{"id":77142,"date":"2022-08-24T20:10:00","date_gmt":"2022-08-24T13:10:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082420100077142"},"modified":"2022-08-24T22:13:52","modified_gmt":"2022-08-24T14:13:52","slug":"%e4%ba%91%e9%a1%b6%e6%96%b0%e8%80%80%e5%85%ac%e5%b8%832022%e5%b9%b4%e4%b8%8a%e5%8d%8a%e5%b9%b4%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082420100077142","title":{"rendered":"\u4e91\u9876\u65b0\u8000\u516c\u5e032022\u5e74\u4e0a\u534a\u5e74\u4e1a\u7ee9"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span>, <span class=\"legendSpanClass\">2022\u5e748\u670824\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;<a href=\"https:\/\/www.everestmedicines.com\/\" target=\"_blank\" rel=\"nofollow noopener\">\u4e91\u9876\u65b0\u8000<\/a>\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u592a\u5e02\u573a\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u4eca\u65e5\u516c\u5e032022\u5e74\u4e0a\u534a\u5e74\u4e1a\u7ee9\u53ca\u4e1a\u52a1\u8fdb\u5c55\u3002<\/p>\n<p>2022\u5e74\u4e0a\u534a\u5e74\uff0c\u4e91\u9876\u65b0\u8000\u5728\u4e1a\u52a1\u548c\u6cbb\u7597\u9886\u57df\u7684\u5404\u4e2a\u65b9\u9762\u90fd\u53d6\u5f97\u4e86\u957f\u8db3\u8fdb\u5c55\uff0c\u516c\u53f8\u6301\u7eed\u5728\u6211\u4eec\u591a\u6837\u5316\u7684\u4ea7\u54c1\u7ba1\u7ebf\u4e2d\u63a8\u8fdb\u4e34\u5e8a\u5f00\u53d1\u548c\u4e0a\u5e02\u5ba1\u6279\uff0c\u5efa\u7acb\u81ea\u4e3b\u7814\u53d1\u80fd\u529b\u5e76\u6269\u5927\u91cd\u8981\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u3002\u5c55\u671b\u672a\u6765\uff0c\u4e91\u9876\u65b0\u8000\u901a\u8fc7\u8fd1\u671f\u6218\u7565\u6027\u51fa\u552e\u62d3\u8fbe\u7ef4\u5728\u4e9a\u6d32\u5730\u533a\u7684\u6743\u76ca\u52a0\u5f3a\u4e86\u8d22\u52a1\u72b6\u51b5\u3001\u4f18\u5316\u4e86\u8d44\u6e90\u914d\u7f6e\uff0c\u516c\u53f8\u5c06\u52a0\u901f\u5f00\u53d1\u6211\u4eec\u4ea7\u54c1\u7ec4\u5408\u4e2d\u5177\u6709\u540c\u7c7b\u9996\u521b\u6216\u540c\u7c7b\u9886\u5148\u6f5c\u529b\u7684\u91cd\u8981\u8d44\u4ea7\uff0c\u8fdb\u4e00\u6b65\u63a8\u8fdb\u6211\u4eec\u7684\u81ea\u7814\u80fd\u529b\uff0c\u5e76\u5bfb\u6c42\u66f4\u591a\u7684\u4e1a\u52a1\u53d1\u5c55\u673a\u4f1a\uff0c\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u4e3a\u5168\u7403\u60a3\u8005\u548c\u80a1\u4e1c\u521b\u9020\u957f\u671f\u4ef7\u503c\u3002\u4ee5\u4e0b\u4e3a\u4e0a\u534a\u5e74\u7684\u4ea7\u54c1\u4eae\u70b9\u53ca\u672a\u6765\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p><b>NEFECON<\/b><b>\uff08<\/b><b>Tarpeyo<sup>TM<\/sup><\/b><b>\uff09\u662f\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027\u514d\u75ab\u7403\u86cb\u767d<\/b><b>A<\/b><b>\u80be\u75c5\uff08<\/b><b>IgAN<\/b><b>\uff09\u7684\u65b0\u578b\u53e3\u670d\u9776\u5411\u5e03\u5730\u5948\u5fb7\u8fdf\u91ca\u80f6\u56ca<\/b><\/p>\n<p>&#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55:<\/p>\n<ul type=\"disc\">\n<li>2022\u5e743\u6708\uff0c\u672c\u516c\u53f8\u4e0eCalliditas\u7b7e\u8ba2\u6388\u6743\u534f\u8bae\uff0c\u4ee5\u5728\u97e9\u56fd\u5f00\u53d1\u53ca\u5546\u4e1a\u5316NEFECON\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027IgAN\uff0c\u6269\u5927\u4e86\u73b0\u6709\u5728\u5927\u4e2d\u534e\u533a\u53ca\u65b0\u52a0\u5761\u7684\u8bb8\u53ef\u6743\u3002\u8be5\u4ea4\u6613\u6807\u5fd7\u7740\u672c\u516c\u53f8\u4e3a\u8fdb\u4e00\u6b65\u6269\u5927\u5176\u56fd\u9645\u5546\u4e1a\u7248\u56fe\u800c\u4f5c\u51fa\u7684\u6700\u65b0\u52aa\u529b\u3002<\/li>\n<li>2022\u5e744\u6708\uff0c\u672c\u516c\u53f8\u5ba3\u5e03\uff0c\u7ecfNEFECON\u6cbb\u7597\u4e5d\u4e2a\u6708\u540e\u4e2d\u56fd\u4e9a\u7ec4\u86cb\u767d\u5c3f\u4e0b\u964d\u53caeGFR\u7a33\u5b9a\u7684\u7ed3\u679c\u4e0eCalliditas Therapeutics AB\u4e8e2020\u5e7411\u6708\u516c\u5e03\u7684NefIgArd\u5173\u952e\u6027\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8cA\u90e8\u5206\u7684\u9876\u7ebf\u7ed3\u679c\u4e00\u81f4\u3002<\/li>\n<\/ul>\n<p>&#8211; \u62a5\u544a\u671f\u540e\u6210\u5c31\u53ca\u9884\u671f\u91cc\u7a0b\u7891:<\/p>\n<ul