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PAOLA-1 III<\/i><\/b>\u671f\u8bd5\u9a8c\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c\u663e\u793a\u51fa\u4e34\u5e8a\u751f\u5b58\u83b7\u76ca<\/i><\/b><\/p>\n

\u4e0a\u6d77<\/span>2022\u5e749\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4eca\u5929\uff0c\u963f\u65af\u5229\u5eb7\u4e0e\u9ed8\u6c99\u4e1c\u8054\u5408\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u6b63\u5f0f\u6279\u51c6\u5176PARP\u6291\u5236\u5242\u5229\u666e\u5353®<\/sup>\uff08\u82f1\u6587\u5546\u54c1\u540d\uff1aLynparza\uff0c\u901a\u7528\u540d\uff1a\u5965\u62c9\u5e15\u5229\u7247\uff09\u65b0\u9002\u5e94\u75c7\uff1a\u5965\u62c9\u5e15\u5229\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7528\u4e8e\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\u7f3a\u9677\uff08HRD\uff09\u9633\u6027\u7684\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u6210\u4eba\u60a3\u8005\u5728\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u6216\u90e8\u5206\u7f13\u89e3\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u3002\u5728\u9f13\u52b1\u533b\u836f\u521b\u65b0\u53ca\u52a0\u901f\u63a8\u8fdb\u4e34\u5e8a\u6025\u9700\u65b0\u836f\u5ba1\u6279\u7684\u653f\u7b56\u652f\u6301\u4e0b\uff0c\u5965\u62c9\u5e15\u5229\u518d\u6b21\u5728\u4e2d\u56fd\u83b7\u6279\u665a\u671f\u5375\u5de2\u764c\u4e00\u7ebf\u7ef4\u6301\u7684\u65b0\u9002\u5e94\u75c7\u3002<\/p>\n

\u6b64\u6b21\u83b7\u6279\u662f\u57fa\u4e8ePAOLA-1 III\u671f\u5173\u952e\u6027\u8bd5\u9a8c\u7ed3\u679c\u3002PAOLA-1\u8fbe\u5230\u5176\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\uff0c\u5728ITT\u60a3\u8005\u4eba\u7fa4\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\/\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u7ec4\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\/\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u7ec4\u60a3\u8005\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8641%\uff08HR 0.59\uff1b95% CI 0.49-0.72\uff1bp<0.0001\uff09\u3002\u5728HRD\u9633\u6027\u60a3\u8005\u4eba\u7fa4\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\/\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u76f8\u6bd4\uff0c\u5965\u62c9\u5e15\u5229\/\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u4e2d\u4f4dPFS\u5ef6\u957f\u4e86\u8fd120\u4e2a\u6708\uff08\u4e2d\u4f4dPFS 37.2 vs 17.7\u4e2a\u6708\uff09, \u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u4e0b\u964d67%\uff08HR 0.33\uff1b95% CI 0.25-0.45\uff09\u30022022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u4e0a\u516c\u5e03\u4e86\u6700\u65b0\u603b\u751f\u5b58\u671f\u968f\u8bbf\u6570\u636e\uff1a\u5c3d\u7ba1\u7ea650%\u7684\u5b89\u6170\u5242\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u60a3\u8005\u5728\u75be\u75c5\u8fdb\u5c55\u540e\u4ea4\u53c9\u63a5\u53d7\u4e86PARP\u6291\u5236\u5242\u7684\u6cbb\u7597\uff0c\u5965\u62c9\u5e15\u5229\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ef4\u6301\u6cbb\u7597\u4ecd\u53ef\u4e3aHRD\u9633\u6027\u60a3\u8005\u63d0\u4f9b\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u6539\u5584\uff0c5\u5e74\u5b58\u6d3b\u60a3\u8005\u6bd4\u4f8b\u9ad8\u8fbe65.5%\uff0c5\u5e74\u603b\u751f\u5b58\u7387\u8f83\u5b89\u6170\u5242\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u63d0\u9ad8\u4e8617%\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8638%\uff08HR 0.62; 95% CI 0.45-0.85\uff09\u3002<\/p>\n

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\u5173\u4e8e\u5375\u5de2\u764c<\/b><\/p>\n

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\u5173\u4e8e<\/b>PAOLA-1<\/b><\/p>\n

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2017\u5e747\u6708\uff0c\u963f\u65af\u5229\u5eb7\u4e0e\u9ed8\u6c99\u4e1c\uff08\u9ed8\u6c99\u4e1c\u662f\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u516c\u53f8\u5546\u53f7\uff09\u5ba3\u5e03\u5728\u5168\u7403\u8303\u56f4\u5185\u8fbe\u6210\u4e00\u9879\u80bf\u7624\u9886\u57df\u6218\u7565\u5408\u4f5c\uff0c\u5171\u540c\u5bf9\u5168\u7403\u9996\u4e2aPARP\u6291\u5236\u5242\u5965\u62c9\u5e15\u5229\u4ee5\u53ca\u6f5c\u529b\u65b0\u836fMEK\u6291\u5236\u5242\u53f8\u7f8e\u66ff\u5c3c\u5c31\u591a\u4e2a\u80bf\u7624\u9002\u5e94\u75c7\u8fdb\u884c\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u63a8\u5e7f\u3002<\/p>\n

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\u58f0\u660e<\/p>\n

\u4ec5\u4f9b\u53c2\u8003\u4f7f\u7528\uff0c\u4e0d\u7528\u4e8e\u4efb\u4f55\u63a8\u5e7f\u76ee\u7684\u3002\u5982\u6709\u7591\u95ee\u8bf7\u54a8\u8be2\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

\n\n\n\n\n\n\n\n\n
\n

[1]. <\/sup>World Cancer Research Fund International. Ovarian Cancer Statistics. Available at https:\/\/www.wcrf.org\/cancer-trends\/ovarian-cancer-statistics\/#:~:text=Latest%20ovarian%20cancer%20data,of%20ovarian%20cancer%20in%202020<\/a>. Accessed September 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2]. <\/sup>https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3].<\/sup> Hongmei Zeng, et al. Changing cancer survival in China during 2003\u201315: a pooled analysis of 17 population-based cancer registries[J]. Lancet Glob Health 2018; 6: e555\u201367.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[4]. <\/sup>Ledermann JA, Raja FA, Fotopoulou C, Gonzalez-Martin A, Colombo N, Sessa C. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J]. Ann Oncol 2013;24:Suppl 6:vi24-vi32<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[5].<\/sup> Raja F, et al<\/i>. Optimal first-line treatment in ovarian cancer. Ann of Oncol<\/i>. 2012;23(10):118-127.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[6]. <\/sup>NHS Choices, Ovarian Cancer Available at https:\/\/www.nhs.uk\/conditions\/ovarian-cancer\/treatment\/<\/a> Accessed September 2022.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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World Cancer Research Fund International. 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