{"id":75446,"date":"2022-08-10T09:26:00","date_gmt":"2022-08-10T02:26:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2022081009260075446"},"modified":"2022-08-10T22:10:09","modified_gmt":"2022-08-10T14:10:09","slug":"%e5%86%8d%e9%bc%8e%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%832022%e5%b9%b4%e7%ac%ac%e4%ba%8c%e5%ad%a3%e5%ba%a6%e8%b4%a2%e5%8a%a1%e4%b8%9a%e7%bb%a9%e5%92%8c%e5%85%ac%e5%8f%b8%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2022081009260075446","title":{"rendered":"\u518d\u9f0e\u533b\u836f\u516c\u5e032022\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u8d22\u52a1\u4e1a\u7ee9\u548c\u516c\u53f8\u8fdb\u5c55"},"content":{"rendered":"<ul type=\"disc\">\n<li><b><i>\u4ea7\u54c1\u7ba1\u7ebf\u8fbe\u6210\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u5305\u62ec<\/i><\/b><b><i>efgartigimod\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u548cKarXT 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Smiley\u8868\u793a\uff1a&nbsp;&quot;\u6211\u5f88\u9ad8\u5174\u80fd\u5728\u8fd9\u4e00\u5173\u952e\u65f6\u523b\u52a0\u5165\u518d\u9f0e\u533b\u836f\u3002\u518d\u9f0e\u533b\u836f\u6b63\u51ed\u501f\u5176\u5728\u4e9a\u6d32\u7684\u51fa\u8272\u5546\u4e1a\u5316\u8868\u73b0\u548c\u5168\u7403\u4ea7\u54c1\u5f00\u53d1\uff0c\u9614\u6b65\u6210\u957f\u4e3a\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\u3002\u518d\u9f0e\u533b\u836f\u4e13\u6709\u7814\u53d1\u7ba1\u7ebf\u7684\u8fdb\u5c55\u548c\u4ea7\u54c1\u7ec4\u5408\u7684\u591a\u6837\u6027\uff0c\u7a81\u7834\u4e86\u5176\u5728\u80bf\u7624\u9886\u57df\u7684\u4f20\u7edf\u4f18\u52bf\uff0c\u4e3a\u672a\u6765\u53d1\u5c55\u5e26\u6765\u5de8\u5927\u7684\u673a\u9047\u3002\u6211\u671f\u5f85\u4e0e\u8fd9\u4e00\u4f18\u79c0\u7684\u56e2\u961f\u5408\u4f5c\uff0c\u5e2e\u52a9\u516c\u53f8\u62d3\u5c55\u5728\u4e2d\u7f8e\u4e24\u5730\u7684\u4e1a\u52a1\u3002&quot;<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\u53ca\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6<\/b><\/p>\n<p><b>\u80bf\u7624\u9886\u57df<\/b><\/p>\n<p><b>\u5219\u4e50<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u5c3c\u62c9\u5e15\u5229\uff09<\/b><\/p>\n<p>\u5219\u4e50\u662f\u4e00\u79cd\u53e3\u670d\u3001\u6bcf\u65e5\u4e00\u6b21\u7684\u5c0f\u5206\u5b50\u805aADP-\u6838\u7cd6\uff08PARP\uff091\/2\u6291\u5236\u5242\uff0c\u662f\u76ee\u524d\u552f\u4e00\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u5730\u533a\u548c\u4e2d\u56fd\u5185\u5730\uff08\u4ee5\u4e0b\u7b80\u79f0&quot;\u4e2d\u56fd&quot;\uff09\u83b7\u6279\u7684\u65e0\u8bba\u60a3\u8005\u751f\u7269\u6807\u8bb0\u7269\u72b6\u6001\u5982\u4f55\uff0c\u5747\u53ef\u5355\u836f\u7528\u4e8e\u665a\u671f\u5375\u5de2\u764c\u6cbb\u7597\u7684PARP\u6291\u5236\u5242\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u5c3c\u62c9\u5e15\u5229\u7528\u4e8e\u4e2d\u56fd\u5375\u5de2\u764c\u60a3\u80053\u671f\u4e34\u5e8a\u7814\u7a76\uff08PRIME\uff09\u7684\u4e00\u9879\u65b0\u7684\u9884\u8bbe\u4e9a\u7ec4\u7ed3\u679c\uff0c\u5206\u6790\u4e86\u7814\u7a76\u5165\u7ec4\u7684384\u540d\u7ecf\u8fc7\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u540e\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u6216\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u7684\u65b0\u8bca\u65adIII\u671f\u6216IV\u671f\u5375\u5de2\u764c\u60a3\u8005\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5728\u5b8c\u5168\u7f13\u89e3\u7ec4\u4e2d\uff1a\u5c3c\u62c9\u5e15\u5229\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u4e3a29.4\u4e2a\u6708\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a8.3\u4e2a\u6708\uff08HR=0.45\uff1b95% CI\uff0c0.32\u20130.61\uff1bP&lt;0.001\uff09\u3002<\/li>\n<li>\u5728\u90e8\u5206\u7f13\u89e3\u7ec4\u4e2d\uff0c\u5c3c\u62c9\u5e15\u5229\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a19.3\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a8.3\u4e2a\u6708\uff08HR=0.45\uff1b95% CI\uff0c0.23\u20130.86\uff1bP=0.014\uff09\u3002<\/li>\n<li>\u5c3c\u62c9\u5e15\u5229\u7684\u5b89\u5168\u6027\u4e0e\u4e4b\u524d\u7684\u4e34\u5e8a\u7814\u7a76\u4e00\u81f4\uff0c\u5728\u8be5\u4e9a\u7ec4\u5206\u6790\u4e2d\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002<\/li>\n<\/ul>\n<p><b>\u80bf\u7624\u7535\u573a\u6cbb\u7597<\/b><\/p>\n<p>\u80bf\u7624\u7535\u573a\u6cbb\u7597\u662f\u4e00\u79cd\u5e72\u6270\u80bf\u7624\u7ec6\u80de\u5206\u88c2\u7684\u7535\u573a\u7597\u6cd5\u3002\u80bf\u7624\u7535\u573a\u6cbb\u7597\u8bbe\u5907\u7231\u666e\u76fe\u548cOptune