type=\"disc\">\n<li>2022\u5e747\u6708\uff0c\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34Calliditas\u5c31Kinpeygo<sup>&reg;<\/sup>\uff08\u7814\u53d1\u540d\u79f0\u4e3aNEFECON\uff09\u5df2\u83b7\u6b27\u76df\u59d4\u5458\u4f1a\u9644\u6761\u4ef6\u4e0a\u5e02\u8bb8\u53ef\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u5177\u6709\u5feb\u901f\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\uff08\u5c3f\u86cb\u767d\u4e0e\u808c\u9150\u6bd4\uff08UPCR)\uff09\u2265 1.5\u514b\/\u514b\uff09\u7684\u539f\u53d1\u6027IgAN\u6210\u4eba\u60a3\u8005\u3002<\/li>\n<li>\u6211\u4eec\u9884\u671f\u5c06\u4e8e2022\u5e74\u4e0b\u534a\u5e74\u5728\u4e2d\u56fd\u5c31NEFECON\u7528\u4e8e\u539f\u53d1\u6027IgAN\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002<\/li>\n<\/ul>\n<p><b>Etrasimod<\/b><b>\u662f\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08<\/b><b>UC<\/b><b>\uff09\u7684\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u9009\u62e9\u6027\u9798\u6c28\u9187<\/b><b>-1-<\/b><b>\u78f7\u9178\uff08<\/b><b>S1P<\/b><b>\uff09\u53d7\u4f53\u8c03\u8282\u5242<\/b><\/p>\n<p>&#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55:<\/p>\n<ul type=\"disc\">\n<li>2022\u5e745\u6708\uff0c\u6211\u4eec\u7684\u6388\u6743\u5408\u4f5c\u4f19\u4f34\u8f89\u745e\u516c\u53f8\u516c\u5e03\u4e86ELEVATE UC 3\u671f\u6ce8\u518c\u7814\u7a76\u4e0b\u4e24\u9879\u5173\u952e\u6027\u8bd5\u9a8c\u7684\u8be6\u7ec6\u7ed3\u679c\uff0c\u7814\u7a76\u8bc4\u4f30\u4e86\u9009\u62e9\u6027\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u53d7\u4f53\u8c03\u8282\u5242etrasimod\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u6548\u679c\u3002\u8fd9\u4e24\u98793\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\u5747\u8fbe\u5230\u6240\u6709\u4e3b\u8981\u53ca\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u4e14etrasimod\u663e\u793a\u51fa\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u7684\u5b89\u5168\u6027\u3002\u5728\u4e3a\u671f52\u5468\u7684ELEVATE UC 52\u7814\u7a76\u4e2d\uff0c\u7b2c12\u5468\u65f6\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a27.0%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a7.4%\uff08\u5dee\u5f02\u4e3a19.8%\uff0cP = &lt;.001\uff09\uff1b \u7b2c52\u5468\u65f6\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a32.1%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a6.7%\uff08\u5dee\u5f02\u4e3a25.4%\uff0cP = &lt;.001\uff09\u3002\u5728\u4e3a\u671f12\u5468\u7684ELEVATE UC 12\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a24.8%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a15.2%\uff08\u5dee\u5f02\u4e3a9.7%\uff0cP = .0264\uff09\u3002ELEVATE UC 52\u53caUC 12\u7814\u7a76\u5f97\u51fa\u7684\u6570\u636e\u5c06\u4f5c\u4e3a\u7528\u4e8e\u76d1\u7ba1\u7533\u8bf7\u7684\u6570\u636e\u57fa\u7840\uff0c\u8f89\u745e\u9884\u671f\u5c06\u4e8e\u4eca\u5e74\u7a0d\u540e\u542f\u52a8\u6709\u5173\u7a0b\u5e8f\u3002<\/li>\n<\/ul>\n<p>&#8211; \u62a5\u544a\u671f\u540e\u6210\u5c31\u53ca\u9884\u671f\u91cc\u7a0b\u7891<span id=\"spanHghltf8bf\">:<\/span><\/p>\n<ul type=\"disc\">\n<li>\u6211\u4eec\u6b63\u5728\u5f00\u5c55etrasimod\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6UC\u76843\u671f\u7814\u7a76\uff0c\u9884\u671f\u5c06\u4e8e2023\u5e74\u5b8c\u6210\u60a3\u8005\u62db\u52df\u3002<\/li>\n<\/ul>\n<p><b>PTX-COVID19<\/b><b>\u4e3a\u4e00\u79cd\u7531\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u914d\u5236\u5e76\u5177\u6709\u8f83\u5f3a\u514d\u75ab\u539f\u6027\u53ca\u8010\u53d7\u6027\u7684\u6f5c\u5728\u540c\u7c7b\u9886\u5148mRNA COVID-19<\/b><b>\u75ab\u82d7<\/b><\/p>\n<p>&#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55:<\/p>\n<ul