{"id":76818,"date":"2022-08-22T07:30:00","date_gmt":"2022-08-22T00:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082207300076818"},"modified":"2022-08-22T22:29:14","modified_gmt":"2022-08-22T14:29:14","slug":"%e8%af%ba%e8%af%9a%e5%81%a5%e5%8d%8e%e5%8f%91%e5%b8%832022%e5%b9%b4%e4%b8%ad%e6%9c%9f%e4%b8%9a%e7%bb%a9%e6%8a%a5%e5%91%8a%ef%bc%9a%e7%a0%94%e5%8f%91%e7%ae%a1%e7%ba%bf%e8%bf%9b%e5%b1%95%e9%a1%ba","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022082207300076818","title":{"rendered":"\u8bfa\u8bda\u5065\u534e\u53d1\u5e032022\u5e74\u4e2d\u671f\u4e1a\u7ee9\u62a5\u544a\uff1a\u7814\u53d1\u7ba1\u7ebf\u8fdb\u5c55\u987a\u5229 \u5546\u4e1a\u5316\u4e0d\u65ad\u63d0\u901f"},"content":{"rendered":"<p><p><span class=\"legendSpanClass\">\u5317\u4eac<\/span><span class=\"legendSpanClass\">2022\u5e748\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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type=\"disc\">\n<li>\u516c\u53f8\u603b\u6536\u5165\u540c\u6bd4\u4e0a\u6da8142%\uff0c\u4ece2021\u5e74\u4e0a\u534a\u5e74\u76841.02\u4ebf\u5143<sup>[1]<\/sup>\u5927\u5e45\u4e0a\u6da8\u81f32022\u4e0a\u534a\u5e74\u76842.46\u4ebf\u5143\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e\u5965\u5e03\u66ff\u5c3c\u7eb3\u5165\u533b\u4fdd\u540e\u7684\u9500\u552e\u653e\u91cf\u540c\u6bd4\u4e0a\u6da8115%\uff0c\u4ece2021\u4e0a\u534a\u5e74\u76841.01\u4ebf\u5143\u731b\u589e\u81f32022\u5e74\u4e0a\u534a\u5e74\u76842.17\u4ebf\u5143\u3002<\/li>\n<li>\u7814\u53d1\u8d39\u7528\u4ece2021\u5e74\u4e0a\u534a\u5e74\u76841.85\u4ebf\u5143\u589e\u81f32022\u5e74\u4e0a\u534a\u5e74\u76842.74\u4ebf\u5143\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\u66f4\u591a\u521b\u65b0\u836f\u9879\u76ee\u8fdb\u5165\u4e34\u5e8a\u4ee5\u53ca\u5f00\u5c55\u66f4\u591a\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>\u4e0d\u8003\u8651\u6c47\u7387\u5f71\u54cd\uff0c\u516c\u53f8\u4e8f\u635f\u5728\u62a5\u544a\u671f\u5185\u75312021\u5e74\u4e0a\u534a\u5e74\u76842.33\u4ebf\u5143\u589e\u81f32022\u5e74\u4e0a\u534a\u5e74\u76842.86\u4ebf\u5143\u30022022\u5e74\u4e0a\u534a\u5e74\u672a\u5b9e\u73b0\u7684\u6c47\u5151\u635f\u59311.6\u4ebf\u5143<sup>[2]<\/sup>\u3002<\/li>\n<li>\u516c\u53f8\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269<sup>[3]<\/sup>\u4ece2021\u5e74\u5e74\u5e95\u768465.50\u4ebf\u5143\u5fae\u964d\u81f32022\u5e74\u4e0a\u534a\u5e74\u768465.19\u4ebf\u5143\u3002<\/li>\n<\/ul>\n<p>\u76ee\u524d\uff0c\u8bfa\u8bda\u5065\u534e\u5df2\u7ecf\u5efa\u7acb\u4e86\u5f3a\u5927\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5176\u4e2d\u5965\u5e03\u66ff\u5c3c\u548ctafasitamab\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\uff0c\u8fd8\u670911\u6b3e\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\uff0c5\u6b3e\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u524d\u9636\u6bb5\uff0c\u6b63\u5728\u4e2d\u56fd\u548c\u5168\u7403\u8fdb\u884c30\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p><strong>\u8840\u6db2\u7624<\/strong><\/p>\n<p><strong><span style=\"text-decoration: underline\">\u5965\u5e03\u66ff\u5c3c\uff08<\/span><\/strong><strong><span style=\"text-decoration: underline\">BTK<\/span><\/strong><strong><span style=\"text-decoration: underline\">\u6291\u5236\u5242\uff09<br \/><\/span><\/strong><strong>\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5f00\u5c55\u591a\u9879\u9488\u5bf9\u8840\u6db2\u7624\u7684\u6ce8\u518c\u53ca\u63a2\u7d22\u6027\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/p>\n<ul type=\"disc\">\n<li>\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff08sNDA\uff09\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u3002\u56fd\u5185\u5c1a\u65e0BTK\u6291\u5236\u5242\u83b7\u6279\u7528\u4e8e\u590d\u53d1\/\u96be\u6cbb\u6027MZL\u60a3\u8005\uff0c\u671f\u5f85\u5965\u5e03\u66ff\u5c3c\u586b\u8865\u8fd9\u4e00\u9886\u57df\u7684\u7a7a\u767d\u3002<\/li>\n<li>\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u83b7NMPA\u53d7\u7406\u3002<\/li>\n<li>\u5965\u5e03\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624 \uff08SLL\uff09 III 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MCD\u4e9a\u578b\u60a3\u8005\uff0c\u5965\u5e03\u66ff\u5c3c\u8054\u5408\u6cbb\u7597\u65b9\u6848\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u4ece\u4e00\u7ebf\u5230\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597DLBCL\uff0c\u516c\u53f8\u62e5\u6709\u5965\u5e03\u66ff\u5c3c\u3001tafasitamab\u3001ICP-B02 \u548c ICP-490 \u5728\u5185\u591a\u79cd\u836f\u7269\u7ec4\u5408\uff0c\u4e3a\u8fd9\u4e00\u4fb5\u88ad\u6027\u6dcb\u5df4\u7624\u63d0\u4f9b\u66f4\u591a\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5965\u5e03\u66ff\u5c3c\u8054\u5408\u6297PD-1\u5355\u6297\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u539f\u53d1\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6dcb\u5df4\u7624\uff08PCNSL\uff09\u7684\u2161\u671f\u7814\u7a76\u521d\u6b65\u7ed3\u679c\u5728\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\uff08EHA\uff09\u5e74\u4f1a\u4e0a\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u53d1\u5e03\u3002\u6240\u6709\u60a3\u8005\u7684\u7597\u6548\u5747\u53ef\u8bc4\u4f30\u3002ORR\u4e3a 61.5%\uff0c\u5176\u4e2d\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\/CRu\uff09\u4e3a38.5%\uff0c\u90e8\u5206\u7f13\u89e3\u7387\uff08PR\uff09\u4e3a23%\u3002\u8be5\u7814\u7a76\u65b9\u6848\u603b\u4f53\u5b89\u5168\uff0c\u8010\u53d7\u6027\u826f\u597d\u3002<\/li>\n<li>\u5965\u5e03\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597MCL\u7684III\u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u3002<\/li>\n<\/ul>\n<p><strong>ICP-B04 (Tafasitamab)<\/strong><\/p>\n<ul type=\"disc\">\n<li>Tafasitamab\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027DLBCL\u5728\u535a\u9ccc\u4e50\u57ce\u5f00\u51fa\u9996\u65b9\uff0c\u5e76\u5728\u745e\u91d1\u6d77\u5357\u533b\u9662\u4e3a\u4e00\u540d\u7b26\u5408\u6761\u4ef6\u7684DLBCL\u60a3\u8005\u5b8c\u6210\u56fd\u5185\u9996\u4f8b\u6ce8\u5c04\u4f7f\u7528\u3002<\/li>\n<li>\u542f\u52a8tafasitamab\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u5728\u4e2d\u56fd\u7684II\u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>Tafasitamab\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027DLBCL\u83b7\u4e2d\u56fd\u300a2022\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u6dcb\u5df4\u7624\u8bca\u7597\u6307\u5357\u300b II\u7ea7\u63a8\u8350\u3002<\/li>\n<li>Tafasitamab\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u5728\u9999\u6e2f\u63d0\u4ea4\uff0c\u5e76\u5c06\u5728\u6fb3\u95e8\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u4e00\u65e6\u5728\u9999\u6e2f\u6216\u8005\u6fb3\u95e8\u83b7\u6279\uff0c\u8fd9\u6b3e\u521b\u65b0\u836f\u5c31\u53ef\u60e0\u53ca\u5927\u6e7e\u533a\u60a3\u8005\u3002<\/li>\n<li>\u8bfa\u8bda\u5065\u534e\u4e0eIncyte\u7684\u6218\u7565\u5408\u4f5c\u5c06\u4e3a\u63a2\u7d22tafasitamab\u548c\u5965\u5e03\u66ff\u5c3c\u4ee5\u53ca\u8bfa\u8bda\u5065\u534e\u5176\u4ed6\u7ba1\u7ebf\u8054\u5408\u6cbb\u7597B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u63d0\u4f9b\u4e86\u826f\u597d\u673a\u4f1a\uff0c\u4e5f\u5c06\u589e\u5f3a\u8bfa\u8bda\u5065\u534e\u5728\u8840\u6db2\u7624\u548c\u5b9e\u4f53\u7624\u9886\u57df\u7684\u5b9e\u529b\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-B02 (CM355)<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u8bfa\u8bda\u5065\u534e\u548c\u5eb7\u8bfa\u4e9a\u5408\u4f5c\u5f00\u53d1CD20xCD3\u53cc\u7279\u5f02\u6027\u6297\u4f53CM355\u5728\u4e2d\u56fd\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002\u76ee\u524d\uff0cCM355\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u6cbb\u7597CD20+B\u7ec6\u80de\u8840\u6db2\u7624\u7684\u4e34\u5e8a\u7814\u7a76\u3002CM355\u7279\u5f02\u6027\u7ed3\u5408CD20\u9633\u6027\u9776\u7ec6\u80de\u548cCD3\u9633\u6027T\u7ec6\u80de\uff0c\u5c06\u514d\u75abT\u7ec6\u80de\u62db\u52df\u81f3\u9776\u7ec6\u80de\u5468\u56f4\uff0c\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u8bf1\u5bfcT\u7ec6\u80de\u4ecb\u5bfc\u7684\u80bf\u7624\u7ec6\u80de\u6740\u4f24\uff08TDCC\uff09\u4f5c\u7528\u6740\u4f24\u9776\u7ec6\u80de\uff0c\u7528\u4e8e\u6cbb\u7597CD20+B\u7ec6\u80de\u8840\u6db2\u7624\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-490<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242ICP-490\u65b0\u836f\u7814\u7a76\uff08IND\uff09\u7533\u8bf7\u83b7NMPA\u53d7\u7406\u3002ICP-490\u662f\u8bfa\u8bda\u5065\u534e\u81ea\u4e3b\u7814\u53d1\u7684\u521b\u65b0\u836f\uff0c\u6e90\u81ea\u516c\u53f8\u7684\u5206\u5b50\u80f6\u5e73\u53f0\u3002ICP-490\u5c06\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\uff0c\u4ee5\u53ca\u5305\u62ec\u5f25\u6f2b\u5927 