{"id":78713,"date":"2022-09-05T07:00:00","date_gmt":"2022-09-05T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022090507000078713"},"modified":"2022-09-05T22:14:21","modified_gmt":"2022-09-05T14:14:21","slug":"%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83mazdutide%ef%bc%88ibi362%ef%bc%89%e5%9c%a8%e4%b8%ad%e5%9b%bd%e8%82%a5%e8%83%96%e5%8f%97%e8%af%95%e8%80%85%e4%b8%ad%e7%9a%84ii%e6%9c%9f%e4%b8%b4","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022090507000078713","title":{"rendered":"\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03mazdutide\uff08IBI362\uff09\u5728\u4e2d\u56fd\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u9ad8\u5242\u91cf\u961f\u5217\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f"},"content":{"rendered":"

\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde<\/span>2022\u5e749\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u91cd\u6fc0\u52a8\u5242mazdutide\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI362\uff09\u5728\u4e2d\u56fd\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u9ad8\u5242\u91cf\uff089.0 mg\uff09\u961f\u5217\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f\u3002<\/p>\n

\u672c\u7814\u7a76\uff08ClinicalTrials.gov, NCT04904913\uff09\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30mazdutide\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u4f4e\u5242\u91cf\u961f\u5217\uff083.0 mg\u30014.5 mg\u548c6.0 mg\uff09\u7ed3\u679c\u5df2\u4e8e\u4eca\u5e746\u6708\u62ab\u9732\uff0c\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002\u7b2c24\u5468\u65f6\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cmazdutide\u5404\u5242\u91cf\u5747\u5c55\u73b0\u51fa\u663e\u8457\u7684\u51cf\u91cd\u7597\u6548\uff0c\u4e14\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u5e76\u80fd\u4e3a\u53d7\u8bd5\u8005\u5e26\u6765\u591a\u91cd\u5fc3\u8840\u7ba1\u4ee3\u8c22\u83b7\u76ca\uff1b\u540c\u65f6\uff0cmazdutide\u8010\u53d7\u6027\u826f\u597d\uff0c\u6574\u4f53\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u540c\u7c7b\u836f\u7269\u76f8\u4f3c\u3002\u6b64\u5916\uff0c\u5728Ib\u671f\u7814\u7a76\uff08ClinicalTrials.gov, NCT04440345\uff09\u4e2d\uff0cmazdutide\u6ef4\u5b9a\u81f39 mg\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u548c\u4f18\u4e8e\u4f4e\u5242\u91cf\u7ec4\u7684\u7597\u6548\uff0c\u7528\u836f12\u5468\u540e\uff0c\u4f53\u91cd\u964d\u5e45\u53ef\u8fbe11.7%\u3002\u57fa\u4e8e\u4ee5\u4e0a\u7ed3\u679c\uff0c\u7533\u529e\u65b9\u5728\u80a5\u80d6\u60a3\u8005\uff08BMI\u226530 kg\/m2<\/sup>\uff09\u4e2d\u5f00\u5c55mazdutide\u9ad8\u5242\u91cf\uff089.0 mg\uff09\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7814\u7a76\u30029.0 mg\u961f\u5217\u8ba1\u5212\u7eb3\u516580\u4f8b\u53d7\u8bd5\u8005\uff0c\u63093\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7mazdutide 9.0 mg\u6216\u5b89\u6170\u5242\u6cbb\u759724\u5468\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u7b2c24\u5468\u65f6\u53d7\u8bd5\u8005\u4f53\u91cd\u76f8\u5bf9\u57fa\u7ebf\u7684\u767e\u5206\u6bd4\u53d8\u5316\u3002<\/p>\n

