{"id":77996,"date":"2022-08-31T10:38:00","date_gmt":"2022-08-31T03:38:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022083110380077996"},"modified":"2022-08-31T22:11:32","modified_gmt":"2022-08-31T14:11:32","slug":"%e5%a4%a9%e6%bc%94%e8%8d%af%e4%b8%9a%e5%85%ac%e5%b8%832022%e5%b9%b4%e4%b8%8a%e5%8d%8a%e5%b9%b4%e8%b4%a2%e5%8a%a1%e4%b8%9a%e7%bb%a9%e5%8f%8a%e5%85%ac%e5%8f%b8%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022083110380077996","title":{"rendered":"\u5929\u6f14\u836f\u4e1a\u516c\u5e032022\u5e74\u4e0a\u534a\u5e74\u8d22\u52a1\u4e1a\u7ee9\u53ca\u516c\u53f8\u8fdb\u5c55"},"content":{"rendered":"<p class=\"prntac\"><i>&#8211; <\/i><i>\u6297<\/i><i>CTLA-4 <\/i><i>\u65b0\u8868\u4f4d\u6297\u4f53<\/i><i>&nbsp;ADG116<\/i><i>\u7684\u5173\u952e\u65b0\u6570\u636e\uff0c\u8be5\u6297\u4f53\u5728\u5355\u4e00\u7597\u6cd5\u4ee5\u53ca\u4e0e\u6297<\/i><i>&nbsp;PD-1<\/i><i>\u7684\u8054\u5408\u7597\u6cd5\u4e2d\u5c55\u73b0\u51fa\u5f15\u4eba\u6ce8\u76ee\u7684\u5b89\u5168\u6027\u53ca\u80bf\u7624\u5b8c\u5168\u548c\u90e8\u5206\u6536\u7f29\u7684\u4e34\u5e8a\u7597\u6548\uff1b\u76f8\u5173\u6570\u636e\u5c06\u5728<\/i><i>2022<\/i><i>\u5e74\u7f8e\u56fd\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a\uff08<\/i><i>SITC<\/i><i>\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03<\/i> <i>\u2013<\/i><\/p>\n<p class=\"prntac\">&#8211; <i>\u6297<\/i><i>CTLA-4\u63a9\u853d<\/i><i>\u5b89\u5168<\/i><i>\u6297\u4f53<\/i><i>ADG126\u4f5c\u4e3a\u5355\u4e00\u836f\u7269\u591a\u6b21\u91cd\u590d\u7ed9\u836f\u6700\u5927\u5242\u91cf\u8fbe\u523020 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type=\"disc\">\n<li>\u5728\u5355\u4e00\u6cbb\u7597\u4ee5\u53ca\u4e0e\u6297PD-1\u836f\u7269\u7684\u8054\u5408\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u60ca\u8273\u7684\u7597\u6548\uff1a<\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; \u9488\u5bf9\u4e00\u4e2a\u73b0\u6709\u6297CTLA-4\u7597\u6cd5\u5c1a\u672a\u83b7\u6279\u7684\u80bf\u7624\u7c7b\u578b\uff0c\u91c7\u53d6ADG116\u5355\u4e00\u7597\u6cd5\u540e\u89c2\u5bdf\u5230\u4e00\u4f8b\u75c5\u4eba\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u9488\u5bf9\u4e00\u4e2a\u73b0\u6709\u6297CTLA-4\u7597\u6cd5\u5c1a\u672a\u83b7\u6279\u7684\u80bf\u7624\u7c7b\u578b\uff0c\u91c7\u53d6ADG116\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u5e76\u91cd\u590d\u7ed9\u836f\u540e\u89c2\u5bdf\u5230\u4e00\u4f8b\u75c5\u4eba\u5df2\u786e\u8ba4\u83b7\u5f97\u5feb\u901f\u7684\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u8ba1\u5212\u4e8e2022\u5e7411\u67088\u65e5\u81f312\u65e5\u5728\u6ce2\u58eb\u987f\u53ec\u5f00\u7684\u7b2c37\u5c4a\u7f8e\u56fd\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a\uff08SITC\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u672c\u9879Ib\/II\u671f\u8bd5\u9a8c\u7684\u6570\u636e\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u8003\u8651\u5230\u7ade\u4e89\u56e0\u7d20\uff0c\u5929\u6f14\u76ee\u524d\u5e76\u672a\u900f\u9732\u4e0e\u8fd9\u4e9b\u5ba2\u89c2\u7f13\u89e3\u6548\u679c\u6709\u5173\u7684\u5242\u91cf\u6216\u80bf\u7624\u7c7b\u578b\u4fe1\u606f\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5728\u5355\u4e00\u7597\u6cd5\u4ee5\u53ca\u4e0e\u6297PD-1\u836f\u7269\u7684\u8054\u5408\u7597\u6cd5\u4e2d\u8868\u73b0\u51fa\u5f15\u4eba\u6ce8\u76ee\u7684\u5b89\u5168\u6027\uff1a<\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; ADG116\u5355\u4e00\u7597\u6cd5\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u5df2\u5b8c\u6210\uff0c\u5171\u8ba1\u7ed9\u836f30\u540d\u60a3\u8005\uff0c\u6700\u9ad8\u5242\u91cf\u8fbe\u523015 mg\/kg\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u5e76\u91cd\u590d\u7ed9\u836f\u300210 mg\/kg\u7684\u5242\u91cf\u6269\u5c55\u8bd5\u9a8c\u7ee7\u7eed\u62db\u52df\u53c2\u4e0e\u60a3\u8005\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u59822021\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u514d\u75ab\u80bf\u7624\u5b66\u5927\u4f1a\uff08<a href=\"https:\/\/adagene-www.s3.us-west-2.amazonaws.com\/pdf\/ADG116_ESMO-IO_2021.pdf\" target=\"_blank\" rel=\"nofollow noopener\">ESMO-IO<\/a>\uff09\u7684\u6d77\u62a5\u6240\u793a\uff0c10 mg\/kg\u5242\u91cf\u6c34\u5e73\u7684\u7ed9\u836f\u6cbb\u7597\u4e2d\uff0c\u4ec5\u89c2\u5bdf\u5230\u4e00\u4f8b\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u4e8b\u4ef6\u3002\u622a\u81f3\u64b0\u7a3f\u65e5\uff0c ADG116\u5355\u4e00\u7597\u6cd5\u8bd5\u9a8c\u4e2d\u672a\u89c2\u5bdf\u5230\u65b0\u589e\u6216\u8fdf\u53d1\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u5176\u4e2d\u5305\u62ec\u5df2\u63a5\u53d7\u56db\u8f6e\u4ee5\u4e0a\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u5b89\u5168\u5ba1\u67e5\u59d4\u5458\u4f1a\u6700\u8fd1\u6279\u51c6\u542f\u52a8ADG116 3 mg\/kg \u5242\u91cf\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u8054\u5408\u7528\u836f\u7684\u5242\u91cf\u6269\u5c55\u3002<\/p>\n<ul type=\"disc\">\n<li>\u7ee7\u7eed\u63a8\u8fdb\u4e0e\u6297PD-1\u548c\u4e0e\u6297CD137\u836f\u7269\u7684\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c<\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; ADG116\u4e0e\u6297PD-1\u6297\u4f53\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\uff08ADG116-P001 \/ KEYNOTE-C97\uff09\u5373\u5c06\u5b8c\u6210\u3002\u6b64\u6b21Ib\/II\u671f\u8bd5\u9a8c\u7684\u6570\u636e\u5c06\u57282022\u5e74SITC\u4e0a\u5c55\u793a\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u6b63\u5728\u8bc4\u4f30ADG116\u4e0e\u6297CD137\u6297\u4f53ADG106\u8054\u5408\u7597\u6cd5\uff0c\u4f18\u5316\u8be5\u9879\u521b\u65b0\u72ec\u6709\u7684\u8054\u5408\u7597\u6cd5\u7684\u7ec4\u5408\u5242\u91cf\u4e0e\u7ed9\u836f\u5468\u671f\u3002\u5929\u6f14\u76ee\u524d\u4e3a\u4e34\u5e8a\u63a2\u7d22\u9776\u5411CTLA-4\u4e0eCD137\u53cc\u901a\u8def\u534f\u540c\u6548\u5e94\u7684\u5168\u7403\u9886\u8dd1\u8005\uff0c\u5bf9\u4e8e\u6b64\u79cd\u5f3a\u529b\u7ec4\u5408<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3085474\/\" target=\"_blank\" rel=\"nofollow noopener\">\u5df2\u6709\u4ee4\u4eba\u4fe1\u670d\u7684\u7684\u4e34\u5e8a\u524d\u8bba\u8bc1<\/a>\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u4e3a\u5728\u4e2d\u56fd\u7684\u8054\u5408\u8bd5\u9a8c\u505a\u597d\u51c6\u5907\uff0c\u8bc4\u4f30ADG116\u5355\u4e00\u7597\u6cd5\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG116-1002\uff09\u5df2\u5242\u91cf\u9012\u589e\u523010 mg\/kg\u3002\u6297CTLA-4\u548c\u6297PD-1\u836f\u7269\u7684\u8054\u5408\u7597\u6cd5\u76ee\u524d\u5728\u4e2d\u56fd\u4ec5\u83b7\u51c6\u7528\u4e8e\u6cbb\u7597\u4e00\u6b3e\u80bf\u7624\u7c7b\u578b\uff0c\u56e0\u6b64\u8574\u85cf\u5de8\u5927\u7684\u4e34\u5e8a\u53ca\u5e02\u573a\u9700\u6c42\u3002<\/p>\n<p><b>ADG<\/b><b>126<\/b><b>\uff08\u91c7\u7528\u7cbe\u51c6\u63a9\u853d\u6280\u672f\uff0c\u9776\u5411\u72ec\u7279\u8868\u4f4d\u7684\u6297<\/b><b>CTLA-4<\/b><b>\u5b89\u5168\u6297\u4f53<\/b><b>SAFEbody&reg;<\/b><b>\uff09<\/b><\/p>\n<ul type=\"disc\">\n<li><b><i>\u5728\u524d\u6240\u672a\u6709\u7684\u9ad8\u5242\u91cf\u5e76\u91cd\u590d\u7ed9\u836f\u5c55\u73b0\u60ca\u8273\u7684\u4e34\u5e8a\u5b89\u5168\u6027\uff1a<\/i><\/b><\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; ADG126\u5355\u4e00\u7597\u6cd5\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u5df2\u5b8c\u6210\uff0c\u5171\u8ba1\u7ed9\u836f19\u540d\u60a3\u8005\uff0c\u6700\u9ad8\u5242\u91cf\u8fbe\u523020 