{"id":81913,"date":"2022-10-18T07:00:00","date_gmt":"2022-10-18T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022101807000081913"},"modified":"2022-10-18T23:06:59","modified_gmt":"2022-10-18T15:06:59","slug":"%e5%ba%94%e4%b8%96%e7%94%9f%e7%89%a9%e5%9c%a82022%e5%b9%b4%e5%9b%bd%e9%99%85%e9%bb%91%e8%89%b2%e7%b4%a0%e7%98%a4%e5%ad%a6%e4%bc%9a%ef%bc%88smr%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83in10","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022101807000081913","title":{"rendered":"\u5e94\u4e16\u751f\u7269\u57282022\u5e74\u56fd\u9645\u9ed1\u8272\u7d20\u7624\u5b66\u4f1a\uff08SMR\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03IN10018\u4e34\u5e8a\u7814\u7a76\u6570\u636e"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5357\u4eac<\/span>2022\u5e7410\u670818\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u805a\u7126\u7a81\u7834\u5b9e\u4f53\u7624\u8010\u836f\u7684\u5168\u7403\u521b\u65b0\u836f\u7814\u53d1\u516c\u53f8\u5e94\u4e16\u751f\u7269\u5ba3\u5e03\u5728\u7b2c19\u5c4a\u56fd\u9645\u9ed1\u8272\u7d20\u7624\u5b66\u4f1a\uff08SMR\uff09\u5e74\u4f1a\u516c\u5e03\u65d7\u4e0b\u5728\u7814\u7ba1\u7ebfIN10018 \u4e00\u9879\u5728\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5f00\u5c55\u7684Ib \u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u7ed3\u679c\uff0c\u8be5\u9879\u7814\u7a76\u5728\u5927\u4f1a\u671f\u95f4\u5c06\u4ee5\u58c1\u62a5\uff08Abstract #\uff1aP-141\uff09\u5f62\u5f0f\u5c55\u51fa\u3002\u6570\u636e\u663e\u793a\uff0cIN10018\u5728\u6cbb\u7597\u8461\u8404\u819c\u9ed1\u8272\u7d20\u7624\uff08Uveal Melanoma\uff0cUM\uff09\u548cNRAS\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6781\u5177\u6f5c\u529b\u7684\u6297\u80bf\u7624\u7597\u6548\u548c\u826f\u597d\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\n<\/p><\/div>\n

IN10018\u662f\u4e00\u79cd\u9ad8\u6548\u548c\u9ad8\u9009\u62e9\u6027\u7684\u9ecf\u7740\u6591\u6fc0\u9176\uff08Focal Adhesion Kinase\uff0cFAK\uff09\u6291\u5236\u5242\uff0c\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u5305\u62ec\u94c2\u8010\u836f\u590d\u53d1\u5375\u5de2\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u3001KRAS G12C\u7a81\u53d8\u80bf\u7624\u3001\u80f0\u817a\u764c\u7b49\u591a\u79cd\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\uff0c\u5176\u4e2dIN10018\u8054\u5408PLD\u6cbb\u7597\u94c2\u8010\u836f\u590d\u53d1\u5375\u5de2\u764c\u5df2\u4e8e2021\u5e748\u6708\u83b7\u5f97\u4e86\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u5feb\u901f\u901a\u9053\u8ba4\u8bc1\uff0c\u5e76\u4e8e\u4eca\u5e744\u6708\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\uff08NMPA\uff09\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u3002<\/p>\n

\u6b64\u6b21\u4f1a\u8bae\u516c\u5e03\u7684\u8fd9\u9879 Ib \u671f\u7814\u7a76\u65e8\u5728\u8bc4\u4f30 IN10018 \u5355\u836f\u6216\u4e0eMEK\u6291\u5236\u5242Cobimetinib \uff08Cobi\uff09\u8054\u5408\u6cbb\u7597UM \u6216 NRAS \u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6297\u80bf\u7624\u7597\u6548\u3002\u8be5\u7814\u7a76\u6b63\u5728\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5171\u8ba18 \u4e2a\u4e2d\u5fc3\u8fdb\u884c\u3002 \u622a\u81f3 2022 \u5e74 6 \u6708 30 \u65e5\uff0c\u5171\u6709 45 \u540d UM \u6216 NRAS\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5165\u7ec4\uff0c\u5176\u4e2d 93% \u60a3\u8005\u5728\u6b64\u524d\u63a5\u53d7\u8fc7\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u3002 IN10018 100 mg QD \u5355\u836f\u6216\u4e0e Cobi 60 mg \u8054\u7528\u88ab\u786e\u5b9a\u4e3a\u63a8\u8350\u5242\u91cf\u3002Cobi\u7531\u7f57\u6c0f\u7814\u53d1\u4e0a\u5e02\uff0c\u6b64\u524d\u516c\u53f8\u4e0e\u7f57\u6c0f\u8fbe\u6210IN10018\u4e0eCobi\u8054\u5408\u6cbb\u7597\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u5408\u4f5c\u3002<\/p>\n

