{"id":79570,"date":"2022-09-12T19:23:00","date_gmt":"2022-09-12T12:23:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022091219230079570"},"modified":"2022-09-12T22:09:33","modified_gmt":"2022-09-12T14:09:33","slug":"%e5%8d%9a%e5%ae%89%e7%94%9f%e7%89%a9%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e5%b9%bf%e8%b0%b1%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%93ba-covmab%e6%b3%a8%e5%b0%84%e6%b6%b2%e5%9c%a8%e5%8d%8e%e8%8e%b7%e6%89%b9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022091219230079570","title":{"rendered":"\u535a\u5b89\u751f\u7269\u65b0\u51a0\u75c5\u6bd2\u5e7f\u8c31\u4e2d\u548c\u6297\u4f53BA-CovMab\u6ce8\u5c04\u6db2\u5728\u534e\u83b7\u6279\u8fdb\u5165\u4e34\u5e8a"},"content":{"rendered":"<p class=\"prntac\"><b>\u5bf9<\/b><b>Omicron<\/b><b>\u7b49\u5404\u79cd\u53d8\u5f02\u682a\u5c55\u793a\u9ad8\u6548\u4e2d\u548c\u80fd\u529b<\/b><\/p>\n<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2022\u5e749\u670812\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u8fd1\u65e5\uff0c\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u63a7\u80a1\u5b50\u516c\u53f8\u535a\u5b89\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u6cbb\u7597\/\u9884\u9632\u65b0\u51a0\u75c5\u6bd2\u80ba\u708e\u7684\u5e7f\u8c31\u4e2d\u548c\u6297\u4f53\u2014\u2014BA-CovMab\u6ce8\u5c04\u6db2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002BA-CovMab\u5bf9\u4e8eD614G\u53caAlpha\u3001Beta\u3001Delta\u3001Omicron BA.1-BA.5\u7b4918\u79cd\u75c5\u6bd2\u53d8\u5f02\u682a\u5747\u5177\u6709\u5e7f\u8c31\u9ad8\u6548\u7684\u4e2d\u548c\u80fd\u529b\uff0c\u6709\u671b\u6210\u4e3a\u5e94\u5bf9\u65b0\u51a0\u75c5\u6bd2\u53d8\u5f02\u682a\u7684\u6709\u529b\u6b66\u5668\u3002<\/p>\n<p><b>\u5bf9\u5404\u79cd\u53d8\u5f02\u682a\u5c55\u793a\u9ad8\u6548\u4e2d\u548c\u6d3b\u6027\uff0c\u5c0f\u9f20\u65b0\u51a0\u611f\u67d3\u6a21\u578b\u4e2d\u5c55\u73b0\u826f\u597d\u7597\u6548<\/b><\/p>\n<p>\u4e25\u91cd\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd22\uff08SARS-CoV-2\uff09\u9020\u6210\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u5927\u6d41\u884c\uff0c\u5bf9\u5168\u7403\u4eba\u6c11\u5065\u5eb7\u4ee5\u53ca\u7ecf\u6d4e\u5e26\u6765\u5de8\u5927\u5a01\u80c1\u3002BA-CovMab\u662f\u4e00\u6b3e\u91cd\u7ec4\u5168\u4eba\u6e90\u5355\u514b\u9686\u4e2d\u548c\u6297\u4f53\uff0c\u901a\u8fc7\u591a\u79cd\u53d8\u5f02\u682a\u7684\u8868\u9762\u523a\u7a81\u86cb\u767d\uff08Spike\uff09\/\u53d7\u4f53\u7ed3\u6784\u57df\uff08RBD\uff09\u86cb\u767d\u5e8f\u8d2f\u514d\u75ab\u548c\u5e8f\u8d2f\u7b5b\u9009\u83b7\u5f97\uff0c\u53ef\u7279\u5f02\u6027\u7ed3\u5408SARS-CoV-2\u75c5\u6bd2Spike\u86cb\u767d\u7684RBD\u533a\uff0c\u5e76\u80fd\u6709\