mg\/kg \uff0c\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u5e76\u91cd\u590d\u7ed9\u836f\uff0c10 mg\/kg\u7684\u5242\u91cf\u6269\u5c55\u8bd5\u9a8c\u7ee7\u7eed\u62db\u52df\u60a3\u8005\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u6839\u636e<a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2022.40.16_suppl.e17601\" target=\"_blank\" rel=\"nofollow noopener\">2022\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\u4e0a\u7684\u6458\u8981\u62a5\u544a<\/a>\uff0c\u53c2\u4e0e\u8bd5\u9a8c\u7684\u60a3\u8005\u5bf9ADG126\u5355\u836f\u5c55\u73b0\u51fa\u4f18\u5f02\u7684\u8010\u53d7\u6027\uff0c\u6240\u6709\u5242\u91cf\u7ec4\u7684\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u4e2d\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u4e0e\u6cbb\u7597\u76f8\u5173\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u5bf9\u6297PD-1\u836f\u7269\u8054\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u8bc4\u4f30\u6b63\u5728\u8fdb\u884c\uff0c\u65e8\u5728\u786e\u5b9a\u4e8c\u671f\u8bd5\u9a8c\u8054\u5408\u7597\u6cd5\u7684\u7ed9\u836f\u5242\u91cf\u548c\u7ed9\u836f\u65f6\u95f4\u3002\u5b89\u5168\u5ba1\u67e5\u59d4\u5458\u4f1a\u6700\u8fd1\u6279\u51c6\u4e86ADG126\u5728\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u7528\u836f\u3002\u65f66 mg\/kg\u6bcf\u4e09\u5468\u7ed9\u836f\u4e00\u6b21\u7684\u5242\u91cf\uff0c\u540c\u65f6\u4e5f\u6279\u51c6\u4e86\u5f00\u5c556 mg\/kg\u7684\u5242\u91cf\u6269\u5c55\uff0c\u5e76\u5efa\u8bae\u5c06\u5242\u91cf\u8fdb\u4e00\u6b65\u9012\u589e\u81f310 mg\/kg\uff0c \u8fd9\u4e5f\u662f\u8fc4\u4eca\u4e3a\u6b62\u6297CTLA-4\u548c\u6297PD-1\u8054\u5408\u6cbb\u7597\u7684\u6700\u9ad8\u5242\u91cf\u6c34\u5e73\u3002<\/p>\n<ul type=\"disc\">\n<li><b><i>\u5728\u51b7\u80bf\u7624\u7684\u6cbb\u7597\u4e2d\u89c2\u5bdf\u5230\u4ee4\u4eba\u632f\u594b\u7684\u5355\u836f\u6297\u80bf\u7624\u6d3b\u6027\uff1a<\/i><\/b><\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; \u5728\u4e00\u7ec4\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c ADG126\u5355\u4e00\u6cbb\u7597\u4f7f\u4e24\u4f4d\u51b7\u80bf\u7624\u60a3\u8005\u7684\u80bf\u7624\u9776\u75c5\u7076\u6301\u7eed\u7f29\u5c0f\u4e14\u8d85\u8fc720%\uff1a<\/p>\n<p class=\"prnml110\">&#8211; \u4e00\u4f4d\u4e3a\u5375\u5de2\u764c\u60a3\u8005\uff0c\u622a\u81f3\u64b0\u7a3f\u65e5\uff0c\u8fd9\u4f4d\u60a3\u8005\u5df2\u63a5\u53d718\u5468\u671f1 mg\/kg\u7684\u6cbb\u7597\uff0c\u8868\u73b0\u51fa\u663e\u8457\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u5176\u5375\u5de2\u764c\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269CA-125\u503c\u5df2\u6301\u7eed\u4e0b\u964d90%\uff0c\u56de\u5f52\u6b63\u5e38\u8303\u56f4\u3002<\/p>\n<p class=\"prnml110\">&#8211; \u4e00\u4f4d\u63a5\u53d7\u8fc7\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u8461\u8404\u819c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u6b64\u524d\u7ecf\u7eb3\u6b66\u5355\u6297(nivolumab)\u4e0e\u4f0a\u5339\u5355\u6297(ipilimumab)\u8054\u5408\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u3002<\/p>\n<p class=\"prnml110\">&#8211; \u6700\u65b0\u4e2d\u671f\u6570\u636e\u5c06\u4f1a\u57289\u670812\u65e5\u4e8e\u5df4\u9ece\u4e3e\u529e\u7684\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u4e0a\u4ee5\u6d77\u62a5\u5f62\u5f0f\u516c\u5e03\uff08\u5927\u4f1a\u4e3e\u529e\u65f6\u95f4\u4e3a2022\u5e749\u67089\u65e5\u81f313\u65e5\uff09\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u5355\u4e00\u6cbb\u7597\u4e0e\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c\u7ee7\u7eed\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u4e0e\u4e9a\u592a\u5730\u533a\u62db\u52df\u665a\u671f\u8f6c\u79fb\u6027\u80bf\u7624\u60a3\u8005\uff0c\u8bc4\u4f30ADG126\u6cbb\u7597\u76ee\u6807\u80bf\u7624\u7684\u4f18\u5316\u5242\u91cf\u3002<\/p>\n<ul type=\"disc\">\n<li><b><i>\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u663e\u793a\u7cbe\u51c6\u63a9\u853d\u6280\u672f\u7684\u6709\u6548\u6027\uff1a<\/i><\/b><\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; \u5728\u5355\u4e00\u7597\u6cd5\u8bc4\u4f30\u4e2d\uff0c\u968f\u7740ADG126\u91cd\u590d\u7ed9\u836f\u7684\u5242\u91cf\u9010\u6e10\u4e0a\u5347\uff0cADG126\u7684\u8840\u6d46\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u8fd1\u4f3c\u7ebf\u6027\u3002ADG126\u7684\u6d3b\u5316\u91cf\u7a33\u6b65\u4e0a\u5347\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u8fd9\u63d0\u793a\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u957f\u671f\u5b58\u5728\u6d3b\u5316ADG126\u3002\u53cd\u590d\u7ed9\u836f\u671f\u95f4\uff0c\u8840\u6d46\u4e2d\u7684\u6fc0\u6d3b\u7684ADG126\u6d53\u5ea6\u5e73\u5747\u589e\u52a02\u500d\u4ee5\u4e0a\u3002<\/p>\n<p><b>ADG106<\/b><b>\uff08\u6fc0\u52a8\u578b\u6297<\/b><b>CD137<\/b><b>\u65b0\u8868\u4f4d\u6297\u4f53<\/b><b>NEObody<\/b><b>&#x2122;\uff09<\/b><\/p>\n<ul type=\"disc\">\n<li><b><i>\u9274\u4e8e\u516c\u53f8\u5c06\u4f18\u5148\u63a8\u8fdb\u5176<\/i><\/b><b><i>CTLA-4 <\/i><\/b><b><i>\u4e34\u5e8a\u9879\u76ee\uff0c\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u8054\u5408\u8bd5\u9a8c\u5c06\u9010\u6e10\u6536\u5c3e\uff1a<\/i><\/b><\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; \u5728\u4e2d\u56fd\u5f00\u5c55\u7684\u8bc4\u4f30ADG106\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u7597\u6cd5\u7684Ib\/II\u671f\u8bd5\u9a8c\uff08ADG106-1008\uff09\u7684\u7ed3\u679c\u663e\u793a\uff0c\u5165\u7ec4\u768420\u4f4d\u60a3\u8005\u4e2d\u6709\u4e00\u4f4d\u9f3b\u54bd\u764c\uff08NPC\uff09\u60a3\u8005\u51fa\u73b0\u90e8\u5206\u7f13\u89e3\u3002\u76ee\u524d\u6709\u56db\u4f4d\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u9274\u4e8e\u516c\u53f8\u5c06\u4f18\u5148\u63a8\u8fdb\u5176\u4e24\u6b3e\u6297CTLA-4 \u4e34\u5e8a\u9879\u76ee\u53ca\u5176\u5177\u6709\u6f5c\u529b\u7684\u4e0b\u4e00\u4ee3\u6297 CD137 \u7597\u6cd5 ADG206\uff0cADG106-1008 \u8bd5\u9a8c\u5c06\u9010\u6e10\u6536\u5c3e\u3002\u6b64\u5916\uff0c\u516c\u53f8\u4e0d\u518d\u5f00\u5c55\u4e4b\u524d\u8ba1\u5212\u7684ADG106\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7597\u6cd5\u8bd5\u9a8c\u3002<\/p>\n<ul type=\"disc\">\n<li><b><i>\u4ee5\u9488\u5bf9\u7279\u5b9a\u9002\u5e94\u75c7\u3001\u7531\u7814\u7a76\u8005\u53d1\u8d77\u7684\u8bd5\u9a8c\uff08<\/i><\/b><b><i>IIT<\/i><\/b><b><i>\uff09\u4e3a\u4e34\u5e8a\u5f00\u53d1\u7126\u70b9\uff1a<\/i><\/b><\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; \u57fa\u4e8e\u516c\u53f8\u5728\u65b0\u52a0\u5761\u7684\u6218\u7565\u5e03\u5c40\u4e0e\u5408\u4f5c\u8ba1\u5212\uff0c\u5929\u6f14\u5c06\u7ee7\u7eed\u652f\u6301\u76ee\u524d\u5728\u65b0\u52a0\u5761\u542f\u52a8\u7684\u7531\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u8fdb\u4e00\u6b65\u63a2\u7d22\u6297CD137\u6297\u4f53\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u7684\u7597\u6548\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u5305\u62ec\uff1a<\/p>\n<p