{"id":79529,"date":"2022-09-10T13:30:00","date_gmt":"2022-09-10T06:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022091013300079529"},"modified":"2022-09-10T22:10:15","modified_gmt":"2022-09-10T14:10:15","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a82022%e5%b9%b4%e6%ac%a7%e6%b4%b2%e8%82%bf%e7%98%a4%e5%86%85%e7%a7%91%e5%ad%a6%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022091013300079529","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u57282022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u4e0a\u516c\u5e03\u6700\u65b0\u6570\u636e\uff0c\u5305\u62ec\u53e3\u5934\u62a5\u544a\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u4e00\u7ebf\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u7814\u7a76\u7ed3\u679c"},"content":{"rendered":"<p><p><i>\u5728\u5168\u7403<\/i><i>3<\/i><i>\u671f\u8bd5\u9a8c\u4e2d\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u5c55\u793a\u51fa\u5728\u603b\u751f\u5b58\u671f\u4e0a\u7684\u975e\u52a3\u6548\u6027\u7ed3\u679c\u548c\u6709\u5229\u7684\u5b89\u5168\u6027\u7279\u5f81<\/i><\/p>\n<p><i>\u66f4\u591a\u6d77\u62a5\u5c55\u793a\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u548c\u8054\u5408\u7528\u836f\u7684\u5e7f\u6cdb\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e2d\u56fd\u5317\u4eac\uff0c\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c14<\/span><span class=\"legendSpanClass\">2022\u5e749\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff1b\u4e0a\u4ea4\u6240\u4ee3\u7801\uff1a688235\uff09\u662f\u4e00\u5bb6\u7acb\u8db3\u4e8e\u79d1\u5b66\u7684\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u6297\u80bf\u7624\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\u3001\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u516c\u53f8\u4eca\u65e5\u5728\u5df4\u9ece\u4e3e\u884c\u76842022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08European Society for Medical Oncology, ESMO\uff09\u5927\u4f1a\u4e0a\u5206\u4eab\u4e86\u5176\u57fa\u77f3\u4ea7\u54c1PD-1\u6297\u4f53\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff08\u4e2d\u6587\u5546\u54c1\u540d\uff1a\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff09\u5b9e\u4f53\u7624\u5f00\u53d1\u9879\u76ee\u7684\u8fdb\u5c55\u3002<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4f5c\u4e3a\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u5168\u74033\u671fRATIONALE 301\u8bd5\u9a8c\u7ed3\u679c\u88ab\u63a5\u53d7\u4e3a\u6700\u65b0\u7684\u6458\u8981\uff08LBA36\uff09\uff0c\u5df2\u5728\u4eca\u65e5\u7684\u53e3\u5934\u62a5\u544a\u73af\u8282\u516c\u5e03\u3002\u57fa\u4e8e\u5bf9\u6765\u81ea\u4e9a\u6d32\u3001\u6b27\u6d32\u548c\u7f8e\u56fd\u7684674\u4f8b\u60a3\u8005\u7684\u6700\u7ec8\u5206\u6790\uff0cRATIONALE 301\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff1a\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u5c55\u793a\u51fa\u5728\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e0a\u7684\u975e\u52a3\u6548\u6027\u7ed3\u679c\u3002\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7684\u4e2d\u4f4dOS\u4e3a15.9\u4e2a\u6708\uff0c\u800c\u7d22\u62c9\u975e\u5c3c\u7684OS\u4e3a14.1\u4e2a\u6708\uff08HR\uff1a0.85 [95.003% CI: 0.712\uff0c1.019]\uff09\uff1b\u8bd5\u9a8c\u672a\u8fbe\u5230\u4f18\u6548\u7ed3\u679c\u3002OS\u6570\u636e\u5728\u6240\u6709\u9884\u5148\u8bbe\u5b9a\u7684\u4e9a\u7ec4\uff08\u5305\u62ec\u5730\u533a\u95f4\uff09\u663e\u793a\u51fa\u4e00\u81f4\u6027\u3002<\/p>\n<p>\u5728RATIONALE 301\u7814\u7a76\u4e2d\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5177\u6709\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0814.3% vs 