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\/><span>\u8f89\u745e\u53c2\u5c55\u7b2c\u4e09\u5c4a\u8fdb\u535a\u4f1a-\u533b\u7597\u5668\u68b0\u53ca\u533b\u836f\u4fdd\u5065\u5c55\u533a\u4e3b\u5c55\u53f0<\/span><\/p>\n<\/p><\/div>\n<p>\u4f5c\u4e3a\u5168\u7403\u9886\u5148\u7684\u4ee5\u7814\u53d1\u4e3a\u57fa\u7840\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u4f01\u4e1a\u4e4b\u4e00\uff0c\u8f89\u745e\u81f4\u529b\u4e8e\u8fd0\u7528\u5168\u7403\u533b\u7597\u8d44\u6e90\u3001\u4e0e\u793e\u4f1a\u5404\u754c\u5408\u4f5c\uff0c\u79ef\u6781\u5f15\u8fdb\u521b\u65b0\u7684\u75ab\u82d7\u4ea7\u54c1\u548c\u5148\u8fdb\u7684\u514d\u75ab\u9884\u9632\u65b9\u6848\u3002\u5728\u9632\u75ab\u4e13\u533a\u5c55\u53f0\uff0c\u5c06\u56f4\u7ed5\u201c\u5f15\u9886\u3001\u521b\u65b0\u3001\u5b88\u62a4\u3001\u5f71\u54cd\u3001\u672a\u6765\u201d\u4e94\u5927\u4e3b\u9898\uff0c\u643a\u75ab\u82d7\u9886\u57df\u91cd\u78c5\u521b\u65b0\u4ea7\u54c1\u53ca\u521b\u65b0\u9879\u76ee\u4eae\u76f8\u8fdb\u535a\u4f1a\u3002\u5728\u521b\u65b0\u4ea7\u54c1\u65b9\u9762\uff0c\u8f89\u745e\u5c06\u5206\u4eab\u521b\u65b0\u4ea7\u54c120\u4ef7\u80ba\u708e\u7403\u83cc\u591a\u7cd6\u7ed3\u5408\u75ab\u82d7\uff0820vPnC\uff09\u7684\u6700\u65b0\u7814\u7a76\u6570\u636e\uff0c\u4ee5\u53ca\u5305\u62ec\u548c\u5eb7\u5e0c\u8bfa\u5408\u4f5c\u63a8\u5e7f\u7684\u56db\u4ef7\u8111\u819c\u708e\u7403\u83cc\u7ed3\u5408\u75ab\u82d7\u5728\u5185\u7684\u591a\u9886\u57df\u521b\u65b0\u75ab\u82d7\u7684\u5b9e\u8df5\u3002\u5728\u4e2d\u56fd\u4e0a\u5e02\u768413\u4ef7\u80ba\u708e\u7403\u83cc\u591a\u7cd6\u7ed3\u5408\u75ab\u82d7\uff0c\u5728\u5168\u7403120\u591a\u4e2a\u56fd\u5bb6\u5b9e\u73b0\u4e86\u5168\u4eba\u7fa4\u63a5\u79cd\uff0c\u800c\u76ee\u524d\u5728\u6211\u56fd\u53ea\u6279\u51c6\u7528\u4e8e15\u6708\u9f84\u4ee5\u4e0b\u513f\u7ae5\u7684\u9002\u5e94\u75c7\uff0c\u672c\u5c4a\u8fdb\u535a\u4f1a\u4e0a\u4e5f\u4f1a\u5411\u5927\u5bb6\u4ecb\u7ecd\u8f89\u745e\u79ef\u6781\u63a2\u7d2213\u4ef7\u80ba\u708e\u7403\u83cc\u591a\u7cd6\u7ed3\u5408\u75ab\u82d7\u5728\u4e2d\u56fd\u7684\u8001\u5e74\u4eba\u7fa4\u9002\u5e94\u75c7\u62d3\u5c55\u7684\u613f\u666f\u3002<\/p>\n<p>\u5c55\u53f0\u8fd8\u8bbe\u6709\u4f53\u611f\u5f0f\u4e92\u52a8\u5c55\u793a\u4e13\u533a\uff0c\u8ba9\u53c2\u4f1a\u8005\u53ef\u4ee5\u901a\u8fc7\u521b\u65b0\u7684\u591a\u5a92