Lua\uff0c\u5df2\u5728\u4e00\u4e9b\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u6279\u6216\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u65b0\u8bca\u65ad\u53ca\u590d\u53d1\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u53ca\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u548cNovocure\u5ba3\u5e032\u671f\u521d\u6b65\u4e34\u5e8a\u7814\u7a76EF-31\u8fbe\u5230\u4e86\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u4e5f\u663e\u793a\u79ef\u6781\u4fe1\u53f7\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u80bf\u7624\u7535\u573a\u6cbb\u7597\uff08TTFields\uff09\u8054\u5408\u6807\u51c6\u6cbb\u7597\uff08\u5316\u7597\u5355\u836f\u6216\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597HER2\u9633\u6027\u60a3\u8005\uff09\u4f5c\u4e3a\u80c3\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u7231\u666e\u76fe\u5df2\u88ab\u5217\u516550\u4e2a\u57ce\u5e02\u666e\u60e0\u9669\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u9884\u8ba1\u5b8c\u62103\u671f\u5173\u952e\u4e34\u5e8a\u7814\u7a76METIS\u6700\u540e\u4e00\u4f4d\u60a3\u8005\u5165\u7ec4\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u7acb\u4f53\u5b9a\u5411\u653e\u7597\u8054\u5408\u80bf\u7624\u7535\u573a\u6cbb\u7597\u5bf9\u6bd4\u5355\u72ec\u4f7f\u7528\u7acb\u4f53\u5b9a\u5411\u653e\u7597\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8111\u8f6c\u79fb\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p><b>\u64ce\u4e50<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u745e\u6d3e\u66ff\u5c3c\uff09<\/b><\/p>\n<p>\u64ce\u4e50\u662f\u4e00\u6b3e\u5f00\u5173\u63a7\u5236\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u7ecf\u8bbe\u8ba1\u4ee5\u5e7f\u6cdb\u6291\u5236\u7a81\u53d8\u7684KIT\u53caPDGFR\u03b1\u6fc0\u9176\uff0c\u662f\u76ee\u524d\u552f\u4e00\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6240\u6709\u66fe\u63a5\u53d7\u8fc7\u4e09\u79cd\u6216\u4ee5\u4e0a\u6fc0\u9176\u6291\u5236\u5242\u6cbb\u7597\u7684\u665a\u671f\u80c3\u80a0\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u7597\u6cd5\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u81ea2021\u5e745\u6708\u5728\u4e2d\u56fd\u5185\u5730\u5546\u4e1a\u4e0a\u5e02\u4ee5\u6765\uff0c\u64ce\u4e50\u5df2\u88ab\u5217\u516573\u4e2a\u57ce\u5e02\u666e\u60e0\u9669\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u4e89\u53d6\u5c06\u64ce\u4e50\u7528\u4e8e\u56db\u7ebf\u80c3\u80a0\u95f4\u8d28\u7624\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff08NRDL\uff09\u3002<\/p>\n<p><b>Adagrasib<\/b><\/p>\n<p>Adagrasib\u662f\u4e00\u6b3e\u9ad8\u9009\u62e9\u6027\u7684\u5f3a\u6548\u53e3\u670d\u5c0f\u5206\u5b50KRAS<sup>G12C<\/sup>\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u3001\u80f0\u817a\u764c\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5b8c\u6210\u5168\u74033\u671f\u4e34\u5e8a\u7814\u7a76KRYSTAL-12\u5927\u4e2d\u534e\u533a\u9996\u4f4d\u60a3\u8005\u7ed9\u836f\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u7528\u4e8eKRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5b8c\u6210\u5168\u74033\u671f\u4e34\u5e8a\u7814\u7a76KRYSTAL-10\u5927\u4e2d\u534e\u533a\u9996\u4f4d\u60a3\u8005\u7ed9\u836f\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u7528\u4e8eKRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u665a\u671fCRC\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Mirati Therapeutics, Inc.\uff08Mirati\uff09\u57282022\u5e74ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u4ee5\u4e0b\u4fe1\u606f\uff1a<\/p>\n<ul type=\"disc\">\n<li>Mirati\u62a5\u544a\u4e862\u671f\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76KRYSTAL-1\u7684\u5b8c\u6574\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u7528\u4e8e\u7ecf\u6cbb\u7684\u5177\u6709KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684NSCLC\u60a3\u8005\uff0c\u76f8\u5173\u7ed3\u679c\u540c\u65f6\u53d1\u8868\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u3002\u8be5\u7ed3\u679c\u5305\u62ec\u6765\u81ea2\u671fKRYSTAL-1\u7814\u7a76\u7684NSCLC\u961f\u5217\u7684\u56de\u987e\u6027\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u7528\u4e8e\u5177\u6709KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684NSCLC\u60a3\u8005\u548c\u7a33\u5b9a\u7684\u3001\u7ecf\u6cbb\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8f6c\u79fb\u7684\u60a3\u8005\u3002<\/li>\n<ul type=\"disc\">\n<li>2\u671f\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u7efc\u8ff0\uff08n=112\uff09\uff1a\u521d\u6b65\u7ed3\u679c\u663e\u793a\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a43%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a80%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08mDOR\uff09\u4e3a8.5\u4e2a\u6708\uff0895% CI\uff1a6.2\u201313.8\uff09\uff0cmPFS\u4e3a6.5\u4e2a\u6708\uff0895% CI\uff1a4.7\u20138.4\uff09\u3002\u622a\u81f32022\u5e741\u670815\u65e5\u7684\u6570\u636e\u663e\u793a\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09\u4e3a12.6\u4e2a\u6708\uff0895% CI\uff1a9.2\u201319.2\uff09\u3002<\/li>\n<li>\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u7279\u5f02\u6027\u6d3b\u6027\uff08n=33\uff09\u5728\u7a33\u5b9a\u7684\u3001\u7ecf\u6cbb\u7684CNS\u8f6c\u79fb\u7076\u5b50\u96c6\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\uff1a\u7ed3\u679c\u663e\u793a\u9885\u5185\uff08IC\uff09\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a33%\uff0811\/33\uff09\u3002<\/li>\n<\/ul>\n<li>\u6b64\u5916\uff0cMirati\u62a5\u544a\u4e86KRYSTAL-1\u7814\u7a76\u6c47\u603b\u5206\u6790\u7684\u6700\u65b0\u7ed3\u679c\uff0c\u5305\u62ec\u6ce8\u518c\u60272\u671f\u548c1\/1b\u671fNSCLC\u961f\u5217\u3002<\/li>\n<ul type=\"disc\">\n<li>KRYSTAL-1 