5.4%\uff09\u548c\u66f4\u6301\u4e45\u7684\u7f13\u89e3\uff08\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4DoR\u5206\u522b\u4e3a36.1\u4e2a\u6708\u548c&nbsp;11.0\u4e2a\u6708\uff09\u3002\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5206\u522b\u4e3a2.1\u4e2a\u6708\u548c3.4\u4e2a\u6708\uff1bHR\uff1a1.11 [95% CI: 0.92, 1.33]\u3002<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u548c\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u3002\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8868\u73b0\u51fa\u76f8\u5bf9\u66f4\u6709\u5229\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u2265 3\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u548c\u5bfc\u81f4\u7ec8\u6b62\u6cbb\u7597\u7684AE\u53d1\u751f\u7387\u8f83\u4f4e\uff08\u5206\u522b\u4e3a48.2% vs 65.4%\u548c10.9% vs 18.5%\uff09\u3002\u5bfc\u81f4\u6b7b\u4ea1\u7684AE\u5728\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7ec4\uff084.4%\uff09\u548c\u7d22\u62c9\u975e\u5c3c\u7ec4\uff085.2%\uff09\u5747\u8f83\u4f4e\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u5b9e\u4f53\u7624\u9996\u5e2d\u533b\u5b66\u5b98Mark Lanasa\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a&quot;RATIONALE 301\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\u4e86\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u6301\u4e45\u7684\u603b\u751f\u5b58\u671f\u83b7\u76ca\uff0c\u6211\u4eec\u6b23\u559c\u5730\u770b\u5230\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u3002\u867d\u7136\u9776\u5411\u6cbb\u7597\u53ef\u80fd\u662f\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u91cd\u8981\u6cbb\u7597\u65b9\u5f0f\uff0c\u4f46\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7279\u5f81\u4ecd\u662f\u91cd\u8981\u8003\u91cf\u56e0\u7d20\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u5728ESMO\u5206\u4eab\u6570\u636e\uff0c\u5e76\u4e0e\u9886\u5148\u7684\u80bf\u7624\u5b66\u7814\u7a76\u8005\u8fdb\u884c\u4ea4\u6d41\uff0c\u5e2e\u52a9\u4ed6\u4eec\u4e86\u89e3\u767e\u6d4e\u795e\u5dde\u7684\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u5b9e\u4f53\u7624\u9886\u57df\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u3002&quot;<\/p>\n<p>\u9664RATIONALE 301\u7814\u7a763\u671f\u6700\u65b0\u7ed3\u679c\u5916\uff0c\u767e\u6d4e\u795e\u5dde\u6d77\u62a5\u5c55\u793a\u4e86\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u4e00\u98793\u671f\u8bd5\u9a8c\u4e2d\u7684\u9884\u5148\u8bbe\u5b9a\u7684\u4e9a\u7ec4\u4e4b\u95f4\u53d6\u5f97\u7f13\u89e3\u4e00\u81f4\u6027\uff1b\u540c\u65f6\uff0c\u5728\u4e00\u9879\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u548c\u6297TIGIT\u6297\u4f53\u6b27\u53f8\u73c0\u5229\u5355\u6297\u76841\u671f\u8bd5\u9a8c\u4e2d\uff0c\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u548c\u826f\u597d\u7684\u8010\u53d7\u6027\uff1a<\/p>\n<ul type=\"disc\">\n<li>1031P\u2013<b>RATIONALE 303 (NCT03358875)<\/b>\uff1a\u5728\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u591a\u897f\u4ed6\u8d5b\u4f5c\u4e3a\u65e2\u5f80\u7ecf\u6cbb\u5c40\u90e8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u7684RATIONALE 303\u7814\u7a76\u4e2d\uff0c\u5728\u6240\u6709\u4e9a\u7ec4\u4e2d\uff0c\u5bf9\u4e9a\u6d32\u60a3\u8005\u4e0e\u975e\u4e9a\u6d32\u60a3\u8005\u8fdb\u884c\u9884\u5148\u8bbe\u5b9a\u7684\u5206\u6790\u663e\u793a\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u76f8\u6bd4\u591a\u897f\u4ed6\u8d5b\u5728OS\u3001PFS\u3001DoR\u548cORR\u4e0a\u5747\u6709\u66f4\u4f73\u8868\u73b0\u3002\u66ff\u96f7\u5229\u73e0\u5355\u6297\u62a5\u544a\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4f4e\u4e8e\u591a\u897f\u4ed6\u8d5b\uff08\u4e9a\u6d32\u60a3\u8005\u5206\u522b\u4e3a41.1% vs 75.2%\uff0c\u975e\u4e9a\u6d32\u60a3\u8005\u5206\u522b\u4e3a45.9% vs 72.9%\uff09\u3002<\/li>\n<li>1017P\u2013<b>AdvanTIG-105 (NCT04047862)<\/b>\uff1a\u5728\u8be51b\u671f\u5242\u91cf\u6269\u5c55\u7814\u7a76\u7684\u961f\u52171\u548c\u961f\u52172\u4e2d\uff0c\u6b27\u53f8\u73c0\u5229\u5355\u6297\u548c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\uff0c2\u671f\u63a8\u8350\u5242\u91cf\u5728\u8f6c\u79fb\u6027\u9cde\u72b6\u548c\u975e\u9cde\u72b6NSCLC\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002<\/li>\n<\/ul>\n<p>\u767e\u6d4e\u795e\u5dde\u6d77\u62a5\u5c55\u793a\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\uff1a<\/p>\n<ul type=\"disc\">\n<li>1194TiP \u2013 <b>AdvanTIG-205 (NCT05014815)<\/b><b>\uff1a<\/b>\u6b27\u53f8\u73c0\u5229\u5355\u6297\u548c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\uff0c\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u76842\u671f\u8bd5\u9a8c\u3002<\/li>\n<li>1187TiP \u2013 <b>BGB-A317-Sitra-301 (NCT04921358)<\/b>\uff1a\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u53f8\u66f2\u66ff\u5c3c\u5bf9\u6bd4\u5316\u7597\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u5316\u7597\u548c\u6297\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d-1\/\u914d\u4f531\u6297\u4f53\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u76843\u671f\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u66ff\u96f7\u5229\u73e0\u5355\u6297<\/b><\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff08\u4e2d\u6587\u5546\u54c1\u540d\uff1a\u767e\u6cfd\u5b89&reg;\uff09\u662f\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\uff0c\u8bbe\u8ba1\u76ee\u7684\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e0e\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\uff0c\u5e2e\u52a9\u4eba\u4f53\u514d\u75ab\u7ec6\u80de\u8bc6\u522b\u5e76\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0c\u5de8\u566c\u7ec6\u80de\u4e2d\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\u4e4b\u540e\u4f1a\u6fc0\u6d3b\u6297\u4f53\u4f9d\u8d56\u7ec6\u80de\u4ecb\u5bfc\u6740\u4f24T\u7ec6\u80de\uff0c\u4ece\u800c\u964d\u4f4e\u4e86PD-1\u6297\u4f53\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u662f\u7b2c\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u514d\u75ab\u80bf\u7624\u751f\u7269\u5e73\u53f0\u7814\u53d1\u7684\u836f\u7269\uff0c\u76ee\u524d\u6b63\u8fdb\u884c\u5355\u836f\u53ca\u8054\u5408\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u5f00\u53d1\u9488\u5bf9\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u80bf\u7624\u7684\u9002\u5e94\u75c7\u3002<\/p>\n<p>\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u5df2\u572830\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u5165\u7ec4\u8d85\u8fc711,000\u4f8b\u53d7\u8bd5\u8005\u3002<\/p>\n<p><b>\u5173\u4e8eRATIONALE 301<\/b><\/p>\n<p>RATIONALE 301\uff08NCT03412773\uff09\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6027\u7684\u5168\u74033\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\uff0c\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684HCC\u6210\u4eba\u60a3\u8005\u7684\u6548\u679c\u3002\u6b64\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u4e24\u4e2a\u6cbb\u7597\u7ec4\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u975e\u52a3\u6548\u6027\u6bd4\u8f83\u3002\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u662f\u76f2\u6001\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08BIRC\uff09\u6839\u636eRECIST 