\u4f53\u65b9\u5f0f\u8eab\u4e34\u5176\u5883\u5730\u4f53\u9a8c\u8f89\u745e\u75ab\u82d7\u751f\u4ea7\u6d41\u7a0b\u4e2d\u7684\u5173\u952e\u6b65\u9aa4\u3002<\/p>\n<p>\u5728\u521b\u65b0\u9879\u76ee\u65b9\u9762\uff0c\u8f89\u745e\u5c06\u4e0e\u653f\u5e9c\u3001\u5b66\u672f\u673a\u6784\u3001\u884c\u4e1a\u4f19\u4f34\u7b49\u5f00\u5c55\u4e00\u7cfb\u5217\u521b\u65b0\u7b7e\u7ea6\u3001\u8bbf\u8c08\u7b49\u6d3b\u52a8\uff0c\u5168\u65b9\u4f4d\u5c55\u73b0\u8f89\u745e\u5728\u516c\u5171\u536b\u751f\u4f53\u7cfb\u5efa\u8bbe\u3001\u521b\u65b0\u5408\u4f5c\u4ee5\u53ca\u516c\u4f17\u5b88\u62a4\u65b9\u9762\u7684\u627f\u8bfa\uff0c\u4f20\u8fbe\u5bf9\u4e2d\u56fd\u5e02\u573a\u7684\u4fe1\u5fc3\u3002<\/p>\n<p><b>\u4ee5\u79d1\u5b66\u5f15\u9886\u521b\u65b0<\/b><\/p>\n<p>\u4f5c\u4e3a\u4e00\u5bb6\u79d1\u5b66\u3001\u521b\u65b0\u3001\u7acb\u8db3\u5168\u7403\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u8f89\u745e\u8df5\u884c\u4ee5\u60a3\u8005\u4e3a\u5148\u7684\u627f\u8bfa\uff0c\u79ef\u6781\u5f00\u5c55\u79d1\u7814\u63a2\u7d22\uff0c\u63a8\u8fdb\u79d1\u5b66\u524d\u6cbf\uff0c\u91ca\u653e\u79d1\u5b66\u7684\u6f5c\u80fd\u653b\u514b\u75be\u75c5\u3002\u540c\u65f6\uff0c\u52a0\u901f\u5c06\u7a81\u7834\u521b\u65b0\u836f\u7269\u5f15\u5165\u4e2d\u56fd\uff0c\u6301\u7eed\u63a8\u52a8\u9884\u9632\u548c\u6cbb\u7597\u9886\u57df\u53d1\u5c55\uff0c\u60e0\u53ca\u60a3\u8005\u3002<\/p>\n<p>\u5728\u672c\u6b21\u8fdb\u535a\u4f1a\u4e0a\uff0c\u8f89\u745e\u5168\u65b9\u4f4d\u5c55\u793a\u4e86\u5176\u5728<b>\u80bf\u7624\u3001\u75ab\u82d7\u3001\u7f55\u89c1\u75c5\u3001\u708e\u75c7\u4e0e\u514d\u75ab\u3001\u6297\u611f\u67d3<\/b>\u8fd9\u4e94\u5927\u9886\u57df\u7684\u7a81\u7834\u521b\u65b0\u3001\u9886\u5148\u7684\u7814\u53d1\u548c\u5168\u7403\u4f9b\u5e94\u94fe\u3001\u4ee5\u53ca\u5f3a\u5927\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002\u5728\u4e3b\u5c55\u53f0\u91cd\u78c5\u65b0\u54c1<b>\u7ef4\u4e07\u5fc3<\/b><b><sup>&reg;<\/sup><\/b><b>\u3001\u8d1d\u535a\u8428\u3001\u52b3\u62c9\u66ff\u5c3c\u3001<\/b><b>\u8212\u5766\u660e<\/b><b><sup>&reg; <\/sup><\/b>\u5907\u53d7\u77a9\u76ee\uff0c\u4e3a\u6709\u8feb\u5207\u9700\u6c42\u7684\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u4e86\u5e0c\u671b\u3002<\/p>\n<ul