type=\"disc\">\n<li>2022\u5e744\u6708\uff0c\u672c\u516c\u53f8\u5c31\u8bbe\u7acb\u5408\u4f19\u4f01\u4e1a\u4e0e\u534e\u6da6\u533b\u836f\u96c6\u56e2\u6709\u9650\u516c\u53f8\u7b7e\u8ba2\u5408\u4f5c\u5907\u5fd8\u5f55\uff0c\u62df\u6210\u7acb\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u53d1\u73b0\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178\uff08mRNA\uff09\u75ab\u82d7\u7684\u72ec\u7acb\u516c\u53f8\u3002\u4e0e\u534e\u6da6\u533b\u836f\u8ba1\u5212\u4e2d\u7684\u5408\u4f5c\uff0c\u5c06\u4e3amRNA\u516c\u53f8\u8fdb\u4e00\u6b65\u53d1\u5c55\u53d6\u5f97\u4f18\u52bf\uff0c\u901a\u8fc7\u5728\u6ce8\u518c\u3001\u5546\u4e1a\u5316\u7b49\u9886\u57df\u7684\u5408\u4f5c\uff0c\u6709\u529b\u63a8\u8fdb\u6211\u4eec\u6709\u540c\u7c7b\u9886\u5148\u6f5c\u529b\u7684mRNA\u5019\u9009\u75ab\u82d7\u5728\u4e2d\u56fd\u7684\u5f00\u53d1\u8fdb\u5ea6\u3002\u6839\u636e\u5408\u4f5c\u5907\u5fd8\u5f55\u7684\u6761\u6b3e\uff0cmRNA\u516c\u53f8\u5c06\u6210\u4e3a\u4e00\u5bb6\u72ec\u7acb\u8fd0\u8425\u7684\u516c\u53f8\uff0c\u63a5\u7ba1\u672c\u516c\u53f8\u4e0eProvidence Therapeutics Holdings Inc.\uff08Providence\uff09\u5df2\u7b7e\u7f72\u7684\u5408\u4f5c\u534f\u8bae\u4e2d\u7684\u6743\u5229\uff0c\u5305\u62ec\u5b8c\u6574\u7684\u6280\u672f\u5e73\u53f0\uff0c\u4ee5\u53ca\u672c\u516c\u53f8\u7684mRNA\u751f\u4ea7\u8bbe\u65bd\u3002\u672c\u516c\u53f8\u5c06\u6210\u4e3amRNA\u516c\u53f8\u7684\u4e3b\u8981\u53ca\u63a7\u80a1\u80a1\u4e1c\u3002<\/li>\n<\/ul>\n<p>&#8211; \u62a5\u544a\u671f\u540e\u6210\u5c31\u53ca\u9884\u671f\u91cc\u7a0b\u7891:<\/p>\n<ul type=\"disc\">\n<li>Providence\u5c06\u57282022\u5e74\u516c\u5e03PTX-COVID19-B\u7684\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u6570\u636e\u3002<\/li>\n<li>Providence\u53ca\u672c\u516c\u53f8\u5c06\u4e8e2022\u5e74\u542f\u52a8PTX-COVID19-B\u52a0\u5f3a\u9488\u9002\u5e94\u75c7\u76843\u671f\u8bd5\u9a8c\u3002<\/li>\n<li>Providence\u53ca\u672c\u516c\u53f8\u6b63\u5728\u7814\u7a76\u4e00\u79cd\u9488\u5bf9\u5965\u5bc6\u514b\u620e\uff08Omicron\uff09\u7684\u4e8c\u4ef7\u52a0\u5f3a\u9488\u5019\u9009\u75ab\u82d7EVER-COVID19-M1\uff0c\u5e76\u9884\u671f\u5c06\u4e8e2023\u5e74\u4e0a\u534a\u5e74\u5c313\u671f\u6ce8\u518c\u6027\u7814\u7a76\u63d0\u4ea4\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u3002<\/li>\n<li>Providence\u53ca\u672c\u516c\u53f8\u9884\u671f\u5c06\u81ea2023\u5e74\u8d77\u5f00\u59cb\u5728\u5168\u7403\u8303\u56f4\u5c31mRNA COVID-19\u75ab\u82d7\u6eda\u52a8\u63d0\u4ea4\u76d1\u7ba1\u6587\u4ef6\uff0c\u5e76\u9884\u671f\u4e8e2023\u5e74\u83b7\u5f97\u6279\u51c6\u5e76\u4e0a\u5e02\u3002<\/li>\n<\/ul>\n<p><b>\u62d3\u8fbe\u7ef4<\/b><sup><b>&reg;<\/b><\/sup><b>\uff08\u82f1\u6587\u5546\u54c1\u540d\u4e3a<\/b><b>Trodelvy<sup>&reg;<\/sup><\/b><b>\uff0c\u6208\u6c99\u59a5\u73e0\u5355\u6297\uff09\u662f\u540c\u7c7b\u9996\u521b\u7684<\/b><b>TROP-2<\/b><b>\u9776\u5411\u6297\u4f53\u5076\u8054\u836f\u7269\uff08<\/b><b>ADC<\/b><b>\uff09\u4ea7\u54c1<\/b><\/p>\n<p>&#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55\uff1a<\/p>\n<ul type=\"disc\">\n<li>2022\u5e741\u6708\uff0c\u672c\u516c\u53f8\u5ba3\u5e03\u5c06\u52a0\u5165\u5409\u5229\u5fb7\uff08Gilead\uff09\u4e0e\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u4e4b\u95f4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5408\u4f5c\u5f00\u5c55\u7684\u7814\u7a76\uff0c\u4ee5\u8bc4\u4f30Trodelvy\u4e0eMSD\u7684\u6297PD-1\u7597\u6cd5Keytruda<sup>&reg;<\/sup>\uff08pembrolizumab\uff09\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6cbb\u7597\u6548\u679c\u3002\u4f5c\u4e3a\u5408\u4f5c\u7684\u4e00\u90e8\u5206\uff0cMSD\u5c06\u652f\u6301\u8fd9\u9879\u7814\u7a76\u7684\u5f00\u5c55\u3002\u672c\u516c\u53f8\u5c06\u901a\u8fc7\u5176\u4e0e\u5409\u5229\u5fb7\u7684\u73b0\u6709\u5408\u4f5c\u534f\u8bae\u53c2\u4e0e\u8be5\u5168\u74033\u671f\u7814\u7a76\u7684\u4e9a\u6d32\u90e8\u5206\u3002<\/li