{"id":81718,"date":"2022-10-17T07:00:00","date_gmt":"2022-10-17T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022101707000081718"},"modified":"2022-10-17T22:32:17","modified_gmt":"2022-10-17T14:32:17","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e6%9f%b3%e5%8f%b6%e5%88%80%e5%ad%90%e5%88%8aeclinicalmedicine%e5%8f%91%e8%a1%a8mazdutide%e5%9c%a8%e4%b8%ad%e5%9b%bd%e8%b6%85%e9%87%8d%e6%88%96","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022101707000081718","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u67f3\u53f6\u5200\u5b50\u520aeClinicalMedicine\u53d1\u8868Mazdutide\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u9ad8\u5242\u91cf\u961f\u5217\u7ed3\u679c"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde<\/span><span class=\"legendSpanClass\">2022\u5e7410\u670817\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u6fc0\u52a8\u5242mazdutide\uff08IBI362\uff09\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684\u591a\u6b21\u7ed9\u836f\u5242\u91cf\u9012\u589e\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u9ad8\u5242\u91cf\u961f\u5217\u7ed3\u679c\u5728\u56fd\u9645\u77e5\u540d\u533b\u5b66\u671f\u520aeClinicalMedicine\uff08<span id=\"spanHghlt7fed\">IF: 17.03<\/span>\uff09\u5728\u7ebf\u53d1\u8868\uff08<a href=\"https:\/\/www.thelancet.com\/journals\/eclinm\/article\/PIIS2589-5370(22)00421-7\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.thelancet.com\/journals\/eclinm\/article\/PIIS2589-5370(22)00421-7\/fulltext<\/a>\uff09\u3002\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u7eaa\u7acb\u519c\u6559\u6388\u548c\u9ad8\u857e\u8389\u6559\u6388\u4e3a\u8be5\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u7eaa\u7acb\u519c\u6559\u6388\u548c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb\u4e3a\u8be5\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30mazdutide\u591a\u6b21\u5242\u91cf\u9012\u589e\u7ed9\u836f\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\/\u836f\u6548\u52a8\u529b\u5b66\u7279\u5f81\u7684\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\uff08NCT04440345\uff09\u3002\u4f4e\u5242\u91cf\uff083 mg\u30014.5 mg\u548c6.0 mg\uff09\u961f\u5217\u7ed3\u679c\u5df2\u4e8e2021\u5e74\u53d1\u8868\u4e8eeClinicalMedicine<sup><span id=\"spanHghlt66ea\">[<\/span><\/sup><span id=\"spanHghlt66ea\"><sup>1]<\/sup><\/span>\u3002\u672c\u6b21\u53d1\u8868\u7684\u662f\u9ad8\u5242\u91cf\uff089 mg\u548c10 mg\uff09\u961f\u5217\u7684\u7ed3\u679c\u3002\u9ad8\u5242\u91cf\u961f\u5217\u5171\u5165\u7ec424\u4f8b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\uff0c\u6bcf\u4e2a\u961f\u5217\u4e2d12\u4f8b\u53d7\u8bd5\u8005\u63092\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d72.5-5.0-7.5-10.0 mg\u62163.0-6.0-9.0 mg\u7684mazdutide\u5242\u91cf\u6ef4\u5b9a\u6216\u5b89\u6170\u5242\uff0c\u6bcf\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\uff0c\u6bcf\u4e2a\u5242\u91cf\u6c34\u5e73\u7ed9\u836f4\u5468\u3002<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cmazdutide\u6ef4\u5b9a\u81f310 mg\u548c9 mg\u8010\u53d7\u6027\u826f\u597d\uff0c\u65e0\u53d7\u8bd5\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u9000\u51fa\u7814\u7a76\u3002\u672a\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u548c\u91cd\u5ea6\u4e0d\u826f\u4e8b\u4ef6\u3002\u6700\u5e38\u62a5\u544a\u7684\u6cbb\u7597\u671f\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u80c3\u80a0\u9053\u4e0d\u826f\u4e8b\u4ef6\uff0c\u7edd\u5927\u90e8\u5206\u4e3a\u8f7b\u5ea6\u3002\u7ed9\u836f16\u5468\u540e\uff0c10 