{"id":77103,"date":"2022-08-23T23:30:00","date_gmt":"2022-08-23T16:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082323300077103"},"modified":"2022-08-24T22:11:55","modified_gmt":"2022-08-24T14:11:55","slug":"%e5%8a%a0%e7%a7%91%e6%80%9d%e5%8f%91%e5%b8%832022%e4%b8%ad%e6%9c%9f%e4%b8%9a%e7%bb%a9%e5%85%ac%e5%91%8a-%e5%b8%83%e5%b1%80p53%e3%80%81parp7%e3%80%81iadc%e7%ad%89%e6%96%b0%e9%a1%b9%e7%9b%ae","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082323300077103","title":{"rendered":"\u52a0\u79d1\u601d\u53d1\u5e032022\u4e2d\u671f\u4e1a\u7ee9\u516c\u544a \u5e03\u5c40P53\u3001PARP7\u3001iADC\u7b49\u65b0\u9879\u76ee"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" title=\"logo\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/Logo-396.jpg\" alt=\"\" width=\"118\" border=\"0\" hspace=\"0\" vspace=\"0\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"prntac\" style=\"text-align: center\">\u7814\u53d1\u6295\u5165\u589e\u957f26.3%\u81f32.21\u4ebf\u5143\uff0c\u786e\u8ba4\u8425\u65365470\u4e07\u5143<\/p>\n<p class=\"prntac\" style=\"text-align: center\">\u52a0\u901fSHP2\u3001KRAS G12C<span id=\"spanHghltcbfb\">\u6291\u5236\u5242<\/span>\u7b49\u4e34\u5e8a\u9636\u6bb5\u9879\u76ee\u7684\u5168\u7403\u7814\u53d1<\/p>\n<p class=\"prntac\" style=\"text-align: center\">\u5e03\u5c40iADC\uff08\u514d\u75ab\u523a\u6fc0\u5242ADC\uff09\u3001P53\u3001PARP7\u7b49\u4e34\u5e8a\u524d\u9879\u76ee<\/p>\n<p><p><span class=\"legendSpanClass\">\u5317\u4eac\u3001\u4e0a\u6d77\u548c\u6ce2\u58eb\u987f<\/span><span class=\"legendSpanClass\">2022\u5e748\u670824\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u52a0\u79d1\u601d\u836f\u4e1a\uff081167.HK\uff09\u516c\u5e032022\u5e74\u4e2d\u671f\u4e1a\u7ee9\u62a5\u544a\u3002\u5728\u4e1a\u7ee9\u671f\u5185\uff0c\u7814\u53d1\u6295\u5165\u540c\u6bd4\u589e\u957f26.3%\u81f32.21\u4ebf\u5143\u3002\u5f97\u76ca\u4e8e\u6d77\u5916\u6388\u6743\u4ea4\u6613\u6240\u5e26\u6765\u7684\u6536\u5165\uff0c\u5f53\u671f\u786e\u8ba4\u8425\u65365470\u4e07\u5143\uff0c\u4e0e\u53bb\u5e74\u540c\u671f\u6301\u5e73\u3002\u52a0\u79d1\u601d\u540c\u65f6\u516c\u5e03\u4e86\u8fd1\u671f\u4e1a\u52a1\u8fdb\u5c55\u53ca\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\u3002<\/p>\n<p>\u52a0\u79d1\u601d\u8463\u4e8b\u957f\u517cCEO\u738b\u5370\u7965\u535a\u58eb\u6307\u51fa\uff0c&#8221;\u6211\u4eec\u57282022\u4e0a\u534a\u5e74\u52a0\u901f\u63a8\u8fdb\u4e34\u5e8a\u9879\u76ee\uff0cSHP2\u6291\u5236\u5242\u5728\u4e2d\u7f8e\u4e24\u56fd\u5b8c\u6210\u591a\u9879\u8054\u5408\u7597\u6cd5\u7684\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\uff0cKRAS