001\u4e1c\u5357\u4e9a\u548c\u5df4\u57fa\u65af\u5766PTX-COVID19-B\u7684\u76f8\u5e94\u6743\u76ca\uff0c\u540c\u65f6\u8fd8\u5efa\u7acb\u4e86\u5e7f\u6cdb\u7684\u5408\u4f5c\uff0c\u4ee5\u5229\u7528\u8be5\u6280\u672f\u5e73\u53f0\u5728\u5168\u7403\u5f00\u53d1mRNA\u4ea7\u54c1\u3002 PTX-COVID19-B\u5728\u7b2c\u4e8c\u5242\u808c\u5185\u6ce8\u5c04\u63a5\u79cd\u4e24\u5468\u540e\u89c2\u5bdf\u5230\u7684\u4e2d\u548c\u6297\u4f53\u51e0\u4f55\u5e73\u5747\u6ef4\u5ea6\uff08GMT\uff09\u6bd4\u503c\u65b9\u9762\uff0c\u4e0e\u7f8e\u56fdFDA\u6279\u51c6\u7684mRNA\u75ab\u82d7Comirnaty®\uff08\u7531\u8f89\u745e\u548cBioNTech\u5171\u540c\u7814\u53d1\uff09\u8fbe\u5230\u7edf\u8ba1\u5b66\u975e\u52a3\u6548\u3002\u6b64\u5916\uff0cPTX-COVID19-B\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0eComirnaty®\u76f8\u4f3c\u3002 \u8fd9\u9879II\u671f\u7814\u7a76\u5728\u52a0\u62ff\u5927\u548c\u5357\u975e\u7684\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u62db\u52df\u4e86565\u540d18\u81f364\u5c81\u7684\u53d7\u8bd5\u8005\u3002374\u540d\u53d7\u8bd5\u8005\u63a5\u79cd\u4e86PTX-COVID19-B\uff0c\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u8010\u53d7\u6027\u4e0eComirnaty®\u76f8\u4f3c\u3002\u4e24\u7ec4\u5728\u63a5\u79cd\u4e86\u7b2c\u4e00\u5242\u548c\u7b2c\u4e8c\u5242\u75ab\u82d7\u540e\u7684\u5f81\u96c6\u6027\u5168\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u603b\u4f53\u53d1\u751f\u7387\u76f8\u4f3c\uff1aPTX-COVID19-B\u5206\u522b\u4e3a71.6%\u548c59.0%\uff0cComirnaty®\u5206\u522b\u4e3a74.2%\u548c62.4%\u3002\u5728\u7b2c\u4e00\u5242\u548c\u7b2c\u4e8c\u5242\u63a5\u79cd\u540e\uff0cPTX-COVID19-B\u7684\u5c40\u90e8\u5f81\u96c6\u6027\u4e0d\u826f\u4e8b\u4ef6\u5206\u522b\u4e3a 62.6% \u548c 53.8%\uff0c Comirnaty® \u5206\u522b\u4e3a 65.1% \u548c 57.1%\u3002\u5728\u7b2c\u4e00\u6b21\u548c\u7b2c\u4e8c\u6b21\u63a5\u79cd\u540e\uff0c 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