u6548\u963b\u65ad\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u8868\u9762\u53d7\u4f53ACE2\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236SARS-CoV-2\u75c5\u6bd2\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u7684\u4fb5\u67d3\u3002\u51b7\u51bb\u7535\u955c\u7814\u7a76\u663e\u793aBA-CovMab\u7ed3\u5408\u5728RBD\u7684\u4fdd\u5b88\u8868\u4f4d\u4e0a\uff0c\u907f\u5f00\u4e86RBD\u4e2d\u7684\u5927\u591a\u6570\u7a81\u53d8\u654f\u611f\u4f4d\u70b9\uff0c\u53ef\u4ee5\u5e7f\u6cdb\u6709\u6548\u5730\u4e2d\u548cSARS-CoV-2\u5404\u79cd\u53d8\u4f53\uff0c\u4e14\u5927\u5927\u964d\u4f4e\u5bf9\u672a\u6765\u53d8\u4f53\u5931\u53bb\u4e2d\u548c\u6d3b\u6027\u7684\u98ce\u9669\u3002<\/p>\n<p>BA-CovMab\u7684\u4e34\u5e8a\u524d\u836f\u6548\u5b66\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u4f53\u5916\u5047\u75c5\u6bd2\u4e2d\u548c\u6d3b\u6027\u7ed3\u679c\u8868\u660eBA-CovMab\u53ef\u9ad8\u6548\u3001\u5e7f\u8c31\u4e2d\u548c18\u79cdSARS-CoV-2\u53d8\u5f02\u682a\uff0c\u5bf9Omicron BA.1, BA.2, BA.2.12.1, BA.2.13, BA.2.75, BA.3, BA.4\u548cBA.5\u7684\u5047\u75c5\u6bd2\u4e2d\u548c\u6d3b\u6027IC<sub>50<\/sub>\u503c\u8fbe1.24\uff5e5.52 ng\/mL\uff1b\u771f\u75c5\u6bd2\u4e2d\u548c\u6d3b\u6027\u7814\u7a76\u7ed3\u679c\u8868\u660e\u5bf9Omicron BA.1\u548cBA.2\u53d8\u5f02\u682a\u4e2d\u548c\u6d3b\u6027\u4f18\u5f02\uff0cIC<sub>50<\/sub>\u503c\u5206\u522b\u4e3a53.20\u300118.17 ng\/mL\uff1bBA-CovMab\u5bf99\u79cd\u65b0\u51a0\u6bd2\u682a\uff08WT strain\u3001B.1.1.7\u3001B.1.351\u3001P.1\u3001B.1.617.2\u3001Omicron\/B.1.1.529\u3001C.37\u3001B.1.621\u548cB.1.617.1\uff09\u7684RBD\u5177\u6709\u8f83\u9ad8\u7684\u4eb2\u548c\u529b\uff0c\u5bf9\u9664B.1.621\u4e4b\u5916\u7684\u5176\u4ed68\u79cd\u6bd2\u682a\u5747\u6709\u8f83\u9ad8\u7684\u963b\u65ad\u6d3b\u6027\uff1b\u5c0f\u9f20\u4f53\u5185\u771f\u75c5\u6bd2\u836f\u6548\u5b66\u7814\u7a76\u663e\u793aBA-CovMab\u80fd\u6709\u6548\u9884\u9632\u548c\u6cbb\u7597Omicron BA.1\u548cBA.2\u611f\u67d3\uff0c\u663e\u8457\u964d\u4f4e\u52a8\u7269\u611f\u67d3\u6a21\u578b\u80ba\u90e8\u6d3b\u75c5\u6bd2\u6ef4\u5ea62\uff5e3.5 log<sub>10<\/sub>\uff08p&lt;0.005\uff09\uff0c\u57fa\u672c\u6e05\u9664\u80ba\u90e8\u75c5\u6bd2\uff0c\u4fdd\u62a4\u4f5c\u7528\u4f18\u5f02\u3002<\/p>\n<p><b>\u535a\u5b89\u751f\u7269\u4e13\u4e1a\u6280\u672f\u5e73\u53f0\u52a9\u529b\u65b0\u51a0\u6297\u4f53\u9ad8\u6548\u5f00\u53d1<\/b><\/p>\n<p>\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u7206\u53d1\u4e24\u5e74\u6709\u4f59\uff0c\u5c3d\u7ba1\u4e16\u754c\u5404\u56fd\u5df2\u5f00\u5c55\u5927\u8303\u56f4\u75ab\u82d7\u63a5\u79cd\uff0c\u4e5f\u6709\u591a\u6b3e\u6cbb\u7597\u836f\u7269\u6295\u5165\u4f7f\u7528\uff0c\u4f46\u75c5\u6bd2\u7684\u4e