G12C\u6291\u5236\u5242JAB-21822\u5728ASCO\u5e74\u4f1a\u516c\u5e03\u4e86\u4e34\u5e8a\u6570\u636e\uff0c\u5e76\u5c06\u4e34\u5e8a\u8bd5\u9a8c\u5730\u70b9\u9996\u6b21\u4ece\u4e2d\u7f8e\u6269\u5927\u81f3\u6b27\u6d32\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6211\u4eec\u5728\u4e34\u5e8a\u524d\u5e03\u5c40\u4e86\u591a\u4e2a\u65b0\u9776\u70b9\u9879\u76ee\uff0c\u5305\u62ecP53\u6291\u5236\u5242\u3001PARP7\u6291\u5236\u5242\u3001\u4ee5\u514d\u75ab\u523a\u6fc0\u5242\u4e3a\u8f7d\u8377\u7684iADC\u9879\u76ee\u7b49\uff0c\u4ee5\u6b64\u6269\u5145\u7ba1\u7ebf\uff0c\u8fdb\u4e00\u6b65\u5151\u73b0&#8217;\u4ee5\u5168\u7403\u5e02\u573a\u4e3a\u76ee\u6807\uff0c\u6838\u5fc3\u9879\u76ee\u5168\u7403\u524d\u4e09&#8217;\u7684\u6218\u7565\u76ee\u6807\u3002&#8221;<\/p>\n<p>\u6838\u5fc3\u4e34\u5e8a\u9879\u76ee\u8fdb\u5c55\uff1a<\/p>\n<p><strong><span class=\"xn-money\">SHP2<\/span><\/strong>\u6291\u5236\u5242<strong> JAB-3312 &amp; JAB-3068<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u4e0eKRAS G12C\u6291\u5236\u5242\u8054\u5408\u7528\u836f<\/li>\n<ul type=\"disc\">\n<li>\u5168\u7403\uff1aJAB-3312\u4e0eSotorasib\u8054\u5408\u7528\u836f\uff0c\u7528\u4e8e\u672a\u7ecfKRAS G12\u6cbb\u7597\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\u4e8e2022\u5e747\u6708\u5b8c\u6210<\/li>\n<li>\u4e2d\u56fd\uff1a\u4e0e\u81ea\u4e3b\u7814\u53d1\u7684JAB-21822\u8054\u5408\u7528\u836f\u8bd5\u9a8c\u4e8e5\u6708\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\uff0c\u4e34\u5e8a\u4e00\u671f\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u3002\u5728\u7b2c\u4e00\u4e2a\u5242\u91cf\u7ec4\u4e2d\u5df2\u6709\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u75c5\u4f8b\u3002<\/li>\n<\/ul>\n<li>\u4e0eEGFR\u6291\u5236\u5242\u8054\u5408\u7528\u836f<\/li>\n<ul type=\"disc\">\n<li>JAB-3312\u4e0eEGFR\u6291\u5236\u5242\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5728\u4e00\u4f8bEGFR\u8010\u836f\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u3002<\/li>\n<\/ul>\n<li>\u4e0ePD-1\u5355\u6297\u8054\u5408\u7528\u836f<\/li>\n<ul type=\"disc\">\n<li>JAB-3312\u4e0ePD-1\u8054\u5408\u7528\u836f\u7684\u5242\u91cf\u63a2\u7d22\u8bd5\u9a8c\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u8fdb\u884c\uff0c\u5728\u7279\u5b9a\u80bf\u7624\u60a3\u8005\u8eab\u4e0a\u89c2\u5bdf\u5230\u4e86\u65e9\u671f\u4e34\u5e8a\u6548\u679c\u3002<\/li>\n<\/ul>\n<li>\u5355\u836f\u4e34\u5e8a\u8bd5\u9a8c<\/li>\n<ul type=\"disc\">\n<li>JAB-3312\u4e0eJAB-3068\u7684\u5355\u836f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u786e\u5b9a\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08MTD\uff09\u548c\u63a8\u8350\u4e8c\u671f\u5242\u91cf(RP2D)<\/li>\n<\/ul>\n<\/ul>\n<p><strong>KRAS G12C<\/strong>\u6291\u5236\u5242<strong> JAB-21822<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u5355\u836f\u4e34\u5e8a\u8bd5\u9a8c<\/li>\n<ul