{"id":76359,"date":"2022-08-18T09:09:00","date_gmt":"2022-08-18T02:09:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022081809090076359"},"modified":"2022-08-18T22:11:35","modified_gmt":"2022-08-18T14:11:35","slug":"%e7%a7%91%e6%b5%8e%e8%8d%af%e4%b8%9act011%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9f%e8%82%9d%e7%bb%86%e8%83%9e%e7%99%8c%e7%9a%84%e9%95%bf%e6%9c%9f%e7%94%9f%e5%ad%98%e6%a1%88%e4%be%8b%e6%8a%a5%e5%91%8a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022081809090076359","title":{"rendered":"\u79d1\u6d4e\u836f\u4e1aCT011\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u957f\u671f\u751f\u5b58\u6848\u4f8b\u62a5\u544a\u5728\u300aFrontiers in Immunology\u300b\u6742\u5fd7\u53d1\u8868"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u6d77<\/span>, 2022\u5e748\u670818\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\uff0c\u4e00\u5bb6\u4e3b\u8981\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u9776\u5411<\/b>GPC3<\/b>\u7684<\/b>CAR-T<\/b>\u7ec6\u80de\u5019\u9009\u4ea7<\/b>\u54c1<\/b>CT011<\/b>\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u957f\u671f\u751f\u5b58\u6848\u4f8b\u62a5\u544a\u5df2\u5728\u300a<\/b>Frontiers in Immunology<\/b>\u300b<\/b>\u6742\u5fd7\u53d1\u8868<\/b>\uff0c\u9898\u4e3a"Long Term Complete Response of Advanced Hepatocellular Carcinoma to Glypican-3 Specific Chimeric Antigen Receptor T-Cells plus Sorafenib, A case report"\u3002\uff08https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.963031\/full<\/a> \uff09<\/p>\n

\u809d\u764c\u662f\u5168\u7403\u7b2c\u516d\u5927\u5e38\u89c1\u764c\u75c7\uff0c\u800c\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u662f\u539f\u53d1\u6027\u809d\u764c\u6700\u5e38\u89c1\u7684\u7ec4\u7ec7\u5b66\u4e9a\u578b\u3002\u73b0\u6709\u7597\u6cd5\u5bf9\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u7597\u6548\u4ecd\u8f83\u6709\u9650\u3002CAR-T\u7ec6\u80de\u7597\u6cd5\u5df2\u7ecf\u83b7\u6279\u7528\u4e8e\u591a\u79cd\u8840\u6db2\u80bf\u7624\uff0c\u4f46\u5176\u7528\u4e8e\u5b9e\u4f53\u7624\u4ecd\u9762\u5bf9\u6781\u5927\u6311\u6218\u3002\u6211\u4eec\u662f\u6700\u65e9\u62a5\u544aGPC3\u662fCAR-T\u5408\u7406\u6cbb\u7597\u9776\u70b9\u7684\u56e2\u961f\uff0c\u5e76\u7387\u5148\u5f00\u5c55\u4e86\u7528\u4e8e\u809d\u7ec6\u80de\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c[1,2]<\/span><\/sup> \u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u589e\u5f3a\u5176\u7597\u6548\uff0c\u6211\u4eec\u4e8e2014\u5e74\u62a5\u9053\u4e86\u91c7\u7528GPC3 CAR-T\u4e0e\u7d22\u62c9\u975e\u5c3c\u8054\u5408\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u7684\u4e34\u5e8a\u524d\u7814\u7a76[3]<\/span><\/sup>\u3002\u4e3a\u4e86\u5c1d\u8bd5\u8be5\u7b56\u7565\u662f\u5426\u80fd\u5728\u4e34\u5e8a\u4e2d\u5b9e\u73b0\uff0c\u6211\u4eec\u5728\u6e29\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u5f00\u5c55\u4e86\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8be5\u7814\u7a76\u62a5\u544a\u4e86\u4e00\u540d\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u5728\u63a5\u53d7<\/b>GPC3 CAR-T<\/b>\u7ec6\u80de\u4e0e\u7d22\u62c9\u975e\u5c3c\u8054\u5408\u6cbb\u7597\u540e\u83b7\u5f97\u4e86\u5b8c\u5168\u7f13\u89e3\uff08<\/b>CR<\/b>\uff09<\/b>\u548c\u957f\u671f\u751f\u5b58\u3002<\/b><\/p>\n

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\n

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\u53c2\u8003\u6587\u732e<\/b><\/p>\n

1.      Gao H, et. al. <\/b>Clin Cancer Res<\/span><\/i>. 2014 Dec 15;20(24):6418-28
2.      Shi D, et. al. Clin Cancer Res<\/span><\/i>. 2020 Aug 1<\/span>;26(15):3979-3989
3.      Wu X, et. al. Mol Ther.<\/i> 2019 Aug 7<\/span>;27(8):1483-1494<\/p>\n

\u8054\u7cfb\u6211\u4eec<\/b><\/p>\n

\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1ahttps:\/\/www.carsgen.com\/<\/a>  <\/p>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d77, 2022\u5e748\u670818\u65e5 \/\u7f8e\u901a\u793e\/ — \u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\uff0c\u4e00\u5bb6\u4e3b\u8981\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u9776\u5411GPC3\u7684CAR-T\u7ec6\u80de\u5019\u9009\u4ea7\u54c1CT011\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u7684\u957f\u671f\u751f\u5b58\u6848\u4f8b\u62a5\u544a\u5df2\u5728\u300aFrontiers in Immunology\u300b\u6742\u5fd7\u53d1\u8868\uff0c\u9898\u4e3a"Long Term Complete Response of Advanced Hepatocellular Carcinoma to Glypican-3 Specific Chimeric Antigen Receptor T-Cells plus Sorafenib, A case report"\u3002\uff08https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.963031\/full \uff09 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