B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u5728\u5185\u7684\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u7b49\u8840\u6db2\u80bf\u7624\u75be\u75c5\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-248<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684BCL2\u6291\u5236\u5242IND\u7533\u8bf7\u83b7NMPA\u53d7\u7406\u3002ICP-248\u5c06\u5f00\u53d1\u7528\u4e8e\u5355\u836f\u6216\u4e0eBTK\u6291\u5236\u5242\u7b49\u5176\u4ed6\u836f\u7269\u8054\u5408\u6cbb\u7597\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u3001\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5 \uff08ALL\uff09\u7b49\u6076\u6027\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u3002<\/li>\n<\/ul>\n<p><strong>\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5<\/strong><\/p>\n<p><strong><span style=\"text-decoration: underline\">\u5965\u5e03\u66ff\u5c3c<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u6548\u679c<\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; \u5728\u6240\u6709\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u53e3\u670d\u5965\u5e03\u66ff\u5c3c50\u6beb\u514b\u300180\u6beb\u514b\u548c100\u6beb\u514b\u6cbb\u7597\u7684\u60a3\u8005\u5728\u7b2c12\u5468SLE\u53cd\u5e94\u6307\u6570-4\uff08SRI-4\uff09\u7684\u5e94\u7b54\u7387\u5206\u522b\u4e3a50.0%\uff087\/14\uff09\u300161.5%\uff088\/13\uff09\u548c64.3%\uff089\/14\uff09\uff0c\u800c\u670d\u7528\u5b89\u6170\u5242\u7684\u60a3\u8005SRI-4\u5e94\u7b54\u7387\u4e3a35.7%\uff085\/14\uff09\uff0c\u8fd9\u8868\u660e\u7597\u6548\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u6539\u5584\u8d8b\u52bf\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u89c2\u5bdf\u5230\u5c3f\u86cb\u767d\u6c34\u5e73\u964d\u4f4e\uff0c\u4ee5\u53ca\u514d\u75ab\u6807\u5fd7\u7269\u7684\u6539\u5584\u3002<\/p>\n<p class=\"prnml40\">&#8211; \u5965\u5e03\u66ff\u5c3c\u6cbb\u7597SLE\u7684\u4e0b\u4e00\u6b65\u4e34\u5e8a\u7814\u7a76\u8bbe\u8ba1\u5904\u4e8e\u6700\u540e\u7684\u8ba8\u8bba\u9636\u6bb5\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\uff08MS\uff09\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4e2d\u56fd\u5f00\u5c55\uff0c\u60a3\u8005\u5165\u7ec4\u8fdb\u5c55\u81f3\u6700\u540e\u62db\u52df\u9636\u6bb5\u3002<\/li>\n<li>\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u539f\u53d1\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08 ITP\uff09II\u671f\u4e34\u5e8a\u7814\u7a76\u5728\u4e2d\u56fd\u5373\u5c06\u5b8c\u6210\u60a3\u8005\u62db\u52df\u3002<\/li>\n<li>\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\uff08NMOSD\uff09II\u671f\u4e34\u5e8a\u7814\u7a76\u5728\u4e2d\u56fd\u542f\u52a8\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-332<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u65b0\u578b\u916a\u6c28\u9178\u6fc0\u91762\uff08TYK2\uff09\u6291\u5236\u5242I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\uff0cI\u671f\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002ICP-332\u6cbb\u7597\u7279\u5e94\u6027\u76ae\u708e\u548c\u94f6\u5c51\u75c5\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u542f\u52a8\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-488<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>ICP-488\u7684I\u671f\u4e34\u5e8a\u5df2\u5b8c\u6210\u7b2c\u4e00\u4e2a\u5242\u91cf\u7ec4\u8bd5\u9a8c\u3002ICP-488\u5c5e\u4e8e\u9009\u62e9\u6027TYK2\uff08\u916a\u6c28\u9178\u6fc0\u91762\uff09\u53d8\u6784\u6291\u5236\u5242\uff0c\u4f5c\u7528\u4e8e\u53d1\u6325\u8c03\u8282\u4f5c\u7528\u7684TYK2 JH2\uff0c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u94f6\u5c51\u75c5\u3001SLE\u548c\u708e\u75c7\u6027\u80a0\u75c5 (IBD) \u7b49\u708e\u75c7\u6027\u75be\u75c5\u3002<\/li>\n<\/ul>\n<p><strong>\u5b9e\u4f53\u7624<\/strong><\/p>\n<p><strong><span style=\"text-decoration: underline\">ICP-192 (Gunagratinib)<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u5b8c\u62102\u6beb\u514b\u523026\u6beb\u514b\u7684\u5242\u91cf\u9012\u589e\u7814\u7a76\uff0c\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u3002<\/li>\n<li>20\u6beb\u514b\u5242\u91cf\u7684gunagratinib\u5bf9\u80c6\u7ba1\u764c\u60a3\u8005\u663e\u793a\u8f83\u597d\u7597\u6548\u3002\u6839\u636eASCO\u516c\u5e03\u7684\u6570\u636e\uff0c\u5728\u81f3\u5c11\u5b8c\u6210\u4e00\u9879\u80bf\u7624\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a62.5%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a100%\u3002<\/li>\n<li>\u660e\u786e\u5b9a\u4f4d\u5c06gunagratinib\u6cbb\u7597\u80c6\u7ba1\u764c\u63a8\u5165\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>\u6b63\u5728\u4e2d\u56fd\u63a8\u8fdbgunagratinib\u6cbb\u7597\u5c3f\u8def\u4e0a\u76ae\u764cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>\u6b63\u5728\u4e2d\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u7f8e\u56fd\u63a8\u8fdb\u5305\u62ec\u80c3\u764c\u548c\u5934\u9888\u764c\u5728\u5185\u7684\u7bee\u5b50\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-723<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>ICP-723\u662f\u7b2c\u4e8c\u4ee3TRK\u6291\u5236\u5242\uff0c\u514b\u670d\u7b2c\u4e00\u4ee3TRK\u6291\u5236\u5242\u7684\u8010\u836f\u6027\u3002<\/li>\n<li>\u5728 