{"id":77732,"date":"2022-08-29T14:42:00","date_gmt":"2022-08-29T07:42:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082914420077732"},"modified":"2022-08-29T22:15:06","modified_gmt":"2022-08-29T14:15:06","slug":"sirnaomics%e6%a0%b8%e5%bf%83%e4%ba%a7%e5%93%81stp705%e5%9c%a8%e6%b2%bb%e7%96%97%e7%9a%ae%e8%82%a4%e5%9f%ba%e5%ba%95%e7%bb%86%e8%83%9e%e7%99%8cii%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%bb%84","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082914420077732","title":{"rendered":"Sirnaomics\u6838\u5fc3\u4ea7\u54c1STP705\u5728\u6cbb\u7597\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ec4\u522b\u4e2d\u5b9e\u73b0100%\u5b8c\u5168\u6e05\u9664"},"content":{"rendered":"

\u6570\u636e\u663e\u793a\uff0c\u5728\u63a5\u53d7\u6cbb\u7597\u7684\u4e94\u540d\u53d7\u8bd5\u8005\u4e2d\uff0c\u65e0\u4e0d\u826f\u4e8b\u4ef6\uff0c\u663e\u793a\u826f\u597d\u7684\u5b89\u5168\u6027\u3002
<\/i>\u516c\u53f8\u76ee\u524d\u6b63\u5728\u7ee7\u7eed\u8fdb\u884c\u5242\u91cf\u722c\u5761<\/i>II<\/i>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u5c55\u5f00\u5242\u91cf\u7814\u7a76<\/i><\/p>\n

\u9a6c\u91cc\u5170\u5dde\u76d6\u745f\u65af\u5821\u5e02\u548c\u4e2d\u56fd\u82cf\u5dde2022\u5e748\u670829\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — Sirnaomics Ltd.\uff08"\u516c\u53f8<\/b>"\uff0c"Sirnaomics<\/b>"\uff0c\u80a1\u4efd\u4ee3\u53f7\uff1a2257.HK\uff09\uff0c\u662f\u4e00\u5bb6\u884c\u4e1a\u9886\u5148\u7684\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1RNAi\u7597\u6cd5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Sirnaomics\u5ba3\u5e03STP705\u5728\u6cbb\u7597\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\uff08BCC\uff09\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7180\u03bcg\u5242\u91cf\u7ed9\u836f\u7684\u961f\u5217\u5b9e\u73b0100%\u5b8c\u5168\u6e05\u9664\uff08CR\uff09\uff0c\u8868\u660e\u8be5\u7597\u6cd5\u5177\u6709\u826f\u597d\u7684\u53ef\u884c\u6027\u3002STP705\u662f\u4e00\u79cdsiRNA\uff08\u5c0f\u5e72\u6270\u6838\u9178\uff09\u7597\u6cd5\uff0c\u662f\u7531\u4e24\u4e2asiRNA\u5be1\u6838\u82f7\u9178\u7ec4\u6210\u7684TGF-\u03b21\/COX-2\u53cc\u9776\u70b9\u6291\u5236\u5242\u3002<\/p>\n

\u9664\u4e86\u5b9e\u73b0100%\u7684\u5b8c\u5168\u6e05\u9664\uff08CR\uff09\u5916\uff0c\u961f\u5217\u4e2d5\u540d\u53d7\u8bd5\u8005\u8fd8\u663e\u793a\u51fa\u7a33\u5b9a\u7684\u6216\u66f4\u4f18\u7684\u7f8e\u5bb9\u6548\u679c\uff0c\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\uff08\u65e0\u4e0d\u826f\u4e8b\u4ef6\uff09\u4e14\u6ca1\u6709\u660e\u663e\u7684\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\u3002\u516c\u53f8\u76ee\u524d\u6b63\u5728\u7ee7\u7eed\u8fdb\u884c\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\u4ee5\u5c55\u5f00\u5242\u91cf\u7814\u7a76\uff0c\u9884\u8ba12023\u5e74\u7b2c\u4e00\u5b63\u5ea6\u83b7\u5f97\u6700\u7ec8\u62a5\u544a\u3002<\/p>\n