NSCLC\u961f\u5217\uff08n=132\uff09\u7684\u6c47\u603b\u5206\u6790\uff1a\u521d\u6b65\u7ed3\u679c\u663e\u793aORR\u4e3a44%\uff0cDCR\u4e3a81%\u3002mDOR\u4e3a12.5\u4e2a\u6708\uff0cmPFS\u4e3a6.9\u4e2a\u6708\u3002\u622a\u81f32022\u5e741\u670815\u65e5\u7684\u6570\u636e\u663e\u793a\uff0cmOS\u4e3a14.1\u4e2a\u6708\u3002<\/li>\n<\/ul>\n<\/ul>\n<p>2022\u5e746\u6708\uff0cMirati\u8fd8\u516c\u5e03\u4e86KRYSTAL-1\u7814\u7a761b\u671f\u961f\u5217\u7684\u524d\u77bb\u6027\u5206\u6790\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u7528\u4e8e\u5177\u6709KRAS<sup>G12C<\/sup>\u7a81\u53d8\u4e14\u4f34\u6709\u6d3b\u52a8\u6027\u548c\u521d\u6cbb\u7684CNS\u8f6c\u79fb\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u9885\u5185\u53cd\u5e94\u3002<\/p>\n<ul type=\"disc\">\n<li>\u6d3b\u52a8\u6027\u548c\u521d\u6cbb\u7684CNS\u8f6c\u79fb\u7076\u4e2d\u7684CNS\u7279\u5f02\u6027\u6d3b\u6027(n=19)\uff1a\u7ed3\u679c\u663e\u793a\u9885\u5185ORR\u4e3a32%\uff086\/19\uff09\u3002<\/li>\n<\/ul>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u4e8e2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u66f4\u65b02\u671f\u7814\u7a76KRYSTAL-7\u7684\u8010\u53d7\u6027\u548cORR\u6570\u636e\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u4e8e\u4e00\u7ebfKRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684NSCLC\u6cbb\u7597\u3002<\/p>\n<p>\u8fdb\u4e00\u6b65\u660e\u786eadagrasib\u5355\u836f\u4e00\u7ebf\u6cbb\u7597KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684NSCLC\u7684\u6ce8\u518c\u8def\u5f84\uff0c\u4ee5\u53ca\u9488\u5bf9NSCLC\u4ee5\u5916\u7684\u7624\u79cd\u7684\u4e0b\u4e00\u6b65\u8ba1\u5212\u3002<\/p>\n<p>Adagrasib\u6709\u671b\u83b7\u5f97FDA\uff08\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff09\u6279\u51c6\u5e76\u5546\u4e1a\u5316\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u66fe\u7ecf\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u6b21\u7cfb\u7edf\u6027\u6cbb\u7597\u7684KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684NSCLC\u60a3\u8005\uff1b\u5904\u65b9\u836f\u7528\u6237\u4ed8\u8d39\u6cd5\u6848\uff08PDUFA\uff09\u7684\u76ee\u6807\u884c\u52a8\u65e5\u671f\u4e3a2022\u5e7412\u670814\u65e5\u3002<\/p>\n<p><b>Bemarituzumab<\/b><\/p>\n<p>Bemarituzumab\u662f\u4e00\u6b3e\u5177\u6709\u540c\u7c7b\u9996\u521b\u6f5c\u529b\u7684\u6297\u4f53\uff0c\u4f5c\u4e3a\u9488\u5bf9FGFR2b\u8fc7\u5ea6\u8868\u8fbe\u7684\u80bf\u7624\u9776\u5411\u7597\u6cd5\uff0c\u6b63\u5728\u8fdb\u884c\u9488\u5bf9\u80c3\u764c\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u90e8\uff08GEJ\uff09\u764c\u7684\u5f00\u53d1\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34\u5b89\u8fdb\u62a5\u544a\uff0c2\u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5bf9\u7167\u7814\u7a76FIGHT\u7684\u6700\u7ec8\u5206\u6790\u5df2\u7ecf\u5b8c\u6210\uff0c\u8be5\u9879\u7814\u7a76\u65e8\u5728\u8bc4\u4f30bemarituzumab\u8054\u5408\u6539\u826f\u7684FOLFOX6\uff08mFOLFOX6\uff09\u7528\u4e8e\u521d\u6cbb\u7684\u665a\u671f\u80c3\u764c\u548c\u80c3\u98df\u7ba1\u4ea4\u754c\u90e8\u764c\u60a3\u8005\u3002\u8fd9\u4e9b\u7ed3\u679c\u7ee7\u7eed\u8bc1\u660ebemarituzumab\u8054\u5408mFOLFOX6\u6539\u5584\u4e86\u8868\u8fbeFGFR2b\u7684\u80bf\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u6ca1\u6709\u65b0\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u968f\u7740FGFR2b\u8868\u8fbe\u6c34\u5e73\u7684\u589e\u52a0\uff0c\u89c2\u5bdf\u5230\u66f4\u5927\u7684\u751f\u5b58\u83b7\u76ca\u3002<\/p>\n<p>\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34\u5b89\u8fdb\u5df2\u7ecf\u542f\u52a8\u4e86\u4e00\u98791b\/2\u671f\u7814\u7a76\uff08FORTITUDE-301\uff09\uff0c\u8bc4\u4f30bemarituzumab\u5355\u836f\u7528\u4e8eFGFR2b\u8fc7\u5ea6\u8868\u8fbe\u5b9e\u4f53\u7624\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u4e8e2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u5728\u5927\u4e2d\u534e\u533a\u542f\u52a8\u4e00\u9879\u8bc4\u4f30bemarituzumab\u7528\u4e8e\u4e00\u7ebf\u665a\u671f\u80c3\u764c\u548cGEJ\u764c\u6cbb\u7597\u7684\u6ce8\u518c\u6027\u7814\u7a76\u3002<\/p>\n<p><b>Odronextamab<\/b><\/p>\n<p>Odronextamab\u662f\u4e00\u6b3e\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u65e8\u5728\u901a\u8fc7\u8fde\u63a5\u5e76\u6d3b\u5316\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08\u4e0eCD3\u7ed3\u5408\uff09\u53ca\u6dcb\u5df4\u7624\u7ec6\u80de\uff08\u4e0eCD20\u7ed3\u5408\uff09\uff0c\u89e6\u53d1\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u5b8c\u6210B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08B-NHL\uff09\u6f5c\u5728\u5173\u952e2\u671f\u7814\u7a76\u7684\u5165\u7ec4\u3002<\/p>\n<p>\u516c\u5e03\u7528\u4e8eB-NHL\u6cbb\u7597\u7684\u6f5c\u5728\u5173\u952e2\u671f\u7814\u7a76\u7684\u8fdb\u4e00\u6b65\u7ed3\u679c\uff0c\u5e76\u5411FDA\u63d0\u4ea4\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\u3002<\/p>\n<p><b>Repotrectinib<\/b><\/p>\n<p>Repotrectinib\u662f\u65b0\u4e00\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u80fd\u6709\u6548\u9776\u5411\u4f5c\u7528\u4e8eROS1\u53caTRK &nbsp;A\/B\/C\uff0c\u5bf9\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7TKI\u6cbb\u7597\u6216TKI\u7ecf\u6cbb\u7684\u60a3\u8005\u5747\u6709\u6cbb\u7597\u6f5c\u529b\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Turning Point Therapeutics, Inc.