>\n<li>2022\u5e741\u6708\uff0c\u65b0\u52a0\u5761\u536b\u751f\u79d1\u5b66\u5c40\uff08HSA\uff09\u6279\u51c6\u672c\u516c\u53f8Trodelvy\u7528\u4e8e\u6cbb\u7597\u4e8c\u7ebf\u53ca\u540e\u7ebf\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u3002<\/li>\n<li>2022\u5e743\u6708\uff0c\u672c\u516c\u53f8\u5411\u4e2d\u56fd\u9999\u6e2f\u7279\u522b\u884c\u653f\u533a\u536b\u751f\u7f72\u63d0\u4ea4Trodelvy\u7528\u4e8e\u6cbb\u7597\u4e8c\u7ebf\u53ca\u540e\u7ebf\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684NDA\u3002<\/li>\n<li>2022\u5e746\u6708\uff0c\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34\u5409\u5229\u5fb7\u5f00\u5c55\u76843\u671fTROPiCS-02\u7814\u7a76\u7684\u4e3b\u8981\u5206\u6790\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0c\u8fd9\u9879\u7814\u7a76\u65e8\u5728\u8bc4\u4f30Trodelvy\u65e2\u5f80\u63a5\u53d7\u8fc7\u5185\u5206\u6ccc\u6cbb\u7597\u3001CDK4\/6\u6291\u5236\u5242\u548c\u4e8c\u5230\u56db\u7ebf\u5316\u7597\u7b49\u9ad8\u5f3a\u5ea6\u6cbb\u7597\u7684\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2\u9634\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08HR+\/HER2- mBC\uff09\u60a3\u8005\u4e2d\u76f8\u6bd4\u533b\u751f\u9009\u62e9\u7684\u6807\u51c6\u5316\u7597\uff08TPC\uff09\u7684\u7597\u6548\u3002\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u663e\u8457\u964d\u4f4e34%\uff08\u4e2d\u4f4dPFS 5.5\u4e2a\u6708\u5bf9\u6bd44\u4e2a\u6708\uff1bHR\uff1a0.66\uff1b95% CI\uff1a0.53\u20130.83\uff1bP&lt;0.0003\uff09\u3002<\/li>\n<li>2022\u5e746\u6708\uff0c\u672c\u516c\u53f8\u5ba3\u5e03\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u6279\u51c6Trodelvy\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u4e8c\u7ebf\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u6210\u5e74\u60a3\u8005\u3002\u8fd9\u662f\u672c\u516c\u53f8\u9996\u6b3e\u5728\u4e2d\u56fd\u83b7\u51c6\u4e0a\u5e02\u7684\u521b\u65b0\u836f\u54c1\uff0c\u5148\u524d\u56fd\u5bb6\u836f\u76d1\u5c40\u4e8e2021\u5e745\u6708\u53d7\u7406\u4e86\u672c\u516c\u53f8\u5c31Trodelvy\u63d0\u4ea4\u7684\u751f\u7269\u5236\u54c1\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u5e76\u6388\u4e88\u4f18\u5148\u5ba1\u8bc4\u3002<\/li>\n<li>2022\u5e748\u6708\uff0c\u672c\u516c\u53f8\u5ba3\u5e03\u4e0e\u5409\u5229\u5fb7\u7684\u5168\u8d44\u9644\u5c5e\u516c\u53f8Immunomedics, Inc. \u8fbe\u6210\u534f\u8bae\uff0c\u636e\u6b64\u534f\u8bae\uff0c\u4e91\u9876\u65b0\u8000\u628a\u5728\u5927\u4e2d\u534e\u5730\u533a\u3001\u97e9\u56fd\u3001\u65b0\u52a0\u5761\u3001\u5370\u5ea6\u5c3c\u897f\u4e9a\u3001\u83f2\u5f8b\u5bbe\u3001\u8d8a\u5357\u3001\u6cf0\u56fd\u3001\u9a6c\u6765\u897f\u4e9a\u53ca\u8499\u53e4\u56fd\u5f00\u53d1\u53ca\u5546\u4e1a\u5316Trodelvy\u7684\u72ec\u5bb6\u6743\u5229\u8f6c\u8ba9\u7ed9Immunomedics\u3002\u6839\u636e\u8be5\u534f\u8bae\u7684\u6761\u6b3e\uff0c\u672c\u516c\u53f8\u5c06\u6536\u5230\u603b\u989d\u4e3a4.55\u4ebf\u7f8e\u5143\u7684\u5bf9\u4ef7\uff0c\u5176\u4e2d\u5305\u62ec\u9884\u4ed8\u6b3e2.8\u4ebf\u7f8e\u5143\uff08\u9700\u83b7\u5f97\u76f8\u5173\u76d1\u7ba1\u90e8\u95e8\u7684\u6279\u51c6\uff09\uff0c\u4ee5\u53ca\u672a\u6765\u6f5c\u5728\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e1.75 \u4ebf\u7f8e\u5143\u3002\u6b64\u5916\uff0c\u672c\u516c\u53f8\u5c06\u65e0\u9700\u518d\u652f\u4ed82019\u5e744\u6708\u4e0eImmunomedics\u7b7e\u7f72\u7684\u6388\u6743\u8bb8\u53ef\u534f\u8bae\u4e2d\u5269\u4f59\u9ad8\u9650\u91cc\u7a0b\u7891\u4ed8\u6b3e7.1\u4ebf\u7f8e\u5143\uff0c\u4e0a\u8ff0\u539f\u534f\u8bae\u6388\u4e88\u4e86\u672c\u516c\u53f8\u5728\u5927\u4e2d\u534e\u533a\u3001\u97e9\u56fd\u548c\u5176\u4ed6\u7279\u5b9a\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u53d1\u3001\u6ce8\u518c\u548c\u5546\u4e1a\u5316Trodelvy<sup>&reg;<\/sup>\u7684\u6743\u5229\u3002\u6839\u636e\u8be5\u534f\u8bae\uff0c\u4ee5\u4e0a\u539f\u6388\u6743\u8bb8\u53ef\u534f\u8bae\u5c06\u88ab\u7ec8\u6b62\u3002<br \/>* TRODELVY\u5546\u6807\u7ecfGilead Sciences, Inc\u7684\u6388\u6743\u4f7f\u7528<\/li>\n<\/ul>\n<p><b>\u5176\u4ed6\u4e34\u5e8a\u9636\u6bb5\u8d44\u4ea7<\/b><\/p>\n<p>&#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55:<\/p>\n<ul type=\"disc\">\n<li>2022\u5e743\u6708\uff0c\u6211\u4eec\u7684\u6388\u6743\u5408\u4f5c\u4f19\u4f34Venatorx Pharmaceuticals\uff08Venatorx\uff09\u5f00\u5c55\u7684CERTAIN-1\u7814\u7a76\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\u3002CERTAIN-1\u662f\u4e00\u9879\u5173\u952e\u6027\u5168\u74033\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u5934\u5b62\u5421\u809f-Taniborbactam\uff0c\u4e00\u79cd\u5904\u4e8e\u7814\u7a76\u9636\u6bb5\u7684\u65b0\u836f\uff0c\u76f8\u6bd4\u7f8e\u7f57\u57f9\u5357\u4f5c\u4e3a\u6210\u4eba\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\uff08cUTI\uff09\u5305\u62ec\u6025\u6027\u80be\u76c2\u80be\u708e\u4f4f\u9662\u60a3\u8005\u7684\u4e00\u79cd\u6f5c\u5728\u6cbb\u7597\u836f\u7269\u3002\u8be5CERTAIN-1\u8bd5\u9a8c\u5168\u7403\u8303\u56f4\uff08\u5305\u62ec\u4e2d\u56fd\uff09\u5171\u5165\u7ec4661\u4f8b\u6210\u4eba\u60a3\u8005\uff0c\u4ed6\u4eec\u4ee52:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7\u5934\u5b62\u5421\u809f-taniborbactam\u6bcf8\u5c0f\u65f62.5\u514b\u6216\u7f8e\u7f57\u57f9\u5357\u6bcf8\u5c0f\u65f61\u514b\uff0c\u5171\u7ed9\u836f\u4e03\u5929\uff08\u83cc\u8840\u75c7\u60a3\u8005\u6700\u591a\u7ed9\u836f14\u5929\uff09\u3002\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u5373\u8bc4\u4ef7\u7597\u6548\u5224\u5b9a\uff08TOC\uff09\u8bbf\u89c6\u5728\u5fae\u751f\u7269\u5b66\u610f\u5411\u6cbb\u7597\uff08microITT\uff09\u4eba\u7fa4\u4e2d\u590d\u5408\u4e34\u5e8a\u548c\u5fae\u751f\u7269\u5b66\u7597\u6548\uff0c\u5934\u5b62\u5421\u809f-taniborbactam\u6cbb\u7597\u7ec4\u4e3a70.0%\uff0c\u7f8e\u7f57\u57f9\u5357\u6cbb\u7597\u7ec4\u4e3a58.0%\uff08\u6cbb\u7597\u5dee\u5171\u5f0211.9\uff1b95% CI\uff0c2.4\uff0c21.6\uff09\u5934\u5b62\u5421\u809f-Taniborbactam\u4e0e\u7f8e\u7f57\u57f9\u5357\u7ec4\u76f8\u6bd4\u5728\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u8fbe\u5230\u7edf\u8ba1\u5b66\u975e\u52a3\u6548\u6027\u3002Venatorx\u8ba1\u5212\u4e8e\u4eca\u5e74\u5c31\u5934\u5b62\u5421\u809f-taniborbactam\u7528\u4e8e\u6cbb\u7597cUTI\u4f4f\u9662\u6210\u5e74\u60a3\u8005\u5411FDA\u63d0\u4ea4NDA\u3002<\/li>\n<li>Ralinepag\u662f\u6f5c\u5728\u540c\u7c7b\u9886\u5148\u5177\u6709\u5f3a\u6548\u9009\u62e9\u6027\uff0c\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7ed9\u836f\u7684IP\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u80ba\u52a8\u8109\u9ad8\u538b\uff08PAH\uff09\u3002\u6211\u4eec\u7ee7\u7eed\u63a8\u8fdbPAH\u5728\u4e2d\u56fd\u76843\u671f\u6ce8\u518c\u8bd5\u9a8c\uff0c\u5176\u4e3a\u6211\u4eec\u4e0e\u5408\u4f5c\u4f19\u4f34United Therapeutics\u5171\u540c\u8fdb\u884c\u7684\u5168\u74033\u671f\u7814\u7a76\u7684\u4e00\u90e8\u5206\u3002<\/li>\n<\/ul>\n<p>&#8211; 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type=\"disc\">\n<li>2022\u5e741\u6708\uff0c\u6211\u4eec\u4e0e\u65b0\u52a0\u5761\u56fd\u5bb6\u836f\u7269\u53d1\u73b0\u53ca\u7814\u53d1\u5e73\u53f0\u5b9e\u9a8c\u836f\u7269\u5f00\u53d1\u4e2d\u5fc3\uff08EDDC\uff09\u7b7e\u8ba2\u4e86\u4e00\u9879\u5168\u7403\u8bb8\u53ef\u534f\u8bae\uff0c\u4ee5\u83b7\u5f97\u5728\u5168\u7403\u8303\u56f4\u5f00\u53d1\u3001\u5236\u9020\u53ca\u5546\u4e1a\u5316EDDC\u7684\u4e00\u7cfb\u5217\u75c5\u6bd23C\u72b6\uff083CL\uff09\u86cb\u767d\u9176\u6291\u5236\u5242\u7684\u72ec\u5bb6\u6743\u5229\uff0c\u4f5c\u4e3a\u9488\u5bf9SAR-CoV-2\uff08\u5bfc\u81f4COVID-19\u7684\u75c5\u6bd2\uff09\u53ca\u5176\u53d8\u5f02\u682a\u7684\u6f5c\u5728\u540c\u7c7b\u9886\u5148\u7684\u53e3\u670d\u6297\u75c5\u6bd2\u7597\u6cd5\u3002\u672c\u516c\u53f8\u5177\u6709\u8fdb\u4e00\u6b65\u8f6c\u6388\u6743\u8be5\u836f\u7269\u7684\u5168\u90e8\u6743\u5229\uff0c\u5e76\u5c06\u62e5\u6709\u5168\u9762\u6280\u672f\u8f6c\u8ba9\u3002<\/li>\n<li>EDDC-2214\u4f5c\u4e3a\u9488\u5bf9SAR-CoV-2\u53ca\u5176\u53d8\u5f02\u682a\u7684\u53e3\u670d\u6297\u75c5\u6bd2\u7597\u6cd5\uff0c\u6211\u4eec\u9884\u671f\u5c06\u4e8e2023\u5e74\u5f00\u5c55EDDC-2214\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<p><b>\u65b0\u836f\u5f00\u53d1<\/b><\/p>\n<ul