1.1\u7248\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u3002\u5176\u4ed6\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u6709\u6548\u6027\u8bc4\u4f30\uff08\u5982\u6839\u636eBIRC\u8bc4\u4f30\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3001\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u548c\u81f3\u75be\u75c5\u8fdb\u5c55\u65f6\u95f4\uff09\u548c\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\u6307\u6807\uff0c\u4ee5\u53ca\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u3002<\/p>\n<p><b>\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u7b2c\u4e00\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u53d1\u548c\u533b\u5b66\u4e8b\u52a1\u56e2\u961f\u5df2\u6709\u7ea63,300\u4eba\u4e14\u4ecd\u5728\u4e0d\u65ad\u58ee\u5927\u3002\u516c\u53f8\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301100\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u5c55\u5f00\uff0c\u5df2\u62db\u52df\u53d7\u8bd5\u8005\u8d85\u8fc716,000\u4eba\u3002\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u6df1\u539a\u3001\u8bd5\u9a8c\u5e03\u5c40\u5e7f\u6cdb\uff0c\u8bd5\u9a8c\u5df2\u8986\u76d6\u5168\u7403\u8d85\u8fc745\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\uff0c\u4e14\u5747\u7531\u516c\u53f8\u5185\u90e8\u56e2\u961f\u7275\u5934\u3002\u516c\u53f8\u6df1\u8015\u4e8e\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u7684\u9776\u5411\u6cbb\u7597\u53ca\u514d\u75ab\u6cbb\u7597\u7684\u5f00\u53d1\uff0c\u540c\u65f6\u4e13\u6ce8\u4e8e\u5355\u836f\u7597\u6cd5\u548c\u8054\u5408\u7597\u6cd5\u7684\u63a2\u7d22\u3002\u76ee\u524d\uff0c\u767e\u6d4e\u795e\u5dde\u81ea\u4e3b\u7814\u53d1\u7684\u4e09\u6b3e\u836f\u7269\u5df2\u83b7\u6279\u4e0a\u5e02\uff1a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08BTK\u6291\u5236\u5242\uff0c\u5df2\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6b27\u76df\u3001\u82f1\u56fd\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u5176\u4ed6\u56fd\u9645\u5e02\u573a\u83b7\u6279\u4e0a\u5e02\uff09\u3001\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u53ef\u6709\u6548\u907f\u514dFc-\u03b3\u53d7\u4f53\u7ed3\u5408\u7684\u6297PD-1\u6297\u4f53\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u53ca\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\uff08PARP\u6291\u5236\u5242\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff09\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u4e0e\u5176\u4ed6\u521b\u65b0\u516c\u53f8\u5408\u4f5c\uff0c\u5171\u540c\u643a\u624b\u63a8\u8fdb\u521b\u65b0\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u4ee5\u6ee1\u8db3\u5168\u7403\u5065\u5eb7\u9700\u6c42\u3002\u5728\u4e2d\u56fd\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u5bf9\u591a\u6b3e\u7531\u5b89\u8fdb\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u3001EUSA Pharma\u3001\u767e\u5965\u6cf0\u6388\u6743\u7684\u80bf\u7624\u836f\u7269\u8fdb\u884c\u5546\u4e1a\u5316\u3002\u516c\u53f8\u4e5f\u901a\u8fc7\u4e0e\u5305\u62ecMirati Therapeutics\u3001Seagen\u4ee5\u53caZymeworks\u5728\u5185\u7684\u591a\u5bb6\u516c\u53f8\u5408\u4f5c\uff0c\u66f4\u5927\u7a0b\u5ea6\u5730\u6ee1\u8db3\u5f53\u524d\u5168\u7403\u8303\u56f4\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002<\/p>\n<p>2021\u5e741\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u5ba3\u5e03\u8fbe\u6210\u5408\u4f5c\uff0c\u6388\u4e88\u8bfa\u534e\u5728\u5317\u7f8e\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u767e\u6d4e\u795e\u5dde\u6297PD-1\u6297\u4f53\u836f\u7269\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff09\u7684\u6743\u5229\u3002\u57fa\u4e8e\u8fd9\u4e00\u5353\u6709\u6210\u6548\u7684\u5408\u4f5c\uff0c\u767e\u6d4e\u795e\u5dde\u548c\u8bfa\u534e\u4e8e2021\u5e7412\u6708\u5ba3\u5e03\u4e86\u5173\u4e8e\u6b63\u57283\u671f\u5f00\u53d1\u7684TIGIT\u6291\u5236\u5242\u6b27\u53f8\u73c0\u5229\u5355\u6297\u7684\u9009\u62e9\u6743\u3001\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002\u8bfa\u534e\u548c\u767e\u6d4e\u795e\u5dde\u8fd8\u7b7e\u8ba2\u4e86\u4e00\u9879\u6218\