class=\"prnml110\">&#8211; \u8fdb\u884c\u4e2d\u7684Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG106-T6001\uff09\uff0c\u8bc4\u4f30ADG106\u4e0e\u6297PD-1\u6297\u4f53\u7eb3\u6b66\u5355\u6297\u8054\u5408\u7597\u6cd5\u5bf9\u7ecf\u5148\u524d\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002\u76ee\u524d\u5df2\u5b8c\u6210\u5242\u91cf\u9012\u589e\uff0c\u8fdb\u5165\u5242\u91cf\u6269\u5c55\u9636\u6bb5\u3002<\/p>\n<p class=\"prnml110\">&#8211; \u8fdb\u884c\u4e2d\u7684Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG106-T6002\uff09\uff0c\u8bc4\u4f30ADG106\u4e0e\u65b0\u8f85\u52a9\u5316\u7597\uff08\u5148\u7528\u963f\u9709\u7d20\u548c\u73af\u78f7\u9170\u80fa\uff0c\u518d\u7528\u7d2b\u6749\u9187\uff09\u8054\u5408\u7597\u6cd5\u5bf9\u65e9\u671fHER2\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p><b>ADG206<\/b><b>\uff08\u7ecf\u8fc7<\/b><b>Fc<\/b><b>\u7aef\u4f18\u5316\u7684\u6297<\/b><b>CD137 IgG1<\/b><b>\u4e9a\u578b\u63a9\u853d\u5f3a\u529b\u6297\u4f53<\/b><b>POWERbody&#x2122;<\/b><b>\uff09<\/b><\/p>\n<ul type=\"disc\">\n<li><b><i>\u8ba1\u5212\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u7684\u4e0b\u4e00\u4ee3\u6297<\/i><\/b><b><i>CD137\u5019\u9009\u836f\u7269\uff0c\u7ed3\u5408\u63a9\u853d\u3001Fc\u7aef\u4f18\u5316\u4e0e\u521b\u65b0\u8868\u4f4d\u6280\u672f\uff0c\u5b9e\u73b0\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u4e4b\u95f4\u7684\u5e73\u8861\u3002<\/i><\/b><\/li>\n<\/ul>\n<p class=\"prnml80\">&#8211; \u5929\u6f14\u5df2\u5411\u6fb3\u5927\u5229\u4e9a\u7684\u4eba\u4f53\u7814\u7a76\u4f26\u7406\u59d4\u5458\u4f1a\uff08HREC\uff09\u63d0\u4ea4\u7533\u62a5\u6750\u6599\uff0c\u5c06\u7ecf\u8fc7F<sub>C<\/sub>\u7aef\u4f18\u5316\u7684\u6297CD137\u63a9\u853d\u578b\u5f3a\u529b\u6297\u4f53POWERbody&#x2122; ADG206\u63a8\u8fdb\u81f3I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc4\u4f30\u5bf9\u665a\u671f\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u8ba1\u5212\u4e8e2023\u5e74\u521d\u5f00\u5c55\u60a3\u8005\u7ed9\u836f\u8bd5\u9a8c\u3002<\/p>\n<p class=\"prnml80\">&#8211; ADG206\u65e8\u5728\u89e3\u51b3\u6297CD137\u7597\u6cd5\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u95ee\u9898\uff0c\u91c7\u7528\u4e0eADG106\u76f8\u540c\u7684\u521b\u65b0\u8868\u4f4d\uff0c\u5e76\u53c2\u8003\u4e4c\u745e\u82a6\u5355\u6297\uff08urelumab,\u53e6\u4e00\u5bb6\u516c\u53f8\u5f00\u53d1\u7684\u6297CD137\u9776\u5411\u6297\u4f53\uff09\u7684\u7814\u53d1\u7ecf\u9a8c\u53ca\u5176\u51fa\u73b0\u7684\u5355\u4e00\u7597\u6cd5\u7684\u4e34\u5e8a\u6709\u6548\u6027\u4e0e\u5242\u91cf\u4f9d\u8d56\u6027\u809d\u6bd2\u6027\u3002<\/p>\n<p class=\"prnml80\">&#8211; \u4e34\u5e8a\u524d\u6570\u636e\u8868\u660eADG206\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5728\u591a\u79cd\u80bf\u7624\u6a21\u578b\u4e2d\u4f5c\u4e3a\u5355\u4e00\u836f\u5242\u5177\u6709\u7a33\u5b9a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u76f8\u8f83\u4e8e\u4e4c\u745e\u82a6\u5355\u6297\u5bf9\u7167\u7269\uff0c\u5df2\u6fc0\u6d3b\u7684ADG206\u7684\u6297CD137\u6fc0\u52a8\u6d3b\u6027\u5927\u7ea6\u5f3a4\u500d\u3002\u6b64\u5916\uff0cADG206\u8fd8\u5728\u4e0e\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3001\u6297CTLA-4\u836f\u7269\u7b49\u5176\u4ed6\u5236\u5242\u7684\u8054\u5408\u7597\u6cd5\u4e2d\u5c55\u73b0\u51fa\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027<span>\u3002<\/span><\/p>\n<p><b>\u4e34\u5e8a\u524d\u7814\u53d1\u9879\u76ee<\/b><\/p>\n<ul type=\"disc\">\n<li><b><i>ADG<\/i><\/b><b><i>153<\/i><\/b><b><i>\uff1a<\/i><\/b>\u6839\u636e\u66f4\u65b0\u7684\u9879\u76ee\u65f6\u95f4\u8868\u4e0e\u8fdb\u884c\u4e2d\u7684\u5546\u4e1a\u5f00\u53d1\u6d3b\u52a8\uff0c\u5929\u6f14\u76ee\u524d\u8ba1\u5212\u4e8e2023\u5e74\u4e0a\u534a\u5e74\u5bf9\u5f00\u53d1\u4e2d\u7684\u6297CD47\u7684IgG1\u4e9a\u578b\u63a9\u853d\u6297\u4f53ADG153\u63d0\u4ea4IND\u6216\u5176\u4ed6\u540c\u7c7b\u7533\u8bf7\u3002\u8be5\u6297CD47\u7684IgG1\u4e9a\u578b\u5b89\u5168\u6297\u4f53\uff08SAFEbody\uff09\u7684\u51fa\u4f17\u4e4b\u5904\u5728\u4e8e\u5f3a\u5927\u7684\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\u4e0e\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u541e\u566c\uff08ADCP\uff09\u4f5c\u7528\uff0c\u53ef\u5145\u5206\u91ca\u653e\u6297CD47\u836f\u7269\u5bf9\u8840\u6db2\u7624\u548c\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u6548\u679c\u3002<a href=\"https:\/\/adagene-www.s3.us-west-2.amazonaws.com\/pdf\/2022+AACR_ADG153-G1+Poster_FINAL.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u4e34\u5e8a\u524d\u6570\u636e<\/a>\u8868\u660eADG153 IgG1\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e0d\u8bf1\u53d1\u4eba\u4f53\u8840\u51dd\u53cd\u5e94\uff0c\u5e76\u53ef\u5927\u5e45\u964d\u4f4e\u8d2b\u8840\u76f8\u5173\u4e0e\u6297\u539f\u6c89\u9ed8\u7684\u7f3a\u9677\u3002\u7814\u7a76\u7ed3\u679c\u8fd8\u8868\u660eADG153 IgG1\u7684\u6297\u80bf\u7624\u6d3b\u6027\u5f3a\u4e8e\u4e34\u5e8a\u53c2\u7167\u6297\u4f53\uff08\u83ab\u6d1b\u5229\u5355\u6297\u5bf9\u7167\u7269\uff09\u3002<\/li>\n<li><b><i>2022<\/i><\/b><b><i>\u5e74\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff08<\/i><\/b><b><i>AACR<\/i><\/b><b><i>\uff09\u5e74\u4f1a<\/i><\/b>\uff1a\u516c\u53f8\u516c\u5e03\u4e86\u4e09\u6b3e\u9ad8\u5ea6\u5dee\u5f02\u5316\u3001\u540c\u7c7b\u6700\u4f73\u6f5c\u529b\u7684\u4e34\u5e8a\u524d\u5019\u9009\u6297\u4f53\uff08<a href=\"https:\/\/adagene-www.s3.us-west-2.amazonaws.com\/pdf\/ADG206+Poster+AACR2022_Final.pdf\" target=\"_blank\" rel=\"nofollow noopener\">ADG206<\/a>\u3001<a href=\"https:\/\/adagene-www.s3.us-west-2.amazonaws.com\/pdf\/2022+AACR_ADG153-G1+Poster_FINAL.pdf\" target=\"_blank\" rel=\"nofollow noopener\">ADG153<\/a>\u3001<a href=\"https:\/\/adagene-www.s3.us-west-2.amazonaws.com\/pdf\/ADG138+Poster+AACR2022_Final.pdf\" target=\"_blank\" rel=\"nofollow noopener\">ADG138<\/a>\uff09\u6570\u636e\u3002\u8fd9\u4e09\u6b3e\u6297\u4f53\u5747\u91c7\u7528\u5b89\u5168\u6297\u4f53\uff08SAFEbody<sup>&reg;<\/sup>\uff09\u7cbe\u51c6\u63a9\u853d\u6280\u672f\uff0c\u6b63\u5904\u4e8e\u65b0\u836f\u7533\u8bf7\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u3002\u53ef\u767b\u9646\u516c\u53f8\u5b98\u65b9\u7f51\u7ad9\u7684<a href=\"https:\/\/www.adagene.com\/zh\/pipeline-2\/publications-2\/\" target=\"_blank\" rel=\"nofollow noopener\">\u53d1\u8868\u6587\u732e<\/a>\u9875\u9762\u67e5\u9605\u76f8\u5173\u6d77\u62a5\u3002<\/li>\n<li><b><i>CD28<\/i><\/b> <b><i>T<\/i><\/b><b><i>\u7ec6\u80de\u63a5\u5408\u5668\uff08<\/i><\/b><b><i>TCE<\/i><\/b><b><i>\uff09<\/i><\/b>\uff1a\u540c\u6837\u5728AACR\u5e74\u4f1a\u4e0a\uff0c\u5929\u6f14\u8fd8\u516c\u5e03\u4e86\u5173\u4e8e\u65b0\u578b\u72ec\u6709\u7684CD28\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u63a5\u5408\u5668\uff08TCE\uff09\u7684\u6570\u636e\u3002CD28\u53cc\u7279\u5f02\u6027\u5f3a\u529b\u6297\u4f53POWERbody<sup>TM<\/sup> TCE\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u53ef\u4e0eCD3\u53cc\u7279\u5f02\u6027TCE\u548c\/\u6216\u68c0\u67e5\u70b9\u6291\u5236\u5242\u76f8\u7ed3\u5408\uff0c\u521b\u9020\u5b89\u5168\u6301\u4e45\u7684T\u7ec6\u80de\u4ecb\u5bfc\u534f\u540c\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u3002<a href=\"https:\/\/adagene-www.s3.us-west-2.amazonaws.com\/pdf\/CD28+BsAb+Poster+AACR2022_Final.