type=\"disc\">\n<li>2022\u5e742\u6708\uff0c\u9996\u4e2a\u65b0\u836f\u7814\u53d1\u4e2d\u5fc3\u5728\u4e0a\u6d77\u5f20\u6c5f\u6b63\u5f0f\u843d\u6210\u542f\u7528\uff0c\u76ee\u524d\u5728\u80be\u75c5\u3001mRNA\u75ab\u82d7\u53ca\u80bf\u7624\u7b49\u591a\u4e2a\u6cbb\u7597\u9886\u57df\u5f00\u5c55\u8d85\u8fc710\u4e2a\u65b0\u836f\u7814\u53d1\u9879\u76ee\u3002<\/li>\n<li>\u6211\u4eec\u9884\u671f\u90e8\u5206\u81ea\u7814\u9879\u76ee\u5c06\u4e8e2023\u5e74\u8fdb\u5165\u63d0\u4ea4IND\u9636\u6bb5\u3002<\/li>\n<\/ul>\n<p><b>\u5546\u4e1a\u5316<\/b><\/p>\n<ul type=\"disc\">\n<li>\u6211\u4eec\u5df2\u7ec4\u5efa\u4e00\u652f\u884c\u4e1a\u9886\u5148\u7684\u5546\u4e1a\u5316\u56e2\u961f\uff0c\u4e3a\u6211\u4eec\u591a\u6b3e\u540e\u671f\u4ea7\u54c1\u7684\u672a\u6765\u5546\u4e1a\u4e0a\u5e02\u63d0\u4f9b\u652f\u6301\u3002 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type=\"disc\">\n<li>\u7814\u53d1\u5f00\u652f\u7531\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01250.8\u767e\u4e07\u5143\u589e\u52a0\u4eba\u6c11\u5e0194.7\u767e\u4e07\u5143\u81f3\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01345.5\u767e\u4e07\u5143\u3002\u8be5\u589e\u52a0\u4e3b\u8981\u7531\u4e8e(i)\u6211\u4eec\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u589e\u52a0\uff1b(ii)\u6269\u5927\u5185\u90e8\u65b0\u836f\u53d1\u73b0\u56e2\u961f\u4ee5\u6253\u9020\u5185\u90e8\u7814\u53d1\u80fd\u529b\uff1b\u53ca(iii)\u6211\u4eec\u5019\u9009\u836f\u7269\u7684\u6280\u672f\u8f6c\u8ba9\u8fc7\u7a0b\u4ea7\u751f\u7684\u6210\u672c\u589e\u52a0\u3002<\/li>\n<li>\u4e00\u822c\u53ca\u884c\u653f\u5f00\u652f\u7531\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01107.4\u767e\u4e07\u5143\u589e\u52a0\u4eba\u6c11\u5e0111.5\u767e\u4e07\u5143\u81f3\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01118.9\u767e\u4e07\u5143\u3002\u8be5\u589e\u52a0\u4e3b\u8981\u7531\u4e8e\u529e\u516c\u5ba4\u5f00\u652f\u53ca\u5176\u4ed6\u57fa\u7840\u8bbe\u65bd\u5f00\u652f\u7684\u589e\u52a0\u4ee5\u652f\u6301\u7ec4\u7ec7\u56e2\u961f\u6269\u5145\u3002<\/li>\n<li>\u5206\u9500\u53ca\u9500\u552e\u5f00\u652f\u7531\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e0142.1\u767e\u4e07\u5143\u589e\u52a0\u4eba\u6c11\u5e01106.1\u767e\u4e07\u5143\u81f3\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01148.2\u767e\u4e07\u5143\u3002\u8be5\u589e\u52a0\u4e3b\u8981\u7531\u4e8e\u6269\u5927\u5546\u4e1a\u7ec4\u7ec7\u4ee5\u53ca\u4e3a\u4ea7\u54c1\u5546\u4e1a\u5316\u8fdb\u884c\u4e0a\u5e02\u524d\u53ca\u4e0a\u5e02\u6d3b\u52a8\u6240\u81f4\u3002<\/li>\n<li>\u671f\u5185\u4e8f\u635f\u51c0\u989d\u7531\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01383.1\u767e\u4e07\u5143\u589e\u52a0\u4eba\u6c11\u5e01284.9\u767e\u4e07\u5143\u81f3\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01668.0\u767e\u4e07\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u7814\u53d1\u5f00\u652f\u4ee5\u53ca\u5206\u9500\u53ca\u9500\u552e\u5f00\u652f\u589e\u52a0\u6240\u81f4\u3002<\/li>\n<li>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u4e3a\u4eba\u6c11\u5e011,956.8\u767e\u4e07\u5143\u3002<\/li>\n<\/ul>\n<p><b>\u975e\u56fd\u9645\u8d22\u52a1\u62a5\u544a\u51c6\u5219\u8ba1\u91cf:<\/b><\/p>\n<ul