u7565\u5546\u4e1a\u534f\u8bae\uff0c\u6839\u636e\u8be5\u534f\u8bae\uff0c\u767e\u6d4e\u795e\u5dde\u5c06\u5728\u4e2d\u56fd\u6307\u5b9a\u533a\u57df\u63a8\u5e7f5\u6b3e\u5df2\u83b7\u6279\u7684\u8bfa\u534e\u80bf\u7624\u4ea7\u54c1\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u3001\u53ef\u8d1f\u62c5\u7684\u6297\u80bf\u7624\u836f\u7269\uff0c\u65e8\u5728\u4e3a\u5168\u7403\u60a3\u8005\u6539\u5584\u6cbb\u7597\u6548\u679c\uff0c\u63d0\u9ad8\u836f\u7269\u53ef\u53ca\u6027\u3002\u901a\u8fc7\u5f3a\u5927\u7684\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u548c\u5916\u90e8\u6218\u7565\u5408\u4f5c\uff0c\u6211\u4eec\u4e0d\u65ad\u52a0\u901f\u5f00\u53d1\u591a\u5143\u3001\u521b\u65b0\u7684\u836f\u7269\u7ba1\u7ebf\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u66f4\u591a\u60a3\u8005\u5168\u9762\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u3002\u767e\u6d4e\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u8fc78,500\u4eba\u7684\u56e2\u961f\uff0c\u5e76\u5728\u4e2d\u56fd\u5317\u4eac\u3001\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u745e\u58eb\u5df4\u585e\u5c14\u8bbe\u7acb\u4e86\u4e3b\u8981\u529e\u4e8b\u5904\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.beigene.com.cn<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 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0.712\uff0c1.019]\uff09\uff1b\u8bd5\u9a8c\u672a\u8fbe\u5230\u4f18\u6548\u7ed3\u679c\u3002OS\u6570\u636e\u5728\u6240\u6709\u9884\u5148\u8bbe\u5b9a\u7684\u4e9a\u7ec4\uff08\u5305\u62ec\u5730\u533a\u95f4\uff09\u663e\u793a\u51fa\u4e00\u81f4\u6027\u3002 \u5728RATIONALE 301\u7814\u7a76\u4e2d\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5177\u6709\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0814.3% vs 5.4%\uff09\u548c\u66f4\u6301\u4e45\u7684\u7f13\u89e3\uff08\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4DoR\u5206\u522b\u4e3a36.1\u4e2a\u6708\u548c&nbsp;11.0\u4e2a\u6708\uff09\u3002\u66ff\u96f7\u5229\u73e0\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5206\u522b\u4e3a2.1\u4e2a\u6708\u548c3.4\u4e2a\u6708\uff1bHR\uff1a1.11 [95% CI: 0.92, 1.33]\u3002 \u66ff\u96f7\u5229\u73e0\u5355\u6297\u548c\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u3002\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8868\u73b0\u51fa\u76f8\u5bf9\u66f4\u6709\u5229\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u2265 3\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u548c\u5bfc\u81f4\u7ec8\u6b62\u6cbb\u7597\u7684AE\u53d1\u751f\u7387\u8f83\u4f4e\uff08\u5206\u522b\u4e3a48.2% vs 65.4%\u548c10.9% vs 18.5%\uff09\u3002\u5bfc\u81f4\u6b7b\u4ea1\u7684AE\u5728\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7ec4\uff084.4%\uff09\u548c\u7d22\u62c9\u975e\u5c3c\u7ec4\uff085.2%\uff09\u5747\u8f83\u4f4e\u3002 \u767e\u6d4e\u795e\u5dde\u5b9e\u4f53\u7624\u9996\u5e2d\u533b\u5b66\u5b98Mark Lanasa\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a&quot;RATIONALE 301\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\u4e86\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u6301\u4e45\u7684\u603b\u751f\u5b58\u671f\u83b7\u76ca\uff0c\u6211\u4eec\u6b23\u559c\u5730\u770b\u5230\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u3002\u867d\u7136\u9776\u5411\u6cbb\u7597\u53ef\u80fd\u662f\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u91cd\u8981\u6cbb\u7597\u65b9\u5f0f\uff0c\u4f46\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7279\u5f81\u4ecd\u662f\u91cd\u8981\u8003\u91cf\u56e0\u7d20\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u5728ESMO\u5206\u4eab\u6570\u636e\uff0c\u5e76\u4e0e\u9886\u5148\u7684\u80bf\u7624\u5b66\u7814\u7a76\u8005\u8fdb\u884c\u4ea4\u6d41\uff0c\u5e2e\u52a9\u4ed6\u4eec\u4e86\u89e3\u767e\u6d4e\u795e\u5dde\u7684\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u5b9e\u4f53\u7624\u9886\u57df\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u3002&quot; \u9664RATIONALE 