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u4e34\u5e8a\u524d\u6570\u636e<\/a>\u8868\u660e\uff0cCD28\u6fc0\u6d3b\u65f6\u4ea7\u751f\u7684\u4e25\u91cd\u5b89\u5168\u95ee\u9898\u6709\u671b\u5f97\u5230\u7f13\u89e3\uff0c\u5e76\u4e14\u901a\u8fc7\u6253\u9020\u9776\u5411\u9ad8\u5ea6\u4fdd\u5b88\u7684\u72ec\u7279\u8868\u4f4d\uff0c\u53ef\u5f00\u53d1\u51fa\u5177\u5907\u8de8\u7269\u79cd\u4ea4\u53c9\u53cd\u5e94\u7684\u5b9a\u5236\u6297\u4f53\u3002\u516c\u53f8\u6b63\u5728\u5f00\u53d1\u591a\u6b3e\u80bf\u7624\u76f8\u5173\u6297\u539f\uff08TAA\uff09x CD28 POWERbody<sup>TM<\/sup>\u5f3a\u529b\u6297\u4f53\uff0c\u5982B7-H3xCD28\u548cTROP2xCD28\uff0c\u4e5f\u53ef\u4e0e\u5929\u6f14\u7684CD3 TCE\u6216\u5176\u5b83\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u76f8\u8054\u5408\u4ee5\u5b9e\u73b0\u5b89\u5168\u3001\u5f3a\u6548\u800c\u6301\u4e45\u7684\u5b9e\u4f53\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u3002\u53ef\u767b\u9646\u516c\u53f8\u5b98\u65b9\u7f51\u7ad9\u7684<a href=\"https:\/\/www.adagene.com\/zh\/pipeline-2\/publications-2\/\" target=\"_blank\" rel=\"nofollow noopener\">\u53d1\u8868\u6587\u732e<\/a>\u9875\u9762\u67e5\u9605\u76f8\u5173\u6d77\u62a5\u3002<\/li>\n<\/ul>\n<p><b>\u5546\u4e1a\u5408\u4f5c<\/b><\/p>\n<ul type=\"disc\">\n<li><b><i>\u8d5b\u8bfa\u83f2<\/i><\/b>: 2022\u5e743\u6708\uff0c\u516c\u53f8\u4e0e\u8d5b\u8bfa\u83f2\u8fbe\u6210\u4e00\u9879\u6280\u672f\u6388\u6743\u534f\u8bae\uff0c\u8d5b\u8bfa\u83f2\u63d0\u4f9b\u5355\u514b\u9686\u4e0e\u53cc\u7279\u5f02\u6027\u5019\u9009\u6297\u4f53\uff0c\u5929\u6f14\u63d0\u4f9b\u8fd9\u4fe9\u6b3e\u6297\u4f53\u7684\u7cbe\u51c6\u63a9\u853d\u540e\u7684\u5b89\u5168\u6297\u4f53\uff08SAFEbody<sup>&reg;<\/sup>\uff09\uff0c\u4ea4\u6613\u6f5c\u503c\u9ad8\u8fbe25\u4ebf\u7f8e\u5143\u3002\u672c\u6b21\u5408\u4f5c\u5305\u62ec\u4e00\u7b141750\u4e07\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\uff0c\u5df2\u4e8e2022\u5e744\u6708\u5230\u8d26\uff0c\u7528\u4e8e\u9996\u5148\u542f\u52a8\u4e24\u4e2a\u9879\u76ee\uff08\u6bcf\u4e2a\u9879\u76ee875\u4e07\u7f8e\u5143\uff09\uff0c\u548c\u4e00\u7b14\u63d0\u540d\u989d\u5916\u4e24\u4e2a\u9879\u76ee\u7684\u9644\u52a0\u8d39\u7528\uff0c\u8fd8\u5305\u62ec\u6700\u9ad8\u53ef\u8fbe25\u4ebf\u7f8e\u5143\uff08\u6bcf\u4e2a\u9879\u76ee6.25\u4ebf\u7f8e\u5143\uff09\u7684\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u5206\u7ea7\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/li>\n<li><b><i>Exelixis<\/i><\/b>\uff1a2022\u5e741\u6708\uff0c\u4e8e\u5408\u4f5c\u9879\u76ee\u4e2d\u6210\u529f\u7b5b\u9009\u5230\u9996\u4e2a\u76ee\u6807\u5b89\u5168\u6297\u4f53\u5019\u9009\u836f\u7269\uff0c\u5e76\u83b7\u5f97\u4e00\u7b14300\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u968f\u540e\u4e8e2022\u5e746\u6708\u83b7\u5f97\u4e00\u7b14110\u4e07\u7f8e\u5143\u7684\u989d\u5916\u9884\u4ed8\u6b3e\u3002\u8fd9\u4e24\u7b14\u4ed8\u6b3e\u6e90\u4e8e2021\u5e742\u6708\u4e0eExelixis\u4e3a\u5f00\u53d1\u521b\u65b0\u63a9\u853d\u578b\u5b89\u5168\u6297\u4f53\u5076\u8054\u836f\u7269\u800c\u8fbe\u6210\u7684\u6280\u672f\u6388\u6743\u534f\u8bae\u3002\u8be5\u534f\u8bae\u4e2d\u5305\u62ec\u4e00\u7b14\u7528\u4e8e\u4e24\u4e2a\u9879\u76ee\u76841100\u4e07\u7f8e\u5143\u9996\u4ed8\u6b3e\u3001\u6f5c\u5728\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4ee5\u53ca\u5206\u7ea7\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/li>\n<li><b><i>\u4e2d\u56fd<\/i><\/b>\uff1a\u63a8\u8fdb\u5168\u7403\u4f19\u4f34\u5408\u4f5c\u4ee5\u53ca\u4e0e\u6842\u6797\u4e09\u91d1\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u53ca\u5176\u9644\u5c5e\u516c\u53f8\u5728\u5927\u4e2d\u534e\u533a\u7684\u4e24\u9879\u6297\u4f53\u6280\u672f\u6388\u6743\u5408\u4f5c\uff0c\u5305\u62ec\u4e00\u6b3e\u5904\u4e8eII\u671f\u5f00\u53d1\u7684\u6297PD-L1\u6297\u4f53\uff08ADG104\uff09\u548c\u4e00\u6b3e\u5904\u4e8eI\u671f\u5f00\u53d1\u7684\u521b\u65b0\u6297CSF-1R\u6297\u4f53\uff08ADG125\/BC006\uff09\u3002<\/li>\n<\/ul>\n<p><b>\u516c\u53f8\u6700\u65b0\u52a8\u6001<\/b><\/p>\n<ul type=\"disc\">\n<li>\u9274\u4e8e\u7f8e\u56fd\u653f\u5e9c\u7684\u300a\u5916\u56fd\u516c\u53f8\u95ee\u8d23\u6cd5\u6848\u300b(HFCAA)\uff0c\u4ee5\u53ca\u5982\u679c\u5728\u63d0\u4ea42023\u5e7420-F\u5168\u5e74\u8d22\u62a5\u524d\uff0c\u300a\u52a0\u901f\u5916\u56fd\u516c\u53f8\u95ee\u8d23\u6cd5\u6848\u300b\uff08AHFCA\uff09\u901a\u8fc7\u800c\u51fa\u53f0\u7684\u8bdd\uff0c\u9274\u4e8e\u8be5\u7b49\u300a\u52a0\u901f\u5916\u56fd\u516c\u53f8\u95ee\u8d23\u6cd5\u6848\u300b\uff0c\u5929\u6f14\u836f\u4e1a\u6b63\u79ef\u6781\u8bc4\u4f30\u5176\u4e1a\u52a1\u6d41\u7a0b\uff0c\u4ee5\u6ee1\u8db3\u4ee5\u4e0a\u4e24\u9879\u6cd5\u6848\u7684\u8981\u6c42\u3002\u516c\u53f8\u6b63\u5bc6\u5207\u5173\u6ce8HFCAA\u548cAHFCA\u6240\u5e26\u6765\u7684\u540e\u7eed\u5f71\u54cd\u5e76\u91c7\u53d6\u5fc5\u8981\u63aa\u65bd\u4ee5\u964d\u4f4e\u5bf9\u516c\u53f8\u7684\u5f71\u54cd\u3002<\/li>\n<li><b><i>\u5929\u6f14\u7ee7\u7eed\u4f18\u5316\u8fd0\u8425<\/i><\/b>\uff0c\u4e13\u6ce8\u4e8e\u6700\u5148\u8fdb\u3001\u6700\u5177\u6f5c\u529b\u7684\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u9879\u76ee\uff0c\u540c\u65f6\u51cf\u5c11\u73b0\u91d1\u6d88\u8017\u3002<\/li>\n<\/ul>\n<p><b><u>\u9884\u671f\u91cc\u7a0b\u7891\u4e0e\u5c55\u671b<\/u><\/b><\/p>\n<p>\u7ecf\u8fc7\u8c03\u6574\u7684\u4e1a\u52a1\u5c55\u671b\u53cd\u6620\u51fa\u5929\u6f14\u5bf9\u5176\u6297CTLA-4\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u7684\u91cd\u89c6\uff0c\u4ee5\u53ca\u5229\u7528\u73b0\u6709\u73b0\u91d1\u8d44\u6e90\u5b9e\u73b0\u91cd\u5927\u91cc\u7a0b\u7891\u7684\u76ee\u6807\u3002\u57fa\u4e8e\u76ee\u524d\u89c4\u5212\uff0c\u5929\u6f14\u9884\u8ba1\u516c\u53f8\u8d44\u91d1\u53ef\u652f\u6301\u516c\u53f8\u52302024\u5e74\u4e0b\u534a\u5e74\u7684\u8fd0\u8425\u6d3b\u52a8\uff0c\u5e76\u5b9e\u73b0\u4ee5\u4e0b\u91cc\u7a0b\u7891\uff1a<\/p>\n<p><u>2022<\/u><u>\u5e74<\/u><\/p>\n<ul type=\"disc\">\n<li>\u57282022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5927\u4f1a\u4e0a\u516c\u5e03ADG126\u5355\u4e00\u7597\u6cd5\u5242\u91cf\u9012\u589e\u6570\u636e<\/li>\n<li>\u57282022\u5e74\u7f8e\u56fd\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a\u5e74\u4f1a\u4e0a\u516c\u5e03\u5173\u4e8eADG116\u7684\u66f4\u591a\u6570\u636e<\/li>\n<li>\u6839\u636eADG116\u4e0e\u6297PD-1\u836f\u7269\u8054\u5408\u7597\u6cd5\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u7ed3\u679c\u786e\u5b9a\u5242\u91cf\u6269\u5c55\u9636\u6bb5\u7684\u7ed9\u836f\u91cf\u548c\u65f6\u95f4\u5b89\u6392\uff1b\u63a8\u8fdbIIa\u671f\u9488\u5bf9\u76ee\u6807\u80bf\u7624\u7684\u5242\u91cf\u6269\u5c55\u961f\u5217<\/li>\n<li>\u6839\u636eADG126\u4e0e\u6297PD-1\u836f\u7269\u8054\u5408\u7597\u6cd5\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u7ed3\u679c\u786e\u5b9a\u5242\u91cf\u6269\u5c55\u9636\u6bb5\u7684\u7ed9\u836f\u91cf\u548c\u65f6\u95f4\u5b89\u6392\uff1b\u63a8\u8fdbIIa\u671f\u9488\u5bf9\u76ee\u6807\u80bf\u7624\u7684\u5242\u91cf\u6269\u5c55\u961f\u5217<\/li>\n<\/ul>\n<p><u>2023<\/u><u>\u5e74<\/u><\/p>\n<ul