type=\"disc\">\n<li>\u671f\u5185\u7ecf\u8c03\u6574\u51c0\u4e8f\u635f<sup>[1]<\/sup>\u7531\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01303.1\u767e\u4e07\u5143\u589e\u52a0\u4eba\u6c11\u5e01220.6\u767e\u4e07\u5143\u81f3\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u4eba\u6c11\u5e01523.7\u767e\u4e07\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u7814\u53d1\u5f00\u652f\u4ee5\u53ca\u5206\u9500\u53ca\u9500\u552e\u5f00\u652f\u589e\u52a0\u6240\u81f4\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u4e91\u9876\u65b0\u8000<\/b><\/p>\n<p>\u4e91\u9876\u65b0\u8000\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u521b\u65b0\u836f\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u6ee1\u8db3\u4e9a\u6d32\u5e02\u573a\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u4e91\u9876\u65b0\u8000\u7684\u7ba1\u7406\u56e2\u961f\u5728\u4e2d\u56fd\u53ca\u5168\u7403\u9886\u5148\u5236\u836f\u4f01\u4e1a\u4ece\u4e8b\u8fc7\u9ad8\u8d28\u91cf\u4e34\u5e8a\u5f00\u53d1\u3001\u836f\u653f\u4e8b\u52a1\u3001\u5316\u5b66\u5236\u9020\u4e0e\u63a7\u5236\uff08CMC\uff09\u3001\u4e1a\u52a1\u53d1\u5c55\u548c\u8fd0\u8425\uff0c\u62e5\u6709\u6df1\u539a\u7684\u4e13\u957f\u548c\u4e30\u5bcc\u7684\u7ecf\u9a8c\u3002\u4e91\u9876\u65b0\u8000\u5df2\u6253\u9020\u591a\u6b3e\u6709\u6f5c\u529b\u6210\u4e3a\u5168\u7403\u540c\u7c7b\u9996\u521b\u6216\u8005\u540c\u7c7b\u9886\u5148\u7684\u836f\u7269\u7ec4\u5408\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u540e\u671f\u9636\u6bb5\u3002\u516c\u53f8\u7684\u6cbb\u7597\u9886\u57df\u5305\u62ec\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u5fc3\u80be\u75be\u75c5\u3001\u611f\u67d3\u6027\u548c\u4f20\u67d3\u6027\u75be\u75c5\u3002\u6709\u5173\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9:<a 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NEFECON\uff08TarpeyoTM\uff09\u662f\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027\u514d\u75ab\u7403\u86cb\u767dA\u80be\u75c5\uff08IgAN\uff09\u7684\u65b0\u578b\u53e3\u670d\u9776\u5411\u5e03\u5730\u5948\u5fb7\u8fdf\u91ca\u80f6\u56ca &#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55: 2022\u5e743\u6708\uff0c\u672c\u516c\u53f8\u4e0eCalliditas\u7b7e\u8ba2\u6388\u6743\u534f\u8bae\uff0c\u4ee5\u5728\u97e9\u56fd\u5f00\u53d1\u53ca\u5546\u4e1a\u5316NEFECON\u7528\u4e8e\u6cbb\u7597\u539f\u53d1\u6027IgAN\uff0c\u6269\u5927\u4e86\u73b0\u6709\u5728\u5927\u4e2d\u534e\u533a\u53ca\u65b0\u52a0\u5761\u7684\u8bb8\u53ef\u6743\u3002\u8be5\u4ea4\u6613\u6807\u5fd7\u7740\u672c\u516c\u53f8\u4e3a\u8fdb\u4e00\u6b65\u6269\u5927\u5176\u56fd\u9645\u5546\u4e1a\u7248\u56fe\u800c\u4f5c\u51fa\u7684\u6700\u65b0\u52aa\u529b\u3002 2022\u5e744\u6708\uff0c\u672c\u516c\u53f8\u5ba3\u5e03\uff0c\u7ecfNEFECON\u6cbb\u7597\u4e5d\u4e2a\u6708\u540e\u4e2d\u56fd\u4e9a\u7ec4\u86cb\u767d\u5c3f\u4e0b\u964d\u53caeGFR\u7a33\u5b9a\u7684\u7ed3\u679c\u4e0eCalliditas Therapeutics AB\u4e8e2020\u5e7411\u6708\u516c\u5e03\u7684NefIgArd\u5173\u952e\u6027\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8cA\u90e8\u5206\u7684\u9876\u7ebf\u7ed3\u679c\u4e00\u81f4\u3002 &#8211; \u62a5\u544a\u671f\u540e\u6210\u5c31\u53ca\u9884\u671f\u91cc\u7a0b\u7891: 2022\u5e747\u6708\uff0c\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34Calliditas\u5c31Kinpeygo&reg;\uff08\u7814\u53d1\u540d\u79f0\u4e3aNEFECON\uff09\u5df2\u83b7\u6b27\u76df\u59d4\u5458\u4f1a\u9644\u6761\u4ef6\u4e0a\u5e02\u8bb8\u53ef\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u5177\u6709\u5feb\u901f\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\uff08\u5c3f\u86cb\u767d\u4e0e\u808c\u9150\u6bd4\uff08UPCR)\uff09\u2265 1.5\u514b\/\u514b\uff09\u7684\u539f\u53d1\u6027IgAN\u6210\u4eba\u60a3\u8005\u3002 \u6211\u4eec\u9884\u671f\u5c06\u4e8e2022\u5e74\u4e0b\u534a\u5e74\u5728\u4e2d\u56fd\u5c31NEFECON\u7528\u4e8e\u539f\u53d1\u6027IgAN\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002 