\uff08Turning Point\uff09\u5ba3\u5e03\u5728\u7b2c\u4e8c\u5b63\u5ea6\u4e3e\u884c\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u524d\u4f1a\u8bae\u4e0a\u6536\u5230FDA\u7684\u79ef\u6781\u53cd\u9988\u3002FDA\u540c\u610fTurning Point\u5728\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u65f6\uff0c\u63d0\u4ea4ROS1\u9633\u6027\u7684TKI\u521d\u6cbb\u548cTKI\u7ecf\u6cbb\u7684\u665a\u671fNSCLC\u60a3\u8005\u81ea\u7b2c\u4e00\u6b21\u57fa\u7ebf\u540e\u626b\u63cf\u5f00\u59cb\u7684\u81f3\u5c11\u516d\u4e2a\u6708\u968f\u8bbf\u6570\u636e\u7684\u8ba1\u5212\u3002<\/p>\n<p>2022\u5e746\u6708\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u6388\u4e88repotrectinib\u4e24\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff08BTD\uff09\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc71\u4e2a\u524d\u7ebfROS1 TKI\u548c1\u4e2a\u524d\u7ebf\u542b\u94c2\u5316\u7597\u7684ROS1\u9633\u6027\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u8fc71\u4e2a\u524d\u7ebfROS1 TKI\u5e76\u4e14\u672a\u63a5\u53d7\u5316\u7597\u6216\u514d\u75ab\u6cbb\u7597\u7684ROS1\u9633\u6027\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u3002<\/p>\n<p>2022\u5e745\u6708\uff0c\u518d\u9f0e\u533b\u836f\u548cTurning Point\u5ba3\u5e03FDA\u6388\u4e88repotrectinib\u7b2c\u516b\u4e2a\u6ce8\u518c\u8ba4\u5b9a\u66a8\u7b2c\u4e09\u4e2a\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u6b64\u524d\u63a5\u53d7\u8fc7\u4e00\u79cdROS1 TKI\u6cbb\u7597\u548c\u4e4b\u524d\u672a\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684ROS1\u9633\u6027\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u5b8c\u62101\/2\u671f\u6ce8\u518c\u6027\u7814\u7a76TRIDENT-1\u6240\u6709\u961f\u5217\u7684\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n<p>\u9884\u8ba1\u5728\u5373\u5c06\u53ec\u5f00\u7684\u533b\u5b66\u4f1a\u8bae\u4e0a\uff0c\u8be6\u7ec6\u66f4\u65b0\u7ecfBICR\u5206\u6790\u7684TRIDENT-1\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5305\u62ec\u9885\u5185\u6d3b\u6027\u7684\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n<p>\u63d0\u4f9bTRIDENT-1\u7814\u7a76\u4e2dNTRK\u9633\u6027\u665a\u671f\u5b9e\u4f53\u7624\u961f\u5217\u7684\u4e34\u5e8a\u6570\u636e\u66f4\u65b0\u3002<\/p>\n<p><b>CLN-081<\/b><\/p>\n<p>CLN-081\u662f\u4e00\u6b3e\u53e3\u670d\u3001\u4e0d\u53ef\u9006\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u9776\u5411\u4f5c\u7528\u4e8eEGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\uff0c\u540c\u65f6\u907f\u5f00\u8868\u8fbe\u91ce\u751f\u578bEGFR\u7684\u7ec6\u80de\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Cullinan Oncology\u57282022\u5e74ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u9488\u5bf9EGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u7684NSCLC\u60a3\u8005\u76841\/2a\u671f\u7814\u7a76\u7684\u66f4\u65b0\u6570\u636e\u3002\u5728100mg\u6bcf\u65e5\u4e24\u6b21\u5242\u91cf\u7ec4\u768439\u540d\u60a3\u8005\u4e2d\uff1a<\/p>\n<ul type=\"disc\">\n<li>16\u540d\uff0841%\uff09\u60a3\u8005\u786e\u5b9a\u90e8\u5206\u7f13\u89e3\u3002<\/li>\n<li>\u9884\u4f30\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u8d85\u8fc721\u4e2a\u6708\u3002<\/li>\n<li>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a12\u4e2a\u6708\u3002<\/li>\n<li>CLN-081\u7684\u5b89\u5168\u6027\u4f7f\u5176\u53ef\u7528\u4e8e\u957f\u671f\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u5728\u5b8c\u6210\u98df\u7269\u6548\u5e94\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u7814\u7a76\u540e\uff0c\u542f\u52a8\u5173\u952e\u6027\u7814\u7a76\u3002<\/p>\n<p><b>Elzovantinib (TPX-0022)<\/b><\/p>\n<p>Elzovantinib\u662f\u4e00\u6b3e\u53e3\u670d\u591a\u9776\u70b9\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5177\u6709\u65b0\u578b\u4e09\u7ef4\u5927\u73af\u7ed3\u6784\uff0c\u53ef\u6291\u5236MET\u3001CSF1R\uff08\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\u53d7\u4f53\uff09\u53caSRC\u6fc0\u9176\u3002&nbsp;<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u5168\u74031\/2\u671f\u4e34\u5e8a\u7814\u7a76SHIELD-1\u76841\u671f\u6269\u5c55\u90e8\u5206\u5b8c\u6210\u5927\u4e2d\u534e\u533a\u9996\u4f4d\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n<p>\u63d0\u4f9bSHIELD-1 1\u671f\u7814\u7a76\u7684\u4e34\u5e8a\u6570\u636e\u66f4\u65b0\u3002<\/p>\n<p>\u89c6FDA\u5bf9\u4e2d\u7b49\u5242\u91cf\u6c34\u5e73\u6570\u636e\u7684\u53cd\u9988\u800c\u5b9a\uff0c\u542f\u52a8SHIELD-1\u4e34\u5e8a\u7814\u7a76\u76842\u671f\u90e8\u5206\u3002<\/p>\n<p><b>BLU-945<\/b><\/p>\n<p>BLU-945\u662f\u4e00\u6b3e\u5904\u4e8e\u7814\u7a76\u9636\u6bb5\u7684\u9009\u62e9\u6027\u3001\u5f3a\u6548\u7684EGFR\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u6291\u5236L858R\u6d3b\u5316\u7a81\u53d8\u621619\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u4f34\u6709\u83b7\u5f97\u6027T790M\u548cC797S\u7a81\u53d8\uff0c\u8fd9\u4e9b\u7a81\u53d8\u5206\u522b\u662f\u7b2c\u4e00\u4ee3EGFR\u6291\u5236\u5242\u548c\u5965\u5e0c\u66ff\u5c3c\u5e38\u89c1\u7684\u9776\u5185\u8010\u836f\u7a81\u53d8\u3002BLU-945\u6709\u671b\u7528\u4e8e\u6cbb\u7597EGFR\u9a71\u52a8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u83b7\u5f97\u4e86\