IN10018 \u4e0e Cobi \u8054\u5408\u6cbb\u7597\u5728 UM \u6216 NRAS\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u5177\u6709\u524d\u666f\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u5728UM\u60a3\u8005\u4e2d\uff0cIN10018\u5355\u836f\u6cbb\u7597\u572810\u4f8b\u7597\u6548\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09 \u4e3a 2.73\u4e2a\u6708\uff1bIN10018 \u8054\u7528 Cobi\u6cbb\u7597\u57288 \u540d\u7597\u6548\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u7684 mPFS \u4e3a 6.52 \u4e2a\u6708\u3002\u5728NRAS\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0cIN10018\u5355\u836f\u6cbb\u7597\u57287\u4f8b\u7406\u7597\u5b66\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u7684mPFS\u4e3a 2.79\u4e2a\u6708\uff0c\u5176\u4e2d\u67091\u4f8bPR\u3002 \u66f4\u4ee4\u4eba\u632f\u594b\u7684\u7ed3\u679c\u6765\u81ea\u4e8eIN10018 \u8054\u7528 Cobi \u6cbb\u7597NRAS\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u5728 13 \u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u62a5\u544a5\u4f8b PR \u548c 5\u4f8bSD\uff0cORR \u4e3a 38.5%\uff085\/13\uff09\uff0cDCR \u4e3a 76.9%\uff0810\/13\uff09\uff0c\u4e2d\u4f4d PFS \u4e3a 5.45 \u4e2a\u6708\u3002<\/p>\n

\u5b89\u5168\u6027\u65b9\u9762\uff0cIN10018 \u4e0e Cobi \u8054\u5408\u6cbb\u7597\u4e0eIN10018\u5355\u836f\u76f8\u5f53\uff0c\u672a\u89c2\u5bdf\u5230\u6709\u6bd2\u6027\u7684\u53e0\u52a0\u3002<\/p>\n

\u5e94\u4e16\u751f\u7269\u62e5\u6709IN10018\u5168\u7403\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u8fd0\u8425\u6743\u3002\u516c\u53f8\u7684\u5357\u4eac\u8f6c\u5316\u533b\u5b66\u4e2d\u5fc3\u9488\u5bf9IN10018\u548cFAK\u9776\u70b9\u8fdb\u884c\u4e86\u539f\u521b\u673a\u5236\u63a2\u7d22\u6027\u7814\u7a76\uff0c\u5e76\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u9646\u7eed\u5728\u9ad8\u6c34\u5e73\u56fd\u9645\u5b66\u672f\u671f\u520a\u53d1\u8868\u3002\u76f8\u5173\u6570\u636e\u8868\u660eIN10018\u6709\u671b\u514b\u670d\u80bf\u7624\u57fa\u8d28\u7ea4\u7ef4\u5316\u5c4f\u969c\uff0c\u63d0\u9ad8\u5c40\u90e8\u514d\u75ab\u529f\u80fd\uff0c\u4ece\u800c\u4e0e\u9776\u5411\u6cbb\u7597\u3001\u5316\u7597\u4ee5\u53ca\u514d\u75ab\u6cbb\u7597\u7b49\u534f\u540c\u589e\u6548\uff0c\u6210\u4e3a\u8054\u5408\u7528\u836f\u7684\u65b0\u9009\u62e9\u3002IN10018\u4e34\u5e8a\u6570\u636e\u4e5f\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u591a\u764c\u79cd\u6709\u6548\u6027\u3002\u5e94\u4e16\u8ba1\u5212\u5728\u591a\u4e2a\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u548c\u4e0d\u540c\u7684\u836f\u7269\u8054\u5408\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u5c55\u4e34\u5e8a\u6982\u5ff5\u9a8c\u8bc1\u53ca\u5408\u4f5c\u5f00\u53d1\u3002 <\/p>\n