mg\u961f\u5217\u4e2d\u63a5\u53d7mazdutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5e73\u5747\u4f53\u91cd\u8f83\u57fa\u7ebf\u4e0b\u964d7.62 kg\uff08\u767e\u5206\u6bd4\u964d\u5e459.5%\uff09\uff1b\u7ed9\u836f12\u5468\u540e\uff0c9 mg\u961f\u5217\u4e2d\u63a5\u53d7mazdutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5e73\u5747\u4f53\u91cd\u8f83\u57fa\u7ebf\u4e0b\u964d9.23 kg\uff08\u767e\u5206\u6bd4\u964d\u5e4511.7%\uff09\u3002\u63a5\u53d7mazdutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u7684BMI\u548c\u8170\u56f4\uff0c\u4ee5\u53ca\u8840\u538b\u3001\u8840\u8102\u548c\u8840\u5c3f\u9178\u7b49\u4ee3\u8c22\u6307\u6807\u7684\u6539\u5584\u4e0e\u4f4e\u5242\u91cf\u961f\u5217\u4e2d\u89c2\u5bdf\u5230\u7684\u8d8b\u52bf\u4e00\u81f4\u3002<\/p>\n<p>\u76ee\u524dmazdutide\u6709\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u8fdb\u884c\uff0c\u5176\u4e2d\u5305\u62ec1\uff09\u5728\u4e2d\u56fd\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u9ad8\u5242\u91cf\u961f\u5217\u5df2\u4e8e2022\u5e749\u6708\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f\uff0c2\uff09\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u4e8e2022\u5e7410\u6708\u83b7\u6279IND\u6b63\u5f0f\u542f\u52a8\u3002<\/p>\n<p><b>\u8be5\u9879\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u7eaa\u7acb\u519c\u6559\u6388<\/b>\u8868\u793a\uff1a&quot;\u5f88\u9ad8\u5174\u770b\u5230\u9ad8\u5242\u91cfmazdutide\u7684I\u671f\u7814\u7a76\u7ed3\u679c\u987a\u5229\u53d1\u8868\u3002\u9ad8\u5242\u91cfmazdutide\u5728I\u671f\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\uff0c\u4ee5\u53ca\u5feb\u901f\u548c\u5f3a\u5927\u7684\u51cf\u91cd\u7597\u6548\uff0c\u6709\u671b\u4e3a\u91cd\u5ea6\u80a5\u80d6\u60a3\u8005\u63d0\u4f9b\u4e0e\u51cf\u91cd\u624b\u672f\u7597\u6548\u76f8\u5ab2\u7f8e\u7684\u6cbb\u7597\u9009\u62e9\u3002\u7ed3\u5408\u4f4e\u5242\u91cfmazdutide\u7684I\u671f\u548cII\u671f\u7814\u7a76\u7ed3\u679c\uff0cmazdutide\u5df2\u6210\u4e3a\u5168\u7403\u6700\u5177\u6f5c\u529b\u7684\u521b\u65b0\u6027\u51cf\u80a5\u836f\u7269\u4e4b\u4e00\u3002\u6211\u975e\u5e38\u6709\u4fe1\u5fc3mazdutide\u5728III\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u6210\u529f\uff0c\u65e9\u65e5\u60e0\u53ca\u8d85\u91cd\u548c\u80a5\u80d6\u60a3\u8005\u3002&quot;<\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u4e34\u5e8a\u5f00\u53d1\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb<\/b>\u8868\u793a\uff1a&quot;Mazdutide 9 mg\u548c10 mg\u961f\u5217I\u671f\u7814\u7a76\u7ed3\u679c\u7684\u53d1\u8868\u8fdb\u4e00\u6b65\u4f53\u73b0\u4e86\u4e2d\u56fd\u5b66\u672f\u754c\u548c\u5de5\u4e1a\u754c\u5728\u4ee3\u8c22\u9886\u57df\u65b0\u836f\u7814\u53d1\u65e9\u671f\u7814\u7a76\u4e2d\u9ad8\u6548\u7684\u8f6c\u5316\u548c\u5408\u4f5c\u80fd\u529b\u3002Mazdutide\u9ad8\u5242\u91cf\u7684\u4e34\u5e8aI\u671f\u7ed3\u679c\u4f7f\u5176\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u51cf\u91cd\u5e45\u5ea6\u5728\u7ed9\u836f12\u5468\u5373\u8d85\u8fc711.5%\u7684\u51cf\u80a5\u5355\u836f\uff0c\u6211\u4eec\u4e5f\u975e\u5e38\u6709\u4fe1\u5fc3\u5728\u5f53\u524d\u6b63\u5728\u5f00\u5c55\u4e2d\u76849 mg \u4e34\u5e8aII\u671f\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u66f4\u52a0\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\uff0c \u4e3a\u5b9e\u73b0\u5176\u6700\u7ec8\u66ff\u4ee3\u4ee3\u8c22\u624b\u672f\u7684\u6f5c\u5728\u7597\u6cd5\u5960\u5b9a\u826f\u597d\u7684\u57fa\u7840\u3002\u540c\u65f6\uff0cmazdutide\u7684III\u671f\u7814\u7a76\u5df2\u5168\u9762\u542f\u52a8\uff0c\u671f\u5f85\u5728\u4e0d\u8fdc\u7684\u5c06\u6765\u4e3a\u4e2d\u56fd\u8d85\u91cd\u548c\u80a5\u80d6\u60a3\u8005\u63d0\u4f9b\u5168\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002&quot;<\/p>\n<p><sup><span id=\"spanHghlta928\">[1]<\/span><\/sup>Ji L, Jiang H, An P, et al. (2021) IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase <span class=\"xn-money\">1b<\/span> study. <i>EClinicalMedicine<\/i> 39: 101088. 10.1016\/j.eclinm.2021.101088<\/p>\n<p><b>\u5173\u4e8e\u80a5\u80d6<\/b><\/p>\n<p>\u6211\u56fd\u662f\u5168\u7403\u80a5\u80d6\u4eba\u53e3\u6700\u591a\u7684\u56fd\u5bb6\uff0c\u4e14\u5448\u73b0\u9010\u6e10\u4e0a\u5347\u8d8b\u52bf\u3002\u80a5\u80d6\u53ef\u4ee5\u5bfc\u81f4\u4e00\u7cfb\u5217\u5e76\u53d1\u75c7\u6216\u8005\u76f8\u5173\u75be\u75c5\uff0c\u8fdb\u800c\u5f71\u54cd\u9884\u671f\u5bff\u547d\u6216\u8005\u5bfc\u81f4\u751f\u6d3b\u8d28\u91cf\u4e0b\u964d\u3002\u5728\u8f83\u4e3a\u4e25\u91cd\u7684\u80a5\u80d6\u60a3\u8005\u4e2d\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u67d0\u4e9b\u80bf\u7624\u7684\u53d1\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u660e\u663e\u4e0a\u5347\u3002\u80a5\u80d6\u75c7\u662f\u9700\u8981\u957f\u671f\u6cbb\u7597\u7684\u6162\u6027\u75be\u75c5\uff0c\u76ee\u524d\u7f3a\u4e4f\u957f\u671f\u6709\u6548\u4e14\u5b89\u5168\u7684\u6cbb\u7597\u624b\u6bb5\u3002\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u662f\u8d85\u91cd\u6216\u80a5\u80d6\u8005\u7684\u9996\u9009\u548c\u57fa\u7840\u6cbb\u7597\u624b\u6bb5\uff0c\u4f46\u662f\u4ecd\u6709\u76f8\u5f53\u4e00\u90e8\u5206\u60a3\u8005\u7531\u4e8e\u79cd\u79cd\u539f\u56e0\u4e0d\u80fd\u8fbe\u5230\u671f\u671b\u7684\u51cf\u91cd\u76ee\u6807\uff0c\u9700\u7528\u836f\u7269\u8f85\u52a9\u51cf\u91cd\u3002\u4f20\u7edf\u51cf\u80a5\u836f\u51cf\u91cd\u6548\u679c\u6709\u9650\uff0c\u4e14\u5b58\u5728\u5b89\u5168\u95ee\u9898\u3002<\/p>\n<p><b>\u5173<\/b><b>\u4e8e<\/b><b>Mazdutide<\/b><\/p>\n<p>Mazdutide\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u4e0e\u793c\u6765\u5236\u836f\u5171\u540c\u63a8\u8fdb\u7684\u4e00\u6b3e\u80c3\u6ccc\u9178\u8c03\u8282\u7d20\u521b\u65b0\u5316\u5408\u7269\uff08OXM3\uff09\uff0c\u662f\u5177\u6709\u540c\u7c7b\u6700\u4f18\u6f5c\u529b\u7684GLP-1R\u548cGCGR\u53cc\u6fc0\u52a8\u5242\u3002\u4f5c\u4e3a\u4e00\u79cd\u4e0e\u54fa\u4e73\u52a8\u7269\u80c3\u6ccc\u9178\u8c03\u8282\u7d20\u7c7b\u4f3c\u7684\u957f\u6548\u5408\u6210\u80bd\uff0cmazdutide\u5229\u7528\u8102\u80aa\u9170\u57fa\u4fa7\u94fe\u5ef6\u957f\u4f5c\u7528\u65f6\u95f4\uff0c\u5141\u8bb8\u6bcf\u5468\u7ed9\u836f\u4e00\u6b21\u3002Mazdutide\u7684\u4f5c\u7528\u88ab\u8ba4\u4e3a\u662f\u901a\u8fc7GLP-1R\u548cGCGR\u7684\u7ed3\u5408\u548c\u6fc0\u6d3b\u4ecb\u5bfc\u7684\uff0c\u4e0eOXM\u5177\u6709\u76f8\u4f3c\u4f5c\u7528\u673a\u5236\uff0c\u56e0\u6b64\u9884\u8ba1\u5176\u53ef\u4ee5\u6539\u5584\u8461\u8404\u7cd6\u8010\u91cf\u5e76\u51cf\u8f7b\u4f53\u91cd\u3002\u9664\u4e86GLP-1R\u6fc0\u52a8\u5242\u5177\u6709\u7684\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u51cf\u8f7b\u4f53\u91cd\u7b49\u4f5c\u7528\u5916\uff0cmazdutide\u8fd8\u53ef\u80fd\u901a\u8fc7GCGR\u7684\u6fc0\u6d3b\u5177\u6709\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u548c\u6539\u5584\u809d\u810f\u8102\u80aa\u4ee3\u8c22\u7b49\u6548\u5e94\u3002\u901a\u8fc7\u5f00\u53d1\u540c\u65f6\u6fc0\u52a8\u591a\u4e2a\u4e0e\u4ee3\u8c22\u76f8\u5173\u7684\u9776\u70b9\u6765\u6cbb\u7597\u4ee3\u8c22\u6027\u75be\u75c5\u662f\u76ee\u524d\u56fd\u9645\u4e0a\u65b0\u836f\u7814\u53d1\u6700\u65b0\u7684\u8d8b\u52bf\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>&quot;\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c&quot;\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec34\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6&quot;\u91cd\u5927\u65b0\u836f\u521b\u5236&quot;\u4e13\u9879\u3002\u516c\u53f8\u5df2\u6709 