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5bf9\u5168\u74031\/2\u671f\u4e34\u5e8a\u7814\u7a76SYMPHONY\u4e2dBLU-945\u5355\u836f\u961f\u5217\u5728\u5927\u4e2d\u534e\u533a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u516c\u5e03\u9488\u5bf9EGFR\u7a81\u53d8NSCLC\u60a3\u8005\u76841\/2\u671f\u4e34\u5e8a\u7814\u7a76SYMPHONY\u4e2d\u7684BLU-945\u5355\u836f\u6cbb\u7597\u7684\u66f4\u65b0\u6570\u636e\uff0c\u4ee5\u53ca\u4e0e\u5965\u5e0c\u66ff\u5c3c\u8054\u7528\u7684\u5242\u91cf\u9012\u589e\u961f\u5217\u7684\u521d\u6b65\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n<p>\u57281\/2\u671f\u4e34\u5e8a\u7814\u7a76SYMPHONY\u4e2d\u542f\u52a8\u66f4\u591a\u961f\u5217\uff0c\u7528\u4e8e\u8bc4\u4f30BLU-945\u5728\u591a\u4e2a\u60a3\u8005\u4eba\u7fa4\u4e2d\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\uff0c\u5305\u62ec\u524d\u7ebf\u6cbb\u7597\u3002<\/p>\n<p><b>BLU-701<\/b><\/p>\n<p>BLU-701\u662f\u4e00\u6b3e\u5904\u4e8e\u7814\u7a76\u9636\u6bb5\u7684\u9009\u62e9\u6027\u3001\u5f3a\u6548\u7684EGFR\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u6291\u5236L858R\u6d3b\u5316\u7a81\u53d8\u621619\u5916\u663e\u5b50\u7f3a\u5931\u7a81\u53d8\u4f34\u6709\u83b7\u5f97\u6027C797S\u7a81\u53d8\uff0c\u8fd9\u4e9b\u7a81\u53d8\u662f\u5965\u5e0c\u66ff\u5c3c\u5e38\u89c1\u7684\u9776\u5185\u8010\u836f\u7a81\u53d8\u3002BLU-701\u6709\u671b\u7528\u4e8e\u6cbb\u7597EGFR\u9a71\u52a8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u516c\u5e03BLU-701\u6cbb\u7597EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u76841\/2\u671f\u4e34\u5e8a\u7814\u7a76HARMONY\u7684\u521d\u6b65\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n<p><b>\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9886\u57df<\/b><\/p>\n<p><b>VYVGART<\/b><sup>&reg;<\/sup><b>\uff08<\/b><b>Efgartigimod\uff09<\/b><\/p>\n<p>Efgartigimod\u662f\u4e00\u6b3e\u6297\u4f53\u7247\u6bb5\uff0c\u65e8\u5728\u51cf\u5c11\u81f4\u75c5\u6027\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u81ea\u8eab\u6297\u4f53\u5e76\u963b\u65adIgG\u5faa\u73af\u5229\u7528\u8fc7\u7a0b\u3002\u5176\u4e0e\u65b0\u751f\u513fFc\u53d7\u4f53\uff08FcRn\uff09\u7ed3\u5408\uff0c\u8be5\u53d7\u4f53\u5728\u5168\u8eab\u90fd\u6709\u5e7f\u6cdb\u8868\u8fbe\uff0c\u5728\u963b\u6b62IgG\u964d\u89e3\u7684\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u6838\u5fc3\u4f5c\u7528\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5ba3\u5e03efgartigimod\u6ce8\u5c04\u6db2\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u5168\u8eab\u578b\u91cd\u75c7\u808c\u65e0\u529b\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\u3002<\/p>\n<p>2022\u5e746\u6708\uff0cefgartigimod\u843d\u5730\u6d77\u5357\u535a\u9ccc\u4e50\u57ce\u56fd\u9645\u533b\u7597\u65c5\u6e38\u5148\u884c\u533a\u30022022\u5e747\u6708\uff0c\u9996\u4f4d\u4e2d\u56fd\u60a3\u8005\u63a5\u53d7\u4e86efgartigimod\u6cbb\u7597\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u542f\u52a8\u9488\u5bf9\u4e24\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u80be\u75c5\u7684\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u3002<\/p>\n<p>\u4e0eargenx\u5408\u4f5c\u7ee7\u7eed\u63a2\u7d22\u548c\u63a8\u8fdb\u5176\u4ed6\u9002\u5e94\u8bc1\u7684\u7814\u7a76\u3002<\/p>\n<p>\u4e8e2022\u5e74\u7b2c\u4e09\u5b63\u5ea6\u542f\u52a8\u9488\u5bf9\u7279\u53d1\u6027\u708e\u6027\u808c\u75c5\uff08\u808c\u708e\uff09\u7684\u4e09\u79cd\u4e9a\u578b\uff08\u5305\u62ec\u514d\u75ab\u4ecb\u5bfc\u574f\u6b7b\u6027\u808c\u75c5\u3001\u6297\u5408\u6210\u9176\u7efc\u5408\u75c7\u548c\u76ae\u808c\u708e\uff09\u7684\u6ce8\u518c\u6027\u7814\u7a76ALKIVIA\uff1b\u8ba1\u5212\u9488\u5bf9\u6bcf\u79cd\u4e9a\u578b\u7684\u524d30\u540d\u60a3\u8005\u7684\u6570\u636e\u8fdb\u884c\u4e2d\u671f\u5206\u6790\u3002<\/p>\n<p>\u5411FDA\u9012\u4ea4efgartigimod\u76ae\u4e0b\u6ce8\u5c04\u5242\u578b\u6cbb\u7597\u5168\u8eab\u578b\u91cd\u75c7\u808c\u65e0\u529b\u7684\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\u3002<\/p>\n<p><b>\u6297\u611f\u67d3\u9886\u57df<\/b><\/p>\n<p><b>\u7ebd\u518d\u4e50<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u7532\u82ef\u78fa\u9178\u5965\u9a6c\u73af\u7d20\uff09<\/b><\/p>\n<p>\u7ebd\u518d\u4e50\u662f\u4e00\u6b3e\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u6216\u9759\u8109\u7ed9\u836f\u7684\u6297\u751f\u7d20\uff0c\u7528\u4e8e\u6cbb\u7597\u5c0f\u533a\u83b7\u5f97\u6027\u7ec6\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\u53ca\u6025\u6027\u7ec6\u83cc\u6027\u76ae\u80a4\u548c\u76ae\u80a4\u7ed3\u6784\u611f\u67d3\uff08ABSSSI\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002\u518d\u9f0e\u533b\u836f\u8d1f\u8d23\u5176\u5728\u4e2d\u56fd\u7684\u5f00\u53d1\uff0c\u5e76\u4e8e2021\u5e7412\u6708\u83b7\u5f97NMPA\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u4e89\u53d6\u5c06\u7ebd\u518d\u4e50CABP\u548cABSSSI\u9002\u5e94\u8bc1\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002<\/p>\n<p>\u63d0\u4ea4\u518d\u9f0e\u533b\u836f\u7684\u4e0a\u5e02\u540e\u7814\u7a76\u8ba1\u5212\u3002<\/p>\n<p><b>\u8212\u5df4\u5766<\/b><b>-Durlobactam<\/b><\/p>\n<p><b>(SUL-DUR\uff0c\u4e9a\u592a\u5730\u533a\u6743\u76ca\uff09<\/b><\/p>\n<p>\u8212