type=\"disc\">\n<li><b>\u5728\u7f55\u89c1\u75c5\u9886\u57df\uff0c<\/b>\u672c\u5c4a\u5c55\u4f1a\u671f\u95f4\u4e0a\u5e02\u7684\u521b\u65b0\u836f\u7269<b>\u7ef4\u4e07\u5fc3<\/b><b><sup>&reg;<\/sup><\/b>\uff08\u6c2f\u82ef\u5511\u9178\u8f6f\u80f6\u56ca\uff0cVyndamax<b><sup>&reg;<\/sup><\/b> tafamidis\uff09\u662f\u5168\u7403\u9996\u4e2a\u3001\u4e5f\u662f\u552f\u4e00\u7ecf\u8fc7\u6279\u51c6\u6cbb\u7597ATTR-CM\u60a3\u8005\u7684\u53e3\u670d\u836f\u7269\uff0c\u662f\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u91ce\u751f\u578b\u6216\u9057\u4f20\u578b\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u6dc0\u7c89\u6837\u53d8\u6027\u5fc3\u808c\u75c5\uff08ATTR-CM\uff09\u7684\u7f55\u89c1\u75c5\u521b\u65b0\u836f\u3002\u5728\u8fd1\u671f\u63ed\u6653\u7684\u76d6\u4f26\u5956\u540d\u5355\u4e2d\uff0c\u7ef4\u4e07\u5fc3<b><sup>&reg;<\/sup><\/b>\u4ee5\u5176\u521b\u65b0\u751f\u7269\u6280\u672f\u83b7\u5f97\u201c\u6700\u4f73\u751f\u7269\u6280\u672f\u4ea7\u54c1\u5956\u201d\u6b8a\u8363\u3002 <\/li>\n<li><b>\u5728\u80bf\u7624\u9886\u57df\uff0c\u8f89\u745e\u751f\u7269\u5236\u836f\u9686\u91cd\u63a8\u51fa\u4e24\u6b3e\u65b0\u54c1\uff1a<\/b>\u4e00\u6b3e\u662f\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u590d\u53d1\u6216\u96be\u6cbb\u6027B\u7ec6\u80de\u524d\u4f53\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684<b>\u8d1d\u535a\u8428<\/b>\uff08\u6ce8\u5c04\u7528\u5965\u52a0\u4f0a\u59a5\u73e0\u5355\u6297\uff0cBesponsa<b><sup>&reg;<\/sup><\/b> inotuzumab ozogamicin\uff09[1]\uff0c\u8fd9\u662f\u5168\u7403\u9996\u4e2a\u83b7\u5f97FDA\u6279\u51c6\u7684\u9776\u5411CD22\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1b\u53e6\u4e00\u6b3e\u662f\u6cbb\u7597ALK\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u7b2c\u4e09\u4ee3\u9776\u5411\u836f\u7269<b>\u52b3\u62c9\u66ff\u5c3c<\/b>\uff08Lorlatinib\uff09<b><b>[2]<\/b><\/b>\uff0c\u4e3a\u56fd\u5185\u665a\u671f\u80ba\u764c\u60a3\u8005\u6253\u7834\u8010\u836f\u56f0\u5883\u3002\u8be5\u6b3e\u4ea7\u54c1\u5728\u53bb\u5e74\u7684\u8fdb\u535a\u4f1a\u4e0a\u4eae\u76f8\u540e\uff0c\u5df2\u5728\u6d77\u5357\u535a\u9ccc\u5148\u884c\u533a\u83b7\u5f97\u5148\u884c\u5148\u8bd5\u5ba1\u6279\uff0c\u5df2\u6709\u56fd\u5185\u60a3\u8005\u9646\u7eed\u83b7\u5f97\u52b3\u62c9\u66ff\u5c3c\u5e26\u6765\u7684\u6cbb\u7597\u83b7\u76ca\u3002 <\/li>\n<li><b>\u5728\u708e\u75c7\u514d\u75ab\u9886\u57df\uff0c\u8212\u5766\u660e<\/b><b><sup>&reg;<\/sup><\/b>\uff08\u514b\u7acb\u787c\u7f57\uff0cStaquis<b><sup>&reg;<\/sup><\/b> Crisaborole\uff09\u53d7\u5230\u5f88\u5927\u5173\u6ce8\u3002\u8fd9\u6b3e\u65b0\u836f\u662f\u975e\u6fc0\u7d20\u7c7b\u521b\u65b0\u5c0f\u5206\u5b50\u5916\u7528\u5904\u65b9\u836f\uff0c\u4eca\u5e747\u6708\u5e95\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u9002\u7528\u4e8e2\u5c81\u53ca\u4ee5\u4e0a\u513f\u7ae5\u548c\u6210\u4eba\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u7279\u5e94\u6027\u76ae\u708e\u60a3\u8005\u7684\u5c40\u90e8\u5916\u7528\u6cbb\u7597\u3002\u7279\u5e94\u6027\u76ae\u708e\uff08AD\uff0c\u4e5f\u79f0\u4e3a\u7279\u5e94\u6027\u6e7f\u75b9\uff09\u662f\u6700\u5e38\u89c1\u7684\u6162\u6027\u708e\u75c7\u6027\u76ae\u80a4\u75c5 \uff0c\u4f5c\u4e3a\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u6025\u9700\u5883\u5916\u65b0\u836f\u540d\u5355\u7684\u76ae\u79d1\u5916\u7528\u836f\uff0c\u8212\u5766\u660e<sup>&reg;<\/sup>\u662f\u56fd\u5185\u7b2c\u4e00\u4e2a\u4e14\u552f\u4e00\u83b7\u6279\u7528\u4e8e\u7279\u5e94\u6027\u76ae\u708e\u7684\u5916\u7528PDE-4\u6291\u5236\u5242\u3002<\/li>\n<\/ul>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder8121\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1327819\/image_823249_52544508.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_823249_52544508.jpg\" title=\"\u8f89\u745e\u53c2\u5c55\u7b2c\u4e09\u5c4a\u8fdb\u535a\u4f1a-\u516c\u5171\u536b\u751f\u9632\u75ab\u4e13\u533a\u5c55\u53f0\" alt=\"\u8f89\u745e\u53c2\u5c55\u7b2c\u4e09\u5c4a\u8fdb\u535a\u4f1a-\u516c\u5171\u536b\u751f\u9632\u75ab\u4e13\u533a\u5c55\u53f0\" \/><\/a><br 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class=\"xn-person\">Pierre Gaudreault<\/span><\/b><b>\u8868\u793a\uff1a<\/b>\u201c\u4e2d\u56fd\u7ecf\u6d4e\u53d1\u5c55\u7684\u97e7\u6027\u5f88\u5f3a\uff0c\u6709\u76ee\u5171\u7779\uff0c\u6211\u975e\u5e38\u770b\u597d\u4e2d\u56fd\u7ecf\u6d4e\u53d1\u5c55\u957f\u671f\u5411\u597d\u7684\u6001\u52bf\u3002\u8f89\u745e\u81ea\u4e0a\u4e16\u7eaa80\u5e74\u4ee3\u8fdb\u5165\u4e2d\u56fd\u4ee5\u6765\uff0c\u966a\u4f34\u7740\u4e2d\u56fd\u533b\u836f\u5065\u5eb7\u884c\u4e1a\u4e00\u8def\u524d\u884c\u4e09\u5341\u4f59\u5e74\uff0c\u76ee\u524d\uff0c\u4e2d\u56fd\u5df2\