I \u671f\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u4e2d\uff0c\u5df2\u5b8c\u62101\u6beb\u514b\u81f316\u6beb\u514b\u51718\u4e2a\u5242\u91cf\u7ec4\u7684\u6cbb\u7597\uff0c\u5747\u672a\u89c2\u5bdf\u5230DLT\u3002<\/li>\n<li>\u57284\u6beb\u514b\u53ca\u4ee5\u4e0a\u5242\u91cf\u7ec4\uff0cNTRK\u57fa\u56e0\u878d\u5408\u9633\u6027\u7684\u5404\u7c7b\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cORR\u4e3a100%\u3002<\/li>\n<li>\u660e\u786e\u5b9a\u4f4d\u5373\u5c06\u5728\u4e2d\u56fd\u63a8\u5165\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<li>\u7814\u7a76\u4e2d\u5c06\u589e\u52a0\u9752\u5c11\u5e74\u548c\u513f\u7ae5\u60a3\u8005\u3002<\/li>\n<li>\u5728\u7f8e\u56fd\u542f\u52a8\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-189<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u86cb\u767d\u916a\u6c28\u9178\u78f7\u9178\u9176SHP2\uff08Src Homology 2 domain containing protein tyrosine phosphatase\uff09\u53d8\u6784\u6291\u5236\u5242ICP-189\u5728\u4e2d\u56fd\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002ICP-189\u53ef\u7528\u4f5c\u5355\u836f\u7597\u6cd5\u53ca\/\u6216\u548c\u5176\u4ed6\u6297\u80bf\u7624\u836f\u7684\u8054\u5408\u7597\u6cd5\uff0c\u65e8\u5728\u4e3a\u80ba\u764c\u3001\u5934\u9888\u764c\u53ca\u6d88\u5316\u9053\u80bf\u7624\u7b49\u5b9e\u4f53\u7624\u63d0\u4f9b\u65b0\u7684\u4e34\u5e8a\u6cbb\u7597\u65b9\u6cd5\u3002ICP-189\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u90fd\u5df2\u83b7\u6279\u4e34\u5e8a\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-033<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u591a\u9776\u70b9\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff08RTK\uff09\u6291\u5236\u5242ICP-033\u5728\u4e2d\u56fd\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002ICP-033\u662f\u4e00\u79cd\u591a\u6fc0\u9176\u6291\u5236\u5242\uff0c\u4e3b\u8981\u9488\u5bf9\u76d8\u72b6\u7ed3\u6784\u57df\u53d7\u4f531\uff08DDR1\uff09\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08VEGFR\uff09\u6291\u5236\u80bf\u7624\u8840\u7ba1\u751f\u6210\uff0c\u8fd8\u53ef\u4ee5\u89e3\u9664\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\uff0c\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3001\u4fb5\u88ad\u548c\u8f6c\u79fb\u3002ICP-033\u8ba1\u5212\u5355\u7528\u6216\/\u548c\u514d\u75ab\u7597\u6cd5\u53ca\u5176\u4ed6\u9776\u5411\u836f\u8054\u5408\u6cbb\u7597\u809d\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u5927\u80a0\u764c\u53ca\u5176\u4ed6\u5b9e\u4f53\u80bf\u7624\u3002<\/li>\n<\/ul>\n<p><strong><span style=\"text-decoration: underline\">ICP-B05<\/span><\/strong><strong><span style=\"text-decoration: underline\">\uff08<\/span><\/strong><strong><span style=\"text-decoration: underline\">CM369<\/span><\/strong><strong><span style=\"text-decoration: underline\">\uff09<\/span><\/strong><\/p>\n<ul type=\"disc\">\n<li>\u8bfa\u8bda\u5065\u534e\u548c\u5eb7\u8bfa\u4e9a\u5408\u4f5c\u5f00\u53d1\u7684\u9776\u5411CCR8\u5355\u514b\u9686\u6297\u4f53CM369 IND\u7533\u8bf7\u83b7NMPA\u53d7\u7406\u3002CM369\u662f\u4e00\u79cd\u6297\u8d8b\u5316\u56e0\u5b50\u53d7\u4f538\uff08CCR8\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u662f\u53cc\u65b9\u516c\u53f8\u5171\u540c\u5f00\u53d1\u7684\u6f5c\u5728first-in-class\u836f\u7269\uff0c\u5c06\u5f00\u53d1\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u6216\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u6cbb\u7597\u9ad8\u53d1\u7684\u665a\u671f\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u80ba\u764c\u3001\u6d88\u5316\u9053\u764c\u7b49\u3002<\/li>\n<\/ul>\n<p><strong>\u516c\u53f8\u5176\u4ed6\u8fdb\u5c55<\/strong><\/p>\n<ul type=\"disc\">\n<li><strong>\u878d\u8d44<br \/><\/strong>\u4e2d\u56fd\u8bc1\u76d1\u4f1a\u53d1\u5e03\u516c\u544a\uff0c\u540c\u610f\u8bfa\u8bda\u5065\u534e\u533b\u836f\u6709\u9650\u516c\u53f8\u5728\u79d1\u521b\u677f\u9996\u6b21\u516c\u5f00\u53d1\u884c\u80a1\u7968\u6ce8\u518c\u3002<\/li>\n<li><strong>\u751f\u4ea7\u5efa\u8bbe<br \/><\/strong><strong>\u5e7f\u5dde\uff1a<\/strong>\u8bfa\u8bda\u5065\u534e\u5e7f\u5dde\u836f\u54c1\u751f\u4ea7\u57fa\u5730\u5546\u4e1a\u5316\u751f\u4ea7\u5df2\u6b63\u5f0f\u83b7\u6279\uff0c\u4ece6\u670830\u65e5\u8d77\u53ef\u7528\u4e8e\u751f\u4ea7\u5965\u5e03\u66ff\u5c3c\u7247\u3002\u8fd9\u6807\u5fd7\u7740\u8bfa\u8bda\u5065\u534e\u6b63\u5f0f\u5f00\u542f\u4e86\u81ea\u4e3b\u751f\u4ea7\u4e4b\u8def\uff0c\u5c06\u4e3a\u60a3\u8005\u63d0\u4f9b\u9ad8\u54c1\u8d28\u7684\u4ea7\u54c1\u548c\u670d\u52a1\u3002<br \/><strong>\u5317\u4eac\uff1a<\/strong>\u8bfa\u8bda\u5065\u534e\u521b\u65b0\u836f\u57fa\u5730\u5df2\u987a\u5229\u4e3e\u529e\u5f00\u5de5\u5960\u57fa\u4eea\u5f0f\uff0c\u5c06\u7528\u4e8e\u5efa\u8bbe\u516c\u53f8\u603b\u90e8\u5927\u697c\u3001\u521b\u65b0\u836f\u7814\u53d1\u4e2d\u5fc3\u548c\u5927\u5206\u5b50\u751f\u4ea7\u57fa\u5730\uff0c\u4ee5\u652f\u6301\u516c\u53f8\u4e0d\u65ad\u589e\u957f\u7684\u4e1a\u52a1\u9700\u6c42\u3002<\/li>\n<li><strong>\u6743\u5a01\u8bc1\u4e66<br \/><\/strong>\u51ed\u501f\u5728\u751f\u7269\u533b\u836f\u9886\u57df\u7684\u81ea\u4e3b\u521b\u65b0\u529b\u548c\u5e02\u573a\u7ade\u4e89\u529b\uff0c\u8bfa\u8bda\u5065\u534e\u8363\u83b7\u5317\u4eac\u5e02\u7ecf\u6d4e\u548c\u4fe1\u606f\u5316\u5c40\u4e13\u7cbe\u7279\u65b0&#8221;\u5c0f\u5de8\u4eba&#8221;\u4f01\u4e1a\u79f0\u53f7\u3002\u4f5c\u4e3a\u4e13\u7cbe\u7279\u65b0\u7684\u6392\u5934\u5175\uff0c\u4e13\u7cbe\u7279\u65b0&#8221;\u5c0f\u5de8\u4eba&#8221;\u4f01\u4e1a\u5df2\u6210\u4e3a\u63d0\u5347\u4ea7\u4e1a\u94fe\u3001\u4f9b\u5e94\u94fe\u7a33\u5b9a\u6027\u548c\u7ade\u4e89\u529b\u7684\u5173\u952e\u73af\u8282\uff0c\u6210\u4e3a\u57f9\u80b2\u5236\u9020\u4e1a\u5355\u9879\u51a0\u519b\u548c\u9886\u822a\u4f01\u4e1a\u7684\u540e\u5907\u519b\u3002<br \/>\u5965\u5e03\u66ff\u5c3c\u901a\u8fc7\u5317\u4eac\u5e02\u79d1\u5b66\u6280\u672f\u59d4\u5458\u4f1a\u3001\u4e2d\u5173\u6751\u79d1\u6280\u56ed\u533a\u7ba1\u7406\u59d4\u5458\u4f1a\u3001\u5317\u4eac\u5e02\u53d1\u5c55\u548c\u6539\u9769\u59d4\u5458\u4f1a\u3001\u5317\u4eac\u5e02\u7ecf\u6d4e\u548c\u4fe1\u606f\u5316\u5c40\u3001\u5317\u4eac\u5e02\u4f4f\u623f\u548c\u57ce\u4e61\u5efa\u8bbe\u59d4\u5458\u4f1a\u3001\u5317\u4eac\u5e02\u5e02\u573a\u76d1\u7763\u7ba1\u7406\u5c40\u4e94\u5927\u653f\u5e9c\u90e8\u95e8\u6743\u5a01\u8ba4\u5b9a\uff0c\u8363\u83b7 &#8220;\u5317\u4eac\u5e02\u65b0\u6280\u672f\u65b0\u4ea7\u54c1\uff08\u670d\u52a1\uff09\u8bc1\u4e66&#8221;\u3002<\/li>\n<\/ul>\n<p>&#8220;\u5c55\u671b2022\u5e74\u4e0b\u534a\u5e74\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301&lsquo;\u79d1\u5b66\u9a71\u52a8\u521b\u65b0&nbsp;\u60a3\u8005\u6240\u9700\u4e3a\u672c&#8217;\u7684\u4ef7\u503c\u7406\u5ff5\uff0c\u4e0d\u65ad\u52a0\u5f3a\u6211\u4eec\u7814\u53d1\u5e73\u53f0\u5efa\u8bbe\uff0c\u6301\u7eed\u63a8\u8fdb\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u540c\u65f6\u79ef\u6781\u63a2\u7d22\u56fd\u9645\u4e1a\u52a1\u62d3\u5c55\u673a\u4f1a\u8fdb\u4e00\u6b65\u91ca\u653e\u6211\u4eec\u7684\u521b\u65b0\u6f5c\u80fd\uff0c\u4e3a\u793e\u4f1a\u5404\u754c\u521b\u9020\u66f4\u5927\u4ef7\u503c\uff0c&#8221;\u5d14\u9701\u677e\u535a\u58eb\u8bf4\u3002<\/p>\n<p>\u60f3\u8981\u4e86\u89e3\u8bfa\u8bda\u5065\u534e2022\u5e74\u4e2d\u671f\u4e1a\u7ee9\u62a5\u544a\u8d22\u52a1\u6570\u636e\uff0c\u656c\u8bf7\u767b\u5f55<a href=\"https:\/\/cn.innocarepharma.com\/en\/investor-relations\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/cn.innocarepharma.com\/en\/investor-relations\/<\/a>&nbsp;&nbsp;&nbsp;\u8fdb\u884c\u67e5\u8be2\u3002<\/p>\n<p><strong>\u7f51\u7edc\u4f1a\u8bae\u4fe1\u606f<\/strong><\/p>\n<p>\u8bfa\u8bda\u5065\u534e\u5c06\u4e8e\u5317\u4eac\u65f6\u95f42022\u5e748\u670822\u65e5\u65e9\u4e0a9\u70b9\u53ec\u5f002022\u5e74\u4e2d\u671f\u4e1a\u7ee9\u7f51\u7edc\u4f1a\u8bae\u3002\u5982\u8981\u53c2\u52a0\u7535\u8bdd\u4f1a\u8bae\uff0c\u9700\u63d0\u524d\u6ce8\u518c\u3002\u8be6\u60c5\u5982\u4e0b\uff1a<\/p>\n<p>\u5927\u9646\u5730\u533a\u6295\u8d44\u8005\u8bf7\u70b9\u51fb\u5982\u4e0b\u94fe\u63a5\u6ce8\u518c\uff1a<br \/><a href=\"https:\/\/morganstanley.gmwebcasts.cn\/starthere.jsp?ei=1559134&amp;tp_key=510cd87f77\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/morganstanley.gmwebcasts.cn\/starthere.jsp?ei=1559134&amp;tp_key=510cd87f77<\/a><\/p>\n<p>\u975e\u5927\u9646\u5730\u533a\u6295\u8d44\u8005\u8bf7\u70b9\u51fb\u5982\u4e0b\u94fe\u63a5\u6ce8\u518c\uff1a<br \/><a href=\"https:\/\/morganstanley.webcasts.com\/starthere.jsp?ei=1559134&amp;tp_key=510cd87f77\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/morganstanley.webcasts.com\/starthere.jsp?ei=1559134&amp;tp_key=510cd87f77<\/a><\/p>\n<p>\u4f1a\u8bae\u8bed\u8a00\u4e3a\u4e2d\u6587\u3002<\/p>\n<p><strong>\u524d\u77bb\u6027\u58f0\u660e<\/strong><\/p>\n<p>\u672c\u62a5\u9053\u542b\u6709\u4e00\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u7684\u62ab\u9732\u3002\u9664\u5bf9\u4e8b\u5b9e\u7684\u9648\u8ff0\u4ee5\u5916\uff0c\u6240\u6709\u5176\u4ed6\u58f0\u660e\u53ef\u88ab\u770b\u4f5c\u662f\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5373\u5173\u4e8e\u6211\u4eec\u6216\u8005\u6211\u4eec\u7684\u7ba1\u7406\u90e8\u95e8\u6253\u7b97\u3001\u671f\u671b\u3001\u8ba1\u5212\u3001\u76f8\u4fe1\u6216\u8005\u9884\u671f\u5c06\u4f1a\u6216\u8005\u53ef\u80fd\u4f1a\u5728\u672a\u6765\u53d1\u751f\u7684\u884c\u4e3a\u3001\u4e8b\u4ef6\u6216\u8005\u53d1\u5c55\u6240\u505a\u51fa\u7684\u58f0\u660e\u3002\u6b64\u7c7b\u58f0\u660e\u662f\u6211\u4eec\u7684\u7ba1\u7406\u90e8\u95e8\u6839\u636e\u5176\u7ecf\u9a8c\u548c\u5bf9\u5386\u53f2\u8d8b\u52bf\u3001\u5f53\u524d\u6761\u4ef6\u3001\u9884\u671f\u672a\u6765\u53d1\u5c55\u548c\u5176\u4ed6\u76f8\u5173\u56e0\u7d20\u7684\u8ba4\u77e5\uff0c\u505a\u51fa\u7684\u5047\u8bbe\u4e0e\u4f30\u8ba1\u3002\u8be5\u524d\u77bb\u6027\u58f0\u660e\u5e76\u4e0d\u80fd\u4fdd\u8bc1\u672a\u6765\u7684\u4e1a\u7ee9\uff0c\u5b9e\u9645\u7684\u7ed3\u679c\uff0c\u53d1\u5c55\u548c\u4e1a\u52a1\u51b3\u7b56\u53ef\u80fd\u4e0e\u8be5\u524d\u77bb\u6027\u58f0\u660e\u7684\u8bbe\u60f3\u4e0d\u7b26\u3002\u6211\u4eec\u7684\u524d\u77bb\u6027\u58f0\u660e\u540c\u6837\u53d7\u5230\u5927\u91cf\u7684\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u56e0\u7d20\u7684\u5236\u7ea6\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5f71\u54cd\u6211\u4eec\u7684\u8fd1\u671f\u4ee5\u53ca\u957f\u671f\u7684\u4e1a\u7ee9\u8868\u73b0\u3002<\/p>\n<p><strong>\u5173\u4e8e\u8bfa\u8bda\u5065\u534e<\/strong><\/p>\n<p>\u8bfa\u8bda\u5065\u534e\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a09969\uff09\u662f\u4e00\u5bb6\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u751f\u7269\u533b\u836f\u9ad8\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u6076\u6027\u80bf\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6cbb\u7597\u9886\u57df\u7684\u4e00\u7c7b\u65b0\u836f\u7814\u5236\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u6dcb\u5df4\u7624\u3001\u5b9e\u4f53\u7624\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u73b0\u6709\u591a\u4e2a\u65b0\u836f\u4ea7\u54c1\u5904\u4e8e\u5546\u4e1a\u5316\u3001\u4e34\u5e8a\u53ca\u4e34\u5e8a\u524d\u7814\u53d1\u9636\u6bb5\u3002\u516c\u53f8\u5728\u5317\u4eac\u3001\u5357\u4eac\u3001\u4e0a\u6d77\u3001\u5e7f\u5dde\u3001\u9999\u6e2f\u548c\u7f8e\u56fd\u8bbe\u6709\u5206\u652f\u673a\u6784\u3002<\/p>\n<p><span id=\"spanHghlt2cc8\">\u76f8\u5173\u94fe\u63a5\uff1a<a href=\"https:\/\/cn.innocarepharma.com\/cn\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/cn.innocarepharma.com\/cn\/<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n[1]&nbsp;\u8d22\u52a1\u4e1a\u7ee9\u6458\u8981\u4e2d\u7684\u8d27\u5e01\u5747\u4e3a\u4eba\u6c11\u5e01<br \/>[2]&nbsp;\u7531\u4e8e\u6c47\u7387\u53d8\u52a8\u53d1\u751f\u7684\u6c47\u5151\u53d8\u52a8\uff0c\u4f46\u5c1a\u672a\u5b9e\u9645\u53d1\u751f\u786e\u8ba4\u7684\u635f\u5931\u3002&nbsp;<br \/>[3]&nbsp;\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269\u6307\u7684\u662f\u73b0\u91d1\u3001\u94f6\u884c\u5b58\u6b3e\u4f59\u989d\u548c\u7406\u8d22\u4ea7\u54c1<\/p>\n<div>\n<table class=\"prnbcc\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><strong>\u8054\u7cfb\u4eba<\/strong><\/span><\/p>\n<\/td>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><strong>\u5a92\u4f53<\/strong><\/span><\/p>\n<\/td>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><strong>\u6295\u8d44\u8005<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u9646\u6625\u534e<\/span><\/p>\n<\/td>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">86-10-66609879&nbsp;<\/span><\/p>\n<\/td>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">86-10-66609999<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><a