\u5df4\u5766-Durlobactam\u662f\u4e00\u6b3e\u03b2-\u5185\u9170\u80fa\u2571\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242\u7684\u7ec4\u5408\u578b\u65b0\u836f\uff0c\u5bf9\u4e8e\u5305\u62ec\u78b3\u9752\u9709\u70ef\u7c7b\u8010\u836f\u83cc\u682a\u5728\u5185\u7684\u9c8d\u66fc\u4e0d\u52a8\u6746\u83cc\u5177\u6709\u72ec\u7279\u6297\u83cc\u6d3b\u6027\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u4e8e2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u5411NMPA\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p>\u4e8e2022\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5411FDA\u63d0\u4ea4\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p><b>\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u9886\u57df<\/b><\/p>\n<p><b>KarXT<\/b><\/p>\n<p>KarXT\u5c06\u65b0\u578b\u6bd2\u8548\u78b1\u6fc0\u52a8\u5242\u546b\u8bfa\u7f8e\u6797\u4e0e\u5df2\u83b7\u6279\u7684\u6bd2\u8548\u78b1\u62ee\u6297\u5242\u66f2\u53f8\u6c2f\u94f5\u7ed3\u5408\u30022021\u5e7411\u6708\uff0c\u518d\u9f0e\u533b\u836f\u4e0eKaruna Therapeutics, Inc.\uff08Karuna\uff09\u5408\u4f5c\u5728\u5927\u4e2d\u534e\u533a\u5f00\u53d1KarXT\u7528\u4e8e\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u5176\u4ed6\u9002\u5e94\u8bc1\uff0c\u5982\u75f4\u5446\u76f8\u5173\u7684\u7cbe\u795e\u75c5\u6027\u969c\u788d\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>2022\u5e748\u6708\uff0c\u518d\u9f0e\u533b\u836f\u7684\u5408\u4f5c\u4f19\u4f34Karuna\u5ba3\u5e03\u4e863\u671f\u4e34\u5e8a\u7814\u7a76EMERGENT-2\u7684\u9633\u6027\u521d\u6b65\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u5176\u5728\u6210\u4eba\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u5176\u4e3b\u8981\u7ec8\u70b9\uff0c\u5728\u7b2c\u4e94\u5468\u65f6\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cKarXT\u5728\u9633\u6027\u548c\u9634\u6027\u7efc\u5408\u75c7\u91cf\u8868\uff08PANSS\uff09\u603b\u5206\u964d\u4f4e\u4e86\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u76849.6\u5206\uff08-21.2 KarXT\u5bf9\u6bd4-11.6\u5b89\u6170\u5242\uff0cp&lt;0.0001\uff09\u3002\u4ece\u7b2c2\u5468\u5f00\u59cb\uff0c\u6839\u636ePANSS\u603b\u5206\u8bc4\u4f30\uff0cKarXT\u8fd8\u8868\u73b0\u51fa\u65e9\u671f\u548c\u6301\u7eed\u7684\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u75c7\u72b6\u51cf\u5c11\uff0c\u5e76\u6301\u7eed\u81f3\u7814\u7a76\u7ed3\u675f\u3002<\/p>\n<ul type=\"disc\">\n<li>\u8be5\u7814\u7a76\u4e5f\u8fbe\u5230\u4e86\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff0c\u901a\u8fc7PANSS\u9633\u6027\u75c7\u72b6\u3001PANSS\u9634\u6027\u75c7\u72b6\u548cPANSS Marder\u9634\u6027\u75c7\u72b6\u5206\u91cf\u8868\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u9633\u6027\u548c\u9634\u6027\u75c7\u72b6\u5747\u5b9e\u73b0\u5728\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u51cf\u5c11\u3002<\/li>\n<li>KarXT\u7684\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e0d\u826f\u53cd\u5e94\u7279\u5f81\u4e0e\u4e4b\u524d\u7684KarXT\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u4e2d\u7684\u7814\u7a76\u57fa\u672c\u4e00\u81f4\u3002<\/li>\n<\/ul>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u5c31\u7cbe\u795e\u5206\u88c2\u75c7\u6ce8\u518c\u76f8\u5173\u4e8b\u5b9c\u5411\u6ce8\u518c\u90e8\u95e8\u8fdb\u884c\u54a8\u8be2\u3002<\/p>\n<p>\u4e8e2022\u5e74\u7b2c\u4e09\u5b63\u5ea6\u542f\u52a8\u8bc4\u4f30KarXT\u6cbb\u7597\u963f\u8328\u6d77\u9ed8\u75c7\u7cbe\u795e\u75c5\u6027\u969c\u788d\u76843\u671fADEPT-1\u7814\u7a76\u3002<\/p>\n<p><b>\u5168\u7403\u7814\u53d1\u9879\u76ee<\/b><\/p>\n<p><b>ZL-1102<\/b><\/p>\n<p><b>(IL-17\u5168\u4eba\u6e90VH\u6297\u4f53\u7247\u6bb5\uff0c\u5168\u7403\u6743\u5229)<\/b><\/p>\n<p>ZL-1102\u662f\u4e00\u6b3e\u65b0\u578b\u5168\u4eba\u6e90VH\u6297\u4f53\u7247\u6bb5\uff08Humabody<sup>&reg;<\/sup>\uff09\uff0c\u9776\u5411\u4f5c\u7528\u4e8eIL-17A\u7ec6\u80de\u56e0\u5b50\uff0c\u5177\u6709\u9ad8\u4eb2\u548c\u529b\u548c\u6d3b\u6027\u3002\u6709\u522b\u4e8e\u5176\u4ed6\u6297IL-17\u4ea7\u54c1\uff0cZL-1102\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u8f7b\u4e2d\u5ea6\u6162\u6027\u6591\u5757\u72b6\u94f6\u5c51\u75c5\uff08CPP\uff09\u7684\u5c40\u90e8\u6cbb\u7597\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n<p>\u8bc4\u4f30ZL-1102\u5728\u8f7b\u4e2d\u5ea6CPP\u60a3\u8005\u4e2d\u7597\u6548\u548c\u5b89\u5168\u6027\u76841\u671f\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u5df2\u5165\u90092022\u5e749\u67087\u65e5\u201310\u65e5\u7684EADV\uff08\u6b27\u6d32\u76ae\u80a4\u75c5\u5b66\u548c\u6027\u75c5\u5b66\u4f1a\uff09\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\u3002<\/p>\n<p><b>2022\u5e74\u9884\u671f\u91cc\u7a0b\u7891\uff1a<\/b><\/p>\n<p>\u4e8e2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u542f\u52a8\u7528\u4e8eCPP\u6cbb\u7597\u7684\u5168\u74032\u671f\u7814\u7a76\u3002<\/p>\n<p><b>Simurosertib, ZL-2309<\/b><\/p>\n<p><b>(CDC7\u6291\u5236\u5242\uff0c\u5168\u7403\u6743\u5229)<\/b><\/p>\n<p>Simurosertib\uff08\u53c8\u79f0ZL-2309\uff09\u662f\u4e00\u6b3e\u53e3\u670d\u3001\u9009\u62e9\u6027CDC7\u6291\u5236\u5242\u3002CDC7\u662f\u4e00\u79cd\u86cb\u767d\u6fc0\u9176\uff0c\u5728 