type=\"disc\">\n<li>\u4e8e2022\u5e746\u6708\u5728ASCO\u5e74\u4f1a\u516c\u5e03\u4e2d\u56fd\u5355\u836f\u4e00\u671f\u4e34\u5e8a\u521d\u6b65\u6570\u636e\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a56.3%(18\/32)\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a90.6%\uff0829\/32\uff09\u3002\u4e00\u9879\u9488\u5bf9\u643a\u5e26KRAS G12C\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u5173\u952e\u6027\u8bd5\u9a8c\u9884\u8ba1\u5c06\u4e8e2022\u5e74\u4e0b\u534a\u5e74\u5c55\u5f00\u3002<\/li>\n<li>\u4e2d\u56fd\uff1a<span id=\"spanHghlt16f3\">\u6cbb\u7597<\/span>STK-11\u5171\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u5242\u91cf\u722c\u5761\u8bd5\u9a8c<span id=\"spanHghltf4d2\">\u9884\u8ba1<\/span>\u5c06\u4e8e2022\u5e749\u6708\u5728\u4e2d\u56fd\u5165\u7ec4<span id=\"spanHghlt9217\">\u9996\u4f8b\u60a3\u8005<\/span>\u3002<\/li>\n<li>\u5168\u7403\uff1a\u7ee7\u5f00\u542f\u7f8e\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u540e\uff0c5\u6708\u5728\u6b27\u6d32\u5165\u7ec4\u9996\u4f8b\u60a3\u8005\uff0c\u76ee\u524d\u5df2\u5165\u7ec4\u80f0\u817a\u5bfc\u7ba1\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u4e0b\u534a\u5e74\u5c06\u542f\u52a8\u5242\u91cf\u6269\u5c55\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<li>\u4e0eEGFR\u5355\u6297\u8054\u5408\u7528\u836f\uff1a\u9488\u5bf9\u7ed3\u76f4\u80a0\u764c\u7684\u5242\u91cf\u6269\u5c55\u8bd5\u9a8c\u5df2\u4e8e7\u6708\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u3002<\/li>\n<li>\u4e0eJAB-3312\u8054\u5408\u7528\u836f\uff1a\u4e0e\u81ea\u4e3b\u7814\u53d1\u7684JAB-3312\u8054\u5408\u7528\u836f\u8bd5\u9a8c\u4e8e5\u6708\u5728\u4e2d\u56fd\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\uff0c\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u3002\u5728\u7b2c\u4e00\u4e2a\u5242\u91cf\u7ec4\u4e2d\u5df2\u6709\u786e\u8ba4\u6709\u6548\uff08PR\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u75c5\u4f8b\u3002<\/li>\n<\/ul>\n<p>\u5176\u4ed6\u4e34\u5e8a\u9879\u76ee\u8fdb\u5c55<\/p>\n<ul type=\"disc\">\n<li>BET\u6291\u5236\u5242 JAB-8263\u5df2\u5728\u4e2d\u7f8e\u4e24\u56fd\u542f\u52a8\u4e34\u5e8a\u4e34\u5e8a\u4e00\u671f\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\uff0c\u5c06\u4e8e2022\u5e74\u56db\u5b63\u5ea6\u786e\u5b9a\u4e8c\u671f\u63a8\u8350\u5242\u91cf\u3002<\/li>\n<li>Aurora A\u6291\u5236\u5242 JAB-2485\u4e8e1\u6708\u5728\u7f8e\u56fd\u6536\u5230I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u8ba1\u5212\u4e8e2022\u5e74\u56db\u5b63\u5ea6\u5728\u7f8e\u56fd\u5165\u7ec4\u9996\u4f8b\u60a3\u8005\uff0c\u5df2\u4e8e8\u6708\u5728\u4e2d\u56fd\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/li>\n<li>CD73\u6291\u5236\u5242 JAB-BX102\u5df2\u4e8e3\u6708\u5728\u4e2d\u56fd\u83b7\u6279\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u7684<span