type=\"disc\">\n<li>\u6765\u81eaADG116\u8054\u5408\u5242\u91cf\u6269\u5c55\u961f\u5217\u7684IIa\u671f\u6982\u5ff5\u9a8c\u8bc1\u6570\u636e<\/li>\n<li>\u6765\u81eaADG126\u8054\u5408\u5242\u91cf\u6269\u5c55\u961f\u5217\u7684IIa\u671f\u6982\u5ff5\u9a8c\u8bc1\u6570\u636e<\/li>\n<li>\u660e\u786e\u6297CTLA-4\u4e0e\u6297PD-1\u836f\u7269\u8054\u5408\u6cbb\u7597\u76ee\u6807\u80bf\u7624\u7684II\/III\u671f\u67a2\u7ebd\u8bd5\u9a8c\u5f00\u53d1\u8def\u5f84\u4e0e\u7b56\u7565\uff08\u5982II\u671f\u7684\u63a8\u8350\u5242\u91cf\u3001\u9002\u5e94\u75c7\u548c\u8bbe\u8ba1\uff09<\/li>\n<li>\u5728ADG206 I\u671f\u8bd5\u9a8c\u4e2d\u542f\u52a8\u60a3\u8005\u7ed9\u836f<\/li>\n<li>\u4e3aADG153\u63d0\u4ea4IND\u6216\u5176\u4ed6\u540c\u7c7b\u7533\u8bf7\uff0c\u5e76\u542f\u52a8I\u671f\u8bd5\u9a8c<\/li>\n<li>ADG106\u7684IIT\u8054\u5408\u7814\u7a76\u7ed3\u679c<\/li>\n<li>\u5f00\u5c55\u66f4\u591a\u5408\u4f5c\u9879\u76ee\u6216\/\u4e0e\u6280\u672f\u6388\u6743\u5408\u4f5c<\/li>\n<\/ul>\n<p><b><u>\u8d22\u52a1<\/u><\/b><b><u>\u4eae\u70b9<\/u><\/b><\/p>\n<p><u>\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269<\/u><br \/>\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269\u4ece2021\u5e7412\u670831\u65e5\u7ea617,440\u4e07\u7f8e\u5143\u4e0a\u5347\u52302022\u5e746\u670830\u65e5\u7ea616,800\u4e07\u7f8e\u5143\u30022022\u5e74\u7684\u73b0\u91d1\u4f59\u989d\u5305\u542b\u4e86\u8d5b\u8bfa\u83f2\u4e3a\u8fbe\u6210\u7684\u6280\u672f\u8bb8\u53ef\u5408\u4f5c\u800c\u652f\u4ed8\u76841,750\u4e07\u7f8e\u5143\u9996\u4ed8\u6b3e\uff0c\u4eceExelixis\u83b7\u5f97\u7684300\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4ee5\u53ca110\u4e07\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\u3002<\/p>\n<p><u>\u51c0\u6536\u5165<\/u><br \/>\u51c0\u6536\u5165\u76f8\u8f83\u4e8e2021\u5e74\u540c\u671f\u7684140\u4e07\u7f8e\u5143\u589e\u52a0\u52302022\u5e746\u670830\u65e5\u7684390\u4e07\u7f8e\u5143\u3002\u51c0\u6536\u5165\u7684\u589e\u957f\u6765\u6e90\u4e3a\u516c\u53f8\u786e\u8ba4\u4e86\u4e0e\u8d5b\u8bfa\u83f2\u8fbe\u6210\u7684\u6280\u672f\u8bb8\u53ef\u5408\u4f5c\u534f\u8bae\u4e2d\u7684\u90e8\u5206\u6536\u5165\u3002\u8be5\u7b14\u6536\u5165\u7684\u786e\u8ba4\u662f\u57fa\u4e8e\u516c\u53f8\u5728\u9010\u6b65\u5c65\u884c\u4e0e\u8d5b\u8bfa\u83f2\u5408\u4f5c\u5f00\u53d1\u6297\u4f53\u7597\u6cd5\u76f8\u5173\u7684\u5c65\u7ea6\u4e49\u52a1\u3002\u7531\u4e8e\u516c\u53f8\u4e0e\u8d5b\u8bfa\u83f2\u4ee5\u53caExelixis\u7684\u6280\u672f\u8bb8\u53ef\u5408\u4f5c\uff0c\u5408\u540c\u8d1f\u503a\u75312021\u5e7412\u670831\u65e5\u7684550\u4e07\u7f8e\u5143\u589e\u52a0\u81f32022\u5e746\u670830\u65e5\u76842,020\u4e07\u7f8e\u5143\u3002<\/p>\n<p><u>\u7814\u53d1\u8d39\u7528<\/u><br \/>\u7814\u53d1\u8d39\u7528\u76f8\u8f83\u4e8e2021\u5e74\u540c\u671f\u76843,150\u4e07\u7f8e\u5143\u589e\u52a0\u52302022\u5e746\u670830\u65e5\u76844,510\u4e07\u7f8e\u5143\u3002\u7814\u53d1\u8d39\u7528\u7684\u589e\u52a0\u4e3b\u8981\u662f\u7531\u4e8e\u4e0e\u516c\u53f8\u4e34\u5e8a\u9879\u76ee\u4ee5\u53ca\u65b0\u836f\u7533\u8bf7\u7684\u4e34\u5e8a\u524d\u6d4b\u8bd5\u76f8\u5173\u7684\u7814\u53d1\u6d3b\u52a8\u7684\u6301\u7eed\u589e\u957f\u3002<\/p>\n<p><u>\u7ba1\u7406\u8d39\u7528<\/u><br \/>\u7ba1\u7406\u8d39\u7528\u76f8\u8f83\u4e8e2021\u5e74\u540c\u671f\u7684740\u4e07\u7f8e\u5143\u51cf\u5c11\u52302022\u5e746\u670830\u65e5\u7684680\u4e07\u7f8e\u5143\u3002\u7ba1\u7406\u8d39\u7528\u7684\u51cf\u5c11\u4e3b\u8981\u662f\u7531\u4e8e\u975e\u73b0\u91d1\u80a1\u4efd\u85aa\u916c\u7684\u51cf\u5c11\u3002<\/p>\n<p><u>\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08<\/u><u>GAAP<\/u><u>\uff09\u4e0b\u7684<\/u><u>\u51c0\u4e8f\u635f<\/u><br \/>\u51c0\u4e8f\u635f\u76f8\u8f83\u4e8e2021\u5e74\u540c\u671f\u76843,720\u4e07\u7f8e\u5143\u589e\u52a0\u52302022\u5e746\u670830\u65e5\u76844,760\u4e07\u7f8e\u5143\u3002<\/p>\n<p><u>\u6d41\u901a\u5728\u5916\u666e\u901a\u80a1<\/u><br \/>\u622a\u6b62\u81f32022\u5e746\u670830\u65e5\uff0c\u516c\u53f8\u6d41\u901a\u5728\u5916\u7684\u666e\u901a\u80a1\u4e3a54,278,981\u80a1\u3002\u6bcf\u4e00\u80a1\u7f8e\u56fd\u5b58\u6258\u80a1\u7968(ADS)\u53ef\u6362\u7b97\u4e3a1.25\u80a1\u666e\u901a\u80a1\u3002<\/p>\n<p><u>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219<\/u><u>\uff08<\/u><u>Non-GAAP\uff09<\/u><u>\u4e0b\u7684<\/u><u>\u51c0\u4e8f\u635f<\/u><br \/>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5b9a\u4e49\u4e3a\u8be5\u671f\u95f4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5254\u9664\u4ee5\u4e0b\u9879\u76ee\uff1a(i) \u80a1\u6743\u6fc0\u52b1\u8d39\u7528\uff0c\u4ee5\u53ca (ii) \u53ef\u8f6c\u6362\u53ef\u8d4e\u56de\u4f18\u5148\u80a1\u589e\u52a0\u81f3\u53ef\u8d4e\u56de\u4ef7\u503c\u3002\u8be5\u91d1\u989d\u4ece2021\u5e74\u540c\u671f\u76842,700\u4e07\u7f8e\u5143\u589e\u52a0\u52302022\u5e746\u670830\u65e5\u76844,190\u4e07\u7f8e\u5143\u3002\u8bf7\u53c2\u9605\u672c\u65b0\u95fb\u7a3f\u4e2d\u9898\u4e3a&quot;\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868&quot;\u90e8\u5206\u4e86\u89e3\u8be6\u60c5\u3002<\/p>\n<p><b>\u5bf9\u4e8e\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08<\/b><b>Non-GAAP<\/b><b>\uff09\u8d22\u52a1\u6307\u6807\u7684\u8861\u91cf<\/b><\/p>\n<p>\u5929\u6f14\u836f\u4e1a\u4f7f\u7528Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u7528\u4e8e\u8bc4\u4f30\u672c\u516c\u53f8\u7684\u7ecf\u8425\u6210\u679c\uff0c\u4ee5\u53ca\u8d22\u52a1\u548c\u7ecf\u8425\u51b3\u7b56\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u6709\u52a9\u4e8e\u8bc6\u522b\u672c\u516c\u53f8\u4e1a\u52a1\u7684\u57fa\u672c\u8d8b\u52bf\uff0c\u800c\u8fd9\u4e9b\u8d8b\u52bf\u53ef\u80fd\u56e0\u672c\u516c\u53f8\u8ba1\u5165\u672c\u5e74\u5ea6\/\u671f\u95f4\u4e8f\u635f\u7684\u67d0\u4e9b\u8d39\u7528\u7684\u5f71\u54cd\u800c\u626d\u66f2\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u63d0\u4f9b\u4e86\u6709\u5173\u5176\u7ecf\u8425\u6210\u679c\u7684\u6709\u7528\u4fe1\u606f\uff0c\u6574\u4f53\u63d0\u5347\u4e86\u5bf9\u5176\u8fc7\u53bb\u4e1a\u7ee9\u548c\u672a\u6765\u524d\u666f\u7684\u5168\u9762\u4e86\u89e3\uff0c\u5e76\u4f7f\u7ba1\u7406\u5c42\u5728\u8d22\u52a1\u548c\u8fd0\u8425\u51b3\u7b56\u4e2d\u4f7f\u7528\u7684\u5173\u952e\u6307\u6807\u66f4\u5177\u53ef\u89c1\u6027\u3002<\/p>\n<p>\u5bf9\u4e8e\u672c\u5e74\u5ea6\/\u671f\u95f4\u7684Non-GAAP\u8d22\u52a1\u6307\u6807\u7684\u8861\u91cf\uff0c\u5929\u6f14\u836f\u4e1a\u4f7f\u7528\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u4e0d\u5e94\u5355\u72ec\u88ab\u8003\u8651\uff0c\u4e5f\u4e0d\u5e94\u88ab\u89c6\u4e3a\u8be5\u5e74\u5ea6\/\u671f\u95f4\u8425\u4e1a\u5229\u6da6\u3001\u51c0\u4e8f\u635f\u6216\u4efb\u4f55\u5176\u4ed6\u4e1a\u7ee9\u8861\u91cf\u6307\u6807\u7684\u66ff\u4ee3\u54c1\uff0c\u6216\u4f5c\u4e3a\u5176\u7ecf\u8425\u4e1a\u7ee9\u7684\u8861\u91cf\u6307\u6807\u3002\u516c\u53f8\u9f13\u52b1\u6295\u8d44\u8005\u5ba1\u9605\u8be5\u5e74\u5ea6\/\u671f\u95f4\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u5e76\u5ba1\u9605\u6700\u76f4\u63a5\u53ef\u6bd4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u8d22\u52a1\u6307\u6807\u7684\u8c03\u6574\u8fc7\u7a0b\u3002\u6b64\u5904\u6240\u5217\u5e74\u5ea6\/\u671f\u95f4\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u53ef\u80fd\u65e0\u6cd5\u4e0e\u5176\u4ed6\u516c\u53f8\u63d0\u4f9b\u7684\u7c7b\u4f3c\u540d\u79f0\u7684\u8d22\u52a1\u6307\u6807\u76f8\u6bd4\u8f83\u3002\