class=\"prnews_a\" href=\"mailto:chunhua.lu@innocarepharma.com\" rel=\"nofollow noopener\" target=\"_blank\">chunhua.lu@innocarepharma.com<\/a>&nbsp;&nbsp;<\/span><\/p>\n<\/td>\n<td class=\"prngen2\" rowspan=\"1\" colspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><a class=\"prnews_a\" href=\"mailto:ir@innocarepharma.com\" rel=\"nofollow noopener\" target=\"_blank\">ir@innocarepharma.com<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac2022\u5e748\u670822\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u8bfa\u8bda\u5065\u534e\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a09969\uff09\u4eca\u65e5\u53d1\u5e03\u622a\u81f32022\u5e746\u670830\u65e5\u76842022\u5e74\u4e2d\u671f\u4e1a\u7ee9\u62a5\u544a\u548c\u516c\u53f8\u8fdb\u5c55\u3002 \u8bfa\u8bda\u5065\u534e\u8054\u5408\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u5d14\u9701\u677e\u535a\u58eb\u8bf4\uff1a&#8221;2022\u5e74\u4e2d\u671f\u62a5\u544a\u6070\u9022\u6211\u4eec\u8bfa\u8bda\u5065\u534e\u6210\u7acb\u4e03\u5468\u5e74\u3002\u5c3d\u7ba1\u5b8f\u89c2\u73af\u5883\u5145\u6ee1\u6311\u6218\uff0c\u6211\u4eec\u6392\u9664\u4e07\u96be\u7ee7\u7eed\u51dd\u5fc3\u805a\u529b\u8e14\u5389\u594b\u53d1\uff0c2022\u5e74\u4e0a\u534a\u5e74\u5728\u5404\u4e2a\u9886\u57df\u7ee7\u7eed\u53d6\u5f97\u7a81\u7834\uff1a\u5965\u5e03\u66ff\u5c3c2022\u5e74\u4e0a\u534a\u5e74\u5b9e\u73b0\u533b\u4fdd\u540e\u7684\u9500\u552e\u653e\u91cf\uff1btafasitamab\u9996\u65b9\u843d\u5730\u535a\u9ccc\u4e50\u57ce\uff0c\u5e76\u5728\u56fd\u5185\u542f\u52a8II\u671f\u6ce8\u518c\u7814\u7a76\uff1b\u6211\u4eec\u6301\u7eed\u52a0\u5927\u6e90\u5934\u521b\u65b0\u548c\u4e34\u5e8a\u5f00\u53d1\u529b\u5ea6\uff0c\u5df2\u670911\u6b3e\u836f\u7269\u63a8\u8fdb\u81f3\u4e34\u5e8a\uff0c\u5e0c\u671b\u8fd9\u4e9b\u521b\u65b0\u836f\u80fd\u591f\u65e9\u65e5\u6ee1\u8db3\u90a3\u4e9b\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff1b\u6211\u4eec\u4e0e\u6e24\u5065\u548cIncyte\u516c\u53f8\u7684\u56fd\u9645\u5408\u4f5c\u9879\u76ee\u7ee7\u7eed\u987a\u5229\u5f80\u524d\u63a8\u8fdb&hellip;&hellip;&#8221; \u4e3b\u8981\u8d22\u52a1\u4e1a\u7ee9\u6458\u8981 \u516c\u53f8\u603b\u6536\u5165\u540c\u6bd4\u4e0a\u6da8142%\uff0c\u4ece2021\u5e74\u4e0a\u534a\u5e74\u76841.02\u4ebf\u5143[1]\u5927\u5e45\u4e0a\u6da8\u81f32022\u4e0a\u534a\u5e74\u76842.46\u4ebf\u5143\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e\u5965\u5e03\u66ff\u5c3c\u7eb3\u5165\u533b\u4fdd\u540e\u7684\u9500\u552e\u653e\u91cf\u540c\u6bd4\u4e0a\u6da8115%\uff0c\u4ece2021\u4e0a\u534a\u5e74\u76841.01\u4ebf\u5143\u731b\u589e\u81f32022\u5e74\u4e0a\u534a\u5e74\u76842.17\u4ebf\u5143\u3002 \u7814\u53d1\u8d39\u7528\u4ece2021\u5e74\u4e0a\u534a\u5e74\u76841.85\u4ebf\u5143\u589e\u81f32022\u5e74\u4e0a\u534a\u5e74\u76842.74\u4ebf\u5143\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\u66f4\u591a\u521b\u65b0\u836f\u9879\u76ee\u8fdb\u5165\u4e34\u5e8a\u4ee5\u53ca\u5f00\u5c55\u66f4\u591a\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u4e0d\u8003\u8651\u6c47\u7387\u5f71\u54cd\uff0c\u516c\u53f8\u4e8f\u635f\u5728\u62a5\u544a\u671f\u5185\u75312021\u5e74\u4e0a\u534a\u5e74\u76842.33\u4ebf\u5143\u589e\u81f32022\u5e74\u4e0a\u534a\u5e74\u76842.86\u4ebf\u5143\u30022022\u5e74\u4e0a\u534a\u5e74\u672a\u5b9e\u73b0\u7684\u6c47\u5151\u635f\u59311.6\u4ebf\u5143[2]\u3002 \u516c\u53f8\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269[3]\u4ece2021\u5e74\u5e74\u5e95\u768465.50\u4ebf\u5143\u5fae\u964d\u81f32022\u5e74\u4e0a\u534a\u5e74\u768465.19\u4ebf\u5143\u3002 \u76ee\u524d\uff0c\u8bfa\u8bda\u5065\u534e\u5df2\u7ecf\u5efa\u7acb\u4e86\u5f3a\u5927\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5176\u4e2d\u5965\u5e03\u66ff\u5c3c\u548ctafasitamab\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\uff0c\u8fd8\u670911\u6b3e\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\uff0c5\u6b3e\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u524d\u9636\u6bb5\uff0c\u6b63\u5728\u4e2d\u56fd\u548c\u5168\u7403\u8fdb\u884c30\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u8840\u6db2\u7624 \u5965\u5e03\u66ff\u5c3c\uff08BTK\u6291\u5236\u5242\uff09\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5f00\u5c55\u591a\u9879\u9488\u5bf9\u8840\u6db2\u7624\u7684\u6ce8\u518c\u53ca\u63a2\u7d22\u6027\u4e34\u5e8a\u8bd5\u9a8c \u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\uff08sNDA\uff09\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u3002\u56fd\u5185\u5c1a\u65e0BTK\u6291\u5236\u5242\u83b7\u6279\u7528\u4e8e\u590d\u53d1\/\u96be\u6cbb\u6027MZL\u60a3\u8005\uff0c\u671f\u5f85\u5965\u5e03\u66ff\u5c3c\u586b\u8865\u8fd9\u4e00\u9886\u57df\u7684\u7a7a\u767d\u3002 \u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u83b7NMPA\u53d7\u7406\u3002 \u5965\u5e03\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624 \uff08SLL\uff09 III \u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u4e2d\u56fd\u8fdb\u884c\uff0c\u76ee\u524d\u60a3\u8005\u5165\u7ec4\u5df2\u8fc7\u534a\u3002 \u5728\u7f8e\u56fd\uff0c\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09 \u7684 II \u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u5c06\u4e8e 2022 \u5e74\u5b8c\u6210\u60a3\u8005\u5165\u7ec4\u3002 \u5728\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u9886\u57df\u6df1\u5ea6\u5e03\u5c40 &#8211; \u5965\u5e03\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597DLBCL MCD \u4e9a\u578b\u6ce8\u518c\u7814\u7a76\u5df2\u542f\u52a8\u3002 &#8211; 2022 \u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u516c\u5e03\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597DLBCL\u7684\u771f\u5b9e\u4e16\u754c\u7814\u7a76\uff0c\u5bf9\u4e8eDLBCL MCD\u4e9a\u578b\u60a3\u8005\uff0c\u5965\u5e03\u66ff\u5c3c\u8054\u5408\u6cbb\u7597\u65b9\u6848\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u3002 &#8211; \u4ece\u4e00\u7ebf\u5230\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597DLBCL\uff0c\u516c\u53f8\u62e5\u6709\u5965\u5e03\u66ff\u5c3c\u3001tafasitamab\u3001ICP-B02 \u548c ICP-490 \u5728\u5185\u591a\u79cd\u836f\u7269\u7ec4\u5408\uff0c\u4e3a\u8fd9\u4e00\u4fb5\u88ad\u6027\u6dcb\u5df4\u7624\u63d0\u4f9b\u66f4\u591a\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002 \u5965\u5e03\u66ff\u5c3c\u8054\u5408\u6297PD-1\u5355\u6297\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u539f\u53d1\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6dcb\u5df4\u7624\uff08PCNSL\uff09\u7684\u2161\u671f\u7814\u7a76\u521d\u6b65\u7ed3\u679c\u5728\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\uff08EHA\uff09\u5e74\u4f1a\u4e0a\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u53d1\u5e03\u3002\u6240\u6709\u60a3\u8005\u7684\u7597\u6548\u5747\u53ef\u8bc4\u4f30\u3002ORR\u4e3a 61.5%\uff0c\u5176\u4e2d\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\/CRu\uff09\u4e3a38.5%\uff0c\u90e8\u5206\u7f13\u89e3\u7387\uff08PR\uff09\u4e3a23%\u3002\u8be5\u7814\u7a76\u65b9\u6848\u603b\u4f53\u5b89\u5168\uff0c\u8010\u53d7\u6027\u826f\u597d\u3002 \u5965\u5e03\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597MCL\u7684III\u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u3002 ICP-B04 (Tafasitamab) Tafasitamab\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027DLBCL\u5728\u535a\u9ccc\u4e50\u57ce\u5f00\u51fa\u9996\u65b9\uff0c\u5e76\u5728\u745e\u91d1\u6d77\u5357\u533b\u9662\u4e3a\u4e00\u540d\u7b26\u5408\u6761\u4ef6\u7684DLBCL\u60a3\u8005\u5b8c\u6210\u56fd\u5185\u9996\u4f8b\u6ce8\u5c04\u4f7f\u7528\u3002 \u542f\u52a8tafasitamab\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u5728\u4e2d\u56fd\u7684II\u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u3002 Tafasitamab\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027DLBCL\u83b7\u4e2d\u56fd\u300a2022\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u6dcb\u5df4\u7624\u8bca\u7597\u6307\u5357\u300b II\u7ea7\u63a8\u8350\u3002 Tafasitamab\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u5728\u9999\u6e2f\u63d0\u4ea4\uff0c\u5e76\u5c06\u5728\u6fb3\u95e8\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u4e00\u65e6\u5728\u9999\u6e2f\u6216\u8005\u6fb3\u95e8\u83b7\u6279\uff0c\u8fd9\u6b3e\u521b\u65b0\u836f\u5c31\u53ef\u60e0\u53ca\u5927\u6e7e\u533a\u60a3\u8005\u3002 \u8bfa\u8bda\u5065\u534e\u4e0eIncyte\u7684\u6218\u7565\u5408\u4f5c\u5c06\u4e3a\u63a2\u7d22tafasitamab\u548c\u5965\u5e03\u66ff\u5c3c\u4ee5\u53ca\u8bfa\u8bda\u5065\u534e\u5176\u4ed6\u7ba1\u7ebf\u8054\u5408\u6cbb\u7597B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u63d0\u4f9b\u4e86\u826f\u597d\u673a\u4f1a\uff0c\u4e5f\u5c06\u589e\u5f3a\u8bfa\u8bda\u5065\u534e\u5728\u8840\u6db2\u7624\u548c\u5b9e\u4f53\u7624\u9886\u57df\u7684\u5b9e\u529b\u3002 ICP-B02 (CM355) 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