8\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT<sup>&reg;<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA <sup>&reg;<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO <sup>&reg;<\/sup>\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA<sup>&reg;<\/sup>; \u4f69\u7c73\u66ff\u5c3c\u7247\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE<sup>&reg;<\/sup>; \u5965\u96f7\u5df4\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>&reg;<\/sup>; \u96f7\u83ab\u897f\u5c24\u5355\u6297\uff0c\u5546\u54c1\u540d\uff1a\u5e0c\u5189\u62e9<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aCYRAMZA<sup>&reg;<\/sup>; \u585e\u666e\u66ff\u5c3c\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c2\u4e2a\u54c1\u79cd\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c4\u4e2a\u54c1\u79cd\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670920\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a href=\"http:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7<a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"nofollow noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528&quot;\u9884\u671f&quot;\u3001&quot;\u76f8\u4fe1&quot;\u3001&quot;\u9884\u6d4b&quot;\u3001&quot;\u671f\u671b&quot;\u3001&quot;\u6253\u7b97&quot;\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e7410\u670817\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u6fc0\u52a8\u5242mazdutide\uff08IBI362\uff09\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684\u591a\u6b21\u7ed9\u836f\u5242\u91cf\u9012\u589e\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u9ad8\u5242\u91cf\u961f\u5217\u7ed3\u679c\u5728\u56fd\u9645\u77e5\u540d\u533b\u5b66\u671f\u520aeClinicalMedicine\uff08IF: 17.03\uff09\u5728\u7ebf\u53d1\u8868\uff08https:\/\/www.thelancet.com\/journals\/eclinm\/article\/PIIS2589-5370(22)00421-7\/fulltext\uff09\u3002\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u7eaa\u7acb\u519c\u6559\u6388\u548c\u9ad8\u857e\u8389\u6559\u6388\u4e3a\u8be5\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u7eaa\u7acb\u519c\u6559\u6388\u548c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb\u4e3a\u8be5\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002 \u8be5\u7814\u7a76\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30mazdutide\u591a\u6b21\u5242\u91cf\u9012\u589e\u7ed9\u836f\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\/\u836f\u6548\u52a8\u529b\u5b66\u7279\u5f81\u7684\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\uff08NCT04440345\uff09\u3002\u4f4e\u5242\u91cf\uff083 mg\u30014.5 mg\u548c6.0 mg\uff09\u961f\u5217\u7ed3\u679c\u5df2\u4e8e2021\u5e74\u53d1\u8868\u4e8eeClinicalMedicine[1]\u3002\u672c\u6b21\u53d1\u8868\u7684\u662f\u9ad8\u5242\u91cf\uff089 mg\u548c10 mg\uff09\u961f\u5217\u7684\u7ed3\u679c\u3002\u9ad8\u5242\u91cf\u961f\u5217\u5171\u5165\u7ec424\u4f8b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\uff0c\u6bcf\u4e2a\u961f\u5217\u4e2d12\u4f8b\u53d7\u8bd5\u8005\u63092\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d72.5-5.0-7.5-10.0 