Sirnaomics\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001\u6267\u884c\u8463\u4e8b\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u9646\u9633\u535a\u58eb\u8868\u793a\uff1a"STP705\u6cbb\u7597BCC\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u7ed3\u679c\u663e\u793a\u4e86\u60ca\u4eba\u7684\u7597\u6548\uff0c\u6ca1\u6709\u51fa\u73b0\u4efb\u4f55\u836f\u7269\u76f8\u5173\u7684AEs\u548cSAEs\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86STP705\u5728\u6cbb\u7597\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\u53ca\u5176\u4ed6\u9886\u57df\u7684\u5de8\u5927\u6f5c\u529b\u3002\u57fa\u4e8e\u5176\u5728BCC\u548c\u76ae\u80a4\u539f\u4f4d\u9cde\u72b6\u7ec6\u80de\u764c\uff08isSCC\uff09\u4e34\u5e8a\u7814\u7a76\u7684\u6210\u529f\uff0cSirnaomics\u6b63\u7740\u624b\u7814\u53d1\u9002\u7528\u4e8e\u5404\u79cd\u7c7b\u578b\u764c\u75c7\u7684\u521b\u65b0\u591a\u80bdsiRNA\u7597\u6cd5\u3002"<\/p>\n

"\u5b9e\u73b0100%\u5b8c\u5168\u6e05\u9664\u6e05\u6670\u5730\u8868\u660e\uff0c\u6211\u4eec\u7684\u7597\u6cd5\u6709\u53ef\u80fd\u66ff\u4ee3\u73b0\u6709\u6cbb\u7597\u65b9\u6848\uff0c\u5982\u5916\u79d1\u624b\u672f\u5207\u9664\u75c5\u7076\uff0c\u6210\u4e3a\u60a3\u8005\u65b0\u7684\u9009\u62e9\u3002"Sirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u52a1\u5b98Michael Molyneaux\u535a\u58eb\u8bf4\u9053\uff0c"\u76f8\u6bd4\u8d77\u624b\u672f\u6cbb\u7597\u65b9\u6cd5\uff0cSTP705\u53ef\u964d\u4f4e\u75a4\u75d5\u7387\u5e76\u8fbe\u5230\u66f4\u4f18\u7684\u7f8e\u5bb9\u6548\u679c\uff0c\u5bf9\u4e8eBCC\u548c\u5176\u4ed6\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u4f18\u52bf\u3002"<\/p>\n

\u672c\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u722c\u5761\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u672a\u6765\u5c06\u589e\u52a0\u8bd5\u9a8c\u7ec4\u522b\u7684\u6570\u91cf\u4ee5\u8fdb\u4e00\u6b65\u8bc4\u4f30\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c\uff08BCC\uff09\u60a3\u8005\u5728\u5c40\u90e8\u6ce8\u5c04\u4e0d\u540c\u5242\u91cfSTP705\u540e\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u53ca\u6709\u6548\u6027\u3002\u5982\u6b32\u4e86\u89e3\u6709\u5173\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5176\u4ed6\u76f8\u5173\u4fe1\u606f\uff0c\u8bf7\u6d4f\u89c8clinicaltrials.gov\uff0c\u8bc6\u522b\u7801\uff1aNCT04669808\u3002<\/p>\n