\u9664\u63a8\u8fdbIN10018\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u5916\uff0c\u516c\u53f8\u9884\u8ba1\u4eca\u5e74\u5c06\u6709\u591a\u4e2a\u5168\u65b0\u9776\u70b9\u548c\u673a\u5236\u7684\u521b\u65b0\u836f\u9879\u76ee\u5728\u4e2d\u7f8e\u4e24\u5730\u9646\u7eed\u83b7\u6279IND\u548c\u542f\u52a8\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u4e9b\u5019\u9009\u836f\u7269\u90fd\u662f\u56f4\u7ed5\u5404\u7c7b\u578b\u5b9e\u4f53\u7624\u7684\u591a\u79cd\u8010\u836f\u673a\u5236\u548c\u7ea4\u7ef4\u5316\u5fae\u73af\u5883\u534f\u540c\u5e03\u5c40\u5c55\u5f00\uff0c\u76ee\u524d\u6b63\u5728\u4e0e\u76f8\u5e94\u76d1\u7ba1\u673a\u6784\u79ef\u6781\u6c9f\u901a\u548c\u51c6\u5907\u4e2d\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5357\u4eac2022\u5e7410\u670818\u65e5 \/\u7f8e\u901a\u793e\/ — \u805a\u7126\u7a81\u7834\u5b9e\u4f53\u7624\u8010\u836f\u7684\u5168\u7403\u521b\u65b0\u836f\u7814\u53d1\u516c\u53f8\u5e94\u4e16\u751f\u7269\u5ba3\u5e03\u5728\u7b2c19\u5c4a\u56fd\u9645\u9ed1\u8272\u7d20\u7624\u5b66\u4f1a\uff08SMR\uff09\u5e74\u4f1a\u516c\u5e03\u65d7\u4e0b\u5728\u7814\u7ba1\u7ebfIN10018 \u4e00\u9879\u5728\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5f00\u5c55\u7684Ib \u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u7ed3\u679c\uff0c\u8be5\u9879\u7814\u7a76\u5728\u5927\u4f1a\u671f\u95f4\u5c06\u4ee5\u58c1\u62a5\uff08Abstract #\uff1aP-141\uff09\u5f62\u5f0f\u5c55\u51fa\u3002\u6570\u636e\u663e\u793a\uff0cIN10018\u5728\u6cbb\u7597\u8461\u8404\u819c\u9ed1\u8272\u7d20\u7624\uff08Uveal Melanoma\uff0cUM\uff09\u548cNRAS\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6781\u5177\u6f5c\u529b\u7684\u6297\u80bf\u7624\u7597\u6548\u548c\u826f\u597d\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002 IN10018\u662f\u4e00\u79cd\u9ad8\u6548\u548c\u9ad8\u9009\u62e9\u6027\u7684\u9ecf\u7740\u6591\u6fc0\u9176\uff08Focal Adhesion Kinase\uff0cFAK\uff09\u6291\u5236\u5242\uff0c\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u5305\u62ec\u94c2\u8010\u836f\u590d\u53d1\u5375\u5de2\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u3001KRAS G12C\u7a81\u53d8\u80bf\u7624\u3001\u80f0\u817a\u764c\u7b49\u591a\u79cd\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\uff0c\u5176\u4e2dIN10018\u8054\u5408PLD\u6cbb\u7597\u94c2\u8010\u836f\u590d\u53d1\u5375\u5de2\u764c\u5df2\u4e8e2021\u5e748\u6708\u83b7\u5f97\u4e86\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u5feb\u901f\u901a\u9053\u8ba4\u8bc1\uff0c\u5e76\u4e8e\u4eca\u5e744\u6708\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\uff08NMPA\uff09\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u3002 \u6b64\u6b21\u4f1a\u8bae\u516c\u5e03\u7684\u8fd9\u9879 Ib \u671f\u7814\u7a76\u65e8\u5728\u8bc4\u4f30 IN10018 \u5355\u836f\u6216\u4e0eMEK\u6291\u5236\u5242Cobimetinib \uff08Cobi\uff09\u8054\u5408\u6cbb\u7597UM \u6216 NRAS \u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6297\u80bf\u7624\u7597\u6548\u3002\u8be5\u7814\u7a76\u6b63\u5728\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u5171\u8ba18 \u4e2a\u4e2d\u5fc3\u8fdb\u884c\u3002 \u622a\u81f3 2022 \u5e74 6 \u6708 30 \u65e5\uff0c\u5171\u6709 45 \u540d UM \u6216 NRAS\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5165\u7ec4\uff0c\u5176\u4e2d 93% \u60a3\u8005\u5728\u6b64\u524d\u63a5\u53d7\u8fc7\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u3002 IN10018 100 mg QD \u5355\u836f\u6216\u4e0e Cobi 60 mg \u8054\u7528\u88ab\u786e\u5b9a\u4e3a\u63a8\u8350\u5242\u91cf\u3002Cobi\u7531\u7f57\u6c0f\u7814\u53d1\u4e0a\u5e02\uff0c\u6b64\u524d\u516c\u53f8\u4e0e\u7f57\u6c0f\u8fbe\u6210IN10018\u4e0eCobi\u8054\u5408\u6cbb\u7597\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u5408\u4f5c\u3002 IN10018 \u4e0e Cobi \u8054\u5408\u6cbb\u7597\u5728 UM \u6216 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