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u4f1a\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u8ba1\u7b97\u7c7b\u4f3c\u7684\u8d22\u52a1\u6307\u6807\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5b83\u4eec\u4f5c\u4e3a\u516c\u53f8\u53ef\u6bd4\u6570\u636e\u7684\u6709\u7528\u6027\u3002\u5929\u6f14\u836f\u4e1a\u9f13\u52b1\u6295\u8d44\u8005\u548c\u5176\u4ed6\u4eba\u5168\u9762\u5ba1\u9605\u672c\u516c\u53f8\u7684\u8d22\u52a1\u4fe1\u606f\uff0c\u800c\u4e0d\u662f\u4ec5\u4ec5\u5173\u6ce8\u4e8e\u5355\u4e00\u7684\u8d22\u52a1\u6307\u6807\u3002<\/p>\n<p>\u672c\u5e74\u5ea6\u8ba1\u7b97\u7684\u51c0\u5229\u6da6\u6307\u6807\u4e0bNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u4e0d\u5305\u62ec\uff1a\uff08i\uff09\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\uff0c\uff08ii\uff09\u53ef\u8f6c\u6362\u53ef\u8d4e\u56de\u4f18\u5148\u80a1\u589e\u52a0\u81f3\u53ef\u8d4e\u56de\u4ef7\u503c\u3002\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u662f\u5411\u5458\u5de5\u6388\u4e88\u80a1\u7968\u6fc0\u52b1\u6240\u4ea7\u751f\u7684\u975e\u73b0\u91d1\u8d39\u7528\u3002\u6211\u4eec\u8ba4\u4e3a\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u7684\u8c03\u6574\u4fe1\u606f\u80fd\u5bf9\u7ba1\u7406\u5c42\u548c\u6295\u8d44\u4eba\u5728\u8fdb\u884c\u516c\u53f8\u8fd0\u8425\u8868\u73b0\u7684\u540c\u671f\u6bd4\u8f83\u4ee5\u53ca\u540c\u4e1a\u6bd4\u8f83\u65f6\u6709\u6240\u52a9\u76ca\u3002\u5176\u539f\u56e0\u6709\uff1a\uff08i\uff09\u5728\u67d0\u7279\u5b9a\u671f\u95f4\u5185\u7684\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u4e0e\u516c\u53f8\u7684\u8fd0\u8425\u8868\u73b0\u672a\u5fc5\u76f4\u63a5\u76f8\u5173\uff1b\uff08ii\uff09\u56e0\u516c\u53f8\u6388\u4e88\u65b0\u7684\u80a1\u6743\u6fc0\u52b1\u8ba1\u5212\u7684\u65f6\u95f4\u5b89\u6392\uff0c\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u5728\u4e0d\u540c\u671f\u95f4\u5185\u53ef\u80fd\u4f1a\u53d1\u751f\u8f83\u5927\u53d8\u5316\uff1b\u4ee5\u53ca\uff0c\uff08iii\uff09\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u91c7\u53d6\u4e0d\u540c\u7684\u80a1\u6743\u6fc0\u52b1\u5f62\u5f0f\u6216\u8005\u4f7f\u7528\u4e0d\u540c\u7684\u4f30\u503c\u65b9\u6cd5\u3002<\/p>\n<p>\u8bf7\u53c2\u9605\u672c\u516c\u544a\u7ed3\u5c3e\u7684&nbsp;&quot;\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868&quot;\uff0c\u83b7\u53d6\u672c\u5e74\u5ea6\/\u671f\u95f4Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u7684\u5b8c\u6574\u7684\u8c03\u6574\u8fc7\u7a0b\u3002<\/p>\n<p><b>\u5173\u4e8e\u5929\u6f14\u836f\u4e1a<\/b><\/p>\n<p>\u5929\u6f14\u836f\u4e1a\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u5e73\u53f0\u9a71\u52a8\u5e76\u62e5\u6709\u81ea\u4e3b\u5e73\u53f0\u4ea7\u51fa\u7684\u4e34\u5e8a\u4ea7\u54c1\u5f00\u53d1\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\u501f\u529b\u4e8e\u8ba1\u7b97\u751f\u7269\u5b66\u4e0e\u4eba\u5de5\u667a\u80fd\uff0c\u51ed\u501f\u5176\u5168\u7403\u9996\u521b\u7684\u4e09\u4f53\u5e73\u53f0\u6280\u672f\uff08\u65b0\u8868\u4f4d\u6297\u4f53NEObody&#x2122;\uff0c\u5b89\u5168\u6297\u4f53SAFEbody&reg;\u53ca\u5f3a\u529b\u6297\u4f53POWERbody&#x2122;\uff09\uff0c\u5929\u6f14\u836f\u4e1a\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u4e8e\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u72ec\u7279\u539f\u521b\u7684\u6297\u4f53\u4ea7\u54c1\u7ebf\uff0c\u4ee5\u89e3\u51b3\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u4e2a\u5168\u7403\u77e5\u540d\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5e76\u4ee5\u5176\u591a\u79cd\u539f\u521b\u524d\u6cbf\u79d1\u6280\u4e3a\u5408\u4f5c\u4f19\u4f34\u7684\u65b0\u836f\u7814\u53d1\u8d4b\u80fd\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1a&nbsp;<u><a href=\"https:\/\/investor.adagene.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/investor.adagene.com&nbsp;<\/a><\/u>\u5e76\u5173\u6ce8\u5929\u6f14\u836f\u4e1a<u><a href=\"https:\/\/t.prnasia.com\/t\/qgUNymgw\" target=\"_blank\" rel=\"nofollow noopener\">\u5fae\u4fe1<\/a><\/u>\u3001<u><a href=\"https:\/\/t.prnasia.com\/t\/QuTV1aBS\" target=\"_blank\" rel=\"nofollow noopener\">\u9886\u82f1<\/a><\/u>\u53ca<u><a href=\"https:\/\/t.prnasia.com\/t\/9qfrA1Nr\" target=\"_blank\" rel=\"nofollow noopener\">\u63a8\u7279<\/a><\/u>\u5b98\u65b9\u5e10\u53f7\u3002<\/p>\n<p>SAFEbody&reg; \u4e3a\u5929\u6f14\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b27\u76df\u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n<p><b>\u5b89\u5168\u6e2f\u58f0\u660e<\/b>&nbsp;<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u5173\u4e8e\u4e34\u5e8a\u6570\u636e\u5bf9\u60a3\u8005\u7684\u6f5c\u5728\u5f71\u54cd\u7684\u9648\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u7684\u63a8\u8fdb\u548c\u9884\u671f\u7684\u4e34\u5e8a\u524d\u6d3b\u52a8\u3001\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u4ee5\u53ca\u5176\u5019\u9009\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5929\u6f14\u836f\u4e1a\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u793a\u7684\u7ed3\u679c\u5b58\u5728\u91cd\u5927\u5dee\u5f02\uff1b\u5176\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u76d1\u7ba1\u6279\u51c6\uff1b\u76f8\u5173\u76d1\u7ba1\u673a\u6784\u5c31\u5929\u6f14\u836f\u4e1a\u5019\u9009\u836f\u7269\u7684\u76d1\u7ba1\u6279\u51c6\u505a\u51fa\u51b3\u5b9a\u7684\u5185\u5bb9\u548c\u65f6\u95f4\uff1b\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u5019\u9009\u836f\u7269\u53d6\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u6280\u672f\u548c\u836f\u7269\u83b7\u5f97\u548c\u7ef4\u6301\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u5236\u9020\u548c\u5176\u4ed6\u670d\u52a1\uff1b\u5929\u6f14\u836f\u4e1a\u6709\u9650\u7684\u7ecf\u8425\u5386\u53f2\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u83b7\u5f97\u989d\u5916\u8fd0\u8425\u8d44\u91d1\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u5728\u5176\u73b0\u6709\u6218\u7565\u4f19\u4f34\u5173\u7cfb\u6216\u5408\u4f5c\u4e4b\u5916\u7b7e\u8ba2\u989d\u5916\u5408\u4f5c\u534f\u8bae\u7684\u80fd\u529b\uff0c\u4ee5\u53caCOVID-19 \u6d41\u884c\u5bf9\u5929\u6f14\u836f\u4e1a\u4e34\u5e8a\u5f00\u53d1\u3001\u5546\u4e1a\u548c\u5176\u4ed6\u8fd0\u8425\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u63d0\u4ea4\u7ed9\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u768420-F\u5f62\u5f0f\u76842021\u5e74\u7684\u5e74\u5ea6\u62a5\u544a\u4e2d&quot;\u98ce\u9669\u56e0\u7d20&quot;\u90e8\u5206\u66f4\u5145\u5206\u8ba8\u8bba\u7684\u90a3\u4e9b\u98ce\u9669\u3002\u6240\u6709\u524d\u77bb\u6027\u9648\u8ff0\u5747\u57fa\u4e8e\u5929\u6f14\u836f\u4e1a\u5f53\u524d\u53ef\u83b7\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u4f9d\u7167\u6cd5\u5f8b\u4e4b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u836f\u4e1a\u4e0d\u627f\u62c5\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u5f00\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u7684\u4e49\u52a1<b>\u3002<\/b><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"4\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d22\u52a1\u62a5\u8868<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"4\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"4\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u672a\u7ecf\u5ba1\u8ba1\u7684\u5408\u5e76\u8d44\u4ea7\u8d1f\u503a\u8868\uff08\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u6b62\u81f3<\/b><b>2021\u5e74<br \/>12\u670831\u65e5<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u6b62\u81f3<\/b><b>2022\u5e746<br \/>\u670830\u65e5<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>US$<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d44\u4ea7<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d44\u4ea7:<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">174,391,243<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">168,035,499<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u6536\u8d26\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,000,000<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u6536\u5173\u8054\u65b9\u6b3e\u9879<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,506,670<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,870,082<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u6d41\u52a8\u8d44\u4ea7\u548c\u9884\u4ed8\u8d26\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,055,921<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,107,271<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d44\u4ea7\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>185,953,834<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>175,012,852<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u56fa\u5b9a\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,487,617<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,072,032<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4f7f\u7528\u6743\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">399,789<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52a8\u8d44\u4ea7<\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">69,275<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">72,799<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d44\u4ea7\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>189,510,726<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>178,557,472<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">&nbsp;<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d1f\u503a\u548c\u80a1\u4e1c\u6743\u76ca<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d1f\u503a:<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u8d26\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,321,615<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,665,872<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5408\u540c\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,500,000<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">20,176,826<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ed8\u5173\u8054\u65b9\u6b3e\u9879<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">10,466,061<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">17,508,933<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u9884\u63d0\u53ca\u5176\u4ed6\u6d41\u52a8\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,379,243<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,237,621<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e94\u4ea4\u6240\u5f97\u7a0e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,657,450<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,256,601<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u77ed\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,121,226<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,960,008<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5185\u5230\u671f\u7684\u957f\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,376,319<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,352,177<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5185\u5230\u671f\u7684\u79df\u8d41\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">297,066<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6d41\u52a8\u8d1f\u503a\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>29,821,914<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>56,455,104<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u957f\u671f\u501f\u6b3e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,991,829<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">9,260,363<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u79df\u8d41\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">128,083<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u9012\u5ef6\u6240\u5f97\u7a0e\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">44,163<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52a8\u8d1f\u503a<\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">94,107<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">29,800<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d1f\u503a\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>32,952,013<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>65,873,350<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">&nbsp;<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u80a1\u4e1c\u6743\u76ca:<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,627<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,657<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5e93\u5b58\u80a1<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(619,605)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(3,666,957)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u8d44\u672c\u516c\u79ef<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">336,099,931<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">342,631,313<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u7efc\u5408\u4e8f\u635f<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(93,981)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">190,167<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7d2f\u8ba1\u4e8f\u635f<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(178,833,259)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(226,476,058)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>156,558,713<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>112,684,122<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d1f\u503a\u548c\u80a1\u4e1c\u6743\u76ca\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\">&nbsp;<\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>189,510,726<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>178,557,472<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen4\" colspan=\"4\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u672a\u7ecf\u5ba1\u8ba1\u7684\u5408\u5e76\u5229\u6da6\u8868&nbsp;<\/b>\uff08\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"3\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen5\" colspan=\"3\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u81f3<\/b><b>6<\/b><b>\u670830\u65e5<\/b><b>\u7684<\/b><b>6\u4e2a\u6708<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2021<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2022<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6536\u5165<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6280\u672f\u8bb8\u53ef\u5408\u4f5c<\/span><span