\u672c\u9879\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u7eaa\u7acb\u519c\u6559\u6388<\/b>\u8868\u793a\uff1a\u201c\u80a5\u80d6\u4e0e\u591a\u79cd\u6162\u6027\u975e\u4f20\u67d3\u6027\u75be\u75c5\u76f8\u5173\uff0c\u88ab\u5217\u4e3a\u5f71\u54cd\u5168\u4eba\u7c7b\u75be\u75c5\u8d1f\u62c5\u7684\u91cd\u8981\u5371\u9669\u56e0\u7d20\u4e4b\u4e00\u3002\u4e2d\u56fd\u80a5\u80d6\u75c7\u7684\u60a3\u75c5\u4eba\u6570\u548c\u589e\u957f\u901f\u5ea6\u5747\u5c45\u4e16\u754c\u9996\u4f4d[1]<\/sup>\uff0c\u8feb\u5207\u9700\u8981\u6709\u6548\u4e14\u5b89\u5168\u7684\u51cf\u91cd\u836f\u7269\u6ee1\u8db3\u4e34\u5e8a\u75be\u75c5\u9632\u6cbb\u9700\u6c42\u3002Mazdutide\u4f5c\u4e3aGLP-1R\/GCGR\u53cc\u91cd\u6fc0\u52a8\u5242\uff0c\u5728\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u7fa4\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u5c55\u793a\u51fa\u663e\u8457\u7684\u51cf\u91cd\u7597\u6548\u53ca\u7efc\u5408\u4ee3\u8c22\u6539\u5584\u6548\u679c\u3002II\u671f\u7814\u7a76\u4f4e\u5242\u91cf\u961f\u5217\u7684\u7ed3\u679c\u8868\u660e\uff0cmazdutide 6.0 mg\u6cbb\u7597\u534a\u5e74\u5373\u53ef\u4e3a\u60a3\u8005\u5e26\u676511.6%\u7684\u4f53\u91cd\u964d\u5e45\uff0c\u8bf4\u660e\u5176\u5177\u6709\u6210\u4e3a\u5168\u7403\u8303\u56f4\u5185\u540c\u7c7b\u6700\u4f18\u836f\u7269\u7684\u6f5c\u529b\u3002\u6211\u6709\u4fe1\u5fc3mazdutide 9.0mg\u80fd\u591f\u5728\u80a5\u80d6\u4eba\u7fa4\u4e2d\u5c55\u73b0\u51fa\u66f4\u7a81\u51fa\u7684\u51cf\u91cd\u7597\u6548\uff0c\u4e3a\u4e2d\u5ea6\u548c\u91cd\u5ea6\u80a5\u80d6\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n

\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u4e34\u5e8a\u5f00\u53d1\u526f\u603b\u88c1\u94b1\u956d\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201c\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u7fa4\u7684II\u671f\u7814\u7a76\u4e2d\uff0c\u4f4e\u5242\u91cfmazdutide\u5373\u5c55\u793a\u51fa\u5f3a\u5927\u7684\u51cf\u91cd\u7597\u6548\u4ee5\u53ca\u6539\u5584\u4ee3\u8c22\u6307\u6807\u7684\u591a\u91cd\u83b7\u76ca\uff0c\u4f53\u73b0\u51famazdutide\u5728GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7c7b\u836f\u7269\u4e2d\u7684\u6700\u4f18\u6f5c\u529b\u3002\u4e3a\u8fdb\u4e00\u6b65\u6316\u6398\u5176\u5de8\u5927\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\uff0c\u6211\u4eec\u8ba1\u5212\u5728BMI\u226530 kg\/m2<\/sup>\u7684\u80a5\u80d6\u60a3\u8005\u4e2d\u7ee7\u7eed\u63a2\u7d22\u9ad8\u5242\u91cfmazdutide 9.0 mg\u7684\u4e34\u5e8a\u83b7\u76ca\u3002\u5df2\u5b8c\u6210\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793amazdutide\u662f\u76ee\u524d\u5df2\u4e0a\u5e02\u6216\u5728\u7814\u51cf\u91cd\u5355\u836f\u4e2d\u552f\u4e00\u5728\u7ed9\u836f12\u5468\u65f6\uff0c\u51cf\u91cd\u5e45\u5ea6\u5373\u8d85\u8fc711.5%\u7684\u5355\u836f\u3002\u6211\u4eec\u5e0c\u671b\u901a\u8fc7\u7ee7\u7eed\u63a8\u8fdb\u66f4\u9ad8\u5242\u91cf\u7684\u7814\u7a76\uff0c\u4e3a\u80a5\u80d6\u60a3\u8005\u5e26\u6765\u80fd\u4e0e\u51cf\u91cd\u624b\u672f\u7597\u6548\u76f8\u5ab2\u7f8e\uff0c\u4e14\u5b89\u5168\u66f4\u53ef\u53ca\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n

\u5173\u4e8e\u80a5\u80d6<\/b><\/p>\n

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\u5173\u4e8e<\/b>Mazdutide\uff08IBI362\uff09<\/b><\/p>\n