0d\u65ad\u53d8\u5f02\u524a\u5f31\u4e86\u75ab\u82d7\u7684\u4fdd\u62a4\u6548\u529b\u53ca\u836f\u7269\u7597\u6548\uff0c\u611f\u67d3\u7387\u4f9d\u65e7\u5c45\u9ad8\u4e0d\u4e0b\u3002\u5f53\u4e0b\u56fd\u5185\u5916\u4e3b\u8981\u6d41\u884c\u7684\u53d8\u5f02\u682aOmicron\u5177\u6709\u6781\u9ad8\u4f20\u67d3\u6027\uff0c\u4e0e\u4ee5\u5f80\u7684\u65b0\u51a0\u75c5\u6bd2\u7a81\u53d8\u682a\u76f8\u6bd4\uff0c\u5168\u7403\u73b0\u6709\u65b0\u51a0\u75ab\u82d7\u53ca\u7edd\u5927\u90e8\u5206\u6cbb\u7597\u7528\u4e2d\u548c\u6297\u4f53\u5bf9\u5176\u6291\u5236\u6548\u679c\u666e\u904d\u8f83\u5f31\uff0c\u751a\u81f3\u5b8c\u5168\u5931\u53bb\u4e2d\u548c\u4f5c\u7528\uff0c\u9762\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u6301\u7eed\u53d8\u5f02\uff0c\u5f00\u53d1\u5e7f\u8c31\u3001\u9ad8\u6548\u7684\u4e2d\u548c\u6297\u4f53\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u548c\u9884\u9632\u7ed9\u836f\u663e\u5f97\u5c24\u4e3a\u8feb\u5207\u3002<\/p>\n<p>\u535a\u5b89\u751f\u7269\u51ed\u501f\u81ea\u6709\u7684\u5168\u4eba\u6297\u4f53\u8f6c\u57fa\u56e0\u5c0f\u9f20\u53ca\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u5e73\u53f0\uff0c\u5feb\u901f\u5b8c\u6210\u4e2d\u548c\u6297\u4f53\u7b5b\u9009\u5e76\u9501\u5b9a\u6700\u4f18\u6297\u4f53BA-CovMab\uff0c\u8fd9\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u535a\u5b89\u751f\u7269\u9ad8\u6548\u7684\u65b0\u836f\u521b\u65b0\u80fd\u529b\u3002<\/p>\n<p>\u535a\u5b89\u751f\u7269\u7814\u53d1\u603b\u88c1\u517c\u9996\u5e2d\u8fd0\u8425\u5b98\u7aa6\u660c\u6797\u535a\u58eb\u8868\u793a\uff1a&quot;\u81ea2020\u5e74\u65b0\u51a0\u75ab\u60c5\u7206\u53d1\u4ee5\u6765\uff0c\u535a\u5b89\u751f\u7269\u5feb\u901f\u54cd\u5e94\u56fd\u5bb6\u53f7\u53ec\u3001\u79ef\u6781\u884c\u52a8\uff0c\u51ed\u501f\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5168\u4eba\u6297\u4f53\u8f6c\u57fa\u56e0\u5c0f\u9f20\u53ca\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u5e73\u53f0\uff0c\u5f00\u53d1\u548c\u7814\u5236\u65b0\u51a0\u75c5\u6bd2\u4e2d\u548c\u6297\u4f53\uff0c\u76f8\u5173\u79d1\u7814\u6210\u679c\u83b7\u5f97\u4e86\u6709\u5173\u90e8\u95e8\u548c\u4e13\u5bb6\u7684\u9ad8\u5ea6\u8bc4&nbsp;\u4ef7\u3002\u6839\u636eBA-CovMab\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u7684\u4f18\u5f02\u8868\u73b0\uff0c\u6211\u4eec\u5c06\u52a0\u5feb\u63a8\u52a8\u8fd9\u4e00\u836f\u7269\u7684\u4e34\u5e8a\u7814\u7a76\u548c\u5f00\u53d1\uff0c\u4ee5\u4fbf\u65e9\u65e5\u4e3a\u6211\u56fd\u65b0\u51a0\u80ba\u708e\u7684\u6cbb\u7597\u548c\u9884\u9632\u505a\u51fa\u7a81\u51fa\u8d21\u732e\u3002&quot;&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5bf9Omicron\u7b49\u5404\u79cd\u53d8\u5f02\u682a\u5c55\u793a\u9ad8\u6548\u4e2d\u548c\u80fd\u529b \u4e0a\u6d772022\u5e749\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u8fd1\u65e5\uff0c\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u63a7\u80a1\u5b50\u516c\u53f8\u535a\u5b89\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u6cbb\u7597\/\u9884\u9632\u65b0\u51a0\u75c5\u6bd2\u80ba\u708e\u7684\u5e7f\u8c31\u4e2d\u548c\u6297\u4f53\u2014\u2014BA-CovMab\u6ce8\u5c04\u6db2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002BA-CovMab\u5bf9\u4e8eD614G\u53caAlpha\u3001Beta\u3001Delta\u3001Omicron BA.1-BA.5\u7b4918\u79cd\u75c5\u6bd2\u53d8\u5f02\u682a\u5747\u5177\u6709\u5e7f\u8c31\u9ad8\u6548\u7684\u4e2d\u548c\u80fd\u529b\uff0c\u6709\u671b\u6210\u4e3a\u5e94\u5bf9\u65b0\u51a0\u75c5\u6bd2\u53d8\u5f02\u682a\u7684\u6709\u529b\u6b66\u5668\u3002 \u5bf9\u5404\u79cd\u53d8\u5f02\u682a\u5c55\u793a\u9ad8\u6548\u4e2d\u548c\u6d3b\u6027\uff0c\u5c0f\u9f20\u65b0\u51a0\u611f\u67d3\u6a21\u578b\u4e2d\u5c55\u73b0\u826f\u597d\u7597\u6548 \u4e25\u91cd\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u5f81\u51a0\u72b6\u75c5\u6bd22\uff08SARS-CoV-2\uff09\u9020\u6210\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u5927\u6d41\u884c\uff0c\u5bf9\u5168\u7403\u4eba\u6c11\u5065\u5eb7\u4ee5\u53ca\u7ecf\u6d4e\u5e26\u6765\u5de8\u5927\u5a01\u80c1\u3002BA-CovMab\u662f\u4e00\u6b3e\u91cd\u7ec4\u5168\u4eba\u6e90\u5355\u514b\u9686\u4e2d\u548c\u6297\u4f53\uff0c\u901a\u8fc7\u591a\u79cd\u53d8\u5f02\u682a\u7684\u8868\u9762\u523a\u7a81\u86cb\u767d\uff08Spike\uff09\/\u53d7\u4f53\u7ed3\u6784\u57df\uff08RBD\uff09\u86cb\u767d\u5e8f\u8d2f\u514d\u75ab\u548c\u5e8f\u8d2f\u7b5b\u9009\u83b7\u5f97\uff0c\u53ef\u7279\u5f02\u6027\u7ed3\u5408SARS-CoV-2\u75c5\u6bd2Spike\u86cb\u767d\u7684RBD\u533a\uff0c\u5e76\u80fd\u6709\u6548\u963b\u65ad\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u8868\u9762\u53d7\u4f53ACE2\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236SARS-CoV-2\u75c5\u6bd2\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u7684\u4fb5\u67d3\u3002\u51b7\u51bb\u7535\u955c\u7814\u7a76\u663e\u793aBA-CovMab\u7ed3\u5408\u5728RBD\u7684\u4fdd\u5b88\u8868\u4f4d\u4e0a\uff0c\u907f\u5f00\u4e86RBD\u4e2d\u7684\u5927\u591a\u6570\u7a81\u53d8\u654f\u611f\u4f4d\u70b9\uff0c\u53ef\u4ee5\u5e7f\u6cdb\u6709\u6548\u5730\u4e2d\u548cSARS-CoV-2\u5404\u79cd\u53d8\u4f53\uff0c\u4e14\u5927\u5927\u964d\u4f4e\u5bf9\u672a\u6765\u53d8\u4f53\u5931\u53bb\u4e2d\u548c\u6d3b\u6027\u7684\u98ce\u9669\u3002 BA-CovMab\u7684\u4e34\u5e8a\u524d\u836f\u6548\u5b66\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a\u4f53\u5916\u5047\u75c5\u6bd2\u4e2d\u548c\u6d3b\u6027\u7ed3\u679c\u8868\u660eBA-CovMab\u53ef\u9ad8\u6548\u3001\u5e7f\u8c31\u4e2d\u548c18\u79cdSARS-CoV-2\u53d8\u5f02\u682a\uff0c\u5bf9Omicron