\u5173\u4e8e\u57fa\u5e95\u7ec6\u80de\u764c
<\/b>\u57fa\u5e95\u7ec6\u80de\u764c\uff08BCC\uff09\u662f\u4e00\u79cd\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\uff08NMSC\uff09\uff0c\u5176\u5f62\u6210\u539f\u56e0\u4e0e\u9633\u5149\u7684\u7d2b\u5916\u7ebf\u8f90\u5c04\u6709\u5173\u3002\u57fa\u5e95\u7ec6\u80de\u764c\u662f\u9664\u9cde\u72b6\u7ec6\u80de\u764c\uff08SCC\uff09\u4ee5\u5916\u6700\u5e38\u89c1\u7684\u76ae\u80a4\u764c\u5f62\u5f0f\uff0c\u867d\u7136\u5b83\u4eec\u8f6c\u79fb\u7387\u8f83\u4f4e\uff0c\u4f46\u5b58\u5728\u5c40\u90e8\u4fb5\u88ad\u6027\u5e76\u7834\u574f\u76ae\u80a4\u548c\u5468\u56f4\u7ed3\u6784\u7684\u53ef\u80fd\u6027\u3002\u57fa\u5e95\u7ec6\u80de\u764c\u8f6c\u79fb\u7387\u7ea6\u4e3a0.0029%\u548c0.55%\u4e4b\u95f4\uff0c\u5e38\u89c1\u7684\u8f6c\u79fb\u90e8\u4f4d\u4e3a\u533a\u57df\u6dcb\u5df4\u7ed3\u3001\u80ba\u90e8\u3001\u9aa8\u9abc\u3001\u76ae\u80a4\u4e0e\u809d\u810f\u3002\u6839\u636e\u300a2012\u5e74\u7f8e\u56fd\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\uff08\u89d2\u8d28\u7ec6\u80de\u764c\uff09\u7684\u53d1\u75c5\u7387\u4f30\u8ba1\u300b\uff08Incidence Estimate of Nonmelanoma Skin Cancer\uff08Keratinocyte Carcinomas\uff09\uff092020\u5e74\u7f8e\u56fd\u65b0\u589e\u57fa\u5e95\u7ec6\u80de\u764c\u60a3\u8005\u4eba\u6570\u4e3a240\u4e07\uff0c\u9884\u8ba12030\u5e74\u8fd9\u4e00\u6570\u5b57\u5c06\u589e\u81f3420\u4e07\u3002\u57fa\u5e95\u7ec6\u80de\u764c\u5e38\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u4e3a\u666e\u901a\u5916\u79d1\u624b\u672f\u3001\u83ab\u6c0f\u663e\u5fae\u56fe\u50cf\u624b\u672f\u3001\u8f6f\u818f\u5c40\u90e8\u6cbb\u7597\u3001\u51b7\u7597\u3001\u956d\u5c04\u3001\u7535\u5207\u548c\u653e\u5c04\u6cbb\u7597\u3002\u5404\u79cd\u5f62\u5f0f\u7684\u5916\u79d1\u624b\u672f\u4f1a\u5e26\u6765\u660e\u663e\u7684\u76ae\u80a4\u4e0d\u826f\u4e8b\u4ef6\uff1a\u8bf8\u5982\u75a4\u75d5\u3001\u611f\u67d3\u548c\u51fa\u8840\u7b49\u98ce\u9669\u3002\u76ee\u524d\u53ea\u6709\u4e24\u6b3e\u836f\u7269\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7528\u4e8e\u8f6c\u79fb\u524d\u7684\u57fa\u5e95\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u4f46\u90e8\u5206\u60a3\u8005\u4e2d\u4ecd\u7136\u51fa\u73b0\u76ae\u80a4\u53cd\u5e94\u3002<\/p>\n

\u76ee\u524dSTP705\u5728\u9488\u5bf9\u57fa\u5e95\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u4e2d\u663e\u793a\uff0c\u5176\u6709\u5229\u4e8e\u60a3\u8005\u5916\u8868\u7f8e\u89c2\uff0c\u5c24\u5176\u662f\u5934\u90e8\u3001\u9762\u90e8\u6216\u9888\u90e8\u6709\u75c5\u53d8\u7684\u60a3\u8005\u3002\u4e34\u5e8a\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u76ee\u524d\u53ef\u7528\u7684\u5c40\u90e8\u7597\u6cd5\u76f8\u6bd4\uff0cSTP705\u53ef\u5b9e\u73b0\u66f4\u9ad8\u7684\u5b8c\u5168\u6e05\u9664\u7387\u3002<\/p>\n