DNA\u590d\u5236\u548c\u7ed5\u8fc7DNA\u635f\u4f24\u53cd\u5e94\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u8fdb\u5c55\uff1a<\/b><\/p>\n<p>\u57fa\u4e8e\u5bf9\u6b64\u524d\u5b8c\u6210\u7684\u7814\u7a76\u4e2d\u6536\u96c6\u7684\u6570\u636e\u7684\u5168\u9762\u8bc4\u4f30\uff0c\u518d\u9f0e\u533b\u836f\u51b3\u5b9a\u7ec8\u6b62simurosertib\u7814\u7a76\u7684\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n<p><b>ZL-1201<\/b><\/p>\n<p><b>(CD47\u6291\u5236\u5242\uff0c\u5168\u7403\u6743\u5229)<\/b><\/p>\n<p>ZL-1201\u662f\u4e00\u6b3e\u7ecf\u5de5\u7a0b\u5316\u6539\u826f\u964d\u4f4e\u4e86\u6548\u5e94\u529f\u80fd\uff0c\u7279\u5f02\u6027\u9776\u5411CD47\u7684\u4eba\u6e90\u5316IgG4\u5355\u514b\u9686\u6297\u4f53\u3002ZL-1201\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u5c06\u5728\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e2d\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<p><b>\u8fd1\u671f\u4ea7\u54c1\u8fdb\u5c55\uff1a<\/b><\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u901a\u8fc7\u6b63\u5728\u8fdb\u884c\u76841\u671f\u4e34\u5e8a\u7814\u7a76\u786e\u5b9a\u4e862\u671f\u63a8\u8350\u5242\u91cf\u3002<\/p>\n<p>\u57fa\u4e8e\u5bf9\u7ade\u4e89\u683c\u5c40\u7684\u8bc4\u4f30\uff0c\u518d\u9f0e\u533b\u836f\u51b3\u5b9a\u964d\u4f4eZL-1201\u7684\u5185\u90e8\u5f00\u53d1\u4f18\u5148\u7ea7\uff0c\u4f46\u5bf9\u4e8e\u5bf9\u5916\u6388\u6743\u6301\u5f00\u653e\u6001\u5ea6\u3002<\/p>\n<p><b>\u516c\u53f8\u6700\u65b0\u52a8\u6001<\/b><\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5b8c\u6210\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u7531\u7b2c\u4e8c\u4e0a\u5e02\u81ea\u613f\u8f6c\u6362\u4e3a\u4e3b\u8981\u4e0a\u5e02\u3002\u518d\u9f0e\u533b\u836f\u73b0\u5728\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u548c\u7eb3\u65af\u8fbe\u514b\u53cc\u91cd\u4e3b\u8981\u4e0a\u5e02\u7684\u516c\u53f8\u3002<\/p>\n<p>2022\u5e746\u6708\u548c7\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4ea4\u6613\u7684\u666e\u901a\u80a1\u5206\u522b\u88ab\u7eb3\u5165\u6df1\u6e2f\u901a\u548c\u6caa\u6e2f\u901a\u80a1\u7968\u540d\u5355\u3002\u88ab\u7eb3\u5165\u6df1\u6e2f\u901a\u548c\u6caa\u6e2f\u901a\u5c06\u4fbf\u6377\u4e2d\u56fd\u5185\u5730\u7b26\u5408\u6761\u4ef6\u7684\u6295\u8d44\u8005\u5bf9\u518d\u9f0e\u533b\u836f\u53ca\u5176\u80a1\u7968\u7684\u6295\u8d44\u3002<\/p>\n<p>\u518d\u9f0e\u533b\u836f\u8058\u8bf7\u6bd5\u9a6c\u5a01\u4f1a\u8ba1\u5e08\u4e8b\u52a1\u6240\uff08KPMG LLP\uff09\u4f5c\u4e3a\u516c\u53f8\u7684\u5ba1\u8ba1\u673a\u6784\uff0c\u81ea2022\u5e745\u670831\u65e5\u8d77\u751f\u6548\u3002<span id=\"spanHghlt5025\">\u516c\u53f8<\/span>\u8ba4\u4e3a\uff0c\u4ece\u622a\u81f32022\u5e7412\u670831\u65e5\u6b62\u7684\u8d22\u5e74\u5e74\u5ea6\u62a5\u544a\u5f00\u59cb\uff0c<span id=\"spanHghlt7e67\">\u516c\u53f8<\/span>\u5c06\u7b26\u5408\u300a\u5916\u56fd\u516c\u53f8\u95ee\u8d23\u6cd5\u6848\u300b\uff08HFCAA\uff09\u7684\u8981\u6c42\uff0c\u5e76\u4e14<span id=\"spanHghlt5025\">\u516c\u53f8<\/span>\u57282023\u5e74\u6216\u5176\u540e\u5c06\u4e0d\u4f1a\u88ab\u5217\u5165HFCAA\u9879\u4e0b\u7684\u6700\u7ec8\u8ba4\u5b9a\u540d\u5355\u3002\u56e0\u6b64\u516c\u53f8\u9884\u8ba1\uff0c\u5176\u5728\u7eb3\u65af\u8fbe\u514b\u7684\u6302\u724c\u5c06\u4e0d\u4f1a\u4e2d\u65ad\u3002\u516c\u53f8\u5173\u4e8e\u8058\u8bf7\u6bd5\u9a6c\u5a01\u4f1a\u8ba1\u5e08\u4e8b\u52a1\u6240\u7684\u5b8c\u6574\u58f0\u660e\u53ef\u767b\u5f55\u518d\u9f0e\u533b\u836f\u5b98\u7f51\u7684\u6295\u8d44\u8005\u5173\u7cfb\u7248\u5757\u67e5\u8be2\u3002<\/p>\n<p>\u518d\u9f0e\u533b\u836f\u4e0d\u65ad\u6539\u5584\u516c\u53f8\u6cbb\u7406\u548c\u58ee\u5927\u56e2\u961f\u30022022\u5e747\u6708\uff0c\u8463\u4e8b\u4f1a\u4efb\u547dJohn Diekman\u4e3a\u9996\u5e2d\u72ec\u7acb\u8463\u4e8b\u3002\u9274\u4e8e\u9996\u5e2d\u72ec\u7acb\u8463\u4e8b\u7684\u989d\u5916\u804c\u8d23\uff0cDiekman\u5148\u751f\u4e0d\u518d\u62c5\u4efb\u5ba1\u6838\u59d4\u5458\u4f1a\u4e3b\u5e2d\u4e00\u804c\uff0c\u4f46\u4ed6\u5c06\u7ee7\u7eed\u62c5\u4efb\u5ba1\u6838\u59d4\u5458\u4f1a\u7684\u6210\u5458\uff0c\u5e76\u4e14Scott Morrison\u88ab\u4efb\u547d\u4e3a\u5ba1\u6838\u59d4\u5458\u4f1a\u4e3b\u5e2d\u3002\u6b64\u5916\uff0cJosh Smiley\u4e8e8\u67081\u65e5\u52a0\u5165\u516c\u53f8\u62c5\u4efb\u9996\u5e2d\u8fd0\u8425\u5b98\u3002\u4ed6\u5c06\u76f4\u63a5\u5411\u9996\u5e2d\u6267\u884c\u5b98\u6c47\u62a5\u5e76\u6210\u4e3a\u7ba1\u7406\u56e2\u961f\u7684\u91cd\u8981\u6210\u5458\u3002<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u518d\u9f0e\u533b\u836f\u5171\u67092,063\u540d\u5168\u804c\u5458\u5de5\uff0c\u5176\u4e2d\u4ece\u4e8b\u7814\u53d1\u548c\u5546\u4e1a\u5316\u5c97\u4f4d\u7684\u5458\u5de5\u6570\u91cf\u5206\u522b\u4e3a861\u4eba\u548c968\u4eba\u3002<\/p>\n<p><b>2022\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u8d22\u52a1\u4e1a\u7ee9<\/b><\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u603b\u6536\u5165\u4e3a4,820\u4e07\u7f8e\u5143\uff0c2021\u5e74\u540c\u671f\u6536\u5165\u4e3a3,690\u4e07\u7f8e\u5143\u3002\u5176\u4e2d\u5305\u62ec\u5219\u4e50\u4ea7\u54c1\u9500\u552e\u6536\u51653,410\u4e07\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u4e3a2,340\u4e07\u7f8e\u5143\uff09\u3001\u7231\u666