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\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n

\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n

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\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001\u8d5b\u8bfa\u83f2\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n

\u58f0\u660e\uff1a<\/p>\n

1. \u8be5\u9002\u5e94\u75c7\u4e3a\u7814\u7a76\u4e2d\u7684\u836f\u54c1\u7528\u6cd5\uff0c\u5c1a\u672a\u5728\u4e2d\u56fd\u83b7\u6279\uff1b<\/i><\/p>\n

2. \u4fe1\u8fbe\u4e0d\u63a8\u8350\u4efb\u4f55\u672a\u83b7\u6279\u7684\u836f\u54c1\/\u9002\u5e94\u75c7\u4f7f\u7528\u3002<\/i><\/p>\n

\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n

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\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n

\n\n\n\n
\n

[1]<\/sup>\u57fa\u4e8e\u4e34\u5e8a\u7684\u80a5\u80d6\u75c7\u591a\u5b66\u79d1\u8bca\u7597\u5171\u8bc6(2021\u5e74\u7248).\u4e2d\u534e\u5185\u5206\u6ccc\u4ee3\u8c22\u6742\u5fd7, 2021,37(11) : 959-972<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u56fd\u7f57\u514b\u7ef4\u5c14\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e749\u67085\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u80bf\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\uff08glucagon receptor, GCGR\uff09\u53cc\u91cd\u6fc0\u52a8\u5242mazdutide\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI362\uff09\u5728\u4e2d\u56fd\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u9ad8\u5242\u91cf\uff089.0 mg\uff09\u961f\u5217\u5b8c\u6210\u9996\u4f8b\u53d7\u8bd5\u8005\u7ed9\u836f\u3002 \u672c\u7814\u7a76\uff08ClinicalTrials.gov, NCT04904913\uff09\u662f\u4e00\u9879\u5728\u4e2d\u56fd\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u8bc4\u4f30mazdutide\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u4f4e\u5242\u91cf\u961f\u5217\uff083.0 mg\u30014.5 mg\u548c6.0 mg\uff09\u7ed3\u679c\u5df2\u4e8e\u4eca\u5e746\u6708\u62ab\u9732\uff0c\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002\u7b2c24\u5468\u65f6\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cmazdutide\u5404\u5242\u91cf\u5747\u5c55\u73b0\u51fa\u663e\u8457\u7684\u51cf\u91cd\u7597\u6548\uff0c\u4e14\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u5e76\u80fd\u4e3a\u53d7\u8bd5\u8005\u5e26\u6765\u591a\u91cd\u5fc3\u8840\u7ba1\u4ee3\u8c22\u83b7\u76ca\uff1b\u540c\u65f6\uff0cmazdutide\u8010\u53d7\u6027\u826f\u597d\uff0c\u6574\u4f53\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u540c\u7c7b\u836f\u7269\u76f8\u4f3c\u3002\u6b64\u5916\uff0c\u5728Ib\u671f\u7814\u7a76\uff08ClinicalTrials.gov, NCT04440345\uff09\u4e2d\uff0cmazdutide\u6ef4\u5b9a\u81f39 mg\u5c55\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u548c\u4f18\u4e8e\u4f4e\u5242\u91cf\u7ec4\u7684\u7597\u6548\uff0c\u7528\u836f12\u5468\u540e\uff0c\u4f53\u91cd\u964d\u5e45\u53ef\u8fbe11.7%\u3002\u57fa\u4e8e\u4ee5\u4e0a\u7ed3\u679c\uff0c\u7533\u529e\u65b9\u5728\u80a5\u80d6\u60a3\u8005\uff08BMI\u226530 kg\/m2\uff09\u4e2d\u5f00\u5c55mazdutide\u9ad8\u5242\u91cf\uff089.0 mg\uff09\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7814\u7a76\u30029.0 mg\u961f\u5217\u8ba1\u5212\u7eb3\u516580\u4f8b\u53d7\u8bd5\u8005\uff0c\u63093\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7mazdutide 9.0 mg\u6216\u5b89\u6170\u5242\u6cbb\u759724\u5468\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u7b2c24\u5468\u65f6\u53d7\u8bd5\u8005\u4f53\u91cd\u76f8\u5bf9\u57fa\u7ebf\u7684\u767e\u5206\u6bd4\u53d8\u5316\u3002 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