mg\u62163.0-6.0-9.0 mg\u7684mazdutide\u5242\u91cf\u6ef4\u5b9a\u6216\u5b89\u6170\u5242\uff0c\u6bcf\u5468\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7ed9\u836f\uff0c\u6bcf\u4e2a\u5242\u91cf\u6c34\u5e73\u7ed9\u836f4\u5468\u3002 \u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cmazdutide\u6ef4\u5b9a\u81f310 mg\u548c9 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kg\uff08\u767e\u5206\u6bd4\u964d\u5e4511.7%\uff09\u3002\u63a5\u53d7mazdutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u7684BMI\u548c\u8170\u56f4\uff0c\u4ee5\u53ca\u8840\u538b\u3001\u8840\u8102\u548c\u8840\u5c3f\u9178\u7b49\u4ee3\u8c22\u6307\u6807\u7684\u6539\u5584\u4e0e\u4f4e\u5242\u91cf\u961f\u5217\u4e2d\u89c2\u5bdf\u5230\u7684\u8d8b\u52bf\u4e00\u81f4\u3002 \u76ee\u524dmazdutide\u6709\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u8fdb\u884c\uff0c\u5176\u4e2d\u5305\u62ec1\uff09\u5728\u4e2d\u56fd\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u9ad8\u5242\u91cf\u961f\u5217\u5df2\u4e8e2022\u5e749\u6708\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f\uff0c2\uff09\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\u4e8e2022\u5e7410\u6708\u83b7\u6279IND\u6b63\u5f0f\u542f\u52a8\u3002 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\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u4e34\u5e8a\u5f00\u53d1\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb\u8868\u793a\uff1a&quot;Mazdutide 9 mg\u548c10 mg\u961f\u5217I\u671f\u7814\u7a76\u7ed3\u679c\u7684\u53d1\u8868\u8fdb\u4e00\u6b65\u4f53\u73b0\u4e86\u4e2d\u56fd\u5b66\u672f\u754c\u548c\u5de5\u4e1a\u754c\u5728\u4ee3\u8c22\u9886\u57df\u65b0\u836f\u7814\u53d1\u65e9\u671f\u7814\u7a76\u4e2d\u9ad8\u6548\u7684\u8f6c\u5316\u548c\u5408\u4f5c\u80fd\u529b\u3002Mazdutide\u9ad8\u5242\u91cf\u7684\u4e34\u5e8aI\u671f\u7ed3\u679c\u4f7f\u5176\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u51cf\u91cd\u5e45\u5ea6\u5728\u7ed9\u836f12\u5468\u5373\u8d85\u8fc711.5%\u7684\u51cf\u80a5\u5355\u836f\uff0c\u6211\u4eec\u4e5f\u975e\u5e38\u6709\u4fe1\u5fc3\u5728\u5f53\u524d\u6b63\u5728\u5f00\u5c55\u4e2d\u76849 mg \u4e34\u5e8aII\u671f\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u66f4\u52a0\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\uff0c \u4e3a\u5b9e\u73b0\u5176\u6700\u7ec8\u66ff\u4ee3\u4ee3\u8c22\u624b\u672f\u7684\u6f5c\u5728\u7597\u6cd5\u5960\u5b9a\u826f\u597d\u7684\u57fa\u7840\u3002\u540c\u65f6\uff0cmazdutide\u7684III\u671f\u7814\u7a76\u5df2\u5168\u9762\u542f\u52a8\uff0c\u671f\u5f85\u5728\u4e0d\u8fdc\u7684\u5c06\u6765\u4e3a\u4e2d\u56fd\u8d85\u91cd\u548c\u80a5\u80d6\u60a3\u8005\u63d0\u4f9b\u5168\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002&quot; [1]Ji L, Jiang H, An P, et al. (2021) IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022101707000081718\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-81718","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/81718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=81718"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/81718\/revisions"}],"predecessor-version":[{"id":81719,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/81718\/revisions\/81719"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=81718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=81718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=81718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}