e\u76fe\u4ea7\u54c1\u9500\u552e\u6536\u51651,160\u4e07\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u4e3a950\u4e07\u7f8e\u5143\uff09\u3001\u64ce\u4e50\u4ea7\u54c1\u9500\u552e\u6536\u516560\u4e07\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u4e3a400\u4e07\u7f8e\u5143\uff09\u3001\u7ebd\u518d\u4e50\u4ea7\u54c1\u9500\u552e\u6536\u5165130\u4e07\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u65e0\u6536\u5165\uff09\u3002<\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u4e8e2022\u5e746\u6708\u964d\u4f4e\u4e86\u64ce\u4e50\u548c\u7ebd\u518d\u4e50\u5bf9\u4f9b\u5e94\u5546\u7684\u552e\u4ef7\u3002\u56e0\u6b64\uff0c\u5728\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u7684\u4e09\u4e2a\u6708\u5167\uff0c\u516c\u53f8\u8ba1\u63d0\u9500\u552e\u8fd4\u5229290\u4e07\u7f8e\u5143\uff0c\u4f5c\u4e3a\u5c31\u6b64\u524d\u4ee5\u964d\u4ef7\u524d\u4ef7\u683c\u51fa\u552e\u7684\u4ea7\u54c1\u5411\u7ecf\u9500\u5546\u4f5c\u51fa\u7684\u8865\u507f\u3002<\/li>\n<\/ul>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u7814\u7a76\u4e0e\u5f00\u53d1\uff08\u7814\u53d1\uff09\u652f\u51fa\u4e3a6,610\u4e07\u7f8e\u5143\uff0c2021\u5e74\u540c\u671f\u4e3a1.422\u4ebf\u7f8e\u5143\u3002\u7814\u53d1\u652f\u51fa\u7684\u964d\u4f4e\u4e3b\u8981\u7531\u4e8e\u6ca1\u6709\u65b0\u7684\u6388\u6743\u5f15\u8fdb\u9884\u4ed8\u6b3e\uff0c\u90e8\u5206\u88ab\u6b63\u5728\u8fdb\u884c\u53ca\u65b0\u542f\u52a8\u7684\u4e34\u5e8a\u7814\u7a76\u589e\u52a0\u7684\u76f8\u5173\u8d39\u7528\u3001\u589e\u8058\u7814\u53d1\u4eba\u5458\u7684\u5de5\u8d44\u53ca\u5de5\u8d44\u76f8\u5173\u5f00\u652f\u62b5\u9500\u3002\u9664\u53bb\u65b0\u7684\u6388\u6743\u5f15\u8fdb\u7684\u9884\u4ed8\u6b3e\uff0c2021\u5e74\u540c\u671f\u6838\u5fc3\u7814\u53d1\u652f\u51fa\u4e3a5,170\u4e07\u7f8e\u5143\u3002<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u9500\u552e\u3001\u4e00\u822c\u53ca\u884c\u653f\u5f00\u652f\uff08SG&amp;A\uff09\u4e3a6,340\u4e07\u7f8e\u5143\uff0c2021\u5e74\u540c\u671f\u4e3a5,440\u4e07\u7f8e\u5143\u3002\u968f\u7740\u518d\u9f0e\u533b\u836f\u6301\u7eed\u6269\u5f20\u5e76\u6295\u8d44\u4e8e\u4e2d\u56fd\u7684\u5546\u4e1a\u5316\u8fd0\u8425\u4ee5\u671f\u672a\u6765\u51e0\u5e74\u6536\u5165\u5927\u5e45\u589e\u957f\uff0c\u8fd9\u4e00\u589e\u957f\u4e3b\u8981\u662f\u7531\u4e8e\u5546\u4e1a\u5316\u3001\u4e00\u822c\u53ca\u884c\u653f\u4eba\u5458\u589e\u52a0\u5bfc\u81f4\u7684\u5de5\u8d44\u548c\u5de5\u8d44\u76f8\u5173\u5f00\u652f\u589e\u52a0\u3002<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u518d\u9f0e\u533b\u836f\u4e8f\u635f\u51c0\u989d\u4e3a1.379\u4ebf\u7f8e\u5143\uff0c2021\u5e74\u540c\u671f\u7684\u4e8f\u635f\u51c0\u989d\u4e3a1.633\u4ebf\u7f8e\u5143\u3002\u4e8f\u635f\u51c0\u989d\u7684\u51cf\u5c11\u4e3b\u8981\u7531\u4e8e\u6ca1\u6709\u65b0\u7684\u6388\u6743\u5f15\u8fdb\u9884\u4ed8\u6b3e\uff0c\u90e8\u5206\u88ab4,220\u4e07\u7f8e\u5143\u7684\u5916\u6c47\u635f\u5931\u589e\u52a0\u6240\u62b5\u9500\u3002\u5916\u6c47\u8c03\u6574\u4e3a\u975e\u73b0\u91d1\u5e94\u8ba1\u9879\u76ee\u3002\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u4e3a0.14\u7f8e\u5143\uff0c\u800c2021\u5e74\u540c\u671f\u4e3a0.18\u7f8e\u5143\u3002\u622a\u81f32022\u5e74 6\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u6bcf\u80a1ADS\u51c0\u4e8f\u635f\u4e3a1.44\u7f8e\u5143\uff0c\u800c2021\u5e74\u540c\u671f\u4e3a1.76\u7f8e\u5143\u3002<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u3001\u77ed\u671f\u6295\u8d44\u53ca\u53d7\u9650\u5236\u73b0\u91d1\u5408\u8ba1\u4e3a12.569\u4ebf\u7f8e\u5143\uff0c\u800c\u622a\u81f32022\u5e743\u670831\u65e5\u5219\u4e3a13.13\u4ebf\u7f8e\u5143\u3002<\/p>\n<p><b>\u7535\u8bdd\u4f1a\u8bae\u548c\u7f51\u7edc\u76f4\u64ad\u76f8\u5173\u4fe1\u606f<\/b><\/p>\n<p>\u518d\u9f0e\u533b\u836f\u5c06\u4e8e\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f42022\u5e748\u670810\u65e5\u4e0a\u53488\u70b9\uff08\u5317\u4eac\u65f6\u95f48\u670810\u65e5\u665a\u4e0a8\u70b9\uff09\u4e3e\u529e\u7535\u8bdd\u4f1a\u8bae\u548c\u7f51\u7edc\u76f4\u64ad\u3002\u4e0e\u4f1a\u8005\u53ef\u4ee5\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9http:\/\/ir.zailaboratory.com\u53c2\u4e0e\u5b9e\u65f6\u7f51\u7edc\u76f4\u64ad\u3002\u5982\u679c\u53c2\u52a0\u7535\u8bdd\u4f1a\u8bae\uff0c\u9700\u63d0\u524d\u6ce8\u518c\u3002\u8be6\u7ec6\u4fe1\u606f\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u6ce8\u518c\u94fe\u63a5\uff1a<\/li>\n<\/ul>\n<p><a href=\"https:\/\/register.vevent.com\/register\/BI462e47de1af64af599432ab5c90a148b\" rel=\"nofollow\">https:\/\/register.vevent.com\/register\/BI462e47de1af64af599432ab5c90a148b<\/a><\/p>\n<p>\u6240\u6709\u53c2\u4f1a\u8005\u90fd\u5fc5\u987b\u5728\u7535\u8bdd\u4f1a\u8bae\u4e4b\u524d\u901a\u8fc7\u4e0a\u8ff0\u94fe\u63a5\u5b8c\u6210\u5728\u7ebf\u6ce8\u518c\u3002\u6ce8\u518c\u6210\u529f\u540e\uff0c<span id=\"spanHghlt8568\">\u53c2\u4f1a\u8005<\/span>\u5c06\u6536\u5230\u62e8\u5165\u53f7\u7801\u3001\u6d3b\u52a8\u5bc6\u7801\u548c\u552f\u4e00\u7684\u63a5\u5165\u6807\u8bc6\u7b26\uff0c\u7528\u4e8e\u53c2\u52a0\u7535\u8bdd\u4f1a\u8bae\u3002<\/p>\n<p>\u4f1a\u8bae\u7ed3\u675f\u540e\uff0c<span 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