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u533b\u836f\u5e02\u573a\uff0c\u4e5f\u662f\u8f89\u745e\u5168\u7403\u6700\u4e3a\u91cd\u8981\u7684\u5e02\u573a\u4e4b\u4e00\u3002\u8f89\u745e\u671f\u5f85\u5728\u7b2c\u4e09\u5c4a\u8fdb\u535a\u4f1a\u4e0a\u8fdb\u4e00\u6b65\u5c55\u793a\u5176\u521b\u65b0\u6210\u679c\uff0c\u5f00\u653e\u5408\u4f5c\uff0c\u4e0e\u5404\u65b9\u4f19\u4f34\u643a\u624b\u5171\u521b\u2018\u5065\u5eb7\u4e2d\u56fd2030\u2019\u7f8e\u597d\u672a\u6765\uff01\u201d<\/p>\n<p>####<\/p>\n<p><b>\u8f89\u745e\u516c\u53f8\uff1a\u4e3a\u60a3\u8005\u5e26\u6765\u6539\u53d8\u5176\u751f\u6d3b\u7684\u7a81\u7834\u521b\u65b0<\/b><\/p>\n<p>\u5728\u8f89\u745e\uff0c\u6211\u4eec\u81f4\u529b\u4e8e\u8fd0\u7528\u79d1\u5b66\u4ee5\u53ca\u6211\u4eec\u7684\u5168\u7403\u8d44\u6e90\u6765\u63d0\u4f9b\u80fd\u5ef6\u957f\u5e76\u660e\u663e\u6539\u5584\u4eba\u7c7b\u5bff\u547d\u7684\u6cbb\u7597\u3002\u5728\u533b\u7597\u536b\u751f\u4ea7\u54c1\uff08\u5305\u62ec\u521b\u65b0\u836f\u548c\u75ab\u82d7\uff09\u7684\u63a2\u7d22\u3001\u7814\u53d1\u548c\u751f\u4ea7\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u5747\u5efa\u7acb\u4e86\u8d28\u91cf\u3001\u5b89\u5168\u548c\u4ef7\u503c\u6807\u51c6\u3002\u6bcf\u5929\uff0c\u53d1\u8fbe\u548c\u65b0\u5174\u5e02\u573a\u7684\u8f89\u745e\u5458\u5de5\u90fd\u81f4\u529b\u4e8e\u63a8\u8fdb\u5065\u5eb7\uff0c\u4ee5\u53ca\u80fd\u591f\u5e94\u5bf9\u6211\u4eec\u8fd9\u4e2a\u65f6\u4ee3\u6700\u4e3a\u68d8\u624b\u7684\u75be\u75c5\u7684\u9884\u9632\u548c\u6cbb\u7597\u65b9\u6848\u3002\u8f89\u745e\u8fd8\u4e0e\u4e16\u754c\u5404\u5730\u7684\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u3001\u653f\u5e9c\u548c\u793e\u533a\u5408\u4f5c\uff0c\u652f\u6301\u4e16\u754c\u5404\u5730\u7684\u4eba\u4eec\u80fd\u591f\u83b7\u5f97\u66f4\u4e3a\u53ef\u9760\u548c\u53ef\u627f\u4ed8\u7684\u533b\u7597\u536b\u751f\u670d\u52a1\u3002\u8fd9\u4e0e\u8f89\u745e\u4f5c\u4e3a\u4e00\u5bb6\u5353\u8d8a\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u516c\u53f8\u7684\u8d23\u4efb\u662f\u4e00\u81f4\u7684\u3002170\u591a\u5e74\u6765\uff0c\u8f89\u745e\u4e00\u76f4\u52aa\u529b\u4e3a\u4eba\u4eec\u63d0\u4f9b\u66f4\u597d\u3001\u66f4\u4f18\u8d28\u7684\u670d\u52a1\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u767b\u5f55&nbsp;<a 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