BA.1, BA.2, BA.2.12.1, BA.2.13, BA.2.75, BA.3, BA.4\u548cBA.5\u7684\u5047\u75c5\u6bd2\u4e2d\u548c\u6d3b\u6027IC50\u503c\u8fbe1.24\uff5e5.52 ng\/mL\uff1b\u771f\u75c5\u6bd2\u4e2d\u548c\u6d3b\u6027\u7814\u7a76\u7ed3\u679c\u8868\u660e\u5bf9Omicron BA.1\u548cBA.2\u53d8\u5f02\u682a\u4e2d\u548c\u6d3b\u6027\u4f18\u5f02\uff0cIC50\u503c\u5206\u522b\u4e3a53.20\u300118.17 ng\/mL\uff1bBA-CovMab\u5bf99\u79cd\u65b0\u51a0\u6bd2\u682a\uff08WT strain\u3001B.1.1.7\u3001B.1.351\u3001P.1\u3001B.1.617.2\u3001Omicron\/B.1.1.529\u3001C.37\u3001B.1.621\u548cB.1.617.1\uff09\u7684RBD\u5177\u6709\u8f83\u9ad8\u7684\u4eb2\u548c\u529b\uff0c\u5bf9\u9664B.1.621\u4e4b\u5916\u7684\u5176\u4ed68\u79cd\u6bd2\u682a\u5747\u6709\u8f83\u9ad8\u7684\u963b\u65ad\u6d3b\u6027\uff1b\u5c0f\u9f20\u4f53\u5185\u771f\u75c5\u6bd2\u836f\u6548\u5b66\u7814\u7a76\u663e\u793aBA-CovMab\u80fd\u6709\u6548\u9884\u9632\u548c\u6cbb\u7597Omicron BA.1\u548cBA.2\u611f\u67d3\uff0c\u663e\u8457\u964d\u4f4e\u52a8\u7269\u611f\u67d3\u6a21\u578b\u80ba\u90e8\u6d3b\u75c5\u6bd2\u6ef4\u5ea62\uff5e3.5 log10\uff08p&lt;0.005\uff09\uff0c\u57fa\u672c\u6e05\u9664\u80ba\u90e8\u75c5\u6bd2\uff0c\u4fdd\u62a4\u4f5c\u7528\u4f18\u5f02\u3002 \u535a\u5b89\u751f\u7269\u4e13\u4e1a\u6280\u672f\u5e73\u53f0\u52a9\u529b\u65b0\u51a0\u6297\u4f53\u9ad8\u6548\u5f00\u53d1 \u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u7206\u53d1\u4e24\u5e74\u6709\u4f59\uff0c\u5c3d\u7ba1\u4e16\u754c\u5404\u56fd\u5df2\u5f00\u5c55\u5927\u8303\u56f4\u75ab\u82d7\u63a5\u79cd\uff0c\u4e5f\u6709\u591a\u6b3e\u6cbb\u7597\u836f\u7269\u6295\u5165\u4f7f\u7528\uff0c\u4f46\u75c5\u6bd2\u7684\u4e0d\u65ad\u53d8\u5f02\u524a\u5f31\u4e86\u75ab\u82d7\u7684\u4fdd\u62a4\u6548\u529b\u53ca\u836f\u7269\u7597\u6548\uff0c\u611f\u67d3\u7387\u4f9d\u65e7\u5c45\u9ad8\u4e0d\u4e0b\u3002\u5f53\u4e0b\u56fd\u5185\u5916\u4e3b\u8981\u6d41\u884c\u7684\u53d8\u5f02\u682aOmicron\u5177\u6709\u6781\u9ad8\u4f20\u67d3\u6027\uff0c\u4e0e\u4ee5\u5f80\u7684\u65b0\u51a0\u75c5\u6bd2\u7a81\u53d8\u682a\u76f8\u6bd4\uff0c\u5168\u7403\u73b0\u6709\u65b0\u51a0\u75ab\u82d7\u53ca\u7edd\u5927\u90e8\u5206\u6cbb\u7597\u7528\u4e2d\u548c\u6297\u4f53\u5bf9\u5176\u6291\u5236\u6548\u679c\u666e\u904d\u8f83\u5f31\uff0c\u751a\u81f3\u5b8c\u5168\u5931\u53bb\u4e2d\u548c\u4f5c\u7528\uff0c\u9762\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u6301\u7eed\u53d8\u5f02\uff0c\u5f00\u53d1\u5e7f\u8c31\u3001\u9ad8\u6548\u7684\u4e2d\u548c\u6297\u4f53\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u548c\u9884\u9632\u7ed9\u836f\u663e\u5f97\u5c24\u4e3a\u8feb\u5207\u3002 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