\u5173\u4e8e<\/b>STP705
<\/b>Sirnaomics\u7684\u4e3b\u8981\u5019\u9009\u4ea7\u54c1STP705\u662f\u4e00\u79cdsiRNA\uff08\u5c0f\u5e72\u6270\u6838\u9178\uff09\u7597\u6cd5\uff0c\u5229\u7528\u53cc\u9776\u5411\u6291\u5236\u7279\u6027\u548c\u591a\u80bd\u7eb3\u7c73\u9897\u7c92\uff08PNP\uff09\u589e\u5f3a\u9012\u9001\u6765\u76f4\u63a5\u6572\u4f4eTGF-\u03b21\u548cCOX-2\u57fa\u56e0\u8868\u8fbe\u3002\u8be5\u5019\u9009\u4ea7\u54c1\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u548c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u591a\u9879IND\u6279\u51c6\uff0c\u5305\u62ec\u7528\u4e8e\u6cbb\u7597\u80c6\u7ba1\u764c\u3001\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u80a4\u764c\u548c\u589e\u751f\u6027\u7622\u75d5\u3002STP705\u8fd8\u83b7\u5f97\u4e86\u6cbb\u7597\u80c6\u7ba1\u764c\u548c\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002STP705\u76ee\u524d\u9488\u5bf9\u4e0d\u540c\u7684\u9002\u5e94\u75c7\u8fdb\u884c\u4e86\u4e03\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff1a\u4e00\u9879\u9488\u5bf9\u9cde\u72b6\u7ec6\u80de\u539f\u4f4d\u764c\uff08isSCC\uff09\u7684IIb\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e00\u9879\u6cbb\u7597\u57fa\u5e95\u7ec6\u80de\u764c\uff08BCC\uff09\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e00\u9879\u6cbb\u7597\u7622\u75d5\u7599\u7629\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e00\u9879\u6cbb\u7597\u589e\u751f\u6027\u7622\u75d5\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e00\u9879\u6cbb\u7597\u9762\u90e8isSCC\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e00\u9879\u6cbb\u7597\u809d\u764c\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u53ca\u4e00\u9879\u7528\u4e8e\u533b\u5b66\u7f8e\u5bb9\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u5173\u4e8e<\/b>Sirnaomics
<\/b>Sirnaomics\u662f\u4e00\u5bb6RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u5019\u9009\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u524d\u53ca\u4e34\u5e8a\u9636\u6bb5\uff0c\u4e13\u6ce8\u4e8e\u63a2\u7d22\u53ca\u5f00\u53d1\u521b\u65b0\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u533b\u7597\u9700\u6c42\u53ca\u5e9e\u5927\u5e02\u573a\u673a\u4f1a\u7684\u9002\u5e94\u75c7\u3002Sirnaomics\u662f\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5747\u62e5\u6709\u91cd\u8981\u5e02\u573a\u5730\u4f4d\u7684\u9996\u5bb6\u4e34\u5e8a\u9636\u6bb5RNA\u7597\u6cd5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e14\u662f\u9996\u5bb6\u5c06\u5176\u6838\u5fc3\u4ea7\u54c1STP705\u7684RNAi\u7597\u6cd5\u5728\u80bf\u7624\u5b66\u9886\u57df\u53d6\u5f97\u79ef\u6781IIa\u671f\u4e34\u5e8a\u7ed3\u679c\u7684\u516c\u53f8\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u516c\u53f8\u8d44\u8baf\uff0c\u53ef\u6d4f\u89c8\uff1awww.sirnaomics.com<\/a>\u3002<\/p>\n

\u8054\u7cfb\u65b9\u5f0f\uff1a
<\/b>Michael Molyneaux<\/span>, MD, MBA 
Sirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u7597\u5b98 
\u7535\u90ae\uff1aMichaelMolyneaux@sirnaomics.com<\/a> <\/p>\n

\u6295\u8d44\u8005\u67e5\u8be2\uff1a
<\/b>\u53f6\u6c38\u57fa 
Sirnaomics\u4e2d\u56fd\u9996\u5e2d\u8d22\u52a1\u5b98 
\u7535\u90ae\uff1aNigelYip@sirnaomics.com<\/a><\/p>\n

\u7f8e\u56fd\u4f20\u5a92\u67e5\u8be2\uff1a
<\/b>Mark Corbae<\/span>
\u7535\u8bdd\uff1a+1 203 682 8288
\u7535\u90ae\uff1aMark.Corbae@westwicke.com<\/a> <\/p>\n

\u4e9a\u6d32\u4f20\u5a92\u67e5\u8be2\uff1a
<\/b>\u674e\u8000\u8363
\u7535\u8bdd\uff1a+852 3150 6707
\u7535\u90ae\uff1asirnaomics.hk@pordahavas.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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Molyneaux, MD, MBA Sirnaomics\u6267\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u533b\u7597\u5b98 \u7535\u90ae\uff1aMichaelMolyneaux@sirnaomics.com  \u6295\u8d44\u8005\u67e5\u8be2\uff1a\u53f6\u6c38\u57fa Sirnaomics\u4e2d\u56fd\u9996\u5e2d\u8d22\u52a1\u5b98 \u7535\u90ae\uff1aNigelYip@sirnaomics.com \u7f8e\u56fd\u4f20\u5a92\u67e5\u8be2\uff1aMark Corbae\u7535\u8bdd\uff1a+1 203 682 8288\u7535\u90ae\uff1aMark.Corbae@westwicke.com  \u4e9a\u6d32\u4f20\u5a92\u67e5\u8be2\uff1a\u674e\u8000\u8363\u7535\u8bdd\uff1a+852 3150 6707\u7535\u90ae\uff1asirnaomics.hk@pordahavas.com… Read 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