id=\"spanHghlt9256\">I\/IIa<\/span>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u8ba1\u5212\u4e8e2022\u5e74\u4e09\u5b63\u5ea6\u5165\u7ec4\u9996\u4f8b\u60a3\u8005\u3002\u4e8e2021\u5e7410\u6708\u5728\u7f8e\u56fd\u83b7\u6279\u4e34\u5e8a<span id=\"spanHghlte50b\">I\/IIa<\/span>\u671f\u8bd5\u9a8c\uff0c\u4e34\u5e8a\u4e00\u671f\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\u7ed3\u675f\u540e\uff0c\u5c06\u4f1a\u8fdb\u5165IIa\u671f\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<p>\u52a0\u79d1\u601d\u53d1\u6325\u72ec\u6709\u7684\u5c0f\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u4f18\u52bf\uff0c\u9996\u6b21\u5e03\u5c40\u4ee5\u514d\u75ab\u523a\u6fc0\u5242\uff08STING\uff09\u4e3a\u8f7d\u8377\uff08Payload\uff09\u7684iADC\u4ea7\u54c1\uff0c\u4ee5\u6ee1\u8db3\u4f20\u7edfADC\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u52a0\u79d1\u601d\u76ee\u524d\u5df2\u5e03\u5c40HER2-STING iADC\u9879\u76eeJAB-BX400\uff0c\u4ee5\u53caCD73-STING iADC\u9879\u76eeJAB-X1800\uff0c\u8fd9\u4e24\u4e2a\u9879\u76ee\u9884\u8ba1\u5c06\u4e8e2024\u5e74\u63d0\u4ea4\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u3002\u52a0\u79d1\u601d\u6301\u7eed\u56f4\u7ed5KRAS\u4fe1\u53f7\u901a\u8def\u8fdb\u884c\u5e03\u5c40\uff0c\u5728\u4e34\u5e8a\u524d\u9879\u76ee\u4e2d\u5e03\u5c40\u4e86\u53e3\u670dKRAS<sup>multi<\/sup> \u6291\u5236\u5242JAB-23400\uff0cKRAS G12D\u6291\u5236\u5242JAB-22000\uff0c\u4ee5\u53caRAS\u901a\u8def\u7684\u5927\u5206\u5b50\u9879\u76eeJAB-BX300\u3002\u540c\u65f6\u4e5f\u5e03\u5c40\u4e86P53 Y220C\u6291\u5236\u5242JAB-30300\uff0cPARP7\u6291\u5236\u5242JAB-26766\uff0c\u4ee5\u53ca\u80bf\u7624\u4ee3\u8c22\u901a\u8def\u4e0a\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242JAB-24144\u3002<\/p>\n<p>\u5728\u4e1a\u7ee9\u671f\u5185\uff0c\u52a0\u79d1\u601d\u5168\u7403\u4e13\u5229\u7533\u8bf7\u6570\u91cf\u8fbe\u5230228\u9879\uff0c\u5168\u7403\u5458\u5de5\u4eba\u6570\u589e\u957f\u81f3285\u4eba\u3002<\/p>\n<p>\u52a0\u79d1\u601d\u8d22\u52a1\u7a33\u5065\uff0c\u5f97\u76ca\u4e8eSHP2\u9879\u76ee\u7684\u5bf9\u5916\u6388\u6743\u4ea4\u6613\u5e26\u6765\u7684\u73b0\u91d1\u6536\u5165\uff0c\u5728\u7814\u53d1\u6295\u5165\u6301\u7eed\u9ad8\u901f\u589e\u957f\u7684\u540c\u65f6\uff0c\u4f9d\u7136\u4fdd\u6301\u5145\u8db3\u7684\u73b0\u91d1\u50a8\u5907\uff0c\u73b0\u91d1\u751f\u547d\u5468\u671f\u7ea624-30\u4e2a\u6708\u3002<\/p>\n<p>\u7535\u8bdd\u4f1a\u8bae\u76f8\u5173\u4fe1\u606f<br \/>\u52a0\u79d1\u601d\u5c06\u4e8e\u5317\u4eac\u65f6\u95f42022\u5e748\u670824\u65e515:00-16:00\u4e3e\u529e\u7535\u8bdd\u4f1a\u8bae\u3002\u5982\u679c\u53c2\u52a0\u7535\u8bdd\u4f1a\u8bae\uff0c\u9700\u63d0\u524d\u6ce8\u518c\u3002\u6ce8\u518c\u94fe\u63a5\uff1a<a href=\"https:\/\/us02web.zoom.us\/webinar\/register\/WN_XraOAzPAQTOua54_IPV-PA\" rel=\"nofollow noopener\" 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