301\u7814\u7a763\u671f\u6700\u65b0\u7ed3\u679c\u5916\uff0c\u767e\u6d4e\u795e\u5dde\u6d77\u62a5\u5c55\u793a\u4e86\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5728\u4e00\u98793\u671f\u8bd5\u9a8c\u4e2d\u7684\u9884\u5148\u8bbe\u5b9a\u7684\u4e9a\u7ec4\u4e4b\u95f4\u53d6\u5f97\u7f13\u89e3\u4e00\u81f4\u6027\uff1b\u540c\u65f6\uff0c\u5728\u4e00\u9879\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u548c\u6297TIGIT\u6297\u4f53\u6b27\u53f8\u73c0\u5229\u5355\u6297\u76841\u671f\u8bd5\u9a8c\u4e2d\uff0c\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u548c\u826f\u597d\u7684\u8010\u53d7\u6027\uff1a 1031P\u2013RATIONALE 303 (NCT03358875)\uff1a\u5728\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5bf9\u6bd4\u591a\u897f\u4ed6\u8d5b\u4f5c\u4e3a\u65e2\u5f80\u7ecf\u6cbb\u5c40\u90e8\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u7684RATIONALE 303\u7814\u7a76\u4e2d\uff0c\u5728\u6240\u6709\u4e9a\u7ec4\u4e2d\uff0c\u5bf9\u4e9a\u6d32\u60a3\u8005\u4e0e\u975e\u4e9a\u6d32\u60a3\u8005\u8fdb\u884c\u9884\u5148\u8bbe\u5b9a\u7684\u5206\u6790\u663e\u793a\uff0c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u76f8\u6bd4\u591a\u897f\u4ed6\u8d5b\u5728OS\u3001PFS\u3001DoR\u548cORR\u4e0a\u5747\u6709\u66f4\u4f73\u8868\u73b0\u3002\u66ff\u96f7\u5229\u73e0\u5355\u6297\u62a5\u544a\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4f4e\u4e8e\u591a\u897f\u4ed6\u8d5b\uff08\u4e9a\u6d32\u60a3\u8005\u5206\u522b\u4e3a41.1% vs 75.2%\uff0c\u975e\u4e9a\u6d32\u60a3\u8005\u5206\u522b\u4e3a45.9% vs 72.9%\uff09\u3002 1017P\u2013AdvanTIG-105 (NCT04047862)\uff1a\u5728\u8be51b\u671f\u5242\u91cf\u6269\u5c55\u7814\u7a76\u7684\u961f\u52171\u548c\u961f\u52172\u4e2d\uff0c\u6b27\u53f8\u73c0\u5229\u5355\u6297\u548c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\uff0c2\u671f\u63a8\u8350\u5242\u91cf\u5728\u8f6c\u79fb\u6027\u9cde\u72b6\u548c\u975e\u9cde\u72b6NSCLC\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002 \u767e\u6d4e\u795e\u5dde\u6d77\u62a5\u5c55\u793a\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\uff1a 1194TiP \u2013 AdvanTIG-205 (NCT05014815)\uff1a\u6b27\u53f8\u73c0\u5229\u5355\u6297\u548c\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\uff0c\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u76842\u671f\u8bd5\u9a8c\u3002 1187TiP \u2013 BGB-A317-Sitra-301 (NCT04921358)\uff1a\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u53f8\u66f2\u66ff\u5c3c\u5bf9\u6bd4\u5316\u7597\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u5316\u7597\u548c\u6297\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d-1\/\u914d\u4f531\u6297\u4f53\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\/\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u76843\u671f\u7814\u7a76\u3002&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2022091013300079529\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-79529","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/79529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=79529"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/79529\/revisions"}],"predecessor-version":[{"id":79530,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/79529\/revisions\/79530"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=79529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=79529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=79529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}