class=\"prnews_span\">\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">1,358,836<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">3,923,174<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8d39\u7528<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7814\u53d1\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(31,462,546)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(45,148,357)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7ba1\u7406\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(7,400,123)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(6,848,925)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u8425\u4e1a\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(37,503,833)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(48,074,108)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">69,332<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">14,931<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(192,866)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(211,434)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u6536\u5165<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">822,837<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">430,671<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6c47\u5151\u635f\u76ca<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(386,153)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">756,085<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7a0e\u524d\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(37,190,683)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,083,855)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6240\u5f97\u7a0e\u8d39\u7528<\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(558,944)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(37,190,683)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5176\u4ed6\u7efc\u5408\u6536\u76ca<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5916\u5e01\u62a5\u8868\u6298\u7b97\u5dee\u5f02<\/span><\/p>\n<\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">197,483<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">284,148<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7efc\u5408\u4e8f\u635f\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen12\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(36,993,200)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen12\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,358,651)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(37,190,683)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u53ef\u8f6c\u6362\u53ef\u8d4e\u56de\u4f18\u5148\u80a1\u589e\u52a0\u81f3\u53ef\u8d4e\u56de\u4ef7\u503c<\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(28,553)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5f52\u5c5e\u4e8e\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen12\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(37,219,236)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen12\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7528\u4e8e\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u635f\u5931\u7684\u52a0\u6743\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6570<\/b><b>:<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">45,514,701<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">45,514,701<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.82)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.87)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.82)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.87)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"0\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen4\" colspan=\"4\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08<\/b><b>GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"3\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prnpr2 prnpl2 prnvab prntac prnsbtb1 prnrbrb1 prnbbbs prnsblb1\" colspan=\"3\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u622a\u81f3<\/b><b>6<\/b><b>\u670830\u65e5<\/b><b>\u7684<\/b><b>6\u4e2a\u6708<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2021\u5e74<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>2022\u5e74<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">US$<\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b><span class=\"prnews_span\">US$<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u5f52\u5c5e\u4e8e\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(37,219,236)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(47,642,799)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8c03\u6574:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u6743\u6fc0\u52b1\u8d39\u7528&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">10,152,791<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,725,868<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u53ef\u8f6c\u6362\u53ef\u8d4e\u56de\u4f18\u5148\u80a1\u589e\u52a0\u81f3\u53ef\u8d4e\u56de\u4ef7\u503c<\/span><\/p>\n<\/td>\n<td class=\"prngen14\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">28,553<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen14\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u666e\u901a\u80a1\u80a1\u4e1c\u51c0\u4e8f\u635f\u603b\u989d<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen15\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(27,037,892)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen15\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(41,916,931)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7528\u4e8e\u8ba1\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u635f\u5931\u7684\u52a0\u6743\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6570\uff1a<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">45,514,701<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">45,514,701<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.59)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.77)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91ca\u540e<\/span><\/p>\n<\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.59)<\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.77)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; \u6297CTLA-4 \u65b0\u8868\u4f4d\u6297\u4f53&nbsp;ADG116\u7684\u5173\u952e\u65b0\u6570\u636e\uff0c\u8be5\u6297\u4f53\u5728\u5355\u4e00\u7597\u6cd5\u4ee5\u53ca\u4e0e\u6297&nbsp;PD-1\u7684\u8054\u5408\u7597\u6cd5\u4e2d\u5c55\u73b0\u51fa\u5f15\u4eba\u6ce8\u76ee\u7684\u5b89\u5168\u6027\u53ca\u80bf\u7624\u5b8c\u5168\u548c\u90e8\u5206\u6536\u7f29\u7684\u4e34\u5e8a\u7597\u6548\uff1b\u76f8\u5173\u6570\u636e\u5c06\u57282022\u5e74\u7f8e\u56fd\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a\uff08SITC\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03 \u2013 &#8211; 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