Etrasimod\u662f\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08UC\uff09\u7684\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u9009\u62e9\u6027\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u53d7\u4f53\u8c03\u8282\u5242 &#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55: 2022\u5e745\u6708\uff0c\u6211\u4eec\u7684\u6388\u6743\u5408\u4f5c\u4f19\u4f34\u8f89\u745e\u516c\u53f8\u516c\u5e03\u4e86ELEVATE UC 3\u671f\u6ce8\u518c\u7814\u7a76\u4e0b\u4e24\u9879\u5173\u952e\u6027\u8bd5\u9a8c\u7684\u8be6\u7ec6\u7ed3\u679c\uff0c\u7814\u7a76\u8bc4\u4f30\u4e86\u9009\u62e9\u6027\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u53d7\u4f53\u8c03\u8282\u5242etrasimod\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6d3b\u52a8\u6027\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u6548\u679c\u3002\u8fd9\u4e24\u98793\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\u5747\u8fbe\u5230\u6240\u6709\u4e3b\u8981\u53ca\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u4e14etrasimod\u663e\u793a\u51fa\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u7684\u5b89\u5168\u6027\u3002\u5728\u4e3a\u671f52\u5468\u7684ELEVATE UC 52\u7814\u7a76\u4e2d\uff0c\u7b2c12\u5468\u65f6\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a27.0%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a7.4%\uff08\u5dee\u5f02\u4e3a19.8%\uff0cP = &lt;.001\uff09\uff1b \u7b2c52\u5468\u65f6\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a32.1%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a6.7%\uff08\u5dee\u5f02\u4e3a25.4%\uff0cP = &lt;.001\uff09\u3002\u5728\u4e3a\u671f12\u5468\u7684ELEVATE UC 12\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7etrasimod\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7f13\u89e3\u7387\u4e3a24.8%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u5bf9\u7167\u7684\u60a3\u8005\u4e3a15.2%\uff08\u5dee\u5f02\u4e3a9.7%\uff0cP = .0264\uff09\u3002ELEVATE UC 52\u53caUC 12\u7814\u7a76\u5f97\u51fa\u7684\u6570\u636e\u5c06\u4f5c\u4e3a\u7528\u4e8e\u76d1\u7ba1\u7533\u8bf7\u7684\u6570\u636e\u57fa\u7840\uff0c\u8f89\u745e\u9884\u671f\u5c06\u4e8e\u4eca\u5e74\u7a0d\u540e\u542f\u52a8\u6709\u5173\u7a0b\u5e8f\u3002 &#8211; \u62a5\u544a\u671f\u540e\u6210\u5c31\u53ca\u9884\u671f\u91cc\u7a0b\u7891: \u6211\u4eec\u6b63\u5728\u5f00\u5c55etrasimod\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6UC\u76843\u671f\u7814\u7a76\uff0c\u9884\u671f\u5c06\u4e8e2023\u5e74\u5b8c\u6210\u60a3\u8005\u62db\u52df\u3002 PTX-COVID19\u4e3a\u4e00\u79cd\u7531\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u914d\u5236\u5e76\u5177\u6709\u8f83\u5f3a\u514d\u75ab\u539f\u6027\u53ca\u8010\u53d7\u6027\u7684\u6f5c\u5728\u540c\u7c7b\u9886\u5148mRNA COVID-19\u75ab\u82d7 &#8211; \u62a5\u544a\u671f\u5185\u7684\u4ea7\u54c1\u8fdb\u5c55: 2022\u5e744\u6708\uff0c\u672c\u516c\u53f8\u5c31\u8bbe\u7acb\u5408\u4f19\u4f01\u4e1a\u4e0e\u534e\u6da6\u533b\u836f\u96c6\u56e2\u6709\u9650\u516c\u53f8\u7b7e\u8ba2\u5408\u4f5c\u5907\u5fd8\u5f55\uff0c\u62df\u6210\u7acb\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u53d1\u73b0\u3001\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178\uff08mRNA\uff09\u75ab\u82d7\u7684\u72ec\u7acb\u516c\u53f8\u3002\u4e0e\u534e\u6da6\u533b\u836f\u8ba1\u5212\u4e2d\u7684\u5408\u4f5c\uff0c\u5c06\u4e3amRNA\u516c\u53f8\u8fdb\u4e00\u6b65\u53d1\u5c55\u53d6\u5f97\u4f18\u52bf\uff0c\u901a\u8fc7\u5728\u6ce8\u518c\u3001\u5546\u4e1a\u5316\u7b49\u9886\u57df\u7684\u5408\u4f5c\uff0c\u6709\u529b\u63a8\u8fdb\u6211\u4eec\u6709\u540c\u7c7b\u9886\u5148\u6f5c\u529b\u7684mRNA\u5019\u9009\u75ab\u82d7\u5728\u4e2d\u56fd\u7684\u5f00\u53d1\u8fdb\u5ea6\u3002\u6839\u636e\u5408\u4f5c\u5907\u5fd8\u5f55\u7684\u6761\u6b3e\uff0cmRNA\u516c\u53f8\u5c06\u6210\u4e3a\u4e00\u5bb6\u72ec\u7acb\u8fd0\u8425\u7684\u516c\u53f8\uff0c\u63a5\u7ba1\u672c\u516c\u53f8\u4e0eProvidence 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